{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T22:17:51Z","timestamp":1792275471799,"version":"4.4.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"4-5","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Intramural Research Program of the NIH, National Institute of Environmental Health Sciences"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Autoimmunity Reviews"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1016\/j.autrev.2014.01.022","type":"journal-article","created":{"date-parts":[[2014,1,11]],"date-time":"2014-01-11T15:46:41Z","timestamp":1389455201000},"page":"367-371","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":263,"title":["Idiopathic inflammatory myopathies and the anti-synthetase syndrome: A comprehensive review"],"prefix":"10.1016","volume":"13","author":[{"given":"Michael","family":"Mahler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick W.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marvin J.","family":"Fritzler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.autrev.2014.01.022_bb0005","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nrneurol.2011.63","article-title":"Autoimmune myopathies: autoantibodies, phenotypes and pathogenesis","volume":"7","author":"Mammen","year":"2011","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.autrev.2014.01.022_bb0010","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1186\/ar3275","article-title":"Novel autoantibodies and clinical phenotypes in adult and juvenile myositis","volume":"13","author":"Betteridge","year":"2011","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.autrev.2014.01.022_bb0015","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/MD.0b013e31829d08f9","article-title":"The myositis autoantibody phenotypes of the juvenile idiopathic inflammatory myopathies","volume":"92","author":"Rider","year":"2013","journal-title":"Med (Baltimore)"},{"key":"10.1016\/j.autrev.2014.01.022_bb0020","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s11926-013-0335-1","article-title":"Autoantibodies in polymyositis and dermatomyositis","volume":"15","author":"Ghirardello","year":"2013","journal-title":"Curr Rheumatol Rep"},{"key":"10.1016\/j.autrev.2014.01.022_bb0025","doi-asserted-by":"crossref","first-page":"R78","DOI":"10.1186\/ar2276","article-title":"Heterogeneity of autoantibodies in 100 patients with autoimmune myositis: insights into clinical features and outcomes","volume":"9","author":"Koenig","year":"2007","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.autrev.2014.01.022_bb0030","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1749-6632.2009.05127.x","article-title":"Epitope specificity and significance in systemic autoimmune diseases","volume":"1183","author":"Mahler","year":"2010","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.autrev.2014.01.022_bb0035","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.autrev.2009.02.012","article-title":"Commercial blot assays in the diagnosis of systemic rheumatic diseases","volume":"8","author":"Ghirardello","year":"2009","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.autrev.2014.01.022_bb0040","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1136\/annrheumdis-2012-201800","article-title":"Patients with non-Jo-1 anti-tRNA-synthetase autoantibodies have worse survival than Jo-1 positive patients","volume":"73","author":"Aggarwal","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2014.01.022_bb0045","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.rmed.2012.09.005","article-title":"Pulmonary manifestations of anti-ARS antibody positive interstitial pneumonia\u2014with or without PM\/DM","volume":"107","author":"Takato","year":"2013","journal-title":"Respir Med"},{"key":"10.1016\/j.autrev.2014.01.022_bb0050","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1097\/MD.0b013e318260977c","article-title":"Anti-PL-7 (Anti-threonyl-tRNA synthetase) antisynthetase syndrome: clinical manifestations in a series of patients from a European multicenter study (EUMYONET) and review of the literature","volume":"91","author":"Labirua-Iturburu","year":"2012","journal-title":"Med (Baltimore)"},{"key":"10.1016\/j.autrev.2014.01.022_bb0055","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1002\/mus.23383","article-title":"Isolated necrotizing myopathy associated with ANTI-PL12 antibody","volume":"46","author":"Mehndiratta","year":"2012","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.autrev.2014.01.022_bb0060","article-title":"Autoantibodies to MUC1 glycopeptides cannot be used as a screening assay for early detection of breast, ovarian, lung or pancreatic cancer","volume":"10","author":"Burford","year":"2013","journal-title":"Br J Cancer"},{"key":"10.1016\/j.autrev.2014.01.022_bb0065","doi-asserted-by":"crossref","first-page":"909","DOI":"10.6061\/clinics\/2013(07)04","article-title":"Myositis-specific