{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:13:43Z","timestamp":1793726023931,"version":"4.6.1"},"reference-count":138,"publisher":"Elsevier BV","issue":"7-8","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"am","delay-in-days":414,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK124408"],"award-info":[{"award-number":["R01 DK124408"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011684","name":"Crohn's & Colitis Foundation of America","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011684","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001063","name":"Crohn's and Colitis Foundation of America","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005615","name":"Beth Israel Deaconess Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005615","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031230","name":"Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Autoimmunity Reviews"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.autrev.2024.103591","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T12:42:32Z","timestamp":1722948152000},"page":"103591","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["B and T cells: (Still) the dominant orchestrators in autoimmune hepatitis"],"prefix":"10.1016","volume":"23","author":[{"given":"Maria Serena","family":"Longhi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgina","family":"Mieli-Vergani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Vergani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.autrev.2024.103591_bb0005","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1002\/hep.1840180435","article-title":"Meeting report: international autoimmune hepatitis group","volume":"18","author":"Johnson","year":"1993","journal-title":"Hepatology"},{"key":"10.1016\/j.autrev.2024.103591_bb0010","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1172\/JCI113949","article-title":"Major antigen of liver kidney microsomal autoantibodies in idiopathic autoimmune hepatitis is cytochrome P450db1","volume":"83","author":"Manns","year":"1989","journal-title":"J Clin Invest"},{"key":"10.1016\/j.autrev.2024.103591_bb0015","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/j.1572-0241.2002.05479.x","article-title":"Antibodies to soluble liver antigen\/liver pancreas and HLA risk factors for type 1 autoimmune hepatitis","volume":"97","author":"Czaja","year":"2002","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.autrev.2024.103591_bb0020","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1080\/0891693021000054101","article-title":"Frequency and significance of antibodies to soluble liver antigen\/liver pancreas in variant autoimmune hepatitis","volume":"35","author":"Czaja","year":"2002","journal-title":"Autoimmunity"},{"key":"10.1016\/j.autrev.2024.103591_bb0025","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S0016-5085(99)70186-1","article-title":"Formiminotransferase cyclodeaminase is an organ-specific autoantigen recognized by sera of patients with autoimmune hepatitis","volume":"116","author":"Lapierre","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1016\/j.autrev.2024.103591_bb0030","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1055\/s-2002-35702","article-title":"Definition and classification of autoimmune hepatitis","volume":"22","author":"McFarlane","year":"2002","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.autrev.2024.103591_bb0035","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/hep.510250308","article-title":"Autoimmune hepatitis in childhood: a 20-year experience","volume":"25","author":"Gregorio","year":"1997","journal-title":"Hepatology"},{"key":"10.1016\/j.autrev.2024.103591_bb0040","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0168-8278(00)80271-8","article-title":"Mycophenolate mofetil for maintenance of remission in autoimmune hepatitis in patients resistant to or intolerant of azathioprine","volume":"33","author":"Richardson","year":"2000","journal-title":"J Hepatol"},{"key":"10.1016\/j.autrev.2024.103591_bb0045","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jhep.2009.02.024","article-title":"Mycophenolate mofetil as rescue treatment for autoimmune liver disease in children: a 5-year follow-up","volume":"51","author":"Aw","year":"2009","journal-title":"J Hepatol"},{"key":"10.1016\/j.autrev.2024.103591_bb0050","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0168-8278(99)80297-9","article-title":"International autoimmune hepatitis group report: review of criteria for diagnosis of autoimmune hepatitis","volume":"31","author":"Alvarez","year":"1999","journal-title":"J Hepatol"},{"key":"10.1016\/j.autrev.2024.103591_bb0055","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1097\/01.mpg.0000235975.75120.38","article-title":"Follow-up of children with autoimmune hepatitis treated with cyclosporine","volume":"43","author":"Cuarterolo","year":"2006","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.autrev.2024.103591_bb0060","first-page":"771","article-title":"Tacrolimus: a potential new treatment for autoimmune chronic active hepatitis: results of an open-label preliminary trial","volume":"90","author":"Van Thiel","year":"1995","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.autrev.2024.103591_bb0065","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1002\/hep.31893","article-title":"Human leukocyte antigen profile predicts severity of autoimmune liver disease in children of European ancestry","volume":"74","author":"Ma","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.autrev.2024.103591_bb0070","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.jhep.2006.07.034","article-title":"HLA class II influences humoral autoimmunity in patients