{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:47:28Z","timestamp":1793213248492,"version":"4.5.0"},"reference-count":166,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Autoimmunity Reviews"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.autrev.2025.103757","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T12:30:46Z","timestamp":1737549046000},"page":"103757","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["CD4+CD8+ double-positive T cells in immune disorders and cancer: Prospects and hurdles in immunotherapy"],"prefix":"10.1016","volume":"24","author":[{"given":"Md Rakibul","family":"Alam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amos Olalekan","family":"Akinyemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianlin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mithu","family":"Howlader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Esfini","family":"Farahani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Nur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixiang","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiguo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.autrev.2025.103757_bb0005","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.immuni.2018.01.007","article-title":"Human T cell development, localization, and function throughout life","volume":"48","author":"Kumar","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.autrev.2025.103757_bb0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.ai.2014.09.001","article-title":"Regulation of CD4 and CD8 coreceptor expression and CD4 versus CD8 lineage decisions","volume":"125","author":"Egawa","year":"2015","journal-title":"Adv Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0015","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.immuni.2012.09.020","article-title":"Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets","volume":"38","author":"Sathaliyawala","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.autrev.2025.103757_bb0020","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1126\/science.1067833","article-title":"Signaling life and death in the thymus: timing is everything","volume":"299","author":"Werlen","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.autrev.2025.103757_bb0025","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nri2232","article-title":"Launching the T-cell-lineage developmental programme","volume":"8","author":"Rothenberg","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0030","doi-asserted-by":"crossref","first-page":"11612","DOI":"10.1038\/s41598-017-11926-2","article-title":"Peripheral human CD4+ CD8+ T lymphocytes exhibit a memory phenotype and enhanced responses to IL-2, IL-7 and IL-15","volume":"7","author":"Cl\u00e9net","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.autrev.2025.103757_bb0035","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1189\/jlb.1RU0814-382","article-title":"CD4+\/CD8+ double-positive T cells: more than just a developmental stage?","volume":"97","author":"Overgaard","year":"2015","journal-title":"J Leucocyte Biol"},{"key":"10.1016\/j.autrev.2025.103757_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.104021","article-title":"Intracellular metabolic adaptation of intraepithelial CD4+ CD8\u03b1\u03b1+ T lymphocytes","volume":"25","author":"Harada","year":"2022","journal-title":"Iscience"},{"key":"10.1016\/j.autrev.2025.103757_bb0045","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1111\/j.1365-2141.2007.06867.x","article-title":"Age-dependent accumulation of monoclonal CD4+ CD8+ double positive T lymphocytes in the peripheral blood of the elderly","volume":"139","author":"Ghia","year":"2007","journal-title":"Br J Haematol"},{"key":"10.1016\/j.autrev.2025.103757_bb0050","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.3389\/fimmu.2018.02728","article-title":"Renal cell carcinoma (RCC) tumors display large expansion of double positive (DP) CD4+ CD8+ T cells with expression of exhaustion markers","volume":"9","author":"Menard","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0055","doi-asserted-by":"crossref","first-page":"4289","DOI":"10.4049\/jimmunol.1103701","article-title":"CD4+ CD8+ T cells represent a significant portion of the anti-HIV T cell response to acute HIV infection","volume":"188","author":"Frahm","year":"2012","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0060","doi-asserted-by":"crossref","first-page":"622","DOI":"10.3389\/fimmu.2019.00622","article-title":"Double positive CD4+ CD8+ T cells are enriched in urological cancers and favor T helper-2 polarization","volume":"10","author":"Bohner","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0065","doi-asserted-by":"crossref","first-page":"3459","DOI":"10.1002\/art.22927","article-title":"Presence of CD4+ CD8+ double-positive T cells with very high interleukin-4 production potential in lesional skin of patients with systemic sclerosis","volume":"56","author":"Parel","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.autrev.2025.103757_bb0070","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/intimm\/dxaa004","article-title":"Clinical importance of the expression of CD4+ CD8+ T cells in renal cell carcinoma","volume":"32","author":"Nishida","year":"2020","journal-title":"Int Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0075","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.4049\/jimmunol.134.4.2281","article-title":"Coexpression of T4 and T8 on peripheral blood T cells demonstrated by two-color fluorescence flow cytometry","volume":"134","author":"Blue","year":"1985","journal-title":"J Immunol (Baltimore, Md: 1950)"},{"key":"10.1016\/j.autrev.2025.103757_bb0080","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1006\/bbrc.1993.1260","article-title":"Cytofluorometric identification of two populations of double positive (CD4+, CD8+) T lymphocytes in human peripheral blood","volume":"191","author":"Ortolani","year":"1993","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.autrev.2025.103757_bb0085","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1182\/blood-2003-12-4395","article-title":"Peripheral CD4+ CD8+ T cells are differentiated effector memory cells with antiviral functions","volume":"104","author":"Nascimbeni","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.autrev.2025.103757_bb0090","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1097\/00042737-199804000-00009","article-title":"CD4+ CD8+ and CD8\u03b1+ \u03b2-T lymphocytes in human small intestinal lamina