{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T09:10:01Z","timestamp":1792401001467,"version":"4.4.0"},"reference-count":132,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009148","name":"Queen Mary University of London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009148","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["36661"],"award-info":[{"award-number":["36661"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-18-CE14-0042"],"award-info":[{"award-number":["ANR-18-CE14-0042"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Autoimmunity Reviews"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.autrev.2021.102758","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T22:30:44Z","timestamp":1611009044000},"page":"102758","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":155,"title":["Novel insights into macrophage diversity in rheumatoid arthritis synovium"],"prefix":"10.1016","volume":"20","author":[{"given":"Marie-Astrid","family":"Boutet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Courties","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Nerviani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Le Goff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Apparailly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costantino","family":"Pitzalis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Blanchard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.autrev.2021.102758_bb0005","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1136\/annrheumdis-2019-215920","article-title":"Global, regional and national burden of rheumatoid arthritis 1990\u20132017: a systematic analysis of the Global Burden of Disease study 2017","volume":"78","author":"Safiri","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2021.102758_bb0010","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1097\/BOR.0b013e32835fd8eb","article-title":"New learnings on the pathophysiology of RA from synovial biopsies","volume":"25","author":"Pitzalis","year":"2013","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.autrev.2021.102758_bb0015","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3389\/fmed.2020.00021","article-title":"New developments in transcriptomic analysis of synovial tissue","volume":"7","author":"Carr","year":"2020","journal-title":"Front Med"},{"key":"10.1016\/j.autrev.2021.102758_bb0020","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3389\/fgene.2019.00317","article-title":"Single-cell RNA-Seq technologies and related computational data analysis","volume":"10","author":"Chen","year":"2019","journal-title":"Front Genet"},{"key":"10.1016\/j.autrev.2021.102758_bb0025","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1038\/s41590-019-0378-1","article-title":"Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry","volume":"20","author":"Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA\/SLE) Consortium","year":"2019","journal-title":"Nat Immunol"},{"key":"10.1016\/j.autrev.2021.102758_bb0030","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1136\/annrheumdis-2013-204603","article-title":"Ultrasound-guided synovial biopsy: a safe, well-tolerated and reliable technique for obtaining high-quality synovial tissue from both large and small joints in early arthritis patients","volume":"74","author":"Kelly","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2021.102758_bb0035","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/s13075-018-1631-y","article-title":"Methods for high-dimensional analysis of cells dissociated from cryopreserved synovial tissue","volume":"20","author":"Accelerating Medicines Partnership RA\/SLE Network","year":"2018","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.autrev.2021.102758_bb0040","doi-asserted-by":"crossref","first-page":"281","DOI":"10.2174\/1568010054022024","article-title":"Macrophages in inflammation","volume":"4","author":"Fujiwara","year":"2005","journal-title":"CDTIA"},{"key":"10.1016\/j.autrev.2021.102758_bb0045","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/nrrheum.2016.91","article-title":"Macrophage heterogeneity in the context of rheumatoid arthritis","volume":"12","author":"Udalova","year":"2016","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.autrev.2021.102758_bb0050","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.it.2004.09.015","article-title":"The chemokine system in diverse forms of macrophage activation and polarization","volume":"25","author":"Mantovani","year":"2004","journal-title":"Trends Immunol"},{"key":"10.1016\/j.autrev.2021.102758_bb0055","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.0105-2896.2009.00859.x","article-title":"Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis","volume":"233","author":"Bartok","year":"2010","journal-title":"Immunol Rev"},{"key":"10.1016\/j.autrev.2021.102758_bb0060","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2017-000527","article-title":"Synovial tissue macrophages: friend or foe?","volume":"3","author":"Kurowska-Stolarska","year":"2017","journal-title":"RMD Open"},{"key":"10.1016\/j.autrev.2021.102758_bb0065","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/s41586-019-1471-1","article-title":"Locally renewing resident synovial macrophages provide a protective barrier for the joint","volume":"572","author":"Culemann","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.autrev.2021.102758_bb0070","doi-asserted-by":"crossref","DOI":"10.1038\/s41591-020-0939-8","article-title":"Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis","author":"Alivernini","year":"2020","journal-title":"Nat