{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:21:46Z","timestamp":1791231706625,"version":"4.1.0"},"reference-count":133,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":2274,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2007,6]]},"DOI":"10.1016\/j.bbadis.2006.12.006","type":"journal-article","created":{"date-parts":[[2006,12,16]],"date-time":"2006-12-16T12:14:33Z","timestamp":1166271273000},"page":"681-691","source":"Crossref","is-referenced-by-count":152,"title":["The prion strain phenomenon: Molecular basis and unprecedented features"],"prefix":"10.1016","volume":"1772","author":[{"given":"Rodrigo","family":"Morales","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Abid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Soto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2006.12.006_bib1","doi-asserted-by":"crossref","first-page":"13363","DOI":"10.1073\/pnas.95.23.13363","article-title":"Prions","volume":"95","author":"Prusiner","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2006.12.006_bib2","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1146\/annurev.neuro.24.1.519","article-title":"Prion diseases of humans and animals: their causes and molecular basis","volume":"24","author":"Collinge","year":"2001","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.bbadis.2006.12.006_bib3","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/j.1750-3639.1995.tb00625.x","article-title":"Neuropathological diagnostic criteria for Creutzfeldt\u2013Jakob disease (CJD) and other human spongiform encephalopathies (prion diseases)","volume":"5","author":"Budka","year":"1995","journal-title":"Brain Pathol."},{"key":"10.1016\/j.bbadis.2006.12.006_bib4","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrn1007","article-title":"Unfolding the role of protein misfolding in neurodegenerative diseases","volume":"4","author":"Soto","year":"2003","journal-title":"Nat. Rev., Neurosci."},{"key":"10.1016\/j.bbadis.2006.12.006_bib5","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1093\/ije\/28.3.526","article-title":"When did bovine spongiform encephalopathy (BSE) start? Implications on the prediction of a new variant of Creutzfeldt\u2013Jakob disease (nvCJD) epidemic","volume":"28","author":"Cohen","year":"1999","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.bbadis.2006.12.006_bib6","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/S0140-6736(05)60744-1","article-title":"Estimation of the number of people incubating variant CJD","volume":"352","author":"Ghani","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.bbadis.2006.12.006_bib7","first-page":"77","article-title":"Variant Creutzfeldt\u2013Jakob disease","volume":"42","author":"Will","year":"2004","journal-title":"Folia Neuropathol."},{"key":"10.1016\/j.bbadis.2006.12.006_bib8","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/2151043a0","article-title":"Self-replication and scrapie","volume":"215","author":"Griffith","year":"1967","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2006.12.006_bib9","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1146\/annurev.biochem.67.1.793","article-title":"Pathologic conformations of prion proteins","volume":"67","author":"Cohen","year":"1998","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.bbadis.2006.12.006_bib10","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0092-8674(84)90533-6","article-title":"Purification and structural studies of a major scrapie prion protein","volume":"38","author":"Prusiner","year":"1984","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2006.12.006_bib11","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1126\/science.279.5347.42","article-title":"BSE and prions: uncertainties about the agent","volume":"279","author":"Chesebro","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2006.12.006_bib12","doi-asserted-by":"crossref","first-page":"S63","DOI":"10.1038\/nm1069","article-title":"The controversial protein-only hypothesis of prion propagation","volume":"10","author":"Soto","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbadis.2006.12.006_bib13","doi-asserted-by":"crossref","first-page":"5542","DOI":"10.1128\/JVI.74.12.5542-5547.2000","article-title":"Adaptation and selection of prion protein strain conformations following interspecies transmission of transmissible mink encephalopathy","volume":"74","author":"Bartz","year":"2000","journal-title":"J. Virol."},{"key":"10.1016\/j.bbadis.2006.12.006_bib14","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1110\/ps.39201","article-title":"Strain-specified relative conformational stability of the scrapie prion protein","volume":"10","author":"Peretz","year":"2001","journal-title":"Protein Sci."},{"key":"10.1016\/j.bbadis.2006.12.006_bib15","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0368-1742(61)80013-1","article-title":"Scrapie produced experimentally in goats with special reference to the clinical syndrome","volume":"71","author":"Pattison","year":"1961","journal-title":"J. Comp. Pathol."