{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:48:02Z","timestamp":1790837282255,"version":"4.1.0"},"reference-count":118,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,4,27]],"date-time":"2016-04-27T00:00:00Z","timestamp":1461715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["BBA Clinical"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.bbacli.2016.04.006","type":"journal-article","created":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T04:35:18Z","timestamp":1462077318000},"page":"165-176","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"special_numbering":"C","title":["Signaling mechanisms implicated in cranial sutures pathophysiology: Craniosynostosis"],"prefix":"10.1016","volume":"6","author":[{"given":"Maria A.","family":"Katsianou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Adamopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heleni","family":"Vastardis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efthimia K.","family":"Basdra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbacli.2016.04.006_bb0005","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.ajhg.2015.07.006","article-title":"A genetic-pathophysiological framework for craniosynostosis","volume":"97","author":"Twigg","year":"2015","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0010","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/1097-0177(2000)9999:9999<::AID-DVDY1073>3.0.CO;2-F","article-title":"Cranial sutures as intramembranous bone growth sites","volume":"219","author":"Opperman","year":"2000","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0015","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.yexcr.2014.01.019","article-title":"Neural crest cell signaling pathways critical to cranial bone development and pathology","volume":"325","author":"Mishina","year":"2014","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0020","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/j.1469-7580.2005.00473.x","article-title":"Relations and interactions between cranial mesoderm and neural crest populations","volume":"207","author":"Noden","year":"2005","journal-title":"J. Anat."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0025","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1006\/dbio.2001.0487","article-title":"Tissue origins and interactions in the mammalian skull vault","volume":"241","author":"Jiang","year":"2002","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0030","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1006\/dbio.1999.9323","article-title":"A novel transgenic technique that allows specific marking of the neural crest cell lineage in mice","volume":"212","author":"Yamauchi","year":"1999","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0035","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.mod.2008.06.007","article-title":"Cell lineage in mammalian craniofacial mesenchyme","volume":"125","author":"Yoshida","year":"2008","journal-title":"Mech. Dev."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0040","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1159\/000115031","article-title":"Mechanical influences on suture development and patency","volume":"12","author":"Herring","year":"2008","journal-title":"Front. Oral Biol."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0045","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/j.1601-0825.2005.01176.x","article-title":"FGF signalling in craniofacial development and developmental disorders","volume":"12","author":"Nie","year":"2006","journal-title":"Oral Dis."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0050","doi-asserted-by":"crossref","first-page":"170e","DOI":"10.1097\/01.prs.0000304441.99483.97","article-title":"Cranial sutures: a brief review","volume":"121","author":"Slater","year":"2008","journal-title":"Plast. Reconstr. Surg."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0055","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1002\/ar.22474","article-title":"Changes in biomechanical strain and morphology of rat calvarial sutures and bone after Tgf-beta3 inhibition of posterior interfrontal suture fusion","volume":"295","author":"Shibazaki-Yorozuya","year":"2012","journal-title":"Anat. Rec. (Hoboken)"},{"key":"10.1016\/j.bbacli.2016.04.006_bb0060","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1159\/000145785","article-title":"Skull morphogenesis and growth: hemodynamic influence","volume":"117","author":"Oudhof","year":"1983","journal-title":"Acta Anat. (Basel)"},{"key":"10.1016\/j.bbacli.2016.04.006_bb0065","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1002\/jbmr.5650101218","article-title":"Cranial sutures require tissue interactions with dura mater to resist osseous obliteration in vitro","volume":"10","author":"Opperman","year":"1995","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0070","article-title":"Inhibited Wnt signaling causes age-dependent abnormalities in the bone matrix mineralization in the Apert syndrome FGFR2(S252W\/+) mice","volume":"10","author":"Zhang","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.bbacli.2016.04.006_bb0075","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/0889-5406(88)90074-1","article-title":"The effects of force magnitude on a sutural model: a quantitative approach","volume":"93","author":"Southard","year":"1988","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0080","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1097\/PRS.0b013e3181bf806c","article-title":"Force-induced craniosynostosis in the murine sagittal suture","volume":"124","author":"Oppenheimer","year":"2009","journal-title":"Plast. Reconstr. Surg."