Med"},{"key":"10.1016\/j.autrev.2021.102758_bb0075","doi-asserted-by":"crossref","first-page":"18001","DOI":"10.1038\/nrdp.2018.1","article-title":"Rheumatoid arthritis","volume":"4","author":"Smolen","year":"2018","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.autrev.2021.102758_bb0080","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/art.38273","article-title":"Features of the synovium of individuals at risk of developing rheumatoid arthritis: implications for understanding preclinical rheumatoid arthritis: synovium features in RA-associated systemic autoimmunity","volume":"66","author":"de Hair","year":"2014","journal-title":"Arthrit Rheumatol"},{"key":"10.1016\/j.autrev.2021.102758_bb0085","doi-asserted-by":"crossref","first-page":"107","DOI":"10.2174\/1874312901105010107","article-title":"The synovium in rheumatoid arthritis","volume":"5","author":"Hitchon","year":"2011","journal-title":"TORJ"},{"key":"10.1016\/j.autrev.2021.102758_bb0090","doi-asserted-by":"crossref","DOI":"10.1136\/annrheumdis-2019-216655","article-title":"EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2019 update","author":"Smolen","year":"2020","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2021.102758_bb0095","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.2174\/1381612821666150310145758","article-title":"Towards a stratified targeted approach with biologic treatments in rheumatoid arthritis: role of synovial pathobiology","volume":"21","author":"Astorri","year":"2015","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.autrev.2021.102758_bb0100","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/j.1365-2559.2006.02508.x","article-title":"Synovitis score: discrimination between chronic low-grade and high-grade synovitis","volume":"49","author":"Krenn","year":"2006","journal-title":"Histopathology"},{"key":"10.1016\/j.autrev.2021.102758_bb0105","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jbspin.2018.04.004","article-title":"IMSYC immunologic synovitis score: a new score for synovial membrane characterization in inflammatory and non-inflammatory arthritis","volume":"86","author":"Najm","year":"2019","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.autrev.2021.102758_bb0110","doi-asserted-by":"crossref","first-page":"R90","DOI":"10.1186\/ar4555","article-title":"Synovial phenotypes in rheumatoid arthritis correlate with response to biologic therapeutics","volume":"16","author":"Dennis","year":"2014","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.autrev.2021.102758_bb0115","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1136\/annrheumdis-2018-214539","article-title":"Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients","volume":"78","author":"Humby","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2021.102758_bb0120","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2016.00430","article-title":"Ectopic lymphoid structures: powerhouse of autoimmunity","volume":"7","author":"Corsiero","year":"2016","journal-title":"Front Immunol"},{"key":"10.1016\/j.autrev.2021.102758_bb0125","series-title":"Tertiary lymphoid organs in rheumatoid arthritis","author":"Rivellese","year":"2020"},{"key":"10.1016\/j.autrev.2021.102758_bb0130","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1002\/art.40428","article-title":"Identification of three rheumatoid arthritis disease subtypes by machine learning integration of synovial histologic features and RNA sequencing data","volume":"70","author":"Orange","year":"2018","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.autrev.2021.102758_bb0135","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1016\/j.celrep.2019.07.091","article-title":"Molecular portraits of early rheumatoid arthritis identify clinical and treatment response phenotypes","volume":"28","author":"Lewis","year":"2019","journal-title":"Cell Rep"},{"key":"10.1016\/j.autrev.2021.102758_bb0140","doi-asserted-by":"crossref","first-page":"8448","DOI":"10.1038\/s41598-019-44895-9","article-title":"General synovitis score and immunologic synovitis score reflect clinical disease activity in patients with advanced stage rheumatoid arthritis","volume":"9","author":"Schmidt","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.autrev.2021.102758_bb0145","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1136\/annrheumdis-2019-215751","volume":"78","author":"Lliso-Ribera","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2021.102758_bb0150","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1002\/art.40218","article-title":"Synovial immunophenotype and anti-citrullinated peptide antibodies in rheumatoid arthritis patients: relationship to treatment response and radiologic prognosis","volume":"69","author":"Orr","year":"2017","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.autrev.2021.102758_bb0155","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1002\/art.41184","article-title":"B cell synovitis and clinical phenotypes in rheumatoid Arthritis: relationship to disease stages and drug exposure","volume":"72","author":"Rivellese","year":"2020","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.autrev.2021.102758_bb0160","doi-asserted-by":"crossref","first-page":"845","DOI":"10.3389\/fimmu.2020.00845","article-title":"A pauci-immune synovial pathotype predicts inadequate response to