{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:22:07Z","timestamp":1790475727523,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Autoimmunity Reviews"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.autrev.2018.10.005","type":"journal-article","created":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T22:46:27Z","timestamp":1547160387000},"page":"306-311","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":79,"title":["Innate immune-responses and their role in driving autoimmunity"],"prefix":"10.1016","volume":"18","author":[{"given":"Elias","family":"Toubi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahava","family":"Vadasz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.autrev.2018.10.005_bb0005","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1126\/science.1170540","article-title":"In-vivo analysis of dendritic cell development and homeostasis","volume":"324","author":"Liu","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.autrev.2018.10.005_bb0010","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1126\/science.1178331","article-title":"Development of monocytes, macrophages, and dendritic cells","volume":"327","author":"Geissman","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.autrev.2018.10.005_bb0015","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/imm.12504","article-title":"Contribution of dendritic cells to the autoimmune pathology of systemic lupus erythematosus","volume":"146","author":"Mackern-Oberti","year":"2015","journal-title":"Immunology"},{"key":"10.1016\/j.autrev.2018.10.005_bb0020","doi-asserted-by":"crossref","first-page":"642","DOI":"10.3389\/fphar.2018.00642","article-title":"Molecular mechanisms of T cells activation by dendritic cells in autoimmune diseases","volume":"9","author":"Tai","year":"2018","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.autrev.2018.10.005_bb0025","first-page":"17: 1","article-title":"A positive feedback loop between Th17 cells and dendritic cells, in patients with endplate inflammation","author":"Wang","year":"2018","journal-title":"Immunol Invest"},{"key":"10.1016\/j.autrev.2018.10.005_bb0030","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1093\/rheumatology\/key159","article-title":"microRNA downregulation in plasmacytoid dendritic cells in interferon-positive systemic lupus erythematosus and antiphospholipid syndrome","volume":"57","author":"van der Hoogen","year":"2018","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.autrev.2018.10.005_bb0035","doi-asserted-by":"crossref","first-page":"R29","DOI":"10.1186\/ar2382","article-title":"Dysfunctional interferon-alpha production by peripheral plasmacytoid dendritic cells upon Toll-like receptor-9 stimulation in patients with systemic lupus erythematosus","volume":"10","author":"Kwok","year":"2008","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.autrev.2018.10.005_bb0040","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1186\/s13075-017-1441-7","article-title":"Enhanced IFN-\u03b1 production is associated with increased TLR-7 retention in the lysosome of plasmacytoid dendritic cells in systemic lupus erythematosus","volume":"19","author":"Murayama","year":"2017","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.autrev.2018.10.005_bb0045","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.autrev.2017.07.001","article-title":"Does type-1 interferon drive systemic autoimmunity?","volume":"16","author":"Picard","year":"2017","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.autrev.2018.10.005_bb0050","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1002\/art.24719","article-title":"Mouse dendritic cells matured by ingestion of apoptotic blebs induce T cells to produce interleukin-17","volume":"60","author":"Fransen","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.autrev.2018.10.005_bb0055","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1080\/08916930902828049","article-title":"Both early and late blebs are taken up by DCs and induce IL-6","volume":"42","author":"Fransen","year":"2009","journal-title":"Autoimmunity"},{"key":"10.1016\/j.autrev.2018.10.005_bb0060","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1586\/1744666X.2014.944162","article-title":"The role of dead cell clearance in the etiology and pathogenesis of systemic lupus erythematosus: dendritic cells as potential targets","volume":"10","author":"Biermann","year":"2014","journal-title":"Expert Rev Clin Immunol"},{"key":"10.1016\/j.autrev.2018.10.005_bb0065","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12969-015-0007-y","article-title":"Increased soluble phagocytic receptors sMer, sTyro3 and sAx1 and reduced phagocytosis in juvenile-onset systemic lupus erythematosus","volume":"13","author":"Ballantine","year":"2015","journal-title":"Pediatr Rheumatol Online J"},{"key":"10.1016\/j.autrev.2018.10.005_bb0070","doi-asserted-by":"crossref","first-page":"R62","DOI":"10.1186\/ar3316","article-title":"Incraesed plasma levels of the soluble Mer tyrosine kinase receptor in systemic lupus erythematosus relate to disease activity and nephritis","volume":"13","author":"Wu","year":"2011","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.autrev.2018.10.005_bb0075","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/431896","article-title":"The expression and clinical significance of different forms of Mer receptor tyrosine kinase in systemic lupus erythematosus","volume":"2014","author":"Zhu","year":"2014","journal-title":"J Immunol Res"},{"key":"10.1016\/j.autrev.2018.10.005_bb0080","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.clim.2016.05.011","article-title":"Heightened cleavage of Ax1 receptor tyrosine kinase by ADAM metalloproteases may contribute to disease pathogenesis in SLE","volume":"169","author":"Orme","year":"2016","journal-title":"Clin