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0085","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.bone.2007.05.014","article-title":"Responses of intramembranous bone and sutures upon in vivo cyclic tensile and compressive loading","volume":"42","author":"Peptan","year":"2008","journal-title":"Bone"},{"key":"10.1016\/j.bbacli.2016.04.006_bb0090","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1601-6343.2006.00371.x","article-title":"Cellular response to force application at craniofacial sutures","volume":"9","author":"Alaqeel","year":"2006","journal-title":"Orthod. Craniofacial Res."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0095","doi-asserted-by":"crossref","first-page":"20122670","DOI":"10.1098\/rspb.2012.2670","article-title":"A mathematical model for mechanotransduction at the early steps of suture formation","volume":"280","author":"Khonsari","year":"2013","journal-title":"Proc. Biol. Sci."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0100","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.gendis.2014.07.004","article-title":"Molecular basis of cranial suture biology and disease: osteoblastic and osteoclastic perspectives","volume":"1","author":"Beederman","year":"2014","journal-title":"Genes Dis."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0105","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/ajmg.1320550422","article-title":"Genetic study of nonsyndromic coronal craniosynostosis","volume":"55","author":"Lajeunie","year":"1995","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0110","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1159\/000115035","article-title":"Genetics of craniosynostosis: genes, syndromes, mutations and genotype\u2013phenotype correlations","volume":"12","author":"Passos-Bueno","year":"2008","journal-title":"Front. Oral Biol."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0115","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/S0168-9525(03)00176-8","article-title":"Transcriptional mechanisms in osteoblast differentiation and bone formation","volume":"19","author":"Nakashima","year":"2003","journal-title":"Trends Genet."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0120","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1146\/annurev.genet.36.061802.101708","article-title":"Genetics of sensory mechanotransduction","volume":"36","author":"Ernstrom","year":"2002","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0125","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s00401-013-1104-y","article-title":"Hand in glove: brain and skull in development and dysmorphogenesis","volume":"125","author":"Richtsmeier","year":"2013","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0130","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.ajodo.2003.08.024","article-title":"Growth and development: hereditary and mechanical modulations","volume":"125","author":"Mao","year":"2004","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0135","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/ar.1092260404","article-title":"Skeletal structural adaptations to mechanical usage (SATMU): 3. The hyaline cartilage modeling problem","volume":"226","author":"Frost","year":"1990","journal-title":"Anat. Rec."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0140","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s00441-012-1531-4","article-title":"Mechanical cues in cellular signalling and communication","volume":"352","author":"Bukoreshtliev","year":"2013","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0145","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1177\/154405910208101203","article-title":"Mechanobiology of craniofacial sutures","volume":"81","author":"Mao","year":"2002","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0150","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1113\/jphysiol.2014.271346","article-title":"Polycystins and partners: proposed role in mechanosensitivity","volume":"592","author":"Retailleau","year":"2014","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0155","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1002\/ijc.29140","article-title":"Polycystin-1 and polycystin-2 are involved in the acquisition of aggressive phenotypes in colorectal cancer","volume":"136","author":"Gargalionis","year":"2015","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bbacli.2016.04.006_bb0160","doi-asserted-by":"crossref","first-page":"13461","DOI":"10.1038\/srep13461","article-title":"Elevated expression of mechanosensory polycystins in human carotid atherosclerotic plaques: association with p53 activation and disease severity","volume":"5","author":"Varela","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0165","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1007\/BF03401654","article-title":"Characterization and cell distribution of polycystin, the product of autosomal dominant polycystic kidney disease gene 1","volume":"2","author":"Palsson","year":"1996","journal-title":"Mol. Med."