TNF\u03b1-blockade in rheumatoid arthritis patients","volume":"11","author":"Nerviani","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.autrev.2021.102758_bb0165","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0197001","article-title":"Association between IL-6 production in synovial explants from rheumatoid arthritis patients and clinical and imaging response to biologic treatment: a pilot study","volume":"13","author":"Andersen","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.autrev.2021.102758_bb0170","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1136\/annrheumdis-2016-210424","article-title":"Synovial features of patients with rheumatoid arthritis and psoriatic arthritis in clinical and ultrasound remission differ under anti-TNF therapy: a clue to interpret different chances of relapse after clinical remission?","volume":"76","author":"Alivernini","year":"2017","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2021.102758_bb0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/00365513.2011.626868","article-title":"Soluble CD163","volume":"72","author":"M\u00f8ller","year":"2012","journal-title":"Scand J Clin Lab Invest"},{"key":"10.1016\/j.autrev.2021.102758_bb0180","first-page":"498","article-title":"Macrophage activity assessed by soluble CD163 in early rheumatoid arthritis: association with disease activity but different response patterns to synthetic and biologic DMARDs","volume":"33","author":"Greisen","year":"2015","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.autrev.2021.102758_bb0185","article-title":"Apoptosis inhibitor of macrophage\/CD5L is associated with disease activity in rheumatoid arthritis","author":"Wu","year":"2020","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.autrev.2021.102758_bb0190","doi-asserted-by":"crossref","DOI":"10.1172\/JCI126866","article-title":"Dynamic transcriptome analysis unveils key pro-resolving factors of chronic inflammatory arthritis","author":"Kong","year":"2020","journal-title":"J Clin Investig"},{"key":"10.1016\/j.autrev.2021.102758_bb0195","doi-asserted-by":"crossref","first-page":"R86","DOI":"10.1186\/ar3013","article-title":"Plasma and synovial fluid microRNAs as potential biomarkers of rheumatoid arthritis and osteoarthritis","volume":"12","author":"Murata","year":"2010","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.autrev.2021.102758_bb0200","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/art.30651","article-title":"What do microRNAs mean for rheumatoid arthritis?","volume":"64","author":"Duroux-Richard","year":"2012","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.autrev.2021.102758_bb0205","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s13075-016-1023-0","article-title":"MicroRNA-125b: association with disease activity and the treatment response of patients with early rheumatoid arthritis","volume":"18","author":"Hruskova","year":"2016","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.autrev.2021.102758_bb0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/342524","article-title":"Circulating miRNA-125b is a potential biomarker predicting response to rituximab in rheumatoid arthritis","volume":"2014","author":"Duroux-Richard","year":"2014","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.autrev.2021.102758_bb0215","series-title":"Advances in immunology","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/bs.ai.2019.08.006","article-title":"Origin and function of synovial macrophage subsets during inflammatory joint disease","volume":"vol. 143","author":"Culemann","year":"2019"},{"key":"10.1016\/j.autrev.2021.102758_bb0220","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.smim.2016.03.017","article-title":"Development and function of tissue resident macrophages in mice","volume":"27","author":"Kierdorf","year":"2015","journal-title":"Semin Immunol"},{"key":"10.1016\/j.autrev.2021.102758_bb0225","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.cell.2019.02.028","article-title":"Resident macrophages cloak tissue microlesions to prevent neutrophil-driven inflammatory damage","volume":"177","author":"Uderhardt","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.autrev.2021.102758_bb0230","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.3389\/fimmu.2019.01146","article-title":"Ontogeny of synovial macrophages and the roles of synovial macrophages from different origins in arthritis","volume":"10","author":"Tu","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.autrev.2021.102758_bb0235","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.celrep.2014.09.032","article-title":"Nonclassical Ly6C(\u2212) monocytes drive the development of inflammatory arthritis in mice","volume":"9","author":"Misharin","year":"2014","journal-title":"Cell Rep"},{"key":"10.1016\/j.autrev.2021.102758_bb0240","doi-asserted-by":"crossref","first-page":"5972","DOI":"10.7150\/thno.29313","article-title":"Delivery of miR-146a to Ly6C high monocytes inhibits pathogenic bone erosion in inflammatory arthritis","volume":"8","author":"Ammari","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.autrev.2021.102758_bb0245","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0007865","article-title":"Monocyte scintigraphy in rheumatoid arthritis: the dynamics of monocyte migration in immune-mediated inflammatory