Immunol"},{"key":"10.1016\/j.autrev.2018.10.005_bb0085","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jaut.2018.05.005","article-title":"Modulation of human Th17 cell responses through complement receptor 3 (CD11b\/CD18) ligation on monocyte-derived dendritic cells","volume":"92","author":"Nowatzky","year":"2018","journal-title":"J Autoimmun"},{"key":"10.1016\/j.autrev.2018.10.005_bb0090","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.autrev.2017.04.006","article-title":"Dysregulated homeostasis of target tissue or autoantigens \u2013 a novel principle in autoimmunity","volume":"16","author":"Peterson","year":"2017","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.autrev.2018.10.005_bb0095","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/978-1-60761-869-0_22","article-title":"Induction of tolerogenic dendritic cells by NF-kB blockade and Fc\u0264 receptor modulation","volume":"677","author":"Carrenno","year":"2011","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.autrev.2018.10.005_bb0100","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.autrev.2016.07.032","article-title":"Tolerogenic dendritis cells for reprogramming of lymphocyte responses in autoimmune diseases","volume":"15","author":"Garcia-Gonzalez","year":"2016","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.autrev.2018.10.005_bb0105","doi-asserted-by":"crossref","first-page":"5237","DOI":"10.4049\/jimmunol.1203017","article-title":"IL-17 stimulates differentiation of human anti-inflammatory macrophages and phagocytosis of apoptotic neutrophils in response to IL-10 and glucocorticoids","volume":"190","author":"Zizzo","year":"2013","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2018.10.005_bb0110","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1136\/ard.2009.126383","article-title":"Generation and characterization of therapeutic tolerogenic dendritic cells for rheumatoid arthritis","volume":"69","author":"Harry","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2018.10.005_bb0115","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1111\/imm.12806","article-title":"Autologous tolerogenic dendritic cells derived from monocytes of systemic lupus erythematosus patients and healthy donors show a stable and immunosuppressive phenotype","volume":"152","author":"Obreque","year":"2017","journal-title":"Immunology"},{"key":"10.1016\/j.autrev.2018.10.005_bb0120","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1385\/IR:30:3:261","article-title":"C-reactive protein: an activator of innate immunity and a modulator of adaptive immunity","volume":"30","author":"Du Clos","year":"2004","journal-title":"Immun Res"},{"issue":"6","key":"10.1016\/j.autrev.2018.10.005_bb0125","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.autrev.2016.02.002","article-title":"An update on biomarkers in axial spondyloarthritis","volume":"15","author":"Prajzlerov\u00e1","year":"2016","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.autrev.2018.10.005_bb0130","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1002\/eji.200323541","article-title":"A common site within factor H SCR 7 responsible for binding heparin, C-reactive protein and streptococcal M protein","volume":"33","author":"Giannakis","year":"2003","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.autrev.2018.10.005_bb0135","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1002\/art.11026","article-title":"Delayed lupus onset in (NZBxNZW) F1 mice expressing a human C-reactive protein transgene","volume":"48","author":"Szalai","year":"2003","journal-title":"Arthritis Rheum"},{"issue":"2","key":"10.1016\/j.autrev.2018.10.005_bb0140","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1002\/art.20846","article-title":"DuClos TW: C-reactive protein reverses on going proteinuria in autoimmune mice","volume":"52","author":"Rodriguez","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.autrev.2018.10.005_bb0145","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1002\/eji.200635207","article-title":"C-reactive protein impairs human CD14+ monocyte-derived dendritic cell differentiation, maturation and function","volume":"36","author":"Zhang","year":"2006","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.autrev.2018.10.005_bb0150","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1093\/ndt\/17.12.2041","article-title":"No lupus nephritis in the absence of antiC1q autoantibodies?","volume":"17","author":"V\u00e9ronique Fr\u00e9meaux\u2010Bacchi","year":"2004","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.autrev.2018.10.005_bb0155","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1053\/ajkd.2001.22071","article-title":"Anti-C1q antibodies may help in diagnosing a renal flare in lupus nephritis","volume":"37","author":"Moroni","year":"2001","journal-title":"Am J Kidney Dis"},{"issue":"2","key":"10.1016\/j.autrev.2018.10.005_bb0160","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1177\/1753425910396252","article-title":"Complement and non-complement activating functions of C1q: a prototypical innate immune molecule","volume":"18","author":"Nayak","year":"2011","journal-title":"Innate Immun"},{"key":"10.1016\/j.autrev.2018.10.005_bb0165","doi-asserted-by":"crossref","first-page":"8225","DOI":"10.4049\/jimmunol.0902642","article-title":"Autoantibodies against C1q in systemic lupus erythematosus are antigen-driven","volume":"183","author":"Schaller","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2018.10.005_bb0170","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1177\/0961203316645205","article-title":"Anti-C1q in systemic lupus erythematosus","volume":"25","author":"Stojan","year":"2016","journal-title":"Lupus"},{"key":"10.1016\/j.autrev.2018.10.005_bb0175","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.imbio.2011.11.007","article-title":"Anti-C1q