{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T20:39:21Z","timestamp":1790973561490,"version":"4.1.0"},"reference-count":322,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,11,20]],"date-time":"2014-11-20T00:00:00Z","timestamp":1416441600000},"content-version":"vor","delay-in-days":1784,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"National Health and Medical Research Council of Australia"},{"DOI":"10.13039\/100012599","name":"Bethlehem Griffiths Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012599","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008714","name":"Motor Neurone Disease Research Institute of Australia","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008714","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Henry H Roth Charitable Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1016\/j.bbadis.2009.09.004","type":"journal-article","created":{"date-parts":[[2009,9,13]],"date-time":"2009-09-13T08:17:58Z","timestamp":1252829878000},"page":"167-185","source":"Crossref","is-referenced-by-count":95,"title":["Multifaceted deaths orchestrated by mitochondria in neurones"],"prefix":"10.1016","volume":"1802","author":[{"given":"Phillip","family":"Nagley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin C.","family":"Higgins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie D.","family":"Atkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip M.","family":"Beart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2009.09.004_bib1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0166-2236(99)01401-0","article-title":"Pathobiology of ischaemic stroke: an integrated view","volume":"22","author":"Dirnagl","year":"1999","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.bbadis.2009.09.004_bib2","doi-asserted-by":"crossref","first-page":"79","DOI":"10.2174\/156652406775574550","article-title":"ER stress and UPR in familial amyotrophic lateral sclerosis","volume":"6","author":"Turner","year":"2006","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.bbadis.2009.09.004_bib3","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1111\/j.1471-4159.2004.02572.x","article-title":"Mitochondrial mechanisms of neural cell apoptosis","volume":"90","author":"Polster","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbadis.2009.09.004_bib4","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1152\/physrev.00013.2006","article-title":"Mitochondrial membrane permeabilization in cell death","volume":"87","author":"Kroemer","year":"2007","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbadis.2009.09.004_bib5","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/iub.44","article-title":"The mitochondrial gateway to cell death","volume":"60","author":"Smith","year":"2008","journal-title":"IUBMB Life"},{"key":"10.1016\/j.bbadis.2009.09.004_bib6","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/BF00174615","article-title":"Developmental cell death: morphological diversity and multiple mechanisms","volume":"181","author":"Clarke","year":"1990","journal-title":"Anat. Embryol. (Berl)"},{"key":"10.1016\/j.bbadis.2009.09.004_bib7","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.mam.2006.08.009","article-title":"Neuronal macroautophagy: from development to degeneration","volume":"27","author":"Boland","year":"2006","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.bbadis.2009.09.004_bib8","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/nature06639","article-title":"Autophagy fights disease through cellular self-digestion","volume":"451","author":"Mizushima","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2009.09.004_bib9","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1196\/annals.1427.002","article-title":"Oxidative stress and energy crises in neuronal dysfunction","volume":"1147","author":"Nicholls","year":"2008","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.bbadis.2009.09.004_bib10","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1742-4658.2005.05103.x","article-title":"Calcium, mitochondria and oxidative stress in neuronal pathology. Novel aspects of an enduring theme","volume":"273","author":"Chinopoulos","year":"2006","journal-title":"FEBS J."},{"key":"10.1016\/j.bbadis.2009.09.004_bib11","doi-asserted-by":"crossref","first-page":"20796","DOI":"10.1074\/jbc.M109.025353","article-title":"Calcium elevation in mitochondria is the main Ca2+ requirement for mitochondrial permeability transition pore (mPTP) opening","volume":"284","author":"Baumgartner","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2009.09.004_bib12","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/glia.20207","article-title":"Astrocyte activation and reactive gliosis","volume":"50","author":"Pekny","year":"2005","journal-title":"Glia"},{"key":"10.1016\/j.bbadis.2009.09.004_bib13","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/ncpneuro0355","article-title":"Mechanisms of Disease: astrocytes in neurodegenerative disease","volume":"2","author":"Maragakis","year":"2006","journal-title":"Nat. Clin. Pract. Neurol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib14","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1038\/nn1997","article-title":"Microglia: active sensor and versatile effector cells in the normal and pathologic brain","volume":"10","author":"Hanisch","year":"2007","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbadis.2009.09.004_bib15","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/cdd.2008.150","article-title":"Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009","volume":"16","author":"Kroemer","year":"2009","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbadis.2009.09.004_bib16","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/S0028-3908(98)00123-3","article-title":"Micromolar L-glutamate induces extensive apoptosis in an apoptotic-necrotic continuum of insult-dependent, excitotoxic injury in cultured cortical neurones","volume":"37","author":"Cheung","year":"1998","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbadis.2009.09.004_bib17","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1038\/sj.onc.1207559","article-title":"Regulation of the apoptosis-necrosis switch","volume":"23","author":"Nicotera","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.bbadis.2009.09.004_bib18","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.4161\/cc.6.21.4842","article-title":"AIF-mediated programmed necrosis: a highly regulated way to die","volume":"6","author":"Boujrad","year":"2007","journal-title":"Cell Cycle"},{"key":"10.1016\/j.bbadis.2009.09.004_bib19","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1007\/s10495-007-0754-4","article-title":"Pathological apoptosis in the developing brain","volume":"12","author":"Blomgren","year":"2007","journal-title":"Apoptosis"},{"key":"10.1016\/j.bbadis.2009.09.004_bib20","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1007\/s11064-008-9649-1","article-title":"Hypoxia ischemia-mediated cell death in neonatal rat brain","volume":"33","author":"Gill","year":"2008","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.bbadis.2009.09.004_bib21","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nchembio711","article-title":"Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury","volume":"1","author":"Degterev","year":"2005","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib22","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.expneurol.2009.03.020","article-title":"Poly(ADP-ribose) signals to mitochondrial AIF: A key event in parthanatos","volume":"218","author":"Wang","year":"2009","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib23","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nrm2308","article-title":"The BCL-2 protein family: opposing activities that mediate cell death","volume":"9","author":"Youle","year":"2008","journal-title":"Nat. Rev., Mol. Cell Biol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib24","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/35037710","article-title":"The biochemistry of apoptosis","volume":"407","author":"Hengartner","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2009.09.004_bib25","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1111\/j.1471-4159.2007.04937.x","article-title":"Hierarchical recruitment by AMPA but not staurosporine of pro-apoptotic mitochondrial signaling in cultured cortical neurons: evidence for caspase-dependent\/independent cross-talk","volume":"103","author":"Beart","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbadis.2009.09.004_bib26","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/s00018-008-8490-7","article-title":"Differential insult-dependent recruitment of the intrinsic mitochondrial pathway during neuronal programmed cell death","volume":"66","author":"Diwakarla","year":"2009","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bbadis.2009.09.004_bib27","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1007\/s00018-009-0079-2","article-title":"Oxidative stress triggers neuronal caspase-independent death: Endonuclease G involvement in Programmed Cell Death-Type