{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T20:25:53Z","timestamp":1793737553164,"version":"4.6.1"},"reference-count":203,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Autoimmunity Reviews"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.autrev.2026.104208","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:19:09Z","timestamp":1792595949000},"page":"104208","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mitochondrial DNA mediated Kupffer cell activation in the pathogenesis and progression of liver diseases"],"prefix":"10.1016","volume":"26","author":[{"given":"Zijun","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luqing","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjun","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.autrev.2026.104208_bb0005","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/s41577-026-01288-0","article-title":"KCs in liver homeostasis and disease: from immune sentinels to metabolic gatekeepers","volume":"26","author":"Araujo David","year":"2026","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.autrev.2026.104208_bb0010","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/imm.13193","article-title":"The liver as an immunological barrier redefined by single-cell analysis","volume":"160","author":"Stamataki","year":"2020","journal-title":"Immunology"},{"issue":"2","key":"10.1016\/j.autrev.2026.104208_bb0015","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.immuni.2025.01.002","article-title":"Spatially restricted and ontogenically distinct hepatic macrophages are required for tissue repair","volume":"58","author":"De Ponti","year":"2025","journal-title":"Immunity"},{"key":"10.1016\/j.autrev.2026.104208_bb0020","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nature08780","article-title":"Circulating mitochondrial DAMPs cause inflammatory responses to injury","volume":"464","author":"Zhang","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.autrev.2026.104208_bb0025","article-title":"Mitochondrial DNA editing: key to the treatment of neurodegenerative diseases","volume":"12","author":"Hong","year":"2024","journal-title":"Genes Dis"},{"key":"10.1016\/j.autrev.2026.104208_bb0030","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22168523","article-title":"Mitochondria-induced immune response as a trigger for neurodegeneration: a pathogen from within","volume":"22","author":"Luna-S\u00e1nchez","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.autrev.2026.104208_bb0035","doi-asserted-by":"crossref","DOI":"10.3390\/cells11121894","article-title":"RIP3 translocation into mitochondria promotes mitofilin degradation to increase inflammation and kidney injury after renal ischemia-reperfusion","volume":"11","author":"Feng","year":"2022","journal-title":"Cells"},{"issue":"2","key":"10.1016\/j.autrev.2026.104208_bb0040","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s10741-020-10031-3","article-title":"Barth syndrome cardiomyopathy: targeting the mitochondria with elamipretide","volume":"26","author":"Sabbah","year":"2021","journal-title":"Heart Fail Rev"},{"key":"10.1016\/j.autrev.2026.104208_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e16377","article-title":"Phytochemical profiling, antioxidant potential and protective effect of leaves extract of tunisian Vitis vinifera autochthonous accessions against acute CCl4-injured hepatotoxicity in mice","volume":"9","author":"Saadaoui","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.autrev.2026.104208_bb0050","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s12935-023-02916-8","article-title":"Colorectal cancer-derived small extracellular vesicles induce TGF\u03b21-mediated epithelial to mesenchymal transition of hepatocytes","volume":"23","author":"Pucci","year":"2023","journal-title":"Cancer Cell Int"},{"key":"10.1016\/j.autrev.2026.104208_bb0055","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/cmi.2015.111","article-title":"CD205-TLR9-IL-12 axis contributes to CpG-induced oversensitive liver injury in HBsAg transgenic mice by promoting the interaction of NKT cells with KCs","volume":"14","author":"Hou","year":"2017","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.autrev.2026.104208_bb0060","doi-asserted-by":"crossref","DOI":"10.3390\/cells6040048","article-title":"Differential location and distribution of hepatic immune cells","volume":"6","author":"Freitas-Lopes","year":"2017","journal-title":"Cells"},{"key":"10.1016\/j.autrev.2026.104208_bb0065","first-page":"845","article-title":"The mononuclear phagocyte system: a new classification of macrophages, monocytes, and their precursor cells","volume":"46","author":"van Furth","year":"1972","journal-title":"Bull World Health Organ"},{"key":"10.1016\/j.autrev.2026.104208_bb0070","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/s41586-019-1373-2","article-title":"A human liver cell atlas reveals heterogeneity and epithelial progenitors","volume":"572","author":"Aizarani","year":"2019","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.autrev.2026.104208_bb0075","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.immuni.2019.08.017","article-title":"Stellate cells, hepatocytes, and endothelial cells imprint the Kupffer cell identity on monocytes colonizing the liver macrophage niche","volume":"51","author":"Bonnardel","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.autrev.2026.104208_bb0080","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1038\/s41423-025-01298-3","article-title":"Liver macrophages: development, dynamics, and functions","volume":"22","author":"Nusse","year":"2025","journal-title":"Cell Mol Immunol"},{"issue":"4","key":"10.1016\/j.autrev.2026.104208_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.immuni.2019.09.002","article-title":"Liver-derived signals sequentially reprogram myeloid enhancers to initiate and maintain Kupffer cell identity","volume":"51","author":"Sakai","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.autrev.2026.104208_bb0090","article-title":"Macrophage heterogeneity in liver fibrosis","volume":"16","author":"Wang","year":"2025","journal-title":"Front Immunol"},{"key":"10.1016\/j.autrev.2026.104208_bb0095","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms10321","article-title":"Bone marrow-derived monocytes give rise to self-renewing and fully differentiated KCs","volume":"7","author":"Scott","year":"2016","journal-title":"Nat Commun"},{"issue":"10","key":"10.1016\/j.autrev.2026.104208_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113164","article-title":"Monocyte-derived KCs dominate in the Kupffer cell pool during liver injury","volume":"42","author":"Li","year":"2023","journal-title":"Cell Rep"},{"key":"10.1016\/j.autrev.2026.104208_bb0105","article-title":"Heterogeneity and function of KCs in Liver Injury","volume":"13","author":"Li","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.autrev.2026.104208_bb0110","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.00322","article-title":"Hepatic macrophages in liver injury","volume":"11","author":"Shan","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.autrev.2026.104208_bb0115","article-title":"Susceptibility to infections during acute liver injury depends on transient disruption of liver macrophage niche","volume":"13","author":"Lopes","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.autrev.2026.104208_bb0120","doi-asserted-by":"crossref","first-page":"6166","DOI":"10.4049\/jimmunol.164.12.6166","article-title":"M-1\/M-2 macrophages and the Th1\/Th2 