{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T07:16:03Z","timestamp":1768720563737,"version":"3.49.0"},"reference-count":123,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Basic Research Program 973 Grants","award":["2015CB553704"],"award-info":[{"award-number":["2015CB553704"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Autoimmunity Reviews"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.autrev.2018.02.014","type":"journal-article","created":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T06:29:00Z","timestamp":1531290540000},"page":"845-853","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["ACPA mediates the interplay between innate and adaptive immunity in rheumatoid arthritis"],"prefix":"10.1016","volume":"17","author":[{"given":"Xiwen","family":"Dong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaohui","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianli","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.autrev.2018.02.014_bb0005","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.0105-2896.2009.00853.x","article-title":"Antibodies to citrullinated proteins: molecular interactions and arthritogenicity","volume":"233","author":"Uysal","year":"2010","journal-title":"Immunol Rev"},{"key":"10.1016\/j.autrev.2018.02.014_bb0010","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/nrrheum.2011.204","article-title":"The influence of ACPA status and characteristics on the course of RA","volume":"8","author":"Willemze","year":"2012","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.autrev.2018.02.014_bb0015","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1172\/JCI1316","article-title":"Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies","volume":"101","author":"Schellekens","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1016\/j.autrev.2018.02.014_bb0020","first-page":"659","article-title":"Rheumatoid arthritis","volume":"373","author":"Schmidt","year":"2009","journal-title":"Sykepl Fag"},{"key":"10.1016\/j.autrev.2018.02.014_bb0025","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1136\/ard.2003.016808","article-title":"Anti-CCP antibody test predicts the disease course during 3\u202fyears in early rheumatoid arthritis (the Swedish TIRA project)","volume":"63","author":"Kastbom","year":"2004","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2018.02.014_bb0030","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1002\/art.27584","article-title":"2010 rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative","volume":"62","author":"Aletaha","year":"2010","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.autrev.2018.02.014_bb0035","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1084\/jem.60.5.559","article-title":"The antibody response of rabbits to injections of emulsions and extracts of homologous brain","volume":"60","author":"Schwentker","year":"1934","journal-title":"J Exp Med"},{"key":"10.1016\/j.autrev.2018.02.014_bb0040","first-page":"665","article-title":"Auto-antibodies in the pathogenesis of disease; a preliminary study of auto-sensitization of red cells in various diseases","volume":"25","author":"Zoutendyk","year":"1951","journal-title":"S Afr Med J"},{"key":"10.1016\/j.autrev.2018.02.014_bb0045","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.autrev.2015.01.013","article-title":"Citrullination and autoimmunity","volume":"14","author":"Valesini","year":"2015","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.autrev.2018.02.014_bb0050","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s00726-005-0235-4","article-title":"Almost all about citrulline in mammals","volume":"29","author":"Curis","year":"2005","journal-title":"Amino Acids"},{"key":"10.1016\/j.autrev.2018.02.014_bb0055","doi-asserted-by":"crossref","first-page":"5","DOI":"10.4049\/jimmunol.1501021","article-title":"Citrullination: a specific target for the autoimmune response in rheumatoid arthritis","volume":"195","author":"Fox","year":"2015","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2018.02.014_bb0060","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1016\/j.biocel.2006.03.008","article-title":"Citrullination: a posttranslational modification in health and disease","volume":"38","author":"Gyorgy","year":"2006","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.autrev.2018.02.014_bb0065","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1177\/0961203314560005","article-title":"Fingerprinting of anti-citrullinated protein antibodies (ACPA): specificity, isotypes and subclasses","volume":"24","author":"Pratesi","year":"2015","journal-title":"Lupus"},{"key":"10.1016\/j.autrev.2018.02.014_bb0070","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1136\/ard.2011.151712","article-title":"Peptidylarginine deiminase 2, 3 and 4 have distinct specificities against cellular substrates: novel insights into autoantigen selection in rheumatoid arthritis","volume":"71","author":"Darrah","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2018.02.014_bb0075","first-page":"829","article-title":"The