{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T08:15:46Z","timestamp":1783152946766,"version":"3.54.6"},"reference-count":122,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2022MH023"],"award-info":[{"award-number":["ZR2022MH023"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020196","name":"Shandong Provincial Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["SDZZ-ZR-202501205"],"award-info":[{"award-number":["SDZZ-ZR-202501205"]}],"id":[{"id":"10.13039\/501100020196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Autoimmunity Reviews"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.autrev.2026.104072","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T07:04:43Z","timestamp":1778137483000},"page":"104072","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["The role of mitophagy in systemic lupus erythematosus"],"prefix":"10.1016","volume":"25","author":[{"given":"Yujiao","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyu","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.autrev.2026.104072_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2024.101170","article-title":"Autophagy in cancer development, immune evasion, and drug resistance","volume":"78","author":"Niu","year":"2025","journal-title":"Drug Resist Updat"},{"key":"10.1016\/j.autrev.2026.104072_bb0010","article-title":"Microautophagy: current understanding of its molecular mechanisms and functions","volume":"5","author":"Sakai","year":"2026","journal-title":"Autophagy Rep"},{"key":"10.1016\/j.autrev.2026.104072_bb0015","article-title":"Critical roles and molecular mechanisms of chaperone-mediated autophagy in infections","volume":"27","author":"Wang","year":"2026","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.autrev.2026.104072_bb0020","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines9111625","article-title":"Macroautophagy and mitophagy in neurodegenerative disorders: focus on therapeutic interventions","volume":"9","author":"Magalh\u00e3es","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.autrev.2026.104072_bb0025","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1007\/s10495-024-01977-y","article-title":"Mitophagy in health and disease. molecular mechanisms, regulatory pathways, and therapeutic implications","volume":"29","author":"D\u2019Arcy","year":"2024","journal-title":"Apoptosis"},{"key":"10.1016\/j.autrev.2026.104072_bb0030","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/15548627.2019.1603547","article-title":"Emerging views of mitophagy in immunity and autoimmune diseases","volume":"16","author":"Xu","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.autrev.2026.104072_bb0035","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1080\/03009742.2024.2420432","article-title":"Mitophagy drives maldifferentiation of tissue-resident memory T cells in patients with rheumatoid arthritis","volume":"54","author":"Liu","year":"2025","journal-title":"Scand J Rheumatol"},{"key":"10.1016\/j.autrev.2026.104072_bb0040","doi-asserted-by":"crossref","first-page":"717","DOI":"10.2147\/JAA.S467774","article-title":"NLRP3 inflammasome deficiency alleviates inflammation and oxidative stress by promoting PINK1\/parkin-mediated mitophagy in allergic rhinitis mice and nasal epithelial cells","volume":"17","author":"Ding","year":"2024","journal-title":"J Asthma Allergy"},{"key":"10.1016\/j.autrev.2026.104072_bb0045","doi-asserted-by":"crossref","first-page":"11521","DOI":"10.2147\/JIR.S527859","article-title":"Anti-PS IgG immune complexes impair macrophage phagocytosis in SLE via LOX-dependent oxidative stress","volume":"18","author":"Guan","year":"2025","journal-title":"J Inflamm Res"},{"key":"10.1016\/j.autrev.2026.104072_bb0050","doi-asserted-by":"crossref","DOI":"10.3390\/jcm14165714","article-title":"Autoantibodies in systemic lupus erythematosus: diagnostic and pathogenic insights","volume":"14","author":"Pagkopoulou","year":"2025","journal-title":"J Clin Med"},{"key":"10.1016\/j.autrev.2026.104072_bb0055","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202114182","article-title":"Detection and functional resolution of soluble immune complexes by an Fc\u03b3R reporter cell panel","volume":"14","author":"Chen","year":"2022","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.autrev.2026.104072_bb0060","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.cytogfr.2024.11.006","article-title":"LC3B: a microtubule-associated protein influences disease progression and prognosis","volume":"81","author":"Chen","year":"2025","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.autrev.2026.104072_bb0065","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41422-025-01203-7","article-title":"Mitophagy in the pathogenesis and management of disease","volume":"36","author":"Wang","year":"2026","journal-title":"Cell