III","volume":"66","author":"Higgins","year":"2009","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bbadis.2009.09.004_bib28","doi-asserted-by":"crossref","first-page":"16175","DOI":"10.1074\/jbc.M414552200","article-title":"Calpain mediates excitotoxic DNA fragmentation via mitochondrial pathways in adult brains: evidence from calpastatin mutant mice","volume":"280","author":"Takano","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2009.09.004_bib29","doi-asserted-by":"crossref","first-page":"PE31","DOI":"10.1126\/stke.2003.193.pe31","article-title":"AIF: a multifunctional cog in the life and death machine","volume":"2003","author":"Hansen","year":"2003","journal-title":"Sci. STKE"},{"key":"10.1016\/j.bbadis.2009.09.004_bib30","doi-asserted-by":"crossref","first-page":"6447","DOI":"10.1074\/jbc.M413269200","article-title":"Calpain I induces cleavage and release of apoptosis-inducing factor from isolated mitochondria","volume":"280","author":"Polster","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2009.09.004_bib31","doi-asserted-by":"crossref","first-page":"9065","DOI":"10.1074\/jbc.M413030200","article-title":"Neurons exclusively express N-Bak, a BH3 domain-only Bak isoform that promotes neuronal apoptosis","volume":"280","author":"Uo","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2009.09.004_bib32","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.bbrc.2005.03.149","article-title":"p53 in neuronal apoptosis","volume":"331","author":"Culmsee","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbadis.2009.09.004_bib33","doi-asserted-by":"crossref","first-page":"12989","DOI":"10.1523\/JNEUROSCI.3400-07.2007","article-title":"Puma is a dominant regulator of oxidative stress induced Bax activation and neuronal apoptosis","volume":"27","author":"Steckley","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbadis.2009.09.004_bib34","doi-asserted-by":"crossref","first-page":"12198","DOI":"10.1523\/JNEUROSCI.3222-05.2007","article-title":"Apoptotic actions of p53 require transcriptional activation of PUMA and do not involve a direct mitochondrial\/cytoplasmic site of action in postnatal cortical neurons","volume":"27","author":"Uo","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbadis.2009.09.004_bib35","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1111\/j.1471-4159.2005.03676.x","article-title":"The BH3-only protein Puma is both necessary and sufficient for neuronal apoptosis induced by DNA damage in sympathetic neurons","volume":"96","author":"Wyttenbach","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbadis.2009.09.004_bib36","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1161\/STROKEAHA.108.524447","article-title":"Potential role of PUMA in delayed death of hippocampal CA1 neurons after transient global cerebral ischemia","volume":"40","author":"Niizuma","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.bbadis.2009.09.004_bib37","doi-asserted-by":"crossref","first-page":"20606","DOI":"10.1073\/pnas.0707906105","article-title":"Deletion of the BH3-only protein puma protects motoneurons from ER stress-induced apoptosis and delays motoneuron loss in ALS mice","volume":"104","author":"Kieran","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2009.09.004_bib38","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1111\/j.1471-4159.2007.05187.x","article-title":"NMDA receptor-mediated excitotoxic neuronal apoptosis in vitro and in vivo occurs in an ER stress and PUMA independent manner","volume":"105","author":"Concannon","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbadis.2009.09.004_bib39","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1083\/jcb.144.5.891","article-title":"Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis","volume":"144","author":"Desagher","year":"1999","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib40","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2121-8-7","article-title":"Full length Bid is sufficient to induce apoptosis of cultured rat hippocampal neurons","volume":"8","author":"Konig","year":"2007","journal-title":"BMC Cell Biol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib41","doi-asserted-by":"crossref","first-page":"16368","DOI":"10.1073\/pnas.0806222105","article-title":"The PIDDosome mediates delayed death of hippocampal CA1 neurons after transient global cerebral ischemia in rats","volume":"105","author":"Niizuma","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2009.09.004_bib42","doi-asserted-by":"crossref","first-page":"15318","DOI":"10.1073\/pnas.261323298","article-title":"BID mediates neuronal cell death after oxygen\/ glucose deprivation and focal cerebral ischemia","volume":"98","author":"Plesnila","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2009.09.004_bib43","doi-asserted-by":"crossref","first-page":"42074","DOI":"10.1074\/jbc.M204991200","article-title":"Bid-mediated mitochondrial pathway is critical to ischemic neuronal apoptosis and focal cerebral ischemia","volume":"277","author":"Yin","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2009.09.004_bib44","doi-asserted-by":"crossref","first-page":"10262","DOI":"10.1523\/JNEUROSCI.2818-05.2005","article-title":"Apoptosis-inducing factor triggered by poly(ADP-ribose) polymerase and Bid mediates neuronal cell death after oxygen-glucose deprivation and focal cerebral ischemia","volume":"25","author":"Culmsee","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbadis.2009.09.004_bib45","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1038\/cdd.2008.78","article-title":"Bid-induced release of AIF from mitochondria causes immediate neuronal cell death","volume":"15","author":"Landshamer","year":"2008","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbadis.2009.09.004_bib46","doi-asserted-by":"crossref","first-page":"5837","DOI":"10.1074\/jbc.M511562200","article-title":"Real time single cell analysis of Bid cleavage and Bid translocation during caspase-dependent and neuronal caspase-independent apoptosis","volume":"281","author":"Ward","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2009.09.004_bib47","doi-asserted-by":"crossref","first-page":"9519","DOI":"10.1523\/JNEUROSCI.21-24-09519.2001","article-title":"Caspase-9 activation results in downstream caspase-8 activation and bid cleavage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease","volume":"21","author":"Viswanath","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbadis.2009.09.004_bib48","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1083\/jcb.200202130","article-title":"Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death","volume":"158","author":"Cregan","year":"2002","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib49","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/sj.cdd.4402053","article-title":"Apoptosis-inducing factor is a major contributor to neuronal loss induced by neonatal cerebral hypoxia-ischemia","volume":"14","author":"Zhu","year":"2007","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbadis.2009.09.004_bib50","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1084\/jem.20070193","article-title":"Cyclophilin A participates in the nuclear translocation of apoptosis-inducing factor in neurons after cerebral hypoxia-ischemia","volume":"204","author":"Zhu","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbadis.2009.09.004_bib51","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.brainres.2006.04.131","article-title":"Inhibition of caspase-8 attenuates neuronal death induced by limbic seizures in a cytochrome c-dependent and Smac\/DIABLO-independent way","volume":"1098","author":"Li","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.bbadis.2009.09.004_bib52","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1007\/s11064-008-9637-5","article-title":"Role of inhibitor of apoptosis proteins and Smac\/DIABLO in staurosporine-induced cerebellar granule neurons death","volume":"33","author":"Maycotte","year":"2008","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.bbadis.2009.09.004_bib53","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.bbrc.2007.07.118","article-title":"Transgenic mice with neuron-specific overexpression of HtrA2\/Omi suggest a neuroprotective role for HtrA2\/Omi","volume":"362","author":"Liu","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbadis.2009.09.004_bib54","doi-asserted-by":"crossref","first-page":"9848","DOI":"10.1128\/MCB.24.22.9848-9862.2004","article-title":"Neuroprotective role of the Reaper-related serine protease HtrA2\/Omi revealed by targeted deletion in mice","volume":"24","author":"Martins","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib55","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1750-1326-4-16","article-title":"All-you-can-eat: autophagy in neurodegeneration and neuroprotection","volume":"4","author":"Jaeger","year":"2009","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.bbadis.2009.09.004_bib56","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.bbadis.2008.10.016","article-title":"Autophagy: principles and significance in health and