{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T03:37:40Z","timestamp":1764905860567,"version":"3.37.3"},"reference-count":18,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002803","name":"Fondazione CARIPLO","doi-asserted-by":"publisher","award":["2011-0504"],"award-info":[{"award-number":["2011-0504"]}],"id":[{"id":"10.13039\/501100002803","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fondazione UBI","award":["18\/7\/2017"],"award-info":[{"award-number":["18\/7\/2017"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Autoimmunity Reviews"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.autrev.2019.102357","type":"journal-article","created":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T19:41:14Z","timestamp":1563306074000},"page":"102357","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["The vermiform appendix in Parkinson's disease: At the crossroad of peripheral immunity, the nervous system and the intestinal microbiome"],"prefix":"10.1016","volume":"18","author":[{"given":"Marco","family":"Cosentino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristoforo","family":"Comi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franca","family":"Marino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.autrev.2019.102357_bb0005","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1002\/mds.25779","article-title":"Alpha-synuclein in the appendiceal mucosa of neurologically intact subjects","volume":"29","author":"Gray","year":"2014","journal-title":"Mov Disord"},{"key":"10.1016\/j.autrev.2019.102357_bb0010","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1002\/mds.26311","article-title":"Appendectomy may delay Parkinson's disease onset","volume":"30","author":"Mendes","year":"2015","journal-title":"Mov Disord"},{"key":"10.1016\/j.autrev.2019.102357_bb0015","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1002\/mds.26670","article-title":"Appendectomy in mid and later life and risk of Parkinson's disease: a population-based study","volume":"31","author":"Marras","year":"2016","journal-title":"Mov Disord"},{"key":"10.1016\/j.autrev.2019.102357_bb0020","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1002\/mds.26761","article-title":"Appendectomy and risk of Parkinson's disease: a nationwide cohort study with more than 10 years of follow-up","volume":"31","author":"Svensson","year":"2016","journal-title":"Mov Disord"},{"key":"10.1016\/j.autrev.2019.102357_bb0025","first-page":"347","article-title":"Appendectomy history is not related to Parkinson's disease","volume":"7","author":"Yilmaz","year":"2017","journal-title":"J Park Dis"},{"key":"10.1016\/j.autrev.2019.102357_bb0030","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aar5280","article-title":"The vermiform appendix impacts the risk of developing Parkinson's disease","volume":"10","author":"Killinger","year":"2018","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.autrev.2019.102357_bb0035","article-title":"The appendix and the risk of Parkinson's disease: appended notes on correlation and causation","author":"Kim","year":"2018","journal-title":"Mov Disord"},{"key":"10.1016\/j.autrev.2019.102357_bb0040","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.smim.2018.02.005","article-title":"The immunological functions of the appendix: an example of redundancy?","volume":"36","author":"Girard-Madoux","year":"2018","journal-title":"Semin Immunol"},{"key":"10.1016\/j.autrev.2019.102357_bb0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/cei.12821","article-title":"Te Velde AA. The immunology of the vermiform appendix: a review of the literature","volume":"186","author":"Kooij","year":"2016","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.autrev.2019.102357_bb0050","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.autrev.2016.07.022","article-title":"Parkinson's disease: autoimmunity and neuroinflammation","volume":"15","author":"De Virgilio","year":"2016","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.autrev.2019.102357_bb0055","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nature22815","article-title":"T cells from patients with Parkinson's disease recognize \u03b1-synuclein peptides","volume":"546","author":"Sulzer","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.autrev.2019.102357_bb0060","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.3748\/wjg.v17.i19.2437","article-title":"Effects of appendectomy and oral tolerance on dextran sulfate sodium colitis","volume":"17","author":"Yue","year":"2011","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.autrev.2019.102357_bb0065","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1365-2249.2005.02957.x","article-title":"Different cytokine profiles in patients with a history of gangrenous or phlegmonous appendicitis","volume":"143","author":"Rub\u00e9r","year":"2006","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.autrev.2019.102357_bb0070","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/s12974-018-1248-8","article-title":"Parkinson's disease patients have a complex phenotypic and functional Th1 bias: cross-sectional studies of CD4+ Th1\/Th2\/T17 and Treg in drug-na\u00efve and drug-treated patients","volume":"15","author":"Kustrimovic","year":"2018","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.autrev.2019.102357_bb0075","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/mds.26069","article-title":"Gut microbiota are related to Parkinson's disease and clinical phenotype","volume":"30","author":"Scheperjans","year":"2015","journal-title":"Mov Disord"},{"key":"10.1016\/j.autrev.2019.102357_bb0080","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/nrneurol.2015.197","article-title":"Pathogenesis of Parkinson disease--the gut-brain axis and environmental factors","volume":"11","author":"Klingelhoefer","year":"2015","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.autrev.2019.102357_bb0085","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S1474-4422(17)30276-4","article-title":"T cells and Parkinson's disease","volume":"16","author":"Mosley","year":"2017","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.autrev.2019.102357_bb0090","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1258\/jrsm.2010.10k057","article-title":"John and James Parkinson's first description of acute appendicitis and its associated complications of perforation and death","volume":"104","author":"Ramachandran","year":"2011","journal-title":"J R Soc Med"}],"container-title":["Autoimmunity Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568997219301570?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568997219301570?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T00:37:48Z","timestamp":1569199068000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568997219301570"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":18,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["S1568997219301570"],"URL":"https:\/\/doi.org\/10.1016\/j.autrev.2019.102357","relation":{},"ISSN":["1568-9972"],"issn-type":[{"type":"print","value":"1568-9972"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The vermiform appendix in Parkinson's disease: At the crossroad of peripheral immunity, the nervous system and the intestinal microbiome","name":"articletitle","label":"Article Title"},{"value":"Autoimmunity Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.autrev.2019.102357","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102357"}}