{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T12:54:35Z","timestamp":1787057675244,"version":"build-2736575974"},"reference-count":149,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Autoimmunity Reviews"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.autrev.2015.08.004","type":"journal-article","created":{"date-parts":[[2015,8,12]],"date-time":"2015-08-12T04:46:23Z","timestamp":1439354783000},"page":"1161-1169","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":108,"title":["New insights into immune mechanisms underlying autoimmune diseases of the gastrointestinal tract"],"prefix":"10.1016","volume":"14","author":[{"given":"Antonio","family":"Di Sabatino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Vincenzo","family":"Lenti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Giuffrida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Vanoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gino Roberto","family":"Corazza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.autrev.2015.08.004_bb0005","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nrg2489","article-title":"Detecting shared pathogenesis from the shared genetics of immune-related diseases","volume":"10","author":"Zhernakova","year":"2009","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.autrev.2015.08.004_bb0010","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.autrev.2014.05.006","article-title":"Hot topics in autoimmune diseases: perspectives from the 2013 Asian Congress of Autoimmunity","volume":"13","author":"Selmi","year":"2014","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.autrev.2015.08.004_bb0015","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1136\/ard.60.5.433","article-title":"Cancer and autoimmunity: autoimmune and rheumatic features in patients with malignancies","volume":"60","author":"Abu-Shakra","year":"2001","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2015.08.004_bb0020","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1615\/CritRevImmunol.v28.i5.10","article-title":"New concepts on the pathogenesis of autoimmune diseases: a role for immune homeostasis, immunoregulation, and immunosenescence","volume":"28","author":"Thewissen","year":"2008","journal-title":"Crit Rev Immunol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0025","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.coi.2004.09.005","article-title":"Emerging approaches for the therapy of autoimmune and chronic inflammatory disease","volume":"16","author":"Cope","year":"2004","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0030","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.coi.2006.09.004","article-title":"Immune therapies of autoimmune diseases: are we approaching a real cure?","volume":"18","author":"Chatenoud","year":"2006","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0035","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1126\/science.1106442","article-title":"Immunity, inflammation, and allergy in the gut","volume":"307","author":"MacDonald","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.autrev.2015.08.004_bb0040","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S0140-6736(97)01042-8","article-title":"Autoimmune enteropathy and villous atrophy in adults","volume":"350","author":"Corazza","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.autrev.2015.08.004_bb0045","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1001\/archinte.1996.00040041097008","article-title":"Prevalence of undiagnosed pernicious anemia in the elderly","volume":"156","author":"Carmel","year":"1996","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.autrev.2015.08.004_bb0050","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.cgh.2012.02.018","article-title":"Common features of patients with autoimmune atrophic gastritis","volume":"10","author":"Miceli","year":"2012","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0055","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/S0140-6736(09)60254-3","article-title":"Coeliac disease","volume":"373","author":"Di Sabatino","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.autrev.2015.08.004_bb0060","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1111\/j.1365-2036.2012.05101.x","article-title":"Autoimmune gastritis: histology phenotype and OLGA staging","volume":"35","author":"Rugge","year":"2012","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.autrev.2015.08.004_bb0065","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nrgastro.2013.101","article-title":"Autoimmune atrophic gastritis \u2014 pathogenesis, pathology and management","volume":"10","author":"Neumann","year":"2013","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0070","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1016\/j.humpath.2013.02.005","article-title":"Histologic changes in type A chronic atrophic gastritis indicating increased risk of neuroendocrine tumor development: the predictive role of dysplastic and severely hyperplastic enterochromaffin-like cell lesions","volume":"44","author":"Vanoli","year":"2013","journal-title":"Hum Pathol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0075","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1172\/JCI113344","article-title":"Major parietal cell antigen in autoimmune gastritis with pernicious anemia is the acid-producing H+, K+-adenosine triphosphatase of the stomach","volume":"81","author":"Karlsson","year":"1988","journal-title":"J Clin Invest"},{"key":"10.1016\/j.autrev.2015.08.004_bb0080","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1046\/j.1365-2567.1997.00302.x","article-title":"Immunization with gastric H+\/K(+)-ATPase induces a reversible autoimmune gastritis","volume":"92","author":"Scarff","year":"1997","journal-title":"Immunology"},{"key":"10.1016\/j.autrev.2015.08.004_bb0085","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1006\/clim.2001.5134","article-title":"Animal