Res"},{"key":"10.1016\/j.autrev.2026.104072_bb0070","doi-asserted-by":"crossref","first-page":"736","DOI":"10.7150\/thno.79876","article-title":"Cellular mitophagy: mechanism, roles in diseases and small molecule pharmacological regulation","volume":"13","author":"Lu","year":"2023","journal-title":"Theranostics"},{"key":"10.1016\/j.autrev.2026.104072_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmb.2025.169161","article-title":"Mitophagy in neurons: mechanisms regulating mitochondrial turnover and neuronal homeostasis","volume":"437","author":"Basak","year":"2025","journal-title":"J Mol Biol"},{"key":"10.1016\/j.autrev.2026.104072_bb0080","doi-asserted-by":"crossref","first-page":"5989","DOI":"10.1038\/s41467-021-26295-8","article-title":"Phase separation of Nur77 mediates celastrol-induced mitophagy by promoting the liquidity of p62\/SQSTM1 condensates","volume":"12","author":"Peng","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.autrev.2026.104072_bb0085","doi-asserted-by":"crossref","first-page":"4039","DOI":"10.1073\/pnas.1523926113","article-title":"Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria","volume":"113","author":"Richter","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.autrev.2026.104072_bb0090","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1080\/15548627.2021.1888244","article-title":"Regulation of PRKN-independent mitophagy","volume":"18","author":"Tere\u0161ak","year":"2022","journal-title":"Autophagy"},{"key":"10.1016\/j.autrev.2026.104072_bb0095","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1080\/15548627.2020.1725377","article-title":"Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles","volume":"17","author":"Yao","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.autrev.2026.104072_bb0100","article-title":"Mitophagy and oxidative stress in chronic kidney disease (review)","volume":"33","author":"Mushuo","year":"2026","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.autrev.2026.104072_bb0105","doi-asserted-by":"crossref","first-page":"855","DOI":"10.4161\/auto.6.7.13005","article-title":"Bnip3-mediated mitochondrial autophagy is independent of the mitochondrial permeability transition pore","volume":"6","author":"Quinsay","year":"2010","journal-title":"Autophagy"},{"key":"10.1016\/j.autrev.2026.104072_bb0110","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.semcancer.2019.07.015","article-title":"The emerging, multifaceted role of mitophagy in cancer and cancer therapeutics","volume":"66","author":"Panigrahi","year":"2020","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/j.autrev.2026.104072_bb0115","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1038\/s41419-022-05418-z","article-title":"BNIP3 phosphorylation by JNK1\/2 promotes mitophagy via enhancing its stability under hypoxia","volume":"13","author":"He","year":"2022","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.autrev.2026.104072_bb0120","first-page":"92","article-title":"Research progress on mechanism of Nix-mediated mitophagy","volume":"46","author":"Zheng","year":"2017","journal-title":"Zhejiang Da Xue Xue Bao Yi Xue Ban"},{"key":"10.1016\/j.autrev.2026.104072_bb0125","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/embor.2009.256","article-title":"Nix is a selective autophagy receptor for mitochondrial clearance","volume":"11","author":"Novak","year":"2010","journal-title":"EMBO Rep"},{"key":"10.1016\/j.autrev.2026.104072_bb0130","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1093\/hmg\/ddv017","article-title":"The mitochondrial protein BNIP3L is the substrate of PARK2 and mediates mitophagy in PINK1\/PARK2 pathway","volume":"24","author":"Gao","year":"2015","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.autrev.2026.104072_bb0135","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.788634","article-title":"FUNDC1: a promising mitophagy regulator at the mitochondria-associated membrane for cardiovascular diseases","volume":"9","author":"Li","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.autrev.2026.104072_bb0140","doi-asserted-by":"crossref","DOI":"10.1002\/cbf.70125","article-title":"A review of FUN14 domain-containing 1 involvement in mitochondrial biological processes and mechanisms across various systems","volume":"43","author":"He","year":"2025","journal-title":"Cell Biochem Funct"},{"key":"10.1016\/j.autrev.2026.104072_bb0145","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1042\/EBC20170104","article-title":"Mitochondrial dynamics: overview of molecular mechanisms","volume":"62","author":"Tilokani","year":"2018","journal-title":"Essays Biochem"},{"key":"10.1016\/j.autrev.2026.104072_bb0150","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1002\/1873-3468.14077","article-title":"Mitochondrial dynamics in health and disease","volume":"595","author":"Yapa","year":"2021","journal-title":"FEBS