{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:08:29Z","timestamp":1791263309938,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,10,3]],"date-time":"2013-10-03T00:00:00Z","timestamp":1380758400000},"content-version":"vor","delay-in-days":397,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Bioenergetics"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1016\/j.bbabio.2012.05.011","type":"journal-article","created":{"date-parts":[[2012,5,31]],"date-time":"2012-05-31T05:00:18Z","timestamp":1338440418000},"page":"1628-1634","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":100,"title":["Inhibition of complex I regulates the mitochondrial permeability transition through a phosphate-sensitive inhibitory site masked by cyclophilin D"],"prefix":"10.1016","volume":"1817","author":[{"given":"Bo","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Chauvin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"De Paulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"De Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdallah","family":"Gharib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Vial","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Lablanche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Leverve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Bernardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Ovize","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Fontaine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbabio.2012.05.011_bb0005","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0304-4157(95)00003-A","article-title":"The mitochondrial permeability transition","volume":"1241","author":"Zoratti","year":"1995","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbabio.2012.05.011_bb0010","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/nature03434","article-title":"Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death","volume":"434","author":"Baines","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.bbabio.2012.05.011_bb0015","doi-asserted-by":"crossref","first-page":"18558","DOI":"10.1074\/jbc.C500089200","article-title":"Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D","volume":"280","author":"Basso","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbabio.2012.05.011_bb0020","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/nature03317","article-title":"Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death","volume":"434","author":"Nakagawa","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.bbabio.2012.05.011_bb0025","doi-asserted-by":"crossref","first-page":"12005","DOI":"10.1073\/pnas.0505294102","article-title":"Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia","volume":"102","author":"Schinzel","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbabio.2012.05.011_bb0030","doi-asserted-by":"crossref","first-page":"8172","DOI":"10.1021\/bi9525177","article-title":"Chaotropic agents and increased matrix volume enhance binding of mitochondrial cyclophilin to the inner mitochondrial membrane and sensitize the mitochondrial permeability transition to [Ca2+]","volume":"35","author":"Connern","year":"1996","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbabio.2012.05.011_bb0035","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1074\/jbc.271.4.2185","article-title":"Interactions of cyclophilin with the mitochondrial inner membrane and regulation of the permeability transition pore, and cyclosporin A-sensitive channel","volume":"271","author":"Nicolli","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbabio.2012.05.011_bb0040","doi-asserted-by":"crossref","first-page":"26307","DOI":"10.1074\/jbc.C800132200","article-title":"Phosphate is essential for inhibition of the mitochondrial permeability transition pore by cyclosporin A and by cyclophilin D ablation","volume":"283","author":"Basso","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbabio.2012.05.011_bb0045","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0962-8924(00)01803-1","article-title":"Mitochondria as the central control point of apoptosis","volume":"10","author":"Desagher","year":"2000","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.bbabio.2012.05.011_bb0050","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1056\/NEJMoa071142","article-title":"Effect of cyclosporine on reperfusion injury in acute myocardial infarction","volume":"359","author":"Piot","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbabio.2012.05.011_bb0055","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.2337\/diabetes.54.7.2179","article-title":"Metformin prevents high-glucose-induced endothelial cell death through a mitochondrial permeability transition-dependent process","volume":"54","author":"Detaille","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.bbabio.2012.05.011_bb0060","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1074\/jbc.275.1.223","article-title":"Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I","volume":"275","author":"El-Mir","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbabio.2012.05.011_bb0065","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1042\/BJ20040885","article-title":"Metformin inhibits mitochondrial permeability transition and cell death: a pharmacological in vitro