models of human disease: experimental autoimmune gastritis \u2014 a model for autoimmune gastritis and pernicious anemia","volume":"102","author":"Alderuccio","year":"2002","journal-title":"Clin Immunol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0090","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1002\/(SICI)1521-4141(199902)29:02<669::AID-IMMU669>3.0.CO;2-J","article-title":"Post-thymectomy autoimmune gastritis: fine specificity and pathogenicity of anti-H\/K ATPase-reactive T cells","volume":"29","author":"Suri-Payer","year":"1999","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0095","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.4049\/jimmunol.157.4.1799","article-title":"Pathogenesis of post-thymectomy autoimmune gastritis. Identification of anti-H\/K adenosine triphosphatase-reactive T cells","volume":"157","author":"Suri-Payer","year":"1996","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0100","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1053\/gast.1996.v110.pm8964405","article-title":"Analysis of mononuclear cell infiltrate and cytokine production in murine autoimmune gastritis","volume":"110","author":"Martinelli","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.autrev.2015.08.004_bb0105","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1111\/jgh.12144","article-title":"Interleukin-21 and tumor necrosis factor-\u03b1 are critical for the development of autoimmune gastritis in mice","volume":"28","author":"Nishiura","year":"2013","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0110","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.jaci.2015.04.011","article-title":"Dichotomy of short and long thymic stromal lymphopoietin isoforms in inflammatory disorders of the bowel and skin","volume":"136","author":"Fornasa","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0115","doi-asserted-by":"crossref","first-page":"190","DOI":"10.4049\/jimmunol.1003787","article-title":"Increased susceptibility to autoimmune gastritis in thymic stromal lymphopoietin receptor-deficient mice","volume":"188","author":"Nishiura","year":"2012","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0120","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1002\/eji.201142341","article-title":"Both IFN-\u03b3 and IL-17 are required for the development of severe autoimmune gastritis","volume":"42","author":"Tu","year":"2012","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0125","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1053\/gast.2001.21187","article-title":"H(+), K(+)-atpase (proton pump) is the target autoantigen of Th1-type cytotoxic T cells in autoimmune gastritis","volume":"120","author":"D'Elios","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.autrev.2015.08.004_bb0130","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1136\/gut.31.6.647","article-title":"Relation between T cell number and epithelial HLA class II expression quantified by image analysis in normal and inflamed human gastric mucosa","volume":"31","author":"Valnes","year":"1990","journal-title":"Gut"},{"key":"10.1016\/j.autrev.2015.08.004_bb0135","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/S0198-8859(01)00281-6","article-title":"Expression of cathepsins B, L, S, and D by gastric epithelial cells implicates them as antigen presenting cells in local immune responses","volume":"62","author":"Barrera","year":"2001","journal-title":"Hum Immunol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0140","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1053\/gast.2002.35383","article-title":"Fas\/CD95 is required for gastric mucosal damage in autoimmune gastritis","volume":"123","author":"Marshall","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.autrev.2015.08.004_bb0145","first-page":"G209","article-title":"Autoimmune gastritis results in disruption of gastric epithelial cell development","volume":"277","author":"Judd","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0150","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1136\/jcp.2010.081232","article-title":"Significant increase in IgG4+ plasma cells in gastric biopsy specimens from patients with pernicious anaemia","volume":"63","author":"Bedeir","year":"2010","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0155","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/(SICI)1097-0029(20000315)48:6<321::AID-JEMT2>3.0.CO;2-U","article-title":"Role of antigastric autoantibodies in chronic Helicobacter pylori infection","volume":"48","author":"Faller","year":"2000","journal-title":"Microsc Res Tech"},{"key":"10.1016\/j.autrev.2015.08.004_bb0160","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1053\/gast.1996.v111.pm8780570","article-title":"Antigenic mimicry between Helicobacter pylori and gastric mucosa in the pathogenesis of body atrophic gastritis","volume":"111","author":"Negrini","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.autrev.2015.08.004_bb0165","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.molmed.2004.06.001","article-title":"Gastric autoimmunity: the role of Helicobacter pylori and molecular mimicry","volume":"10","author":"D'Elios","year":"2004","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.autrev.2015.08.004_bb0170","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/bjc.1989.169","article-title":"Cancer risk following pernicious anaemia","volume":"59","author":"Brinton","year":"1989","journal-title":"Br J Cancer"},{"key":"10.1016\/j.autrev.2015.08.004_bb0175","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1002\/1097-0142(19930201)71:3<745::AID-CNCR2820710316>3.0.CO;2-1","article-title":"Pernicious anemia and subsequent cancer. A population-based cohort study","volume":"71","author":"Hsing","year":"1993","journal-title":"Cancer"},{"key":"10.1016\/j.autrev.2015.08.004_bb0180","first-page":"793","article-title":"Distinct patterns of chronic