{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T10:36:26Z","timestamp":1793010986287,"version":"4.5.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"vor","delay-in-days":53,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain and Spine"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/j.bas.2026.105989","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:19:28Z","timestamp":1771892368000},"page":"105989","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Tranexamic acid in spinal surgery: a stratified protocol from the surgeon's point of view"],"prefix":"10.1016","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3043-3704","authenticated-orcid":false,"given":"D.","family":"Rodr\u00edguez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Melero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Pont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7773-4583","authenticated-orcid":false,"given":"V.","family":"Calvet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Campana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.C.","family":"Raya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Vila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Bartolom\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Del Arco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Vil\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Isart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Manzano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Lafuente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bas.2026.105989_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.recot.2019.09.007","article-title":"Tranexamic acid in orthopaedic surgery: a paradigm shift in transfusion","volume":"64","author":"Basora","year":"2020","journal-title":"Rev. Espa\u00f1ola Cirug\u00eda Ortop\u00e9dica Traumatol."},{"issue":"22","key":"10.1016\/j.bas.2026.105989_bib2","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1097\/BRS.0000000000001047","article-title":"Risk factors for blood transfusion with primary posterior lumbar fusion","volume":"40","author":"Basques","year":"2015","journal-title":"Spine"},{"key":"10.1016\/j.bas.2026.105989_bib3","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1161\/CIRCOUTCOMES.113.000359","article-title":"Propensity score methods for confounding control in nonexperimental research","volume":"6","author":"Brookhart","year":"2013","journal-title":"Circ. Cardiovasc. Qual. Outcomes"},{"issue":"5","key":"10.1016\/j.bas.2026.105989_bib4","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s00586-010-1500-0","article-title":"Risk analysis of blood transfusion requirements in emergency and elective spinal surgery","volume":"20","author":"Butler","year":"2011","journal-title":"Eur. Spine J."},{"key":"10.1016\/j.bas.2026.105989_bib5","series-title":"StatPearls. Treasure Island (FL)","article-title":"Tranexamic acid","author":"Chauncey","year":"2025"},{"issue":"1","key":"10.1016\/j.bas.2026.105989_bib6","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1186\/s12891-020-03233-1","article-title":"Effectiveness and safety of surgical interventions for treating adolescent idiopathic scoliosis: a Bayesian meta-analysis","volume":"21","author":"Chen","year":"2020","journal-title":"BMC Muscoskelet. Disord."},{"issue":"1","key":"10.1016\/j.bas.2026.105989_bib8","doi-asserted-by":"crossref","first-page":"E65","DOI":"10.1097\/BRS.0000000000003737","article-title":"Impact of preoperative platelet count on bleeding risk and allogeneic transfusion in multilevel spine surgery","volume":"46","author":"Chow","year":"2021","journal-title":"Spine"},{"issue":"3","key":"10.1016\/j.bas.2026.105989_bib9","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1093\/bja\/aew434","article-title":"Intraoperative tranexamic acid use in major spine surgery in adults: a multicentre, randomized, placebo-controlled trial","volume":"118","author":"Colomina","year":"2017","journal-title":"Br. J. Anaesth."},{"issue":"5","key":"10.1016\/j.bas.2026.105989_bib10","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1111\/trf.16864","article-title":"Allogeneic blood transfusions and infection risk in lumbar spine surgery: an American college of surgeons national surgery quality improvement program study","volume":"62","author":"Falsetto","year":"2022","journal-title":"Transfusion"},{"key":"10.1016\/j.bas.2026.105989_bib11","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.recot.2023.04.002","article-title":"El papel de la cirug\u00eda m\u00ednimamente invasiva de columna en el tratamiento de las met\u00e1stasis vertebrales: una revisi\u00f3n narrativa","volume":"67","author":"Garr\u00edguez-P\u00e9rez","year":"2023","journal-title":"Rev. Espa\u00f1ola Cirug\u00eda Ortop\u00e9dica Traumatol."