with type 2 autoimmune hepatitis","volume":"45","author":"Djilali-Saiah","year":"2006","journal-title":"J Hepatol"},{"key":"10.1016\/j.autrev.2024.103591_bb0075","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/hep.510250211","article-title":"Associations between alleles of the major histocompatibility complex and type 1 autoimmune hepatitis","volume":"25","author":"Czaja","year":"1997","journal-title":"Hepatology"},{"key":"10.1016\/j.autrev.2024.103591_bb0080","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/0016-5085(93)90157-8","article-title":"Significance of HLA DR4 in type 1 autoimmune hepatitis","volume":"105","author":"Czaja","year":"1993","journal-title":"Gastroenterology"},{"key":"10.1016\/j.autrev.2024.103591_bb0085","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1053\/j.gastro.2014.04.022","article-title":"Genome-wide association study identifies variants associated with autoimmune hepatitis type 1","volume":"147","author":"de Boer","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.autrev.2024.103591_bb0090","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/hep.32417","article-title":"Genome-wide meta-analysis identifies susceptibility loci for autoimmune hepatitis type 1","volume":"76","author":"Li","year":"2022","journal-title":"Hepatology"},{"key":"10.1016\/j.autrev.2024.103591_bb0095","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1126\/science.aar7201","article-title":"Translocation of a gut pathobiont drives autoimmunity in mice and humans","volume":"359","author":"Manfredo Vieira","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.autrev.2024.103591_bb0100","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.chom.2022.05.006","article-title":"Tet2 deficiency drives liver microbiome dysbiosis triggering Tc1 cell autoimmune hepatitis","volume":"30","author":"Pandey","year":"2022","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.autrev.2024.103591_bb0105","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1053\/j.gastro.2005.12.020","article-title":"Polyclonal T-cell responses to cytochrome P450IID6 are associated with disease activity in autoimmune hepatitis type 2","volume":"130","author":"Ma","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.autrev.2024.103591_bb0110","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/hep.21658","article-title":"Cytochrome P450IID6-specific CD8 T cell immune responses mirror disease activity in autoimmune hepatitis type 2","volume":"46","author":"Longhi","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.autrev.2024.103591_bb0115","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1002\/hep.22914","article-title":"Vigorous activation of monocytes in juvenile autoimmune liver disease escapes the control of regulatory T-cells","volume":"50","author":"Longhi","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.autrev.2024.103591_bb0120","article-title":"Interleukin-17 contributes to the pathogenesis of autoimmune hepatitis through inducing hepatic interleukin-6 expression","volume":"6","author":"Zhao","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.autrev.2024.103591_bb0125","doi-asserted-by":"crossref","first-page":"277","DOI":"10.4049\/jimmunol.169.1.277","article-title":"Key residues of a major cytochrome P4502D6 epitope are located on the surface of the molecule","volume":"169","author":"Ma","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2024.103591_bb0130","doi-asserted-by":"crossref","first-page":"1076594","DOI":"10.3389\/fimmu.2022.1076594","article-title":"The immunological characteristics of TSPAN1 expressing B cells in autoimmune hepatitis","volume":"13","author":"Ou","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.autrev.2024.103591_bb0135","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1073\/pnas.75.3.1549","article-title":"Alteration in suppressor cell activity in chronic active hepatitis","volume":"75","author":"Hodgson","year":"1978","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.autrev.2024.103591_bb0140","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jhep.2004.03.008","article-title":"Impairment of CD4(+)CD25(+) regulatory T-cells in autoimmune liver disease","volume":"41","author":"Longhi","year":"2004","journal-title":"J Hepatol"},{"key":"10.1016\/j.autrev.2024.103591_bb0145","doi-asserted-by":"crossref","first-page":"4484","DOI":"10.4049\/jimmunol.176.7.4484","article-title":"Functional study of CD4+CD25+ regulatory T cells in health and autoimmune hepatitis","volume":"176","author":"Longhi","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2024.103591_bb0150","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1002\/hep.24039","article-title":"Autoantigen-specific regulatory T cells, a potential tool for immune-tolerance reconstitution in type-2 autoimmune hepatitis","volume":"53","author":"Longhi","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.autrev.2024.103591_bb0155","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jaut.2012.12.003","article-title":"T-regs in autoimmune hepatitis-systemic lupus erythematosus\/mixed connective tissue disease overlap syndrome are functionally defective and display a Th1 cytokine profile","volume":"41","author":"Longhi","year":"2013","journal-title":"J Autoimmun"},{"key":"10.1016\/j.autrev.2024.103591_bb0160","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/hep.1840120208","article-title":"Class I and class II major histocompatibility complex antigen expression on hepatocytes: a study in children with liver disease","volume":"12","author":"Lobo-Yeo","year":"1990","journal-title":"Hepatology"},{"key":"10.1016\/j.autrev.2024.103591_bb0165","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1136\/adc.67.12.1447","article-title":"Immunohistochemical