Lett"},{"key":"10.1016\/j.autrev.2026.104072_bb0155","article-title":"Mitochondrial fission and fusion: molecular mechanisms, biological functions, and related disorders","volume":"12","author":"Al Ojaimi","year":"2022","journal-title":"Membranes (Basel)"},{"key":"10.1016\/j.autrev.2026.104072_bb0160","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.nbd.2010.09.009","article-title":"Mitochondrial autophagy in neural function, neurodegenerative disease, neuron cell death, and aging","volume":"43","author":"Batlevi","year":"2011","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.autrev.2026.104072_bb0165","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1080\/15548627.2016.1151580","article-title":"Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy","volume":"12","author":"Chen","year":"2016","journal-title":"Autophagy"},{"key":"10.1016\/j.autrev.2026.104072_bb0170","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.7150\/ijbs.83348","article-title":"The crosstalk between ferroptosis and mitochondrial dynamic regulatory networks","volume":"19","author":"Li","year":"2023","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.autrev.2026.104072_bb0175","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/s41420-025-02458-0","article-title":"DRP1, fission and apoptosis","volume":"11","author":"Wang","year":"2025","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.autrev.2026.104072_bb0180","doi-asserted-by":"crossref","first-page":"5239","DOI":"10.1038\/s41467-018-07543-w","article-title":"Dynamin-related protein 1 has membrane constricting and severing abilities sufficient for mitochondrial and peroxisomal fission","volume":"9","author":"Kamerkar","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.autrev.2026.104072_bb0185","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1016\/j.molcel.2023.04.022","article-title":"The mitochondrial intermembrane space protein mitofissin drives mitochondrial fission required for mitophagy","volume":"83","author":"Fukuda","year":"2023","journal-title":"Mol Cell"},{"key":"10.1016\/j.autrev.2026.104072_bb0190","doi-asserted-by":"crossref","first-page":"3791","DOI":"10.1007\/s00018-021-03772-3","article-title":"At the heart of mitochondrial quality control: many roads to the top","volume":"78","author":"Gottlieb","year":"2021","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.autrev.2026.104072_bb0195","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1080\/15548627.2020.1821548","article-title":"BNIP3L\/Nix-induced mitochondrial fission, mitophagy, and impaired myocyte glucose uptake are abrogated by PRKA\/PKA phosphorylation","volume":"17","author":"da Silva Rosa","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.autrev.2026.104072_bb0200","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201948686","article-title":"PINK1 phosphorylates Drp1(S616) to regulate mitophagy-independent mitochondrial dynamics","volume":"21","author":"Han","year":"2020","journal-title":"EMBO Rep"},{"key":"10.1016\/j.autrev.2026.104072_bb0205","doi-asserted-by":"crossref","first-page":"479","DOI":"10.3389\/fphys.2016.00479","article-title":"Mitochondrial quality control in cardiac diseases","volume":"7","author":"Campos","year":"2016","journal-title":"Front Physiol"},{"key":"10.1016\/j.autrev.2026.104072_bb0210","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.4161\/auto.21741","article-title":"Involvement of autophagy and mitochondrial dynamics in determining the fate and effects of irreparable mitochondrial DNA damage","volume":"8","author":"Meyer","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.autrev.2026.104072_bb0215","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1083\/jcb.201007013","article-title":"Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin","volume":"191","author":"Tanaka","year":"2010","journal-title":"J Cell Biol"},{"key":"10.1016\/j.autrev.2026.104072_bb0220","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1126\/science.1231031","article-title":"PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria","volume":"340","author":"Chen","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.autrev.2026.104072_bb0225","doi-asserted-by":"crossref","first-page":"10807","DOI":"10.2147\/JIR.S497813","article-title":"Overproduction of mitochondrial fission proteins and mitochondrial fission in podocytes of lupus nephritis patients","volume":"17","author":"Wei","year":"2024","journal-title":"J Inflamm Res"},{"key":"10.1016\/j.autrev.2026.104072_bb0230","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1007\/s12026-024-09535-z","article-title":"The dysregulation of mitochondrial homeostasis-related genes could be involved in the decrease of mtDNA copy number in systemic lupus erythematosus patients","volume":"72","author":"De Benedittis","year":"2024","journal-title":"Immunol