{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T12:13:42Z","timestamp":1788178422999,"version":"build-2803163510"},"reference-count":145,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005269","name":"Provincial Foundation for Excellent Young Talents of Colleges and Universities of Anhui Province","doi-asserted-by":"publisher","award":["2023AH030120"],"award-info":[{"award-number":["2023AH030120"]}],"id":[{"id":"10.13039\/501100005269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Autoimmunity Reviews"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.autrev.2026.104004","type":"journal-article","created":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T22:55:25Z","timestamp":1770591325000},"page":"104004","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Regulatory mechanisms and targeted therapeutic strategies of glycolytic metabolism in rheumatoid arthritis"],"prefix":"10.1016","volume":"25","author":[{"given":"Miao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongsheng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Feng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10055","key":"10.1016\/j.autrev.2026.104004_bb0005","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/S0140-6736(16)30173-8","article-title":"Rheumatoid arthritis","volume":"388","author":"Smolen","year":"2016","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.autrev.2026.104004_bb0010","article-title":"Global trends in research of gouty arthritis over past decade: a bibliometric analysis","volume":"13","author":"Deng","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.autrev.2026.104004_bb0015","doi-asserted-by":"crossref","first-page":"1440398","DOI":"10.3389\/fimmu.2024.1440398","article-title":"YTHDC1 regulates the migration, invasion, proliferation, and apoptosis of rheumatoid fibroblast-like Synoviocytes","volume":"15","author":"Feng","year":"2024","journal-title":"Front Immunol"},{"key":"10.1016\/j.autrev.2026.104004_bb0020","doi-asserted-by":"crossref","first-page":"1556971","DOI":"10.3389\/fimmu.2025.1556971","article-title":"From genetic variants to therapeutic targets: insights into understanding rheumatoid arthritis","volume":"16","author":"Chen","year":"2025","journal-title":"Front Immunol"},{"key":"10.1016\/j.autrev.2026.104004_bb0025","doi-asserted-by":"crossref","first-page":"1167362","DOI":"10.3389\/fimmu.2024.1167362","article-title":"Macrophage extracellular traps require peptidylarginine deiminase 2 and 4 and are a source of citrullinated antigens bound by rheumatoid arthritis autoantibodies","volume":"15","author":"Bashar","year":"2024","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.autrev.2026.104004_bb0030","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1093\/jleuko\/qiad102","article-title":"Macrophage extracellular traps promote tumor-like biologic behaviors of fibroblast-like synoviocytes through cGAS-mediated PI3K\/Akt signaling pathway in patients with rheumatoid arthritis","volume":"115","author":"Weng","year":"2024","journal-title":"J Leukoc Biol"},{"issue":"7987","key":"10.1016\/j.autrev.2026.104004_bb0035","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/s41586-023-06708-y","article-title":"Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes","volume":"623","author":"Zhang","year":"2023","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.autrev.2026.104004_bb0040","doi-asserted-by":"crossref","first-page":"e743","DOI":"10.1016\/S2665-9913(23)00242-4","article-title":"Autoantibody-negative rheumatoid arthritis: still a challenge for the rheumatologist","volume":"5","author":"Bugatti","year":"2023","journal-title":"Lancet Rheumatol"},{"key":"10.1016\/j.autrev.2026.104004_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2023.103001","article-title":"Gut microbiota in pre-clinical rheumatoid arthritis: from pathogenesis to preventing progression","volume":"141","author":"Lin","year":"2023","journal-title":"J Autoimmun"},{"issue":"10","key":"10.1016\/j.autrev.2026.104004_bb0050","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/s41584-024-01154-0","article-title":"Distinct mucosal endotypes as initiators and drivers of rheumatoid arthritis","volume":"20","author":"Holers","year":"2024","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.autrev.2026.104004_bb0055","article-title":"Treatment with FAP-targeted zinc ferrite nanoparticles for rheumatoid arthritis by inducing endoplasmic reticulum stress and mitochondrial damage","volume":"21","author":"Qi","year":"2023","journal-title":"Mater Today Bio"},{"key":"10.1016\/j.autrev.2026.104004_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113687","article-title":"Secretory phosphoprotein 1 secreted by fibroblast-like synoviocytes promotes osteoclasts formation via PI3K\/AKT signaling in collagen-induced arthritis","volume":"155","author":"Cai","year":"2022","journal-title":"Biomed Pharmacother"},{"issue":"8","key":"10.1016\/j.autrev.2026.104004_bb0065","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1136\/annrheumdis-2021-222021","article-title":"Synovial fibroblasts as potential drug targets in rheumatoid arthritis, where do we stand and where shall we go?","volume":"81","author":"N\u00e9meth","year":"2022","journal-title":"Ann Rheum Dis"},{"issue":"9","key":"10.1016\/j.autrev.2026.104004_bb0070","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1136\/ard-2022-223396","article-title":"Cytokine-directed cellular cross-talk imprints synovial pathotypes in rheumatoid arthritis","volume":"82","author":"Kugler","year":"2023","journal-title":"Ann Rheum Dis"},{"issue":"Pt 2","key":"10.1016\/j.autrev.2026.104004_bb0075","article-title":"Targeting IL-17 and its receptors: a feasible way for natural herbal medicines to modulate fibroblast-like synoviocytes in rheumatoid arthritis","volume":"230","author":"Liang","year":"2024","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.autrev.2026.104004_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122390","article-title":"Pathophysiology to advanced intra-articular drug delivery strategies: unravelling rheumatoid arthritis","volume":"303","author":"Singh","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.autrev.2026.104004_bb0085","doi-asserted-by":"crossref","first-page":"1051082","DOI":"10.3389\/fimmu.2022.1051082","article-title":"Systemic