{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:49:47Z","timestamp":1790999387953,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2003,10,1]],"date-time":"2003-10-01T00:00:00Z","timestamp":1064966400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":3613,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2003,10]]},"DOI":"10.1016\/j.bbadis.2003.08.002","type":"journal-article","created":{"date-parts":[[2003,9,12]],"date-time":"2003-09-12T09:20:58Z","timestamp":1063358458000},"page":"121-132","source":"Crossref","is-referenced-by-count":139,"title":["Increased formation of methylglyoxal and protein glycation, oxidation and nitrosation in triosephosphate isomerase deficiency"],"prefix":"10.1016","volume":"1639","author":[{"given":"Naila","family":"Ahmed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinan","family":"Battah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Karachalias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roya","family":"Babaei-Jadidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margit","family":"Hor\u00e1nyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kl\u00e1ra","family":"Bar\u00f3ti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Hollan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Thornalley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2003.08.002_BIB1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1053\/beha.2000.0061","article-title":"Triosephosphate isomerase deficiency: historical perspectives and molecular aspects","volume":"13","author":"Schneider","year":"2000","journal-title":"Bailliere's Clin. Haematol."},{"key":"10.1016\/j.bbadis.2003.08.002_BIB2","doi-asserted-by":"crossref","first-page":"7903","DOI":"10.1073\/pnas.83.20.7903","article-title":"Human triose-phosphate isomerase deficiency: a single amino acid substitution results in a thermolabile enzyme","volume":"83","author":"Daar","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2003.08.002_BIB3","first-page":"1260","article-title":"Human triosephosphate isomerase deficiency resulting from mutations of the Phe-240","volume":"52","author":"Chang","year":"1993","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bbadis.2003.08.002_BIB4","first-page":"245","article-title":"Identical germ-line mutations in the triosephosphate isomerase alleles of two brothers are associated with distinct clinical phenotypes","volume":"323","author":"Valentin","year":"2000","journal-title":"Life Sci."},{"key":"10.1016\/j.bbadis.2003.08.002_BIB5","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1007\/BF00216456","article-title":"Hereditary triosephosphate isomerase (TPI) deficiency: two severely affected brothers one with and one without neurological problems","volume":"92","author":"Hollan","year":"1993","journal-title":"Hum. Genet."},{"key":"10.1016\/j.bbadis.2003.08.002_BIB6","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1006\/bcmd.1996.0011","article-title":"Hematologically important mutations: triosephosphate isomerase","volume":"22","author":"Schneider","year":"1996","journal-title":"Blood Cells Mol. Diseases"},{"key":"10.1016\/j.bbadis.2003.08.002_BIB7","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0002-9343(66)90004-0","article-title":"Hereditary hemolytic anemia with triosephosphate isomerase deficiency: studies in kindreds with coexistent sickle cell trait and erythrocyte glucose-6-phosphate dehydrogenase deficiency","volume":"41","author":"Valentine","year":"1966","journal-title":"Am. J. Med."},{"key":"10.1016\/j.bbadis.2003.08.002_BIB8","series-title":"Erythrocyte Carbohydrate Metabolism and Preliminary Studies of the Erythrocyte Enzyme","first-page":"273","article-title":"Triosephosphate isomerase deficiency. B. Inherited triosephosphate isomerase deficiency","author":"Schneider","year":"1968"},{"key":"10.1016\/j.bbadis.2003.08.002_BIB9","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1006\/bcmd.2000.0280","article-title":"Diminished blood levels of reduced glutathione and \u03b1-tocopherol in two triosephosphate-deficient brothers","volume":"26","author":"Karg","year":"2000","journal-title":"Blood Cells Mol. Diseases"},{"key":"10.1016\/j.bbadis.2003.08.002_BIB10","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1432-1033.1993.tb17638.x","article-title":"The formation of methylglyoxal from triose phosphates. Investigation using a specific assay for methylglyoxal","volume":"212","author":"Phillips","year":"1993","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.bbadis.2003.08.002_BIB11","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0098-2997(93)90002-U","article-title":"The glyoxalase system in health and disease","volume":"14","author":"Thornalley","year":"1993","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.bbadis.2003.08.002_BIB12","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/S0006-2952(99)00132-X","article-title":"Accumulation of \u03b1-oxoaldehydes during oxidative stress. A role in cytotoxicity","volume":"58","author":"Abordo","year":"1999","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbadis.2003.08.002_BIB13","first-page":"263","article-title":"Clinical significance of glycation","volume":"45","author":"Thornalley","year":"1999","journal-title":"Clin. Lab."},{"key":"10.1016\/j.bbadis.2003.08.002_BIB14","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1172\/JCI119885","article-title":"Overexpression of glyoxalase I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycaemia-induced increases in macromolecular endocytosis","volume":"101","author":"Shinohara","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2003.08.002_BIB15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3640001","article-title":"Assay of advanced glycation endproducts (AGEs): surveying AGEs by chromatographic assay with derivatisation by aminoquinolyl-N-hydroxysuccimidyl-carbamate and application to N\u03b5-carboxymethyl-lysine- and N\u03b5-(1-carboxyethyl)lysine-modified albumin","volume":"364","author":"Ahmed","year":"2002","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbadis.2003.08.002_BIB16","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0003-2670(92)85435-9","article-title":"Synthesis and chromatography of 1,2-diamino-4,5-dimethoxybenzene, 6,7-dimethoxy-2-methylquinoxaline and 6,7-dimethoxy-2,3-dimethylquinoxaline for use in a liquid chromatographic fluorimetric assay of methylglyoxal","volume":"263","author":"McLellan","year":"1992","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.bbadis.2003.08.002_BIB17","first-page":"80","article-title":"dl-Methionine sulphoxide","author":"Lapp","year":"1955","journal-title":"Biochem. Prep."