{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T23:06:08Z","timestamp":1782169568698,"version":"3.54.5"},"reference-count":41,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Autoimmunity Reviews"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.autrev.2025.103942","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T08:32:02Z","timestamp":1761121922000},"page":"103942","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["VE\/VCO2 at ventilatory threshold and peak VO2 in CPET studies of patients with scleroderma-associated PAH: A systematic review and meta-analyses"],"prefix":"10.1016","volume":"25","author":[{"given":"Julie","family":"Better","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Leroy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten K.","family":"Ninaber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Trakada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilge","family":"Kesikburun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Rosenkranz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Ewert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Habedank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Dumitrescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanis","family":"Kouchit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nihal","family":"Martis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.autrev.2025.103942_bb0005","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S1568-9972(03)00004-1","article-title":"New insights into the pathogenesis of systemic sclerosis","volume":"2","author":"Tamby","year":"2003","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.autrev.2025.103942_bb0010","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1093\/rheumatology\/ker269","article-title":"Trends in mortality in patients with systemic sclerosis over 40 years: a systematic review and meta-analysis of cohort studies","volume":"51","author":"Elhai","year":"2012","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.autrev.2025.103942_bb0015","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.autrev.2016.07.025","article-title":"Pulmonary involvement in systemic sclerosis","volume":"15","author":"Morales-C\u00e1rdenas","year":"2016","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.autrev.2025.103942_bb0020","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1002\/art.30423","article-title":"Systemic sclerosis\u2013related pulmonary hypertension associated with interstitial lung disease: impact of pulmonary arterial hypertension therapies","volume":"63","author":"Le Pavec","year":"2011","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.autrev.2025.103942_bb0025","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s11926-015-0560-x","article-title":"Current approaches to the treatment of systemic-sclerosis-associated pulmonary arterial hypertension (SSc-PAH)","volume":"18","author":"Sobanski","year":"2016","journal-title":"Curr Rheumatol Rep"},{"key":"10.1016\/j.autrev.2025.103942_bb0030","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1164\/rccm.167.2.211","article-title":"American College of Chest Physicians. ATS\/ACCP statement on cardiopulmonary exercise testing","volume":"167","author":"American Thoracic Society","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.autrev.2025.103942_bb0035","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3899\/jrheum.161349","article-title":"Limited exercise capacity in patients with systemic sclerosis: identifying contributing factors with cardiopulmonary exercise testing","volume":"45","author":"Martis","year":"2018","journal-title":"J Rheumatol"},{"key":"10.1016\/j.autrev.2025.103942_bb0040","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1186\/s12890-019-1003-7","article-title":"Prognostic value of cardiopulmonary exercise testing in patients with systemic sclerosis","volume":"19","author":"Ewert","year":"2019","journal-title":"BMC Pulm Med"},{"key":"10.1016\/j.autrev.2025.103942_bb0045","first-page":"774","article-title":"Cardiopulmonary exercise testing for detecting pulmonary arterial hypertension in systemic sclerosis","volume":"103","author":"Dumitrescu","year":"2017","journal-title":"Heart Br Card Soc"},{"key":"10.1016\/j.autrev.2025.103942_bb0050","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1093\/rheumatology\/kez473","article-title":"Cardiopulmonary exercise testing in a combined screening approach to individuate pulmonary arterial hypertension in systemic sclerosis","volume":"59","author":"Santaniello","year":"2020","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.autrev.2025.103942_bb0055","first-page":"115","article-title":"Phenotyping exercise limitation in systemic sclerosis: the use of cardiopulmonary exercise testing","volume":"91","author":"Boutou","year":"2016","journal-title":"Respir Int Rev Thorac