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0170","doi-asserted-by":"crossref","first-page":"40723","DOI":"10.1074\/jbc.M509650200","article-title":"The nanomechanics of polycystin-1 extracellular region","volume":"280","author":"Qian","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0175","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00018-012-1164-5","article-title":"Mechanical stimulation of polycystin-1 induces human osteoblastic gene expression via potentiation of the calcineurin\/NFAT signaling axis","volume":"70","author":"Dalagiorgou","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0180","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1016\/j.biocel.2010.06.017","article-title":"Polycystin-1: function as a mechanosensor","volume":"42","author":"Dalagiorgou","year":"2010","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0185","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/ncb754","article-title":"Polycystin-2 is an intracellular calcium release channel","volume":"4","author":"Koulen","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0190","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1038\/35050128","article-title":"Co-assembly of polycystin-1 and \u22122 produces unique cation-permeable currents","volume":"408","author":"Hanaoka","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.bbacli.2016.04.006_bb0195","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/nrm3528","article-title":"Exploring mechanisms of FGF signalling through the lens of structural biology","volume":"14","author":"Goetz","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0200","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.gendis.2014.09.005","article-title":"Fibroblast growth factor (FGF) signaling in development and skeletal diseases","volume":"1","author":"Teven","year":"2014","journal-title":"Genes Dis."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0205","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1093\/hmg\/7.9.1475","article-title":"Apert syndrome mutations in fibroblast growth factor receptor 2 exhibit increased affinity for FGF ligand","volume":"7","author":"Anderson","year":"1998","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0210","doi-asserted-by":"crossref","first-page":"14536","DOI":"10.1073\/pnas.97.26.14536","article-title":"Loss of fibroblast growth factor receptor 2 ligand-binding specificity in Apert syndrome","volume":"97","author":"Yu","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0215","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1093\/hmg\/ddh235","article-title":"Biochemical analysis of pathogenic ligand-dependent FGFR2 mutations suggests distinct pathophysiological mechanisms for craniofacial and limb abnormalities","volume":"13","author":"Ibrahimi","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0220","doi-asserted-by":"crossref","first-page":"6361","DOI":"10.1242\/dev.00850","article-title":"Ablation of specific expression domains reveals discrete functions of ectoderm- and endoderm-derived FGF8 during cardiovascular and pharyngeal development","volume":"130","author":"Macatee","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.bbacli.2016.04.006_bb0225","doi-asserted-by":"crossref","first-page":"4843","DOI":"10.1073\/pnas.0400869101","article-title":"Reciprocal relationships between Fgf8 and neural crest cells in facial and forebrain development","volume":"101","author":"Creuzet","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0230","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0925-4773(99)00278-6","article-title":"Expression patterns of Twist and Fgfr1, \u22122 and \u22123 in the developing mouse coronal suture suggest a key role for twist in suture initiation and biogenesis","volume":"91","author":"Johnson","year":"2000","journal-title":"Mech. Dev."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0235","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1093\/hmg\/3.12.2153","article-title":"Linkage of Pfeiffer syndrome to chromosome 8 centromere and evidence for genetic heterogeneity","volume":"3","author":"Robin","year":"1994","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0240","first-page":"555","article-title":"A unique point mutation in the fibroblast growth factor receptor 3 gene (FGFR3) defines a new craniosynostosis syndrome","volume":"60","author":"Muenke","year":"1997","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0245","doi-asserted-by":"crossref","first-page":"12555","DOI":"10.1073\/pnas.0405031101","article-title":"A gain-of-function mutation of Fgfr2c demonstrates the roles of this receptor variant in osteogenesis","volume":"101","author":"Eswarakumar","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0250","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1093\/hmg\/9.13.2001","article-title":"A Pro250Arg substitution in mouse Fgfr1 causes increased expression of Cbfa1 and premature fusion of calvarial sutures","volume":"9","author":"Zhou","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0255","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0070-2153(05)66009-7","article-title":"Cranial suture biology","volume":"66","author":"Lenton","year":"2005","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0260","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1097\/00006534-199805000-00001","article-title":"Studies in cranial suture biology: up-regulation of transforming growth factor-beta1 and basic fibroblast growth factor mRNA correlates with posterior frontal cranial suture fusion in the rat","volume":"101","author":"Most","year":"1998","journal-title":"Plast. Reconstr. Surg."