propria","volume":"10","author":"Abuzakouk","year":"1998","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.autrev.2025.103757_bb0095","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S0168-8278(98)80206-7","article-title":"Resident human hepatitis lymphocytes are phenotypically different from circulating lymphocytes","volume":"28","author":"Norris","year":"1998","journal-title":"J Hepatol"},{"key":"10.1016\/j.autrev.2025.103757_bb0100","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1159\/000337051","article-title":"Influence of age, gender and lifestyle in lymphocyte subsets: report from the Spanish Gait-2 study","volume":"127","author":"Garc\u00eda-Dabrio","year":"2012","journal-title":"Acta Haematol"},{"key":"10.1016\/j.autrev.2025.103757_bb0105","first-page":"125","article-title":"Percentages and absolute numbers of CD4+ CD8+ Doublepositive T lymphocytes in the peripheral blood of normal Italian subjects: relationship with age and sex","volume":"37","author":"Marini","year":"2020","journal-title":"Turkish J Hematol"},{"key":"10.1016\/j.autrev.2025.103757_bb0110","series-title":"T cells and MHC proteins, molecular biology of the cell","author":"Alberts","year":"2002"},{"key":"10.1016\/j.autrev.2025.103757_bb0115","article-title":"Immune response to viruses","volume":"429","author":"Herbert","year":"2022","journal-title":"Encyclop Infect Immun"},{"key":"10.1016\/j.autrev.2025.103757_bb0120","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/nri913","article-title":"Development of \u03b1\u03b2 T cells in the human thymus","volume":"2","author":"Spits","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0125","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nri798","article-title":"T-cell development and the CD4\u2013CD8 lineage decision","volume":"2","author":"Germain","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0130","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/ni.2518","article-title":"Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4+ T cell immunity","volume":"14","author":"Reis","year":"2013","journal-title":"Nat Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0135","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1159\/000501963","article-title":"Inflammation and the alteration of B-cell physiology in aging","volume":"66","author":"Hagen","year":"2020","journal-title":"Gerontology"},{"key":"10.1016\/j.autrev.2025.103757_bb0140","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1046\/j.1365-2567.2001.01243.x","article-title":"Upregulation of CD4 on CD8+ T cells: CD4dimCD8bright T cells constitute an activated phenotype of CD8+ T cells","volume":"103","author":"Sullivan","year":"2001","journal-title":"Immunology"},{"key":"10.1016\/j.autrev.2025.103757_bb0145","doi-asserted-by":"crossref","first-page":"11555","DOI":"10.1128\/JVI.75.23.11555-11564.2001","article-title":"Activated peripheral CD8 lymphocytes express CD4 in vivo and are targets for infection by human immunodeficiency virus type 1","volume":"75","author":"Imlach","year":"2001","journal-title":"J Virol"},{"key":"10.1016\/j.autrev.2025.103757_bb0150","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1086\/515674","article-title":"Persistent expansion, in a human immunodeficiency virus-infected person, of V\u03b2-restricted CD4+ CD8+ T lymphocytes that express cytotoxicity-associated molecules and are committed to produce interferon-\u03b3 and tumor necrosis factor-\u03b1","volume":"178","author":"Weiss","year":"1998","journal-title":"J Infect Dis"},{"key":"10.1016\/j.autrev.2025.103757_bb0155","doi-asserted-by":"crossref","first-page":"5324","DOI":"10.1073\/pnas.0831037100","article-title":"An important regulatory role for CD4+ CD8\u03b1\u03b1 T cells in the intestinal epithelial layer in the prevention of inflammatory bowel disease","volume":"100","author":"Das","year":"2003","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.autrev.2025.103757_bb0160","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.molmed.2011.07.002","article-title":"Balancing acts: the role of TGF-\u03b2 in the mucosal immune system","volume":"17","author":"Konkel","year":"2011","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.autrev.2025.103757_bb0165","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.it.2017.11.003","article-title":"Intestinal intraepithelial lymphocytes: sentinels of the mucosal barrier","volume":"39","author":"Olivares-Villag\u00f3mez","year":"2018","journal-title":"Trends Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0170","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/sj.leu.2400978","article-title":"Phenotypical heterogeneity of CD4+ CD8+ double-positive chronic T lymphoid leukemia","volume":"12","author":"Mizuki","year":"1998","journal-title":"Leukemia"},{"key":"10.1016\/j.autrev.2025.103757_bb0175","doi-asserted-by":"crossref","first-page":"5605","DOI":"10.1038\/s41598-018-23774-9","article-title":"Global dynamics of stage-specific transcription factor binding during thymocyte development","volume":"8","author":"Hosoya","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.autrev.2025.103757_bb0180","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/ni791","article-title":"Regulation of the TCR\u03b1 repertoire by the survival window of CD4+ CD8+ thymocytes","volume":"3","author":"Guo","year":"2002","journal-title":"Nat Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0185","doi-asserted-by":"crossref","first-page":"7981","DOI":"10.4049\/jimmunol.175.12.7981","article-title":"Stabilized \u03b2-catenin extends thymocyte survival by up-regulating Bcl-xL","volume":"175","author":"Xie","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0190","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/90623","article-title":"The \u03b2-catenin\u2013TCF-1 pathway ensures CD4+ CD8+ thymocyte survival","volume":"2","author":"Ioannidis","year":"2001","journal-title":"Nat Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0195","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1126\/science.288.5475.2369","article-title":"Requirement for ROR\u03b3 in thymocyte survival and lymphoid organ development","volume":"288","author":"Sun","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.autrev.2025.103757_bb0200","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.4049\/jimmunol.0902846","article-title":"C-Myb promotes the survival of CD4+ CD8+ double-positive thymocytes through upregulation of Bcl-xL","volume":"184","author":"Yuan","year":"2010","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0205","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/ni.1845","article-title":"An essential role for the