Dis"},{"key":"10.1016\/j.autrev.2025.103942_bb0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0014293","article-title":"Developing pulmonary vasculopathy in systemic sclerosis, detected with non-invasive cardiopulmonary exercise testing","volume":"5","author":"Dumitrescu","year":"2010","journal-title":"PloS One"},{"key":"10.1016\/j.autrev.2025.103942_bb0065","first-page":"342","article-title":"Cardiopulmonary exercise testing is an accurate tool for the diagnosis of pulmonary arterial hypertension in scleroderma related diseases","volume":"14","author":"Bellan","year":"2021","journal-title":"Pharm Basel Switz"},{"key":"10.1016\/j.autrev.2025.103942_bb0070","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1093\/eurheartj\/ehac237","volume":"43","author":"Humbert","year":"2022","journal-title":"Eur Heart J"},{"key":"10.1016\/j.autrev.2025.103942_bb0075","first-page":"50","article-title":"Changes in pulmonary exercise haemodynamics in scleroderma: a 4-year prospective study","author":"Kovacs","year":"2017","journal-title":"Eur Respir J"},{"key":"10.1016\/j.autrev.2025.103942_bb0080","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1136\/annrheumdis-2013-203301","article-title":"Evidence-based detection of pulmonary arterial hypertension in systemic sclerosis: the DETECT study","volume":"73","author":"Coghlan","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2025.103942_bb0085","doi-asserted-by":"crossref","first-page":"330","DOI":"10.3109\/03009740903555358","article-title":"Impaired exercise performance in systemic sclerosis and its clinical correlations","volume":"39","author":"Cuomo","year":"2010","journal-title":"Scand J Rheumatol"},{"key":"10.1016\/j.autrev.2025.103942_bb0090","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1080\/03009740701605889","article-title":"Reduced exercise capacity in systemic sclerosis patients without pulmonary involvement","volume":"36","author":"de Oliveira","year":"2007","journal-title":"Scand J Rheumatol"},{"key":"10.1016\/j.autrev.2025.103942_bb0095","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s00296-021-04937-w","article-title":"Cardiopulmonary exercise testing and prognosis in patients with systemic sclerosis without baseline pulmonary hypertension: a prospective cohort study","volume":"42","author":"Bournia","year":"2022","journal-title":"Rheumatol Int"},{"issue":"Suppl. 131","key":"10.1016\/j.autrev.2025.103942_bb0100","doi-asserted-by":"crossref","first-page":"94","DOI":"10.55563\/clinexprheumatol\/tktu8v","article-title":"Evaluation of cardiopulmonary exercise test in the prediction of disease progression in systemic sclerosis","volume":"39","author":"Hemelein","year":"2021","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.autrev.2025.103942_bb0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2046-4053-4-1","article-title":"Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement","volume":"4","author":"Moher","year":"2015","journal-title":"Syst Rev"},{"key":"10.1016\/j.autrev.2025.103942_bb0110","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/eurheartj\/ehv317","article-title":"2015 ESC\/ERS guidelines for the diagnosis and treatment of pulmonary hypertension","volume":"37","author":"Gali\u00e8","year":"2016","journal-title":"Eur Heart J"},{"key":"10.1016\/j.autrev.2025.103942_bb0115","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1164\/rccm.2202033","article-title":"Ventilatory efficiency during exercise in healthy subjects","volume":"166","author":"Sun","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.autrev.2025.103942_bb0120","author":"Ottawa Hospital Research Institute"},{"key":"10.1016\/j.autrev.2025.103942_bb0125","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/1471-2288-14-135","article-title":"Estimating the sample mean and standard deviation from the sample size, median, range and\/or interquartile range","volume":"14","author":"Wan","year":"2014","journal-title":"BMC Med Res Methodol"},{"key":"10.1016\/j.autrev.2025.103942_bb0130","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.jclinepi.2006.11.003","article-title":"Effect sizes can be calculated for studies reporting ranges for outcome variables in systematic reviews","volume":"60","author":"Walter","year":"2007","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.autrev.2025.103942_bb0135","first-page":"4","article-title":"Cardiopulmonary functions and aerobic capacity in patients with systemic sclerosis","author":"Kesikburun","year":"2019","journal-title":"CYPRUS J Med Sci"},{"key":"10.1016\/j.autrev.2025.103942_bb0140","article-title":"Detection of pulmonary vasculopathy by novel analysis of oxygen uptake in patients with systemic sclerosis: association with pulmonary arterial pressures","volume":"32","author":"Ninaber","year":"2014","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.autrev.2025.103942_bb0145","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1164\/rccm.200904-0563OC","article-title":"Borderline