{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T03:57:21Z","timestamp":1782878241564,"version":"3.54.5"},"reference-count":26,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Autoimmunity Reviews"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.autrev.2018.10.006","type":"journal-article","created":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T22:46:46Z","timestamp":1547160406000},"page":"262-269","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Effectiveness and safety of rituximab for the treatment of refractory systemic sclerosis associated calcinosis: A case series and systematic review of the literature"],"prefix":"10.1016","volume":"18","author":[{"given":"Javier","family":"Narv\u00e1ez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Pablo","family":"Pirola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judi","family":"LLuch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Juarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan Miquel","family":"Nolla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Valenzuela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.autrev.2018.10.006_bb0005","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.semarthrit.2016.05.008","article-title":"Calcinosis is associated with digital ulcers and osteoporosis in patients with systemic sclerosis: a Scleroderma Clinical Trials Consortium study","volume":"46","author":"Valenzuela","year":"2016","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.autrev.2018.10.006_bb0010","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.matbio.2013.06.003","article-title":"Ectopic mineralization disorders of the extracellular matrix of connective tissue: molecular genetics and pathomechanisms of aberrant calcification","volume":"33","author":"Li","year":"2014","journal-title":"Matrix Biol"},{"key":"10.1016\/j.autrev.2018.10.006_bb0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaad.2010.08.038","article-title":"Calcinosis cutis: part I. Diagnostic pathway","volume":"65","author":"Reiter","year":"2011","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.autrev.2018.10.006_bb0020","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1097\/BOR.0000000000000220","article-title":"Calcinosis: pathophysiology and management","volume":"27","author":"Valenzuela","year":"2015","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.autrev.2018.10.006_bb0025","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1136\/ard.2010.134304","article-title":"Predictive factors of hand radiographic lesions in systemic sclerosis: a prospective study","volume":"70","author":"Avouac","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2018.10.006_bb0030","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1136\/ard.2005.044602","article-title":"Radiological hand involvement in systemic sclerosis","volume":"65","author":"Avouac","year":"2006","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2018.10.006_bb0035","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1093\/rheumatology\/kes214","article-title":"Acro-osteolysis in systemic sclerosis is associated with digital ischaemia and severe calcinosis","volume":"51","author":"Johnstone","year":"2012","journal-title":"Rheumatology"},{"key":"10.1016\/j.autrev.2018.10.006_bb0040","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.semarthrit.2010.06.008","article-title":"Hand radiological damage in systemic sclerosis: comparison with a control group and clinical and functional correlations","volume":"40","author":"Koutaissoff","year":"2011","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.autrev.2018.10.006_bb0045","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1093\/rheumatology\/kew313","article-title":"Calcinosis is associated with digital ischaemia in systemic sclerosis-a longitudinal study","volume":"55","author":"Baron","year":"2016","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.autrev.2018.10.006_bb0050","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1097\/BOR.0000000000000539","article-title":"Calcinosis in scleroderma","volume":"30","author":"Valenzuela","year":"2018","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.autrev.2018.10.006_bb0055","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1136\/annrheumdis-2013-204522","article-title":"EUSTAR Rituximab study group. Effects and safety of rituximab in systemic sclerosis: an analysis from the European Scleroderma Trial and Research (EUSTAR) group","volume":"74","author":"Jordan","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2018.10.006_bb0060","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s10067-012-2124-z","article-title":"Rituximab- induced regression of CREST- related calcinosis","volume":"32","author":"de Paula","year":"2013","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.autrev.2018.10.006_bb0065","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.semarthrit.2011.11.007","article-title":"Treatment of systemic sclerosis-associated calcinosis: a case report of rituximab- induced regression of CREST-related calcinosis and review of the