transcription factor HEB in thymocyte survival, Tcra rearrangement and the development of natural killer T cells","volume":"11","author":"D'cruz","year":"2010","journal-title":"Nat Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0210","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/1521-4141(200101)31:1<285::AID-IMMU285>3.0.CO;2-D","article-title":"Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription","volume":"31","author":"Staal","year":"2001","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0215","doi-asserted-by":"crossref","first-page":"3984","DOI":"10.4049\/jimmunol.161.8.3984","article-title":"Critical involvement of Tcf-1 in expansion of thymocytes","volume":"161","author":"Schilham","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0220","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1038\/ni1008","article-title":"Deletion of \u03b2-catenin impairs T cell development","volume":"4","author":"Xu","year":"2003","journal-title":"Nat Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0225","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1002\/1521-4141(200204)32:4<967::AID-IMMU967>3.0.CO;2-6","article-title":"Wnt-1 and Wnt-4 regulate thymic cellularity","volume":"32","author":"Mulroy","year":"2002","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0230","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/s41577-020-00426-6","article-title":"How transcription factors drive choice of the T cell fate","volume":"21","author":"Hosokawa","year":"2021","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0235","doi-asserted-by":"crossref","first-page":"eaaw7313","DOI":"10.1126\/sciadv.aaw7313","article-title":"Functional definition of a transcription factor hierarchy regulating T cell lineage commitment","volume":"6","author":"Garcia-Perez","year":"2020","journal-title":"Sci Adv"},{"key":"10.1016\/j.autrev.2025.103757_bb0240","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.immuni.2018.01.012","article-title":"Lineage-determining transcription factor TCF-1 initiates the epigenetic identity of T cells","volume":"48","author":"Johnson","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.autrev.2025.103757_bb0245","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/s41423-020-00527-1","article-title":"Exploring the stage-specific roles of Tcf-1 in T cell development and malignancy at single-cell resolution","volume":"18","author":"Wang","year":"2021","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13073-017-0481-6","article-title":"Nuclear Wiskott\u2013Aldrich syndrome protein co-regulates T cell factor 1-mediated transcription in T cells","volume":"9","author":"Kuznetsov","year":"2017","journal-title":"Genome Med"},{"key":"10.1016\/j.autrev.2025.103757_bb0255","doi-asserted-by":"crossref","first-page":"130","DOI":"10.3324\/haematol.2019.226126","article-title":"HES1 and HES4 have non-redundant roles downstream of notch during early human T-cell development","volume":"106","author":"De Decker","year":"2021","journal-title":"Haematologica"},{"key":"10.1016\/j.autrev.2025.103757_bb0260","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1600-065X.2010.00954.x","article-title":"From the cradle to the grave: activities of GATA-3 throughout T-cell development and differentiation","volume":"238","author":"Hosoya","year":"2010","journal-title":"Immunol Rev"},{"issue":"14","key":"10.1016\/j.autrev.2025.103757_bb0265","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1128\/MCB.01549-13","article-title":"Fbw7 targets GATA3 through cyclin-dependent kinase 2-dependent proteolysis and contributes to regulation of T-cell development","volume":"34","author":"Kitagawa","year":"2014","journal-title":"Mol Cell Biol."},{"issue":"5","key":"10.1016\/j.autrev.2025.103757_bb0270","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1128\/MCB.01034-10","article-title":"HEB-deficient T-cell precursors lose T-cell potential and adopt an alternative pathway of differentiation","volume":"31","author":"Braunstein","year":"2011","journal-title":"Mol Cell Biol."},{"key":"10.1016\/j.autrev.2025.103757_bb0275","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/ni927","article-title":"Bcl11b is required for differentiation and survival of \u03b1\u03b2 T lymphocytes","volume":"4","author":"Wakabayashi","year":"2003","journal-title":"Nat Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0280","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1139\/bcb-2018-0132","article-title":"Alteration of Bcl11b upon stimulation of both the MAP kinase-and Gsk3-dependent signaling pathways in double-negative thymocytes","volume":"97","author":"Selman","year":"2019","journal-title":"Biochem Cell Biol"},{"key":"10.1016\/j.autrev.2025.103757_bb0285","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1084\/jem.20122727","article-title":"Interleukin-7 receptor mutants initiate early T cell precursor leukemia in murine thymocyte progenitors with multipotent potential","volume":"211","author":"Treanor","year":"2014","journal-title":"J Exp Med"},{"key":"10.1016\/j.autrev.2025.103757_bb0290","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.imlet.2017.09.008","article-title":"In vivo blockade of T cell development reveals alternative pathways for generation of intraepithelial lymphocytes in mice","volume":"191","author":"Mondoon","year":"2017","journal-title":"Immunol Lett"},{"key":"10.1016\/j.autrev.2025.103757_bb0295","doi-asserted-by":"crossref","first-page":"11841","DOI":"10.1038\/ncomms11841","article-title":"A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia development","volume":"7","author":"Klein-Hessling","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.autrev.2025.103757_bb0300","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/ni.2507","article-title":"An alternative NFAT-activation pathway mediated by IL-7 is critical for early thymocyte development","volume":"14","author":"Patra","year":"2013","journal-title":"Nat Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0305","doi-asserted-by":"crossref","first-page":"5901","DOI":"10.1038\/s41467-022-33610-4","article-title":"Loss of Zfp335 triggers cGAS\/STING-dependent apoptosis of post-\u03b2 selection thymocytes","volume":"13","author":"Ratiu","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.autrev.2025.103757_bb0310","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.4049\/jimmunol.169.6.2866","article-title":"Enforced expression of Runx2 perturbs T cell development at a stage coincident with \u03b2-selection","volume":"169","author":"Vaillant","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0315","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1101\/gad.1901610","article-title":"Epigenetic propagation of CD4 expression is established by the Cd4 proximal enhancer in helper T cells","volume":"24","author":"Chong","year":"2010","journal-title":"Genes Dev"},{"key":"10.1016\/j.autrev.2025.103757_bb0320","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1182\/blood-2006-05-021188","article-title":"T-lymphoid, megakaryocyte, and granulocyte development are sensitive to decreases in CBF\u03b2 dosage","volume":"109","author":"Talebian","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.autrev.2025.103757_bb0325","doi-asserted-by":"crossref","DOI":"10.18632\/oncotarget.5796","article-title":"A genome wide transcriptional model of the complex response to pre-TCR signalling during thymocyte differentiation","volume":"6","author":"Sahni","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.autrev.2025.103757_bb0330","doi-asserted-by":"crossref","first-page":"6368","DOI":"10.4049\/jimmunol.1003567","article-title":"Pre-TCR signaling and CD8 gene bivalent chromatin resolution during thymocyte development","volume":"186","author":"Harker","year":"2011","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0335","article-title":"The transcriptional repressor Bcl6 promotes pre-TCR-induced thymocyte differentiation and attenuates Notch1 activation","volume":"147","author":"Solanki","year":"2020","journal-title":"Development"},{"key":"10.1016\/j.autrev.2025.103757_bb0340","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/435241","article-title":"A role for Bcl-2 in Notch1-dependent transcription in Thymic lymphoma cells","volume":"2012","author":"Sionov","year":"2012","journal-title":"Adv Hematol"},{"key":"10.1016\/j.autrev.2025.103757_bb0345","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/ni.3122","article-title":"IL-7 coordinates proliferation, differentiation and Tcra recombination during thymocyte \u03b2-selection","volume":"16","author":"Boudil","year":"2015","journal-title":"Nat Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0350","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1038\/ni.3232","article-title":"A discrete chromatin loop in the mouse Tcra-Tcrd locus shapes the TCR\u03b4 and TCR\u03b1 repertoires","volume":"16","author":"Chen","year":"2015","journal-title":"Nat Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0355","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.4049\/jimmunol.1500692","article-title":"Domain-specific and stage-intrinsic changes in Tcrb conformation during thymocyte development","volume":"195","author":"Majumder","year":"2015","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0360","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1182\/blood-2010-07-296616","article-title":"Lunatic fringe prolongs Delta\/notch-induced self-renewal of committed \u03b1\u03b2 T-cell progenitors","volume":"117","author":"Yuan","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.autrev.2025.103757_bb0365","doi-asserted-by":"crossref","first-page":"4609","DOI":"10.4049\/jimmunol.1002008","article-title":"Lunatic fringe enhances competition for delta-like notch ligands but does not overcome defective pre-TCR signaling during thymocyte \u03b2-selection in vivo","volume":"185","author":"Visan","year":"2010","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0370","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1182\/blood-2018-02-835850","article-title":"Stage-specific roles for Zmiz1 in Notch-dependent steps of early T-cell development","volume":"132","author":"Wang","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.autrev.2025.103757_bb0375","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004768","article-title":"SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cells","volume":"10","author":"Gerby","year":"2014","journal-title":"PLoS Genet"},{"issue":"6","key":"10.1016\/j.autrev.2025.103757_bb0380","doi-asserted-by":"crossref","first-page":"e1273","DOI":"10.1038\/cddis.2014.198","article-title":"FADD regulates thymocyte development at the \u03b2-selection checkpoint by modulating Notch signaling","volume":"5","author":"Zhang","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.autrev.2025.103757_bb0385","article-title":"Early growth response gene-2 (Egr-2) regulates the development of B and T cells","volume":"6","author":"Li","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.autrev.2025.103757_bb0390","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001430","article-title":"The nuclear effector of Wnt-signaling, Tcf1, functions as a T-cell\u2013specific tumor suppressor for development of lymphomas","volume":"10","author":"Tiemessen","year":"2012","journal-title":"PLoS Biol"},{"key":"10.1016\/j.autrev.2025.103757_bb0395","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1084\/jem.20070133071408c","article-title":"The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells","volume":"205","author":"Egawa","year":"2008","journal-title":"J Exp Med"},{"key":"10.1016\/j.autrev.2025.103757_bb0400","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1365-2567.2009.03230.x","article-title":"Over-expression of Runx1 transcription factor impairs the development of thymocytes from the double-negative to double-positive stages","volume":"130","author":"Wong","year":"2010","journal-title":"Immunology"},{"key":"10.1016\/j.autrev.2025.103757_bb0405","doi-asserted-by":"crossref","first-page":"3567","DOI":"10.1093\/nar\/gkv1475","article-title":"Dynamic recruitment of Ets1 to both nucleosome-occupied and-depleted enhancer regions mediates a transcriptional program switch during early T-cell differentiation","volume":"44","author":"Cauchy","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.autrev.2025.103757_bb0410","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molimm.2017.03.014","article-title":"Expression and splicing of Ikaros family members in murine and human thymocytes","volume":"87","author":"Mitchell","year":"2017","journal-title":"Mol Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0415","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1101\/gad.266999.115","article-title":"Regulation of gene expression dynamics during developmental transitions by the Ikaros transcription factor","volume":"29","author":"Arenzana","year":"2015","journal-title":"Genes Dev"},{"key":"10.1016\/j.autrev.2025.103757_bb0420","doi-asserted-by":"crossref","first-page":"ra28-ra28","DOI":"10.1126\/scisignal.2004545","article-title":"The tumor suppressor Ikaros shapes the repertoire of notch target genes in T