human peptidylarginine deiminases type 2 and type 4 have distinct substrate specificities","volume":"2014","author":"Assohou-Luty","year":"1844","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.autrev.2018.02.014_bb0080","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1515\/BC.2009.019","article-title":"Primary sequence, together with other factors, influence peptide deimination by peptidylarginine deiminase-4","volume":"390","author":"Stensland","year":"2009","journal-title":"Biol Chem"},{"key":"10.1016\/j.autrev.2018.02.014_bb0085","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1006\/bbrc.1998.8148","article-title":"Selective deimination of vimentin in calcium ionophore-induced apoptosis of mouse peritoneal macrophages","volume":"243","author":"Asaga","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.autrev.2018.02.014_bb0090","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nrrheum.2009.136","article-title":"Sensors of the innate immune system: their mode of action","volume":"5","author":"Baccala","year":"2009","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.autrev.2018.02.014_bb0095","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1146\/annurev.iy.12.040194.005015","article-title":"Tolerance, danger, and the extended family","volume":"12","author":"Matzinger","year":"1994","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.autrev.2018.02.014_bb0100","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.smim.2006.12.002","article-title":"Innate immune sensing of pathogens and danger signals by cell surface toll-like receptors","volume":"19","author":"Miyake","year":"2007","journal-title":"Semin Immunol"},{"key":"10.1016\/j.autrev.2018.02.014_bb0105","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.autrev.2016.12.003","article-title":"TLRs, future potential therapeutic targets for RA","volume":"16","author":"Elshabrawy","year":"2017","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.autrev.2018.02.014_bb0110","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1002\/art.22707","article-title":"Increased macrophage activation mediated through toll-like receptors in rheumatoid arthritis","volume":"56","author":"Huang","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.autrev.2018.02.014_bb0115","doi-asserted-by":"crossref","first-page":"3856","DOI":"10.1002\/art.20678","article-title":"Expression of toll-like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin-12 and interleukin-18 via interferon-gamma","volume":"50","author":"Radstake","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.autrev.2018.02.014_bb0120","doi-asserted-by":"crossref","first-page":"4965","DOI":"10.4049\/jimmunol.0801563","article-title":"Heat shock protein 96 is elevated in rheumatoid arthritis and activates macrophages primarily via TLR2 signaling","volume":"182","author":"Huang","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2018.02.014_bb0125","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1182\/blood-2012-02-404475","article-title":"NFAT control of innate immunity","volume":"120","author":"Fric","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.autrev.2018.02.014_bb0130","doi-asserted-by":"crossref","first-page":"422","DOI":"10.3389\/fimmu.2015.00422","article-title":"DAMPs from cell death to new life","volume":"6","author":"Venereau","year":"2015","journal-title":"Front Immunol"},{"key":"10.1016\/j.autrev.2018.02.014_bb0135","doi-asserted-by":"crossref","first-page":"18119","DOI":"10.1016\/S0021-9258(19)84685-9","article-title":"Ca2+-dependent deimination-induced disassembly of intermediate filaments involves specific modification of the amino-terminal head domain","volume":"264","author":"Inagaki","year":"1989","journal-title":"J Biol Chem"},{"key":"10.1016\/j.autrev.2018.02.014_bb0140","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/ncomms1676","article-title":"Corrigendum: regulation of histone modification and chromatin structure by the p53-PADI4 pathway","volume":"3","author":"Tanikawa","year":"2012","journal-title":"Nat Commun"},{"key":"10.1016\/j.autrev.2018.02.014_bb0145","doi-asserted-by":"crossref","first-page":"6692","DOI":"10.4049\/jimmunol.172.11.6692","article-title":"Nucleosomes are exposed at the cell surface in apoptosis","volume":"172","author":"Radic","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2018.02.014_bb0150","doi-asserted-by":"crossref","first-page":"159","DOI":"10.4049\/jimmunol.169.1.159","article-title":"Blebs and apoptotic bodies are B cell autoantigens","volume":"169","author":"Cocca","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2018.02.014_bb0155","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/nri.2016.147","article-title":"Programmed cell death as a defence against infection","volume":"17","author":"Jorgensen","year":"2017","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.autrev.2018.02.014_bb0160","doi-asserted-by":"crossref","first-page":"557","DOI":"10.3389\/fimmu.2016.00557","article-title":"Oxidative