gastritis associated with carcinoid and cancer and their role in tumorigenesis","volume":"65","author":"Solcia","year":"1992","journal-title":"Yale J Biol Med"},{"key":"10.1016\/j.autrev.2015.08.004_bb0185","doi-asserted-by":"crossref","first-page":"856","DOI":"10.3109\/00365521.2015.1010570","article-title":"Occurrence of gastric cancer and carcinoids in atrophic gastritis during prospective long-term follow up","volume":"50","author":"Lahner","year":"2015","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.cgh.2015.05.040","article-title":"Cancer risk after pernicious anemia in the US elderly population","author":"Murphy","year":"2015","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0195","doi-asserted-by":"crossref","first-page":"S232","DOI":"10.1093\/carcin\/bgv038","article-title":"Environmental immune disruptors, inflammation and cancer risk","volume":"36","author":"Thompson","year":"2015","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.autrev.2015.08.004_bb0200","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.ejca.2008.09.019","article-title":"Association between a pro-inflammatory genetic profile and the risk of chronic atrophic gastritis among older adults from Germany","volume":"45","author":"Gao","year":"2009","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.autrev.2015.08.004_bb0205","doi-asserted-by":"crossref","first-page":"5235","DOI":"10.3748\/wjg.v20.i18.5235","article-title":"Cytokines, cytokine gene polymorphisms and Helicobacter pylori infection: friend or foe?","volume":"20","author":"Figueiredo","year":"2014","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0210","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1158\/0008-5472.CAN-12-3957","article-title":"Autoimmune gastritis mediated by CD4+ T cells promotes the development of gastric cancer","volume":"73","author":"Nguyen","year":"2013","journal-title":"Cancer Res"},{"key":"10.1016\/j.autrev.2015.08.004_bb0215","doi-asserted-by":"crossref","first-page":"130","DOI":"10.3109\/00365529109093190","article-title":"Trophic effects of gastrin","volume":"180","author":"Hakanson","year":"1991","journal-title":"Scand J Gastroenterol Suppl"},{"key":"10.1016\/j.autrev.2015.08.004_bb0220","first-page":"L311","article-title":"Tumor necrosis factor induces neuroendocrine differentiation in small cell lung cancer cell lines","volume":"275","author":"Haley","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0225","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s00251-012-0599-z","article-title":"Nomenclature and listing of celiac disease relevant gluten T-cell epitopes restricted by HLA-DQ molecules","volume":"64","author":"Sollid","year":"2012","journal-title":"Immunogenetics"},{"key":"10.1016\/j.autrev.2015.08.004_bb0230","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/ng.543","article-title":"Multiple common variants for celiac disease influencing immune gene expression","volume":"42","author":"Dubois","year":"2010","journal-title":"Nat Genet"},{"key":"10.1016\/j.autrev.2015.08.004_bb0235","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/ng2058","article-title":"A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21","volume":"39","author":"van Heel","year":"2007","journal-title":"Nat Genet"},{"key":"10.1016\/j.autrev.2015.08.004_bb0240","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1136\/gutjnl-2011-300327","article-title":"Intestinal permeability in coeliac disease: insight into mechanisms and relevance to pathogenesis","volume":"61","author":"Heyman","year":"2012","journal-title":"Gut"},{"key":"10.1016\/j.autrev.2015.08.004_bb0245","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1152\/physrev.00003.2008","article-title":"Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity and cancer","volume":"91","author":"Fasano","year":"2011","journal-title":"Physiol Rev"},{"key":"10.1016\/j.autrev.2015.08.004_bb0250","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1084\/jem.20071204","article-title":"Secretory IgA mediates retrotranscytosis of intact gliadin peptides via the transferrin receptor in celiac disease","volume":"205","author":"Matysiak-Budnik","year":"2008","journal-title":"J Exp Med"},{"key":"10.1016\/j.autrev.2015.08.004_bb0255","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.autrev.2012.01.007","article-title":"The function of tissue transglutaminase in celiac disease","volume":"11","author":"Di Sabatino","year":"2012","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.autrev.2015.08.004_bb0260","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1053\/j.gastro.2012.05.051","article-title":"Interactions among secretory immunoglobulin A, CD71, and Transglutaminase-2 affect permeability of intestinal epithelial cells to gliadin peptides","volume":"143","author":"Lebreton","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.autrev.2015.08.004_bb0265","article-title":"Abnormal thymic stromal lymphopoietin expression in the duodenal mucosa of patients with coeliac disease","author":"Biancheri","year":"2015","journal-title":"Gut"},{"key":"10.1016\/j.autrev.2015.08.004_bb0270","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1136\/gut.2003.030551","article-title":"Regulation of the T helper cell type 1 transcription factor T-bet in coeliac disease mucosa","volume":"53","author":"Monteleone","year":"2004","journal-title":"Gut"},{"key":"10.1016\/j.autrev.2015.08.004_bb0275","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.4049\/jimmunol.0901919","article-title":"Characterization of IL-17A-producing cells in celiac disease mucosa","volume":"184","author":"Monteleone","year":"2010","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0280","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1136\/gut.2007.129882","article-title":"Interleukin 21 contributes to the mucosal T helper cell type 1 response in coeliac