disease","volume":"1792","author":"Todde","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2009.09.004_bib57","doi-asserted-by":"crossref","first-page":"5720","DOI":"10.1093\/emboj\/19.21.5720","article-title":"LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing","volume":"19","author":"Kabeya","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/j.bbadis.2009.09.004_bib58","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.mam.2006.08.006","article-title":"Mitochondrial damage and intralysosomal degradation in cellular aging","volume":"27","author":"Terman","year":"2006","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.bbadis.2009.09.004_bib59","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/441819a","article-title":"Neurodegeneration: good riddance to bad rubbish","volume":"441","author":"Klionsky","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2009.09.004_bib60","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1038\/nrm2529","article-title":"Autophagic cell death: the story of a misnomer","volume":"9","author":"Kroemer","year":"2008","journal-title":"Nat. Rev., Mol. Cell Biol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib61","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1126\/science.1096645","article-title":"Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8","volume":"304","author":"Yu","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2009.09.004_bib62","doi-asserted-by":"crossref","first-page":"20722","DOI":"10.1074\/jbc.M413934200","article-title":"Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death","volume":"280","author":"Pyo","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2009.09.004_bib63","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1006\/mcne.1999.0780","article-title":"Autophagy is activated by apoptotic signalling in sympathetic neurons: an alternative mechanism of death execution","volume":"14","author":"Xue","year":"1999","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.bbadis.2009.09.004_bib64","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/jnr.10663","article-title":"Dopamine induces autophagic cell death and alpha-synuclein increase in human neuroblastoma SH-SY5Y cells","volume":"73","author":"Gomez-Santos","year":"2003","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bbadis.2009.09.004_bib65","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.nbd.2008.09.009","article-title":"Spinal cord injury induces upregulation of Beclin 1 and promotes autophagic cell death","volume":"33","author":"Kanno","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbadis.2009.09.004_bib66","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1111\/j.1471-4159.2004.02956.x","article-title":"Role of the autophagic-lysosomal system on low potassium-induced apoptosis in cultured cerebellar granule cells","volume":"92","author":"Canu","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbadis.2009.09.004_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2009.03.002","article-title":"Mitophagy","author":"Tolkovsky","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2009.09.004_bib68","doi-asserted-by":"crossref","first-page":"3900","DOI":"10.1038\/sj.emboj.7601253","article-title":"Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons","volume":"25","author":"Barsoum","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.bbadis.2009.09.004_bib69","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1083\/jcb.200809125","article-title":"Parkin is recruited selectively to impaired mitochondria and promotes their autophagy","volume":"183","author":"Narendra","year":"2008","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib70","doi-asserted-by":"crossref","first-page":"75","DOI":"10.2353\/ajpath.2007.060524","article-title":"Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death","volume":"170","author":"Zhu","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib71","doi-asserted-by":"crossref","first-page":"13123","DOI":"10.1074\/jbc.M700492200","article-title":"Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein","volume":"282","author":"Oberstein","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2009.09.004_bib72","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.cell.2005.07.002","article-title":"Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy","volume":"122","author":"Pattingre","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2009.09.004_bib73","doi-asserted-by":"crossref","first-page":"374","DOI":"10.4161\/auto.4237","article-title":"BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2\/Bcl-X(L)","volume":"3","author":"Maiuri","year":"2007","journal-title":"Autophagy"},{"key":"10.1016\/j.bbadis.2009.09.004_bib74","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1038\/onc.2009.60","article-title":"Bcl-2 complexed with Beclin-1 maintains full anti-apoptotic function","volume":"28","author":"Ciechomska","year":"2009","journal-title":"Oncogene"},{"key":"10.1016\/j.bbadis.2009.09.004_bib75","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1038\/sj.emboj.7601689","article-title":"Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1","volume":"26","author":"Maiuri","year":"2007","journal-title":"EMBO J."},{"key":"10.1016\/j.bbadis.2009.09.004_bib76","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1083\/jcb.152.4.657","article-title":"Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells","volume":"152","author":"Mizushima","year":"2001","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib77","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1038\/ncb1482","article-title":"Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis","volume":"8","author":"Yousefi","year":"2006","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib78","doi-asserted-by":"crossref","first-page":"195","DOI":"10.4161\/auto.5278","article-title":"Hypoxia induces autophagic cell death in apoptosis-competent cells through a mechanism involving BNIP3","volume":"4","author":"Azad","year":"2008","journal-title":"Autophagy"},{"key":"10.1016\/j.bbadis.2009.09.004_bib79","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1038\/sj.onc.1210783","article-title":"BH3-only protein BIK induces caspase-independent cell death with autophagic features in Bcl-2 null cells","volume":"27","author":"Rashmi","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.bbadis.2009.09.004_bib80","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.tibs.2006.11.001","article-title":"Cell death by necrosis: towards a molecular definition","volume":"32","author":"Golstein","year":"2007","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.bbadis.2009.09.004_bib81","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nchembio.83","article-title":"Identification of RIP1 kinase as a specific cellular target of necrostatins","volume":"4","author":"Degterev","year":"2008","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib82","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/nature03434","article-title":"Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death","volume":"434","author":"Baines","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2009.09.004_bib83","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/nature03317","article-title":"Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death","volume":"434","author":"Nakagawa","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2009.09.004_bib84","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1042\/BJ20040669","article-title":"Cyclophilin-D promotes the mitochondrial permeability transition but has opposite effects on apoptosis and necrosis","volume":"383","author":"Li","year":"2004","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbadis.2009.09.004_bib85","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1128\/MCB.26.6.2215-2225.2006","article-title":"Inhibition of ADP\/ATP exchange in receptor-interacting protein-mediated necrosis","volume":"26","author":"Temkin","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib86","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.cell.2008.12.004","article-title":"Necroptosis: a specialized pathway of programmed necrosis","volume":"135","author":"Galluzzi","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2009.09.004_bib87","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1111\/j.1471-4159.2007.04884.x","article-title":"Necrostatin-1 protects against glutamate-induced glutathione depletion and caspase-independent cell death in HT-22 cells","volume":"103","author":"Xu","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbadis.2009.09.004_bib88","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.neulet.2008.08.037","article-title":"Necroptosis contributes to the NMDA-induced excitotoxicity in rat's cultured cortical neurons","volume":"447","author":"Li","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbadis.2009.09.004_bib89","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.cell.2008.10.044","article-title":"Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway","volume":"135","author":"Hitomi","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2009.09.004_bib90","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1038\/sj.onc.1209852","article-title":"Upregulation of two BH3-only