features of the portal tract mononuclear cell infiltrate in chronic aggressive hepatitis","volume":"67","author":"Senaldi","year":"1992","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.autrev.2024.103591_bb0170","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0140-6736(76)91472-0","article-title":"Antibody-dependent cell-mediated (K cell) cytotoxicity against isolated hepatocytes in chronic active hepatitis","volume":"1","author":"Cochrane","year":"1976","journal-title":"Lancet"},{"key":"10.1016\/j.autrev.2024.103591_bb0175","first-page":"16","article-title":"Lymphocyte cytotoxicity to autologous hepatocytes in HBsAg-negative chronic active hepatitis","volume":"38","author":"Vergani","year":"1979","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.autrev.2024.103591_bb0180","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1002\/hep.20109","article-title":"A murine model of type 2 autoimmune hepatitis: Xenoimmunization with human antigens","volume":"39","author":"Lapierre","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.autrev.2024.103591_bb0185","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jaut.2013.05.001","article-title":"Mechanism of autoimmune hepatic fibrogenesis induced by an adenovirus encoding the human liver autoantigen cytochrome P450 2D6","volume":"44","author":"Hintermann","year":"2013","journal-title":"J Autoimmun"},{"key":"10.1016\/j.autrev.2024.103591_bb0190","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1084\/jem.20071859","article-title":"Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection","volume":"205","author":"Holdener","year":"2008","journal-title":"J Exp Med"},{"key":"10.1016\/j.autrev.2024.103591_bb0195","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jaut.2012.11.001","article-title":"Molecular mimicry rather than identity breaks T-cell tolerance in the CYP2D6 mouse model for human autoimmune hepatitis","volume":"42","author":"Ehser","year":"2013","journal-title":"J Autoimmun"},{"key":"10.1016\/j.autrev.2024.103591_bb0200","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1002\/hep.26380","article-title":"Genetic predisposition and environmental danger signals initiate chronic autoimmune hepatitis driven by CD4+ T cells","volume":"58","author":"Hardtke-Wolenski","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.autrev.2024.103591_bb0205","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1136\/jclinpath-2016-204271","article-title":"Biliary diseases study group of, acute presentation of autoimmune hepatitis: a multicentre study with detailed histological evaluation in a large cohort of patients","volume":"70","author":"Nguyen Canh","year":"2017","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.autrev.2024.103591_bb0210","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1097\/MPG.0000000000003538","article-title":"Expression of HLA and autoimmune pathway genes in liver biopsies of young subjects with autoimmune hepatitis type 1","volume":"75","author":"Shin","year":"2022","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.autrev.2024.103591_bb0215","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.humimm.2007.03.010","article-title":"Elevated serum BAFF levels in patients with autoimmune hepatitis","volume":"68","author":"Migita","year":"2007","journal-title":"Hum Immunol"},{"key":"10.1016\/j.autrev.2024.103591_bb0220","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1600-0676.1987.tb00361.x","article-title":"Immunoglobulin on the surface of isolated hepatocytes is associated with antibody-dependent cell-mediated cytotoxicity and liver damage","volume":"7","author":"Vergani","year":"1987","journal-title":"Liver"},{"key":"10.1016\/j.autrev.2024.103591_bb0225","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJM197807062990101","article-title":"Detection of antibodies directed against a liver-specific membrane lipoprotein in patients with acute and chronic active hepatitis","volume":"299","author":"Jensen","year":"1978","journal-title":"N Engl J Med"},{"key":"10.1016\/j.autrev.2024.103591_bb0230","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/S0168-8278(86)80026-5","article-title":"Serum autoantibodies reacting with the hepatic asialoglycoprotein receptor protein (hepatic lectin) in acute and chronic liver disorders","volume":"3","author":"McFarlane","year":"1986","journal-title":"J Hepatol"},{"key":"10.1016\/j.autrev.2024.103591_bb0235","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1053\/gast.1997.v112.pm9024302","article-title":"Alcohol dehydrogenase: a target of humoral autoimmune response in liver disease","volume":"112","author":"Ma","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1016\/j.autrev.2024.103591_bb0240","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1136\/gut.46.4.553","article-title":"Liver\/kidney microsomal antibody type 1 targets CYP2D6 on hepatocyte plasma membrane","volume":"46","author":"Muratori","year":"2000","journal-title":"Gut"},{"key":"10.1016\/j.autrev.2024.103591_bb0245","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1172\/JCI115443","article-title":"LKM-1 autoantibodies recognize a short linear sequence in P450IID6, a cytochrome P-450 monooxygenase","volume":"88","author":"Manns","year":"1991","journal-title":"J Clin Invest"},{"key":"10.1016\/j.autrev.2024.103591_bb0250","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1002\/eji.1830230519","article-title":"Identification and analysis of cytochrome P450IID6 antigenic sites recognized by anti-liver-kidney microsome type-1 antibodies (LKM1)","volume":"23","author":"Yamamoto","year":"1993","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.autrev.2024.103591_bb0255","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.4049\/jimmunol.170.3.1481","article-title":"Cytochrome