{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:33:07Z","timestamp":1790685187766,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2004,5,1]],"date-time":"2004-05-01T00:00:00Z","timestamp":1083369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":3400,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2004,5]]},"DOI":"10.1016\/j.bbadis.2004.01.002","type":"journal-article","created":{"date-parts":[[2004,1,28]],"date-time":"2004-01-28T17:47:27Z","timestamp":1075312047000},"page":"13-21","source":"Crossref","is-referenced-by-count":202,"title":["Low magnesium promotes endothelial cell dysfunction: implications for atherosclerosis, inflammation and thrombosis"],"prefix":"10.1016","volume":"1689","author":[{"given":"Jeanette A.M","family":"Maier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Malpuech-Brug\u00e8re","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wioletta","family":"Zimowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Rayssiguier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Mazur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2004.01.002_BIB1","first-page":"3527","article-title":"Endothelial cells in physiology and in the pathophysiology of vascular disorders","volume":"91","author":"Cines","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.bbadis.2004.01.002_BIB2","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM199901143400207","article-title":"Atherosclerosis\u2014an inflammatory disease","volume":"340","author":"Ross","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbadis.2004.01.002_BIB3","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0092-8674(01)00241-0","article-title":"Molecular mechanisms of human hypertension","volume":"104","author":"Lifton","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2004.01.002_BIB4","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/nm0195-27","article-title":"Angiogenesis in cancer, vascular, rheumatoid and other disease","volume":"1","author":"Folkman","year":"1995","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbadis.2004.01.002_BIB5","series-title":"Advances in Magnesium Research. Nutrition and Health","first-page":"177","article-title":"Epidemiologic data on magnesium-deficiency associated cardiovascular disease and osteoporosis: consideration of risk of current recommendations for high calcium intakes","author":"Seelig","year":"2001"},{"key":"10.1016\/j.bbadis.2004.01.002_BIB6","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S1047-2797(98)00040-4","article-title":"Relationship of serum and dietary magnesium to incident hypertension: the Atherosclerosis Risk in Communities (ARIC) Study","volume":"9","author":"Peacock","year":"1999","journal-title":"Ann. Epidemiol."},{"key":"10.1016\/j.bbadis.2004.01.002_BIB7","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/S0002-8703(98)70224-8","article-title":"Is low magnesium concentration a risk factor for coronary heart disease? The Atherosclerosis Risk in Communities (ARIC) Study","volume":"136","author":"Liao","year":"1998","journal-title":"Am. Heart J."},{"key":"10.1016\/j.bbadis.2004.01.002_BIB8","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1055\/s-0037-1616064","article-title":"Magnesium inhibits arterial thrombi after vascular injury in rat: in vivo impairment of coagulation","volume":"86","author":"Mussoni","year":"2001","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.bbadis.2004.01.002_BIB9","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1161\/hy09t1.095392","article-title":"Insulin-mimetic action of vanadate: role of intracellular magnesium","volume":"38","author":"Barbagallo","year":"2001","journal-title":"Hypertension"},{"key":"10.1016\/j.bbadis.2004.01.002_BIB10","series-title":"Advances in Magnesium Research. Nutrition and Health","first-page":"277","article-title":"Acute phase response in magnesium deficiency: possible relevance to atherosclerosis","author":"Rayssiguier","year":"2001"},{"issue":"5","key":"10.1016\/j.bbadis.2004.01.002_BIB11","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1161\/01.ATV.21.5.858","article-title":"Oral magnesium supplementation induces favorable antiatherogenic changes in ApoE-deficient mice","volume":"21","author":"Ravn","year":"2001","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbadis.2004.01.002_BIB12","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1161\/01.CIR.102.19.2353","article-title":"Oral magnesium therapy improves endothelial function in patients with coronary artery disease","volume":"102","author":"Shechter","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.bbadis.2004.01.002_BIB13","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1001\/archinte.1989.00390050052010","article-title":"Influence of magnesium substitution therapy on blood lipid composition in patients with ischemic heart disease. A double-blind, placebo controlled study","volume":"149","author":"Rasmussen","year":"1989","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.bbadis.2004.01.002_BIB14","doi-asserted-by":"crossref","first-page":"D607","DOI":"10.2741\/Wolf","article-title":"Magnesium in cell proliferation and differentiation","volume":"4","author":"Wolf","year":"1999","journal-title":"Front. Biosci."