study","volume":"382","author":"Guigas","year":"2004","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbabio.2012.05.011_bb0070","doi-asserted-by":"crossref","first-page":"41394","DOI":"10.1074\/jbc.M106417200","article-title":"Rotenone inhibits the mitochondrial permeability transition-induced cell death in U937 and KB cells","volume":"276","author":"Chauvin","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbabio.2012.05.011_bb0075","doi-asserted-by":"crossref","first-page":"e134","DOI":"10.1038\/cddis.2011.15","article-title":"Protection of pancreatic INS-1 beta-cells from glucose- and fructose-induced cell death by inhibiting mitochondrial permeability transition with cyclosporin A or metformin","volume":"2","author":"Lablanche","year":"2011","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbabio.2012.05.011_bb0080","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1432-1033.1982.tb05851.x","article-title":"Intracellular compartmentation and control of alanine metabolism in rat liver parenchymal cells","volume":"122","author":"Groen","year":"1982","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.bbabio.2012.05.011_bb0085","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1023\/A:1005572731059","article-title":"Calcium-binding properties of the mitochondrial channel-forming hydrophobic component","volume":"32","author":"Gateau-Roesch","year":"2000","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.bbabio.2012.05.011_bb0090","first-page":"4970","article-title":"Characterization of a human ovarian adenocarcinoma line, IGROV1, in tissue culture and in nude mice","volume":"45","author":"Benard","year":"1985","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbabio.2012.05.011_bb0095","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/jnr.490260302","article-title":"Establishment of permanent astroglial cell lines, able to differentiate in vitro, from transgenic mice carrying the polyoma virus large T gene: an alternative approach to brain cell immortalization","volume":"26","author":"Galiana","year":"1990","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bbabio.2012.05.011_bb0100","doi-asserted-by":"crossref","first-page":"12662","DOI":"10.1074\/jbc.273.20.12662","article-title":"Regulation of the permeability transition pore in skeletal muscle mitochondria. Modulation by electron flow through the respiratory chain complex i","volume":"273","author":"Fontaine","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbabio.2012.05.011_bb0105","doi-asserted-by":"crossref","first-page":"25734","DOI":"10.1074\/jbc.273.40.25734","article-title":"A ubiquinone-binding site regulates the mitochondrial permeability transition pore","volume":"273","author":"Fontaine","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbabio.2012.05.011_bb0110","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1152\/physrev.1999.79.4.1127","article-title":"Mitochondrial transport of cations: channels, exchangers, and permeability transition","volume":"79","author":"Bernardi","year":"1999","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbabio.2012.05.011_bb0115","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1126\/science.1099320","article-title":"The pathophysiology of mitochondrial cell death","volume":"305","author":"Green","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.bbabio.2012.05.011_bb0120","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.bbabio.2009.12.006","article-title":"Cyclophilin D in mitochondrial pathophysiology","volume":"1797","author":"Giorgio","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbabio.2012.05.011_bb0125","doi-asserted-by":"crossref","first-page":"33982","DOI":"10.1074\/jbc.M109.020115","article-title":"Cyclophilin D modulates mitochondrial F0F1-ATP synthase by interacting with the lateral stalk of the complex","volume":"284","author":"Giorgio","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"Pt 2","key":"10.1016\/j.bbabio.2012.05.011_bb0130","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1042\/bj3360287","article-title":"Direct demonstration of a specific interaction between cyclophilin-D and the adenine nucleotide translocase confirms their role in the mitochondrial permeability transition","volume":"336","author":"Woodfield","year":"1998","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbabio.2012.05.011_bb0135","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/nature02229","article-title":"The ADP\/ATP translocator is not essential for the mitochondrial permeability transition pore","volume":"427","author":"Kokoszka","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.bbabio.2012.05.011_bb0140","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.cell.2007.08.028","article-title":"Regulation of tumor cell mitochondrial homeostasis by an organelle-specific Hsp90 chaperone network","volume":"131","author":"Kang","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.bbabio.2012.05.011_bb0145","doi-asserted-by":"crossref","first-page":"9692","DOI":"10.1074\/jbc.M808750200","article-title":"Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic effect","volume":"284","author":"Eliseev","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbabio.2012.05.011_bb0150","doi-asserted-by":"crossref","first-page":"9038","DOI":"10.1074\/jbc.M009661200","article-title":"Catalytic activity of NADH-ubiquinone oxidoreductase (complex I) in intact mitochondria. evidence for