},{"issue":"1","key":"10.1016\/j.bas.2026.105989_bib12","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1308\/1478708051414","article-title":"How to approach major surgery where patients refuse blood transfusion (including Jehovah's witnesses)","volume":"87","author":"Gohel","year":"2005","journal-title":"Ann. R. Coll. Surg. Engl."},{"key":"10.1016\/j.bas.2026.105989_bib13","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.wneu.2018.09.115","article-title":"The efficacy and safety of intravenous tranexamic acid in reducing surgical blood loss in posterior lumbar interbody fusion for the adult: a systematic review and a meta-analysis","volume":"122","author":"Gong","year":"2019","journal-title":"World Neurosurg."},{"issue":"23","key":"10.1016\/j.bas.2026.105989_bib14","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.2106\/JBJS.18.00314","article-title":"Tranexamic acid is efficacious at decreasing the rate of blood loss in adolescent scoliosis surgery: a randomized placebo-controlled trial","volume":"100","author":"Goobie","year":"2018","journal-title":"J. Bone Joint Surg. Am."},{"issue":"5","key":"10.1016\/j.bas.2026.105989_bib15","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.spinee.2015.02.010","article-title":"Allogeneic blood transfusions and postoperative infections after lumbar spine surgery","volume":"15","author":"Janssen","year":"2015","journal-title":"Spine J."},{"issue":"1","key":"10.1016\/j.bas.2026.105989_bib16","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.spinee.2015.10.014","article-title":"Risk of infectious complications associated with blood transfusion in elective spinal surgery: a propensity score matched analysis","volume":"16","author":"Kato","year":"2016","journal-title":"Spine J."},{"issue":"16","key":"10.1016\/j.bas.2026.105989_bib17","first-page":"E949","article-title":"Hemostats in spine surgery: literature review and expert panel recommendations","volume":"43","author":"Le Huec","year":"2018","journal-title":"Spine"},{"key":"10.1016\/j.bas.2026.105989_bib18","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1186\/s12891-022-05361-2","article-title":"The efficacy and safety of intravenous tranexamic acid in patients with posterior operation of multilevel thoracic spine stenosis: a prospective randomized controlled trial","volume":"23","author":"Lei","year":"2022","journal-title":"BMC Muscoskelet. Disord."},{"key":"10.1016\/j.bas.2026.105989_bib19","series-title":"La Medicina En La Historia\/Medicine in History. Madrid: La Esfera De Los Libros","first-page":"133","author":"L\u00f3pez Pi\u00f1ero","year":"2002"},{"issue":"16","key":"10.1016\/j.bas.2026.105989_bib20","doi-asserted-by":"crossref","first-page":"E949","DOI":"10.1097\/BRS.0000000000002580","article-title":"The perioperative efficacy and safety of antifibrinolytics in adult spinal fusion surgery: a systematic review and meta-analysis","volume":"43","author":"Lu","year":"2018","journal-title":"Spine"},{"issue":"4","key":"10.1016\/j.bas.2026.105989_bib21","doi-asserted-by":"crossref","first-page":"T322","DOI":"10.1016\/j.recot.2024.03.006","article-title":"Hidden blood loss in minimally invasive surgery for osteoporotic vertebral fractures","volume":"68","author":"Mart\u00edn-Gorgojo","year":"2024","journal-title":"Rev. Espa\u00f1ola Cirug\u00eda Ortop\u00e9dica Traumatol."},{"issue":"4","key":"10.1016\/j.bas.2026.105989_bib22","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1093\/bja\/aex008","article-title":"Association of intraoperative cerebral and muscular tissue oxygen saturation with postoperative complications and length of hospital stay after major spine surgery: an observational study","volume":"118","author":"Meng","year":"2017","journal-title":"Br. J. Anaesth."},{"issue":"1 Suppl. l","key":"10.1016\/j.bas.2026.105989_bib23","doi-asserted-by":"crossref","first-page":"71S","DOI":"10.1177\/2192568219868475","article-title":"Minimizing blood loss in spine surgery","volume":"10","author":"Mikhail","year":"2020","journal-title":"Glob. Spine J."