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0265","first-page":"164","article-title":"Cranial suture obliteration is induced by removal of transforming growth factor (TGF)-beta 3 activity and prevented by removal of TGF-beta 2 activity from fetal rat calvaria in vitro","volume":"19","author":"Opperman","year":"1999","journal-title":"J. Craniofac. Genet. Dev. Biol."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0270","first-page":"150","article-title":"Dura mater maintains rat cranial sutures in vitro by regulating suture cell proliferation and collagen production","volume":"18","author":"Opperman","year":"1998","journal-title":"J. Craniofac. Genet. Dev. Biol."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0275","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1034\/j.1600-0544.2002.01179.x","article-title":"Transforming growth factor-beta3 (Tgf-beta3) down-regulates Tgf-beta3 receptor type I (Tbetar-I) during rescue of cranial sutures from osseous obliteration","volume":"5","author":"Opperman","year":"2002","journal-title":"Orthod. Craniofacial Res."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0280","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1002\/dvdy.20656","article-title":"Erk1\/2 signaling is required for Tgf-beta 2-induced suture closure","volume":"235","author":"Opperman","year":"2006","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0285","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1038\/ng.2463","article-title":"A genome-wide association study identifies susceptibility loci for nonsyndromic sagittal craniosynostosis near BMP2 and within BBS9","volume":"44","author":"Justice","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0290","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.bone.2013.04.013","article-title":"Regulation of bone morphogenetic protein signalling and cranial osteogenesis by Gpc1 and Gpc3","volume":"55","author":"Dwivedi","year":"2013","journal-title":"Bone"},{"key":"10.1016\/j.bbacli.2016.04.006_bb0295","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/nature01545","article-title":"The BMP antagonist noggin regulates cranial suture fusion","volume":"422","author":"Warren","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.bbacli.2016.04.006_bb0300","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/0092-8674(93)90379-5","article-title":"A mutation in the homeodomain of the human MSX2 gene in a family affected with autosomal dominant craniosynostosis","volume":"75","author":"Jabs","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.bbacli.2016.04.006_bb0305","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1006\/dbio.1998.9114","article-title":"Msx2 gene dosage influences the number of proliferative osteogenic cells in growth centers of the developing murine skull: a possible mechanism for MSX2-mediated craniosynostosis in humans","volume":"205","author":"Liu","year":"1999","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0310","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/ng0494-348","article-title":"Msx1 deficient mice exhibit cleft palate and abnormalities of craniofacial and tooth development","volume":"6","author":"Satokata","year":"1994","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0315","doi-asserted-by":"crossref","first-page":"6131","DOI":"10.1242\/dev.00793","article-title":"Msx2 and Twist cooperatively control the development of the neural crest-derived skeletogenic mesenchyme of the murine skull vault","volume":"130","author":"Ishii","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.bbacli.2016.04.006_bb0320","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ydbio.2010.04.007","article-title":"Inactivation of Msx1 and Msx2 in neural crest reveals an unexpected role in suppressing heterotopic bone formation in the head","volume":"343","author":"Roybal","year":"2010","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0325","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1146\/annurev.cellbio.20.010403.113126","article-title":"The Wnt signaling pathway in development and disease","volume":"20","author":"Logan","year":"2004","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0330","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1002\/dvdy.21934","article-title":"Expression of WNT signalling pathway genes during chicken craniofacial development","volume":"238","author":"Geetha-Loganathan","year":"2009","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0335","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1242\/dev.037440","article-title":"Lrp6-mediated canonical Wnt signaling is required for lip formation and fusion","volume":"136","author":"Song","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.bbacli.2016.04.006_bb0340","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nm.3074","article-title":"WNT signaling in bone homeostasis and disease: from human mutations to treatments","volume":"19","author":"Baron","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0345","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1242\/dev.128.8.1253","article-title":"Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development","volume":"128","author":"Brault","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.bbacli.2016.04.006_bb0350","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/1471-213X-10-116","article-title":"beta-catenin\/cyclin D1 mediated development of suture mesenchyme in calvarial morphogenesis","volume":"10","author":"Mirando","year":"2010","journal-title":"BMC Dev. Biol."