autoantibodies specific against the globular domain of the C1qB-chain from patient with lupus nephritis inhibit C1q binding to IgG and CRP","volume":"217","author":"Radanovaa","year":"2012","journal-title":"Immunobiology"},{"key":"10.1016\/j.autrev.2018.10.005_bb0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-3083.2011.02663.x","article-title":"The 2011 Nobel prize in physiology or medicine","volume":"75","author":"Volchenkov","year":"2012","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.autrev.2018.10.005_bb0185","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.autrev.2016.12.003","article-title":"TLRs, future potential therapeutic targets for RA","volume":"16","author":"Elshabrawy","year":"2017","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.autrev.2018.10.005_bb0190","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/cei.13022","article-title":"Relevant genetic polymorphisms and kidney expression of Toll-like receptor (TLR)-5 and TLR-9 in lupus nephritis","volume":"190","author":"Elloumi","year":"2017","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.autrev.2018.10.005_bb0195","first-page":"585","article-title":"Toll-like receptor-9 is involved in the development of B cell stimulating factor-induced systemic lupus erythematosus","volume":"15","author":"Liu","year":"2018","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.autrev.2018.10.005_bb0200","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/imr.12383","article-title":"Endosomal Toll-like receptors in clinically overt and silent autoimmunity","volume":"269","author":"Clancy","year":"2016","journal-title":"Immunol Rev"},{"key":"10.1016\/j.autrev.2018.10.005_bb0205","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1002\/eji.200838478","article-title":"Molecular mimicry in innate immunity? The viral RNA recognition receptor TLR-7 accelerates murine lupus","volume":"38","author":"Anders","year":"2008","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.autrev.2018.10.005_bb0210","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jaut.2009.10.001","article-title":"Emerging roles of TLR-7 and TLR-9 in murine SLE","volume":"33","author":"Santiago-Raber","year":"2009","journal-title":"J Autoimmun"},{"key":"10.1016\/j.autrev.2018.10.005_bb0215","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.jaut.2009.11.001","article-title":"Critical role of TLR7 in the acceleration of systemic lupus erythematosus in TLR9-deficient mice","volume":"34","author":"Santiago-Raber","year":"2010","journal-title":"J Autoimmun"},{"key":"10.1016\/j.autrev.2018.10.005_bb0220","article-title":"Accelerated model of lupus autoimmunity and vasculopathy driven by TLR7\/9 imbalance","volume":"14","author":"Liu","year":"2018","journal-title":"Lupus Sci Med"},{"key":"10.1016\/j.autrev.2018.10.005_bb0225","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.autrev.2011.04.017","article-title":"Emerging role for NK cells in the pathogenesis of inflammatory arthropathies","volume":"10","author":"Conigliaro","year":"2011","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.autrev.2018.10.005_bb0230","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s12016-013-8400-0","article-title":"NK cell trafficking in health and autoimmunity: a comprehensive review","volume":"47","author":"Peng","year":"2014","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.autrev.2018.10.005_bb0235","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.autrev.2017.11.018","article-title":"NK cells in autoimmune diseases: linking innate and adaptive immune responses","volume":"17","author":"Gianchecchi","year":"2018","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.autrev.2018.10.005_bb0240","first-page":"1","article-title":"Disease-association of different killer cell immunoglobulin-like receptors (KIR) and HLA-C gene combinations in reactive arthritis","volume":"23","author":"Sun","year":"2018","journal-title":"Mod Rheumatol"},{"key":"10.1016\/j.autrev.2018.10.005_bb0245","article-title":"A natural killer T-cell subset that protects against airway hyper-reactivity","author":"Chuang","year":"2018","journal-title":"Allergy Clin Immunol"},{"key":"10.1016\/j.autrev.2018.10.005_bb0250","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.3389\/fimmu.2018.02082","article-title":"Complex network of NK cell subsets controls immune homeostasis in liver and gut","volume":"9","author":"Marrero","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.autrev.2018.10.005_bb0255","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.autrev.2017.07.012","article-title":"International consensus: what else can we do to improve diagnosis and therapeutic strategies in patients affected by autoimmune rheumatic diseases?. The unmet needs, and the clinical grey zone in autoimmune disease management","volume":"16","author":"Giacomelli","year":"2017","journal-title":"Autoimmun Rev"}],"container-title":["Autoimmunity Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568997219300114?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568997219300114?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T21:13:14Z","timestamp":1761599594000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568997219300114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["S1568997219300114"],"URL":"https:\/\/doi.org\/10.1016\/j.autrev.2018.10.005","relation":{},"ISSN":["1568-9972"],"issn-type":[{"value":"1568-9972","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Innate immune-responses and their role in driving autoimmunity","name":"articletitle","label":"Article Title"},{"value":"Autoimmunity Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.autrev.2018.10.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}