and myositis-associated autoantibody profiles and their clinical associations in a large series of patients with polymyositis and dermatomyositis","volume":"68","author":"Cruellas","year":"2013","journal-title":"Clinics (Sao Paulo)"},{"key":"10.1016\/j.autrev.2014.01.022_bb0070","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1378\/chest.08-2233","article-title":"Clinical profile of anti-PL-12 autoantibody. Cohort study and review of the literature","volume":"135","author":"Kalluri","year":"2009","journal-title":"Chest"},{"key":"10.1016\/j.autrev.2014.01.022_bb0075","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.autrev.2012.01.006","article-title":"Comparison of long-term outcome between anti-Jo1- and anti-PL7\/PL12 positive patients with antisynthetase syndrome","volume":"11","author":"Marie","year":"2012","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.autrev.2014.01.022_bb0080","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.autrev.2012.06.006","article-title":"Hierarchical cluster and survival analyses of antisynthetase syndrome: phenotype and outcome are correlated with anti-tRNA synthetase antibody specificity","volume":"12","author":"Hervier","year":"2012","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.autrev.2014.01.022_bb0085","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1056\/NEJMcpc1208147","article-title":"Case records of the Massachusetts General Hospital. Case 37-2012. A 21-year-old man with fevers, arthralgias, and pulmonary infiltrates","volume":"367","author":"Christopher-Stine","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1016\/j.autrev.2014.01.022_bb0090","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.2169\/internalmedicine.51.7452","article-title":"The clinical characteristics of two anti-OJ (anti-isoleucyl-tRNA synthetase) autoantibody-positive interstitial lung disease patients with polymyositis\/dermatomyositis","volume":"51","author":"Kunimasa","year":"2012","journal-title":"Intern Med"},{"key":"10.1016\/j.autrev.2014.01.022_bb0095","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.autrev.2008.06.007","article-title":"Challenges to the use of autoantibodies as predictors of disease onset, diagnosis and outcomes","volume":"7","author":"Fritzler","year":"2008","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.autrev.2014.01.022_bb0100","doi-asserted-by":"crossref","first-page":"9933","DOI":"10.1073\/pnas.87.24.9933","article-title":"The role of an autoantigen, histidyl-tRNA synthetase, in the induction and maintenance of autoimmunity","volume":"87","author":"Miller","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.autrev.2014.01.022_bb0105","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.autrev.2012.05.011","article-title":"Autoantibodies in systemic sclerosis","volume":"12","author":"Mehra","year":"2013","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.autrev.2014.01.022_bb0110","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/S0002-9343(70)80006-7","article-title":"The epidemiology of polymyositis","volume":"48","author":"Medsger","year":"1970","journal-title":"Am J Med"},{"key":"10.1016\/j.autrev.2014.01.022_bb0115","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/S0140-6736(03)14368-1","article-title":"Polymyositis and dermatomyositis","volume":"362","author":"Dalakas","year":"2003","journal-title":"Lancet"},{"issue":"14","key":"10.1016\/j.autrev.2014.01.022_bb0120","first-page":"337","article-title":"Naarden, The Netherlands","volume":"2004","author":"Hoogendijk","year":"2003","journal-title":"Neuromuscul Disord"},{"key":"10.1016\/j.autrev.2014.01.022_bb0125","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s11926-013-0349-8","article-title":"Clinical heterogeneity and outcomes of antisynthetase syndrome","volume":"15","author":"Hervier","year":"2013","journal-title":"Curr Rheumatol Rep"},{"key":"10.1016\/j.autrev.2014.01.022_bb0130","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1056\/NEJM197502202920807","article-title":"Polymyositis and dermatomyositis (second of two parts)","volume":"292","author":"Bohan","year":"1975","journal-title":"N Engl J Med"},{"key":"10.1016\/j.autrev.2014.01.022_bb0135","first-page":"767","article-title":"Classifying idiopathic inflammatory myopathies: comparing the performance of six existing criteria","volume":"31","author":"Linklater","year":"2013","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.autrev.2014.01.022_bb0140","doi-asserted-by":"crossref","first-page":"2556","DOI":"10.1172\/JCI116493","article-title":"Reaction of anti-OJ autoantibodies with components of the multi-enzyme complex of aminoacyl-tRNA synthetases in addition to isoleucyl-tRNA synthetase","volume":"91","author":"Targoff","year":"1993","journal-title":"J Clin