burst-dependent NETosis is implicated in the resolution of necrosis-associated sterile inflammation","volume":"7","author":"Biermann","year":"2016","journal-title":"Front Immunol"},{"key":"10.1016\/j.autrev.2018.02.014_bb0165","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"Brinkmann","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.autrev.2018.02.014_bb0170","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1083\/jcb.201006052","article-title":"Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps","volume":"191","author":"Papayannopoulos","year":"2010","journal-title":"J Cell Biol"},{"key":"10.1016\/j.autrev.2018.02.014_bb0175","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1083\/jcb.201203170","article-title":"Neutrophil extracellular traps: is immunity the second function of chromatin?","volume":"198","author":"Brinkmann","year":"2012","journal-title":"J Cell Biol"},{"key":"10.1016\/j.autrev.2018.02.014_bb0180","first-page":"644","article-title":"Nicotine drives neutrophil extracellular traps formation and accelerates collagen-induced arthritis","volume":"56","author":"Lee","year":"2017","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.autrev.2018.02.014_bb0185","doi-asserted-by":"crossref","first-page":"178ra40","DOI":"10.1126\/scitranslmed.3005580","article-title":"NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis","volume":"5","author":"Khandpur","year":"2013","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.autrev.2018.02.014_bb0190","doi-asserted-by":"crossref","first-page":"2840","DOI":"10.1096\/fj.13-247254","article-title":"Deimination of linker histones links neutrophil extracellular trap release with autoantibodies in systemic autoimmunity","volume":"28","author":"Dwivedi","year":"2014","journal-title":"FASEB J"},{"key":"10.1016\/j.autrev.2018.02.014_bb0195","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.4049\/jimmunol.180.3.1895","article-title":"Histone deimination as a response to inflammatory stimuli in neutrophils","volume":"180","author":"Neeli","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2018.02.014_bb0200","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1002\/art.39313","article-title":"Release of active peptidyl arginine deiminases by neutrophils can explain production of extracellular citrullinated autoantigens in rheumatoid arthritis synovial fluid","volume":"67","author":"Spengler","year":"2015","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.autrev.2018.02.014_bb0205","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.1002\/art.39283","article-title":"Local joint inflammation and histone citrullination in a murine model of the transition from preclinical autoimmunity to inflammatory arthritis","volume":"67","author":"Sohn","year":"2015","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.autrev.2018.02.014_bb0210","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.0105-2896.2009.00850.x","article-title":"Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis","volume":"233","author":"Wegner","year":"2010","journal-title":"Immunol Rev"},{"key":"10.1016\/j.autrev.2018.02.014_bb0215","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1136\/annrheumdis-2012-202765","article-title":"Antibodies from patients with rheumatoid arthritis target citrullinated histone 4 contained in neutrophils extracellular traps","volume":"73","author":"Pratesi","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2018.02.014_bb0220","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.4049\/jimmunol.1202388","article-title":"Neutrophil extracellular trap-associated protein activation of the NLRP3 inflammasome is enhanced in lupus macrophages","volume":"190","author":"Kahlenberg","year":"2013","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2018.02.014_bb0225","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1136\/annrheumdis-2015-208216","article-title":"Signs of immune activation and local inflammation are present in the bronchial tissue of patients with untreated early rheumatoid arthritis","volume":"75","author":"Reynisdottir","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2018.02.014_bb0230","article-title":"Microbial sensing by toll-like receptors and intracellular nucleic acid sensors","volume":"7","author":"Pandey","year":"2014","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.autrev.2018.02.014_bb0235","doi-asserted-by":"crossref","first-page":"13766","DOI":"10.1073\/pnas.250476497","article-title":"The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors","volume":"97","author":"Ozinsky","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.autrev.2018.02.014_bb0240","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/nri2527","article-title":"Antiviral immune responses: triggers of or triggered by autoimmunity?","volume":"9","author":"Munz","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.autrev.2018.02.014_bb0245","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.1002\/art.20584","article-title":"The