{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:44:59Z","timestamp":1791215099947,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,3,10]],"date-time":"2015-03-10T00:00:00Z","timestamp":1425945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["BBA Clinical"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1016\/j.bbacli.2015.03.004","type":"journal-article","created":{"date-parts":[[2015,3,14]],"date-time":"2015-03-14T12:41:18Z","timestamp":1426336878000},"page":"251-256","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["Calcitriol\/calcifediol ratio: An indicator of vitamin D hydroxylation efficiency?"],"prefix":"10.1016","volume":"3","author":[{"given":"Marzia","family":"Pasquali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lida","family":"Tartaglione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silverio","family":"Rotondi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luisa","family":"Muci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giusi","family":"Mandanici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Farcomeni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martino","family":"Marangella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro","family":"Mazzaferro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbacli.2015.03.004_bb0005","series-title":"Vitamin D","first-page":"23","article-title":"The Activating Enzymes of Vitamin D Metabolism (25- and 1 alpha-Hydroxylases)","author":"Jones","year":"2011"},{"issue":"12","key":"10.1016\/j.bbacli.2015.03.004_bb0010","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.tibs.2004.10.005","article-title":"Enzymes involved in the activation and inactivation of vitamin D","volume":"29","author":"Prosser","year":"2004","journal-title":"Trends Biochem. Sci."},{"issue":"2","key":"10.1016\/j.bbacli.2015.03.004_bb0015","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1271\/bbb.100684","article-title":"The vitamin D3 1alpha-hydroxylase gene and its regulation by active vitamin D3","volume":"75","author":"Takeyama","year":"2011","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.bbacli.2015.03.004_bb0020","series-title":"Vitamin D","first-page":"43","article-title":"CYP24A1: Structure, Function, and Physiological Role","author":"St-Arnaud","year":"2011"},{"issue":"2","key":"10.1016\/j.bbacli.2015.03.004_bb0025","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1002\/jcb.10365","article-title":"Inhibitors of vitamin D hydroxylases: structure\u2013activity relationships","volume":"88","author":"Schuster","year":"2003","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bbacli.2015.03.004_bb0030","series-title":"Vitamin D","first-page":"43","article-title":"Drug and Hormone Effects on Vitamin D Metabolism","author":"Weinstein","year":"2011"},{"issue":"4","key":"10.1016\/j.bbacli.2015.03.004_bb0035","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/j.1365-2265.1982.tb00725.x","article-title":"Demonstration of circulating 1,24,25-trihydroxyvitamin D3 in man by radioimmunoassay","volume":"16","author":"Clemens","year":"1982","journal-title":"Clin. Endocrinol."},{"issue":"4","key":"10.1016\/j.bbacli.2015.03.004_bb0040","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/j.1525-139X.2005.18402.x","article-title":"Vitamin D for health and in chronic kidney disease","volume":"18","author":"Holick","year":"2005","journal-title":"Semin. Dial."},{"issue":"4","key":"10.1016\/j.bbacli.2015.03.004_bb0045","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.beem.2011.05.005","article-title":"Vitamin D","volume":"25","author":"Dusso","year":"2011","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.bbacli.2015.03.004_bb0050","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1210\/jc.2009-1773","article-title":"Update in vitamin D","volume":"95","author":"Adams","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.bbacli.2015.03.004_bb0055","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/sj.ki.5002009","article-title":"Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: results of the study to evaluate early kidney disease","volume":"71","author":"Levin","year":"2007","journal-title":"Kidney Int."},{"issue":"9","key":"10.1016\/j.bbacli.2015.03.004_bb0060","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.yexcr.2012.02.027","article-title":"Role of FGF23 in vitamin D and phosphate metabolism: implications in chronic kidney disease","volume":"318","author":"Quarles","year":"2012","journal-title":"Exp. Cell Res."},{"issue":"10","key":"10.1016\/j.bbacli.2015.03.004_bb0065","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1681\/ASN.2006070783","article-title":"Parathyroid hormone regulates fibroblast growth factor-23 in a mouse model of primary hyperparathyroidism","volume":"18","author":"Kawata","year":"2007","journal-title":"J. Am. Soc. Nephrol."},{"issue":"1","key":"10.1016\/j.bbacli.2015.03.004_bb0070","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1530\/eje.1.02053","article-title":"Regulation of plasma fibroblast growth factor 23 by calcium in primary hyperparathyroidism","volume":"154","author":"Kobayashi","year":"2006","journal-title":"Eur. J. Endocrinol."},{"issue":"1","key":"10.1016\/j.bbacli.2015.03.004_bb0075","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1530\/EJE-11-0523","article-title":"Increased circulating levels of FGF23: an adaptive response in primary hyperparathyroidism?","volume":"166","author":"Witteveen","year":"2012","journal-title":"Eur. J. Endocrinol."