disease","volume":"4","author":"Thurlings","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.autrev.2021.102758_bb0250","doi-asserted-by":"crossref","DOI":"10.1126\/science.aah4573","article-title":"Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors","volume":"356","author":"Villani","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.autrev.2021.102758_bb0255","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/s41580-020-0232-1","article-title":"The clearance of dead cells by efferocytosis","volume":"21","author":"Boada-Romero","year":"2020","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.autrev.2021.102758_bb0260","first-page":"3508","article-title":"Efficient clearance of early apoptotic cells by human macrophages requires M2c polarization and MerTK induction","volume":"189","author":"Zizzo","year":"2012","journal-title":"JI"},{"key":"10.1016\/j.autrev.2021.102758_bb0265","doi-asserted-by":"crossref","first-page":"1614627","DOI":"10.1155\/2020\/1614627","article-title":"New insights into the role of Tyro3, Axl, and Mer receptors in rheumatoid arthritis","volume":"2020","author":"Pagani","year":"2020","journal-title":"Dis Markers"},{"key":"10.1016\/j.autrev.2021.102758_bb0270","doi-asserted-by":"crossref","first-page":"742","DOI":"10.3389\/fimmu.2018.00742","article-title":"Protective role of the MER tyrosine kinase via efferocytosis in rheumatoid arthritis models","volume":"9","author":"Waterborg","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.autrev.2021.102758_bb0275","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.3389\/fimmu.2018.02586","article-title":"Factors produced by macrophages eliminating apoptotic cells demonstrate pro-resolutive properties and terminate ongoing inflammation","volume":"9","author":"Bonnefoy","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.autrev.2021.102758_bb0280","doi-asserted-by":"crossref","first-page":"7907","DOI":"10.1038\/s41598-020-64431-4","article-title":"Synovial tissue transcriptomes of long-standing rheumatoid arthritis are dominated by activated macrophages that reflect microbial stimulation","volume":"10","author":"Smiljanovic","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.autrev.2021.102758_bb0285","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2147\/ITT.S243636","article-title":"Role of chemokines and chemokine receptors in rheumatoid arthritis","volume":"9","author":"Elemam","year":"2020","journal-title":"Immunotargets Ther"},{"key":"10.1016\/j.autrev.2021.102758_bb0290","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/2045-824X-5-11","article-title":"Macrophages and angiogenesis in rheumatic diseases","volume":"5","author":"Maruotti","year":"2013","journal-title":"Vasc Cell"},{"key":"10.1016\/j.autrev.2021.102758_bb0295","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s41232-019-0111-3","article-title":"RANKL biology: bone metabolism, the immune system, and beyond","volume":"40","author":"Ono","year":"2020","journal-title":"Inflamm Regener"},{"key":"10.1016\/j.autrev.2021.102758_bb0300","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.216267","article-title":"Common signalling pathways in macrophage and osteoclast multinucleation","volume":"131","author":"Pereira","year":"2018","journal-title":"J Cell Sci"},{"key":"10.1016\/j.autrev.2021.102758_bb0305","article-title":"Classical macrophage activation up-regulates several matrix metalloproteinases through mitogen activated protein kinases and nuclear factor-\u03baB","volume":"7","author":"Huang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.autrev.2021.102758_bb0310","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/4895050","article-title":"A tale of two joints: the role of matrix metalloproteases in cartilage biology","volume":"2016","author":"Rose","year":"2016","journal-title":"Dis Markers"},{"key":"10.1016\/j.autrev.2021.102758_bb0315","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1002\/art.40453","article-title":"Transcriptional profiling of synovial macrophages using minimally invasive ultrasound-guided synovial biopsies in rheumatoid arthritis","volume":"70","author":"Mandelin","year":"2018","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.autrev.2021.102758_bb0320","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/s41467-017-02659-x","article-title":"Single-cell RNA-seq of rheumatoid arthritis synovial tissue using low-cost microfluidic instrumentation","volume":"9","author":"Stephenson","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.autrev.2021.102758_bb0325","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aau8587","article-title":"HBEGF+ macrophages in rheumatoid arthritis induce fibroblast invasiveness","volume":"11","author":"Kuo","year":"2019","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.autrev.2021.102758_bb0330","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1038\/s41590-019-0526-7","article-title":"Identification of a novel arthritis-associated osteoclast precursor macrophage regulated by FoxM1","volume":"20","author":"Hasegawa","year":"2019","journal-title":"Nat Immunol"},{"key":"10.1016\/j.autrev.2021.102758_bb0335","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/s41467-018-02892-y","article-title":"Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis","volume":"9","author":"Mizoguchi","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.autrev.2021.102758_bb0340","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/s41586-020-2222-z","article-title":"Notch signalling drives synovial fibroblast identity and arthritis pathology","volume":"582","author":"Accelerating Medicines Partnership Rheumatoid Arthritis & Systemic Lupus Erythematosus (AMP RA\/SLE) Consortium","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.autrev.2021.102758_bb0345","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/s41586-019-1263-7","article-title":"Distinct fibroblast subsets drive inflammation and damage in arthritis","volume":"570","author":"Croft","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.autrev.2021.102758_bb0350","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1002\/art.20811","article-title":"Fibroblast-like synoviocytes derived from patients with rheumatoid arthritis show the imprint of synovial tissue heterogeneity: evidence of a link between an increased myofibroblast-like phenotype and high-inflammation synovitis","volume":"52","author":"Kasperkovitz","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.autrev.2021.102758_bb0355","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1002\/JLB.5RU0519-145R","article-title":"JAK inhibition by methotrexate (and csDMARDs) may explain clinical efficacy as monotherapy and combination therapy","volume":"106","author":"Gremese","year":"2019","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.autrev.2021.102758_bb0360","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1136\/annrheumdis-2017-212537","article-title":"Methotrexate limits inflammation through an A20-dependent cross-tolerance mechanism","volume":"77","author":"Municio","year":"2018","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2021.102758_bb0365","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.3390\/ijms19102894","article-title":"Inhibitory effect of methotrexate on rheumatoid arthritis inflammation and comprehensive metabolomics analysis using ultra-performance liquid chromatography-quadrupole time of flight-mass spectrometry (UPLC-Q\/TOF-MS)","volume":"19","author":"Pang","year":"2018","journal-title":"IJMS"},{"key":"10.1016\/j.autrev.2021.102758_bb0370","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s13075-017-1325-x","article-title":"In-vivo monitoring of anti-folate therapy in arthritic rats using [18F]fluoro-PEG-folate and positron emission tomography","volume":"19","author":"Chandrupatla","year":"2017","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.autrev.2021.102758_bb0375","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/8092781","article-title":"Imaging and methotrexate response monitoring of systemic inflammation in arthritic rats employing the macrophage PET tracer[18F]Fluoro-PEG-folate","volume":"2018","author":"Chandrupatla","year":"2018","journal-title":"Contrast Media Mol Imaging"},{"key":"10.1016\/j.autrev.2021.102758_bb0380","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1046\/j.1365-2567.2001.01272.x","article-title":"Sulphasalazine inhibits macrophage activation: inhibitory effects on inducible nitric oxide synthase expression, interleukin-12 production and major histocompatibility complex II expression","volume":"103","author":"Hasko","year":"2001","journal-title":"Immunology"},{"key":"10.1016\/j.autrev.2021.102758_bb0385","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1046\/j.1365-2567.1999.00849.x","article-title":"Sulfasalazine prevents T-helper 1 immune response by suppressing interleukin-12 production in macrophages","volume":"98","author":"Kang","year":"1999","journal-title":"Immunology"},{"key":"10.1016\/j.autrev.2021.102758_bb0390","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1002\/1529-0131(200009)43:9<1941::AID-ANR4>3.0.CO;2-O","article-title":"The antiinflammatory drug sulfasalazine inhibits tumor necrosis factor alpha expression in macrophages by inducing apoptosis","volume":"43","author":"Rodenburg","year":"2000","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.autrev.2021.102758_bb0395","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1136\/ard.2005.045641","article-title":"Anti-inflammatory effects of leflunomide in combination with methotrexate on co-culture of T lymphocytes and synovial macrophages from rheumatoid arthritis patients","volume":"65","author":"Cutolo","year":"2006","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2021.102758_bb0400","doi-asserted-by":"crossref","first-page":"241","DOI":"10.3390\/metabo10060241","article-title":"Changes in plasma itaconate elevation in early rheumatoid arthritis patients elucidates disease activity associated macrophage activation","volume":"10","author":"Daly","year":"2020","journal-title":"Metabolites"},{"key":"10.1016\/j.autrev.2021.102758_bb0405","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.3389\/fimmu.2019.01591","article-title":"Glucocorticoids shape macrophage phenotype for tissue repair","volume":"10","author":"Desgeorges","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.autrev.2021.102758_bb0410","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1136\/annrheumdis-2017-212762","article-title":"Glucocorticoid receptor in stromal cells is essential for glucocorticoid-mediated suppression of inflammation in arthritis","volume":"77","author":"Koenen","year":"2018","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2021.102758_bb0415","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1038\/s41590-019-0417-y","article-title":"The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell\u2013mediated resistance to metastasis","volume":"20","author":"Mattiola","year":"2019","journal-title":"Nat