presence of citrullinated proteins is not specific for rheumatoid synovial tissue","volume":"50","author":"Vossenaar","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.autrev.2018.02.014_bb0250","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1136\/ard.2005.049403","article-title":"Citrullination is an inflammation-dependent process","volume":"65","author":"Makrygiannakis","year":"2006","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2018.02.014_bb0255","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jneuroim.2014.05.007","article-title":"Localisation of citrullinated proteins in normal appearing white matter and lesions in the central nervous system in multiple sclerosis","volume":"273","author":"Bradford","year":"2014","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.autrev.2018.02.014_bb0260","doi-asserted-by":"crossref","first-page":"573","DOI":"10.2337\/db14-0621","article-title":"Citrullinated glucose-regulated protein 78 is an autoantigen in type 1 diabetes","volume":"64","author":"Rondas","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.autrev.2018.02.014_bb0265","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1093\/rheumatology\/kew178","article-title":"Autophagy generates citrullinated peptides in human synoviocytes: a possible trigger for anti-citrullinated peptide antibodies","volume":"55","author":"Sorice","year":"2016","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.autrev.2018.02.014_bb0270","doi-asserted-by":"crossref","first-page":"429","DOI":"10.4161\/auto.19261","article-title":"Processing of proteins in autophagy vesicles of antigen-presenting cells generates citrullinated peptides recognized by the immune system","volume":"8","author":"Ireland","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.autrev.2018.02.014_bb0275","doi-asserted-by":"crossref","first-page":"209ra150","DOI":"10.1126\/scitranslmed.3006869","article-title":"Immune-mediated pore-forming pathways induce cellular hypercitrullination and generate citrullinated autoantigens in rheumatoid arthritis","volume":"5","author":"Romero","year":"2013","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.autrev.2018.02.014_bb0280","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1046\/j.1365-2567.1998.00618.x","article-title":"Oxidation of defined antigens allows protein unfolding and increases both proteolytic processing and exposes peptide epitopes which are recognized by specific T cells","volume":"95","author":"Carrasco-Marin","year":"1998","journal-title":"Immunology"},{"key":"10.1016\/j.autrev.2018.02.014_bb0285","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1084\/jem.20131241","article-title":"A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis","volume":"210","author":"Scally","year":"2013","journal-title":"J Exp Med"},{"key":"10.1016\/j.autrev.2018.02.014_bb0290","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.2217\/nnm.11.177","article-title":"Citrullination of proteins: a common post-translational modification pathway induced by different nanoparticles in vitro and in vivo","volume":"7","author":"Mohamed","year":"2012","journal-title":"Nanomedicine (London)"},{"key":"10.1016\/j.autrev.2018.02.014_bb0295","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1136\/ard.2009.114694","article-title":"Silica exposure among male current smokers is associated with a high risk of developing ACPA-positive rheumatoid arthritis","volume":"69","author":"Stolt","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2018.02.014_bb0300","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1136\/annrheumdis-2015-208278","article-title":"Occupational exposure to textile dust increases the risk of rheumatoid arthritis: results from a Malaysian population-based case-control study","volume":"75","author":"Too","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2018.02.014_bb0305","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S0140-6736(09)60008-8","article-title":"Rheumatoid arthritis","volume":"373","author":"Klareskog","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.autrev.2018.02.014_bb0310","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1136\/annrheumdis-2013-204912","article-title":"Shared immunological targets in the lungs and joints of patients with rheumatoid arthritis: identification and validation","volume":"74","author":"Ytterberg","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2018.02.014_bb0315","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1002\/art.20553","article-title":"A gene-environment interaction between smoking and shared epitope genes in HLA-DR provides a high risk of seropositive rheumatoid arthritis","volume":"50","author":"Padyukov","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.autrev.2018.02.014_bb0320","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/art.21575","article-title":"A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination","volume":"54","author":"Klareskog","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.autrev.2018.02.014_bb0325","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1002\/art.39226","article-title":"Bronchiectasis