},{"issue":"1","key":"10.1016\/j.bbacli.2015.03.004_bb0080","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1365-2265.2006.02680.x","article-title":"Plasma 1,25-dihydroxyvitamin D levels in primary hyperparathyroidism depend on sex, body mass index, plasma phosphate and renal function","volume":"66","author":"Moosgaard","year":"2007","journal-title":"Clin. Endocrinol.(Oxf)"},{"key":"10.1016\/j.bbacli.2015.03.004_bb0085","first-page":"856747","article-title":"Is vitamin D insufficiency associated with mortality of critically ill patients?","volume":"2013","author":"Aygencel","year":"2013","journal-title":"Crit. Care Res. Pract."},{"issue":"4","key":"10.1016\/j.bbacli.2015.03.004_bb0090","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1007\/s10552-013-0158-4","article-title":"Associations of serum 25-hydroxyvitamin D with overall and breast cancer-specific mortality in a multiethnic cohort of breast cancer survivors","volume":"24","author":"Villasenor","year":"2013","journal-title":"Cancer Causes Control"},{"issue":"12","key":"10.1016\/j.bbacli.2015.03.004_bb0095","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1001\/archinte.168.12.1340","article-title":"Independent association of low serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels with all-cause and cardiovascular mortality","volume":"168","author":"Dobnig","year":"2008","journal-title":"Arch. Intern. Med."},{"issue":"10","key":"10.1016\/j.bbacli.2015.03.004_bb0100","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1002\/art.24785","article-title":"25-hydroxyvitamin D and cardiovascular risk factors in women with systemic lupus erythematosus","volume":"61","author":"Wu","year":"2009","journal-title":"Arthritis Rheum."},{"issue":"18","key":"10.1016\/j.bbacli.2015.03.004_bb0105","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1093\/eurheartj\/ehs426","article-title":"Vitamin D and risk of death from vascular and non-vascular causes in the Whitehall study and meta-analyses of 12,000 deaths","volume":"34","author":"Tomson","year":"2013","journal-title":"Eur. Heart J."},{"issue":"11","key":"10.1016\/j.bbacli.2015.03.004_bb0110","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1161\/ATVBAHA.112.248039","article-title":"25-hydroxyvitamin D levels and risk of ischemic heart disease, myocardial infarction, and early death: population-based study and meta-analyses of 18 and 17 studies","volume":"32","author":"Brondum-Jacobsen","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"5","key":"10.1016\/j.bbacli.2015.03.004_bb0115","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1111\/j.1365-2265.2009.03548.x","article-title":"Vitamin D and mortality in older men and women","volume":"71","author":"Pilz","year":"2009","journal-title":"Clin. Endocrinol. (Oxf)"},{"issue":"15","key":"10.1016\/j.bbacli.2015.03.004_bb0120","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1001\/archinte.168.15.1629","article-title":"25-hydroxyvitamin D levels and the risk of mortality in the general population","volume":"168","author":"Melamed","year":"2008","journal-title":"Arch. Intern. Med."},{"issue":"1","key":"10.1016\/j.bbacli.2015.03.004_bb0125","doi-asserted-by":"crossref","first-page":"51","DOI":"10.4161\/derm.24494","article-title":"Sunlight and Vitamin D: a global perspective for health","volume":"5","author":"Wacker","year":"2013","journal-title":"Dermatoendocrinol"},{"issue":"6","key":"10.1016\/j.bbacli.2015.03.004_bb0130","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.2215\/CJN.08610812","article-title":"Calcium absorption response to cholecalciferol supplementation in hemodialysis","volume":"8","author":"Armas","year":"2013","journal-title":"Clin. J. Am. Soc. Nephrol."},{"issue":"7","key":"10.1016\/j.bbacli.2015.03.004_bb0135","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.2215\/CJN.02840312","article-title":"Effects of cholecalciferol on functional, biochemical, vascular, and quality of life outcomes in hemodialysis patients","volume":"8","author":"Hewitt","year":"2013","journal-title":"Clin. J. Am. Soc. Nephrol."},{"issue":"6","key":"10.1016\/j.bbacli.2015.03.004_bb0140","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/ki.2008.549","article-title":"Effects of vitamin D supplementation on the calcium-phosphate balance in renal transplant patients","volume":"75","author":"Courbebaisse","year":"2009","journal-title":"Kidney Int."}],"container-title":["BBA Clinical"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214647415000185?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214647415000185?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T06:26:09Z","timestamp":1537770369000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214647415000185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":28,"alternative-id":["S2214647415000185"],"URL":"https:\/\/doi.org\/10.1016\/j.bbacli.2015.03.004","relation":{},"ISSN":["2214-6474"],"issn-type":[{"value":"2214-6474","type":"print"}],"subject":[],"published":{"date-parts":[[2015,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Calcitriol\/calcifediol ratio: An indicator of vitamin D hydroxylation efficiency?","name":"articletitle","label":"Article Title"},{"value":"BBA Clinical","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbacli.2015.03.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}