{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T01:46:20Z","timestamp":1788572780207,"version":"build-2803163510"},"reference-count":44,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Autoimmunity Reviews"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.autrev.2016.07.036","type":"journal-article","created":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T08:18:35Z","timestamp":1470212315000},"page":"1062-1070","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"title":["Retinoid-related orphan receptor \u03b3 (ROR\u03b3) adult induced knockout mice develop lymphoblastic lymphoma"],"prefix":"10.1016","volume":"15","author":[{"given":"Maria","family":"Liljevald","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Rehnberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"S\u00f6derberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Ramneg\u00e5rd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"B\u00f6rjesson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donatella","family":"Luciani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Krutr\u00f6k","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Br\u00e4nd\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Johansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiufeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Bjursell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Karin","family":"Sj\u00f6gren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorrit","family":"Hornberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Keeling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Jirholt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.autrev.2016.07.036_bb0005","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/ni0606-539","article-title":"Origins of the T(H)1-T(H)2 model: a personal perspective","volume":"7","author":"Coffman","year":"2006","journal-title":"Nat Immunol"},{"key":"10.1016\/j.autrev.2016.07.036_bb0010","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/nature01355","article-title":"Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain","volume":"421","author":"Cua","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.autrev.2016.07.036_bb0015","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1084\/jem.20041257","article-title":"IL-23 drives a pathogenic T cell population that induces autoimmune inflammation","volume":"201","author":"Langrish","year":"2005","journal-title":"J Exp Med"},{"key":"10.1016\/j.autrev.2016.07.036_bb0020","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.cell.2006.07.035","article-title":"The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells","volume":"126","author":"Ivanov","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.autrev.2016.07.036_bb0025","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/cmdc.201500432","article-title":"Benzoxazepines achieve potent suppression of IL-17 release in human T-helper 17 (TH17) cells through an induced-fit binding mode to the nuclear receptor ROR\u03b3","volume":"11","author":"Olsson","year":"2016","journal-title":"ChemMedChem"},{"key":"10.1016\/j.autrev.2016.07.036_bb0030","doi-asserted-by":"crossref","first-page":"5871","DOI":"10.1021\/jm401901d","article-title":"Modulators of the nuclear receptor retinoic acid receptor-related orphan receptor-gamma (RORgamma or RORc)","volume":"57","author":"Fauber","year":"2014","journal-title":"J Med Chem"},{"key":"10.1016\/j.autrev.2016.07.036_bb0035","doi-asserted-by":"crossref","first-page":"5013","DOI":"10.1074\/jbc.M109.080614","article-title":"Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands","volume":"285","author":"Wang","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.autrev.2016.07.036_bb0040","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nchembio.1714","article-title":"Corrigendum: sterol metabolism controls TH17 differentiation by generating endogenous RORgamma agonists","volume":"11","author":"Hu","year":"2015","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.autrev.2016.07.036_bb0045","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.1002\/eji.201545712","article-title":"Nuclear hormone receptors put immunity on sterols","volume":"45","author":"Santori","year":"2015","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.autrev.2016.07.036_bb0050","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1210\/me.2009-0507","article-title":"Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORgamma","volume":"24","author":"Jin","year":"2010","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.autrev.2016.07.036_bb0055","doi-asserted-by":"crossref","first-page":"e003","DOI":"10.1621\/nrs.07003","article-title":"Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism","volume":"7","author":"Jetten","year":"2009","journal-title":"Nucl Recept Signal"},{"key":"10.1016\/j.autrev.2016.07.036_bb0060","doi-asserted-by":"crossref","first-page":"5668","DOI":"10.4049\/jimmunol.164.11.5668","article-title":"Down-regulation of the orphan nuclear receptor ROR gamma t is essential for T lymphocyte