cells","volume":"7","author":"Geimer Le Lay","year":"2014","journal-title":"Sci Signal"},{"key":"10.1016\/j.autrev.2025.103757_bb0425","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.4049\/jimmunol.1501916","article-title":"Yin Yang 1 promotes thymocyte survival by downregulating p53","volume":"196","author":"Chen","year":"2016","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0430","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/s41423-018-0002-6","article-title":"Transcription factor YY1 is essential for i NKT cell development","volume":"16","author":"Ou","year":"2019","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0435","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aam8939","article-title":"ROR\u03b3t limits the amount of the cytokine receptor \u03b3c through the prosurvival factor Bcl-xL in developing thymocytes","volume":"11","author":"Ligons","year":"2018","journal-title":"Sci Signal"},{"key":"10.1016\/j.autrev.2025.103757_bb0440","doi-asserted-by":"crossref","first-page":"5964","DOI":"10.4049\/jimmunol.1101205","article-title":"T cell factor 1 regulates thymocyte survival via a ROR\u03b3t-dependent pathway","volume":"187","author":"Wang","year":"2011","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0445","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1038\/s41423-020-0459-y","article-title":"Zeb1 represses TCR signaling, promotes the proliferation of T cell progenitors and is essential for NK1. 1+ T cell development","volume":"18","author":"Zhang","year":"2021","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0450","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.4049\/jimmunol.1701085","article-title":"Nur77 regulates nondeletional mechanisms of tolerance in T cells","volume":"199","author":"Hu","year":"2017","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0455","doi-asserted-by":"crossref","first-page":"5760","DOI":"10.1093\/nar\/gkab389","article-title":"NSrp70 is a lymphocyte-essential splicing factor that controls thymocyte development","volume":"49","author":"Kim","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.autrev.2025.103757_bb0460","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/ni1085","article-title":"Critical functions for c-Myb at three checkpoints during thymocyte development","volume":"5","author":"Bender","year":"2004","journal-title":"Nat Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0465","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1084\/jem.194.6.733","article-title":"Early thymocyte development is regulated by modulation of E2A protein activity","volume":"194","author":"Engel","year":"2001","journal-title":"J Exp Med"},{"key":"10.1016\/j.autrev.2025.103757_bb0470","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/sj.emboj.7600017","article-title":"E2A proteins enforce a proliferation checkpoint in developing thymocytes","volume":"23","author":"Engel","year":"2004","journal-title":"EMBO J"},{"issue":"18","key":"10.1016\/j.autrev.2025.103757_bb0475","doi-asserted-by":"crossref","first-page":"6677","DOI":"10.1128\/MCB.20.18.6677-6685.2000","article-title":"Functions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEB","volume":"20","author":"Barndt","year":"2000","journal-title":"Mol Cell Biol."},{"key":"10.1016\/j.autrev.2025.103757_bb0480","doi-asserted-by":"crossref","first-page":"5554","DOI":"10.1038\/s41467-022-33333-6","article-title":"Chromatin organizer SATB1 controls the cell identity of CD4+ CD8+ double-positive thymocytes by regulating the activity of super-enhancers","volume":"13","author":"Feng","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.autrev.2025.103757_bb0485","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1084\/jem.20142207","article-title":"An anti-silencer\u2013and SATB1-dependent chromatin hub regulates Rag1 and Rag2 gene expression during thymocyte development","volume":"212","author":"Hao","year":"2015","journal-title":"J Exp Med"},{"key":"10.1016\/j.autrev.2025.103757_bb0490","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1038\/ng1913","article-title":"SATB1 packages densely looped, transcriptionally active chromatin for coordinated expression of cytokine genes","volume":"38","author":"Cai","year":"2006","journal-title":"Nat Genet"},{"key":"10.1016\/j.autrev.2025.103757_bb0495","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.celrep.2017.04.038","article-title":"Essential roles of SATB1 in specifying T lymphocyte subsets","volume":"19","author":"Kakugawa","year":"2017","journal-title":"Cell Rep"},{"key":"10.1016\/j.autrev.2025.103757_bb0500","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1101\/gad.14.5.521","article-title":"The MAR-binding protein SATB1 orchestrates temporal and spatial expression of multiple genes during T-cell development","volume":"14","author":"Alvarez","year":"2000","journal-title":"Genes Dev"},{"key":"10.1016\/j.autrev.2025.103757_bb0505","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrm1963","article-title":"Poly (ADP-ribose): novel functions for an old molecule","volume":"7","author":"Schreiber","year":"2006","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.autrev.2025.103757_bb0510","doi-asserted-by":"crossref","first-page":"4350","DOI":"10.1038\/sj.emboj.7601301","article-title":"PARP-2 deficiency affects the survival of CD4+ CD8+ double-positive thymocytes","volume":"25","author":"Y\u00e9lamos","year":"2006","journal-title":"EMBO J"},{"key":"10.1016\/j.autrev.2025.103757_bb0515","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/ni.2301","article-title":"Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling","volume":"13","author":"Wang","year":"2012","journal-title":"Nat Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0520","doi-asserted-by":"crossref","first-page":"15732","DOI":"10.1038\/ncomms15732","article-title":"Tespa1 regulates T cell receptor-induced calcium signals by recruiting inositol 1, 4, 5-trisphosphate receptors","volume":"8","author":"Liang","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.autrev.2025.103757_bb0525","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/s41423-019-0259-4","article-title":"Thymic-specific regulation of TCR signaling by Tespa1","volume":"16","author":"Lyu","year":"2019","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0530","doi-asserted-by":"crossref","first-page":"E67","DOI":"10.1073\/pnas.1617669114","article-title":"Gfi1-Foxo1 axis controls the fidelity of effector gene expression and developmental maturation of