},{"issue":"Pt 2","key":"10.1016\/j.bbadis.2006.12.006_bib16","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1099\/0022-1317-73-2-329","article-title":"Identification of two biologically distinct strains of transmissible mink encephalopathy in hamsters","volume":"73","author":"Bessen","year":"1992","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.bbadis.2006.12.006_bib17","first-page":"209","article-title":"Scrapie in sheep and goats","volume":"44","author":"Dickinson","year":"1976","journal-title":"Front Biol."},{"key":"10.1016\/j.bbadis.2006.12.006_bib18","doi-asserted-by":"crossref","first-page":"385","DOI":"10.2174\/1566524043360672","article-title":"The genetics of scrapie in sheep and goats","volume":"4","author":"Baylis","year":"2004","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.bbadis.2006.12.006_bib19","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1093\/oxfordjournals.bmb.a072649","article-title":"Scrapie strain variation and mutation","volume":"49","author":"Bruce","year":"1993","journal-title":"Br. Med. Bull."},{"key":"10.1016\/j.bbadis.2006.12.006_bib20","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1093\/oxfordjournals.bmb.a072647","article-title":"Diversity in the neuropathology of scrapie-like diseases in animals","volume":"49","author":"Fraser","year":"1993","journal-title":"Br. Med. Bull."},{"key":"10.1016\/j.bbadis.2006.12.006_bib21","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/0092-8674(87)90134-6","article-title":"Distinct prion proteins in short and long scrapie incubation period mice","volume":"51","author":"Westaway","year":"1987","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2006.12.006_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0304-3940(89)90298-X","article-title":"Precise targeting of the pathology of the sialoglycoprotein, PrP, and vacuolar degeneration in mouse scrapie","volume":"102","author":"Bruce","year":"1989","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbadis.2006.12.006_bib23","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1099\/0022-1317-83-3-695","article-title":"Strain characterization of natural sheep scrapie and comparison with BSE","volume":"83","author":"Bruce","year":"2002","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.bbadis.2006.12.006_bib24","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1099\/0022-1317-77-7-1601","article-title":"Strain specific and common pathogenic events in murine models of scrapie and bovine spongiform encephalopathy","volume":"77","author":"Lasmezas","year":"1996","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.bbadis.2006.12.006_bib25","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0021-9975(73)90024-8","article-title":"Scrapie in mice. Agent-strain differences in the distribution and intensity of grey matter vacuolation","volume":"83","author":"Fraser","year":"1973","journal-title":"J. Comp. Pathol."},{"key":"10.1016\/j.bbadis.2006.12.006_bib26","doi-asserted-by":"crossref","first-page":"15137","DOI":"10.1073\/pnas.96.26.15137","article-title":"Compelling transgenetic evidence for transmission of bovine spongiform encephalopathy prions to humans","volume":"96","author":"Scott","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2006.12.006_bib27","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/39057","article-title":"Transmissions to mice indicate that \u2018new variant\u2019 CJD is caused by the BSE agent","volume":"389","author":"Bruce","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2006.12.006_bib28","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1099\/0022-1317-72-3-595","article-title":"The disease characteristics of different strains of scrapie in Sinc congenic mouse lines: implications for the nature of the agent and host control of pathogenesis","volume":"72","author":"Bruce","year":"1991","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.bbadis.2006.12.006_bib29","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0021-9975(68)90005-4","article-title":"Identification of a gene which controls the incubation period of some strains of scrapie agent in mice","volume":"78","author":"Dickinson","year":"1968","journal-title":"J. Comp. Pathol."},{"key":"10.1016\/j.bbadis.2006.12.006_bib30","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1046\/j.1460-9568.2002.02128.x","article-title":"Early behavioural changes in mice infected with BSE and scrapie: automated home cage monitoring reveals prion strain differences","volume":"16","author":"Dell'Omo","year":"2002","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bbadis.2006.12.006_bib31","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.nbd.2004.08.015","article-title":"Neuropathologically distinct prion strains give rise to similar temporal profiles of behavioral deficits","volume":"18","author":"Cunningham","year":"2005","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbadis.2006.12.006_bib32","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1128\/JVI.66.4.2096-2101.1992","article-title":"Biochemical and physical properties of the prion protein from two strains of the transmissible mink encephalopathy agent","volume":"66","author":"Bessen","year":"1992","journal-title":"J. Virol."