{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:15:30Z","timestamp":1793121330675,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01NSL05132-01A1"],"award-info":[{"award-number":["1R01NSL05132-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000090","name":"Congressionally Directed Medical Research Programs","doi-asserted-by":"publisher","award":["W81XWH-17-1-0641"],"award-info":[{"award-number":["W81XWH-17-1-0641"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["annalsofvascularsurgery.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Vascular Surgery"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.avsg.2021.08.014","type":"journal-article","created":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T20:47:46Z","timestamp":1634330866000},"page":"421-426","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"special_numbering":"C","title":["\u201cDecreasing Postamputation Pain with the Regenerative Peripheral Nerve Interface (RPNI)\u201d"],"prefix":"10.1016","volume":"79","author":[{"given":"Carrie A.","family":"Kubiak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6986-8631","authenticated-orcid":false,"given":"Widya","family":"Adidharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore A.","family":"Kung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen W.P.","family":"Kemp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S.","family":"Cederna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandu","family":"Vemuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.avsg.2021.08.014_bib0001","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.apmr.2007.11.005","article-title":"Estimating the prevalence of limb loss in the United States: 2005 to 2050","volume":"89","author":"Ziegler-Graham","year":"2008","journal-title":"Arch PhysMed Rehabil"},{"key":"10.1016\/j.avsg.2021.08.014_bib0002","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1097\/PHM.0b013e3181b306ec","article-title":"Chronic pain associated with upper-limb loss","volume":"88","author":"Hanley","year":"2016","journal-title":"Am JPhys Med Rehabil"},{"key":"10.1016\/j.avsg.2021.08.014_bib0003","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1177\/0309364610397087","article-title":"Factors affecting quality of life in lower limb amputees","volume":"35","author":"Sinha","year":"2011","journal-title":"Prosthet Orthot Int"},{"key":"10.1016\/j.avsg.2021.08.014_bib0004","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0304-3959(00)00264-5","article-title":"Phantom pain and phantom sensations in upper limb amputees: an epidemiological study","volume":"87","author":"Kooijman","year":"2000","journal-title":"Pain"},{"key":"10.1016\/j.avsg.2021.08.014_bib0005","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1177\/0309364615596067","article-title":"Long-term mortality after lower-limb amputation","volume":"40","author":"Singh","year":"2016","journal-title":"Prosthet Orthot Int"},{"key":"10.1016\/j.avsg.2021.08.014_bib0006","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.apmr.2016.09.118","article-title":"Cross-sectional assessment of factors related to pain intensity and pain interference in lower limb prosthesis users","volume":"98","author":"Morgan","year":"2017","journal-title":"Arch Phys Med Rehabil"},{"key":"10.1016\/j.avsg.2021.08.014_bib0007","doi-asserted-by":"crossref","first-page":"e1038","DOI":"10.1097\/GOX.0000000000001038","article-title":"Regenerative peripheral nerve interfaces for the treatment of postamputation neuroma pain: a pilot study","volume":"4","author":"Woo","year":"2016","journal-title":"Plast Reconstr Surg - Global Open"},{"key":"10.1016\/j.avsg.2021.08.014_bib0008","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1097\/01.prs.0000233048.15879.0e","article-title":"Surgical treatment of chronic phantom limb sensation and limb pain after lower limb amputation","volume":"118","author":"Prantl","year":"2006","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.avsg.2021.08.014_bib0009","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1227\/NEU.0000000000001313","article-title":"Prevention of painful neuroma and phantom limb pain after transfemoral amputations through concomitant nerve coaptation and collagen nerve wrapping","volume":"79","author":"Economides","year":"2016","journal-title":"Neurosurg"},{"key":"10.1016\/j.avsg.2021.08.014_bib0010","doi-asserted-by":"crossref","first-page":"e321","DOI":"10.1097\/BOT.0000000000000337","article-title":"Traction neurectomy for treatment of painful residual limb neuroma in lower extremity amputees","volume":"29","author":"Pet","year":"2015","journal-title":"J Orthop Trauma"},{"key":"10.1016\/j.avsg.2021.08.014_bib0011","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1097\/00006534-198603000-00016","article-title":"Treatment of the painful neuroma by neuroma resection and muscle implantation","volume":"77","author":"Dellon","year":"1986","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.avsg.2021.08.014_bib0012","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1097\/SAP.0b013e3182583cf9","article-title":"Outcomes of the surgical treatment of peripheral neuromas of the hand and forearm a 25-year comparative outcome study","volume":"71","author":"Guse","year":"2013","journal-title":"Ann Plast Surg"},{"key":"10.1016\/j.avsg.2021.08.014_bib0013","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1097\/SLA.0000000000003088","article-title":"Targeted muscle reinnervation treats neuroma and phantom pain in major limb amputees: a randomized clinical trial","volume":"270","author":"Dumanian","year":"2019","journal-title":"Ann Surg"},{"key":"10.1016\/j.avsg.2021.08.014_bib0014","doi-asserted-by":"crossref","first-page":"e1952","DOI":"10.1097\/GOX.0000000000001952","article-title":"Surgical algorithm for neuroma management: a changing treatment paradigm","volume":"6","author":"Eberlin","year":"2018","journal-title":"Plast Reconstr