proteins, Bmf and Bim, during TGF beta-induced apoptosis","volume":"26","author":"Ramjaun","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.bbadis.2009.09.004_bib91","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1007\/s10495-006-8266-1","article-title":"Bmf contributes to histone deacetylase inhibitor-mediated enhancing effects on apoptosis after ionizing radiation","volume":"11","author":"Zhang","year":"2006","journal-title":"Apoptosis"},{"key":"10.1016\/j.bbadis.2009.09.004_bib92","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1196\/annals.1369.034","article-title":"Calpain activation in apoptosis of motoneurons in cell culture models of experimental parkinsonism","volume":"1074","author":"Samantaray","year":"2006","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.bbadis.2009.09.004_bib93","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1007\/s11064-007-9433-7","article-title":"Direct evidence for calpain involvement in apoptotic death of neurons in spinal cord injury in rats and neuroprotection with calpain inhibitor","volume":"32","author":"Sribnick","year":"2007","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.bbadis.2009.09.004_bib94","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1097\/01.wnr.0000220127.01597.04","article-title":"Calpain inhibitors delay injury-induced apoptosis in adult mouse spinal cord motor neurons","volume":"17","author":"Momeni","year":"2006","journal-title":"NeuroReport"},{"issue":"Suppl 1","key":"10.1016\/j.bbadis.2009.09.004_bib95","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/j.1471-4159.2009.05937.x","article-title":"GABAergic striatal neurons exhibit caspase-independent, mitochondrially mediated programmed cell death","volume":"109","author":"Diwakarla","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbadis.2009.09.004_bib96","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1002\/hipo.10127","article-title":"Sustained calpain activation associated with lysosomal rupture executes necrosis of the postischemic CA1 neurons in primates","volume":"13","author":"Yamashima","year":"2003","journal-title":"Hippocampus"},{"key":"10.1016\/j.bbadis.2009.09.004_bib97","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1093\/jnen\/62.6.633","article-title":"Calpain facilitates the neuron death induced by 3-nitropropionic acid and contributes to the necrotic morphology","volume":"62","author":"Pang","year":"2003","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib98","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1146\/annurev.neuro.24.1.677","article-title":"Neurotrophins: roles in neuronal development and function","volume":"24","author":"Huang","year":"2001","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.bbadis.2009.09.004_bib99","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/sj.cdd.4400424","article-title":"Cleavage of the calpain inhibitor, calpastatin, during apoptosis","volume":"5","author":"Porn-Ares","year":"1998","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbadis.2009.09.004_bib100","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1006\/abbi.1998.0748","article-title":"Caspase-mediated fragmentation of calpain inhibitor protein calpastatin during apoptosis","volume":"356","author":"Wang","year":"1998","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bbadis.2009.09.004_bib101","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1046\/j.1471-4159.2003.01794.x","article-title":"Cyclosporin A prevents calpain activation despite increased intracellular calcium concentrations, as well as translocation of apoptosis-inducing factor, cytochrome c and caspase-3 activation in neurons exposed to transient hypoglycemia","volume":"85","author":"Ferrand-Drake","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbadis.2009.09.004_bib102","doi-asserted-by":"crossref","first-page":"4061","DOI":"10.1038\/sj.emboj.7601276","article-title":"Dissociating the dual roles of apoptosis-inducing factor in maintaining mitochondrial structure and apoptosis","volume":"25","author":"Cheung","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.bbadis.2009.09.004_bib103","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.brainres.2008.09.075","article-title":"Multiple apoptogenic proteins are involved in the nuclear translocation of Apoptosis Inducing Factor during transient focal cerebral ischemia in rat","volume":"1246","author":"Chaitanya","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.bbadis.2009.09.004_bib104","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.neulet.2006.07.044","article-title":"AIF translocates to the nucleus in the spinal motor neurons in a mouse model of ALS","volume":"406","author":"Oh","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbadis.2009.09.004_bib105","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.expneurol.2009.04.032","article-title":"Calcium dysregulation induces apoptosis-inducing factor release: Cross-talk between PARP-1- and calpain- signaling pathways","volume":"218","author":"Vosler","year":"2009","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib106","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1002\/jmv.21502","article-title":"Enterovirus 71-induced autophagy detected in vitro and in vivo promotes viral replication","volume":"81","author":"Huang","year":"2009","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib107","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1038\/sj.cdd.4400944","article-title":"Endonuclease G: a mitochondrial protein released in apoptosis and involved in caspase-independent DNA degradation","volume":"8","author":"van Loo","year":"2001","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbadis.2009.09.004_bib108","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1038\/sj.cdd.4401787","article-title":"EndoG is dispensable in embryogenesis and apoptosis","volume":"13","author":"David","year":"2006","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbadis.2009.09.004_bib109","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/35083620","article-title":"Endonuclease G is an apoptotic DNase when released from mitochondria","volume":"412","author":"Li","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2009.09.004_bib110","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s00221-008-1452-3","article-title":"Endonuclease G expression in thalamic reticular nucleus after global cerebral ischemia","volume":"190","author":"Nielsen","year":"2008","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.bbadis.2009.09.004_bib111","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s10571-006-9031-2","article-title":"AMPA-induced excitotoxicity increases nuclear levels of CAD, endonuclease G, and acinus and induces chromatin condensation in rat hippocampal pyramidal neurons","volume":"26","author":"Henne","year":"2006","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib112","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nrm2199","article-title":"Signal integration in the endoplasmic reticulum unfolded protein response","volume":"8","author":"Ron","year":"2007","journal-title":"Nat. Rev., Mol. Cell Biol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib113","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1146\/annurev.cellbio.22.010305.104656","article-title":"Cholesterol sensing, trafficking, and esterification","volume":"22","author":"Chang","year":"2006","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib114","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1007\/s00018-007-7383-5","article-title":"Endoplasmic reticulum stress responses","volume":"65","author":"Schroder","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bbadis.2009.09.004_bib115","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.tcb.2003.11.001","article-title":"A trip to the ER: coping with stress","volume":"14","author":"Rutkowski","year":"2004","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib116","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1126\/science.287.5453.664","article-title":"Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1","volume":"287","author":"Urano","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2009.09.004_bib117","doi-asserted-by":"crossref","first-page":"18728","DOI":"10.1074\/jbc.M200903200","article-title":"Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress","volume":"277","author":"Ma","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2009.09.004_bib118","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.ymeth.2004.10.011","article-title":"ER stress signaling by regulated proteolysis of ATF6","volume":"35","author":"Shen","year":"2005","journal-title":"Methods"},{"key":"10.1016\/j.bbadis.2009.09.004_bib119","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/16729","article-title":"Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase","volume":"397","author":"Harding","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2009.09.004_bib120","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1093\/hmg\/ddi312","article-title":"Endoplasmic reticulum stress compromises the ubiquitin-proteasome