is a model for chronic bacterial infection inducing autoimmunity in rheumatoid arthritis","volume":"67","author":"Quirke","year":"2015","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.autrev.2018.02.014_bb0330","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13075-015-0520-x","article-title":"Expression of citrulline and homocitrulline residues in the lungs of non-smokers and smokers: implications for autoimmunity in rheumatoid arthritis","volume":"17","author":"Lugli","year":"2015","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.autrev.2018.02.014_bb0335","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/nrrheum.2015.38","article-title":"Autoimmunity: lungs and citrullination","volume":"11","author":"Klareskog","year":"2015","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.autrev.2018.02.014_bb0340","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1093\/ntr\/ntw030","article-title":"Smoking and air pollution as pro-inflammatory triggers for the development of rheumatoid arthritis","volume":"18","author":"Anderson","year":"2016","journal-title":"Nicotine Tob Res"},{"key":"10.1016\/j.autrev.2018.02.014_bb0345","doi-asserted-by":"crossref","first-page":"R4","DOI":"10.1186\/gb-2013-14-1-r4","article-title":"Inflammation-associated enterotypes, host genotype, cage and inter-individual effects drive gut microbiota variation in common laboratory mice","volume":"14","author":"Hildebrand","year":"2013","journal-title":"Genome Biol"},{"key":"10.1016\/j.autrev.2018.02.014_bb0350","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.coi.2013.10.016","article-title":"The interplay between the innate immune system and the microbiota","volume":"26","author":"Thaiss","year":"2014","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.autrev.2018.02.014_bb0355","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.autrev.2016.07.012","article-title":"Microbiota at the crossroads of autoimmunity","volume":"15","author":"Shamriz","year":"2016","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.autrev.2018.02.014_bb0360","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1016\/j.cell.2015.10.048","article-title":"Microbiota-modulated metabolites shape the intestinal microenvironment by regulating NLRP6 inflammasome signaling","volume":"163","author":"Levy","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.autrev.2018.02.014_bb0365","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1097\/BOR.0000000000000008","article-title":"Microbiome and mucosal inflammation as extra-articular triggers for rheumatoid arthritis and autoimmunity","volume":"26","author":"Brusca","year":"2014","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.autrev.2018.02.014_bb0370","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1177\/0961203314531636","article-title":"Epigenetics and the microbiome: developing areas in the understanding of the aetiology of lupus","volume":"23","author":"Edwards","year":"2014","journal-title":"Lupus"},{"key":"10.1016\/j.autrev.2018.02.014_bb0375","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.immuni.2014.05.013","article-title":"Inflammatory bowel disease as a model for translating the microbiome","volume":"40","author":"Huttenhower","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.autrev.2018.02.014_bb0380","doi-asserted-by":"crossref","first-page":"1","DOI":"10.11124\/jbisrir-2012-288","article-title":"Periodontal disease as a risk factor for rheumatoid arthritis: a systematic review","volume":"10","author":"Kaur","year":"2012","journal-title":"JBI Libr Syst Rev"},{"key":"10.1016\/j.autrev.2018.02.014_bb0385","first-page":"S434","article-title":"The periodontium contains citrullinated proteins, PAD-2 enzymes and HC Gp-39","volume":"60","author":"Nesse","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.autrev.2018.02.014_bb0390","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.1002\/art.27552","article-title":"Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and alpha-enolase: implications for autoimmunity in rheumatoid arthritis","volume":"62","author":"Wegner","year":"2010","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.autrev.2018.02.014_bb0395","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1136\/ard.2005.036913","article-title":"The association between periodontal disease and joint destruction in rheumatoid arthritis extends the link between the HLA-DR shared epitope and severity of bone destruction","volume":"65","author":"Marotte","year":"2006","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2018.02.014_bb0400","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.3389\/fmicb.2016.01296","article-title":"How rheumatoid arthritis can result from provocation of the immune system by microorganisms and viruses","volume":"7","author":"Arleevskaya","year":"2016","journal-title":"Front