complications of rheumatoid arthritis: focus on pathogenesis and treatment","volume":"13","author":"Wu","year":"2022","journal-title":"Front Immunol"},{"issue":"2","key":"10.1016\/j.autrev.2026.104004_bb0090","first-page":"119","article-title":"Reexamining cancer metabolism: lactate production for carcinogenesis could be the purpose and explanation of the Warburg effect","volume":"38","author":"San-Mill\u00e1n","year":"2017","journal-title":"Carcinogenesis"},{"issue":"10","key":"10.1016\/j.autrev.2026.104004_bb0095","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/nrc.2016.77","article-title":"Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy?","volume":"16","author":"Hay","year":"2016","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.autrev.2026.104004_bb0100","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev-cellbio-092910-154237","article-title":"Aerobic glycolysis: meeting the metabolic requirements of cell proliferation","volume":"27","author":"Lunt","year":"2011","journal-title":"Annu Rev Cell Dev Biol"},{"key":"10.1016\/j.autrev.2026.104004_bb0105","doi-asserted-by":"crossref","first-page":"1264083","DOI":"10.3389\/fonc.2023.1264083","article-title":"Knowledge mapping and current trends of Warburg effect in the field of cancer","volume":"13","author":"Zhao","year":"2023","journal-title":"Front Oncol"},{"issue":"3","key":"10.1016\/j.autrev.2026.104004_bb0110","doi-asserted-by":"crossref","first-page":"705","DOI":"10.34172\/apb.2024.049","article-title":"Exploring the interplay between the Warburg effect and glucolipotoxicity in cancer development: a novel perspective on cancer Etiology","volume":"14","author":"Akl","year":"2024","journal-title":"Adv Pharmaceut Bull"},{"key":"10.1016\/j.autrev.2026.104004_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.111257","article-title":"NMAAP1 regulated macrophage polarizion into M1 type through glycolysis stimulated with BCG","volume":"126","author":"Mi","year":"2024","journal-title":"Int Immunopharmacol"},{"issue":"7","key":"10.1016\/j.autrev.2026.104004_bb0120","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/s41419-023-05937-3","article-title":"Effects of altered glycolysis levels on CD8(+) T cell activation and function","volume":"14","author":"Cao","year":"2023","journal-title":"Cell Death Dis"},{"issue":"5","key":"10.1016\/j.autrev.2026.104004_bb0125","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1369\/00221554241249515","article-title":"New insights in ATP synthesis as therapeutic target in cancer and Angiogenic ocular diseases","volume":"72","author":"van Noorden","year":"2024","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.autrev.2026.104004_bb0130","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.808859","article-title":"Tumor-derived lactate creates a Favorable niche for tumor via supplying energy source for tumor and modulating the tumor microenvironment","volume":"10","author":"Jin","year":"2022","journal-title":"Front Cell Dev Biol"},{"issue":"1","key":"10.1016\/j.autrev.2026.104004_bb0135","doi-asserted-by":"crossref","first-page":"10176","DOI":"10.1038\/s41598-024-60962-2","article-title":"Follicle-stimulating hormone receptor expression in advanced atherosclerotic plaques","volume":"14","author":"Ghinea","year":"2024","journal-title":"Sci Rep"},{"issue":"10\u221212","key":"10.1016\/j.autrev.2026.104004_bb0140","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1089\/ars.2022.0180","article-title":"Redox regulation of nucleotide-binding and oligomerization domain-like receptors Inflammasome","volume":"39","author":"Ferrara","year":"2023","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.autrev.2026.104004_bb0145","doi-asserted-by":"crossref","first-page":"637","DOI":"10.2147\/JIR.S503118","article-title":"Deciphering Immunometabolic landscape in rheumatoid arthritis: integrative multiomics, explainable machine learning and experimental validation","volume":"18","author":"Dong","year":"2025","journal-title":"J Inflamm Res"},{"key":"10.1016\/j.autrev.2026.104004_bb0150","doi-asserted-by":"crossref","first-page":"347","DOI":"10.3389\/fphys.2020.00347","article-title":"Metabolic checkpoints in rheumatoid arthritis","volume":"11","author":"Pucino","year":"2020","journal-title":"Front Physiol"},{"issue":"1","key":"10.1016\/j.autrev.2026.104004_bb0155","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/s42003-025-08130-8","article-title":"Mannose inhibits PKM2 lactylation to induce pyroptosis in bladder cancer and activate antitumor immune responses","volume":"8","author":"Jin","year":"2025","journal-title":"Commun Biol"},{"key":"10.1016\/j.autrev.2026.104004_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122760","article-title":"Inflammatory stimulus-responsive polymersomes reprogramming glucose metabolism mitigates rheumatoid arthritis","volume":"312","author":"Wang","year":"2025","journal-title":"Biomaterials"},{"issue":"8","key":"10.1016\/j.autrev.2026.104004_bb0165","article-title":"Docking and molecular dynamics study to identify novel phytobiologics from Dracaena trifasciata against metabolic reprogramming in rheumatoid arthritis","volume":"12","author":"Ahmed","year":"2022","journal-title":"Life (Basel, Switzerland)"},{"issue":"1","key":"10.1016\/j.autrev.2026.104004_bb0170","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s13020-023-00833-6","article-title":"Coix seed oil alleviates synovial angiogenesis through suppressing HIF-1\u03b1\/VEGF-A signaling pathways via SIRT1 in collagen-induced arthritis rats","volume":"18","author":"Xu","year":"2023","journal-title":"Chinas Med"},{"issue":"3","key":"10.1016\/j.autrev.2026.104004_bb0175","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/s41419-022-04647-6","article-title":"Extracellular ATP promotes breast cancer chemoresistance via HIF-1\u03b1 signaling","volume":"13","author":"Yang","year":"2022","journal-title":"Cell Death Dis"},{"issue":"1","key":"10.1016\/j.autrev.2026.104004_bb0180","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1186\/s12967-024-05753-z","article-title":"GLP-1R activation attenuates the progression of pulmonary fibrosis via disrupting NLRP3 inflammasome\/PFKFB3-driven glycolysis interaction and histone lactylation","volume":"22","author":"Liu","year":"2024","journal-title":"J