},{"key":"10.1016\/j.bbadis.2006.12.006_bib33","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/383685a0","article-title":"Molecular analysis of prion strain variation and the aetiology of \u2018new variant\u2019 CJD","volume":"383","author":"Collinge","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2006.12.006_bib34","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1002\/ana.410390613","article-title":"Molecular basis of phenotypic variability in sporadic Creutzfeldt\u2013Jakob disease","volume":"39","author":"Parchi","year":"1996","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbadis.2006.12.006_bib35","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1099\/vir.0.80375-0","article-title":"PrP glycoforms are associated in a strain-specific ratio in native PrPSc","volume":"86","author":"Khalili-Shirazi","year":"2005","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.bbadis.2006.12.006_bib36","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/2654","article-title":"Eight prion strains have PrP(Sc) molecules with different conformations","volume":"4","author":"Safar","year":"1998","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbadis.2006.12.006_bib37","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/9030","article-title":"Strain-specific prion-protein conformation determined by metal ions","volume":"1","author":"Wadsworth","year":"1999","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbadis.2006.12.006_bib38","doi-asserted-by":"crossref","first-page":"32230","DOI":"10.1074\/jbc.273.48.32230","article-title":"Strain-dependent differences in beta-sheet conformations of abnormal prion protein","volume":"273","author":"Caughey","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2006.12.006_bib39","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0304-3940(99)00659-X","article-title":"Biochemical and conformational variability of human prion strains in sporadic Creutzfeldt\u2013Jakob disease","volume":"274","author":"Aucouturier","year":"1999","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbadis.2006.12.006_bib40","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1099\/vir.0.18996-0","article-title":"Improved conformation-dependent immunoassay: suitability for human prion detection with enhanced sensitivity","volume":"84","author":"Bellon","year":"2003","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.bbadis.2006.12.006_bib41","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.cell.2005.01.034","article-title":"Fibril conformation as the basis of species- and strain-dependent seeding specificity of mammalian prion amyloids","volume":"121","author":"Jones","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2006.12.006_bib42","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1098\/rstb.1994.0036","article-title":"Transmission of bovine spongiform encephalopathy and scrapie to mice: strain variation and the species barrier","volume":"343","author":"Bruce","year":"1994","journal-title":"Philos. Trans. R. Soc. Lond., B Biol. Sci."},{"key":"10.1016\/j.bbadis.2006.12.006_bib43","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1099\/0022-1317-73-8-1891","article-title":"Transmission of bovine spongiform encephalopathy and scrapie to mice","volume":"73","author":"Fraser","year":"1992","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.bbadis.2006.12.006_bib44","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0006-8993(92)90406-Y","article-title":"Successful transmission of Creutzfeldt\u2013Jakob disease from human to mouse verified by prion protein accumulation in mouse brains","volume":"599","author":"Muramoto","year":"1992","journal-title":"Brain Res."},{"key":"10.1016\/j.bbadis.2006.12.006_bib45","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1159\/000077061","article-title":"Prion strains and species barriers","volume":"11","author":"Hill","year":"2004","journal-title":"Contrib. Microbiol."},{"key":"10.1016\/j.bbadis.2006.12.006_bib46","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/S0896-6273(02)00726-2","article-title":"A change in the conformation of prions accompanies the emergence of a new prion strain","volume":"34","author":"Peretz","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.bbadis.2006.12.006_bib47","first-page":"187","article-title":"Species barriers in prion diseases\u2013brief review","author":"Moore","year":"2005","journal-title":"Arch. Virol., Suppl."},{"key":"10.1016\/j.bbadis.2006.12.006_bib48","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S1097-2765(04)00155-8","article-title":"Molecular basis of barriers for interspecies transmissibility of mammalian prions","volume":"14","author":"Vanik","year":"2004","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbadis.2006.12.006_bib49","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/0092-8674(90)90134-Z","article-title":"Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication","volume":"63","author":"Prusiner","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2006.12.006_bib50","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/S0896-6273(02)00736-5","article-title":"A journey through the species barrier","volume":"34","author":"Chen","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.bbadis.2006.12.006_bib51","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/bmb\/66.1.185","article-title":"Bovine spongiform encephalopathy (BSE) and its epidemiology","volume":"66","author":"Smith","year":"2003","journal-title":"Br. Med. Bull."