Res"},{"key":"10.1016\/j.autrev.2026.104072_bb0235","article-title":"mtDNA heteroplasmy: origin, detection, significance, and evolutionary consequences","volume":"11","author":"Parakatselaki","year":"2021","journal-title":"Life (Basel)"},{"key":"10.1016\/j.autrev.2026.104072_bb0240","article-title":"Targeting the ROS-ferroptosis axis: a clinical perspective on oxidative stress management in systemic lupus erythematosus","author":"Xu","year":"2025","journal-title":"Am J Med Sci"},{"key":"10.1016\/j.autrev.2026.104072_bb0245","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s00204-025-04206-w","article-title":"cGAS-STING and autophagy: crosstalk, molecular mechanisms, and targeted therapy","volume":"100","author":"Wang","year":"2026","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.autrev.2026.104072_bb0250","article-title":"Improvement of the anticancer efficacy of PD-1\/PD-L1 blockade: advances in molecular mechanisms and therapeutic strategies","volume":"6","author":"Gao","year":"2025","journal-title":"MedComm (2020)"},{"key":"10.1016\/j.autrev.2026.104072_bb0255","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13622","article-title":"Defective mitophagy in aged macrophages promotes mitochondrial DNA cytosolic leakage to activate STING signaling during liver sterile inflammation","volume":"21","author":"Zhong","year":"2022","journal-title":"Aging Cell"},{"key":"10.1016\/j.autrev.2026.104072_bb0260","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.1016\/j.apsb.2024.05.012","article-title":"Mitophagy and cGAS-STING crosstalk in neuroinflammation","volume":"14","author":"Zhou","year":"2024","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.autrev.2026.104072_bb0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116698","article-title":"Relationship between the cGAS-STING and NF-\u03baB pathways-role in neurotoxicity","volume":"175","author":"Zhong","year":"2024","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.autrev.2026.104072_bb0270","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.clim.2012.07.001","article-title":"Metabolic regulation of organelle homeostasis in lupus T cells","volume":"144","author":"Caza","year":"2012","journal-title":"Clin Immunol"},{"key":"10.1016\/j.autrev.2026.104072_bb0275","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/rai2.12119","article-title":"Mitochondrial aberrations in systemic lupus erythematosus pathogenesis: insights and therapeutic implications","volume":"4","author":"Li","year":"2024","journal-title":"Rheumatol Autoimmun"},{"key":"10.1016\/j.autrev.2026.104072_bb0280","article-title":"Mitochondrial impairment and repair in the pathogenesis of systemic lupus erythematosus","volume":"13","author":"Zhao","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.autrev.2026.104072_bb0285","doi-asserted-by":"crossref","first-page":"453","DOI":"10.2147\/JIR.S399284","article-title":"Oxidative stress contributes to inflammatory and cellular damage in systemic lupus erythematosus: cellular markers and molecular mechanism","volume":"16","author":"Yan","year":"2023","journal-title":"J Inflamm Res"},{"key":"10.1016\/j.autrev.2026.104072_bb0290","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.4049\/jimmunol.2100969","article-title":"Protection of quiescence and longevity of IgG memory B cells by mitochondrial autophagy","volume":"208","author":"Kodali","year":"2022","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2026.104072_bb0295","doi-asserted-by":"crossref","DOI":"10.1155\/2024\/5577506","article-title":"Mitochondrial quality control orchestrates the symphony of B cells and plays critical roles in B cell-related diseases","volume":"2024","author":"Li","year":"2024","journal-title":"J Immunol Res"},{"key":"10.1016\/j.autrev.2026.104072_bb0300","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.4049\/jimmunol.1901474","article-title":"AMPK\u03b11 in B cells dampens primary antibody responses yet promotes mitochondrial homeostasis and persistence of B cell memory","volume":"205","author":"Brookens","year":"2020","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2026.104072_bb0305","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2023-003104","article-title":"Neutrophil extracellular traps (NET): not only antimicrobial but also modulators of innate and adaptive immunities in inflammatory autoimmune diseases","volume":"9","author":"Melbouci","year":"2023","journal-title":"RMD Open"},{"key":"10.1016\/j.autrev.2026.104072_bb0310","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.3899\/jrheum.190875","article-title":"Role of neutrophil extracellular traps regarding patients at risk of increased disease activity and cardiovascular comorbidity in systemic lupus erythematosus","volume":"47","author":"Moore","year":"2020","journal-title":"J