Microbiol"},{"key":"10.1016\/j.autrev.2018.02.014_bb0405","doi-asserted-by":"crossref","first-page":"328","DOI":"10.4161\/self.1.4.13315","article-title":"No human protein is exempt from bacterial motifs, not even one","volume":"1","author":"Trost","year":"2010","journal-title":"Self Nonself"},{"key":"10.1016\/j.autrev.2018.02.014_bb0410","doi-asserted-by":"crossref","first-page":"R1421","DOI":"10.1186\/ar1845","article-title":"Identification of citrullinated alpha-enolase as a candidate autoantigen in rheumatoid arthritis","volume":"7","author":"Kinloch","year":"2005","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.autrev.2018.02.014_bb0415","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s12026-014-8584-2","article-title":"In ACPA-positive RA patients, antibodies to EBNA35-58Cit, a citrullinated peptide from the Epstein-Barr nuclear antigen-1, strongly cross-react with the peptide beta60-74Cit which bears the immunodominant epitope of citrullinated fibrin","volume":"61","author":"Cornillet","year":"2015","journal-title":"Immunol Res"},{"key":"10.1016\/j.autrev.2018.02.014_bb0420","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/nrrheum.2010.139","article-title":"Periodontitis in RA-the citrullinated enolase connection","volume":"6","author":"Lundberg","year":"2010","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.autrev.2018.02.014_bb0425","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/BF00274934","article-title":"Persistence of B19 parvovirus in synovial membranes of patients with rheumatoid arthritis","volume":"12","author":"Saal","year":"1992","journal-title":"Rheumatol Int"},{"key":"10.1016\/j.autrev.2018.02.014_bb0430","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.molimm.2015.09.010","article-title":"Peptide motif analysis predicts alphaviruses as triggers for rheumatoid arthritis","volume":"68","author":"Hogeboom","year":"2015","journal-title":"Mol Immunol"},{"key":"10.1016\/j.autrev.2018.02.014_bb0435","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s10067-016-3441-4","article-title":"Greek rheumatoid arthritis patients have elevated levels of antibodies against antigens from Proteus mirabilis","volume":"36","author":"Christopoulos","year":"2017","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.autrev.2018.02.014_bb0440","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1002\/art.39161","article-title":"Monoclonal antibody against citrullinated peptides obtained from rheumatoid arthritis patients reacts with numerous citrullinated microbial and food proteins","volume":"67","author":"Tsuda","year":"2015","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.autrev.2018.02.014_bb0445","first-page":"245","article-title":"The fingerprint of the human gastrointestinal tract microbiota: a hypothesis of molecular mapping","volume":"31","author":"Tomasello","year":"2017","journal-title":"J Biol Regul Homeost Agents"},{"key":"10.1016\/j.autrev.2018.02.014_bb0450","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/nm.3914","article-title":"The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment","volume":"21","author":"Zhang","year":"2015","journal-title":"Nat Med"},{"key":"10.1016\/j.autrev.2018.02.014_bb0455","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.pharma.2014.05.004","article-title":"Fecal microbiota transplantation: review","volume":"73","author":"Barbut","year":"2015","journal-title":"Ann Pharm Fr"},{"key":"10.1016\/j.autrev.2018.02.014_bb0460","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.autrev.2009.04.006","article-title":"Anti-citrullinated protein\/peptide autoantibodies in association with genetic and environmental factors as indicators of disease outcome in rheumatoid arthritis","volume":"9","author":"Szodoray","year":"2010","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.autrev.2018.02.014_bb0465","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1136\/ard.2006.068247","article-title":"High anti-cyclic citrullinated peptide levels and an algorithm of four variables predict radiographic progression in patients with rheumatoid arthritis: results from a 10-year longitudinal study","volume":"67","author":"Syversen","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2018.02.014_bb0470","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1136\/ard.62.2.120","article-title":"Anticitrullinated protein\/peptide antibody assays in early rheumatoid arthritis for predicting five year radiographic damage","volume":"62","author":"Meyer","year":"2003","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2018.02.014_bb0475","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1002\/1529-0131(200003)43:3<608::AID-ANR18>3.0.CO;2-G","article-title":"Induction of tumor necrosis factor alpha production by adhered human monocytes: a key role for Fcgamma receptor type IIIa in rheumatoid arthritis","volume":"43","author":"Abrahams","year":"2000","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.autrev.2018.02.014_bb0480","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1002\/art.23284","article-title":"Induction