},{"key":"10.1016\/j.bbadis.2006.12.006_bib52","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/S0140-6736(96)01310-4","article-title":"BSE: a decade on\u2013Part I","volume":"349","author":"Collee","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.bbadis.2006.12.006_bib53","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/S0140-6736(96)08496-6","article-title":"BSE: a decade on\u2013Part 2","volume":"349","author":"Collee","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.bbadis.2006.12.006_bib54","unstructured":"A.F. Hill, M. Desbruslais, S. Joiner, K.C. Sidle, I. Gowland, J. Collinge, L.J. Doey, P. Lantos, The same prion strain causes vCJD and BSE. Nature 389 (1997) 448\u201350, 526."},{"key":"10.1016\/j.bbadis.2006.12.006_bib55","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0140-6736(99)05128-4","article-title":"Variant Creutzfeldt\u2013Jakob disease","volume":"354","author":"Collinge","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.bbadis.2006.12.006_bib56","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1292\/jvms.65.341","article-title":"Susceptibility of transgenic mice expressing chimeric sheep, bovine and human PrP genes to sheep scrapie","volume":"65","author":"Gombojav","year":"2003","journal-title":"J. Vet. Med. Sci."},{"key":"10.1016\/j.bbadis.2006.12.006_bib57","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1136\/vr.135.13.296","article-title":"Epidemiological observations on spongiform encephalopathies in captive wild animals in the British Isles","volume":"135","author":"Kirkwood","year":"1994","journal-title":"Vet. Rec."},{"key":"10.1016\/j.bbadis.2006.12.006_bib58","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1136\/vr.131.14.307","article-title":"Feline spongiform encephalopathy: fibril and PrP studies","volume":"131","author":"Pearson","year":"1992","journal-title":"Vet. Rec."},{"key":"10.1016\/j.bbadis.2006.12.006_bib59","doi-asserted-by":"crossref","first-page":"187","DOI":"10.20506\/rst.16.1.1006","article-title":"Bovine spongiform encephalopathy: the causal role of ruminant-derived protein in cattle diets","volume":"16","author":"Taylor","year":"1997","journal-title":"Rev. Sci. Tech."},{"key":"10.1016\/j.bbadis.2006.12.006_bib60","doi-asserted-by":"crossref","first-page":"4046","DOI":"10.1073\/pnas.96.7.4046","article-title":"Natural and experimental oral infection of nonhuman primates by bovine spongiform encephalopathy agents","volume":"96","author":"Bons","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2006.12.006_bib61","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1053\/jcpa.1999.0349","article-title":"The neuropathology of experimental bovine spongiform encephalopathy in the pig","volume":"122","author":"Ryder","year":"2000","journal-title":"J. Comp. Pathol."},{"key":"10.1016\/j.bbadis.2006.12.006_bib62","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1099\/vir.0.18788-0","article-title":"Studies of the transmissibility of the agent of bovine spongiform encephalopathy to pigs","volume":"84","author":"Wells","year":"2003","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.bbadis.2006.12.006_bib63","doi-asserted-by":"crossref","first-page":"5063","DOI":"10.1523\/JNEUROSCI.5400-03.2004","article-title":"Subclinical bovine spongiform encephalopathy infection in transgenic mice expressing porcine prion protein","volume":"24","author":"Castilla","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbadis.2006.12.006_bib64","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1136\/vr.133.14.339","article-title":"Transmission of bovine spongiform encephalopathy to sheep and goats","volume":"133","author":"Foster","year":"1993","journal-title":"Vet. Rec."},{"key":"10.1016\/j.bbadis.2006.12.006_bib65","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s00401-002-0556-2","volume":"104","author":"Stack","year":"2002","journal-title":"Acta Neuropathol. (Berl)"},{"key":"10.1016\/j.bbadis.2006.12.006_bib66","first-page":"638","article-title":"Bovine spongiform encephalopathy: epidemiological studies","volume":"123","author":"Wilesmith","year":"1988","journal-title":"Vet. Rec."},{"key":"10.1016\/j.bbadis.2006.12.006_bib67","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1136\/vr.128.9.199","article-title":"Bovine spongiform encephalopathy: epidemiological studies on the origin","volume":"128","author":"Wilesmith","year":"1991","journal-title":"Vet. Rec."},{"key":"10.1016\/j.bbadis.2006.12.006_bib68","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1093\/bmb\/66.1.199","article-title":"Other animal prion diseases","volume":"66","author":"Sigurdson","year":"2003","journal-title":"Br. Med. Bull."},{"key":"10.1016\/j.bbadis.2006.12.006_bib69","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1354\/vp.42-5-530","article-title":"Chronic wasting disease","volume":"42","author":"Williams","year":"2005","journal-title":"Vet. Pathol."