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0355","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1242\/dev.01786","article-title":"The role of Axin2 in calvarial morphogenesis and craniosynostosis","volume":"132","author":"Yu","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.bbacli.2016.04.006_bb0360","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.ydbio.2006.10.018","article-title":"Craniosynostosis caused by Axin2 deficiency is mediated through distinct functions of beta-catenin in proliferation and differentiation","volume":"301","author":"Liu","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0365","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0070240","article-title":"Absence of endochondral ossification and craniosynostosis in posterior frontal cranial sutures of Axin2(\u2212\/\u2212) mice","volume":"8","author":"Behr","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbacli.2016.04.006_bb0370","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/ng0197-42","article-title":"Mutations of the TWIST gene in the Saethre\u2013Chotzen syndrome","volume":"15","author":"el Ghouzzi","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0375","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/ng0197-36","article-title":"Mutations in TWIST, a basic helix\u2013loop\u2013helix transcription factor, in Saethre\u2013Chotzen syndrome","volume":"15","author":"Howard","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0380","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1101\/gad.9.6.686","article-title":"twist is required in head mesenchyme for cranial neural tube morphogenesis","volume":"9","author":"Chen","year":"1995","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0385","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1093\/hmg\/7.6.945","article-title":"The variable expressivity and incomplete penetrance of the twist-null heterozygous mouse phenotype resemble those of human Saethre\u2013Chotzen syndrome","volume":"7","author":"Bourgeois","year":"1998","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0390","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.ydbio.2010.08.010","article-title":"Jagged1 functions downstream of Twist1 in the specification of the coronal suture and the formation of a boundary between osteogenic and non-osteogenic cells","volume":"347","author":"Yen","year":"2010","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0395","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1007\/s00018-014-1801-2","article-title":"Osteoblast dysfunctions in bone diseases: from cellular and molecular mechanisms to therapeutic strategies","volume":"72","author":"Marie","year":"2015","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0400","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1242\/dev.125.7.1241","article-title":"FGF-, BMP- and Shh-mediated signalling pathways in the regulation of cranial suture morphogenesis and calvarial bone development","volume":"125","author":"Kim","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.bbacli.2016.04.006_bb0405","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1242\/dev.127.9.1845","article-title":"Integration of FGF and TWIST in calvarial bone and suture development","volume":"127","author":"Rice","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.bbacli.2016.04.006_bb0410","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/35076601","article-title":"Genetics of craniofacial development and malformation","volume":"2","author":"Wilkie","year":"2001","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0415","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1002\/dvdy.20717","article-title":"Twist1 dimer selection regulates cranial suture patterning and fusion","volume":"235","author":"Connerney","year":"2006","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0420","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.ydbio.2008.03.037","article-title":"Twist1 homodimers enhance FGF responsiveness of the cranial sutures and promote suture closure","volume":"318","author":"Connerney","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0425","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.devcel.2005.02.013","article-title":"Canonical Wnt\/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes","volume":"8","author":"Hill","year":"2005","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bbacli.2016.04.006_bb0430","first-page":"1906","article-title":"Twist is up-regulated in response to Wnt1 and inhibits mouse mammary cell differentiation","volume":"63","author":"Howe","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0435","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1074\/jbc.M504875200","article-title":"The Wnt-inducible transcription factor Twist1 inhibits chondrogenesis","volume":"281","author":"Reinhold","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0440","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1469-7580.2005.00411.x","article-title":"Twist is required for establishment of the mouse coronal suture","volume":"206","author":"Yoshida","year":"2005","journal-title":"J. Anat."