disease","volume":"57","author":"Fina","year":"2008","journal-title":"Gut"},{"key":"10.1016\/j.autrev.2015.08.004_bb0285","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/nm.2656","article-title":"High abundance of plasma cells secreting transglutaminase 2-specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions","volume":"18","author":"Di Niro","year":"2012","journal-title":"Nat Med"},{"key":"10.1016\/j.autrev.2015.08.004_bb0290","doi-asserted-by":"crossref","first-page":"17146","DOI":"10.1073\/pnas.1407457111","article-title":"Activity-regulating structural changes and autoantibody epitopes in transglutaminase 2 assessed by hydrogen\/deuterium exchange","volume":"111","author":"Iversen","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.autrev.2015.08.004_bb0295","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.cytogfr.2010.09.003","article-title":"Role of IL-15 in immune-mediated and infectious diseases","volume":"22","author":"Di Sabatino","year":"2011","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.autrev.2015.08.004_bb0300","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1136\/gut.2005.068684","article-title":"Epithelium derived interleukin 15 regulates intraepithelial lymphocyte Th1 cytokine production, cytotoxicity, and survival in coeliac disease","volume":"55","author":"Di Sabatino","year":"2006","journal-title":"Gut"},{"key":"10.1016\/j.autrev.2015.08.004_bb0305","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/S0016-5085(00)70173-9","article-title":"Selective expansion of intraepithelial lymphocytes expressing the HLA-E-specific natural killer receptor CD94 in celiac disease","volume":"118","author":"Jabri","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1016\/j.autrev.2015.08.004_bb0310","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/mi.2012.65","article-title":"IL-15 positively regulates IL-21 production in celiac disease mucosa","volume":"6","author":"Sarra","year":"2013","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0315","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/ajg.2011.397","article-title":"Impaired control of effector T cells by regulatory T cells: a clue to loss of oral tolerance and autoimmunity in celiac disease?","volume":"107","author":"Belhadi Hmida","year":"2012","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0320","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1053\/j.gastro.2006.12.025","article-title":"Inhibition of TGF-beta signaling by IL-15: a new role for IL-15 in the loss of immune homeostasis in celiac disease","volume":"132","author":"Benahmed","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.autrev.2015.08.004_bb0325","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.cytogfr.2013.11.001","article-title":"The role of transforming growth factor (TGF)-\u03b2 in modulating the immune response and fibrogenesis in the gut","volume":"25","author":"Biancheri","year":"2014","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.autrev.2015.08.004_bb0345","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.1182\/blood-2011-10-385559","article-title":"How I treat enteropathy-associated T-cell lymphoma","volume":"119","author":"Di Sabatino","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.autrev.2015.08.004_bb0350","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1042\/CS20130478","article-title":"Analysis of cytokine profile in the duodenal mucosa of refractory coeliac disease patients","volume":"126","author":"Caruso","year":"2014","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.autrev.2015.08.004_bb0355","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1586\/17474124.2015.1033399","article-title":"Celiac disease 2015 update: new therapies","volume":"9","author":"Veeraraghavan","year":"2015","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0360","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1053\/j.gastro.2015.02.008","article-title":"Larazotide acetate for persistent symptoms of celiac disease despite a gluten-free diet: a randomized controlled trial","volume":"148","author":"Leffler","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.autrev.2015.08.004_bb0365","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1053\/j.gastro.2014.02.031","article-title":"Glutenase ALV003 attenuates gluten-induced mucosal injury in patients with celiac disease","volume":"146","author":"L\u00e4hdeaho","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.autrev.2015.08.004_bb0370","doi-asserted-by":"crossref","first-page":"5837","DOI":"10.3748\/wjg.v19.i35.5837","article-title":"Consumption of gluten with gluten-degrading enzyme by celiac patients: a pilot-study","volume":"19","author":"Tack","year":"2013","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0375","series-title":"J Pediatric Gastroenterology Nutrition Hepatology and Nutrition Annual Meeting; Istambul, Turkey","first-page":"E68","article-title":"Food-grade degrading enzymes to treat dietary transgressions in coeliac adolescents","author":"Korponay-Szabo","year":"2010"},{"key":"10.1016\/j.autrev.2015.08.004_bb0380","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/j.1365-2249.2008.03635.x","article-title":"Live probiotic Bifidobacterium lactis bacteria inhibit the toxic effects induced by wheat gliadin in epithelial cell culture","volume":"152","author":"Lindfors","year":"2008","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0385","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1189\/jlb.0709471","article-title":"Pivotal advance: Bifidobacteria and Gram-negative bacteria differentially influence immune responses in the proinflammatory milieu of celiac disease","volume":"87","author":"De Palma","year":"2010","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0390","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1053\/j.gastro.2008.09.016","article-title":"Polymeric binders suppress gliadin-induced toxicity in the intestinal