P4502D6(193-212): a new immunodominant epitope and target of virus\/self cross-reactivity in liver kidney microsomal autoantibody type 1-positive liver disease","volume":"170","author":"Kerkar","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2024.103591_bb0260","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1002\/hep.510280502","article-title":"Immunological cross-reactivity to multiple autoantigens in patients with liver kidney microsomal type 1 autoimmune hepatitis","volume":"28","author":"Choudhuri","year":"1998","journal-title":"Hepatology"},{"key":"10.1016\/j.autrev.2024.103591_bb0265","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1053\/jhep.2002.32092","article-title":"Antibodies to conformational epitopes of soluble liver antigen define a severe form of autoimmune liver disease","volume":"35","author":"Ma","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.autrev.2024.103591_bb0270","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/271067a0","article-title":"Antibody to nuclear ribonucleoprotein penetrates live human mononuclear cells through fc receptors","volume":"271","author":"Alarcon-Segovia","year":"1978","journal-title":"Nature"},{"key":"10.1016\/j.autrev.2024.103591_bb0275","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1006\/jaut.1996.0038","article-title":"The penetration of autoantibodies into cells may induce tolerance to self by apoptosis of autoreactive lymphocytes and cause autoimmune disease by dysregulation and\/or cell damage","volume":"9","author":"Alarcon-Segovia","year":"1996","journal-title":"J Autoimmun"},{"key":"10.1016\/j.autrev.2024.103591_bb0280","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1002\/eji.200323857","article-title":"Characterization of the B cell response of patients with anti-liver cytosol autoantibodies in type 2 autoimmune hepatitis","volume":"33","author":"Lapierre","year":"2003","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.autrev.2024.103591_bb0285","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s00430-012-0287-5","article-title":"Involvement of (IgG and IgM)-secreting B lymphocytes in severity of autoimmune hepatitis type 1","volume":"202","author":"Zgair","year":"2013","journal-title":"Med Microbiol Immunol"},{"key":"10.1016\/j.autrev.2024.103591_bb0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2023.109876","article-title":"Presence of ectopic germinal center structures in autoimmune hepatitis","volume":"259","author":"Huard","year":"2024","journal-title":"Clin Immunol"},{"key":"10.1016\/j.autrev.2024.103591_bb0295","doi-asserted-by":"crossref","first-page":"25","DOI":"10.15403\/jgld.2014.1121.amb","article-title":"Autoimmune liver diseases and antiphospholipid antibodies positivity: a meta-analysis of literature studies","volume":"24","author":"Ambrosino","year":"2015","journal-title":"J Gastrointestin Liver Dis"},{"key":"10.1016\/j.autrev.2024.103591_bb0300","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.autrev.2011.12.007","article-title":"Post-translational oxidative modification of beta2-glycoprotein I and its role in the pathophysiology of the antiphospholipid syndrome","volume":"11","author":"Mirarabshahi","year":"2012","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.autrev.2024.103591_bb0305","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.clim.2015.07.001","article-title":"Liver injury correlates with biomarkers of autoimmunity and disease activity and represents an organ system involvement in patients with systemic lupus erythematosus","volume":"160","author":"Liu","year":"2015","journal-title":"Clin Immunol"},{"key":"10.1016\/j.autrev.2024.103591_bb0310","first-page":"2728","article-title":"Mitochondrial dysfunction in the liver and antiphospholipid antibody production precede disease onset and respond to rapamycin in lupus-prone mice, arthritis","volume":"68","author":"Oaks","year":"2016","journal-title":"Rheumatology"},{"key":"10.1016\/j.autrev.2024.103591_bb0315","doi-asserted-by":"crossref","DOI":"10.1097\/HC9.0000000000000088","article-title":"Salvage therapies of autoimmune hepatitis limit proinflammatory immune cells while sparing regulatory T cells","volume":"7","author":"Derben","year":"2023","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.autrev.2024.103591_bb0320","doi-asserted-by":"crossref","first-page":"1053216","DOI":"10.3389\/fimmu.2022.1053216","article-title":"Standard immunosuppressive treatment reduces regulatory B cells in children with autoimmune liver disease","volume":"13","author":"Yuksel","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.autrev.2024.103591_bb0325","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/0140-6736(90)93306-A","article-title":"T-cell-directed hepatocyte damage in autoimmune chronic active hepatitis","volume":"336","author":"Wen","year":"1990","journal-title":"Lancet"},{"key":"10.1016\/j.autrev.2024.103591_bb0330","doi-asserted-by":"crossref","first-page":"379","DOI":"10.2174\/1566524013363672","article-title":"Pediatric autoimmune liver diseases: the molecular basis of humoral and cellular immunity","volume":"1","author":"Wen","year":"2001","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.autrev.2024.103591_bb0335","first-page":"17","article-title":"Cellular and humoral immune reactions in chronic active liver disease. I. Lymphocyte subsets in liver biopsies of patients with untreated idiopathic autoimmune hepatitis, chronic active hepatitis B and primary biliary cirrhosis","volume":"50","author":"Eggink","year":"1982","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.autrev.2024.103591_bb0340","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1055\/s-2008-1040437","article-title":"Ultrastructural