system","volume":"14","author":"Menendez-Benito","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbadis.2009.09.004_bib121","doi-asserted-by":"crossref","first-page":"e423","DOI":"10.1371\/journal.pbio.0040423","article-title":"Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response","volume":"4","author":"Bernales","year":"2006","journal-title":"PLoS Biol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib122","doi-asserted-by":"crossref","first-page":"9220","DOI":"10.1128\/MCB.01453-06","article-title":"Autophagy is activated for cell survival after endoplasmic reticulum stress","volume":"26","author":"Ogata","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib123","doi-asserted-by":"crossref","first-page":"157","DOI":"10.2174\/156652408784221324","article-title":"The stress rheostat: an interplay between the unfolded protein response (UPR) and autophagy in neurodegeneration","volume":"8","author":"Matus","year":"2008","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.bbadis.2009.09.004_bib124","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.cell.2009.03.048","article-title":"Autophagy suppresses tumorigenesis through elimination of p62","volume":"137","author":"Mathew","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2009.09.004_bib125","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.molcel.2009.01.021","article-title":"Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates","volume":"33","author":"Korolchuk","year":"2009","journal-title":"Mol. Cell."},{"key":"10.1016\/j.bbadis.2009.09.004_bib126","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1083\/jcb.200702115","article-title":"Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease","volume":"179","author":"Filimonenko","year":"2007","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib127","doi-asserted-by":"crossref","first-page":"7260","DOI":"10.1074\/jbc.M509868200","article-title":"Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53","volume":"281","author":"Li","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2009.09.004_bib128","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.tcb.2007.10.003","article-title":"The daily job of night killers: alternative roles of the BCL-2 family in organelle physiology","volume":"18","author":"Hetz","year":"2008","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib129","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1083\/jcb.200305149","article-title":"Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3\/PUMA and activation of the mitochondrial apoptosis pathway","volume":"162","author":"Reimertz","year":"2003","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib130","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1074\/jbc.M409948200","article-title":"Identification of a network involved in thapsigargin-induced apoptosis using a library of small interfering RNA expression vectors","volume":"280","author":"Futami","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2009.09.004_bib131","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1016\/j.cell.2007.04.027","article-title":"ER stress triggers apoptosis by activating BH3-only protein Bim","volume":"129","author":"Puthalakath","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2009.09.004_bib132","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/sj.cdd.4401373","article-title":"Roles of CHOP\/GADD153 in endoplasmic reticulum stress","volume":"11","author":"Oyadomari","year":"2004","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbadis.2009.09.004_bib133","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1128\/MCB.21.4.1249-1259.2001","article-title":"Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state","volume":"21","author":"McCullough","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib134","doi-asserted-by":"crossref","first-page":"99","DOI":"10.2174\/156652406775574587","article-title":"The control of endoplasmic reticulum-initiated apoptosis by the BCL-2 family of proteins","volume":"6","author":"Oakes","year":"2006","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.bbadis.2009.09.004_bib135","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.molcel.2009.02.017","article-title":"BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha","volume":"33","author":"Lisbona","year":"2009","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbadis.2009.09.004_bib136","doi-asserted-by":"crossref","first-page":"e374","DOI":"10.1371\/journal.pbio.0040374","article-title":"Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins","volume":"4","author":"Rutkowski","year":"2006","journal-title":"PLoS Biol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib137","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1126\/science.1123480","article-title":"Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha","volume":"312","author":"Hetz","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2009.09.004_bib138","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/S0006-291X(02)00289-9","article-title":"Human caspase 12 has acquired deleterious mutations","volume":"293","author":"Fischer","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbadis.2009.09.004_bib139","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1083\/jcb.200310015","article-title":"Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death","volume":"165","author":"Hitomi","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib140","doi-asserted-by":"crossref","first-page":"29578","DOI":"10.1074\/jbc.M502685200","article-title":"Caspase-12 and caspase-4 are not required for caspase-dependent endoplasmic reticulum stress-induced apoptosis","volume":"280","author":"Obeng","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2009.09.004_bib141","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1038\/nature04656","article-title":"Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice","volume":"440","author":"Saleh","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2009.09.004_bib142","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0896-6273(03)00355-6","article-title":"JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis","volume":"38","author":"Putcha","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.bbadis.2009.09.004_bib143","doi-asserted-by":"crossref","first-page":"4248","DOI":"10.1091\/mbc.E03-11-0851","article-title":"Nck-dependent activation of extracellular signal-regulated kinase-1 and regulation of cell survival during endoplasmic reticulum stress","volume":"15","author":"Nguyen","year":"2004","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbadis.2009.09.004_bib144","doi-asserted-by":"crossref","first-page":"3071","DOI":"10.1128\/MCB.26.8.3071-3084.2006","article-title":"Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression","volume":"26","author":"Hu","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib145","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbabio.2009.03.010","article-title":"Mitochondrial calcium function and dysfunction in the central nervous system","author":"Nicholls","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2009.09.004_bib146","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1152\/physrev.00004.2005","article-title":"Microdomains of intracellular Ca2+: molecular determinants and functional consequences","volume":"86","author":"Rizzuto","year":"2006","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbadis.2009.09.004_bib147","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1038\/sj.cdd.4401659","article-title":"Transcriptional upregulation of PUMA modulates endoplasmic reticulum calcium pool depletion-induced apoptosis via Bax activation","volume":"12","author":"Luo","year":"2005","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbadis.2009.09.004_bib148","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1073\/pnas.0408352102","article-title":"Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum","volume":"102","author":"Oakes","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2009.09.004_bib149","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1023\/A:1005504210587","article-title":"Mitochondrial calcium signaling driven by the IP3 receptor","volume":"32","author":"Hajnoczky","year":"2000","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.bbadis.2009.09.004_bib150","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1054\/ceca.2000.0169","article-title":"Control of apoptosis by IP(3) and ryanodine receptor driven calcium signals","volume":"28","author":"Hajnoczky","year":"2000","journal-title":"Cell Calcium"},{"key":"10.1016\/j.bbadis.2009.09.004_bib151","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/sj.onc.1210638","article-title":"Endoplasmic reticulum stress induces calcium-dependent permeability transition, mitochondrial outer membrane permeabilization and apoptosis","volume":"27","author":"Deniaud","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.bbadis.2009.09.004_bib152","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nn.2297","article-title":"A role for motoneuron subtype-selective ER stress in disease manifestations of FALS