Immunol"},{"key":"10.1016\/j.autrev.2021.102758_bb0420","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1530\/JOE-17-0223","article-title":"Macrophage 11\u03b2-HSD-1 deficiency promotes inflammatory angiogenesis","volume":"234","author":"Zhang","year":"2017","journal-title":"J Endocrinol"},{"key":"10.1016\/j.autrev.2021.102758_bb0425","doi-asserted-by":"crossref","first-page":"102398","DOI":"10.1016\/j.autrev.2019.102398","article-title":"Failure of anti-TNF treatment in patients with rheumatoid arthritis: the pros and cons of the early use of alternative biological agents","volume":"18","author":"Rubbert-Roth","year":"2019","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.autrev.2021.102758_bb0430","first-page":"130","article-title":"The role of macrophages in the response to TNF inhibition in experimental arthritis","volume":"200","author":"Huang","year":"2018","journal-title":"JI"},{"key":"10.1016\/j.autrev.2021.102758_bb0435","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3389\/fimmu.2019.00003","article-title":"Polarization of rheumatoid macrophages by TNF targeting through an IL-10\/STAT3 mechanism","volume":"10","author":"Degbo\u00e9","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.autrev.2021.102758_bb0440","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2015-000065","article-title":"Bone and TNF in rheumatoid arthritis: clinical implications","volume":"1","author":"Manara","year":"2015","journal-title":"RMD Open"},{"key":"10.1016\/j.autrev.2021.102758_bb0445","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1172\/JCI11176","article-title":"TNF-\u03b1 induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand","volume":"106","author":"Lam","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1016\/j.autrev.2021.102758_bb0450","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.bone.2017.10.020","article-title":"TNF\u03b1 blockade mediates bone protection in antigen-induced arthritis by reducing osteoclast precursor supply","volume":"107","author":"Uster","year":"2018","journal-title":"Bone"},{"key":"10.1016\/j.autrev.2021.102758_bb0455","first-page":"325","article-title":"Targeted therapies in rheumatoid arthritis: focus on rituximab","volume":"1","author":"Teng","year":"2007","journal-title":"Biologics"},{"key":"10.1016\/j.autrev.2021.102758_bb0460","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1136\/ard.2006.062505","article-title":"Changes in macrophage function after rituximab treatment in patients with rheumatoid arthritis","volume":"66","author":"Toubi","year":"2007","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2021.102758_bb0465","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1136\/annrheumdis-2011-200348","article-title":"Abatacept modulates proinflammatory macrophage responses upon cytokine-activated T cell and Toll-like receptor ligand stimulation","volume":"71","author":"Wenink","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2021.102758_bb0470","doi-asserted-by":"crossref","first-page":"R176","DOI":"10.1186\/ar2865","article-title":"CTLA4-Ig interacts with cultured synovial macrophages from rheumatoid arthritis patients and downregulates cytokine production","volume":"11","author":"Cutolo","year":"2009","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.autrev.2021.102758_bb0475","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13075-018-1527-x","article-title":"Abatacept blocks anti-citrullinated protein antibody and rheumatoid factor mediated cytokine production in human macrophages in IDO-dependent manner","volume":"20","author":"Bozec","year":"2018","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.autrev.2021.102758_bb0480","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2016-000345","article-title":"Baseline autoantibodies preferentially impact abatacept efficacy in patients with rheumatoid arthritis who are biologic na\u00efve: 6-month results from a real-world, international, prospective study","volume":"3","author":"Alten","year":"2017","journal-title":"RMD Open"},{"key":"10.1016\/j.autrev.2021.102758_bb0485","doi-asserted-by":"crossref","DOI":"10.1136\/annrheumdis-2017-212880","article-title":"In vivo visualisation of different modes of action of biological DMARDs inhibiting osteoclastic bone resorption","author":"Matsuura","year":"2018","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2021.102758_bb0490","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ejphar.2016.03.028","article-title":"Modulation of human monocyte\/macrophage activity by tocilizumab, abatacept and etanercept: an in vitro study","volume":"780","author":"Obeng","year":"2016","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.autrev.2021.102758_bb0495","doi-asserted-by":"crossref","first-page":"3856","DOI":"10.1002\/art.37691","article-title":"Regulation of inflammatory responses in tumor necrosis factor-activated and rheumatoid arthritis synovial macrophages by JAK inhibitors","volume":"64","author":"Yarilina","year":"2012","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.autrev.2021.102758_bb0500","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3389\/fimmu.2016.00213","article-title":"K\/BxN serum-transfer arthritis as a model for human inflammatory arthritis","volume":"7","author":"Christensen","year":"2016","journal-title":"Front Immunol"},{"key":"10.1016\/j.autrev.2021.102758_bb0505","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12950-019-0206-2","article-title":"Inhibition of pSTAT1 by tofacitinib accounts for the early improvement