pulmonary arterial pressure is associated with decreased exercise capacity in scleroderma","volume":"180","author":"Kovacs","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.autrev.2025.103942_bb0150","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/0002-9343(93)90311-C","article-title":"Failure of the circulatory system limits exercise performance in patients with systemic sclerosis","volume":"95","author":"Sudduth","year":"1993","journal-title":"Am J Med"},{"key":"10.1016\/j.autrev.2025.103942_bb0155","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.3899\/jrheum.091424","article-title":"Cardiopulmonary exercise testing with right-heart catheterization in patients with systemic sclerosis","volume":"37","author":"Walkey","year":"2010","journal-title":"J Rheumatol"},{"key":"10.1016\/j.autrev.2025.103942_bb0160","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1161\/CIR.0b013e31826fb946","article-title":"Clinical recommendations for cardiopulmonary exercise testing data assessment in specific patient populations","volume":"126","author":"Guazzi","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.autrev.2025.103942_bb0165","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1186\/s13075-014-0493-1","article-title":"Borderline pulmonary arterial pressure in systemic sclerosis patients: a post-hoc analysis of the DETECT study","volume":"16","author":"Visovatti","year":"2014","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.autrev.2025.103942_bb0170","first-page":"51","article-title":"Incidence of pulmonary hypertension and determining factors in patients with systemic sclerosis","author":"Coghlan","year":"2018","journal-title":"Eur Respir J"},{"key":"10.1016\/j.autrev.2025.103942_bb0175","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1136\/annrheumdis-2012-202567","article-title":"Expert consensus for performing right heart catheterisation for suspected pulmonary arterial hypertension in systemic sclerosis: a Delphi consensus study with cluster analysis","volume":"73","author":"Avouac","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2025.103942_bb0180","doi-asserted-by":"crossref","first-page":"3792","DOI":"10.1002\/art.21433","article-title":"Early detection of pulmonary arterial hypertension in systemic sclerosis: a French nationwide prospective multicenter study","volume":"52","author":"Hachulla","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.autrev.2025.103942_bb0185","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.revmed.2022.05.005","article-title":"La place de l\u2019Exploration Fonctionnelle (cardio-)respiratoire d\u2019eXercice (EFX) dans la prise en charge de la scl\u00e9rodermie syst\u00e9mique","volume":"43","author":"Martis","year":"2022","journal-title":"Rev M\u00e9decine Interne"},{"key":"10.1016\/j.autrev.2025.103942_bb0190","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1378\/chest.110.6.1520","article-title":"Cardiorespiratory responses to incremental exercise in patients with systemic sclerosis","volume":"110","author":"Schwaiblmair","year":"1996","journal-title":"Chest"},{"key":"10.1016\/j.autrev.2025.103942_bb0195","first-page":"67","article-title":"Cardiopulmonary exercise testing in patients with systemic sclerosis: unexplored mechanisms of dyspnea [abstract]","author":"Schoenfeld","year":"2015","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.autrev.2025.103942_bb0200","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/S0140-6736(17)30933-9","article-title":"Systemic sclerosis","volume":"390","author":"Denton","year":"2017","journal-title":"Lancet Lond Engl"},{"key":"10.1016\/j.autrev.2025.103942_bb0205","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1080\/030097400750041389","article-title":"Pulmonary hypertension is associated with impaired exercise performance in patients with systemic sclerosis","volume":"29","author":"Morelli","year":"2000","journal-title":"Scand J Rheumatol"}],"container-title":["Autoimmunity Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568997225002034?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568997225002034?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T13:09:15Z","timestamp":1767100155000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568997225002034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S1568997225002034"],"URL":"https:\/\/doi.org\/10.1016\/j.autrev.2025.103942","relation":{},"ISSN":["1568-9972"],"issn-type":[{"value":"1568-9972","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"VE\/VCO2 at ventilatory threshold and peak VO2 in CPET studies of patients with scleroderma-associated PAH: A systematic review and meta-analyses","name":"articletitle","label":"Article Title"},{"value":"Autoimmunity Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.autrev.2025.103942","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103942"}}