Transl Med"},{"issue":"1","key":"10.1016\/j.autrev.2026.104004_bb0185","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s43556-023-00161-z","article-title":"The disruptor of telomeric silencing 1-like (DOT1L) promotes peritoneal fibrosis through the upregulation and activation of protein tyrosine kinases","volume":"5","author":"Tao","year":"2024","journal-title":"Mol Biomed"},{"issue":"5","key":"10.1016\/j.autrev.2026.104004_bb0190","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1007\/s00011-023-01728-w","article-title":"Resveratrol-induced SIRT1 activation inhibits glycolysis-fueled angiogenesis under rheumatoid arthritis conditions independent of HIF-1\u03b1","volume":"72","author":"Jiang","year":"2023","journal-title":"Inflamm Res"},{"issue":"1","key":"10.1016\/j.autrev.2026.104004_bb0195","doi-asserted-by":"crossref","DOI":"10.2478\/aite-2024-0014","article-title":"Solute carrier transporters in synovial membrane and Hoffa\u2019s pad of patients with rheumatoid arthritis","volume":"72","author":"Malinowski","year":"2024","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"issue":"12","key":"10.1016\/j.autrev.2026.104004_bb0200","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1007\/s00011-023-01807-y","article-title":"Targeting glycolytic pathway in fibroblast-like synoviocytes for rheumatoid arthritis therapy: challenges and opportunities","volume":"72","author":"Li","year":"2023","journal-title":"Inflamm Res"},{"key":"10.1016\/j.autrev.2026.104004_bb0205","doi-asserted-by":"crossref","first-page":"1403823","DOI":"10.3389\/fphar.2024.1403823","article-title":"Targeting dysregulated intracellular immunometabolism within synovial microenvironment in rheumatoid arthritis with natural products","volume":"15","author":"Hu","year":"2024","journal-title":"Front Pharmacol"},{"issue":"9","key":"10.1016\/j.autrev.2026.104004_bb0210","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1016\/j.drudis.2022.05.017","article-title":"The development of small-molecule inhibitors targeting hexokinase 2","volume":"27","author":"Shan","year":"2022","journal-title":"Drug Discov Today"},{"issue":"1","key":"10.1016\/j.autrev.2026.104004_bb0215","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/s41420-023-01412-2","article-title":"Let-7b-5p inhibits breast cancer cell growth and metastasis via repression of hexokinase 2-mediated aerobic glycolysis","volume":"9","author":"Li","year":"2023","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.autrev.2026.104004_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109556","article-title":"Hexokinase inhibitor 2-deoxyglucose coordinates citrullination of vimentin and apoptosis of fibroblast-like synoviocytes by inhibiting HK2 \/mTORC1-induced autophagy","volume":"114","author":"Xian","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.autrev.2026.104004_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115986","article-title":"Research progress of hexokinase 2 in inflammatory-related diseases and its inhibitors","volume":"264","author":"Chen","year":"2024","journal-title":"Eur J Med Chem"},{"issue":"1","key":"10.1016\/j.autrev.2026.104004_bb0230","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/s12964-022-00943-y","article-title":"HK2: a potential regulator of osteoarthritis via glycolytic and non-glycolytic pathways","volume":"20","author":"Bao","year":"2022","journal-title":"Cell Commun Signal"},{"key":"10.1016\/j.autrev.2026.104004_bb0235","doi-asserted-by":"crossref","first-page":"1103231","DOI":"10.3389\/fimmu.2023.1103231","article-title":"Role of mitochondria-bound HK2 in rheumatoid arthritis fibroblast-like synoviocytes","volume":"14","author":"Torres","year":"2023","journal-title":"Front Immunol"},{"issue":"9","key":"10.1016\/j.autrev.2026.104004_bb0240","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1007\/s00535-023-02012-8","article-title":"Dual FGFR and VEGFR inhibition synergistically restrain hexokinase 2-dependent lymphangiogenesis and immune escape in intrahepatic cholangiocarcinoma","volume":"58","author":"Peng","year":"2023","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.autrev.2026.104004_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2023.113668","article-title":"Carrier-free nanodrug targeting glucose metabolism for enhanced rheumatoid arthritis treatment","volume":"233","author":"Chen","year":"2024","journal-title":"Colloids Surf B Biointerfaces"},{"issue":"6","key":"10.1016\/j.autrev.2026.104004_bb0250","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1111\/cas.15763","article-title":"Trigred motif 36 regulates neuroendocrine differentiation of prostate cancer via HK2 ubiquitination and GPx4 deficiency","volume":"114","author":"Zhao","year":"2023","journal-title":"Cancer Sci"},{"issue":"11","key":"10.1016\/j.autrev.2026.104004_bb0255","doi-asserted-by":"crossref","first-page":"3576","DOI":"10.7150\/ijbs.85133","article-title":"Purinergic receptor P2Y12 boosts autoimmune hepatitis through hexokinase 2-dependent glycolysis in T cells","volume":"19","author":"Zhuang","year":"2023","journal-title":"Int J Biol Sci"},{"issue":"13","key":"10.1016\/j.autrev.2026.104004_bb0260","doi-asserted-by":"crossref","first-page":"3434","DOI":"10.7150\/jca.77619","article-title":"Clinical implications of the interaction between PD-1\/PD-L1 and PI3K\/AKT\/mTOR pathway in progression and treatment of non-small cell lung cancer","volume":"13","author":"Quan","year":"2022","journal-title":"J Cancer"},{"issue":"39","key":"10.1016\/j.autrev.2026.104004_bb0265","first-page":"e2402115","article-title":"GJB2 promotes HCC progression by activating glycolysis through cytoplasmic translocation and generating a suppressive tumor microenvironment based on single cell RNA sequencing","volume":"11","author":"Liu","year":"2024","journal-title":"Adv. Sci. Weinheim, Baden-Wurttemberg, Germany"},{"issue":"1","key":"10.1016\/j.autrev.2026.104004_bb0270","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1186\/s13075-023-03161-0","article-title":"Dual inhibition of glycolysis and glutaminolysis for synergistic therapy of rheumatoid arthritis","volume":"25","author":"Ahmed","year":"2023","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.autrev.2026.104004_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114102","article-title":"PFKFB3 