Rheumatol"},{"key":"10.1016\/j.autrev.2026.104072_bb0315","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1084\/jem.20151876","article-title":"Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus","volume":"213","author":"Caielli","year":"2016","journal-title":"J Exp Med"},{"key":"10.1016\/j.autrev.2026.104072_bb0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102906","article-title":"Neutrophil extracellular traps drive intestinal microvascular endothelial ferroptosis by impairing Fundc1-dependent mitophagy","volume":"67","author":"Chu","year":"2023","journal-title":"Redox Biol"},{"key":"10.1016\/j.autrev.2026.104072_bb0325","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/s40064-015-0932-8","article-title":"Prolonged exposure to neutrophil extracellular traps can induce mitochondrial damage in macrophages and dendritic cells","volume":"4","author":"Donis-Maturano","year":"2015","journal-title":"Springerplus"},{"key":"10.1016\/j.autrev.2026.104072_bb0330","article-title":"M1 and M2 macrophage polarization correlates with activity and chronicity indices in lupus nephritis","volume":"15","author":"Chavanisakun","year":"2025","journal-title":"Life (Basel)"},{"key":"10.1016\/j.autrev.2026.104072_bb0335","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1016\/j.jfma.2021.03.019","article-title":"Immunometabolism in systemic lupus erythematosus: relevant pathogenetic mechanisms and potential clinical applications","volume":"120","author":"Tzeng","year":"2021","journal-title":"J Formos Med Assoc"},{"key":"10.1016\/j.autrev.2026.104072_bb0340","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s11926-019-0842-9","article-title":"Innate immune dysregulation in the development of cardiovascular disease in lupus","volume":"21","author":"Tumurkhuu","year":"2019","journal-title":"Curr Rheumatol Rep"},{"key":"10.1016\/j.autrev.2026.104072_bb0345","doi-asserted-by":"crossref","DOI":"10.3390\/biom15050647","article-title":"Low fluoride regulates macrophage polarization through mitochondrial autophagy mediated by PINK1\/Parkin axis","volume":"15","author":"Xie","year":"2025","journal-title":"Biomolecules"},{"key":"10.1016\/j.autrev.2026.104072_bb0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107258","article-title":"Cardiovascular disease: mitochondrial dynamics and mitophagy crosstalk mechanisms with novel programmed cell death and macrophage polarisation","volume":"206","author":"Liu","year":"2024","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.autrev.2026.104072_bb0355","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23010003","article-title":"IL-25 induced ROS-mediated M2 macrophage polarization via AMPK-associated mitophagy","volume":"23","author":"Tsai","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.autrev.2026.104072_bb0360","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1562221","article-title":"Myeloid cells as IFN\u03b1 producers in systemic lupus erythematosus","volume":"16","author":"Kuga","year":"2025","journal-title":"Front Immunol"},{"key":"10.1016\/j.autrev.2026.104072_bb0365","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1080\/08916934.2022.2112181","article-title":"Mitochondria as a key player in systemic lupus erythematosus","volume":"55","author":"Quintero-Gonz\u00e1lez","year":"2022","journal-title":"Autoimmunity"},{"key":"10.1016\/j.autrev.2026.104072_bb0370","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.celrep.2018.09.001","article-title":"IFN\u03b1 impairs autophagic degradation of mtDNA promoting autoreactivity of SLE monocytes in a STING-dependent fashion","volume":"25","author":"Gkirtzimanaki","year":"2018","journal-title":"Cell Rep"},{"key":"10.1016\/j.autrev.2026.104072_bb0375","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1126\/science.1064890","article-title":"Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus","volume":"294","author":"Blanco","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.autrev.2026.104072_bb0380","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41390-019-0343-6","article-title":"The emerging role of immunothrombosis in paediatric conditions","volume":"86","author":"Franchi","year":"2019","journal-title":"Pediatr Res"},{"key":"10.1016\/j.autrev.2026.104072_bb0385","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1302\/2046-3758.139.BJR-2024-0122.R1","article-title":"The interactions of macrophages, lymphocytes, and mesenchymal stem cells during bone regeneration","volume":"13","author":"Murayama","year":"2024","journal-title":"Bone Jt Res"},{"key":"10.1016\/j.autrev.2026.104072_bb0390","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/s41577-018-0029-z","article-title":"IFN\u03b3: signalling, epigenetics and roles in immunity, metabolism, disease and cancer immunotherapy","volume":"18","author":"Ivashkiv","year":"2018","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.autrev.2026.104072_bb0395","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2023.156437","article-title":"The