of experimental chronic synovitis","volume":"16","author":"P\u00e9rez-Baos","year":"2019","journal-title":"J Inflamm"},{"key":"10.1016\/j.autrev.2021.102758_bb0510","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/exd.14059","article-title":"The Janus Kinase inhibitor tofacitinib impacts human dendritic cell differentiation and favours M1 macrophage development","volume":"29","author":"Stalder","year":"2020","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.autrev.2021.102758_bb0515","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.bbrc.2018.10.083","article-title":"In vivo imaging of activated macrophages by 18F-FEDAC, a TSPO targeting PET ligand, in the use of biologic disease-modifying anti-rheumatic drugs (bDMARDs)","volume":"506","author":"Chung","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.autrev.2021.102758_bb0520","doi-asserted-by":"crossref","first-page":"677","DOI":"10.2217\/imt-2018-0156","article-title":"Re-education of macrophages as a therapeutic strategy in cancer","volume":"11","author":"Kowal","year":"2019","journal-title":"Immunotherapy"},{"key":"10.1016\/j.autrev.2021.102758_bb0525","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.3389\/fimmu.2019.02055","article-title":"GM-CSF-dependent inflammatory pathways","volume":"10","author":"Hamilton","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.autrev.2021.102758_bb0530","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/art.40323","article-title":"A randomized phase IIb study of Mavrilimumab and golimumab in rheumatoid Arthritis","volume":"70","author":"Weinblatt","year":"2018","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.autrev.2021.102758_bb0535","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1002\/art.40420","article-title":"Mavrilimumab, a fully human granulocyte-macrophage colony-stimulating factor receptor \u03b1 monoclonal antibody: long-term safety and efficacy in patients with rheumatoid arthritis","volume":"70","author":"Burmester","year":"2018","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.autrev.2021.102758_bb0540","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1080\/13543784.2019.1631795","article-title":"Mavrilimumab: a unique insight and update on the current status in the treatment of rheumatoid arthritis","volume":"28","author":"Crotti","year":"2019","journal-title":"Expert Opin Investig Drugs"},{"key":"10.1016\/j.autrev.2021.102758_bb0545","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1093\/rheumatology\/kex383","article-title":"Blockade of GM-CSF pathway induced sustained suppression of myeloid and T cell activities in rheumatoid arthritis","volume":"57","author":"Guo","year":"2018","journal-title":"Rheumatology"},{"key":"10.1016\/j.autrev.2021.102758_bb0550","first-page":"73","article-title":"The VICM biomarker is released from activated macrophages and inhibited by anti-GM-CSFR\u03b1-mAb treatment in rheumatoid arthritis patients","volume":"37","author":"Mortensen","year":"2019","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.autrev.2021.102758_bb0555","doi-asserted-by":"crossref","first-page":"852","DOI":"10.3389\/fimmu.2018.00852","article-title":"Extracellular purine metabolism is the switchboard of immunosuppressive macrophages and a novel target to treat diseases with macrophage imbalances","volume":"9","author":"Ohradanova-Repic","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.autrev.2021.102758_bb0560","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s13075-019-1879-x","volume":"21","author":"for the NEXUS Study Group","year":"2019","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.autrev.2021.102758_bb0565","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1093\/rheumatology\/key416","article-title":"Efficacy of denosumab with regard to bone destruction in prognostic subgroups of Japanese rheumatoid arthritis patients from the phase II DRIVE study","volume":"58","author":"Ishiguro","year":"2019","journal-title":"Rheumatology"},{"key":"10.1016\/j.autrev.2021.102758_bb0570","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1136\/annrheumdis-2018-214827","volume":"78","author":"Takeuchi","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2021.102758_bb0575","article-title":"IRAK4 inhibition: a promising strategy for treating RA joint inflammation and bone erosion","author":"Umar","year":"2020","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.autrev.2021.102758_bb0580","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jconrel.2019.04.027","article-title":"Nanomedicines for improved targetability to inflamed synovium for treatment of rheumatoid arthritis: multi-functionalization as an emerging strategy to optimize therapeutic efficacy","volume":"303","author":"Fang","year":"2019","journal-title":"J Control Release"},{"key":"10.1016\/j.autrev.2021.102758_bb0585","doi-asserted-by":"crossref","first-page":"102288","DOI":"10.1016\/j.jaut.2019.05.016","article-title":"Targeting CD34+ cells of the inflamed synovial endothelium by guided nanoparticles for the treatment of rheumatoid arthritis","volume":"103","author":"Colombo","year":"2019","journal-title":"J Autoimmun"},{"key":"10.1016\/j.autrev.2021.102758_bb0590","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1136\/ard.57.7.408","article-title":"Local removal of phagocytic synovial lining cells by clodronate-liposomes decreases cartilage destruction during collagen type II arthritis","volume":"57","author":"Van