decreases \u03b1-ketoglutarate production while partial PFKFB3 knockdown in macrophages ameliorates arthritis in tumor necrosis factor-transgenic mice","volume":"148","author":"Zhu","year":"2025","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.autrev.2026.104004_bb0280","doi-asserted-by":"crossref","first-page":"1394108","DOI":"10.3389\/fimmu.2024.1394108","article-title":"Macrophage polarization in rheumatoid arthritis: signaling pathways, metabolic reprogramming, and crosstalk with synovial fibroblasts","volume":"15","author":"Zheng","year":"2024","journal-title":"Front Immunol"},{"issue":"2","key":"10.1016\/j.autrev.2026.104004_bb0285","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1093\/cei\/uxab021","article-title":"Metabolites as drivers and targets in rheumatoid arthritis","volume":"208","author":"Hanlon","year":"2022","journal-title":"Clin Exp Immunol"},{"issue":"7","key":"10.1016\/j.autrev.2026.104004_bb0290","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/s12276-023-01020-1","article-title":"Metabolic reprogramming and epigenetic modifications in cancer: from the impacts and mechanisms to the treatment potential","volume":"55","author":"Xu","year":"2023","journal-title":"Exp Mol Med"},{"issue":"11","key":"10.1016\/j.autrev.2026.104004_bb0295","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14112655","article-title":"Crosstalk of epigenetic and metabolic Signaling underpinning glioblastoma pathogenesis","volume":"14","author":"Markouli","year":"2022","journal-title":"Cancers"},{"issue":"20","key":"10.1016\/j.autrev.2026.104004_bb0300","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1161\/CIRCULATIONAHA.123.065880","article-title":"Metabolic reprogramming: a Byproduct or a driver of cardiomyocyte proliferation?","volume":"149","author":"Chen","year":"2024","journal-title":"Circulation"},{"issue":"12","key":"10.1016\/j.autrev.2026.104004_bb0305","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1038\/s41401-024-01389-3","article-title":"SGLT2 inhibitors ameliorate NAFLD in mice via downregulating PFKFB3, suppressing glycolysis and modulating macrophage polarization","volume":"45","author":"Lin","year":"2024","journal-title":"Acta Pharmacol Sin"},{"issue":"51","key":"10.1016\/j.autrev.2026.104004_bb0310","article-title":"Metabolic homeostasis-regulated nanoparticles for antibody-independent cancer radio-immunotherapy","volume":"34","author":"Shen","year":"2022","journal-title":"Adv Mater (Deerfield Beach, Fla)"},{"key":"10.1016\/j.autrev.2026.104004_bb0315","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.2147\/JIR.S398291","article-title":"The involvement of glucose and lipid metabolism alteration in rheumatoid arthritis and its clinical implication","volume":"16","author":"Luo","year":"2023","journal-title":"J Inflamm Res"},{"issue":"5","key":"10.1016\/j.autrev.2026.104004_bb0320","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1002\/ptr.7712","article-title":"Sarsasapogenin, a principal active component absorbed into blood of total saponins of Anemarrhena, attenuates proliferation and invasion in rheumatoid arthritis fibroblast-like synoviocytes through downregulating PKM2 inhibited pathological glycolysis","volume":"37","author":"Dai","year":"2023","journal-title":"Phytother Res"},{"issue":"10","key":"10.1016\/j.autrev.2026.104004_bb0325","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1080\/13543776.2024.2403616","article-title":"Pyruvate kinase modulators as a therapy target: an updated patent review 2018-2023","volume":"34","author":"Adem","year":"2024","journal-title":"Expert Opin Ther Pat"},{"issue":"Pt B","key":"10.1016\/j.autrev.2026.104004_bb0330","article-title":"Knowledge-driven design and optimization of potent symmetric anticancer molecules: a case study on PKM2 activators","volume":"151","author":"Jaiswal","year":"2022","journal-title":"Comput Biol Med"},{"key":"10.1016\/j.autrev.2026.104004_bb0335","doi-asserted-by":"crossref","first-page":"1017650","DOI":"10.3389\/fmed.2022.1017650","article-title":"Rheumatoid arthritis and mitochondrial homeostasis: the crossroads of metabolism and immunity","volume":"9","author":"Cui","year":"2022","journal-title":"Front Med"},{"issue":"833","key":"10.1016\/j.autrev.2026.104004_bb0340","doi-asserted-by":"crossref","first-page":"eadg5678","DOI":"10.1126\/scisignal.adg5678","article-title":"TNF-\u03b1 signals through ITK-Akt-mTOR to drive CD4(+) T cell metabolic reprogramming, which is dysregulated in rheumatoid arthritis","volume":"17","author":"Bishop","year":"2024","journal-title":"Sci Signal"},{"key":"10.1016\/j.autrev.2026.104004_bb0345","doi-asserted-by":"crossref","first-page":"1327852","DOI":"10.3389\/fimmu.2023.1327852","article-title":"Glycolysis: an emerging regulator of osteoarthritis","volume":"14","author":"Jiang","year":"2023","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.autrev.2026.104004_bb0350","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s40170-025-00387-1","article-title":"ETV4\/ALYREF-mediated glycolytic metabolism through PKM2 enhances resistance to ferroptosis and promotes the development of intrahepatic cholangiocarcinoma","volume":"13","author":"Wang","year":"2025","journal-title":"Cancer Metab"},{"issue":"1","key":"10.1016\/j.autrev.2026.104004_bb0355","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1186\/s12967-023-04658-7","article-title":"Transcription factor LHX9 (LIM Homeobox 9) enhances pyruvate kinase PKM2 activity to induce glycolytic metabolic reprogramming in cancer stem cells, promoting gastric cancer progression","volume":"21","author":"Zhao","year":"2023","journal-title":"J Transl Med"},{"issue":"6","key":"10.1016\/j.autrev.2026.104004_bb0360","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1080\/08923973.2022.2086139","article-title":"Triptolide inhibits Th17 differentiation via controlling PKM2-mediated glycolysis in rheumatoid arthritis","volume":"44","author":"Shen","year":"2022","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"10.1016\/j.autrev.2026.104004_bb0365","doi-asserted-by":"crossref","first-page":"4196","DOI":"10.1016\/j.csbj.2023.08.015","article-title":"Hybrid computational modeling highlights reverse Warburg effect in breast cancer-associated