epithelium","volume":"136","author":"Pinier","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.autrev.2015.08.004_bb0395","doi-asserted-by":"crossref","first-page":"S437","DOI":"10.1016\/S0016-5085(11)61794-0","article-title":"A phase I study to determine safety, tolerability and bioactivity of Nexvax2\u00ae in HLA DQ2+ volunteers with celiac disease following a long-term, strict gluten-free diet","volume":"140","author":"Brown","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.autrev.2015.08.004_bb0405","doi-asserted-by":"crossref","first-page":"6253","DOI":"10.1016\/j.bmc.2007.06.020","article-title":"Structure-based design of alpha-amido aldehyde containing gluten peptide analogues as modulators of HLA-DQ2 and transglutaminase 2","volume":"15","author":"Siegel","year":"2007","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.autrev.2015.08.004_bb0415","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1172\/JCI41344","article-title":"IL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease-associated inflammation and lymphomagenesis","volume":"120","author":"Malamut","year":"2010","journal-title":"J Clin Invest"},{"key":"10.1016\/j.autrev.2015.08.004_bb0425","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1097\/00005176-198506000-00009","article-title":"Autoimmunity in diarrhoeal disease","volume":"4","author":"Unsworth","year":"1985","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.autrev.2015.08.004_bb0430","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/j.cgh.2007.05.013","article-title":"Adult autoimmune enteropathy: Mayo Clinic Rochester experience","volume":"5","author":"Akram","year":"2007","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0435","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1097\/PAS.0000000000000317","article-title":"Gastrointestinal biopsy findings of autoimmune enteropathy: a review of 25 cases","volume":"38","author":"Masia","year":"2014","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0440","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1111\/j.1572-0241.2004.40039.x","article-title":"Clinical and immunological features of adult-onset generalized autoimmune gut disorder","volume":"99","author":"Le\u00f3n","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0445","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1080\/00365520902783691","article-title":"Autoimmune enteropathy in children and adults","volume":"44","author":"Montalto","year":"2009","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0450","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/S0140-6736(82)92076-1","article-title":"Autoantibodies against gut epithelium in a child with small intestinal enteropathy","volume":"1","author":"Walker-Smith","year":"1982","journal-title":"Lancet"},{"key":"10.1016\/j.autrev.2015.08.004_bb0455","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0896-8411(88)90032-7","article-title":"HLA product expression and lymphocyte subpopulation in jejunum biopsies of children with idiopathic protracted diarrhoea and enterocyte autoantibodies","volume":"1","author":"Mirakian","year":"1988","journal-title":"J Autoimmun"},{"key":"10.1016\/j.autrev.2015.08.004_bb0460","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3109\/08916939209004829","article-title":"LFA-1 and ICAM-1 molecule expression in jejunal mucosa from children with autoimmune enteropathy","volume":"13","author":"Hill","year":"1992","journal-title":"Autoimmunity"},{"key":"10.1016\/j.autrev.2015.08.004_bb0465","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/0046-8177(95)90283-X","article-title":"Autoimmune enteropathy with anti-goblet cell antibodies","volume":"26","author":"Moore","year":"1995","journal-title":"Hum Pathol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0470","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s004280050277","article-title":"Autoimmune enteropathy in infants: pathological study of the disease in two familial cases","volume":"433","author":"Lachaux","year":"1998","journal-title":"Virchows Arch"},{"key":"10.1016\/j.autrev.2015.08.004_bb0475","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1046\/j.1365-2249.2002.01795.x","article-title":"Mechanisms of villous atrophy in autoimmune enteropathy and coeliac disease","volume":"128","author":"Ciccocioppo","year":"2002","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0480","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1097\/MCG.0b013e31829e460e","article-title":"Autoimmune enteropathy in a 13-year-old celiac girl successfully treated with infliximab","volume":"48","author":"Valitutti","year":"2014","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0485","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1007\/s10620-005-2666-x","article-title":"Adult-onset autoimmune enteropathy in the setting of thymoma successfully treated with infliximab","volume":"50","author":"Elwing","year":"2005","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.autrev.2015.08.004_bb0490","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1159\/000084648","article-title":"Management of severe refractory adult autoimmune enteropathy with infliximab and tacrolimus","volume":"71","author":"von Hahn","year":"2005","journal-title":"Digestion"},{"key":"10.1016\/j.autrev.2015.08.004_bb0495","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.aller.2009.04.002","article-title":"From autoimmune enteropathy to the IPEX (immune dysfunction, polyendocrinopathy, enteropathy, X-linked) syndrome","volume":"37","author":"Quiros","year":"2009","journal-title":"Allergol Immunopathol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0500","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1749-6632.2011.06308.x","article-title":"Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy: known novel aspects of the syndrome","volume":"1246","author":"Kisand","year":"2011","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.autrev.2015.08.004_bb0505","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1007\/s11894-012-0276-2","article-title":"Autoimmune