},{"key":"10.1016\/j.bbadis.2003.08.002_BIB18","doi-asserted-by":"crossref","first-page":"12341","DOI":"10.1016\/S0021-9258(18)31395-4","article-title":"Formation of o-tyrosine and dityrosine in proteins during radiolytic and metalcatalysed oxidation","volume":"268","author":"Huggins","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2003.08.002_BIB19","doi-asserted-by":"crossref","first-page":"3582","DOI":"10.1021\/bi00875a029","article-title":"Tetranitromethane. A reagent for the nitration of tyrosyl residies in proteins","volume":"5","author":"Sokolovsky","year":"1966","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbadis.2003.08.002_BIB20","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3891\/acta.chem.scand.40b-0235","article-title":"Synthesis of a proposed antigenic hexapeptide from Escherichia-coli k88 protein fimbriae","volume":"40","author":"Meldal","year":"1986","journal-title":"Acta Chem. Scand., Ser. B, Org. Chem. Biochem."},{"key":"10.1016\/j.bbadis.2003.08.002_BIB21","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1002\/hlca.19690520609","article-title":"Le blocage de la lysine par la reaction de Maillard: I. Synthese de N-(desoxy-1-d-fructosyl-1)-et N-(desoxy-1-d-lactulosyl-1)-l-lysine","volume":"52","author":"Finot","year":"1969","journal-title":"Helv. Chim. Acta"},{"key":"10.1016\/j.bbadis.2003.08.002_BIB22","doi-asserted-by":"crossref","first-page":"10362","DOI":"10.1073\/pnas.94.19.10362","article-title":"Search for the pathogenesis of the differing phenotype in two heterozygote Hungarian brothers with the same genotypic triosephosphate isomerase deficiency","volume":"94","author":"Hollan","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2003.08.002_BIB23","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1177\/000456329202900219","article-title":"Sample storage conditions for the assay of glyoxalase activities in whole blood samples","volume":"29","author":"McLellan","year":"1992","journal-title":"Ann. Clin. Biochem."},{"key":"10.1016\/j.bbadis.2003.08.002_BIB24","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0003-2697(05)80004-1","article-title":"Fluorimetric assay of d-lactate","volume":"206","author":"McLellan","year":"1992","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bbadis.2003.08.002_BIB25","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0003-2697(05)80005-3","article-title":"The assay of methylglyoxal in biological systems by derivatization with 1,2-diamino-4,5-dimethoxybenzene","volume":"206","author":"McLellan","year":"1992","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bbadis.2003.08.002_BIB26","doi-asserted-by":"crossref","first-page":"32299","DOI":"10.1016\/S0021-9258(18)31635-1","article-title":"Binding and modification of proteins by methylglyoxal under physiological conditions. A kinetic and mechanistic study with N\u03b1-acetylarginine, N\u03b1-acetylcysteine, N\u03b1-acetyllysine, and bovine serum albumin","volume":"269","author":"Lo","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2003.08.002_BIB27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-4347(01)00196-7","article-title":"Characterization of glycated hemoglobin in diabetic patients: usefulness of electrospray mass spectrometry in monitoring the extent and distribution of glycation","volume":"759","author":"Zhang","year":"2001","journal-title":"J. Chromatogr., B, Biomed. Sci. Appl."},{"key":"10.1016\/j.bbadis.2003.08.002_BIB28","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1006\/abbi.2001.2557","article-title":"NADPH oxidase of neutrophils elevates o,o\u2032-dityrosine crosslinks in proteins and urine during inflammation","volume":"395","author":"Bhattacharjee","year":"2001","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bbadis.2003.08.002_BIB29","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1006\/abbi.2001.2664","article-title":"Peptide methionine sulfoxide reductase: structure, mechanism of action, and biological function","volume":"397","author":"Weissbach","year":"2002","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bbadis.2003.08.002_BIB30","first-page":"1139","article-title":"Chemical modification of proteins by methylglyoxal","volume":"44","author":"Degenhardt","year":"1998","journal-title":"Cell. Mol. Biol."},{"key":"10.1016\/j.bbadis.2003.08.002_BIB31","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/34923","article-title":"Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils","volume":"391","author":"Eiserich","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2003.08.002_BIB32","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1006\/abio.2001.5469","volume":"300","author":"Gaut","year":"2002","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bbadis.2003.08.002_BIB33","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1006\/niox.1997.0141","article-title":"Nitric oxide and peroxynitrite affect differently acetylcholine release, choline acetyltransferase activity, synthesis, and compartmentation of newly formed acetylcholine in Torpedo marmorata synaptosomes","volume":"1","author":"Gaudry-Talarmain","year":"2002","journal-title":"Nitric Oxide-Biol. Chem."},{"key":"10.1016\/j.bbadis.2003.08.002_BIB34","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1042\/bst021163s","article-title":"Formation of methylglyoxal and d-lactate in human red blood cells in vitro","volume":"21","author":"Phillips","year":"1993","journal-title":"Biochem. Soc. Trans."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443903001406?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443903001406?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T20:40:49Z","timestamp":1623357649000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443903001406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,10]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,10]]}},"alternative-id":["S0925443903001406"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2003.08.002","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2003,10]]}}}