role of Interleukin-21 in autoimmune diseases: mechanisms, therapeutic implications, and future directions","volume":"173","author":"Shbeer","year":"2024","journal-title":"Cytokine"},{"key":"10.1016\/j.autrev.2026.104072_bb0400","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2020.00935","article-title":"Mechanisms and functions of mitophagy and potential roles in renal disease","volume":"11","author":"Zuo","year":"2020","journal-title":"Front Physiol"},{"key":"10.1016\/j.autrev.2026.104072_bb0405","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s12079-020-00594-z","article-title":"The role of extracellular vesicles in podocyte autophagy in kidney disease","volume":"15","author":"Sun","year":"2021","journal-title":"J Cell Commun Signal"},{"key":"10.1016\/j.autrev.2026.104072_bb0410","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25116162","article-title":"Mitochondrial dysfunction in systemic lupus erythematosus with a focus on lupus nephritis","volume":"25","author":"Halfon","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.autrev.2026.104072_bb0415","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1016\/j.ymthe.2024.03.003","article-title":"C5a-C5aR1 axis controls mitochondrial fission to promote podocyte injury in lupus nephritis","volume":"32","author":"Ye","year":"2024","journal-title":"Mol Ther"},{"key":"10.1016\/j.autrev.2026.104072_bb0420","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2022.102865","article-title":"Recent advances in cutaneous lupus","volume":"132","author":"Maz","year":"2022","journal-title":"J Autoimmun"},{"key":"10.1016\/j.autrev.2026.104072_bb0425","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12030987","article-title":"Current knowledge of the molecular pathogenesis of cutaneous lupus erythematosus","volume":"12","author":"Miyagawa","year":"2023","journal-title":"J Clin Med"},{"key":"10.1016\/j.autrev.2026.104072_bb0430","doi-asserted-by":"crossref","first-page":"7908","DOI":"10.1038\/s41598-020-64865-w","article-title":"The early local and systemic type I interferon responses to ultraviolet B light exposure are cGAS dependent","volume":"10","author":"Skopelja-Gardner","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.autrev.2026.104072_bb0435","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14186","article-title":"Elimination of damaged mitochondria during UVB-induced senescence is orchestrated by NIX-dependent mitophagy","volume":"23","author":"Cavinato","year":"2024","journal-title":"Aging Cell"},{"key":"10.1016\/j.autrev.2026.104072_bb0440","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.freeradbiomed.2024.10.272","article-title":"FUNDC1-mediated mitophagy regulates photodamage independently of the PINK1\/Parkin-dependent pathway","volume":"225","author":"He","year":"2024","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.autrev.2026.104072_bb0445","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.bbrc.2022.05.066","article-title":"REDD1 interacts with AIF and regulates mitochondrial reactive oxygen species generation in the keratinocyte response to UVB","volume":"616","author":"Feehan","year":"2022","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.autrev.2026.104072_bb0450","doi-asserted-by":"crossref","first-page":"102","DOI":"10.2478\/rir-2023-0015","article-title":"Lupus with initial mesenteric vasculitis","volume":"4","author":"Xie","year":"2023","journal-title":"Rheumatol Immunol Res"},{"key":"10.1016\/j.autrev.2026.104072_bb0455","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.706743","article-title":"Antiphospholipid antibodies from women with pregnancy morbidity and vascular thrombosis induce endothelial mitochondrial dysfunction, mTOR activation, and autophagy","volume":"12","author":"Rodr\u00edguez","year":"2021","journal-title":"Front Physiol"},{"key":"10.1016\/j.autrev.2026.104072_bb0460","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202109144","article-title":"A mitochondrial contribution to anti-inflammatory shear stress signaling in vascular endothelial cells","volume":"221","author":"Coon","year":"2022","journal-title":"J Cell Biol"},{"key":"10.1016\/j.autrev.2026.104072_bb0465","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.18190","article-title":"Microglia orchestrate synaptic and neuronal stripping: implication in neuropsychiatric lupus","volume":"28","author":"Zhou","year":"2024","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.autrev.2026.104072_bb0470","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/j.ard.2025.04.006","article-title":"Enhanced B cell and complement cascade gene signatures in patients with neuropsychiatric systemic lupus