lesion in autoimmune hepatitis and steps of the immune response in liver tissue","volume":"11","author":"Dienes","year":"1991","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.autrev.2024.103591_bb0345","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/hep.1840150403","article-title":"The histological features of chronic hepatitis C and autoimmune chronic hepatitis: a comparative analysis","volume":"15","author":"Bach","year":"1992","journal-title":"Hepatology"},{"key":"10.1016\/j.autrev.2024.103591_bb0350","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1365-2249.1991.tb08164.x","article-title":"Clonal analysis of liver-infiltrating T cells in patients with LKM-1 antibody-positive autoimmune chronic active hepatitis","volume":"84","author":"Lohr","year":"1991","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.autrev.2024.103591_bb0355","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1002\/hep.510240619","article-title":"Autoreactive CD4+ LKM-specific and anticlonotypic T-cell responses in LKM-1 antibody-positive autoimmune hepatitis","volume":"24","author":"Lohr","year":"1996","journal-title":"Hepatology"},{"key":"10.1016\/j.autrev.2024.103591_bb0360","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.humimm.2004.03.004","article-title":"Simultaneous expression of Th1 cytokines and IL-4 confers severe characteristics to type I autoimmune hepatitis in children","volume":"65","author":"Chernavsky","year":"2004","journal-title":"Hum Immunol"},{"key":"10.1016\/j.autrev.2024.103591_bb0365","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.humimm.2010.10.019","article-title":"Association of TBX21 promoter polymorphisms with type 1 autoimmune hepatitis in a Chinese population","volume":"72","author":"Chen","year":"2011","journal-title":"Hum Immunol"},{"key":"10.1016\/j.autrev.2024.103591_bb0370","doi-asserted-by":"crossref","first-page":"3148","DOI":"10.4049\/jimmunol.1900124","article-title":"TNF-producing Th1 cells are selectively expanded in liver infiltrates of patients with autoimmune hepatitis","volume":"203","author":"Bovensiepen","year":"2019","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2024.103591_bb0375","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/j.jhep.2020.05.053","article-title":"Integrative molecular profiling of autoreactive CD4 T cells in autoimmune hepatitis","volume":"73","author":"Renand","year":"2020","journal-title":"J Hepatol"},{"key":"10.1016\/j.autrev.2024.103591_bb0380","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/cei.12956","article-title":"Immunosuppressive drugs affect interferon (IFN)-gamma and programmed cell death 1 (PD-1) kinetics in patients with newly diagnosed autoimmune hepatitis","volume":"189","author":"Grant","year":"2017","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.autrev.2024.103591_bb0385","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/j.1399-3046.2012.01723.x","article-title":"Immunohistochemical phenotyping of the inflammatory infiltrate in de novo autoimmune hepatitis after liver transplantation in children","volume":"16","author":"Hadzic","year":"2012","journal-title":"Pediatr Transplant"},{"key":"10.1016\/j.autrev.2024.103591_bb0390","first-page":"7964654","article-title":"Serum levels of IL-33 and correlation with IL-4, IL-17A, and hypergammaglobulinemia in patients with autoimmune hepatitis","author":"Liang","year":"2018","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.autrev.2024.103591_bb0395","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jaut.2016.05.005","article-title":"CD39 mediated regulation of Th17-cell effector function is impaired in juvenile autoimmune liver disease","volume":"72","author":"Liberal","year":"2016","journal-title":"J Autoimmun"},{"key":"10.1016\/j.autrev.2024.103591_bb0400","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jhep.2020.06.044","article-title":"Altered aryl-hydrocarbon-receptor signalling affects regulatory and effector cell immunity in autoimmune hepatitis","volume":"74","author":"Vuerich","year":"2021","journal-title":"J Hepatol"},{"key":"10.1016\/j.autrev.2024.103591_bb0405","article-title":"Silencing of aryl hydrocarbon receptor repressor restrains Th17 cell immunity in autoimmune hepatitis","volume":"143","author":"Gao","year":"2023","journal-title":"J Autoimmun"},{"key":"10.1016\/j.autrev.2024.103591_bb0410","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/ni.1770","article-title":"Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2 cells","volume":"10","author":"Trifari","year":"2009","journal-title":"Nat Immunol"},{"key":"10.1016\/j.autrev.2024.103591_bb0415","doi-asserted-by":"crossref","first-page":"3753081","DOI":"10.1155\/2018\/3753081","article-title":"The imbalance between Foxp3(+)Tregs and Th1\/Th17\/Th22 cells in patients with newly diagnosed autoimmune hepatitis","volume":"2018","author":"Liang","year":"2018","journal-title":"J Immunol Res"},{"key":"10.1016\/j.autrev.2024.103591_bb0420","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/liv.12245","article-title":"Tfh and plasma cells are correlated with hypergammaglobulinaemia in patients with autoimmune hepatitis","volume":"34","author":"Ma","year":"2014","journal-title":"Liver Int"},{"key":"10.1016\/j.autrev.2024.103591_bb0425","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1186\/s40064-016-2512-y","article-title":"Interleukin-21 plays a critical role in the pathogenesis and severity of type I autoimmune hepatitis","volume":"5","author":"Abe","year":"2016","journal-title":"Springerplus"},{"key":"10.1016\/j.autrev.2024.103591_bb0430","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1002\/hep.510250504","article-title":"Clonotypic