},{"key":"10.1016\/j.bbadis.2004.01.002_BIB15","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1172\/JCI117644","article-title":"Shifts in the concentrations of magnesium and calcium in early porcine and rat wound fluids activate the cell migratory response","volume":"95","author":"Grzesiak","year":"1995","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2004.01.002_BIB16","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1126\/science.2218499","article-title":"Extension of the life-span of human endothelial cells by an interleukin-1\u03b1 antisense oligomer","volume":"249","author":"Maier","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2004.01.002_BIB17","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1083\/jcb.134.3.783","article-title":"FGF-1-dependent proliferative and migratory responses are impaired in senescent human umbilical vein endothelial cells and correlate with the inability to signal tyrosine phosphorylation of fibroblast growth factor receptor-1 substrates","volume":"134","author":"Garfinkel","year":"1996","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbadis.2004.01.002_BIB18","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1432-1033.1994.tb18712.x","article-title":"The protective role of high-density lipoprotein on oxidized-low-density-lipoprotein-induced U937\/endothelial cell interactions","volume":"221","author":"Maier","year":"1994","journal-title":"Eur. J. Biochem."},{"issue":"10","key":"10.1016\/j.bbadis.2004.01.002_BIB19","doi-asserted-by":"crossref","first-page":"3534","DOI":"10.1097\/00003246-200010000-00031","article-title":"Evaluating the frequency rate of hypomagnesemia in critically ill pediatric patients by using multiple regression analysis and a computer-based neural network","volume":"28","author":"Verive","year":"2000","journal-title":"Crit. Care Med."},{"issue":"5","key":"10.1016\/j.bbadis.2004.01.002_BIB20","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1080\/07315724.1994.10718432","article-title":"Consequences of magnesium deficiency on the enhancement of stress reactions; preventive and therapeutic implications (a review)","volume":"13","author":"Seelig","year":"1994","journal-title":"J. Am. Coll. Nutr."},{"key":"10.1016\/j.bbadis.2004.01.002_BIB21","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0925-4439(00)00018-1","article-title":"Inflammatory response following acute magnesium deficiency in the rat","volume":"1501","author":"Malpuech-Brugere","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2004.01.002_BIB22","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0925-4439(98)00081-7","article-title":"Enhanced tumor necrosis factor\u2014a production following endotoxin challenge in rats is an early event during magnesium deficiency","volume":"1453","author":"Malpuech-Brugere","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2004.01.002_BIB23","doi-asserted-by":"crossref","first-page":"6998","DOI":"10.1073\/pnas.89.15.6998","article-title":"Increased type 1 plasminogen activator inhibitor gene expression in atherosclerotic human arteries","volume":"89","author":"Schneiderman","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2004.01.002_BIB24","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1128\/MCB.14.3.1845","article-title":"Endogenous interleukin 1\u03b1 must be transported to the nucleus to exert its activity in human endothelial cells","volume":"14","author":"Maier","year":"1994","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbadis.2004.01.002_BIB25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0003-9861(92)90086-C","article-title":"Regulation of cell magnesium","volume":"298","author":"Romani","year":"1992","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bbadis.2004.01.002_BIB26","first-page":"1761","article-title":"Effect of Magnesium content on density-dependent regulation of the onset of DNA synthesis in transformed 3T3 cells","volume":"42","author":"Rubin","year":"1982","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbadis.2004.01.002_BIB27","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S0895-7061(00)01271-1","article-title":"Alterations in calcium and magnesium content of red cell membranes in patients with primary hypertension","volume":"14","author":"Kosch","year":"2001","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.bbadis.2004.01.002_BIB28","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1476-5381.1993.tb13568.x","article-title":"Mg2+ and caffeine-induced intracellular Ca2+ release in human