{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:15:38Z","timestamp":1790194538924,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Autoimmunity Reviews"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.autrev.2017.10.007","type":"journal-article","created":{"date-parts":[[2017,10,14]],"date-time":"2017-10-14T21:01:44Z","timestamp":1508014904000},"page":"1230-1236","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"title":["HLA-DRB1 alleles and juvenile idiopathic arthritis: Diagnostic clues emerging from a meta-analysis"],"prefix":"10.1016","volume":"16","author":[{"given":"Annalisa","family":"De Silvestri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Capittini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitri","family":"Poddighe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Luigi","family":"Marseglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Mascaretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Bevilacqua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Scotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Rebuffi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Pasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miryam","family":"Martinetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmine","family":"Tinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.autrev.2017.10.007_bb0005","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1016\/S0140-6736(11)60244-4","article-title":"Juvenile idiopathic arthritis","volume":"37","author":"Prakken","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.autrev.2017.10.007_bb0010","unstructured":"Brewer EJ Jr, Bass JC, Baum J, Cassidy JT, Fink C, Jacobs J, et al. Current proposed revision of JRA criteria. JRA criteria subcommittee of the Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Arthritis Rheum 1977; 20(2):195\u20139."},{"issue":"2","key":"10.1016\/j.autrev.2017.10.007_bb0015","first-page":"390","article-title":"International League of Associations for Rheumatology. International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001","volume":"31","author":"Petty","year":"2004","journal-title":"J Rheumatol"},{"key":"10.1016\/j.autrev.2017.10.007_bb0020","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jaut.2014.01.009","article-title":"Diagnosis and classification of juvenile idiopathic arthritis","volume":"48-49","author":"Eisenstein","year":"2014","journal-title":"J Autoimmun"},{"key":"10.1016\/j.autrev.2017.10.007_bb0025","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1136\/adc.77.6.530","article-title":"Pathogenesis of juvenile chronic arthritis: genetic and environmental factors","volume":"77","author":"Murray","year":"1997","journal-title":"Arch Dis Child"},{"issue":"11","key":"10.1016\/j.autrev.2017.10.007_bb0030","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1002\/1529-0131(199911)42:11<2261::AID-ANR1>3.0.CO;2-P","article-title":"Juvenile rheumatoid arthritis as a complex genetic trait","volume":"42","author":"Glass","year":"1999","journal-title":"Arthritis and Rheumatism"},{"issue":"1","key":"10.1016\/j.autrev.2017.10.007_bb0035","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s12026-016-8817-7","article-title":"HLA-DRB1 the notorious gene in the mosaic of autoimmunity","volume":"65","author":"Arango","year":"2017","journal-title":"Immunol Res"},{"key":"10.1016\/j.autrev.2017.10.007_bb0040","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/nrrheum.2009.209","article-title":"Oligoarticular and polyarticular JIA: epidemiology and pathogenesis","volume":"5","author":"Macaubas","year":"2009","journal-title":"Nat Rev Rheumatol"},{"issue":"5","key":"10.1016\/j.autrev.2017.10.007_bb0045","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1097\/BOR.0000000000000094","article-title":"Genetics of JIA: new tools bring new approaches","volume":"26","author":"Moncrieffe","year":"2014","journal-title":"Cure Opin Rheumatol"},{"key":"10.1016\/j.autrev.2017.10.007_bb0050","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jaut.2015.08.002","article-title":"Immunogenetics of juvenile idiopathic arthritis: a comprehensive review","volume":"64","author":"Hersh","year":"2015","journal-title":"J Autoimmun"},{"issue":"10","key":"10.1016\/j.autrev.2017.10.007_bb0055","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.jclinepi.2009.06.005","article-title":"Altman DG; PRISMA group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"62","author":"Moher","year":"2009","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.autrev.2017.10.007_bb0060","author":"De Silvestri"},{"issue":"11","key":"10.1016\/j.autrev.2017.10.007_bb0065","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Stat Med"},{"issue":"4","key":"10.1016\/j.autrev.2017.10.007_bb0070","first-page":"719","article-title":"Statistical aspects of the analysis of data from retrospective studies of disease","volume":"22","author":"Mantel","year":"1959","journal-title":"J Natl Cancer Inst"},{"issue":"3","key":"10.1016\/j.autrev.2017.10.007_bb0075","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"Der Simonian","year":"1986","journal-title":"Control Clin Trials"},{"key":"10.1016\/j.autrev.2017.10.007_bb0080","first-page":"386","article-title":"Prognostic factors