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0445","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.ydbio.2010.06.009","article-title":"Differential activation of canonical Wnt signaling determines cranial sutures fate: a novel mechanism for sagittal suture craniosynostosis","volume":"344","author":"Behr","year":"2010","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0450","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2000727","article-title":"The balance of WNT and FGF signaling influences mesenchymal stem cell fate during skeletal development","volume":"3","author":"Maruyama","year":"2010","journal-title":"Sci. Signal."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0455","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.bone.2009.02.018","article-title":"The polycystic kidney disease 1 (Pkd1) gene is required for the responses of osteochondroprogenitor cells to midpalatal suture expansion in mice","volume":"44","author":"Hou","year":"2009","journal-title":"Bone"},{"key":"10.1016\/j.bbacli.2016.04.006_bb0460","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.ydbio.2008.07.005","article-title":"Growth of cranial synchondroses and sutures requires polycystin-1","volume":"321","author":"Kolpakova-Hart","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0465","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1093\/hmg\/ddt041","article-title":"Multiple postnatal craniofacial anomalies are characterized by conditional loss of polycystic kidney disease 2 (Pkd2)","volume":"22","author":"Khonsari","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0470","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1093\/hmg\/ddn208","article-title":"Polycystin-1 C-terminal tail associates with beta-catenin and inhibits canonical Wnt signaling","volume":"17","author":"Lal","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0475","doi-asserted-by":"crossref","first-page":"12174","DOI":"10.1073\/pnas.211191098","article-title":"Cardiovascular, skeletal, and renal defects in mice with a targeted disruption of the Pkd1 gene","volume":"98","author":"Boulter","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0480","doi-asserted-by":"crossref","first-page":"C776","DOI":"10.1152\/ajpcell.00082.2005","article-title":"MAP kinase and calcium signaling mediate fluid flow-induced human mesenchymal stem cell proliferation","volume":"290","author":"Riddle","year":"2006","journal-title":"Am. J. Phys. Cell Physiol."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0485","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/0278-2391(95)90121-3","article-title":"Frontonasal suture expansion in the rabbit using titanium screws","volume":"53","author":"Movassaghi","year":"1995","journal-title":"J. Oral Maxillofac. Surg."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0490","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1177\/154405910208101009","article-title":"Chondrocyte proliferation of the cranial base cartilage upon in vivo mechanical stresses","volume":"81","author":"Wang","year":"2002","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0495","doi-asserted-by":"crossref","first-page":"12624","DOI":"10.1074\/jbc.M710407200","article-title":"Polycystin-1 regulates skeletogenesis through stimulation of the osteoblast-specific transcription factor RUNX2-II","volume":"283","author":"Xiao","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0500","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.bone.2007.11.019","article-title":"A Pro253Arg mutation in fibroblast growth factor receptor 2 (Fgfr2) causes skeleton malformation mimicking human Apert syndrome by affecting both chondrogenesis and osteogenesis","volume":"42","author":"Yin","year":"2008","journal-title":"Bone"},{"key":"10.1016\/j.bbacli.2016.04.006_bb0505","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1038\/ng2096","article-title":"RNA interference and inhibition of MEK\u2013ERK signaling prevent abnormal skeletal phenotypes in a mouse model of craniosynostosis","volume":"39","author":"Shukla","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0510","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0014033","article-title":"Activation of FGF signaling mediates proliferative and osteogenic differences between neural crest derived frontal and mesoderm parietal derived bone","volume":"5","author":"Li","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.bbacli.2016.04.006_bb0515","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1006\/excr.2000.4820","article-title":"The Ser252Trp fibroblast growth factor receptor-2 (FGFR-2) mutation induces PKC-independent downregulation of FGFR-2 associated with premature calvaria osteoblast differentiation","volume":"256","author":"Lemonnier","year":"2000","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0520","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1359\/jbmr.2001.16.5.832","article-title":"Role of N-cadherin and protein kinase C in osteoblast gene activation induced by the S252W fibroblast growth factor receptor 2 mutation in Apert craniosynostosis","volume":"16","author":"Lemonnier","year":"2001","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0525","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1359\/jbmr.2001.16.4.705","article-title":"Increased expression of protein kinase Calpha, interleukin-1alpha, and RhoA