fibroblasts","volume":"21","author":"Aghakhani","year":"2023","journal-title":"Comput Struct Biotechnol J"},{"key":"10.1016\/j.autrev.2026.104004_bb0370","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2024.122719","article-title":"Deciphering the complex landscape of post-translational modifications on PKM2: implications in head and neck cancer pathogenesis","volume":"349","author":"Singla","year":"2024","journal-title":"Life Sci"},{"issue":"1","key":"10.1016\/j.autrev.2026.104004_bb0375","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.115172","article-title":"Metabolic reprogramming of macrophages by PKM2 promotes IL-10 production via adenosine","volume":"44","author":"Toller-Kawahisa","year":"2025","journal-title":"Cell Rep"},{"issue":"1","key":"10.1016\/j.autrev.2026.104004_bb0380","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1080\/13880209.2023.2173248","article-title":"Panax notoginseng saponins (PNS) attenuate Th17 cell differentiation in CIA mice via inhibition of nuclear PKM2-mediated STAT3 phosphorylation","volume":"61","author":"Shen","year":"2023","journal-title":"Pharm Biol"},{"key":"10.1016\/j.autrev.2026.104004_bb0385","article-title":"Research progress on the role of PKM2 in the immune response","volume":"13","author":"Liu","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.autrev.2026.104004_bb0390","doi-asserted-by":"crossref","first-page":"11845","DOI":"10.2147\/JIR.S497240","article-title":"New posttranslational modification Lactylation brings new inspiration for the treatment of rheumatoid arthritis","volume":"17","author":"Yang","year":"2024","journal-title":"J Inflamm Res"},{"issue":"1","key":"10.1016\/j.autrev.2026.104004_bb0395","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1186\/s12964-024-01624-8","article-title":"Emerging roles of lactate in acute and chronic inflammation","volume":"22","author":"Fang","year":"2024","journal-title":"Cell Commun Signal"},{"key":"10.1016\/j.autrev.2026.104004_bb0400","doi-asserted-by":"crossref","first-page":"2280973","DOI":"10.1155\/2022\/2280973","article-title":"Lactic acid regulation: a potential therapeutic option in rheumatoid arthritis","volume":"2022","author":"Wang","year":"2022","journal-title":"J Immunol Res"},{"issue":"1","key":"10.1016\/j.autrev.2026.104004_bb0405","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s10020-022-00490-9","article-title":"BNIP3 mediates the different adaptive responses of fibroblast-like synovial cells to hypoxia in patients with osteoarthritis and rheumatoid arthritis","volume":"28","author":"Deng","year":"2022","journal-title":"Mol Med (Cambridge, Mass)"},{"key":"10.1016\/j.autrev.2026.104004_bb0410","doi-asserted-by":"crossref","first-page":"1461756","DOI":"10.3389\/fimmu.2024.1461756","article-title":"Overview of mechanisms and novel therapies on rheumatoid arthritis from a cellular perspective","volume":"15","author":"Han","year":"2024","journal-title":"Front Immunol"},{"key":"10.1016\/j.autrev.2026.104004_bb0415","doi-asserted-by":"crossref","first-page":"519","DOI":"10.2147\/DDDT.S391606","article-title":"Anti-arthritic effect of Edaravone against complete Freund adjuvant induced arthritis via osteoclast differentiation and HIF-1\u03b1-VEGF-ANG-1 Axis","volume":"17","author":"Liu","year":"2023","journal-title":"Drug Des Devel Ther"},{"key":"10.1016\/j.autrev.2026.104004_bb0420","article-title":"HIF-1\u03b1 mediates mitochondrial damage by down-regulating ALKBH7 expression to promote the aberrant activation of FLS in rheumatoid arthritis","author":"Wang","year":"2025","journal-title":"Acta Pharmacol Sin"},{"issue":"11","key":"10.1016\/j.autrev.2026.104004_bb0425","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1002\/cbin.11867","article-title":"Regulation of immune cell metabolism in health and disease: special focus on T and B cell subsets","volume":"46","author":"Chakraborty","year":"2022","journal-title":"Cell Biol Int"},{"issue":"4","key":"10.1016\/j.autrev.2026.104004_bb0430","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.163820","article-title":"Hypoxia enhances IPF mesenchymal progenitor cell fibrogenicity via the lactate\/GPR81\/HIF1\u03b1 pathway","volume":"8","author":"Yang","year":"2023","journal-title":"JCI Insight"},{"key":"10.1016\/j.autrev.2026.104004_bb0435","doi-asserted-by":"crossref","unstructured":"Wu H, Mu C, Li X, Fan W, Shen L, Zhu W. Breed-driven microbiome heterogeneity regulates intestinal stem cell proliferation via lactobacillus-lactate-GPR81 signaling. Adv. Sci. (Weinheim, Baden-Wurttemberg, Germany) 2024;vol. 11(33):e2400058. doi:https:\/\/doi.org\/10.1002\/advs.202400058.","DOI":"10.1002\/advs.202400058"},{"issue":"1","key":"10.1016\/j.autrev.2026.104004_bb0440","doi-asserted-by":"crossref","first-page":"2474217","DOI":"10.1080\/08916934.2025.2474217","article-title":"Lactylation-related genes serve as potential markers for the diagnosis and immune infiltration in rheumatoid arthritis","volume":"58","author":"Liu","year":"2025","journal-title":"Autoimmunity"},{"issue":"7","key":"10.1016\/j.autrev.2026.104004_bb0445","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0302119","article-title":"Anti-inflammatory effect of the combined treatment of LMT-28 and kaempferol in a collagen-induced arthritis mouse model","volume":"19","author":"Jeong","year":"2024","journal-title":"PloS One"},{"issue":"1","key":"10.1016\/j.autrev.2026.104004_bb0450","doi-asserted-by":"crossref","first-page":"9034","DOI":"10.1038\/s41467-025-64096-5","article-title":"Histone lactylation promotes rheumatoid arthritis progression by increasing NFATc2 expression and the production of anti-lactylated histone autoantibodies","volume":"16","author":"Wu","year":"2025","journal-title":"Nat Commun"},{"key":"10.1016\/j.autrev.2026.104004_bb0455","doi-asserted-by":"crossref","first-page":"1183825","DOI":"10.3389\/fimmu.2023.1183825","article-title":"Differential effect of lactate on synovial fibroblast and macrophage effector functions","volume":"14","author":"Pucino","year":"2023","journal-title":"Front Immunol"},{"issue":"7","key":"10.1016\/j.autrev.2026.104004_bb0460","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1097\/HJH.0000000000004020","article-title":"Spironolactone protects against hypertension-induced renal fibrosis by promoting autophagy and inhibiting the NLRP3 