in juvenile rheumatoid arthritis: a case-control study revealing early predictors and outcome after 14.9years","volume":"30","author":"Flato","year":"2003","journal-title":"J Rheumatol"},{"key":"10.1016\/j.autrev.2017.10.007_bb0085","doi-asserted-by":"crossref","first-page":"642","DOI":"10.3899\/jrheum.080543","article-title":"Juvenile psoriatic arthritis: longterm outcome and differentiation from other subtypes of juvenile idiopathic arthritis","volume":"36","author":"Flato","year":"2009","journal-title":"J Rheumatol"},{"key":"10.1016\/j.autrev.2017.10.007_bb0090","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1002\/art.10146","article-title":"The influence of patient characteristics, disease variables, and HLA alleles on the development of radiographically evident sacroileiitis in juvenile idiopathic arthritis","volume":"46","author":"Flato","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.autrev.2017.10.007_bb0095","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.humimm.2004.01.016","article-title":"HLA-DRB1 alleles and HLA-DRB1 shared epitopes are markers for juvenile rheumatoid arthritis subgroups in Colombian mestizos","volume":"65","author":"Garavito","year":"2004","journal-title":"Hum Immunol"},{"key":"10.1016\/j.autrev.2017.10.007_bb0100","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0198-8859(94)90040-X","article-title":"Susceptible and protective major histocompatibility complex class II alleles in early-onset pauciarticular juvenile chronic arthritis","volume":"41","author":"Haas","year":"1994","journal-title":"Hum Immunol"},{"key":"10.1016\/j.autrev.2017.10.007_bb0105","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1002\/art.27424","article-title":"Juvenile idiopathic arthritis and HLA class I and class II interactions and age-at-onset effects","volume":"62","author":"Hollenbach","year":"2010","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.autrev.2017.10.007_bb0110","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0198-8859(95)00063-A","article-title":"Association to HLA-DRB1*08, HLA-DPB1*0301 and homozygosity for an HLA-linked proteasome gene in juvenile ankylosing spondylitis","volume":"44","author":"Ploski","year":"1995","journal-title":"Hum Immunol"},{"key":"10.1016\/j.autrev.2017.10.007_bb0115","first-page":"124","article-title":"Association of HLA DRB1 alleles with juvenile idiopathic arthritis in Mexicans","volume":"28","author":"Silva-Ramirez","year":"2010","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.autrev.2017.10.007_bb0120","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1136\/ard.61.4.354","article-title":"Juvenile idiopathic arthritis (JIA) is primarily associated with HLA-DR8 but not DQ4 on the DR8-DQ4 haplotype","volume":"61","author":"Smerdel","year":"2002","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"10.1016\/j.autrev.2017.10.007_bb0125","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1136\/annrheumdis-2016-210025","article-title":"Fine-mapping the MHC locus in juvenile idiopathic arthritis (JIA) reveals genetic heterogeneity corresponding to distinct adult inflammatory arthritic diseases","volume":"76","author":"Hinks","year":"2016","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"10.1016\/j.autrev.2017.10.007_bb0130","first-page":"205","article-title":"Associations in juvenile arthritis","volume":"12","author":"Fernandez-Vina","year":"1994","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.autrev.2017.10.007_bb0135","first-page":"1146","article-title":"Role of HLA-DRB1 and PTPN22 genes in susceptibility to juvenile idiopathic arthritis in Hungarian patients","volume":"26","author":"Paz\u00e1r","year":"2008","journal-title":"Clin Exp Rheumatol"},{"issue":"10","key":"10.1016\/j.autrev.2017.10.007_bb0140","doi-asserted-by":"crossref","first-page":"6043","DOI":"10.1167\/iovs.15-17168","article-title":"HLA associations in a cohort of children with juvenile idiopathic arthritis with and without uveitis","volume":"56","author":"Angeles-Han","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"52","key":"10.1016\/j.autrev.2017.10.007_bb0145","doi-asserted-by":"crossref","first-page":"15970","DOI":"10.1073\/pnas.1520779112","article-title":"HLA-DRB1*11 and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis","volume":"112","author":"Ombrello","year":"2015","journal-title":"PNAS"}],"container-title":["Autoimmunity Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568997217302574?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568997217302574?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,26]],"date-time":"2018-08-26T22:28:55Z","timestamp":1535322535000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568997217302574"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["S1568997217302574"],"URL":"https:\/\/doi.org\/10.1016\/j.autrev.2017.10.007","relation":{},"ISSN":["1568-9972"],"issn-type":[{"value":"1568-9972","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HLA-DRB1 alleles and juvenile idiopathic arthritis: Diagnostic clues emerging from a meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Autoimmunity Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.autrev.2017.10.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}