analysis of T cells in patients with autoimmune and viral hepatitis","volume":"25","author":"Tanaka","year":"1997","journal-title":"Hepatology"},{"key":"10.1016\/j.autrev.2024.103591_bb0435","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1007\/s12016-014-8432-0","article-title":"Emperipolesis mediated by CD8 T cells is a characteristic histopathologic feature of autoimmune hepatitis","volume":"48","author":"Miao","year":"2015","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.autrev.2024.103591_bb0440","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/1751-2980.12995","article-title":"CD8(+) T cells actively penetrate hepatocytes via the CD44\/p-ERM\/F-actin pathway in autoimmune hepatitis","volume":"22","author":"Liang","year":"2021","journal-title":"J Dig Dis"},{"key":"10.1016\/j.autrev.2024.103591_bb0445","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1002\/hep.31739","article-title":"The clinical significance of hepatic CD69(+) CD103(+) CD8(+) resident-memory T cells in autoimmune hepatitis","volume":"74","author":"You","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.autrev.2024.103591_bb0450","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/S0140-6736(84)91691-X","article-title":"Antigen specific suppressor cell function in autoimmune chronic active hepatitis","volume":"1","author":"Vento","year":"1984","journal-title":"Lancet"},{"key":"10.1016\/j.autrev.2024.103591_bb0455","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1053\/jhep.2001.22131","article-title":"Autoimmune hepatitis\/sclerosing cholangitis overlap syndrome in childhood: a 16-year prospective study","volume":"33","author":"Gregorio","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.autrev.2024.103591_bb0460","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jaut.2018.10.008","article-title":"Autoimmune sclerosing cholangitis: evidence and open questions","volume":"95","author":"Terziroli Beretta-Piccoli","year":"2018","journal-title":"J Autoimmun"},{"key":"10.1016\/j.autrev.2024.103591_bb0465","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jaut.2005.05.001","article-title":"Effect of CD4+ CD25+ regulatory T-cells on CD8 T-cell function in patients with autoimmune hepatitis","volume":"25","author":"Longhi","year":"2005","journal-title":"J Autoimmun"},{"key":"10.1016\/j.autrev.2024.103591_bb0470","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/hep4.1163","article-title":"Changes in natural killer cells and exhausted memory regulatory T cells with corticosteroid therapy in acute autoimmune hepatitis","volume":"2","author":"Jeffery","year":"2018","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.autrev.2024.103591_bb0475","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/hep.27884","article-title":"In autoimmune hepatitis type 1 or the autoimmune hepatitis-sclerosing cholangitis variant defective regulatory T-cell responsiveness to IL-2 results in low IL-10 production and impaired suppression","volume":"62","author":"Liberal","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.autrev.2024.103591_bb0480","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1002\/hep.23792","article-title":"A multifaceted imbalance of T cells with regulatory function characterizes type 1 autoimmune hepatitis","volume":"52","author":"Ferri","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.autrev.2024.103591_bb0485","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jhep.2012.02.029","article-title":"FOXP3+ regulatory T cells in autoimmune hepatitis are fully functional and not reduced in frequency","volume":"57","author":"Peiseler","year":"2012","journal-title":"J Hepatol"},{"key":"10.1016\/j.autrev.2024.103591_bb0490","doi-asserted-by":"crossref","first-page":"4040","DOI":"10.4049\/jimmunol.1502276","article-title":"Production of proinflammatory cytokines by monocytes in liver-transplanted recipients with De Novo autoimmune hepatitis is enhanced and induces TH1-like regulatory T cells","volume":"196","author":"Arterbery","year":"2016","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2024.103591_bb0495","doi-asserted-by":"crossref","first-page":"6204","DOI":"10.12659\/MSM.915408","article-title":"Foxp3(+) Treg cells are associated with pathological process of autoimmune hepatitis by activating methylation modification in autoimmune hepatitis patients","volume":"25","author":"Chen","year":"2019","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.autrev.2024.103591_bb0500","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0181107","article-title":"Pediatric autoimmune hepatitis shows a disproportionate decline of regulatory T cells in the liver and of IL-2 in the blood of patients undergoing therapy","volume":"12","author":"Diestelhorst","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.autrev.2024.103591_bb0505","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.jhep.2014.05.034","article-title":"Intrahepatic regulatory T cells in autoimmune hepatitis are associated with treatment response and depleted with current therapies","volume":"61","author":"Taubert","year":"2014","journal-title":"J Hepatol"},{"key":"10.1016\/j.autrev.2024.103591_bb0510","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1002\/hep4.1202","article-title":"Immune alterations in patients with type 1 autoimmune hepatitis persist upon standard immunosuppressive treatment","volume":"2","author":"Renand","year":"2018","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.autrev.2024.103591_bb0515","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1002\/hep.27998","article-title":"A novel \u201chumanized mouse\u201d model for autoimmune hepatitis and the