thymocytes","volume":"114","author":"Shi","year":"2017","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.autrev.2025.103757_bb0535","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1002\/eji.200939567","article-title":"Early growth response 2 regulates the survival of thymocytes during positive selection","volume":"40","author":"Lawson","year":"2010","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0540","doi-asserted-by":"crossref","first-page":"4782","DOI":"10.4049\/jimmunol.1001179","article-title":"Histone deacetylase 7 regulates cell survival and TCR signaling in CD4\/CD8 double-positive thymocytes","volume":"186","author":"Kasler","year":"2011","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0545","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.3390\/biomedicines11102702","article-title":"Legend or truth: mature CD4+ CD8+ double-positive T cells in the periphery in health and disease","volume":"11","author":"Hagen","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.autrev.2025.103757_bb0550","doi-asserted-by":"crossref","first-page":"3488","DOI":"10.4049\/jimmunol.1700203","article-title":"Revisiting the road map of medullary thymic epithelial cell differentiation","volume":"199","author":"Michel","year":"2017","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0555","doi-asserted-by":"crossref","first-page":"5825","DOI":"10.4049\/jimmunol.1500082","article-title":"Thymic involution perturbs negative selection leading to autoreactive T cells that induce chronic inflammation","volume":"194","author":"Coder","year":"2015","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0560","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.140313","article-title":"Thymic rejuvenation via FOXN1-reprogrammed embryonic fibroblasts (FREFs) to counteract age-related inflammation","volume":"5","author":"Oh","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.autrev.2025.103757_bb0565","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1007\/s13238-013-3014-0","article-title":"Thymic epithelial cell development and differentiation: cellular and molecular regulation","volume":"4","author":"Sun","year":"2013","journal-title":"Prot Cell"},{"key":"10.1016\/j.autrev.2025.103757_bb0570","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3389\/fimmu.2011.00014","article-title":"Models of aire-dependent gene regulation for thymic negative selection","volume":"2","author":"Danso-Abeam","year":"2011","journal-title":"Front Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0575","doi-asserted-by":"crossref","first-page":"964","DOI":"10.3389\/fimmu.2018.00964","article-title":"Aire disruption influences the medullary thymic epithelial cell transcriptome and interaction with thymocytes","volume":"9","author":"Speck-Hernandez","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0580","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/imm.13099","article-title":"The autoimmune regulator (Aire) transactivates HLA-G gene expression in thymic epithelial cells","volume":"158","author":"Melo-Lima","year":"2019","journal-title":"Immunology"},{"key":"10.1016\/j.autrev.2025.103757_bb0585","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/s41467-017-00931-8","article-title":"NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection","volume":"8","author":"Wang","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.autrev.2025.103757_bb0590","doi-asserted-by":"crossref","first-page":"15928","DOI":"10.1038\/s41598-017-15918-0","article-title":"The corepressor NCOR1 regulates the survival of single-positive thymocytes","volume":"7","author":"M\u00fcller","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.autrev.2025.103757_bb0595","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.celrep.2016.03.048","article-title":"HDAC3 is a master regulator of mTEC development","volume":"15","author":"Goldfarb","year":"2016","journal-title":"Cell Rep"},{"key":"10.1016\/j.autrev.2025.103757_bb0600","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.71769","article-title":"Regulation of positive and negative selection and TCR signaling during thymic T cell development by capicua","volume":"10","author":"Kim","year":"2021","journal-title":"Elife"},{"key":"10.1016\/j.autrev.2025.103757_bb0605","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/intimm\/dxy082","article-title":"Plasma membrane sphingomyelin modulates thymocyte development by inhibiting TCR-induced apoptosis","volume":"31","author":"Toshima","year":"2019","journal-title":"Int Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0610","doi-asserted-by":"crossref","first-page":"5900","DOI":"10.1038\/s41598-020-62664-x","article-title":"Transcriptomic features of tumour-infiltrating CD4lowCD8high double positive \u03b1\u03b2 T cells in melanoma","volume":"10","author":"Parrot","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.autrev.2025.103757_bb0615","doi-asserted-by":"crossref","first-page":"3459","DOI":"10.3390\/cells10123459","article-title":"New insights into epigenetic regulation of T cell differentiation","volume":"10","author":"Dutta","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.autrev.2025.103757_bb0620","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.imlet.2017.02.012","article-title":"Understanding memory CD8+ T cells","volume":"185","author":"Samji","year":"2017","journal-title":"Immunol Lett"},{"key":"10.1016\/j.autrev.2025.103757_bb0625","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/cei.12345","article-title":"Analysis of CD4+ CD8+ double-positive T cells in blood, cerebrospinal fluid and multiple sclerosis lesions","volume":"177","author":"Waschbisch","year":"2014","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0630","first-page":"36","article-title":"Percentages of CD4+ CD8+ double-positive T lymphocytes in the peripheral blood of adults from a blood bank in Bogot\u00e1, Colombia","volume":"37","author":"Gonzalez-Mancera","year":"2020","journal-title":"Turkish J Hematol"},{"key":"10.1016\/j.autrev.2025.103757_bb0635","doi-asserted-by":"crossref","first-page":"613","DOI":"10.3389\/fimmu.2016.00613","article-title":"T cell trafficking through lymphatic vessels","volume":"7","author":"Hunter","year":"2016","journal-title":"Front Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0640","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1126\/science.aaf3892","article-title":"Tissue adaptation of regulatory and intraepithelial CD4+ T cells controls gut inflammation","volume":"352","author":"Sujino","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.autrev.2025.103757_bb0645","doi-asserted-by":"crossref","first-page":"8727","DOI":"10.1073\/pnas.0401500101","article-title":"CD4 