enteropathy: a review and update of clinical management","volume":"14","author":"Gentile","year":"2012","journal-title":"Curr Gastroenterol Rep"},{"key":"10.1016\/j.autrev.2015.08.004_bb0510","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1136\/gut.32.11.1421","article-title":"Response to autoimmune enteropathy to cyclosporin A therapy","volume":"32","author":"Sanderson","year":"1991","journal-title":"Gut"},{"key":"10.1016\/j.autrev.2015.08.004_bb0515","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1053\/gast.1996.v111.pm8698205","article-title":"Treatment of pediatric autoimmune enteropathy with tacrolimus (FK506)","volume":"111","author":"Bousvaros","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.autrev.2015.08.004_bb0520","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1053\/j.gastro.2011.12.040","article-title":"Enteropathy-associated T-cell lymphoma complicating an autoimmune enteropathy","volume":"142","author":"Malamut","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.autrev.2015.08.004_bb0525","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s11739-011-0719-z","article-title":"Recent advances in understanding ulcerative colitis","volume":"7","author":"Di Sabatino","year":"2012","journal-title":"Intern Emerg Med"},{"key":"10.1016\/j.autrev.2015.08.004_bb0530","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.autrev.2013.06.004","article-title":"Innate and adaptive immunity in inflammatory bowel disease","volume":"13","author":"Geremia","year":"2014","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.autrev.2015.08.004_bb0535","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s00441-012-1390-z","article-title":"Proteases and the gut barrier","volume":"351","author":"Biancheri","year":"2013","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.autrev.2015.08.004_bb0540","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/S0016-5085(97)70091-X","article-title":"CD95 (APO-1\/Fas)-mediated apoptosis in colon epithelial cells: a possible role in ulcerative colitis","volume":"113","author":"Str\u00e4ter","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1016\/j.autrev.2015.08.004_bb0545","first-page":"111","article-title":"Expression of IL-8, TNF-alpha and IFN-gamma m-RNA in ulcerative colitis, particularly in patients with inactive phase","volume":"46","author":"Masuda","year":"1995","journal-title":"J Clin Lab Immunol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0550","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1002\/eji.201142327","article-title":"IL-6 promotes immune responses in human ulcerative colitis and induces a skin-homing phenotype in the dendritic cells and T cells they stimulate","volume":"42","author":"Bernardo","year":"2012","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0555","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1136\/gut.2009.182170","article-title":"Differential regulation of interleukin 17 and interferon gamma production in inflammatory bowel disease","volume":"58","author":"Rovedatti","year":"2009","journal-title":"Gut"},{"key":"10.1016\/j.autrev.2015.08.004_bb0560","doi-asserted-by":"crossref","first-page":"8017","DOI":"10.1073\/pnas.0912678107","article-title":"Epithelial-derived IL-33 and its receptor ST2 are dysregulated in ulcerative colitis and in experimental Th1\/Th2 driven enteritis","volume":"107","author":"Pastorelli","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.autrev.2015.08.004_bb0565","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/cei.12061","article-title":"Epithelial expression of interleukin-37b in inflammatory bowel disease","volume":"172","author":"Imaeda","year":"2013","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0570","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10787-011-0104-6","article-title":"Targeting leucocyte migration and adhesion in Crohn's disease and ulcerative colitis","volume":"20","author":"Thomas","year":"2012","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.autrev.2015.08.004_bb0575","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.coph.2004.06.005","article-title":"Matrix metalloproteinases and the gut \u2014 new roles for old enzymes","volume":"4","author":"Pender","year":"2004","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0580","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1053\/j.gastro.2007.04.069","article-title":"Functional modulation of Crohn's disease myofibroblasts by anti-tumor necrosis factor antibodies","volume":"133","author":"Di Sabatino","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.autrev.2015.08.004_bb0585","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/ibd.20302","article-title":"Matrix metalloproteinase-3 production by gut IgG plasma cells in chronic inflammatory bowel disease","volume":"14","author":"Gordon","year":"2008","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.autrev.2015.08.004_bb0590","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1046\/j.1365-2249.2000.01227.x","article-title":"Increased production of matrix metalloproteinase-3 and tissue inhibitor of metalloproteinase-1 by inflamed mucosa in inflammatory bowel disease","volume":"120","author":"Louis","year":"2000","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0595","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2015.07.002","article-title":"Proteolytic cleavage and loss of function of biologic agents that neutralize tumor necrosis factor in the mucosa of patients with inflammatory bowel disease","author":"Biancheri","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.autrev.2015.08.004_bb0600","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1136\/gut.2007.130922","article-title":"Blockade of transforming growth factor beta upregulates T-box transcription factor