Surg - Global Open"},{"key":"10.1016\/j.avsg.2021.08.014_bib0015","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1097\/01.prs.0000242487.62487.fb","article-title":"Improved myoelectric prosthesis control accomplished using multiple nerve transfers","volume":"118","author":"Hijjawi","year":"2006","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.avsg.2021.08.014_bib0016","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1001\/jamasurg.2018.0864","article-title":"Regenerative peripheral nerve interface for management of postamputation neuroma","volume":"153","author":"Kubiak","year":"2018","journal-title":"JAMA Surg"},{"key":"10.1016\/j.avsg.2021.08.014_bib0017","doi-asserted-by":"crossref","DOI":"10.1097\/PRS.0000000000005922","article-title":"Prophylactic regenerative peripheral nerve interfaces to prevent postamputation pain","volume":"144","author":"Kubiak","year":"2019","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.avsg.2021.08.014_bib0018","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1097\/PRS.0000000000000168","article-title":"Regenerative peripheral nerve interface viability and signal transduction with an implanted electrode","volume":"133","author":"Kung","year":"2014","journal-title":"Plast ReconstrSurg"},{"key":"10.1016\/j.avsg.2021.08.014_bib0019","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1126\/scitranslmed.aay2857","article-title":"A regenerative peripheral nerve interface allows real-time control of an artificial hand in upper limb amputees","volume":"12","author":"Vu","year":"2020","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.avsg.2021.08.014_bib0020","article-title":"Surgically implanted electrodes enable real-time finger and grasp pattern recognition for prosthetic hands","author":"Vaskov","year":"2020","journal-title":"Med Rxiv"},{"key":"10.1016\/j.avsg.2021.08.014_bib0021","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/mus.27138","article-title":"Regenerative peripheral nerve interface free muscle graft mass and function","volume":"63","author":"Hu","year":"2021","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.avsg.2021.08.014_bib0022","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1227\/00006123-198102000-00007","article-title":"Clinical and ultrastructural study of painful neuroma","volume":"8","author":"Cravioto","year":"1981","journal-title":"Neurosurg"},{"key":"10.1016\/j.avsg.2021.08.014_bib0023","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1093\/neuros\/nyx500","article-title":"Current state of the surgical treatment of terminal neuromas","volume":"83","author":"Ives","year":"2018","journal-title":"Neurosurg"},{"key":"10.1016\/j.avsg.2021.08.014_bib0024","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/00130911-199709000-00007","article-title":"Evaluation and treatment of the painful neuroma","volume":"1","author":"Mackinnon","year":"1997","journal-title":"Tech Hand Up Extrem Surg"},{"key":"10.1016\/j.avsg.2021.08.014_bib0025","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.cps.2020.01.004","article-title":"Regenerative peripheral nerve interfaces for prevention and management of neuromas","volume":"47","author":"Santosa","year":"2020","journal-title":"Clin Plast Surg"},{"key":"10.1016\/j.avsg.2021.08.014_bib0026","article-title":"Restoration of proprioceptive and cutaneous sensation using regenerative peripheral nerve interfaces (RPNIs) in humans with upper-limb amputations","author":"Vu","year":"2020","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.avsg.2021.08.014_bib0027","first-page":"e60841","article-title":"Fabrication of the composite regenerative peripheral nerve interface (C-RPNI) in the adult rat","author":"Svientek","year":"2020","journal-title":"J Vis Exp"},{"key":"10.1016\/j.avsg.2021.08.014_bib0028","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/s12984-018-0452-1","article-title":"Regenerative peripheral nerve interfaces for real-time, proportional control of a Neuroprosthetic hand","volume":"15","author":"Frost","year":"2018","journal-title":"J NeuroEng Rehabilitation"},{"key":"10.1016\/j.avsg.2021.08.014_bib0029","doi-asserted-by":"crossref","first-page":"e2792","DOI":"10.1097\/GOX.0000000000002792","article-title":"Regenerative peripheral nerve interfaces for the management of symptomatic hand and digital neuromas","volume":"8","author":"Hooper","year":"2020","journal-title":"Plast ReconstrSurg - Global Open"},{"key":"10.1016\/j.avsg.2021.08.014_bib0030","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1109\/TNSRE.2017.2772961","article-title":"Closed-loop continuous hand control via chronic recording of regenerative peripheral nerve interfaces","volume":"26","author":"Vu","year":"2018","journal-title":"IEEE Trans Neural Syst Rehabilitation Eng"},{"key":"10.1016\/j.avsg.2021.08.014_bib0031","article-title":"Chronic recording of hand prosthesis control signals via a regenerative peripheral nerve interface in a rhesus macaque","volume":"13","author":"Irwin","year":"2016","journal-title":"JNeural Eng"}],"container-title":["Annals of Vascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890509621007111?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890509621007111?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:06:57Z","timestamp":1760188017000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890509621007111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":31,"alternative-id":["S0890509621007111"],"URL":"https:\/\/doi.org\/10.1016\/j.avsg.2021.08.014","relation":{},"ISSN":["0890-5096"],"issn-type":[{"value":"0890-5096","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"\u201cDecreasing Postamputation Pain with the Regenerative Peripheral Nerve Interface (RPNI)\u201d","name":"articletitle","label":"Article Title"},{"value":"Annals of Vascular Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.avsg.2021.08.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}