on CD8+ T cells directly enhances effector function and is a target for HIV infection","volume":"101","author":"Kitchen","year":"2004","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.autrev.2025.103757_bb0650","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/ni.2523","article-title":"Transcriptional reprogramming of mature CD4+ helper T cells generates distinct MHC class II\u2013restricted cytotoxic T lymphocytes","volume":"14","author":"Mucida","year":"2013","journal-title":"Nat Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0655","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1182\/blood.V99.1.207","article-title":"Activation of CD8 T cells induces expression of CD4, which functions as a chemotactic receptor","volume":"99","author":"Kitchen","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.autrev.2025.103757_bb0660","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1182\/blood-2002-07-1972","article-title":"CD8+ T cells that express CD4 on their surface (CD4dimCD8bright T cells) recognize an antigen-specific target, are detected in vivo, and can be productively infected by T-tropic HIV","volume":"102","author":"Zloza","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.autrev.2025.103757_bb0665","doi-asserted-by":"crossref","first-page":"3794","DOI":"10.1073\/pnas.0406603102","article-title":"The CD4 molecule on CD8+ T lymphocytes directly enhances the immune response to viral and cellular antigens","volume":"102","author":"Kitchen","year":"2005","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.autrev.2025.103757_bb0670","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0067821","article-title":"In vitro induction of regulatory CD4+ CD8\u03b1+ T cells by TGF-\u03b2, IL-7 and IFN-\u03b3","volume":"8","author":"Van Kaer","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.autrev.2025.103757_bb0675","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0093293","article-title":"Peripheral CD4CD8 double positive T cells with a distinct helper cytokine profile are increased in rheumatoid arthritis","volume":"9","author":"Quandt","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.autrev.2025.103757_bb0680","doi-asserted-by":"crossref","first-page":"184","DOI":"10.4049\/jimmunol.1201163","article-title":"Isolation of human CD4\/CD8 double-positive, graft-versus-host disease\u2013protective, minor histocompatibility antigen\u2013specific regulatory T cells and of a novel HLA-DR7\u2013restricted HY-specific CD4 clone","volume":"190","author":"Eljaafari","year":"2013","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0685","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2021.111450","article-title":"Immunophenotypic characterization of double positive T lymphocytes in Cuban older adults","volume":"152","author":"Marrero","year":"2021","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.autrev.2025.103757_bb0690","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2022.895179","article-title":"The role of CD4+ CD8+ T cells in HIV infection with tuberculosis","volume":"10","author":"Zou","year":"2022","journal-title":"Front Public Health"},{"key":"10.1016\/j.autrev.2025.103757_bb0695","doi-asserted-by":"crossref","DOI":"10.4081\/mrm.2021.758","article-title":"Differential alterations in peripheral lymphocyte subsets in COVID-19 patients: upregulation of double-positive and double-negative T cells","volume":"16","author":"Zahran","year":"2021","journal-title":"Multidiscip Respir Med"},{"key":"10.1016\/j.autrev.2025.103757_bb0700","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0020145","article-title":"Distinct CD4+ CD8+ double-positive T cells in the blood and liver of patients during chronic hepatitis B and C","volume":"6","author":"Nascimbeni","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.autrev.2025.103757_bb0705","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001294","article-title":"Increased CD4+\/CD8+ double-positive T cells in chronic Chagasic patients","volume":"5","author":"Giraldo","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.autrev.2025.103757_bb0710","doi-asserted-by":"crossref","DOI":"10.1016\/j.clinbiochem.2023.110643","article-title":"Predictive value of CD4+ CD8+ double positive T cells for the severity of hemorrhagic fever with renal syndrome","volume":"120","author":"Zhao","year":"2023","journal-title":"Clin Biochem"},{"key":"10.1016\/j.autrev.2025.103757_bb0715","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3390\/v14010090","article-title":"A population of CD4+CD8+ double-positive T cells associated with risk of plasma leakage in dengue viral infection","volume":"14","author":"Yu","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.autrev.2025.103757_bb0720","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6658324","article-title":"Increased CD4+ CD8+ double-positive T cell in patients with primary Sj\u00f6gren\u2019s syndrome correlated with disease activity","volume":"2021","author":"Wang","year":"2021","journal-title":"J Immunol Res"},{"key":"10.1016\/j.autrev.2025.103757_bb0725","first-page":"1137","article-title":"Increased percentage of \"double phenotype\" form T lymphocytes in blood of patients with multiple sclerosis","volume":"34","author":"Ziaber","year":"2000","journal-title":"Neurol Neurochir Pol"},{"key":"10.1016\/j.autrev.2025.103757_bb0730","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1093\/rheumatology\/keab551","article-title":"Expansion of CD4+ CD8+ double-positive T cells in rheumatoid arthritis patients is associated with erosive disease","volume":"61","author":"Nguyen","year":"2022","journal-title":"Rheumatology"},{"key":"10.1016\/j.autrev.2025.103757_bb0735","doi-asserted-by":"crossref","first-page":"59","DOI":"10.7555\/JBR.36.20220094","article-title":"Peripheral CD4+ CD8+ double positive T cells: a potential marker to evaluate renal impairment susceptibility during systemic lupus erythematosus","volume":"37","author":"Chang","year":"2023","journal-title":"J Biomed Res"},{"key":"10.1016\/j.autrev.2025.103757_bb0740","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adf0567","article-title":"Inflammatory CD4\/CD8 double-positive human T cells arise from reactive CD8 T cells and are sufficient to mediate GVHD pathology","volume":"9","author":"Hess","year":"2023","journal-title":"Sci Adv"},{"key":"10.1016\/j.autrev.2025.103757_bb0745","doi-asserted-by":"crossref","first-page":"4331","DOI":"10.1182\/blood.V91.11.4331","article-title":"Isolation of tumor-specific cytotoxic CD4+ and CD4+ CD8dim+ T-cell clones infiltrating a cutaneous T-cell