vascular endothelial cells","volume":"109","author":"Zhang","year":"1993","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbadis.2004.01.002_BIB29","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1006\/jsre.1996.0229","article-title":"Magnesium is essential in mechanisms of pulmonary vasomotor control","volume":"63","author":"Fullerton","year":"1996","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.bbadis.2004.01.002_BIB30","first-page":"87","article-title":"Combined effects of magnesium deficiency and an atherogenic level of low density lipoprotein on uptake and metabolism of low density lipoprotein by cultured human endothelial cells. I. Biochemical data","volume":"7","author":"Yokoyama","year":"1994","journal-title":"Magnes. Res."},{"key":"10.1016\/j.bbadis.2004.01.002_BIB31","first-page":"183","article-title":"Role of Ca2+ and Mg2+ for endothelial permeability of water and albumin in vitro","volume":"61","author":"Suttorp","year":"1989","journal-title":"Lab. Invest."},{"key":"10.1016\/j.bbadis.2004.01.002_BIB32","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1161\/01.RES.67.3.645","article-title":"Influence of extracellular magnesium on capillary endothelial cell proliferation and migration","volume":"67","author":"Banai","year":"1990","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbadis.2004.01.002_BIB33","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0014-5793(92)81098-7","article-title":"Magnesium deficiency in vitro enhances free radical-induced intracellular oxidation and cytotoxicity in endothelial cells","volume":"311","author":"Dickens","year":"1992","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbadis.2004.01.002_BIB34","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/978-1-4615-4253-7_10","article-title":"Cell cycle regulation by the Cdc25 phosphatase family","volume":"4","author":"Nilsson","year":"2000","journal-title":"Prog. Cell Cycle Res."},{"key":"10.1016\/j.bbadis.2004.01.002_BIB35","doi-asserted-by":"crossref","first-page":"C170","DOI":"10.1152\/ajpcell.1996.270.1.C170","article-title":"Cell cycle arrest in the G2 phase induced by phorbol ester and diacylglycerol in vascular endothelial cells","volume":"270","author":"Kosaka","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bbadis.2004.01.002_BIB36","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/BF00250975","article-title":"Effect of magnesium on the growth and cell cycle of transformed and non-transformed epithelial rat liver cells in vitro","volume":"7","author":"Littlefield","year":"1991","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.bbadis.2004.01.002_BIB37","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/0002-8703(84)90572-6","article-title":"Magnesium: nature's physiologic calcium blocker","volume":"108","author":"Iseri","year":"1984","journal-title":"Am. Heart J."},{"key":"10.1016\/j.bbadis.2004.01.002_BIB38","doi-asserted-by":"crossref","first-page":"3356","DOI":"10.1161\/01.ATV.17.11.3356","article-title":"Differential effects of extracellular Mg2+ on thrombin-induced and capacitative Ca2+ entry in human coronary arterial endothelial cells","volume":"17","author":"Yoshimura","year":"1997","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbadis.2004.01.002_BIB39","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/S0002-9440(10)65369-2","article-title":"Expression of receptor tyrosine kinase Axl and its ligand Gas6 in rheumatoid arthritis: evidence for a novel endothelial cell survival pathway","volume":"154","author":"O'Donnell","year":"1999","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbadis.2004.01.002_BIB40","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1161\/01.RES.83.7.697","article-title":"Increased expression of Axl tyrosine kinase after vascular injury and regulation by G protein-coupled receptor agonists in rats","volume":"83","author":"Melaragno","year":"1998","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbadis.2004.01.002_BIB41","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1023\/A:1016619414817","article-title":"Mg(++)-induced endothelial cell migration: substratum selectivity and receptor-involvement","volume":"4","author":"Lapidos","year":"2001","journal-title":"Angiogenesis"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443904000067?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443904000067?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T02:01:17Z","timestamp":1705024877000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443904000067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5]]},"references-count":41,"aliases":["10.1016\/s0925-4439(04)00006-7"],"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,5]]}},"alternative-id":["S0925443904000067"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2004.01.002","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2004,5]]}}}