T-bet, and increases T helper cell type 1 cytokine and matrix metalloproteinase-3 production in the human gut mucosa","volume":"57","author":"Di Sabatino","year":"2008","journal-title":"Gut"},{"key":"10.1016\/j.autrev.2015.08.004_bb0605","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1172\/JCI12821","article-title":"Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease","volume":"108","author":"Monteleone","year":"2001","journal-title":"J Clin Invest"},{"key":"10.1016\/j.autrev.2015.08.004_bb0610","doi-asserted-by":"crossref","first-page":"187","DOI":"10.2174\/187152811795564028","article-title":"Interleukin-25 negatively controls pathogenic responses in the gut","volume":"10","author":"Franz\u00e8","year":"2011","journal-title":"Inflamm Allergy Drug Targets"},{"key":"10.1016\/j.autrev.2015.08.004_bb0615","first-page":"534","article-title":"IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis","volume":"118","author":"Sugimoto","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1016\/j.autrev.2015.08.004_bb0620","doi-asserted-by":"crossref","first-page":"3454","DOI":"10.4049\/jimmunol.0802887","article-title":"Targeting gut T cell Ca2+ release-activated Ca2+ channels inhibits T cell cytokine production and T-box transcription factor T-bet in inflammatory bowel disease","volume":"183","author":"Di Sabatino","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0625","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.4049\/jimmunol.157.3.1261","article-title":"Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5","volume":"157","author":"Fuss","year":"1996","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0630","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.gastro.2005.05.002","article-title":"Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution","volume":"129","author":"Heller","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.autrev.2015.08.004_bb0635","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S1074-7613(02)00453-3","article-title":"Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells","volume":"17","author":"Heller","year":"2002","journal-title":"Immunity"},{"key":"10.1016\/j.autrev.2015.08.004_bb0640","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1002\/eji.201343524","article-title":"Absence of a role for interleukin-13 in inflammatory bowel disease","volume":"44","author":"Biancheri","year":"2014","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0645","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1136\/gutjnl-2014-308004","article-title":"Tralokinumab for moderate-to-severe UC: a randomised, double-blind, placebo-controlled, phase IIa study","volume":"64","author":"Danese","year":"2015","journal-title":"Gut"},{"key":"10.1016\/j.autrev.2015.08.004_bb0650","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1136\/gutjnl-2014-308337","article-title":"Anrukinzumab, an anti-interleukin 13 monoclonal antibody, in active UC: efficacy and safety from a phase IIa randomised multicentre study","volume":"64","author":"Reinisch","year":"2015","journal-title":"Gut"},{"key":"10.1016\/j.autrev.2015.08.004_bb0655","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.gtc.2014.05.006","article-title":"An update on anti-TNF agents in ulcerative colitis","volume":"43","author":"Samaan","year":"2014","journal-title":"Gastroenterol Clin North Am"},{"key":"10.1016\/j.autrev.2015.08.004_bb0660","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1056\/NEJMoa1112168","article-title":"Tofacitinib, an oral Janus kinase inhibitor, in active ulcerative colitis","volume":"367","author":"Sandborn","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1016\/j.autrev.2015.08.004_bb0665","first-page":"97","article-title":"Human mucosal addressin cell adhesion molecule-1 is preferentially expressed in intestinal tract and associated with lymphoid tissue","volume":"151","author":"Briskin","year":"1997","journal-title":"Am J Pathol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0670","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1136\/gut.45.6.856","article-title":"Expression of lymphocyte-endothelial receptor ligand pairs, \u03b14\u03b27\/MAdCAM 1 and OX40\/OX40 ligand in the colon and jejunum of patients with inflammatory bowel disease","volume":"45","author":"Souza","year":"1999","journal-title":"Gut"},{"key":"10.1016\/j.autrev.2015.08.004_bb0675","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1097\/MIB.0000000000000396","article-title":"Vedolizumab for induction and maintenance of remission in ulcerative colitis: a Cochrane systematic review and meta-analysis","volume":"21","author":"Mosli","year":"2015","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.autrev.2015.08.004_bb0680","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0140-6736(14)60661-9","article-title":"Etrolizumab as induction therapy for ulcerative colitis: a randomised, controlled, phase 2 trial","volume":"384","author":"Vermeire","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.autrev.2015.08.004_bb0685","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.cytogfr.2014.11.009","article-title":"CXCR3 ligands in disease and therapy","volume":"26","author":"Van Raemdonck","year":"2015","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.autrev.2015.08.004_bb0690","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0002-9440(10)65128-0","article-title":"Increased expression of IP-10, IL-8, MCP-1, and MCP-3 in ulcerative colitis","volume":"155","author":"Uguccioni","year":"1999","journal-title":"Am J Pathol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0695","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1136\/gutjnl-2012-303424","article-title":"Anti-IP-10 antibody (BMS-936557) for ulcerative colitis: a phase II randomised study","volume":"63","author":"Mayer","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.autrev.2015.08.004_bb0700","doi-asserted-by":"crossref","first-page":"G1163","DOI":"10.1152\/ajpgi.00292.2011","article-title":"Serpin