association of gut microbiota with liver inflammation","volume":"62","author":"Yuksel","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.autrev.2024.103591_bb0520","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/cei.12843","article-title":"The induction of autoimmune hepatitis in the human leucocyte antigen-DR4 non-obese diabetic mice autoimmune hepatitis mouse model","volume":"186","author":"Yuksel","year":"2016","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.autrev.2024.103591_bb0525","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/hep.26023","article-title":"Adoptive transfer of ex vivo expanded regulatory T cells in an autoimmune hepatitis murine model restores peripheral tolerance","volume":"57","author":"Lapierre","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.autrev.2024.103591_bb0530","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2021.102619","article-title":"Regulatory T cells in autoimmune hepatitis: an updated overview","volume":"119","author":"Longhi","year":"2021","journal-title":"J Autoimmun"},{"key":"10.1016\/j.autrev.2024.103591_bb0535","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/s41577-019-0232-6","article-title":"Treg cell-based therapies: challenges and perspectives","volume":"20","author":"Raffin","year":"2020","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.autrev.2024.103591_bb0540","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/hep.25682","article-title":"The impaired immune regulation of autoimmune hepatitis is linked to a defective galectin-9\/tim-3 pathway","volume":"56","author":"Liberal","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.autrev.2024.103591_bb0545","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1002\/hep.26583","article-title":"Dysfunctional CD39(POS) regulatory T cells and aberrant control of T-helper type 17 cells in autoimmune hepatitis","volume":"59","author":"Grant","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.autrev.2024.103591_bb0550","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.it.2014.08.003","article-title":"Metabolic control of regulatory T cell development and function","volume":"36","author":"Zeng","year":"2015","journal-title":"Trends Immunol"},{"key":"10.1016\/j.autrev.2024.103591_bb0555","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/imr.12845","article-title":"mTOR signaling at the crossroads of environmental signals and T-cell fate decisions","volume":"295","author":"Huang","year":"2020","journal-title":"Immunol Rev"},{"key":"10.1016\/j.autrev.2024.103591_bb0560","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.immuni.2009.04.014","article-title":"The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment","volume":"30","author":"Delgoffe","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.autrev.2024.103591_bb0565","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s42255-022-00711-9","article-title":"Cytosolic aldose metabolism contributes to progression from cirrhosis to hepatocarcinogenesis","volume":"5","author":"Oaks","year":"2023","journal-title":"Nat Metab"},{"key":"10.1016\/j.autrev.2024.103591_bb0570","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2023.103112","article-title":"mTOR-dependent loss of PON1 secretion and antiphospholipid autoantibody production underlie autoimmunity-mediated cirrhosis in transaldolase deficiency","volume":"140","author":"Winans","year":"2023","journal-title":"J Autoimmun"},{"key":"10.1016\/j.autrev.2024.103591_bb0575","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1189\/jlb.2AB0613-342RR","article-title":"Hepatocytes induce Foxp3(+) regulatory T cells by notch signaling","volume":"96","author":"Burghardt","year":"2014","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.autrev.2024.103591_bb0580","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/hep.22071","article-title":"Expansion and de novo generation of potentially therapeutic regulatory T cells in patients with autoimmune hepatitis","volume":"47","author":"Longhi","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.autrev.2024.103591_bb0585","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jaut.2014.02.001","article-title":"Retinoic acid stabilizes antigen-specific regulatory T-cell function in autoimmune hepatitis type 2","volume":"53","author":"Holder","year":"2014","journal-title":"J Autoimmun"},{"key":"10.1016\/j.autrev.2024.103591_bb0590","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1038\/s41467-019-09893-5","article-title":"Suppression of a broad spectrum of liver autoimmune pathologies by single peptide-MHC-based nanomedicines","volume":"10","author":"Umeshappa","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.autrev.2024.103591_bb0595","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.jhepr.2019.08.001","article-title":"Liver homing of clinical grade Tregs after therapeutic infusion in patients with autoimmune hepatitis","volume":"1","author":"Oo","year":"2019","journal-title":"JHEP Rep"},{"key":"10.1016\/j.autrev.2024.103591_bb0600","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.bbrc.2019.02.147","article-title":"Adoptive transfer of regulatory T cells stimulated by allogeneic hepatic stellate cells mitigates liver injury in mice with concanavalin A-induced autoimmune hepatitis","volume":"512","author":"Huang","year":"2019","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.autrev.2024.103591_bb0605","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1136\/annrheumdis-2018-214229","article-title":"Immunological and clinical effects of low-dose interleukin-2 across 11 autoimmune diseases in a single, open clinical