maturation","volume":"164","author":"He","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2016.07.036_bb0065","doi-asserted-by":"crossref","first-page":"10132","DOI":"10.1073\/pnas.97.18.10132","article-title":"Retinoid-related orphan receptor gamma (RORgamma) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesis","volume":"97","author":"Kurebayashi","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.autrev.2016.07.036_bb0070","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1126\/science.288.5475.2369","article-title":"Requirement for RORgamma in thymocyte survival and lymphoid organ development","volume":"288","author":"Sun","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.autrev.2016.07.036_bb0075","doi-asserted-by":"crossref","first-page":"4259","DOI":"10.1038\/ncomms5259","article-title":"IL-23 promotes TCR-mediated negative selection of thymocytes through the upregulation of IL-23 receptor and RORgammat","volume":"5","author":"Li","year":"2014","journal-title":"Nat Commun"},{"key":"10.1016\/j.autrev.2016.07.036_bb0080","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.immuni.2006.01.001","article-title":"TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells","volume":"24","author":"Veldhoen","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.autrev.2016.07.036_bb0085","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nature04753","article-title":"Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells","volume":"441","author":"Bettelli","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.autrev.2016.07.036_bb0090","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nature04754","article-title":"Transforming growth factor-beta induces development of the T(H)17 lineage","volume":"441","author":"Mangan","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.autrev.2016.07.036_bb0095","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1084\/jem.20110462","article-title":"The Th17 immune response is controlled by the Rel-RORgamma-RORgamma T transcriptional axis","volume":"208","author":"Ruan","year":"2011","journal-title":"J Exp Med"},{"key":"10.1016\/j.autrev.2016.07.036_bb0105","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/nrd3794","article-title":"Targeting IL-17 and TH17 cells in chronic inflammation","volume":"11","author":"Miossec","year":"2012","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.autrev.2016.07.036_bb0110","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.jaut.2012.06.002","article-title":"Genetic variations in interleukin-12 related genes in immune-mediated diseases","volume":"39","author":"van Wanrooij","year":"2012","journal-title":"J Autoimmun"},{"key":"10.1016\/j.autrev.2016.07.036_bb0115","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jaut.2015.07.008","article-title":"The immunogenetics of Psoriasis: a comprehensive review","volume":"64","author":"Harden","year":"2015","journal-title":"J Autoimmun"},{"key":"10.1016\/j.autrev.2016.07.036_bb0120","doi-asserted-by":"crossref","DOI":"10.1186\/s12865-015-0070-7","article-title":"IL-17 and IL-23 in lupus nephritis \u2013 association to histopathology and response to treatment","volume":"16","author":"Zickert","year":"2015","journal-title":"BMC Immunol"},{"key":"10.1016\/j.autrev.2016.07.036_bb0125","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1182\/blood-2009-12-255810","article-title":"Th17\/Treg ratio in human graft-versus-host disease","volume":"116","author":"Ratajczak","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.autrev.2016.07.036_bb0130","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.2353\/ajpath.2009.090319","article-title":"Systemic and local interleukin-17 and linked cytokines associated with Sjogren's syndrome immunopathogenesis","volume":"175","author":"Katsifis","year":"2009","journal-title":"Am J Pathol"},{"key":"10.1016\/j.autrev.2016.07.036_bb0135","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.it.2011.08.003","article-title":"Deciphering the role of Th17 cells in human disease","volume":"32","author":"Wilke","year":"2011","journal-title":"Trends Immunol"},{"key":"10.1016\/j.autrev.2016.07.036_bb0140","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/nrrheum.2015.128","article-title":"The IL-23-IL-17 axis in inflammatory arthritis","volume":"11","author":"Lubberts","year":"2015","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.autrev.2016.07.036_bb0145","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nri3707","article-title":"The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing","volume":"14","author":"Gaffen","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.autrev.2016.07.036_bb0150","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1126\/science.aaa4282","article-title":"IMMUNODEFICIENCIES. Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations","volume":"349","author":"Okada","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.autrev.2016.07.036_bb0155","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.jaut.2012.09.002","article-title":"Epigenetics, autoimmunity and hematologic malignancies: a comprehensive review","volume":"39","author":"Ngalamika","year":"2012","journal-title":"J Autoimmun"},{"key":"10.1016\/j.autrev.2016.07.036_bb0160","first-page":"901","article-title":"High incidence of T-cell lymphomas in mice deficient in the retinoid-related orphan receptor RORgamma","volume":"62","author":"Ueda","year":"2002","journal-title":"Cancer Res"},{"key":"10.1016\/j.autrev.2016.07.036_bb0165","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/ni1022","article-title":"An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells","volume":"5","author":"Eberl","year":"2004","journal-title":"Nat Immunol"},{"key":"10.1016\/j.autrev.2016.07.036_bb0170","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/nature01262","article-title":"Initial sequencing and comparative analysis of the mouse genome","volume":"420","author":"Mouse Genome Sequencing Consortium","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.autrev.2016.07.036_bb0175","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000112","article-title":"Mouse genome sequencing consortium, lineage-specific biology revealed by a finished genome assembly of the mouse","volume":"7","author":"Church","year":"2009","journal-title":"PLoS Biol"},{"key":"10.1016\/j.autrev.2016.07.036_bb0180","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1101\/gr.229102","article-title":"The human genome browser at UCSC","volume":"12","author":"Kent","year":"2002","journal-title":"Genome Res"},{"key":"10.1016\/j.autrev.2016.07.036_bb0185","doi-asserted-by":"crossref","first-page":"10887","DOI":"10.1073\/pnas.93.20.10887","article-title":"Ligand-activated site-specific recombination in mice","volume":"93","author":"Feil","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"178","key":"10.1016\/j.autrev.2016.07.036_bb0190","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-540-35109-2_1","article-title":"Conditional somatic mutagenesis in the mouse using site-specific recombinases","author":"Feil","year":"2007","journal-title":"Handb Exp Pharmacol"},{"key":"10.1016\/j.autrev.2016.07.036_bb0195","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gng012","article-title":"Rapid generation of inducible mouse mutants","volume":"31","author":"Seibler","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.autrev.2016.07.036_bb0200","doi-asserted-by":"crossref","first-page":"14559","DOI":"10.1073\/pnas.94.26.14559","article-title":"Spatio-temporally controlled site-specific somatic mutagenesis in the mouse","volume":"94","author":"Brocard","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.autrev.2016.07.036_bb0205","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/5007","article-title":"Generalized lacZ expression with the ROSA26 Cre reporter strain","volume":"21","author":"Soriano","year":"1999","journal-title":"Nat Genet"},{"key":"10.1016\/j.autrev.2016.07.036_bb0210","doi-asserted-by":"crossref","first-page":"3789","DOI":"10.1073\/pnas.94.8.3789","article-title":"Disruption of overlapping transcripts in the ROSA beta geo 26 gene trap strain leads to widespread expression of beta-galactosidase in mouse embryos and hematopoietic cells","volume":"94","author":"Zambrowicz","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.autrev.2016.07.036_bb0215","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.bbrc.2006.07.090","article-title":"G protein-coupled receptor 12 deficiency results in dyslipidemia and obesity in mice","volume":"348","author":"Bjursell","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.autrev.2016.07.036_bb0220","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.bbrc.2006.08.103","article-title":"Phenotypic screening of hepatocyte nuclear factor (HNF) 4-gamma receptor knockout mice","volume":"349","author":"Gerdin","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.autrev.2016.07.036_bb0225","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1038\/ng.3415","article-title":"Integrated molecular analysis of adult T cell leukemia\/lymphoma","volume":"47","author":"Kataoka","year":"2015","journal-title":"Nat Genet"}],"container-title":["Autoimmunity Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568997216301811?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568997216301811?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,10]],"date-time":"2019-02-10T13:50:12Z","timestamp":1549806612000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568997216301811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":44,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["S1568997216301811"],"URL":"https:\/\/doi.org\/10.1016\/j.autrev.2016.07.036","relation":{},"ISSN":["1568-9972"],"issn-type":[{"value":"1568-9972","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Retinoid-related orphan receptor \u03b3 (ROR\u03b3) adult induced knockout mice develop lymphoblastic lymphoma","name":"articletitle","label":"Article Title"},{"value":"Autoimmunity Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.autrev.2016.07.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}