paradigm","volume":"164","author":"Mills","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2026.104208_bb0125","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1084\/jem.116.3.381","article-title":"Cellular resistance to infection","volume":"116","author":"Mackaness","year":"1962","journal-title":"J Exp Med"},{"key":"10.1016\/j.autrev.2026.104208_bb0130","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1002\/j.2040-4603.2013.tb00510.x","article-title":"KCs in the liver","volume":"3","author":"Dixon","year":"2013","journal-title":"Compr Physiol"},{"key":"10.1016\/j.autrev.2026.104208_bb0135","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1172\/JCI59643","article-title":"Macrophage plasticity and polarization: in vivo veritas","volume":"122","author":"Sica","year":"2012","journal-title":"J Clin Invest"},{"key":"10.1016\/j.autrev.2026.104208_bb0140","doi-asserted-by":"crossref","first-page":"6425","DOI":"10.1002\/jcp.26429","article-title":"Macrophage plasticity, polarization, and function in health and disease","volume":"233","author":"Shapouri-Moghaddam","year":"2018","journal-title":"J Cell Physiol"},{"issue":"1","key":"10.1016\/j.autrev.2026.104208_bb0145","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","article-title":"Macrophage activation and polarization: nomenclature and experimental guidelines","volume":"41","author":"Murray","year":"2014","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.autrev.2026.104208_bb0150","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41423-020-00558-8","article-title":"Hepatic macrophages in liver homeostasis and diseases-diversity, plasticity and therapeutic opportunities","volume":"18","author":"Wen","year":"2021","journal-title":"Cell Mol Immunol"},{"issue":"2","key":"10.1016\/j.autrev.2026.104208_bb0155","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.immuni.2014.01.006","article-title":"Transcriptome-based network analysis reveals a spectrum model of human macrophage activation","volume":"40","author":"Xue","year":"2014","journal-title":"Immunity"},{"issue":"7783","key":"10.1016\/j.autrev.2026.104208_bb0160","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/s41586-019-1631-3","article-title":"Resolving the fibrotic niche of human liver cirrhosis at single-cell level","volume":"575","author":"Ramachandran","year":"2019","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.autrev.2026.104208_bb0165","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.immuni.2020.04.001","article-title":"Niche-specific reprogramming of epigenetic landscapes drives myeloid cell diversity in nonalcoholic steatohepatitis","volume":"52","author":"Seidman","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.autrev.2026.104208_bb0170","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/nrm3877","article-title":"Mitochondrial dynamics and inheritance during cell division, development and disease","volume":"15","author":"Mishra","year":"2014","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.autrev.2026.104208_bb0175","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/7157109","article-title":"mtDNA in the pathogenesis of cardiovascular diseases","volume":"2021","author":"Wang","year":"2021","journal-title":"Dis Markers"},{"key":"10.1016\/j.autrev.2026.104208_bb0180","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1126\/science.1156906","article-title":"ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis","volume":"320","author":"Ishikawa","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.autrev.2026.104208_bb0185","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1126\/science.1112125","article-title":"Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging","volume":"309","author":"Kujoth","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.autrev.2026.104208_bb0190","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14061452","article-title":"Mitochondrial DNA on tumor-associated macrophages polarization and immunity","volume":"14","author":"Guo","year":"2022","journal-title":"Cancers (Basel)"},{"issue":"3","key":"10.1016\/j.autrev.2026.104208_bb0195","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.immuni.2020.02.002","article-title":"mtDNA activates cGAS signaling and suppresses the YAP-mediated endothelial cell proliferation program to promote inflammatory injury","volume":"52","author":"Huang","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.autrev.2026.104208_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102367","article-title":"STING signaling sensing of DRP1-dependent mtDNA release in KCs contributes to lipopolysaccharide-induced liver injury in mice","volume":"54","author":"Zhang","year":"2022","journal-title":"Redox Biol"},{"key":"10.1016\/j.autrev.2026.104208_bb0205","doi-asserted-by":"crossref","first-page":"14782","DOI":"10.1073\/pnas.1417253111","article-title":"Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome c release during apoptosis","volume":"111","author":"Jiang","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.autrev.2026.104208_bb0210","doi-asserted-by":"crossref","DOI":"10.1126\/science.aao6047","article-title":"BAK\/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis","volume":"359","author":"McArthur","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.autrev.2026.104208_bb0215","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1146\/annurev-biochem-032620-104401","article-title":"Mitochondrial DNA release in innate immune signaling","volume":"92","author":"Newman","year":"2023","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.autrev.2026.104208_bb0220","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1126\/science.aav4011","article-title":"VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease","volume":"366","author":"Kim","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.autrev.2026.104208_bb0225","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1002\/cbin.11427","article-title":"VDAC oligomer pores: a mechanism in disease triggered by mtDNA release","volume":"44","author":"Yan","year":"2020","journal-title":"Cell Biol Int"},{"key":"10.1016\/j.autrev.2026.104208_bb0230","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.yjmcc.2009.02.007","article-title":"The molecular composition of the mitochondrial permeability transition pore","volume":"46","author":"Baines","year":"2009","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.autrev.2026.104208_bb0235","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1152\/physrev.00024.2007","article-title":"Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury","volume":"88","author":"Murphy","year":"2008","journal-title":"Physiol Rev"},{"key":"10.1016\/j.autrev.2026.104208_bb0240","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0300-9084(02)01375-5","article-title":"The permeability transition pore complex: another view","volume":"84","author":"Halestrap","year":"2002","journal-title":"Biochimie"},{"key":"10.1016\/j.autrev.2026.104208_bb0245","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2024.1370042","article-title":"TRIF-dependent signaling and its role in liver diseases","volume":"12","author":"Hu","year":"2024","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.autrev.2026.104208_bb0250","doi-asserted-by":"crossref","DOI":"10.1093\/jmcb\/mjac005","article-title":"Intervention of cGAS\u2013STING signaling in sterile inflammatory diseases","volume":"14","author":"Hong","year":"2022","journal-title":"J Mol Cell Biol"},{"key":"10.1016\/j.autrev.2026.104208_bb0255","doi-asserted-by":"crossref","first-page":"G655","DOI":"10.1152\/ajpgi.00326.2017","article-title":"cGAS-mediated autophagy protects the liver from ischemia-reperfusion injury independently