lymphoma","volume":"91","author":"Bagot","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.autrev.2025.103757_bb0750","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0008437","article-title":"Double positive CD4CD8 \u03b1\u03b2 T cells: a new tumor-reactive population in human melanomas","volume":"5","author":"Desfran\u00e7ois","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.autrev.2025.103757_bb0755","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/ijc.24366","article-title":"Increased frequency of nonconventional double positive CD4CD8 \u03b1\u03b2 T cells in human breast pleural effusions","volume":"125","author":"Desfran\u00e7ois","year":"2009","journal-title":"Int J Cancer"},{"key":"10.1016\/j.autrev.2025.103757_bb0760","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1080\/10428190802308728","article-title":"Beyond the lymphocyte predominant cell: CD4+ CD8+ T-cells in nodular lymphocyte predominant Hodgkin lymphoma","volume":"49","author":"Rahemtullah","year":"2008","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.autrev.2025.103757_bb0765","doi-asserted-by":"crossref","first-page":"718","DOI":"10.5858\/arpa.2020-0726-OA","article-title":"Flow cytometric detection of the double-positive (CD4+ CD8+)\/PD-1bright T-cell subset is useful in diagnosing nodular lymphocyte-predominant hodgkin lymphoma","volume":"146","author":"Chen","year":"2022","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.autrev.2025.103757_bb0770","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1002\/ijc.25640","article-title":"Tumor-reactive CD4+ CD8\u03b1\u03b2+ CD103+ \u03b1\u03b2T cells: a prevalent tumor-reactive T-cell subset in metastatic colorectal cancers","volume":"128","author":"Sarrabayrouse","year":"2011","journal-title":"Int J Cancer"},{"key":"10.1016\/j.autrev.2025.103757_bb0775","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1002\/1521-4141(200006)30:6<1733::AID-IMMU1733>3.0.CO;2-E","article-title":"A role for IL-5 in the induction of cytotoxic T lymphocytes in vivo","volume":"30","author":"Apostolopoulos","year":"2000","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.autrev.2025.103757_bb0780","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1084\/jem.20061120","article-title":"Breast cancer instructs dendritic cells to prime interleukin 13\u2013secreting CD4+ T cells that facilitate tumor development","volume":"204","author":"Aspord","year":"2007","journal-title":"J Exp Med"},{"key":"10.1016\/j.autrev.2025.103757_bb0785","doi-asserted-by":"crossref","first-page":"11743","DOI":"10.1158\/0008-5472.CAN-05-0045","article-title":"Interleukin-13\u2013regulated M2 macrophages in combination with myeloid suppressor cells block immune surveillance against metastasis","volume":"65","author":"Sinha","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.autrev.2025.103757_bb0790","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1016\/j.cell.2020.05.017","article-title":"Intratumoral CD4+ T cells mediate anti-tumor cytotoxicity in human bladder cancer","volume":"181","author":"Oh","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.autrev.2025.103757_bb0795","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20212169","article-title":"Tumor-induced double positive T cells display distinct lineage commitment mechanisms and functions","volume":"219","author":"Schad","year":"2022","journal-title":"J Exp Med"},{"key":"10.1016\/j.autrev.2025.103757_bb0800","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1084\/jem.20091279","article-title":"CD8+ T cell concentration determines their efficiency in killing cognate antigen\u2013expressing syngeneic mammalian cells in vitro and in mouse tissues","volume":"207","author":"Budhu","year":"2010","journal-title":"J Exp Med"},{"issue":"13_Supplement","key":"10.1016\/j.autrev.2025.103757_bb0805","doi-asserted-by":"crossref","DOI":"10.1158\/1538-7445.AM2021-487","article-title":"Genomic difference of CD4 CD8 double-positive T cells versus conventional CD4 T cells and CD8 T cells in responders undergoing immunotherapy in advanced HCC","volume":"81","author":"Ting","year":"2021","journal-title":"Cancer Res"},{"key":"10.1016\/j.autrev.2025.103757_bb0810","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13073-021-00861-7","article-title":"Development of double-positive thymocytes at single-cell resolution","volume":"13","author":"Li","year":"2021","journal-title":"Genome Med"},{"key":"10.1016\/j.autrev.2025.103757_bb0815","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12943-019-1085-0","article-title":"Regulatory T cells in tumor microenvironment: new mechanisms, potential therapeutic strategies and future prospects","volume":"19","author":"Li","year":"2020","journal-title":"Mol Cancer"},{"key":"10.1016\/j.autrev.2025.103757_bb0820","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s00262-011-1181-5","article-title":"Immune suppression in the tumor microenvironment: a role for dendritic cell-mediated tolerization of T cells","volume":"61","author":"Hurwitz","year":"2012","journal-title":"Cancer Immunol Immunother"},{"key":"10.1016\/j.autrev.2025.103757_bb0825","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.immuni.2022.12.008","article-title":"Microenvironment-driven metabolic adaptations guiding CD8+ T cell anti-tumor immunity","volume":"56","author":"Park","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.autrev.2025.103757_bb0830","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/j.it.2020.09.006","article-title":"The role of CD8 downregulation during thymocyte differentiation","volume":"41","author":"Nomura","year":"2020","journal-title":"Trends Immunol"}],"container-title":["Autoimmunity Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568997225000175?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568997225000175?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T20:35:03Z","timestamp":1740602103000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568997225000175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":166,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["S1568997225000175"],"URL":"https:\/\/doi.org\/10.1016\/j.autrev.2025.103757","relation":{},"ISSN":["1568-9972"],"issn-type":[{"value":"1568-9972","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CD4+CD8+ double-positive T cells in immune disorders and cancer: Prospects and hurdles in immunotherapy","name":"articletitle","label":"Article Title"},{"value":"Autoimmunity Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.autrev.2025.103757","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103757"}}