trial","volume":"78","author":"Rosenzwajg","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2024.103591_bb0610","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2024.103172","article-title":"The universal effects of low-dose interleukin-2 across 13 autoimmune diseases in a basket clinical trial","volume":"144","author":"Lorenzon","year":"2024","journal-title":"J Autoimmun"},{"key":"10.1016\/j.autrev.2024.103591_bb0615","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1002\/hep.30059","article-title":"Low-dose Interleukin-2 for refractory autoimmune hepatitis","volume":"68","author":"Lim","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.autrev.2024.103591_bb0620","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/cei\/uxac105","article-title":"IL-2-based approaches to Treg enhancement","volume":"211","author":"Harris","year":"2023","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.autrev.2024.103591_bb0625","article-title":"Treg-specific IL-2 therapy can reestablish intrahepatic immune regulation in autoimmune hepatitis","volume":"117","author":"Buitrago-Molina","year":"2020","journal-title":"J Autoimmun"},{"key":"10.1016\/j.autrev.2024.103591_bb0630","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abb9283","article-title":"Receptor-gated IL-2 delivery by an anti-human IL-2 antibody activates regulatory T cells in three different species","volume":"12","author":"Karakus","year":"2020","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.autrev.2024.103591_bb0635","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/liv.12498","article-title":"Low-dose anti-CD3 antibody induces remission of active autoimmune hepatitis in xenoimmunized mice","volume":"35","author":"Marceau","year":"2015","journal-title":"Liver Int"},{"key":"10.1016\/j.autrev.2024.103591_bb0640","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.jhep.2012.11.010","article-title":"Infliximab as a rescue treatment in difficult-to-treat autoimmune hepatitis","volume":"58","author":"Weiler-Normann","year":"2013","journal-title":"J Hepatol"},{"key":"10.1016\/j.autrev.2024.103591_bb0645","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1046\/j.1365-2249.2001.01391.x","article-title":"Increase of chemokine interferon-inducible protein-10 (IP-10) in the serum of patients with autoimmune liver diseases and increase of its mRNA expression in hepatocytes","volume":"123","author":"Nishioji","year":"2001","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.autrev.2024.103591_bb0650","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/apt.12825","article-title":"Review article: chemokines as orchestrators of autoimmune hepatitis and potential therapeutic targets","volume":"40","author":"Czaja","year":"2014","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.autrev.2024.103591_bb0655","first-page":"113","article-title":"Liver, blood proteins and nutritive protein","volume":"9","author":"Waldenstrom","year":"1953","journal-title":"Dtsch Z Verdau Stoffwechselkr"},{"key":"10.1016\/j.autrev.2024.103591_bb0660","first-page":"1323","article-title":"Lupoid hepatitis","volume":"271","author":"Cowling","year":"1956","journal-title":"Lancet"},{"key":"10.1016\/j.autrev.2024.103591_bb0665","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1084\/jem.20040139","article-title":"In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes","volume":"199","author":"Tang","year":"2004","journal-title":"J Exp Med"},{"key":"10.1016\/j.autrev.2024.103591_bb0670","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1084\/jem.20040180","article-title":"CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes","volume":"199","author":"Tarbell","year":"2004","journal-title":"J Exp Med"},{"key":"10.1016\/j.autrev.2024.103591_bb0675","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1002\/eji.200839073","article-title":"Curing CNS autoimmune disease with myelin-reactive Foxp3+ Treg","volume":"39","author":"Stephens","year":"2009","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.autrev.2024.103591_bb0680","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1172\/JCI17702","article-title":"Recipient-type specific CD4+CD25+ regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus-leukemia","volume":"112","author":"Trenado","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.autrev.2024.103591_bb0685","doi-asserted-by":"crossref","first-page":"3120","DOI":"10.2174\/138161211798157568","article-title":"Promising pharmacological, molecular and cellular treatments of autoimmune hepatitis","volume":"17","author":"Czaja","year":"2011","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.autrev.2024.103591_bb0690","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/S0952-7915(00)00166-7","article-title":"Antigen-specific therapy for autoimmune disease","volume":"12","author":"Harrison","year":"2000","journal-title":"Curr Opin Immunol"}],"container-title":["Autoimmunity Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156899722400082X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156899722400082X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T09:53:27Z","timestamp":1725530007000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156899722400082X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":138,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["S156899722400082X"],"URL":"https:\/\/doi.org\/10.1016\/j.autrev.2024.103591","relation":{},"ISSN":["1568-9972"],"issn-type":[{"value":"1568-9972","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"B and T cells: (Still) the dominant orchestrators in autoimmune hepatitis","name":"articletitle","label":"Article Title"},{"value":"Autoimmunity Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.autrev.2024.103591","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103591"}}