of STING","volume":"314","author":"Lei","year":"2018","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.autrev.2026.104208_bb0260","article-title":"Mitochondrial DNA in atherosclerosis: mechanisms, biomarker potential, and therapeutic perspectives","volume":"148","author":"Zhang","year":"2025","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.autrev.2026.104208_bb0265","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241512012","article-title":"Mitochondrial dysfunction associated with mtDNA in metabolic syndrome and obesity","volume":"24","author":"Todosenko","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.autrev.2026.104208_bb0270","doi-asserted-by":"crossref","first-page":"578","DOI":"10.2174\/1570159X20666220810114644","article-title":"mtDNA maintenance and alterations in the pathogenesis of neurodegenerative diseases","volume":"21","author":"Shang","year":"2023","journal-title":"Curr Neuropharmacol"},{"key":"10.1016\/j.autrev.2026.104208_bb0275","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.796066","article-title":"Role of mitochondrial nucleic acid sensing pathways in health and patho-physiology","volume":"10","author":"Chowdhury","year":"2022","journal-title":"Front Cell Dev Biol"},{"issue":"22","key":"10.1016\/j.autrev.2026.104208_bb0280","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252212168","article-title":"Mitochondria-targeted DNA repair glycosylase hOGG1 protects against HFD-induced liver oxidative mitochondrial DNA damage and insulin resistance in OGG1-deficient mice","volume":"25","author":"Yuzefovych","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.autrev.2026.104208_bb0285","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s42255-022-00711-9","article-title":"Cytosolic aldose metabolism contributes to progression from cirrhosis to hepatocarcinogenesis","volume":"5","author":"Oaks","year":"2023","journal-title":"Nat Metab"},{"key":"10.1016\/j.autrev.2026.104208_bb0290","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/5835910","article-title":"A potential role for mitochondrial DNA in the activation of oxidative stress and inflammation in liver disease","volume":"2020","author":"Xuan","year":"2020","journal-title":"Oxidative Med Cell Longev"},{"issue":"3","key":"10.1016\/j.autrev.2026.104208_bb0295","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.immuni.2012.01.009","article-title":"Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis","volume":"36","author":"Shimada","year":"2012","journal-title":"Immunity"},{"issue":"8","key":"10.1016\/j.autrev.2026.104208_bb0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.immuni.2022.06.007","article-title":"Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling","volume":"55","author":"Xian","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.autrev.2026.104208_bb0305","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1038\/s41590-025-02179-7","article-title":"Mitochondrial DNA oxidation propagates autoimmunity by enabling plasmacytoid dendritic cells to induce TFH differentiation","volume":"26","author":"Xian","year":"2025","journal-title":"Nat Immunol"},{"key":"10.1016\/j.autrev.2026.104208_bb0310","doi-asserted-by":"crossref","DOI":"10.1038\/s41420-025-02746-9","article-title":"Aging aggravated liver ischemia and reperfusion injury by promoting oxidized mtDNA mediated-macrophage pyroptosis through acetylated MCU-dependent calcium uptake","volume":"11","author":"Wu","year":"2025","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.autrev.2026.104208_bb0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2023.103112","article-title":"mTOR-dependent loss of PON1 secretion and antiphospholipid autoantibody production underlie autoimmunity-mediated cirrhosis in transaldolase deficiency","volume":"140","author":"Winans","year":"2023","journal-title":"J Autoimmun"},{"issue":"5","key":"10.1016\/j.autrev.2026.104208_bb0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2025.103781","volume":"24","author":"Banki","year":"2025","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.autrev.2026.104208_bb0325","doi-asserted-by":"crossref","DOI":"10.1038\/s41584-026-01421-2","article-title":"Hepatic control of immunometabolism: implications for the pathogenesis, diagnosis and treatment of rheumatic diseases","author":"Perl","year":"2026","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.autrev.2026.104208_bb0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102305","article-title":"XBP1 deficiency promotes hepatocyte pyroptosis by impairing mitophagy to activate mtDNA-cGAS-STING signaling in macrophages during acute liver injury","volume":"52","author":"Liu","year":"2022","journal-title":"Redox Biol"},{"key":"10.1016\/j.autrev.2026.104208_bb0335","doi-asserted-by":"crossref","first-page":"16427","DOI":"10.2147\/JIR.S549406","article-title":"Novel perspectives in hepatic ischemia-reperfusion injury: the cGAS-STING pathway","volume":"18","author":"Chen","year":"2025","journal-title":"J Inflamm Res"},{"key":"10.1016\/j.autrev.2026.104208_bb0340","article-title":"A new insight: crosstalk between neutrophil extracellular traps and the gut-liver axis for nonalcoholic fatty liver disease","volume":"16","author":"Yin","year":"2025","journal-title":"Front Immunol"},{"key":"10.1016\/j.autrev.2026.104208_bb0345","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.2337\/dbi18-0052","article-title":"The cGAS-cGAMP-STING pathway: a molecular link between immunity and metabolism","volume":"68","author":"Bai","year":"2019","journal-title":"Diabetes"},{"key":"10.1016\/j.autrev.2026.104208_bb0350","doi-asserted-by":"crossref","first-page":"5975","DOI":"10.1038\/s41598-024-80903-3","article-title":"Clusterin inhibits lipopolysaccharide induced liver injury","volume":"15","author":"Seo","year":"2025","journal-title":"Sci Rep"},{"key":"10.1016\/j.autrev.2026.104208_bb0355","doi-asserted-by":"crossref","first-page":"474","DOI":"10.37349\/edd.2024.00062","article-title":"Mitochondrial ROS, a trigger for mitochondrial dysfunction and inflammasome activation and a therapeutic target in liver diseases","volume":"3","author":"Jaara","year":"2024","journal-title":"Explor Dig Dis"},{"key":"10.1016\/j.autrev.2026.104208_bb0360","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","article-title":"The NLRP3 inflammasome: molecular activation and regulation to therapeutics","volume":"19","author":"Swanson","year":"2019","journal-title":"Nat Rev Immunol"},{"issue":"3","key":"10.1016\/j.autrev.2026.104208_bb0365","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.immuni.2013.08.004","article-title":"Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing","volume":"39","author":"Gehrke","year":"2013","journal-title":"Immunity"},{"issue":"14","key":"10.1016\/j.autrev.2026.104208_bb0370","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.1016\/j.cell.2023.05.039","article-title":"Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity","volume":"186","author":"Lei","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.autrev.2026.104208_bb0375","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2525296122","article-title":"Identification of an IRF-ZBP1-caspase-8-NINJ1 axis in driving PANoptosis and pathology during alcohol-associated liver disease","volume":"122","author":"Qin","year":"2025","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.autrev.2026.104208_bb0380","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1161\/CIRCRESAHA.122.322227","article-title":"ZBP1 protects against mtDNA-induced myocardial inflammation in failing hearts","volume":"132","author":"Enzan","year":"2023","journal-title":"Circ Res"},{"key":"10.1016\/j.autrev.2026.104208_bb0385","doi-asserted-by":"crossref","first-page":"652","DOI":"10.3350\/cmh.2020.0160","article-title":"Global and regional impacts of alcohol use on public health: Emphasis on alcohol policies","volume":"26","author":"Park","year":"2020","journal-title":"Clin Mol Hepatol"},{"key":"10.1016\/j.autrev.2026.104208_bb0390","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.cld.2012.08.002","article-title":"Alcohol metabolism","volume":"16","author":"Cederbaum","year":"2012","journal-title":"Clin Liver Dis"},{"key":"10.1016\/j.autrev.2026.104208_bb0395","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1016\/S0140-6736(09)60746-7","article-title":"Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders","volume":"373","author":"Rehm","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.autrev.2026.104208_bb0400","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nrgastro.2015.35","article-title":"Alcoholic liver disease: mechanisms of injury and targeted treatment","volume":"12","author":"Louvet","year":"2015","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.autrev.2026.104208_bb0405","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.jhep.2018.05.001","article-title":"Grand rounds: alcoholic hepatitis","volume":"69","author":"Singal","year":"2018","journal-title":"J Hepatol"},{"key":"10.1016\/j.autrev.2026.104208_bb0410","doi-asserted-by":"crossref","DOI":"10.1186\/s12967-023-04166-8","article-title":"Pathogenic mechanisms and regulatory factors involved in alcoholic liver disease","volume":"21","author":"Yan","year":"2023","journal-title":"J Transl Med"},{"key":"10.1016\/j.autrev.2026.104208_bb0415","first-page":"G951","article-title":"Use of measurements of ethanol absorption from stomach and intestine to assess human ethanol metabolism","volume":"273","author":"Levitt","year":"1997","journal-title":"Am J Phys"},{"issue":"6 Suppl","key":"10.1016\/j.autrev.2026.104208_bb0420","article-title":"Kupffer cell sensitization by alcohol involves increased permeability to gut-derived endotoxin","volume":"25","author":"Enomoto","year":"2001","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.autrev.2026.104208_bb0425","article-title":"Microbial treatment of alcoholic liver disease: a systematic review and meta-analysis","volume":"9","author":"Wang","year":"2022","journal-title":"Front Nutr"},{"key":"10.1016\/j.autrev.2026.104208_bb0430","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232113085","article-title":"Aging of liver in its different diseases","volume":"23","author":"Radonji\u0107","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.autrev.2026.104208_bb0435","article-title":"A meta-analysis of preclinical studies to investigate the effect of Panax ginseng on alcohol-associated liver disease","volume":"12","author":"Yang","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.autrev.2026.104208_bb0440","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3390\/biomedicines6040106","article-title":"Alcoholic liver disease: alcohol metabolism, cascade of molecular mechanisms, cellular targets, and clinical aspects","volume":"6","author":"Teschke","year":"2018","journal-title":"Biomedicines"},{"key":"10.1016\/j.autrev.2026.104208_bb0445","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/978-1-4684-4661-6_9","article-title":"Alcohol-induced mitochondrial changes in the liver","volume":"2","author":"Gordon","year":"1984","journal-title":"Recent Dev Alcohol"},{"key":"10.1016\/j.autrev.2026.104208_bb0450","first-page":"61","article-title":"Effect of ethanol intake on rat liver mitochondrial respiration and oxidative phosphorylation","volume":"14","author":"Wei","year":"1990","journal-title":"Proc Natl Sci Counc Repub China B"},{"key":"10.1016\/j.autrev.2026.104208_bb0455","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222413384","article-title":"Mitochondrial oxidative stress-a causative factor and therapeutic target in many diseases","volume":"22","author":"Kowalczyk","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.autrev.2026.104208_bb0460","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.3748\/wjg.v20.i9.2136","article-title":"Role of mitochondria in alcoholic liver disease","volume":"20","author":"Nassir","year":"2014","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.autrev.2026.104208_bb0465","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2016.00107","article-title":"Mitochondria know no boundaries: mechanisms and functions of intercellular mitochondrial transfer","volume":"4","author":"Torralba","year":"2016","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.autrev.2026.104208_bb0470","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.92634","article-title":"Mitochondrial DNA-enriched microparticles promote acute-on-chronic alcoholic neutrophilia and hepatotoxicity","volume":"2","author":"Cai","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.autrev.2026.104208_bb0475","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1002\/hep.21867","article-title":"Apoptotic hepatocyte DNA inhibits hepatic stellate cell chemotaxis via toll-like receptor 9","volume":"46","author":"Watanabe","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.autrev.2026.104208_bb0480","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.jhep.2019.06.018","article-title":"ALDH2 deficiency promotes alcohol-associated liver cancer by activating oncogenic pathways via oxidized DNA-enriched extracellular vesicles","volume":"71","author":"Seo","year":"2019","journal-title":"J Hepatol"},{"issue":"15","key":"10.1016\/j.autrev.2026.104208_bb0485","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aea3979","article-title":"Innate immune sensing of dietary alcohol ignites inflammation to drive alcohol-related disease","volume":"12","author":"Jang","year":"2026","journal-title":"Sci Adv"},{"key":"10.1016\/j.autrev.2026.104208_bb0490","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/hep.24018","article-title":"Enteric dysbiosis associated with a mouse model of alcoholic liver disease","volume":"53","author":"Yan","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.autrev.2026.104208_bb0495","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1002\/hep.23009","article-title":"Endotoxemia and gut barrier dysfunction in alcoholic liver disease","volume":"50","author":"Rao","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.autrev.2026.104208_bb0500","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1007\/s00018-020-03656-y","article-title":"TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling","volume":"78","author":"Ciesielska","year":"2021","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.autrev.2026.104208_bb0505","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s00018-024-05221-3","article-title":"Flotillins affect LPS-induced TLR4 signaling by modulating the trafficking and abundance of CD14","volume":"81","author":"Matveichuk","year":"2024","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.autrev.2026.104208_bb0510","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/978-1-4757-9966-8_25","article-title":"CD14 is expressed by subsets of murine dendritic cells and upregulated by lipopolysaccharide","volume":"417","author":"Mahnke","year":"1997","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.autrev.2026.104208_bb0515","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-53670-y","article-title":"Biosynthetic enzyme analysis identifies a protective role for TLR4-acting gut microbial sulfonolipids in inflammatory bowel