},{"key":"10.1016\/j.bbadis.2006.12.006_bib70","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1001\/archneur.58.10.1673","article-title":"Creutzfeldt\u2013Jakob disease in unusually young patients who consumed venison","volume":"58","author":"Belay","year":"2001","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.bbadis.2006.12.006_bib71","doi-asserted-by":"crossref","first-page":"13794","DOI":"10.1128\/JVI.79.21.13794-13796.2005","article-title":"Interspecies transmission of chronic wasting disease prions to squirrel monkeys (Saimiri sciureus)","volume":"79","author":"Marsh","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.bbadis.2006.12.006_bib72","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1177\/104063870101300121","article-title":"Preliminary findings on the experimental transmission of chronic wasting disease agent of mule deer to cattle","volume":"13","author":"Hamir","year":"2001","journal-title":"J. Vet. Diagn. Invest."},{"key":"10.1016\/j.bbadis.2006.12.006_bib73","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1177\/104063870501700313","article-title":"Experimental transmission of chronic wasting disease agent from mule deer to cattle by the intracerebral route","volume":"17","author":"Hamir","year":"2005","journal-title":"J. Vet. Diagn. Invest."},{"key":"10.1016\/j.bbadis.2006.12.006_bib74","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1136\/vr.153.4.121","article-title":"Experimental inoculation of scrapie and chronic wasting disease agents in raccoons (Procyon lotor)","volume":"153","author":"Hamir","year":"2003","journal-title":"Vet. Rec."},{"key":"10.1016\/j.bbadis.2006.12.006_bib75","doi-asserted-by":"crossref","first-page":"7944","DOI":"10.1523\/JNEUROSCI.2467-05.2005","article-title":"Chronic wasting disease of elk: transmissibility to humans examined by transgenic mouse models","volume":"25","author":"Kong","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbadis.2006.12.006_bib76","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1126\/science.275.5298.402","article-title":"Transmission of the BSE agent to mice in the absence of detectable abnormal prion protein","volume":"275","author":"Lasmezas","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2006.12.006_bib77","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/271778a0","article-title":"Transmission of Creutzfeldt\u2013Jakob disease with scrapie-like syndromes to mice","volume":"271","author":"Manuelidis","year":"1978","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2006.12.006_bib78","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/BF00695613","article-title":"Experimental transmission of human subacute spongiform encephalopathy to small rodents. IV. Positive transmission from a typical case of Gerstmann\u2013Straussler\u2013Scheinker's disease","volume":"64","author":"Tateishi","year":"1984","journal-title":"Acta Neuropathol. (Berl)"},{"key":"10.1016\/j.bbadis.2006.12.006_bib79","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1128\/JVI.59.3.676-683.1986","article-title":"Immunological comparison of scrapie-associated fibrils isolated from animals infected with four different scrapie strains","volume":"59","author":"Kascsak","year":"1986","journal-title":"J. Virol."},{"key":"10.1016\/j.bbadis.2006.12.006_bib80","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/infdis\/164.1.29","article-title":"Scrapie-infected spleens: analysis of infectivity, scrapie-associated fibrils, and protease-resistant proteins","volume":"164","author":"Rubenstein","year":"1991","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.bbadis.2006.12.006_bib81","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1099\/0022-1317-66-8-1715","article-title":"Biochemical differences among scrapie-associated fibrils support the biological diversity of scrapie agents","volume":"66","author":"Kascsak","year":"1985","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.bbadis.2006.12.006_bib82","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1073\/pnas.0409079102","article-title":"Strain-specified characteristics of mouse synthetic prions","volume":"102","author":"Legname","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2006.12.006_bib83","doi-asserted-by":"crossref","first-page":"6243","DOI":"10.1128\/JVI.78.12.6243-6251.2004","article-title":"Molecular analysis of the protease-resistant prion protein in scrapie and bovine spongiform encephalopathy transmitted to ovine transgenic and wild-type mice","volume":"78","author":"Baron","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.bbadis.2006.12.006_bib84","doi-asserted-by":"crossref","first-page":"7991","DOI":"10.1128\/JVI.77.14.7991-7998.2003","article-title":"Subclinical prion disease induced by oral inoculation","volume":"77","author":"Thackray","year":"2003","journal-title":"J. Virol."