Lent","year":"1998","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2021.102758_bb0595","doi-asserted-by":"crossref","first-page":"8204","DOI":"10.12659\/MSM.917396","article-title":"Nuclear factor kappa B (NF-\u03baB) targeted self-assembled nanoparticles loaded with methotrexate for treatment of rheumatoid arthritis","volume":"25","author":"Li","year":"2019","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.autrev.2021.102758_bb0600","doi-asserted-by":"crossref","first-page":"24984","DOI":"10.1021\/acsami.9b04979","article-title":"Injectable click-crosslinked hyaluronic acid depot to prolong therapeutic activity in articular joints affected by rheumatoid arthritis","volume":"11","author":"Seo","year":"2019","journal-title":"ACS Appl Mater Interfaces"},{"key":"10.1016\/j.autrev.2021.102758_bb0605","doi-asserted-by":"crossref","first-page":"9113","DOI":"10.2147\/IJN.S219413","article-title":"Co-delivery of prednisolone and curcumin in human serum albumin nanoparticles for effective treatment of rheumatoid arthritis","volume":"14","author":"Yan","year":"2019","journal-title":"IJN"},{"key":"10.1016\/j.autrev.2021.102758_bb0610","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.intimp.2019.04.027","article-title":"Curcumin attenuates collagen-induced rat arthritis via anti-inflammatory and apoptotic effects","volume":"72","author":"Wang","year":"2019","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.autrev.2021.102758_bb0615","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1080\/10717544.2017.1422295","article-title":"Bone-targeted methotrexate\u2013alendronate conjugate inhibits osteoclastogenesis in vitro and prevents bone loss and inflammation of collagen-induced arthritis in vivo","volume":"25","author":"Xie","year":"2018","journal-title":"Drug Deliv"},{"key":"10.1016\/j.autrev.2021.102758_bb0620","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3390\/cells9010111","article-title":"The role of notch signaling in macrophages during inflammation and infection: implication in rheumatoid arthritis?","volume":"9","author":"Keewan","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.autrev.2021.102758_bb0625","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s11095-018-2401-x","article-title":"Notch-1 siRNA and methotrexate towards a multifunctional approach in rhematoid arthritis management: a nanomedicine approach","volume":"35","author":"Zhao","year":"2018","journal-title":"Pharm Res"},{"key":"10.1016\/j.autrev.2021.102758_bb0630","doi-asserted-by":"crossref","first-page":"4698","DOI":"10.1039\/C9BM01025D","article-title":"Nanoparticle-delivered siRNA targeting Bruton\u2019s tyrosine kinase for rheumatoid arthritis therapy","volume":"7","author":"Zhao","year":"2019","journal-title":"Biomater Sci"},{"key":"10.1016\/j.autrev.2021.102758_bb0635","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1002\/art.23660","article-title":"Efficient suppression of murine arthritis by combined anticytokine small interfering RNA lipoplexes","volume":"58","author":"Khoury","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.autrev.2021.102758_bb0640","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1002\/art.21876","article-title":"Efficient new cationic liposome formulation for systemic delivery of small interfering RNA silencing tumor necrosis factor \u03b1 in experimental arthritis","volume":"54","author":"Khoury","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.autrev.2021.102758_bb0645","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1136\/annrheumdis-2012-202403","article-title":"Nicotinamide phosphoribosyltransferase\/visfatin expression by inflammatory monocytes mediates arthritis pathogenesis","volume":"72","author":"Pr\u00e9sumey","year":"2013","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2021.102758_bb0650","doi-asserted-by":"crossref","DOI":"10.1080\/19420862.2019.1685832","article-title":"Harnessing MerTK agonism for targeted therapeutics","volume":"12","author":"Kedage","year":"2020","journal-title":"MAbs"},{"key":"10.1016\/j.autrev.2021.102758_bb0655","first-page":"1069","article-title":"The autoimmune susceptibility gene C5orf30 regulates macrophage-mediated resolution of inflammation","volume":"202","author":"Dorris","year":"2019","journal-title":"JI"},{"key":"10.1016\/j.autrev.2021.102758_bb0660","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1038\/s41592-019-0548-y","article-title":"High-definition spatial transcriptomics for in situ tissue profiling","volume":"16","author":"Vickovic","year":"2019","journal-title":"Nat Methods"}],"container-title":["Autoimmunity Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568997221000173?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568997221000173?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T21:21:42Z","timestamp":1761600102000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568997221000173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":132,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["S1568997221000173"],"URL":"https:\/\/doi.org\/10.1016\/j.autrev.2021.102758","relation":{},"ISSN":["1568-9972"],"issn-type":[{"value":"1568-9972","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel insights into macrophage diversity in rheumatoid arthritis synovium","name":"articletitle","label":"Article Title"},{"value":"Autoimmunity Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.autrev.2021.102758","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102758"}}