erythematosus","volume":"84","author":"Nikolopoulos","year":"2025","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2026.104072_bb0475","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1080\/15548627.2019.1704104","article-title":"Oxidation of multiple MiT\/TFE transcription factors links oxidative stress to transcriptional control of autophagy and lysosome biogenesis","volume":"16","author":"Wang","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.autrev.2026.104072_bb0480","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1007\/s10067-025-07520-x","article-title":"Management of newly diagnosed lupus nephritis in China: an implementation study based on the 2023 EULAR recommendations","volume":"44","author":"Bai","year":"2025","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.autrev.2026.104072_bb0485","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22116054","article-title":"Mitochondrial glucocorticoid receptors and their actions","volume":"22","author":"Kokkinopoulou","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.autrev.2026.104072_bb0490","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/s41467-020-20679-y","article-title":"BNIP3L\/NIX-mediated mitophagy protects against glucocorticoid-induced synapse defects","volume":"12","author":"Choi","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.autrev.2026.104072_bb0495","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15020445","article-title":"Dexamethasone-induced fatty acid oxidation and autophagy\/mitophagy are essential for T-ALL glucocorticoid resistance","volume":"15","author":"Olivas-Aguirre","year":"2023","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.autrev.2026.104072_bb0500","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1136\/ard-2022-223356","article-title":"EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2022 update","volume":"82","author":"Smolen","year":"2023","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2026.104072_bb0505","doi-asserted-by":"crossref","first-page":"e517","DOI":"10.1016\/S2665-9913(21)00009-6","article-title":"The Asia-Pacific league of associations for rheumatology consensus statements on the management of systemic lupus erythematosus","volume":"3","author":"Mok","year":"2021","journal-title":"Lancet Rheumatol"},{"key":"10.1016\/j.autrev.2026.104072_bb0510","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105582","article-title":"Chloroquine and hydroxychloroquine in antitumor therapies based on autophagy-related mechanisms","volume":"168","author":"Ferreira","year":"2021","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.autrev.2026.104072_bb0515","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/s41584-020-0372-x","article-title":"Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology","volume":"16","author":"Schrezenmeier","year":"2020","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.autrev.2026.104072_bb0520","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.ymthe.2024.04.010","article-title":"DRP1 bridges complement component C5a and podocyte injury in lupus nephritis","volume":"32","author":"Lei","year":"2024","journal-title":"Mol Ther"},{"key":"10.1016\/j.autrev.2026.104072_bb0525","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1136\/annrheumdis-2013-203794","article-title":"HRES-1\/Rab4-mediated depletion of Drp1 impairs mitochondrial homeostasis and represents a target for treatment in SLE","volume":"73","author":"Caza","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.autrev.2026.104072_bb0530","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s12974-019-1542-0","article-title":"Mdivi-1, a mitochondrial fission inhibitor, modulates T helper cells and suppresses the development of experimental autoimmune encephalomyelitis","volume":"16","author":"Li","year":"2019","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.autrev.2026.104072_bb0535","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1002\/dneu.22519","article-title":"To mdivi-1 or not to mdivi-1: is that the question?","volume":"77","author":"Smith","year":"2017","journal-title":"Dev Neurobiol"},{"key":"10.1016\/j.autrev.2026.104072_bb0540","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-69748-y","article-title":"Detailed analysis of Mdivi-1 effects on complex I and respiratory supercomplex assembly","volume":"14","author":"Marx","year":"2024","journal-title":"Sci Rep"},{"key":"10.1016\/j.autrev.2026.104072_bb0545","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1186\/s13287-024-03928-5","article-title":"Adipose stem cell exosomes promote mitochondrial autophagy through the PI3K\/AKT\/mTOR pathway to alleviate keloids","volume":"15","author":"Liu","year":"2024","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.autrev.2026.104072_bb0550","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1080\/15548627.2024.2437908","article-title":"Inhibition of the PI3K-AKT-MTORC1 