inflammasome","volume":"43","author":"Zhang","year":"2025","journal-title":"J Hypertens"},{"issue":"2","key":"10.1016\/j.autrev.2026.104004_bb0465","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/s12276-025-01401-8","article-title":"Rheumatoid arthritis severity is mediated by crosstalk between synoviocytes and mature osteoclasts through a calcium and cytokine feedback loop","volume":"57","author":"Lee","year":"2025","journal-title":"Exp Mol Med"},{"issue":"1","key":"10.1016\/j.autrev.2026.104004_bb0470","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1084\/jem.20151570","article-title":"Immunometabolism governs dendritic cell and macrophage function","volume":"213","author":"O\u2019Neill","year":"2016","journal-title":"J Exp Med"},{"issue":"491","key":"10.1016\/j.autrev.2026.104004_bb0475","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aau8587","article-title":"HBEGF(+) macrophages in rheumatoid arthritis induce fibroblast invasiveness","volume":"11","author":"Kuo","year":"2019","journal-title":"Sci Transl Med"},{"issue":"6","key":"10.1016\/j.autrev.2026.104004_bb0480","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.cmet.2020.10.025","article-title":"Succinyl-CoA ligase deficiency in pro-inflammatory and tissue-invasive T cells","volume":"32","author":"Wu","year":"2020","journal-title":"Cell Metab"},{"key":"10.1016\/j.autrev.2026.104004_bb0485","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.839390","article-title":"Alcohol impairs Immunometabolism and promotes na\u00efve T cell differentiation to pro-inflammatory Th1 CD4(+) T cells","volume":"13","author":"McTernan","year":"2022","journal-title":"Front Immunol"},{"issue":"8","key":"10.1016\/j.autrev.2026.104004_bb0490","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1038\/s42255-025-01331-9","article-title":"Lactate signalling leads to aggregation of immune-inflammatory hotspots and SLC5A12 blockade promotes their resolution","volume":"7","author":"Certo","year":"2025","journal-title":"Nat Metab"},{"issue":"5","key":"10.1016\/j.autrev.2026.104004_bb0495","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20202191","article-title":"The metabolism-modulating activity of IL-17 signaling in health and disease","volume":"218","author":"Bechara","year":"2021","journal-title":"J Exp Med"},{"key":"10.1016\/j.autrev.2026.104004_bb0500","article-title":"Metabolic control of autoimmunity and tissue inflammation in rheumatoid arthritis","volume":"12","author":"Qiu","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.autrev.2026.104004_bb0505","doi-asserted-by":"crossref","first-page":"1659541","DOI":"10.3389\/fimmu.2025.1659541","article-title":"Metabolic reprogramming: the central mechanism driving inflammatory polarization in rheumatoid arthritis and the regulatory role of traditional Chinese medicine","volume":"16","author":"Wen","year":"2025","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.autrev.2026.104004_bb0510","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s11658-024-00547-z","article-title":"MRE11A: a novel negative regulator of human DNA mismatch repair","volume":"29","author":"Du","year":"2024","journal-title":"Cell Mol Biol Lett"},{"issue":"9\u201310","key":"10.1016\/j.autrev.2026.104004_bb0515","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1007\/s10495-025-02136-7","article-title":"DNA damage repair inhibitors boost targeted radionuclide therapy and immunotherapy of prostate cancer","volume":"30","author":"Xu","year":"2025","journal-title":"Apoptosis Int J Program Cell Death"},{"issue":"3","key":"10.1016\/j.autrev.2026.104004_bb0520","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/s41590-018-0296-7","article-title":"N-myristoyltransferase deficiency impairs activation of kinase AMPK and promotes synovial tissue inflammation","volume":"20","author":"Wen","year":"2019","journal-title":"Nat Immunol"},{"issue":"1","key":"10.1016\/j.autrev.2026.104004_bb0525","doi-asserted-by":"crossref","first-page":"11952","DOI":"10.1038\/s41598-020-68615-w","article-title":"N-myristoyltransferase-1 is necessary for lysosomal degradation and mTORC1 activation in cancer cells","volume":"10","author":"Chen","year":"2020","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.autrev.2026.104004_bb0530","doi-asserted-by":"crossref","DOI":"10.1002\/jcla.24112","article-title":"Blood MALT1, Th1, and Th17 cells are dysregulated, inter-correlated, and correlated with disease activity in rheumatoid arthritis patients; meanwhile, MALT1 decline during therapy relates to treatment outcome","volume":"36","author":"Ye","year":"2022","journal-title":"J Clin Lab Anal"},{"issue":"9","key":"10.1016\/j.autrev.2026.104004_bb0535","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1038\/ni.3808","article-title":"Metabolic control of the scaffold protein TKS5 in tissue-invasive, proinflammatory T cells","volume":"18","author":"Shen","year":"2017","journal-title":"Nat Immunol"},{"issue":"1","key":"10.1016\/j.autrev.2026.104004_bb0540","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/imr.12838","article-title":"Immunometabolism in the development of rheumatoid arthritis","volume":"294","author":"Weyand","year":"2020","journal-title":"Immunol Rev"},{"key":"10.1016\/j.autrev.2026.104004_bb0545","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110532","article-title":"IL-27 enhances peripheral B cell glycolysis of rheumatoid arthritis patients via activating mTOR signaling","volume":"121","author":"Qi","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.autrev.2026.104004_bb0550","doi-asserted-by":"crossref","first-page":"1232820","DOI":"10.3389\/fimmu.2023.1232820","article-title":"B cell metabolism in autoimmune diseases: signaling pathways and interventions","volume":"14","author":"Li","year":"2023","journal-title":"Front Immunol"},{"issue":"7","key":"10.1016\/j.autrev.2026.104004_bb0555","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2024.167303","article-title":"Follicular CD8(+) T cells promote immunoglobulin production and demyelination in multiple sclerosis and a murine model","volume":"1870","author":"Ding","year":"2024","journal-title":"Biochim Biophys Acta Mol basis Dis"},{"key":"10.1016\/j.autrev.2026.104004_bb0560","doi-asserted-by":"crossref","first-page":"1161148","DOI":"10.3389\/fimmu.2023.1161148","article-title":"The