literature","volume":"41","author":"Daoussis","year":"2012","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.autrev.2018.10.006_bb0070","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1002\/art.38098","article-title":"2013 classification criteria for systemic sclerosis: an American College of Rheumatology\/European League against Rheumatism collaborative initiative","volume":"65","author":"Van den Hoogen","year":"2013","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.autrev.2018.10.006_bb0080","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1002\/acr.22434","article-title":"Validations of a novel radiographic scoring system for calcinosis affecting the hands of patients with systemic sclerosis","volume":"67","author":"Chung","year":"2015","journal-title":"Arthritis Care Res"},{"key":"10.1016\/j.autrev.2018.10.006_bb0085","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1001\/jama.2015.3656","article-title":"PRISMA-IPD Development Group. Preferred Reporting items for Systematic Review and Meta-analyses of individual participant data: the PRISMA-IPD Statement","volume":"313","author":"Stewart","year":"2015","journal-title":"JAMA"},{"key":"10.1016\/j.autrev.2018.10.006_bb0090","first-page":"2016","article-title":"Is rituximab an effective treatment of refractory calcinosis?","volume":"31","author":"Dubos","year":"2016","journal-title":"BMJ Case Rep"},{"key":"10.1016\/j.autrev.2018.10.006_bb0095","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/jcpt.12340","article-title":"Systemic sclerosis and calcinosis cutis: response to rituximab","volume":"41","author":"Poormoghim","year":"2016","journal-title":"J Clin Pharm Ther"},{"key":"10.1016\/j.autrev.2018.10.006_bb0100","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.autrev.2015.07.008","article-title":"Rituximab in the treatment of patients with systemic sclerosis. Our experience and review of the literature","volume":"14","author":"Giuggioli","year":"2015","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.autrev.2018.10.006_bb0105","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1016\/j.semarthrit.2014.04.007","article-title":"Flare of calcinosis despite rituximab therapy","volume":"44","author":"Hurabielle","year":"2014","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.autrev.2018.10.006_bb0110","doi-asserted-by":"crossref","first-page":"132","DOI":"10.5144\/1658-3876.2011.132","article-title":"Small lymphocytic lymphoma in a patient with CREST syndrome","volume":"4","author":"William","year":"2011","journal-title":"Hematol Oncol Stem Cell Ther"},{"key":"10.1016\/j.autrev.2018.10.006_bb0115","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/s10006-006-0673-5","article-title":"Solitary extramedullary plasmacytoma and granulomatous sialadenitis of the parotid gland preceding a B-cell non-Hodgkin's lymphoma","volume":"10","author":"Gouveris","year":"2006","journal-title":"Mund Kiefer Gesichtschir"},{"key":"10.1016\/j.autrev.2018.10.006_bb0120","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1067\/mpd.2001.112473","article-title":"New insight into calcinosis of juvenile dermatomyositis: a study of composition and treatment","volume":"138","author":"Mukamel","year":"2001","journal-title":"J Pediatr"},{"key":"10.1016\/j.autrev.2018.10.006_bb0125","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1186\/s13075-014-0480-6","article-title":"Potential role of the lectin pathway of complement in the pathogenesis and disease manifestations of systemic sclerosis: a case inverted question mark control and cohort study","volume":"16","author":"Osthoff","year":"2014","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.autrev.2018.10.006_bb0130","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.autrev.2017.12.010","article-title":"Efficacy and safety of rituximab in systemic sclerosis: French retrospective study and literature review","volume":"17","author":"Thiebaut","year":"2018","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.autrev.2018.10.006_bb0135","first-page":"158","article-title":"Systemic sclerosis related calcinosis: patients provide what specialists want to learn","volume":"167","author":"Christensen","year":"2015","journal-title":"J La State Med Soc"}],"container-title":["Autoimmunity Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156899721930014X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156899721930014X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T21:13:50Z","timestamp":1761599630000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156899721930014X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["S156899721930014X"],"URL":"https:\/\/doi.org\/10.1016\/j.autrev.2018.10.006","relation":{},"ISSN":["1568-9972"],"issn-type":[{"value":"1568-9972","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effectiveness and safety of rituximab for the treatment of refractory systemic sclerosis associated calcinosis: A case series and systematic review of the literature","name":"articletitle","label":"Article Title"},{"value":"Autoimmunity Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.autrev.2018.10.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}