Invest"},{"key":"10.1016\/j.autrev.2014.01.022_bb0145","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.autrev.2009.02.010","article-title":"Latest update on the Ro\/SS-A autoantibody system","volume":"8","author":"Schulte-Pelkum","year":"2009","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.autrev.2014.01.022_bb0150","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.semarthrit.2011.09.008","article-title":"Short-term and long-term outcome of anti-Jo1-positive patients with anti-Ro52 antibody","volume":"41","author":"Marie","year":"2012","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.autrev.2014.01.022_bb0155","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1093\/clinchem\/48.12.2171","article-title":"Detection of specific antinuclear reactivities in patients with negative anti-nuclear antibody immunofluorescence screening tests","volume":"48","author":"Hoffman","year":"2002","journal-title":"Clin Chem"},{"key":"10.1016\/j.autrev.2014.01.022_bb0160","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.2174\/092986706778201639","article-title":"The emergence of multiplexed technologies as diagnostic platforms in systemic autoimmune diseases","volume":"13","author":"Fritzler","year":"2006","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.autrev.2014.01.022_bb0165","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.cca.2013.05.011","article-title":"Clinical performance evaluation of a novel rapid response chemiluminescent immunoassay for the detection of autoantibodies to extractable nuclear antigens","volume":"424","author":"Bentow","year":"2014","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.autrev.2014.01.022_bb0170","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.autrev.2009.03.005","article-title":"Use of a commercial line blot assay as a screening test for autoantibodies in inflammatory myopathies","volume":"9","author":"Ronnelid","year":"2009","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.autrev.2014.01.022_bb0175","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1093\/rheumatology\/keq281","article-title":"Diagnostic performance and validation of autoantibody testing in myositis by a commercial line blot assay","volume":"49","author":"Ghirardello","year":"2010","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.autrev.2014.01.022_bb0180","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1136\/ard.2008.093161","article-title":"Estimating the prevalence of polymyositis and dermatomyositis from administrative data: age, sex and regional differences","volume":"68","author":"Bernatsky","year":"2009","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2014.01.022_bb0185","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1093\/brain\/98.4.637","article-title":"Polymyositis: its presentation, morbidity and mortality","volume":"98","author":"DeVere","year":"1975","journal-title":"Brain"},{"key":"10.1016\/j.autrev.2014.01.022_bb0190","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1056\/NEJM199111213252107","article-title":"Polymyositis, dermatomyositis, and inclusion-body myositis","volume":"325","author":"Dalakas","year":"1991","journal-title":"N Engl J Med"},{"key":"10.1016\/j.autrev.2014.01.022_bb0195","first-page":"668","article-title":"Classification criteria for polymyositis and dermatomyositis","volume":"22","author":"Tanimoto","year":"1995","journal-title":"J Rheumatol"},{"key":"10.1016\/j.autrev.2014.01.022_bb0200","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1097\/00002281-199711000-00008","article-title":"Classification criteria for the idiopathic inflammatory myopathies","volume":"9","author":"Targoff","year":"1997","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.autrev.2014.01.022_bb0205","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1212\/WNL.61.3.316","article-title":"Polymyositis: an overdiagnosed entity","volume":"61","author":"Van Der Meulen","year":"2003","journal-title":"Neurology"}],"container-title":["Autoimmunity Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568997214000342?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568997214000342?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T02:49:54Z","timestamp":1597373394000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568997214000342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":41,"journal-issue":{"issue":"4-5","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["S1568997214000342"],"URL":"https:\/\/doi.org\/10.1016\/j.autrev.2014.01.022","relation":{},"ISSN":["1568-9972"],"issn-type":[{"value":"1568-9972","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Idiopathic inflammatory myopathies and the anti-synthetase syndrome: A comprehensive review","name":"articletitle","label":"Article Title"},{"value":"Autoimmunity Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.autrev.2014.01.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}