role of dendritic cells and their immunometabolism in rheumatoid arthritis","volume":"14","author":"Suwa","year":"2023","journal-title":"Front Immunol"},{"issue":"12","key":"10.1016\/j.autrev.2026.104004_bb0565","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1016\/j.immuni.2024.11.012","article-title":"DC-T cell power couples in rheumatoid arthritis joints","volume":"57","author":"Higashioka","year":"2024","journal-title":"Immunity"},{"issue":"12","key":"10.1016\/j.autrev.2026.104004_bb0570","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1016\/j.immuni.2024.11.004","article-title":"Synovial tissue myeloid dendritic cell subsets exhibit distinct tissue-niche localization and function in health and rheumatoid arthritis","volume":"57","author":"MacDonald","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.autrev.2026.104004_bb0575","doi-asserted-by":"crossref","first-page":"1073971","DOI":"10.3389\/fimmu.2022.1073971","article-title":"Emerging role of hypoxia-inducible factor-1\u03b1 in inflammatory autoimmune diseases: a comprehensive review","volume":"13","author":"Tang","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.autrev.2026.104004_bb0580","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2023.156136","article-title":"Majoon chobchini reinstates PDL-1 expression and blocks dendritic cell -T helper 17 pathogenic axis in rheumatoid arthritis animal model","volume":"163","author":"Samarpita","year":"2023","journal-title":"Cytokine"},{"key":"10.1016\/j.autrev.2026.104004_bb0585","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.freeradbiomed.2025.04.008","article-title":"Mitochondrial calcium uniporter regulates human fibroblast-like synoviocytes invasion via altering mitochondrial dynamics and dictates rheumatoid arthritis pathogenesis","volume":"234","author":"Promila","year":"2025","journal-title":"Free Radic Biol Med"},{"issue":"4","key":"10.1016\/j.autrev.2026.104004_bb0590","doi-asserted-by":"crossref","DOI":"10.1002\/eji.202451381","article-title":"Metabolic reprogramming in stromal and immune cells in rheumatoid arthritis and osteoarthritis: therapeutic possibilities","volume":"55","author":"Henry","year":"2025","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.autrev.2026.104004_bb0595","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.984408","article-title":"Solute carrier nutrient transporters in rheumatoid arthritis fibroblast-like synoviocytes","volume":"13","author":"Torres","year":"2022","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.autrev.2026.104004_bb0600","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41540-023-00294-5","article-title":"A large-scale Boolean model of the rheumatoid arthritis fibroblast-like synoviocytes predicts drug synergies in the arthritic joint","volume":"9","author":"Singh","year":"2023","journal-title":"NPJ Syste Biolo Appl"},{"key":"10.1016\/j.autrev.2026.104004_bb0605","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116195","article-title":"Nitazoxanide reduces inflammation and bone erosion in mice with collagen-induced arthritis via inhibiting the JAK2\/STAT3 and NF-\u03baB pathways in fibroblast-like synoviocytes","volume":"171","author":"Li","year":"2024","journal-title":"Biomed Pharmacother"},{"issue":"5","key":"10.1016\/j.autrev.2026.104004_bb0610","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1007\/s12011-022-03315-2","article-title":"HIF-1\u03b1 mediates arsenic-induced metabolic reprogramming in lung bronchial epithelial cells","volume":"201","author":"Wang","year":"2023","journal-title":"Biol Trace Elem Res"},{"issue":"4","key":"10.1016\/j.autrev.2026.104004_bb0615","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1093\/gerona\/glad009","article-title":"Resveratrol alleviates inflammation and ER stress through SIRT1\/NRF2 to delay ovarian aging in a short-lived fish","volume":"78","author":"Zhu","year":"2023","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"17","key":"10.1016\/j.autrev.2026.104004_bb0620","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e37083","article-title":"Acacetin protects against acute lung injury by upregulating SIRT1\/ NF-\u03baB pathway","volume":"10","author":"Gu","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.autrev.2026.104004_bb0625","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.998554","article-title":"The monocyte-to-osteoclast transition in rheumatoid arthritis: recent findings","volume":"13","author":"Iwamoto","year":"2022","journal-title":"Front Immunol"},{"issue":"7","key":"10.1016\/j.autrev.2026.104004_bb0630","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1302\/2046-3758.117.BJR-2021-0594.R1","article-title":"Immunomodulatory role of T helper cells in rheumatoid arthritis\u202f: a comprehensive research review","volume":"11","author":"Luo","year":"2022","journal-title":"Bone Joint Res"},{"issue":"51","key":"10.1016\/j.autrev.2026.104004_bb0635","doi-asserted-by":"crossref","first-page":"16176","DOI":"10.1021\/acs.jafc.2c05802","article-title":"Echinocystic acid ameliorates arthritis in SKG mice by suppressing Th17 cell differentiation and human rheumatoid arthritis fibroblast-like Synoviocytes inflammation","volume":"70","author":"Cheng","year":"2022","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.autrev.2026.104004_bb0640","doi-asserted-by":"crossref","first-page":"1000865","DOI":"10.3389\/fphar.2022.1000865","article-title":"The bone-protective mechanisms of active components from TCM drugs in rheumatoid arthritis treatment","volume":"13","author":"Lu","year":"2022","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.autrev.2026.104004_bb0645","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.molimm.2021.10.007","article-title":"The glycolysis inhibitor 2-deoxyglucose ameliorates adjuvant-induced arthritis by regulating macrophage polarization in an AMPK-dependent manner","volume":"140","author":"Cai","year":"2021","journal-title":"Mol Immunol"},{"key":"10.1016\/j.autrev.2026.104004_bb0650","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.176551","article-title":"Small-molecule targeting PKM2 provides a molecular basis of lactylation-dependent fibroblast-like synoviocytes proliferation inhibition against rheumatoid arthritis","volume":"972","author":"Wang","year":"2024","journal-title":"Eur