{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:42:34Z","timestamp":1786984954446,"version":"build-2736575974"},"reference-count":10,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"vor","delay-in-days":110,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain and Spine"],"published-print":{"date-parts":[[2025]]},"DOI":"10.1016\/j.bas.2025.104256","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T19:21:58Z","timestamp":1745263318000},"page":"104256","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["DNA methylation-based profiling is an effective asset for identification of tumors in suspected, yet immunohistochemically, unspecified neuro-oncological cases"],"prefix":"10.1016","volume":"5","author":[{"given":"Christian","family":"Uhl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naseem","family":"Ayoub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Faust","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Vajkoczy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonille","family":"Schweizer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josefine","family":"Radke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6177-1755","authenticated-orcid":false,"given":"Felix","family":"Ehret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Capper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2859-4395","authenticated-orcid":false,"given":"Julia Sophie","family":"Onken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bas.2025.104256_bib1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1158\/1078-0432.CCR-17-1184","article-title":"Fluorescein-Guided surgery for resection of high-grade gliomas: a multicentric prospective phase II study (FLUOGLIO)","volume":"24","author":"Acerbi","year":"2018","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bas.2025.104256_bib3","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.wneu.2017.04.104","article-title":"Accuracy of VarioGuide frameless stereotactic system against frame-based stereotaxy: prospective, randomized, single-center study","volume":"104","author":"Bradac","year":"2017","journal-title":"World Neurosurg"},{"issue":"7697","key":"10.1016\/j.bas.2025.104256_bib4","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nature26000","article-title":"DNA methylation-based classification of central nervous system tumours","volume":"555","author":"Capper","year":"2018","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.bas.2025.104256_bib5","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s00401-018-1879-y","article-title":"Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience","volume":"136","author":"Capper","year":"2018","journal-title":"Acta Neuropathol."},{"issue":"1","key":"10.1016\/j.bas.2025.104256_bib7","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s40478-019-0668-8","article-title":"Methylation array profiling of adult brain tumours: diagnostic outcomes in a large, single centre","volume":"7","author":"Jaunmuktane","year":"2019","journal-title":"Acta Neuropathol. Commun."},{"issue":"8","key":"10.1016\/j.bas.2025.104256_bib9","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1093\/neuonc\/noab106","article-title":"The 2021 WHO classification of tumors of the central nervous system: a summary","volume":"23","author":"Louis","year":"2021","journal-title":"Neuro Oncol."},{"issue":"2","key":"10.1016\/j.bas.2025.104256_bib10","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s00381-014-2552-y","article-title":"(18)F-FET-PET guided surgical biopsy and resection in children and adolescence with brain tumors","volume":"31","author":"Misch","year":"2015","journal-title":"Childs Nerv. Syst."},{"issue":"23 Suppl. 5","key":"10.1016\/j.bas.2025.104256_bib11","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1093\/neuonc\/noab143","article-title":"DNA methylation profiling as a model for discovery and precision diagnostics in neuro-oncology","volume":"23","author":"Pratt","year":"2021","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.bas.2025.104256_bib14","first-page":"9","article-title":"Fluorescence-guided resections of malignant gliomas--an overview","volume":"88","author":"Stummer","year":"2003","journal-title":"Acta Neurochir. Suppl."},{"issue":"2","key":"10.1016\/j.bas.2025.104256_bib16","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1097\/PAI.0000000000000833","article-title":"Milestones in immunohistochemistry and molecular morphology","volume":"28","author":"Taylor","year":"2020","journal-title":"Appl. Immunohistochem. Mol. Morphol."}],"container-title":["Brain and Spine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S277252942500075X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S277252942500075X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T16:53:49Z","timestamp":1772470429000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S277252942500075X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":10,"alternative-id":["S277252942500075X"],"URL":"https:\/\/doi.org\/10.1016\/j.bas.2025.104256","relation":{},"ISSN":["2772-5294"],"issn-type":[{"value":"2772-5294","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DNA methylation-based profiling is an effective asset for identification of tumors in suspected, yet immunohistochemically, unspecified neuro-oncological cases","name":"articletitle","label":"Article Title"},{"value":"Brain and Spine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bas.2025.104256","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of EUROSPINE, the Spine Society of Europe, EANS, the European Association of Neurosurgical Societies.","name":"copyright","label":"Copyright"}],"article-number":"104256"}}