axis reduces the burden of the m.3243A>G mtDNA mutation by promoting mitophagy and improving mitochondrial function","volume":"21","author":"Chung","year":"2025","journal-title":"Autophagy"},{"key":"10.1016\/j.autrev.2026.104072_bb0555","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26020806","article-title":"Autophagy and mitophagy in diabetic kidney disease-a literature review","volume":"26","author":"Stanigut","year":"2025","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.autrev.2026.104072_bb0560","doi-asserted-by":"crossref","first-page":"4278","DOI":"10.7150\/thno.96038","article-title":"Stimulation by exosomes from hypoxia-preconditioned hair follicle mesenchymal stem cells facilitates mitophagy by inhibiting the PI3K\/AKT\/mTOR signaling pathway to alleviate ulcerative colitis","volume":"14","author":"Li","year":"2024","journal-title":"Theranostics"},{"key":"10.1016\/j.autrev.2026.104072_bb0565","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/nchembio.1735","article-title":"Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation","volume":"11","author":"Lewis","year":"2015","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.autrev.2026.104072_bb0570","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.124729","article-title":"Peptidylarginine deiminases 2 and 4 modulate innate and adaptive immune responses in TLR-7-dependent lupus","volume":"3","author":"Liu","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.autrev.2026.104072_bb0575","article-title":"DNase I alleviates renal inflammatory injury in MRL\/lpr mice by inhibiting NETs formation","volume":"16","author":"Zhang","year":"2025","journal-title":"Front Immunol"},{"key":"10.1016\/j.autrev.2026.104072_bb0580","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2021.103314","article-title":"A STING antagonist modulating the interaction with STIM1 blocks ER-to-Golgi trafficking and inhibits lupus pathology","volume":"66","author":"Prabakaran","year":"2021","journal-title":"EBioMedicine"},{"key":"10.1016\/j.autrev.2026.104072_bb0585","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1186\/s12964-024-01989-w","article-title":"New insights into the role of mitophagy related gene affecting the metastasis of osteosarcoma through scRNA-seq and CRISPR-Cas9 genome editing","volume":"22","author":"Zheng","year":"2024","journal-title":"Cell Commun Signal"},{"key":"10.1016\/j.autrev.2026.104072_bb0590","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.apsb.2024.12.008","article-title":"Nanoengineered cargo with targeted in vivo Foxo3 gene editing modulated mitophagy of chondrocytes to alleviate osteoarthritis","volume":"15","author":"Chen","year":"2025","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.autrev.2026.104072_bb0595","doi-asserted-by":"crossref","first-page":"8644","DOI":"10.1021\/acs.nanolett.5c01495","article-title":"A nanosystem alleviates severe acute pancreatitis via reactive oxygen species scavenging and enhancing mitochondrial autophagy","volume":"25","author":"Wang","year":"2025","journal-title":"Nano Lett"},{"key":"10.1016\/j.autrev.2026.104072_bb0600","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1177\/09612033241247622","article-title":"Extracellular mitochondrial components as new biomarkers for lupus nephritis","volume":"33","author":"Gowda","year":"2024","journal-title":"Lupus"},{"key":"10.1016\/j.autrev.2026.104072_bb0605","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/nm.4027","article-title":"Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease","volume":"22","author":"Lood","year":"2016","journal-title":"Nat Med"},{"key":"10.1016\/j.autrev.2026.104072_bb0610","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2025.1585847","article-title":"Mitochondrial mass and mitochondrial membrane potential of peripheral lymphocytes: promising biomarkers of systemic lupus erythematosus","volume":"12","author":"Zhao","year":"2025","journal-title":"Front Mol Biosci"}],"container-title":["Autoimmunity Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568997226000868?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568997226000868?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T07:20:34Z","timestamp":1783149634000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568997226000868"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":122,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S1568997226000868"],"URL":"https:\/\/doi.org\/10.1016\/j.autrev.2026.104072","relation":{},"ISSN":["1568-9972"],"issn-type":[{"value":"1568-9972","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of mitophagy in systemic lupus erythematosus","name":"articletitle","label":"Article Title"},{"value":"Autoimmunity Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.autrev.2026.104072","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104072"}}