},{"issue":"18","key":"10.1016\/j.bas.2026.105989_bib24","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1097\/BRS.0000000000003176","article-title":"Postoperative blood salvage and autotransfusion for adult spinal deformity: a randomized controlled trial","volume":"45","author":"Nemani","year":"2020","journal-title":"Spine"},{"key":"10.1016\/j.bas.2026.105989_bib25","series-title":"Complex Spinal Surgery Services (All Ages): Service Specification. Version 2","year":"2021"},{"issue":"15","key":"10.1016\/j.bas.2026.105989_bib26","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1056\/NEJMe1600955","article-title":"Fusion for lumbar spinal stenosis\u2014safeguard or superfluous surgical implant?","volume":"374","author":"Peul","year":"2016","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.bas.2026.105989_bib27","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.spinee.2009.10.002","article-title":"Influence of perioperative resuscitation status on postoperative spine surgery complications","volume":"10","author":"Pull ter Gunne","year":"2010","journal-title":"Spine J."},{"issue":"3","key":"10.1016\/j.bas.2026.105989_bib28","doi-asserted-by":"crossref","first-page":"345","DOI":"10.3171\/2017.7.SPINE17301","article-title":"Percentage change in haemoglobin level and morbidity in spine surgery patients","volume":"28","author":"Purvis","year":"2018","journal-title":"J. Neurosurg. Spine"},{"issue":"10","key":"10.1016\/j.bas.2026.105989_bib29","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1007\/s00586-022-07315-7","article-title":"Tranexamic acid dosage for spinal surgery: a meta-analysis","volume":"31","author":"Qin","year":"2022","journal-title":"Eur. Spine J."},{"key":"10.1016\/j.bas.2026.105989_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.bas.2023.102682","article-title":"Management of incidental durotomies in an integrated orthopaedic and neurosurgical spinal unit","volume":"3","author":"Rodr\u00edguez","year":"2023","journal-title":"Brain Spine"},{"issue":"9734","key":"10.1016\/j.bas.2026.105989_bib31","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0140-6736(10)60835-5","article-title":"Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial","volume":"376","author":"Shakur","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.bas.2026.105989_bib32","article-title":"Removal of a giant musculocutaneous nerve schwannoma under intraoperative neurophysiological monitoring: case report video and review of the literature","author":"Susanibar","year":"2025","journal-title":"Neurocirug\u00eda (Engl Ed)"},{"key":"10.1016\/j.bas.2026.105989_bib33","first-page":"CD009733","article-title":"Antifibrinolytics (lysine analogues) for the prevention of bleeding in patients with haematological disorders","volume":"7","author":"Wardrop","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"issue":"5","key":"10.1016\/j.bas.2026.105989_bib34","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1213\/ANE.0000000000001485","article-title":"Spine surgery and blood loss: systematic review of clinical evidence","volume":"123","author":"Willner","year":"2016","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.bas.2026.105989_bib35","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1055\/s-0035-1563609","article-title":"Systemic and topical use of tranexamic acid in spinal surgery: a systematic review","volume":"6","author":"Winter","year":"2016","journal-title":"Glob. Spine J."},{"key":"10.1016\/j.bas.2026.105989_bib36","article-title":"The influence of antiplatelet drugs on outcomes of spinal surgery: a systematic review and meta-analysis","author":"Yu","year":"2024","journal-title":"Orthop. Traumatol. Surg. Res."}],"container-title":["Brain and Spine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772529426000652?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772529426000652?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T10:23:14Z","timestamp":1793010194000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772529426000652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":35,"alternative-id":["S2772529426000652"],"URL":"https:\/\/doi.org\/10.1016\/j.bas.2026.105989","relation":{},"ISSN":["2772-5294"],"issn-type":[{"value":"2772-5294","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tranexamic acid in spinal surgery: a stratified protocol from the surgeon's point of view","name":"articletitle","label":"Article Title"},{"value":"Brain and Spine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bas.2026.105989","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of EANS, the European Association of Neurosurgical Societies, EUROSPINE, the Spine Society of Europe.","name":"copyright","label":"Copyright"}],"article-number":"105989"}}