mice","volume":"12","author":"Saxena","year":"2009","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbadis.2009.09.004_bib153","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2007.01.069","article-title":"Endoplasmic reticulum stress response in dendrites of cultured primary neurons","volume":"146","author":"Murakami","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbadis.2009.09.004_bib154","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/sj.cdd.4401778","article-title":"ER stress and neurodegenerative diseases","volume":"13","author":"Lindholm","year":"2006","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbadis.2009.09.004_bib155","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1126\/science.1082324","article-title":"Initiation and synergistic fibrillization of tau and alpha-synuclein","volume":"300","author":"Giasson","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2009.09.004_bib156","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1001\/archneurol.2007.56","article-title":"Protein misfolding and neurodegeneration","volume":"65","author":"Soto","year":"2008","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib157","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1146\/annurev.pathmechdis.3.121806.151434","article-title":"Endoplasmic reticulum stress in disease pathogenesis","volume":"3","author":"Lin","year":"2008","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib158","doi-asserted-by":"crossref","first-page":"4411","DOI":"10.1093\/emboj\/cdf445","article-title":"A mitochondrial specific stress response in mammalian cells","volume":"21","author":"Zhao","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.bbadis.2009.09.004_bib159","doi-asserted-by":"crossref","first-page":"e835","DOI":"10.1371\/journal.pone.0000835","article-title":"The chop gene contains an element for the positive regulation of the mitochondrial unfolded protein response","volume":"2","author":"Horibe","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2009.09.004_bib160","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0072-9752(07)83024-7","article-title":"Oxidative stress and Parkinson's disease","volume":"83","author":"Jenner","year":"2007","journal-title":"Handb. Clin. Neurol."},{"issue":"Suppl 1","key":"10.1016\/j.bbadis.2009.09.004_bib161","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1471-4159.2009.05897.x","article-title":"Oxidative stress and mitochondrial dysfunction as determinants of ischemic neuronal death and survival","volume":"109","author":"Niizuma","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbadis.2009.09.004_bib162","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1111\/j.1471-4159.2006.03907.x","article-title":"Oxidative stress and neurodegeneration: where are we now?","volume":"97","author":"Halliwell","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbadis.2009.09.004_bib163","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.neuroscience.2008.10.015","article-title":"alpha-Ketoglutarate dehydrogenase contributes to production of reactive oxygen species in glutamate-stimulated hippocampal neurons in situ","volume":"158","author":"Zundorf","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbadis.2009.09.004_bib164","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.freeradbiomed.2004.02.013","article-title":"Reactive oxygen species induce different cell death mechanisms in cultured neurons","volume":"36","author":"Valencia","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2009.09.004_bib165","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/j.freeradbiomed.2007.06.020","article-title":"Hydrogen peroxide inhibits caspase-dependent apoptosis by inactivating procaspase-9 in an iron-dependent manner","volume":"43","author":"Barbouti","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2009.09.004_bib166","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/sj.cdd.4400646","article-title":"Oxidative stress induces caspase-independent retinal apoptosis in vitro","volume":"7","author":"Carmody","year":"2000","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbadis.2009.09.004_bib167","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/S0891-5849(00)00366-X","article-title":"Hydrogen peroxide inhibits activation, not activity, of cellular caspase-3 in vivo","volume":"29","author":"Lee","year":"2000","journal-title":"Free. Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2009.09.004_bib168","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.tcb.2007.07.009","article-title":"ROS, mitochondria and the regulation of autophagy","volume":"17","author":"Scherz-Shouval","year":"2007","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib169","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0306-4522(02)00512-2","article-title":"Loss of cardiolipin and mitochondria during programmed neuronal death: evidence of a role for lipid peroxidation and autophagy","volume":"115","author":"Kirkland","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbadis.2009.09.004_bib170","article-title":"Oxidative stress and autophagy in the regulation of lysosome-dependent neuron death","author":"Pivtoraiko","year":"2008","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bbadis.2009.09.004_bib171","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/nrm2393","article-title":"Expansion and evolution of cell death programmes","volume":"9","author":"Degterev","year":"2008","journal-title":"Nat. Rev., Mol. Cell Biol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib172","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nature01034","article-title":"The harlequin mouse mutation downregulates apoptosis-inducing factor","volume":"419","author":"Klein","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2009.09.004_bib173","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1152\/physrev.1999.79.4.1431","article-title":"Ischemic cell death in brain neurons","volume":"79","author":"Lipton","year":"1999","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbadis.2009.09.004_bib174","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0166-2236(99)01401-0","article-title":"Pathobiology of ischaemic stroke: an integrated view","volume":"22","author":"Dirnagl","year":"1999","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.bbadis.2009.09.004_bib175","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1080\/01616412.1998.11740520","article-title":"The temporal profile and morphologic features of neuronal death in human stroke resemble those observed in experimental forebrain ischemia: the potential role of apoptosis","volume":"20","author":"Guglielmo","year":"1998","journal-title":"Neurol. Res."},{"key":"10.1016\/j.bbadis.2009.09.004_bib176","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1046\/j.1365-2990.2000.00218.x","article-title":"Neuronal death in brain infarcts in man","volume":"26","author":"Love","year":"2000","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib177","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/brain\/awh645","article-title":"Apoptosis dominant in the periinfarct area of human ischaemic stroke\u2013a possible target of antiapoptotic treatments","volume":"129","author":"Sairanen","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.bbadis.2009.09.004_bib178","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1385\/CBB:47:1:73","article-title":"Expression of signaling molecules associated with apoptosis in human ischemic stroke tissue","volume":"47","author":"Mitsios","year":"2007","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.bbadis.2009.09.004_bib179","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/1471-2202-8-93","article-title":"A microarray study of gene and protein regulation in human and rat brain following middle cerebral artery occlusion","volume":"8","author":"Mitsios","year":"2007","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.bbadis.2009.09.004_bib180","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0165-3806(00)00110-3","article-title":"Subcellular distribution of calcium and ultrastructural changes after cerebral hypoxia-ischemia in immature rats","volume":"125","author":"Puka-Sundvall","year":"2000","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.bbadis.2009.09.004_bib181","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.neuroscience.2004.03.062","article-title":"Pathogenesis of hippocampal neuronal death after hypoxia-ischemia changes during brain development","volume":"127","author":"Liu","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbadis.2009.09.004_bib182","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1750-3639.2002.tb00452.x","article-title":"Mechanisms of cell death in neurodegenerative diseases: fashion, fiction, and facts","volume":"12","author":"Graeber","year":"2002","journal-title":"Brain Pathol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib183","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/S0166-2236(99)01534-9","article-title":"Mitochondrial membrane potential and neuronal glutamate excitotoxicity: mortality and millivolts","volume":"23","author":"Nicholls","year":"2000","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.bbadis.2009.09.004_bib184","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.coph.2007.10.005","article-title":"Poly(ADP-ribose)polymerase 