},{"key":"10.1016\/j.bbadis.2006.12.006_bib85","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/ana.410050616","article-title":"Transmission of chronic spongiform encephalopathy with kuru plaques from humans to small rodents","volume":"5","author":"Tateishi","year":"1979","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbadis.2006.12.006_bib86","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0140-6736(90)91518-F","article-title":"Prion dementia without characteristic pathology","volume":"336","author":"Collinge","year":"1990","journal-title":"Lancet"},{"key":"10.1016\/j.bbadis.2006.12.006_bib87","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1212\/WNL.42.3.669","article-title":"Fatal familial insomnia: a second kindred with mutation of prion protein gene at codon 178","volume":"42","author":"Medori","year":"1992","journal-title":"Neurology"},{"key":"10.1016\/j.bbadis.2006.12.006_bib88","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s00335-004-3041-5","article-title":"Identification and characterization of a novel mouse prion gene allele","volume":"15","author":"Lloyd","year":"2004","journal-title":"Mamm. Genome"},{"key":"10.1016\/j.bbadis.2006.12.006_bib89","doi-asserted-by":"crossref","first-page":"7859","DOI":"10.1128\/JVI.68.12.7859-7868.1994","article-title":"Distinct PrP properties suggest the molecular basis of strain variation in transmissible mink encephalopathy","volume":"68","author":"Bessen","year":"1994","journal-title":"J. Virol."},{"key":"10.1016\/j.bbadis.2006.12.006_bib90","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/375698a0","article-title":"Non-genetic propagation of strain-specific properties of scrapie prion protein","volume":"375","author":"Bessen","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2006.12.006_bib91","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/BF00266934","article-title":"Host-genotype and agent effects in scrapie incubation: change in allelic interaction with different strains of agent","volume":"112","author":"Dickinson","year":"1971","journal-title":"Mol. Gen. Genet."},{"key":"10.1016\/j.bbadis.2006.12.006_bib92","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1099\/0022-1317-68-2-401","article-title":"Genetic control of scrapie: incubation period and plaque formation in I mice","volume":"68","author":"Carp","year":"1987","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.bbadis.2006.12.006_bib93","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/0092-8674(86)90875-5","article-title":"Linkage of prion protein and scrapie incubation time genes","volume":"46","author":"Carlson","year":"1986","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2006.12.006_bib94","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1099\/0022-1317-73-10-2751","article-title":"Are Sinc and the PrP gene congruent? Evidence from PrP gene analysis in Sinc congenic mice","volume":"73","author":"Hunter","year":"1992","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.bbadis.2006.12.006_bib95","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1136\/vr.153.7.202","article-title":"Cases of scrapie with unusual features in Norway and designation of a new type, Nor98","volume":"153","author":"Benestad","year":"2003","journal-title":"Vet. Rec."},{"key":"10.1016\/j.bbadis.2006.12.006_bib96","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1136\/vr.148.6.165","article-title":"Clinical signs, histopathology and genetics of experimental transmission of BSE and natural scrapie to sheep and goats","volume":"148","author":"Foster","year":"2001","journal-title":"Vet. Rec."},{"key":"10.1016\/j.bbadis.2006.12.006_bib97","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1099\/0022-1317-80-4-1073","article-title":"Prion protein gene polymorphisms in sheep with natural scrapie and healthy controls in Norway","volume":"80","author":"Tranulis","year":"1999","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.bbadis.2006.12.006_bib98","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/0140-6736(91)93128-V","article-title":"Genetic predisposition to iatrogenic Creutzfeldt\u2013Jakob disease","volume":"337","author":"Collinge","year":"1991","journal-title":"Lancet"},{"key":"10.1016\/j.bbadis.2006.12.006_bib99","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/352340a0","article-title":"Homozygous prion protein genotype predisposes to sporadic Creutzfeldt\u2013Jakob disease","volume":"352","author":"Palmer","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2006.12.006_bib100","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1086\/317935","article-title":"Increased susceptibility to Kuru of carriers of the PRNP 129 methionine\/methionine genotype","volume":"183","author":"Lee","year":"2001","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.bbadis.2006.12.006_bib101","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1126\/science.1083320","article-title":"Balancing selection at the prion protein gene consistent with prehistoric kurulike epidemics","volume":"300","author":"Mead","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2006.12.006_bib102","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1212\/WNL.54.8.1641","article-title":"Neuropathologic variants of sporadic Creutzfeldt\u2013Jakob disease and codon 129 of PrP