B1 protects colonic epithelial cell via blockage of neutrophil elastase activity and its expression is enhanced in patients with ulcerative colitis","volume":"302","author":"Uchiyama","year":"2012","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0705","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1097\/MOG.0000000000000042","article-title":"Proteases and small intestinal barrier function in health and disease","volume":"30","author":"Giuffrida","year":"2014","journal-title":"Curr Opin Gastroenterol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0710","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1136\/gutjnl-2013-305947","article-title":"IL-9 and its receptor are predominantly involved in the pathogenesis of UC","volume":"64","author":"Nalleweg","year":"2015","journal-title":"Gut"},{"key":"10.1016\/j.autrev.2015.08.004_bb0715","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/MCG.0000000000000253","article-title":"Peroxisome proliferator-activated receptor gamma in the colon: inflammation and innate antimicrobial immunity","volume":"48","author":"Speca","year":"2014","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0720","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1053\/j.gastro.2007.12.012","article-title":"Rosiglitazone for active ulcerative colitis: a randomized placebo-controlled trial","volume":"134","author":"Lewis","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.autrev.2015.08.004_bb0725","first-page":"587","article-title":"Comparison of anti-inflammatory properties of peroxisome proliferator-activated receptor gamma agonists rosiglitazone and troglitazone in prophylactic treatment of experimental colitis","volume":"64","author":"Celinski","year":"2013","journal-title":"J Physiol Pharmacol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0730","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1159\/000336702","article-title":"The role of autoantibodies in inflammatory bowel disease","volume":"30","author":"Hersz\u00e9nyi","year":"2012","journal-title":"Dig Dis"},{"key":"10.1016\/j.autrev.2015.08.004_bb0735","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/ibd.20054","article-title":"Predictors of early response to infliximab in patients with ulcerative colitis","volume":"13","author":"Ferrante","year":"2007","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.autrev.2015.08.004_bb0740","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1136\/gut.49.5.671","article-title":"High level perinuclear antineutrophil cytoplasmic antibody (pANCA) in ulcerative colitis patients before colectomy predicts the development of chronic pouchitis after ileal pouch-anal anastomosis","volume":"49","author":"Fleshner","year":"2001","journal-title":"Gut"},{"key":"10.1016\/j.autrev.2015.08.004_bb0745","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/j.1440-1827.2012.02807.x","article-title":"Development of ulcerative colitis and its associated colorectal neoplasia as a model of the organ-specific chronic inflammation\u2013carcinoma sequence","volume":"62","author":"Okayasu","year":"2012","journal-title":"Pathol Int"},{"key":"10.1016\/j.autrev.2015.08.004_bb0750","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.cgh.2012.01.010","article-title":"Risk of colorectal cancer in patients with ulcerative colitis: a meta-analysis of population-based cohort studies","volume":"10","author":"Jess","year":"2012","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0755","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ccr.2009.01.001","article-title":"IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer","volume":"15","author":"Grivennikov","year":"2009","journal-title":"Cancer Cell"},{"key":"10.1016\/j.autrev.2015.08.004_bb0760","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.immuni.2004.07.020","article-title":"TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 transsignaling","volume":"21","author":"Becker","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.autrev.2015.08.004_bb0765","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.cytogfr.2006.09.003","article-title":"Interleukin-6 trans-signaling in inflammatory bowel disease","volume":"17","author":"Mitsuyama","year":"2006","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.autrev.2015.08.004_bb0770","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.coi.2003.09.004","article-title":"Negative regulation of cytokine signaling influences inflammation","volume":"15","author":"Yoshimura","year":"2003","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.autrev.2015.08.004_bb0775","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1136\/gut.2009.184176","article-title":"Disease-related expression of the IL6\/STAT3\/SOCS3 signalling pathway in ulcerative colitis and ulcerative colitis-related carcinogenesis","volume":"59","author":"Li","year":"2010","journal-title":"Gut"}],"container-title":["Autoimmunity Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568997215001792?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568997215001792?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,13]],"date-time":"2023-08-13T02:53:33Z","timestamp":1691895213000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568997215001792"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":149,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S1568997215001792"],"URL":"https:\/\/doi.org\/10.1016\/j.autrev.2015.08.004","relation":{},"ISSN":["1568-9972"],"issn-type":[{"value":"1568-9972","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"New insights into immune mechanisms underlying autoimmune diseases of the gastrointestinal tract","name":"articletitle","label":"Article Title"},{"value":"Autoimmunity Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.autrev.2015.08.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}