disease","volume":"15","author":"Older","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.autrev.2026.104208_bb0520","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s12072-010-9219-x","article-title":"The role of lipopolysaccharide\/toll-like receptor 4 signaling in chronic liver diseases","volume":"4","author":"Soares","year":"2010","journal-title":"Hepatol Int"},{"key":"10.1016\/j.autrev.2026.104208_bb0525","doi-asserted-by":"crossref","first-page":"e408","DOI":"10.1038\/emm.2017.207","article-title":"Hepatocyte toll-like receptor 4 mediates lipopolysaccharide-induced hepcidin expression","volume":"49","author":"Lee","year":"2017","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.autrev.2026.104208_bb0530","article-title":"The interaction of MD-2 with small molecules in huanglian jiedu decoction play a critical role in the treatment of sepsis","volume":"13","author":"Chen","year":"2022","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.autrev.2026.104208_bb0535","doi-asserted-by":"crossref","first-page":"558","DOI":"10.4049\/jimmunol.1502098","article-title":"Cutting edge: ezrin regulates inflammation by limiting B cell IL-10 production","volume":"196","author":"ore","year":"2016","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2026.104208_bb0540","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1002\/hep.22470","article-title":"The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88","volume":"48","author":"Hritz","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.autrev.2026.104208_bb0545","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0051243","article-title":"A critical role for MAPK signalling pathways in the transcriptional regulation of toll like receptors","volume":"8","author":"Peroval","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.autrev.2026.104208_bb0550","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2100225118","article-title":"TBK1 recruitment to STING activates both IRF3 and NF-\u03baB that mediate immune defense against tumors and viral infections","volume":"118","author":"Yum","year":"2021","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.autrev.2026.104208_bb0555","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/s41581-022-00589-6","article-title":"Role of the cGAS-STING pathway in systemic and organ-specific diseases","volume":"18","author":"Skopelja-Gardner","year":"2022","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.autrev.2026.104208_bb0560","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/s41577-021-00524-z","article-title":"The cGAS-STING pathway as a therapeutic target in inflammatory diseases","volume":"21","author":"Decout","year":"2021","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.autrev.2026.104208_bb0565","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/j.cell.2014.11.037","article-title":"Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA","volume":"159","author":"Rongvaux","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.autrev.2026.104208_bb0570","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1042\/BST20221525","article-title":"Mitochondrial DNA in cell death and inflammation","volume":"51","author":"Heilig","year":"2023","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.autrev.2026.104208_bb0575","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.120874","article-title":"TLR9: a friend or a foe","volume":"307","author":"Saber","year":"2022","journal-title":"Life Sci"},{"key":"10.1016\/j.autrev.2026.104208_bb0580","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.molmed.2007.09.002","article-title":"Signaling to NF-kappaB by Toll-like receptors","volume":"13","author":"Kawai","year":"2007","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.autrev.2026.104208_bb0585","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/imr.12302","article-title":"Tumor necrosis factor receptor-associated factor 6 (TRAF6) regulation of development, function, and homeostasis of the immune system","volume":"266","author":"Walsh","year":"2015","journal-title":"Immunol Rev"},{"key":"10.1016\/j.autrev.2026.104208_bb0590","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1080\/13510002.2021.1891808","article-title":"Contribution of oxidative stress in the mechanisms of postoperative complications and multiple organ dysfunction syndrome","volume":"26","author":"Toro-P\u00e9rez","year":"2021","journal-title":"Redox Rep"},{"key":"10.1016\/j.autrev.2026.104208_bb0595","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S2468-1253(22)00165-0","article-title":"The prevalence and incidence of MASLD worldwide: a systematic review and meta-analysis","volume":"7","author":"Riazi","year":"2022","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.autrev.2026.104208_bb0600","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.jhep.2018.05.036","article-title":"Modeling MASLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016-2030","volume":"69","author":"Estes","year":"2018","journal-title":"J Hepatol"},{"key":"10.1016\/j.autrev.2026.104208_bb0605","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/s41577-021-00639-3","article-title":"Immune cell-mediated features of non-alcoholic steatohepatitis","volume":"22","author":"Huby","year":"2022","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.autrev.2026.104208_bb0610","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1172\/JCI88881","article-title":"Liver inflammation and fibrosis","volume":"127","author":"Koyama","year":"2017","journal-title":"J Clin Invest"},{"key":"10.1016\/j.autrev.2026.104208_bb0615","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1002\/hep.30506","article-title":"The role of innate immune cells in nonalcoholic steatohepatitis","volume":"70","author":"Cai","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.autrev.2026.104208_bb0620","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1080\/17474124.2021.1887730","article-title":"Hepatocyte and immune cell crosstalk in non-alcoholic fatty liver disease","volume":"15","author":"Carranza-Trejo","year":"2021","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.autrev.2026.104208_bb0625","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.bbrc.2018.12.149","article-title":"Liraglutide protects against inflammatory stress in non-alcoholic fatty liver by modulating KCs M2 polarization via cAMP-PKA-STAT3 signaling pathway","volume":"510","author":"Li","year":"2019","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.autrev.2026.104208_bb0630","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1199519","article-title":"Activation of KCs in MASLD and MASH: mechanisms and therapeutic interventions","volume":"11","author":"Xu","year":"2023","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.autrev.2026.104208_bb0635","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1172\/JCI34260","article-title":"Insulin sensitivity: modulation by nutrients and inflammation","volume":"118","author":"Schenk","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1016\/j.autrev.2026.104208_bb0640","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aar2680","article-title":"An optical nanoreporter of endolysosomal lipid accumulation reveals enduring effects of diet on hepatic macrophages in vivo","volume":"10","author":"Galassi","year":"2018","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.autrev.2026.104208_bb0645","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.7150\/ijbs.107777","article-title":"The role of mitochondrial quality control in liver diseases: dawn of a therapeutic