of macrophage secretion of tumor necrosis factor alpha through Fcgamma receptor IIa engagement by rheumatoid arthritis-specific autoantibodies to citrullinated proteins complexed with fibrinogen","volume":"58","author":"Clavel","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.autrev.2018.02.014_bb0485","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.autrev.2016.02.006","article-title":"Targeting FcgammaRs to treat antibody-dependent autoimmunity","volume":"15","author":"Yu","year":"2016","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.autrev.2018.02.014_bb0490","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/art.30081","article-title":"Immune complexes containing citrullinated fibrinogen costimulate macrophages via toll-like receptor 4 and Fcgamma receptor","volume":"63","author":"Sokolove","year":"2011","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.autrev.2018.02.014_bb0495","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1007\/s10753-015-0188-z","article-title":"Anti-citrullinated protein antibodies induce macrophage subset disequilibrium in RA patients","volume":"38","author":"Zhu","year":"2015","journal-title":"Inflammation"},{"key":"10.1016\/j.autrev.2018.02.014_bb0500","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1136\/annrheumdis-2015-208887","article-title":"Among human macrophages polarised to different phenotypes, the M-CSF-oriented cells present the highest pro-inflammatory response to the rheumatoid arthritis-specific immune complexes containing ACPA","volume":"75","author":"Clavel","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2018.02.014_bb0505","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1136\/annrheumdis-2014-205562","article-title":"Toll-like receptor triggering augments activation of human mast cells by anti-citrullinated protein antibodies","volume":"74","author":"Suurmond","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2018.02.014_bb0510","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.autrev.2011.04.012","article-title":"Role of the complement system in rheumatoid arthritis and psoriatic arthritis: relationship with anti-TNF inhibitors","volume":"10","author":"Ballanti","year":"2011","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.autrev.2018.02.014_bb0515","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1136\/ard.55.12.888","article-title":"Complement in acute and chronic arthritides: assessment of C3c, C9, and protectin (CD59) in synovial membrane","volume":"55","author":"Konttinen","year":"1996","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2018.02.014_bb0520","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/BF00301260","article-title":"Expression of the components and regulatory proteins of the alternative complement pathway and the membrane attack complex in normal and diseased synovium","volume":"13","author":"Guc","year":"1993","journal-title":"Rheumatol Int"},{"key":"10.1016\/j.autrev.2018.02.014_bb0525","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/cei.12097","article-title":"Genetic variants in the region of the C1q genes are associated with rheumatoid arthritis","volume":"173","author":"Trouw","year":"2013","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.autrev.2018.02.014_bb0530","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.4049\/jimmunol.177.3.1904","article-title":"Alternative complement pathway activation is essential for inflammation and joint destruction in the passive transfer model of collagen-induced arthritis","volume":"177","author":"Banda","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2018.02.014_bb0535","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1084\/jem.20070432","article-title":"A novel inhibitor of the alternative pathway of complement reverses inflammation and bone destruction in experimental arthritis","volume":"204","author":"Katschke","year":"2007","journal-title":"J Exp Med"},{"key":"10.1016\/j.autrev.2018.02.014_bb0540","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1002\/art.24622","article-title":"Anti-cyclic citrullinated peptide antibodies from rheumatoid arthritis patients activate complement via both the classical and alternative pathways","volume":"60","author":"Trouw","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.autrev.2018.02.014_bb0545","doi-asserted-by":"crossref","first-page":"R94","DOI":"10.1186\/ar2478","article-title":"Circulating immune complexes contain citrullinated fibrinogen in rheumatoid arthritis","volume":"10","author":"Zhao","year":"2008","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.autrev.2018.02.014_bb0550","doi-asserted-by":"crossref","first-page":"29080","DOI":"10.1074\/jbc.M504528200","article-title":"Human serum IgM glycosylation: identification of glycoforms that can bind to mannan-binding lectin","volume":"280","author":"Arnold","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.autrev.2018.02.014_bb0555","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1136\/annrheumdis-2012-202615","article-title":"Low-avidity