J Pharmacol"},{"issue":"8","key":"10.1016\/j.autrev.2026.104004_bb0655","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1038\/s41401-024-01264-1","article-title":"Transcriptional regulation and post-translational modifications in the glycolytic pathway for targeted cancer therapy","volume":"45","author":"Ni","year":"2024","journal-title":"Acta Pharmacol Sin"},{"issue":"1","key":"10.1016\/j.autrev.2026.104004_bb0660","doi-asserted-by":"crossref","first-page":"9166","DOI":"10.1038\/s41598-024-59907-6","article-title":"Unveiling the link between lactate metabolism and rheumatoid arthritis through integration of bioinformatics and machine learning","volume":"14","author":"Yang","year":"2024","journal-title":"Sci Rep"},{"issue":"12","key":"10.1016\/j.autrev.2026.104004_bb0665","doi-asserted-by":"crossref","first-page":"9524","DOI":"10.1002\/jcp.29759","article-title":"FoxA2 inhibits the proliferation of hepatic progenitor cells by reducing PI3K\/Akt\/HK2-mediated glycolysis","volume":"235","author":"Wang","year":"2020","journal-title":"J Cell Physiol"},{"issue":"8","key":"10.1016\/j.autrev.2026.104004_bb0670","doi-asserted-by":"crossref","first-page":"3419","DOI":"10.1002\/ptr.70019","article-title":"Geniposide improves glycolysis driven angiogenesis in Experimentary arthritis by inhibiting SphK1-PI3K-Akt-PFKFB3 signal","volume":"39","author":"Bu","year":"2025","journal-title":"Phytother Res"},{"issue":"6","key":"10.1016\/j.autrev.2026.104004_bb0675","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s11626-022-00694-7","article-title":"Calycosin prevents IL-1\u03b2-induced articular chondrocyte damage in osteoarthritis through regulating the PI3K\/AKT\/FoxO1 pathway","volume":"58","author":"Guo","year":"2022","journal-title":"In Vitro Cell Dev Biol Anim"},{"key":"10.1016\/j.autrev.2026.104004_bb0680","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.freeradbiomed.2023.07.036","article-title":"Piezoeletric cold atmospheric plasma induces apoptosis and autophagy in human hepatocellular carcinoma cells through blocking glycolysis and AKT\/mTOR\/HIF-1\u03b1 pathway","volume":"208","author":"Wang","year":"2023","journal-title":"Free Radic Biol Med"},{"issue":"9","key":"10.1016\/j.autrev.2026.104004_bb0685","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1038\/s41416-018-0242-3","article-title":"Metabolic biomarkers of response to the AKT inhibitor MK-2206 in pre-clinical models of human colorectal and prostate carcinoma","volume":"119","author":"Al-Saffar","year":"2018","journal-title":"Br J Cancer"},{"issue":"1","key":"10.1016\/j.autrev.2026.104004_bb0690","doi-asserted-by":"crossref","first-page":"19385","DOI":"10.1038\/s41598-021-98651-z","article-title":"TNF induces glycolytic shift in fibroblast like synoviocytes via GLUT1 and HIF1A","volume":"11","author":"Koedderitzsch","year":"2021","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.autrev.2026.104004_bb0695","doi-asserted-by":"crossref","DOI":"10.1093\/jleuko\/qiae215","article-title":"Intracellular methylglyoxal accumulation in classically activated mouse macrophages is mediated by HIF-1\u03b1","volume":"117","author":"Prantner","year":"2025","journal-title":"J Leukoc Biol"},{"issue":"3","key":"10.1016\/j.autrev.2026.104004_bb0700","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.immuni.2019.01.021","article-title":"CCR7 chemokine receptor-inducible lnc-Dpf3 restrains dendritic cell migration by inhibiting HIF-1\u03b1-mediated glycolysis","volume":"50","author":"Liu","year":"2019","journal-title":"Immunity"},{"issue":"4","key":"10.1016\/j.autrev.2026.104004_bb0705","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1080\/10409238.2022.2088684","article-title":"Hypoxia-regulated microRNAs: the molecular drivers of tumor progression","volume":"57","author":"Sawai","year":"2022","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"10.1016\/j.autrev.2026.104004_bb0710","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2025.102894","article-title":"Iguratimod modulates osteoclast differentiation in rheumatoid arthritis: insights into AMPK\/HIF-1\u03b1 signaling pathway regulation","volume":"95","author":"Ying","year":"2025","journal-title":"Tissue Cell"},{"issue":"20","key":"10.1016\/j.autrev.2026.104004_bb0715","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242015186","article-title":"Endoplasmic reticulum stress promotes the expression of TNF-\u03b1 in THP-1 cells by mechanisms involving ROS\/CHOP\/HIF-1\u03b1 and MAPK\/NF-\u03baB pathways","volume":"24","author":"Akhter","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.autrev.2026.104004_bb0720","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.actbio.2022.08.054","article-title":"An ROS-responsive artesunate prodrug nanosystem co-delivers dexamethasone for rheumatoid arthritis treatment through the HIF-1\u03b1\/NF-\u03baB cascade regulation of ROS scavenging and macrophage repolarization","volume":"152","author":"Li","year":"2022","journal-title":"Acta Biomater"},{"key":"10.1016\/j.autrev.2026.104004_bb0725","first-page":"9279078","article-title":"MicroRNA-21 promotes proliferation of fibroblast-like synoviocytes through mediation of NF-\u03baB nuclear translocation in a rat model of collagen-induced rheumatoid arthritis","volume":"2016","author":"Chen","year":"2016","journal-title":"Biomed Res Int"}],"container-title":["Autoimmunity Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568997226000182?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568997226000182?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T11:15:33Z","timestamp":1788174933000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568997226000182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":145,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S1568997226000182"],"URL":"https:\/\/doi.org\/10.1016\/j.autrev.2026.104004","relation":{},"ISSN":["1568-9972"],"issn-type":[{"value":"1568-9972","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regulatory mechanisms and targeted therapeutic strategies of glycolytic metabolism in rheumatoid arthritis","name":"articletitle","label":"Article Title"},{"value":"Autoimmunity Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.autrev.2026.104004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104004"}}