era","volume":"21","author":"Li","year":"2025","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.autrev.2026.104208_bb0650","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1053\/j.gastro.2018.06.083","article-title":"Mitochondrial dysfunction and signaling in chronic liver diseases","volume":"155","author":"Mansouri","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.autrev.2026.104208_bb0655","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1053\/j.gastro.2005.02.001","article-title":"Mice heterozygous for a defect in mitochondrial trifunctional protein develop hepatic steatosis and insulin resistance","volume":"128","author":"Ibdah","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.autrev.2026.104208_bb0660","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2023.155663","article-title":"Uroguanylin prevents hepatic steatosis, mitochondrial dysfunction and fibrosis in obesity-associated NAFLD","volume":"147","author":"Fern\u00e1ndez-S\u00e1ez","year":"2023","journal-title":"Metabolism"},{"key":"10.1016\/j.autrev.2026.104208_bb0665","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.freeradbiomed.2026.03.017","article-title":"FNDC4 regulates TGF-\u03b21-induced hepatic stellate cell activation and liver fibrosis via the AMPK\/YAP pathway","volume":"249","author":"Neira","year":"2026","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.autrev.2026.104208_bb0670","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1002\/hep.1840380426","article-title":"Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis","volume":"38","author":"P\u00e9rez-Carreras","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.autrev.2026.104208_bb0675","doi-asserted-by":"crossref","first-page":"40161","DOI":"10.1074\/jbc.M112.417014","article-title":"Kuppfer cells trigger nonalcoholic steatohepatitis development in diet-induced mouse model through tumor necrosis factor-\u03b1 production","volume":"287","author":"Tosello-Trampont","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1016\/j.autrev.2026.104208_bb0680","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.jcmgh.2024.01.009","article-title":"Oral supplementation of phosphatidylcholine attenuates the onset of a diet-induced metabolic dysfunction-associated steatohepatitis in female C57BL\/6J mice","volume":"17","author":"S\u00e1nchez","year":"2024","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.autrev.2026.104208_bb0685","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/s41575-018-0082-x","article-title":"The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis","volume":"16","author":"Kazankov","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.autrev.2026.104208_bb0690","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.jcmgh.2016.12.004","article-title":"TRIF differentially regulates hepatic steatosis and inflammation\/fibrosis in mice","volume":"3","author":"YYang","year":"2017","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.autrev.2026.104208_bb0695","article-title":"The contribution of the gut-liver axis to the immune signaling pathway of MASLD","volume":"13","author":"Liu","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.autrev.2026.104208_bb0700","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.3748\/wjg.v26.i17.1993","article-title":"Metabolic inflammation as an instigator of fibrosis during non-alcoholic fatty liver disease","volume":"26","author":"Katsarou","year":"2020","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.autrev.2026.104208_bb0705","doi-asserted-by":"crossref","first-page":"G270","DOI":"10.1152\/ajpgi.00304.2014","article-title":"Hepatic TLR4 signaling in obese MASLD","volume":"309","author":"Sharifnia","year":"2015","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.autrev.2026.104208_bb0710","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1002\/hep.31056","article-title":"Increased liver localization of lipopolysaccharides in human and experimental MASLD","volume":"72","author":"Carpino","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.autrev.2026.104208_bb0715","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.770986","article-title":"Endotoxins and non-alcoholic fatty liver disease","volume":"12","author":"Kessoku","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.autrev.2026.104208_bb0720","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1161\/ATVBAHA.117.309017","article-title":"STING-IRF3 triggers endothelial inflammation in response to free fatty acid-induced mitochondrial damage in diet-induced obesity","volume":"37","author":"Mao","year":"2017","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.autrev.2026.104208_bb0725","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1002\/hep.29742","article-title":"Lipotoxicity induces hepatic protein inclusions through TANK binding kinase 1-mediated p62\/sequestosome 1 phosphorylation","volume":"68","author":"Cho","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.autrev.2026.104208_bb0730","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2018.09.010","article-title":"Expression of STING is increased in liver tissues from patients with MASLD and promotes macrophage-mediated hepatic inflammation and fibrosis in mice","volume":"155","author":"Luo","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.autrev.2026.104208_bb0735","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/s41374-019-0342-6","article-title":"STING expression in monocyte-derived macrophages is associated with the progression of liver inflammation and fibrosis in patients with nonalcoholic fatty liver disease","volume":"100","author":"Wang","year":"2020","journal-title":"Lab Investig"},{"key":"10.1016\/j.autrev.2026.104208_bb0740","doi-asserted-by":"crossref","first-page":"6965","DOI":"10.3748\/wjg.v22.i31.6965","article-title":"Mitochondrial DNA from hepatocytes as a ligand for TLR9: Drivers of nonalcoholic steatohepatitis?","volume":"22","author":"Handa","year":"2016","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.autrev.2026.104208_bb0745","doi-asserted-by":"crossref","first-page":"240","DOI":"10.3350\/cmh.2020.0048","article-title":"Limited expression of toll-like receptor 9 on T cells and its functional consequences in patients with nonalcoholic fatty liver disease","volume":"26","author":"Yu","year":"2020","journal-title":"Clin Mol Hepatol"},{"key":"10.1016\/j.autrev.2026.104208_bb0750","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1002\/hep.29523","article-title":"NLRP3 inflammasome driven liver injury and fibrosis: roles of IL-17 and TNF in mice","volume":"67","author":"Wree","year":"2018","journal-title":"Hepatology"},{"issue":"7575","key":"10.1016\/j.autrev.2026.104208_bb0755","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.autrev.2026.104208_bb0760","first-page":"21","article-title":"Ghrelin reduces TNF-\u03b1-induced human hepatocyte apoptosis, autophagy, and pyroptosis: role in obesity-associated NAFLD","volume":"104","author":"Ezquerro","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"10.1016\/j.autrev.2026.104208_bb0765","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1016\/j.clnu.2024.08.007","article-title":"FNDC4 reduces hepatocyte inflammatory cell death via AMPK\u03b1 in metabolic dysfunction-associated steatotic liver disease","volume":"43","author":"Neira","year":"2024","journal-title":"Clin Nutr"},{"key":"10.1016\/j.autrev.2026.104208_bb0770","article-title":"The role and mechanism of pyroptosis and potential therapeutic targets in non-alcoholic fatty liver disease (MASLD)","volume":"12","author":"Li","year":"2024","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.autrev.2026.104208_bb0775","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.tcb.2017.05.005","article-title":"Gasdermins: effectors of pyroptosis","volume":"27","author":"Kovacs","year":"2017","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.autrev.2026.104208_bb0780","doi-asserted-by":"crossref","DOI":"10.3390\/cells9102148","article-title":"The absence of NLRP3-inflammasome modulates hepatic fibrosis progression, lipid metabolism, and inflammation in KO NLRP3 mice during aging","volume":"9","author":"Gallego","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.autrev.2026.104208_bb0785","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/s41590-021-00886-5","article-title":"NLRP3 inflammasome in cancer and metabolic diseases","volume":"22","author":"Sharma","year":"2021","journal-title":"Nat Immunol"},{"key":"10.1016\/j.autrev.2026.104208_bb0790","doi-asserted-by":"crossref","first-page":"731","DOI":"10.2147\/DDDT.S231916","article-title":"Ox-LDL causes endothelial cell injury through ASK1\/NLRP3-mediated inflammasome activation via endoplasmic reticulum stress","volume":"14","author":"Hang","year":"2020","journal-title":"Drug Des Devel Ther"},{"key":"10.1016\/j.autrev.2026.104208_bb0795","article-title":"NLRP3 inflammasome: checkpoint connecting innate and adaptive immunity in autoimmune diseases","volume":"12","author":"Zhang","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.autrev.2026.104208_bb0800","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2015.248","article-title":"ER stress induces NLRP3 inflammasome activation and hepatocyte death","volume":"6","author":"Lebeaupin","year":"2015","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.autrev.2026.104208_bb0805","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11030948","article-title":"Preservation of mitochondrial health in liver ischemia\/reperfusion injury","volume":"11","author":"Machado","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.autrev.2026.104208_bb0810","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.565616","article-title":"Organ restoration with normothermic machine perfusion and immune reaction","volume":"11","author":"Parente","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.autrev.2026.104208_bb0815","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1007\/BF02093792","article-title":"Modulation of ischemia-reperfusion-induced hepatic injury by KCs","volume":"39","author":"Shiratori","year":"1994","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.autrev.2026.104208_bb0820","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1097\/00007890-199411270-00003","article-title":"Pathogenic role of Kupffer cell activation in the reperfusion injury of cold-preserved liver","volume":"58","author":"Arii","year":"1994","journal-title":"Transplantation"},{"key":"10.1016\/j.autrev.2026.104208_bb0825","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.jhep.2012.05.012","article-title":"Nilotinib protects the murine liver from ischemia\/reperfusion injury","volume":"57","author":"Ocuin","year":"2012","journal-title":"J Hepatol"},{"key":"10.1016\/j.autrev.2026.104208_bb0830","article-title":"Growth hormone secretagogues protect mouse cardiomyocytes from in vitro ischemia\/reperfusion injury through regulation of intracellular calcium","volume":"7","author":"Ma","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.autrev.2026.104208_bb0835","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s11033-012-1939-7","article-title":"Mutations in the D-loop region and increased copy number of mitochondrial DNA in human laryngeal squamous cell carcinoma","volume":"40","author":"Guo","year":"2013","journal-title":"Mol Biol Rep"},{"key":"10.1016\/j.autrev.2026.104208_bb0840","article-title":"Myeloid but not hepatocytic CD38 is a key driver for hepatic ischemia\/reperfusion injury","volume":"10","author":"Zhao","year":"2025","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.autrev.2026.104208_bb0845","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s13578-025-01376-z","article-title":"Clusterin deficiency exacerbates cholestatic liver disease through ER stress and NLRP3 inflammasome activation","volume":"15","author":"Seo","year":"2025","journal-title":"Cell Biosci"},{"key":"10.1016\/j.autrev.2026.104208_bb0850","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1177\/145749691110000104","article-title":"Long-term results of liver transplantation","volume":"100","author":"\u00c5berg","year":"2011","journal-title":"Scand J Surg"},{"key":"10.1016\/j.autrev.2026.104208_bb0855","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.transproceed.2011.11.001","article-title":"The role of CD14 and Toll-like receptor 4 of KCs in hepatic ischemia-reperfusion injury in rats","volume":"44","author":"Luan","year":"2012","journal-title":"Transplant Proc"},{"key":"10.1016\/j.autrev.2026.104208_bb0860","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jhep.2015.02.009","article-title":"Hypoxia induced HMGB1 and mitochondrial DNA interactions mediate tumor growth in hepatocellular carcinoma through Toll-like receptor 9","volume":"63","author":"Liu","year":"2015","journal-title":"J Hepatol"},{"key":"10.1016\/j.autrev.2026.104208_bb0865","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21217889","article-title":"The molecular mechanisms of iron metabolism and its role in cardiac dysfunction and cardioprotection","volume":"21","author":"Ravingerov\u00e1","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.autrev.2026.104208_bb0870","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/j.ajpath.2022.09.002","article-title":"Expression of STING is increased in monocyte-derived macrophages and contributes to liver inflammation in hepatic ischemia-reperfusion injury","volume":"192","author":"Jiao","year":"2022","journal-title":"Am J Pathol"},{"key":"10.1016\/j.autrev.2026.104208_bb0875","doi-asserted-by":"crossref","first-page":"356","DOI":"10.4049\/jimmunol.1502301","article-title":"Characterization of the inflammasome in human KCs in response to synthetic agonists and pathogens","volume":"197","author":"Zannetti","year":"2016","journal-title":"J Immunol"},{"key":"10.1016\/j.autrev.2026.104208_bb0880","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/hep.26320","article-title":"ASC\/caspase-1\/IL-1\u03b2 signaling triggers inflammatory responses by promoting HMGB1 induction in liver ischemia\/reperfusion injury","volume":"58","author":"Kamo","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.autrev.2026.104208_bb0885","article-title":"The role of NLRP3 inflammasome activation pathway of hepatic macrophages in liver ischemia-reperfusion injury","volume":"13","author":"Wu","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.autrev.2026.104208_bb0890","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.jhep.2021.09.007","article-title":"MASLD-driven HCC: Safety and efficacy of current and emerging treatment options","volume":"76","author":"Foerster","year":"2022","journal-title":"J Hepatol"},{"key":"10.1016\/j.autrev.2026.104208_bb0895","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2016.18","article-title":"Hepatocellular carcinoma","volume":"2","author":"Llovet","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.autrev.2026.104208_bb0900","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1093\/ije\/dyi206","article-title":"A mathematical model to estimate global hepatitis B disease burden and vaccination impact","volume":"34","author":"Goldstein","year":"2005","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.autrev.2026.104208_bb0905","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1158\/1940-6207.CAPR-13-0168","article-title":"Reduced aflatoxin