guanosine 5\u2032-triphosphatase in osteoblasts expressing the Ser252Trp fibroblast growth factor 2 receptor Apert mutation: identification by analysis of complementary DNA microarray","volume":"16","author":"Lomri","year":"2001","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0530","doi-asserted-by":"crossref","first-page":"4897","DOI":"10.1074\/jbc.M805432200","article-title":"Fibroblast growth factor receptor 2 promotes osteogenic differentiation in mesenchymal cells via ERK1\/2 and protein kinase C signaling","volume":"284","author":"Miraoui","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0535","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0002-9440(10)63987-9","article-title":"In vivo modulation of FGF biological activity alters cranial suture fate","volume":"158","author":"Greenwald","year":"2001","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0540","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1227\/01.NEU.0000224323.53866.1E","article-title":"A model for the pharmacological treatment of crouzon syndrome","volume":"59","author":"Perlyn","year":"2006","journal-title":"Neurosurgery"},{"key":"10.1016\/j.bbacli.2016.04.006_bb0545","doi-asserted-by":"crossref","first-page":"18603","DOI":"10.1073\/pnas.0609157103","article-title":"Attenuation of signaling pathways stimulated by pathologically activated FGF-receptor 2 mutants prevents craniosynostosis","volume":"103","author":"Eswarakumar","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0550","doi-asserted-by":"crossref","first-page":"6924","DOI":"10.1074\/jbc.M512932200","article-title":"Inhibition or activation of Apert syndrome FGFR2 (S252W) signaling by specific glycosaminoglycans","volume":"281","author":"McDowell","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0555","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/j.1601-6343.2009.01460.x","article-title":"Medical treatment of craniosynostosis: recombinant Noggin inhibits coronal suture closure in the rat craniosynostosis model","volume":"12","author":"Shen","year":"2009","journal-title":"Orthod. Craniofacial Res."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0560","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1359\/jbmr.070410","article-title":"Noggin inhibits postoperative resynostosis in craniosynostotic rabbits","volume":"22","author":"Cooper","year":"2007","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0565","doi-asserted-by":"crossref","first-page":"94S","DOI":"10.1097\/PRS.0b013e318191c05b","article-title":"Ex vivo Noggin gene therapy inhibits bone formation in a mouse model of postoperative resynostosis","volume":"123","author":"Cooper","year":"2009","journal-title":"Plast. Reconstr. Surg."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0570","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1097\/00006534-199604000-00001","article-title":"Studies in cranial suture biology: part II. Role of the dura in cranial suture fusion","volume":"97","author":"Roth","year":"1996","journal-title":"Plast. Reconstr. Surg."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0575","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1359\/jbmr.1997.12.3.311","article-title":"Studies in cranial suture biology: Part I. Increased immunoreactivity for TGF-beta isoforms (beta 1, beta 2, and beta 3) during rat cranial suture fusion","volume":"12","author":"Roth","year":"1997","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0580","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1597\/07-095.1","article-title":"Comparison of craniofacial phenotype in craniosynostotic rabbits treated with anti-Tgf-beta2 at suturectomy site","volume":"45","author":"Frazier","year":"2008","journal-title":"Cleft Palate Craniofac. J."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0585","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1359\/jbmr.1997.12.3.301","article-title":"TGF-beta 1, TGF-beta 2, and TGF-beta 3 exhibit distinct patterns of expression during cranial suture formation and obliteration in vivo and in vitro","volume":"12","author":"Opperman","year":"1997","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bbacli.2016.04.006_bb0590","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1097\/PRS.0b013e3181b98947","article-title":"TGF-beta1 RNA interference in mouse primary dura cell culture: downstream effects on TGF receptors, FGF-2, and FGF-R1 mRNA levels","volume":"124","author":"Gosain","year":"2009","journal-title":"Plast. Reconstr. Surg."}],"container-title":["BBA Clinical"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214647416300204?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214647416300204?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,19]],"date-time":"2022-06-19T13:26:53Z","timestamp":1655645213000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214647416300204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":118,"alternative-id":["S2214647416300204"],"URL":"https:\/\/doi.org\/10.1016\/j.bbacli.2016.04.006","relation":{},"ISSN":["2214-6474"],"issn-type":[{"value":"2214-6474","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Signaling mechanisms implicated in cranial sutures pathophysiology: Craniosynostosis","name":"articletitle","label":"Article Title"},{"value":"BBA Clinical","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbacli.2016.04.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}