1 (PARP-1) and postischemic brain damage","volume":"8","author":"Moroni","year":"2008","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib185","doi-asserted-by":"crossref","first-page":"3407","DOI":"10.1002\/jnr.21498","article-title":"Mechanisms of impaired mitochondrial energy metabolism in acute and chronic neurodegenerative disorders","volume":"85","author":"Soane","year":"2007","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bbadis.2009.09.004_bib186","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1007\/s10495-006-0525-7","article-title":"Role of the mitochondrial membrane permeability transition in cell death","volume":"12","author":"Tsujimoto","year":"2007","journal-title":"Apoptosis"},{"key":"10.1016\/j.bbadis.2009.09.004_bib187","doi-asserted-by":"crossref","first-page":"12005","DOI":"10.1073\/pnas.0505294102","article-title":"Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia","volume":"102","author":"Schinzel","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2009.09.004_bib188","doi-asserted-by":"crossref","first-page":"3584","DOI":"10.1002\/jnr.21795","article-title":"Bax shuttling after neonatal hypoxia-ischemia: hyperoxia effects","volume":"86","author":"Gill","year":"2008","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bbadis.2009.09.004_bib189","doi-asserted-by":"crossref","first-page":"9278","DOI":"10.1523\/JNEUROSCI.2826-07.2007","article-title":"Critical role of calpain I in mitochondrial release of apoptosis-inducing factor in ischemic neuronal injury","volume":"27","author":"Cao","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbadis.2009.09.004_bib190","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.nbd.2007.06.009","article-title":"Extended role of necrotic cell death after hypoxia-ischemia-induced neurodegeneration in the neonatal rat","volume":"27","author":"Carloni","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbadis.2009.09.004_bib191","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.neuroscience.2007.06.060","article-title":"Failure to complete apoptosis following neonatal hypoxia-ischemia manifests as \"continuum\" phenotype of cell death and occurs with multiple manifestations of mitochondrial dysfunction in rodent forebrain","volume":"149","author":"Northington","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbadis.2009.09.004_bib192","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1046\/j.1471-4159.2003.01832.x","article-title":"Involvement of apoptosis-inducing factor in neuronal death after hypoxia-ischemia in the neonatal rat brain","volume":"86","author":"Zhu","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbadis.2009.09.004_bib193","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/sj.cdd.4401545","article-title":"The influence of age on apoptotic and other mechanisms of cell death after cerebral hypoxia-ischemia","volume":"12","author":"Zhu","year":"2005","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbadis.2009.09.004_bib194","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s12035-007-8013-9","article-title":"Molecular mechanisms of apoptosis in cerebral ischemia: multiple neuroprotective opportunities","volume":"37","author":"Nakka","year":"2008","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1471-4159.2004.02703.x","article-title":"Cerebral ischemia and the unfolded protein response","volume":"91","author":"DeGracia","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbadis.2009.09.004_bib196","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1097\/01.WCB.0000075009.47474.F9","article-title":"Shutdown of translation: lethal or protective? Unfolded protein response versus apoptosis","volume":"23","author":"Paschen","year":"2003","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.bbadis.2009.09.004_bib197","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1124\/jpet.104.069088","article-title":"Edaravone protects against hypoxia\/ischemia-induced endoplasmic reticulum dysfunction","volume":"311","author":"Qi","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbadis.2009.09.004_bib198","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.brainres.2008.10.032","article-title":"Subcellular stress response and induction of molecular chaperones and folding proteins after transient global ischemia in rats","volume":"1249","author":"Truettner","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.bbadis.2009.09.004_bib199","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s10571-008-9309-7","article-title":"Molecular analysis of endoplasmic reticulum stress response after global forebrain ischemia\/reperfusion in rats: effect of neuroprotectant simvastatin","volume":"29","author":"Urban","year":"2009","journal-title":"Cell Mol. Neurobiol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib200","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1097\/00004647-200304000-00010","article-title":"Dysfunction of the unfolded protein response during global brain ischemia and reperfusion","volume":"23","author":"Kumar","year":"2003","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.bbadis.2009.09.004_bib201","doi-asserted-by":"crossref","first-page":"404","DOI":"10.4161\/auto.5598","article-title":"Autophagic neuron death in neonatal brain ischemia\/hypoxia","volume":"4","author":"Uchiyama","year":"2008","journal-title":"Autophagy"},{"key":"10.1016\/j.bbadis.2009.09.004_bib202","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.nbd.2007.08.005","article-title":"Focal cerebral ischemia induces upregulation of Beclin 1 and autophagy-like cell death","volume":"29","author":"Rami","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbadis.2009.09.004_bib203","doi-asserted-by":"crossref","first-page":"762","DOI":"10.4161\/auto.6412","article-title":"Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways","volume":"4","author":"Wen","year":"2008","journal-title":"Autophagy"},{"key":"10.1016\/j.bbadis.2009.09.004_bib204","doi-asserted-by":"crossref","first-page":"422","DOI":"10.4161\/auto.5778","article-title":"Apoptosis meets autophagy-like cell death in the ischemic penumbra: Two sides of the same coin?","volume":"4","author":"Rami","year":"2008","journal-title":"Autophagy"},{"key":"10.1016\/j.bbadis.2009.09.004_bib205","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.nbd.2008.07.022","article-title":"Protective role of autophagy in neonatal hypoxia-ischemia induced brain injury","volume":"32","author":"Carloni","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbadis.2009.09.004_bib206","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.neuron.2006.09.018","article-title":"ALS: a disease of motor neurons and their nonneuronal neighbors","volume":"52","author":"Boillee","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.bbadis.2009.09.004_bib207","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/nrn1971","article-title":"Molecular biology of amyotrophic lateral sclerosis: insights from genetics","volume":"7","author":"Pasinelli","year":"2006","journal-title":"Nat. Rev., Neurosci."},{"key":"10.1016\/j.bbadis.2009.09.004_bib208","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1056\/NEJM199412223312516","article-title":"Transgenic-mouse model of amyotrophic lateral sclerosis","volume":"331","author":"Gurney","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbadis.2009.09.004_bib209","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.pneurobio.2008.01.001","article-title":"Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS","volume":"85","author":"Turner","year":"2008","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib210","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.mito.2005.01.002","article-title":"Mitochondrial dysfunction and its role in motor neuron degeneration in ALS","volume":"5","author":"Manfredi","year":"2005","journal-title":"Mitochondrion"},{"key":"10.1016\/j.bbadis.2009.09.004_bib211","doi-asserted-by":"crossref","first-page":"6007","DOI":"10.1073\/pnas.0508774103","article-title":"Chronic activation in presymptomatic amyotrophic lateral sclerosis (ALS) mice of a feedback loop involving Fas, Daxx, and FasL","volume":"103","author":"Raoul","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2009.09.004_bib212","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1046\/j.1471-4159.2002.00968.x","article-title":"Temporal patterns of cytokine and apoptosis-related gene expression in spinal cords of the G93A-SOD1 mouse model of amyotrophic lateral sclerosis","volume":"82","author":"Hensley","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbadis.2009.09.004_bib213","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/jnr.1048","article-title":"Systemic administration of antisense p75(NTR) oligodeoxynucleotides rescues axotomised spinal motor neurons","volume":"64","author":"Lowry","year":"2001","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bbadis.2009.09.004_bib214","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1172\/JCI200317610","article-title":"Programmed cell death in amyotrophic lateral