exposure presages decline in liver cancer mortality in an endemic region of China","volume":"6","author":"Chen","year":"2013","journal-title":"Cancer Prev Res (Phila)"},{"key":"10.1016\/j.autrev.2026.104208_bb0910","doi-asserted-by":"crossref","first-page":"7413","DOI":"10.3748\/wjg.v12.i46.7413","article-title":"Role of KCs in the pathogenesis of liver disease","volume":"12","author":"Kolios","year":"2006","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.autrev.2026.104208_bb0915","doi-asserted-by":"crossref","first-page":"8067","DOI":"10.1158\/0008-5472.CAN-09-0901","article-title":"Kupffer cell suppression of CD8+ T cells in human hepatocellular carcinoma is mediated by B7-H1\/programmed death-1 interactions","volume":"69","author":"Wu","year":"2009","journal-title":"Cancer Res"},{"key":"10.1016\/j.autrev.2026.104208_bb0920","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.3748\/wjg.v9.i9.1946","article-title":"Pathomorphological study on location and distribution of KCs in hepatocellular carcinoma","volume":"9","author":"Liu","year":"2003","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.autrev.2026.104208_bb0925","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.molcel.2016.02.011","article-title":"Mitochondria and Cancer","volume":"61","author":"Zong","year":"2016","journal-title":"Mol Cell"},{"key":"10.1016\/j.autrev.2026.104208_bb0930","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1097\/00003677-200307000-00009","article-title":"Oxidative damage to DNA and aging","volume":"31","author":"Van Remmen","year":"2003","journal-title":"Exerc Sport Sci Rev"},{"key":"10.1016\/j.autrev.2026.104208_bb0935","article-title":"Hypoxia regulates the mitochondrial activity of hepatocellular carcinoma cells through HIF\/HEY1\/PINK1 pathway","volume":"10","author":"Chiu","year":"2019","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.autrev.2026.104208_bb0940","first-page":"193","article-title":"A self-accelerating 'copper bomb' strategy activated innate and adaptive immune response against triple-negative breast cancer","volume":"49","author":"Xu","year":"2025","journal-title":"Bioact Mater"},{"key":"10.1016\/j.autrev.2026.104208_bb0945","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1158\/1535-7163.MCT-23-0540","article-title":"A compound that inhibits glycolysis in prostate cancer controls growth of advanced prostate cancer","volume":"23","author":"Uo","year":"2024","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.autrev.2026.104208_bb0950","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1126\/science.1160809","article-title":"Understanding the Warburg effect: the metabolic requirements of cell proliferation","volume":"324","author":"Vander Heiden","year":"2009","journal-title":"Science"},{"issue":"25","key":"10.1016\/j.autrev.2026.104208_bb0955","doi-asserted-by":"crossref","first-page":"5007","DOI":"10.1038\/s41388-019-0772-z","article-title":"Mitochondrial fission-induced mtDNA stress promotes tumor-associated macrophage infiltration and HCC progression","volume":"38","author":"Bao","year":"2019","journal-title":"Oncogene"},{"key":"10.1016\/j.autrev.2026.104208_bb0960","doi-asserted-by":"crossref","first-page":"G794","DOI":"10.1152\/ajpgi.00390.2014","article-title":"Activation of the GP130-STAT3 axis and its potential implications in nonalcoholic fatty liver disease","volume":"308","author":"Min","year":"2015","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.autrev.2026.104208_bb0965","doi-asserted-by":"crossref","first-page":"vii9","DOI":"10.1093\/neuonc\/nov151","article-title":"Immunosuppressive mechanisms in glioblastoma","volume":"17","author":"Nduom","year":"2015","journal-title":"Neuro-Oncology"},{"key":"10.1016\/j.autrev.2026.104208_bb0970","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0198464","article-title":"Impact of MMP-2 and MMP-9 enzyme activity on wound healing, tumor growth and RACPP cleavage","volume":"13","author":"Hingorani","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.autrev.2026.104208_bb0975","doi-asserted-by":"crossref","DOI":"10.1186\/s12943-020-01247-w","article-title":"cGAS-STING pathway in cancer biotherapy","volume":"19","author":"Wang","year":"2020","journal-title":"Mol Cancer"},{"key":"10.1016\/j.autrev.2026.104208_bb0980","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1038\/s41388-019-1108-8","article-title":"The cGAS-STING pathway is a therapeutic target in a preclinical model of hepatocellular carcinoma","volume":"39","author":"Thomsen","year":"2020","journal-title":"Oncogene"},{"key":"10.1016\/j.autrev.2026.104208_bb0985","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nrc3239","article-title":"The blockade of immune checkpoints in cancer immunotherapy","volume":"12","author":"Pardoll","year":"2012","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.autrev.2026.104208_bb0990","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.jhep.2017.02.026","article-title":"Targeting hepatic macrophages to treat liver diseases","volume":"66","author":"Tacke","year":"2017","journal-title":"J Hepatol"},{"key":"10.1016\/j.autrev.2026.104208_bb0995","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1431211","article-title":"Regulatory T cells and immune escape in HCC: understanding the tumor microenvironment and advancing CAR-T cell therapy","volume":"15","author":"Du","year":"2024","journal-title":"Front Immunol"},{"key":"10.1016\/j.autrev.2026.104208_bb1000","doi-asserted-by":"crossref","first-page":"154","DOI":"10.3892\/or.2025.8987","article-title":"Senescence-associated IL-33 secretion undermines sorafenib efficacy in hepatocellular carcinoma via immune evasion","volume":"54","author":"Lin","year":"2025","journal-title":"Oncol Rep"},{"key":"10.1016\/j.autrev.2026.104208_bb1005","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/s41419-025-07473-8","article-title":"Circulating mitochondrial DNA promotes M2 polarization of tumor associated macrophages and HCC resistance to sorafenib","volume":"16","author":"Yang","year":"2025","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.autrev.2026.104208_bb1010","article-title":"Mitochondrial dysfunction: a promising therapeutic target for liver diseases","volume":"11","author":"Chen","year":"2023","journal-title":"Genes Dis"},{"issue":"1","key":"10.1016\/j.autrev.2026.104208_bb1015","doi-asserted-by":"crossref","first-page":"196","DOI":"10.3350\/cmh.2024.0527","article-title":"Aberrant fragmentomic features of circulating cell-free mitochondrial DNA enable early detection and prognosis prediction of hepatocellular carcinoma","volume":"31","author":"Liu","year":"2025","journal-title":"Clin Mol Hepatol"}],"container-title":["Autoimmunity Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568997226002223?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1568997226002223?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T19:27:29Z","timestamp":1793734049000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1568997226002223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":203,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2027,1]]}},"alternative-id":["S1568997226002223"],"URL":"https:\/\/doi.org\/10.1016\/j.autrev.2026.104208","relation":{},"ISSN":["1568-9972"],"issn-type":[{"value":"1568-9972","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitochondrial DNA mediated Kupffer cell activation in the pathogenesis and progression of liver diseases","name":"articletitle","label":"Article Title"},{"value":"Autoimmunity Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.autrev.2026.104208","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104208"}}