gene","volume":"54","author":"Hauw","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.bbadis.2006.12.006_bib103","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/1531-8249(199908)46:2<224::AID-ANA12>3.0.CO;2-W","article-title":"Classification of sporadic Creutzfeldt\u2013Jakob disease based on molecular and phenotypic analysis of 300 subjects","volume":"46","author":"Parchi","year":"1999","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbadis.2006.12.006_bib104","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1126\/science.1439789","article-title":"Fatal familial insomnia and familial Creutzfeldt\u2013Jakob disease: disease phenotype determined by a DNA polymorphism","volume":"258","author":"Goldfarb","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2006.12.006_bib105","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1093\/brain\/awg125","article-title":"Molecular classification of sporadic Creutzfeldt\u2013Jakob disease","volume":"126","author":"Hill","year":"2003","journal-title":"Brain"},{"key":"10.1016\/j.bbadis.2006.12.006_bib106","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/S0140-6736(03)13867-6","article-title":"Distribution of codon 129 genotype in human growth hormone-treated CJD patients in France and the UK","volume":"362","author":"Brandel","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.bbadis.2006.12.006_bib107","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S1474-4422(06)70413-6","article-title":"Predicting susceptibility and incubation time of human-to-human transmission of vCJD","volume":"5","author":"Bishop","year":"2006","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.bbadis.2006.12.006_bib108","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1111\/j.1471-4159.2006.03909.x","article-title":"Prion diseases of humans and farm animals: epidemiology, genetics, and pathogenesis","volume":"97","author":"Aguzzi","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbadis.2006.12.006_bib109","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S0140-6736(05)64378-4","article-title":"Prion protein gene analysis in new variant cases of Creutzfeldt\u2013Jakob disease","volume":"348","author":"Collinge","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.bbadis.2006.12.006_bib110","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1001\/archneur.62.4.545","article-title":"Human prion diseases: molecular and clinical aspects","volume":"62","author":"Glatzel","year":"2005","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.bbadis.2006.12.006_bib111","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1093\/bmb\/66.1.213","article-title":"Sporadic and familial CJD: classification and characterisation","volume":"66","author":"Gambetti","year":"2003","journal-title":"Br. Med. Bull."},{"key":"10.1016\/j.bbadis.2006.12.006_bib112","doi-asserted-by":"crossref","first-page":"10168","DOI":"10.1073\/pnas.97.18.10168","article-title":"Genetic influence on the structural variations of the abnormal prion protein","volume":"97","author":"Parchi","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.bbadis.2006.12.006_bib113","doi-asserted-by":"crossref","first-page":"e14","DOI":"10.1371\/journal.pmed.0030014","article-title":"Analysis of prion strains by PrP(Sc) profiling in sporadic Creutzfeldt\u2013Jakob disease","volume":"3","author":"Schoch","year":"2005","journal-title":"PLoS Med."},{"key":"10.1016\/j.bbadis.2006.12.006_bib114","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/1531-8249(200008)48:2<269::AID-ANA24>3.0.CO;2-V","article-title":"Polymorphism at codon 129 of PRNP affects the phenotypic expression of Creutzfeldt\u2013Jakob disease linked to E200K mutation","volume":"48","author":"Puoti","year":"2000","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbadis.2006.12.006_bib115","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0003-3995(03)00017-0","article-title":"Gerstmann\u2013Straussler\u2013Scheinker disease with P102L-V129 mutation: a case with psychiatric manifestations at onset","volume":"46","author":"Bianca","year":"2003","journal-title":"Ann. Genet."},{"key":"10.1016\/j.bbadis.2006.12.006_bib116","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/j.1750-3639.1998.tb00172.x","article-title":"Clinical features of fatal familial insomnia: phenotypic variability in relation to a polymorphism at codon 129 of the prion protein gene","volume":"8","author":"Montagna","year":"1998","journal-title":"Brain Pathol."},{"key":"10.1016\/j.bbadis.2006.12.006_bib117","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/BF02780659","article-title":"A novel mechanism of phenotypic heterogeneity demonstrated by the effect of a polymorphism on a pathogenic mutation in the PRNP (prion protein gene)","volume":"8","author":"Petersen","year":"1994","journal-title":"Mol. Neurobiol."},{"issue":"Suppl. 1","key":"10.1016\/j.bbadis.2006.12.006_bib118","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1046\/j.1365-2869.1999.00005.x","article-title":"Fatal familial insomnia: clinical features and molecular genetics","volume":"8","author":"Cortelli","year":"1999","journal-title":"J. Sleep Res."