the slow active\/inactive transition","volume":"276","author":"Grivennikova","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbabio.2012.05.011_bb0155","doi-asserted-by":"crossref","first-page":"10971","DOI":"10.1021\/bi7009822","article-title":"Redox-dependent change of nucleotide affinity to the active site of the mammalian complex I","volume":"46","author":"Grivennikova","year":"2007","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbabio.2012.05.011_bb0160","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1080\/15216540152845920","article-title":"The mitochondrial complex I: progress in understanding of catalytic properties","volume":"52","author":"Vinogradov","year":"2001","journal-title":"IUBMB Life"},{"key":"10.1016\/j.bbabio.2012.05.011_bb0165","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.bbabio.2004.03.016","article-title":"Inhibition of mitochondrial respiratory complex I by nitric oxide, peroxynitrite and S-nitrosothiols","volume":"1658","author":"Brown","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbabio.2012.05.011_bb0170","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.bbabio.2010.03.013","article-title":"cAMP-dependent protein kinase regulates post-translational processing and expression of complex I subunits in mammalian cells","volume":"1797","author":"Papa","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbabio.2012.05.011_bb0175","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2337\/dc08-9025","article-title":"Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes","volume":"32","author":"Nathan","year":"2009","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bbabio.2012.05.011_bb0180","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1463-1326.2010.01349.x","article-title":"Effect of metformin on cardiovascular events and mortality: a meta-analysis of randomized clinical trials","volume":"13","author":"Lamanna","year":"2011","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.bbabio.2012.05.011_bb0185","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1001\/archinte.168.19.2070","article-title":"Cardiovascular outcomes in trials of oral diabetes medications: a systematic review","volume":"168","author":"Selvin","year":"2008","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.bbabio.2012.05.011_bb0190","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1042\/CS20110386","article-title":"Cellular and molecular mechanisms of metformin: an overview","volume":"122","author":"Viollet","year":"2012","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.bbabio.2012.05.011_bb0195","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1172\/JCI40671","article-title":"Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1\/AMPK pathway via a decrease in hepatic energy state","volume":"120","author":"Foretz","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbabio.2012.05.011_bb0200","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1038\/sj.bjp.0707189","article-title":"Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer","volume":"150","author":"Hinke","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbabio.2012.05.011_bb0205","doi-asserted-by":"crossref","first-page":"10214","DOI":"10.1073\/pnas.0914209107","article-title":"Targeting cyclophilin D and the mitochondrial permeability transition enhances beta-cell survival and prevents diabetes in Pdx1 deficiency","volume":"107","author":"Fujimoto","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbabio.2012.05.011_bb0210","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1101\/gad.12.12.1763","article-title":"Beta-cell-specific inactivation of the mouse Ipf1\/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes","volume":"12","author":"Ahlgren","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbabio.2012.05.011_bb0215","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1172\/JCI200316537","article-title":"Increased islet apoptosis in Pdx1+\/\u2212 mice","volume":"111","author":"Johnson","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbabio.2012.05.011_bb0220","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1172\/JCI21845","article-title":"PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance","volume":"114","author":"Kulkarni","year":"2004","journal-title":"J. Clin. Invest."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Bioenergetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0005272812001685?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0005272812001685?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T13:39:22Z","timestamp":1762090762000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0005272812001685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":44,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["S0005272812001685"],"URL":"https:\/\/doi.org\/10.1016\/j.bbabio.2012.05.011","relation":{},"ISSN":["0005-2728"],"issn-type":[{"value":"0005-2728","type":"print"}],"subject":[],"published":{"date-parts":[[2012,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of complex I regulates the mitochondrial permeability transition through a phosphate-sensitive inhibitory site masked by cyclophilin D","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Bioenergetics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbabio.2012.05.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}