anticitrullinated protein antibodies (ACPA) are associated with a higher rate of joint destruction in rheumatoid arthritis","volume":"73","author":"Suwannalai","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2018.02.014_bb0560","first-page":"4157","article-title":"Effect of bivalent interaction upon apparent antibody affinity: experimental confirmation of theory using fluorescence photobleaching and implications for antibody binding assays","volume":"52","author":"Kaufman","year":"1992","journal-title":"Cancer Res"},{"key":"10.1016\/j.autrev.2018.02.014_bb0565","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1177\/0022034513500306","article-title":"Advances in the regulation of osteoclasts and osteoclast functions","volume":"92","author":"Boyce","year":"2013","journal-title":"J Dent Res"},{"key":"10.1016\/j.autrev.2018.02.014_bb0570","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1172\/JCI60975","article-title":"Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin","volume":"122","author":"Harre","year":"2012","journal-title":"J Clin Invest"},{"key":"10.1016\/j.autrev.2018.02.014_bb0575","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1136\/annrheumdis-2015-208093","article-title":"Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritis-associated autoantibody-mediated bone loss","volume":"75","author":"Rogoz","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2018.02.014_bb0580","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/nrrheum.2016.200","article-title":"Mechanisms leading from systemic autoimmunity to joint-specific disease in rheumatoid arthritis","volume":"13","author":"Catrina","year":"2017","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.autrev.2018.02.014_bb0585","doi-asserted-by":"crossref","first-page":"4353","DOI":"10.1210\/endo.139.10.6247","article-title":"Human osteoclasts and osteoclast-like cells synthesize and release high basal and inflammatory stimulated levels of the potent chemokine interleukin-8","volume":"139","author":"Rothe","year":"1998","journal-title":"Endocrinology"},{"key":"10.1016\/j.autrev.2018.02.014_bb0590","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1242\/bio.20148128","article-title":"Autocrine signaling is a key regulatory element during osteoclastogenesis","volume":"3","author":"Kopesky","year":"2014","journal-title":"Biol Open"},{"key":"10.1016\/j.autrev.2018.02.014_bb0595","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1136\/annrheumdis-2015-208094","article-title":"Autoantibodies to citrullinated proteins induce joint pain independent of inflammation via a chemokine-dependent mechanism","volume":"75","author":"Wigerblad","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2018.02.014_bb0600","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1172\/JCI25422","article-title":"Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis","volume":"116","author":"Kuhn","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1016\/j.autrev.2018.02.014_bb0605","doi-asserted-by":"crossref","first-page":"13","DOI":"10.4049\/jimmunol.164.1.13","article-title":"Cutting edge: heat shock protein (HSP) 60 activates the innate immune response: CD14 is an essential receptor for HSP60 activation of mononuclear cells","volume":"164","author":"Kol","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2018.02.014_bb0610","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1189\/jlb.0908548","article-title":"The alarmin HMGB1 acts in synergy with endogenous and exogenous danger signals to promote inflammation","volume":"86","author":"Hreggvidsdottir","year":"2009","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.autrev.2018.02.014_bb0615","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1136\/annrheumdis-2015-208554","article-title":"Synovial fluid mononuclear cells provide an environment for long-term survival of antibody-secreting cells and promote the spontaneous production of anti-citrullinated protein antibodies","volume":"75","author":"Kerkman","year":"2016","journal-title":"Ann Rheum Dis"}],"container-title":["Autoimmunity Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568997218301551?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568997218301551?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T05:52:50Z","timestamp":1661579570000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568997218301551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":123,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["S1568997218301551"],"URL":"https:\/\/doi.org\/10.1016\/j.autrev.2018.02.014","relation":{},"ISSN":["1568-9972"],"issn-type":[{"value":"1568-9972","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ACPA mediates the interplay between innate and adaptive immunity in rheumatoid arthritis","name":"articletitle","label":"Article Title"},{"value":"Autoimmunity Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.autrev.2018.02.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}