},{"key":"10.1016\/j.bbadis.2006.12.006_bib119","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1002\/1531-8249(199906)45:6<812::AID-ANA20>3.0.CO;2-2","article-title":"A novel phenotype in familial Creutzfeldt\u2013Jakob disease: prion protein gene E200K mutation coupled with valine at codon 129 and type 2 protease-resistant prion protein","volume":"45","author":"Hainfellner","year":"1999","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbadis.2006.12.006_bib120","doi-asserted-by":"crossref","first-page":"3258","DOI":"10.1021\/bi982714g","article-title":"Influence of amino acid substitutions related to inherited human prion diseases on the thermodynamic stability of the cellular prion protein","volume":"38","author":"Liemann","year":"1999","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbadis.2006.12.006_bib121","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1073\/pnas.97.1.145","article-title":"NMR solution structure of the human prion protein","volume":"97","author":"Zahn","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2006.12.006_bib122","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1006\/bbrc.2000.2355","article-title":"Copper has differential effect on prion protein with polymorphism of position 129","volume":"269","author":"Wong","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbadis.2006.12.006_bib123","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0014-5793(01)03147-7","article-title":"Biochemical and structural studies of the prion protein polymorphism","volume":"509","author":"Petchanikow","year":"2001","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbadis.2006.12.006_bib124","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1074\/jbc.M307844200","article-title":"Strain-specific kinetics of prion protein formation in vitro and in vivo","volume":"279","author":"Mulcahy","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2006.12.006_bib125","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1212\/WNL.53.9.2173","article-title":"Sporadic Creutzfeldt\u2013Jakob disease: co-occurrence of different types of PrP(Sc) in the same brain","volume":"53","author":"Puoti","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.bbadis.2006.12.006_bib126","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1093\/brain\/awh249","article-title":"Predictors of survival in sporadic Creutzfeldt\u2013Jakob disease and other human transmissible spongiform encephalopathies","volume":"127","author":"Pocchiari","year":"2004","journal-title":"Brain"},{"key":"10.1016\/j.bbadis.2006.12.006_bib127","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/ana.410160305","article-title":"Creutzfeldt\u2013Jakob disease of long duration: clinicopathological characteristics, transmissibility, and differential diagnosis","volume":"16","author":"Brown","year":"1984","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbadis.2006.12.006_bib128","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/256732a0","article-title":"Scrapie incubation time can exceed natural lifespan","volume":"256","author":"Dickinson","year":"1975","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2006.12.006_bib129","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1159\/000149588","article-title":"Competition between strains of scrapie depends on the blocking agent being infectious","volume":"23","author":"Kimberlin","year":"1985","journal-title":"Intervirology"},{"key":"10.1016\/j.bbadis.2006.12.006_bib130","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1099\/vir.0.19394-0","article-title":"Delay in onset of prion disease for the HY strain of transmissible mink encephalopathy as a result of prior peripheral inoculation with the replication-deficient DY strain","volume":"85","author":"Bartz","year":"2004","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.bbadis.2006.12.006_bib131","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev.med.56.062404.172936","article-title":"Approaches to therapy of prion diseases","volume":"56","author":"Weissmann","year":"2005","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.bbadis.2006.12.006_bib132","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/S0140-6736(99)11419-3","article-title":"Reversion of prion protein conformational changes by synthetic beta-sheet breaker peptides","volume":"355","author":"Soto","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.bbadis.2006.12.006_bib133","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/35089090","article-title":"Antibodies inhibit prion propagation and clear cell cultures of prion infectivity","volume":"412","author":"Peretz","year":"2001","journal-title":"Nature"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443906002729?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443906002729?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,19]],"date-time":"2020-04-19T10:21:10Z","timestamp":1587291670000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443906002729"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":133,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["S0925443906002729"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2006.12.006","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2007,6]]}}}