sclerosis","volume":"111","author":"Guegan","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2009.09.004_bib215","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1097\/00005072-199905000-00005","article-title":"Neuronal death in amyotrophic lateral sclerosis is apoptosis: possible contribution of a programmed cell death mechanism","volume":"58","author":"Martin","year":"1999","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib216","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1046\/j.0305-1846.2001.00332.x","article-title":"Apoptosis in amyotrophic lateral sclerosis: a review of the evidence","volume":"27","author":"Sathasivam","year":"2001","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib217","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1046\/j.1365-2990.2000.026002150.x","article-title":"Motor neuronal death in sporadic amyotrophic lateral sclerosis (ALS) is not apoptotic. A comparative study of ALS and chronic aluminium chloride neurotoxicity in New Zealand white rabbits","volume":"26","author":"He","year":"2000","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib218","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0022-510X(01)00627-X","article-title":"Early vacuolization and mitochondrial damage in motor neurons of FALS mice are not associated with apoptosis or with changes in cytochrome oxidase histochemical reactivity","volume":"191","author":"Bendotti","year":"2001","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.bbadis.2009.09.004_bib219","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1007\/s004010100438","article-title":"Apoptosis signals in sporadic amyotrophic lateral sclerosis: an immunocytochemical study","volume":"102","author":"Embacher","year":"2001","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib220","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0304-3940(96)12314-4","article-title":"Ultrastructural study of synapses in the anterior horn neurons of patients with amyotrophic lateral sclerosis","volume":"204","author":"Sasaki","year":"1996","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbadis.2009.09.004_bib221","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1007\/s004010050716","article-title":"Immunocytochemical and ultrastructural study of pericapillary rosettes in amyotrophic lateral sclerosis","volume":"94","author":"Sasaki","year":"1997","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib222","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1097\/00005072-198409000-00001","article-title":"Fine structural observations of neurofilamentous changes in amyotrophic lateral sclerosis","volume":"43","author":"Hirano","year":"1984","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib223","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/ana.410390210","article-title":"Ultrastructural evidence for altered calcium in motor nerve terminals in amyotropic lateral sclerosis","volume":"39","author":"Siklos","year":"1996","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib224","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0022-510X(98)00008-2","article-title":"Impairment of mitochondrial function in skeletal muscle of patients with amyotrophic lateral sclerosis","volume":"156","author":"Wiedemann","year":"1998","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.bbadis.2009.09.004_bib225","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1093\/brain\/123.7.1339","article-title":"Mitochondrial DNA abnormalities in skeletal muscle of patients with sporadic amyotrophic lateral sclerosis","volume":"123","author":"Vielhaber","year":"2000","journal-title":"Brain"},{"key":"10.1016\/j.bbadis.2009.09.004_bib226","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1002\/1531-8249(199911)46:5<787::AID-ANA17>3.0.CO;2-8","article-title":"Mitochondrial enzyme activity in amyotrophic lateral sclerosis: implications for the role of mitochondria in neuronal cell death","volume":"46","author":"Borthwick","year":"1999","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib227","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.expneurol.2005.07.020","article-title":"Muscular mitochondrial function in amyotrophic lateral sclerosis is progressively altered as the disease develops: a temporal study in man","volume":"198","author":"Echaniz-Laguna","year":"2006","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib228","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1046\/j.0022-3042.2001.00731.x","article-title":"Mitochondrial DNA and respiratory chain function in spinal cords of ALS patients","volume":"80","author":"Wiedemann","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbadis.2009.09.004_bib229","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.1093\/brain\/awm190","article-title":"Oxidative and endoplasmic reticulum stress interplay in sporadic amyotrophic lateral sclerosis","volume":"130","author":"Ilieva","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.bbadis.2009.09.004_bib230","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1046\/j.1471-4159.1997.69052064.x","article-title":"Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis","volume":"69","author":"Ferrante","year":"1997","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbadis.2009.09.004_bib231","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1111\/j.1460-9568.1993.tb00929.x","article-title":"Interleukin-6 and transforming growth factor-beta 1 mRNAs are induced in rat facial nucleus following motoneuron axotomy","volume":"5","author":"Kiefer","year":"1993","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bbadis.2009.09.004_bib232","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s12035-008-8036-x","article-title":"Calpain-mediated signaling mechanisms in neuronal injury and neurodegeneration","volume":"38","author":"Vosler","year":"2008","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib233","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.nbd.2008.02.009","article-title":"Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis","volume":"30","author":"Atkin","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbadis.2009.09.004_bib234","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1006\/nbdi.2000.0299","volume":"7","author":"Jaarsma","year":"2000","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbadis.2009.09.004_bib235","doi-asserted-by":"crossref","first-page":"29626","DOI":"10.1074\/jbc.M203065200","article-title":"Mutated human SOD1 causes dysfunction of oxidative phosphorylation in mitochondria of transgenic mice","volume":"277","author":"Mattiazzi","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2009.09.004_bib236","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.neuron.2004.06.016","article-title":"Toxicity of familial ALS-linked SOD1 mutants from selective recruitment to spinal mitochondria","volume":"43","author":"Liu","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.bbadis.2009.09.004_bib237","doi-asserted-by":"crossref","first-page":"4022","DOI":"10.1073\/pnas.0712209105","article-title":"Selective association of misfolded ALS-linked mutant SOD1 with the cytoplasmic face of mitochondria","volume":"105","author":"Vande Velde","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2009.09.004_bib238","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.1523\/JNEUROSCI.18-09-03241.1998","article-title":"Massive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral sclerosis in mice expressing a mutant SOD1","volume":"18","author":"Kong","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbadis.2009.09.004_bib239","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/cne.21160","article-title":"Motor neuron degeneration in amyotrophic lateral sclerosis mutant superoxide dismutase-1 transgenic mice: mechanisms of mitochondriopathy and cell death","volume":"500","author":"Martin","year":"2007","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib240","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.nbd.2008.08.004","article-title":"Inflammatory cytokines increase mitochondrial damage in motoneuronal cells expressing mutant SOD1","volume":"32","author":"Ferri","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbadis.2009.09.004_bib241","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.expneurol.2009.02.015","article-title":"The mitochondrial permeability transition pore in motor neurons: Involvement in the pathobiology of ALS mice","volume":"218","author":"Martin","year":"2009","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib242","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1146\/annurev.neuro.31.061307.090711","article-title":"Role of axonal transport in neurodegenerative diseases","volume":"31","author":"De Vos","year":"2008","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.bbadis.2009.09.004_bib243","doi-asserted-by":"crossref","DOI":"10.1089\/ars.2009.2604","article-title":"Mitochondrial function, morphology, and axonal transport in amyotrophic lateral sclerosis","author":"Magran\u00e9","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bbadis.2009.09.004_bib244","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1093\/hmg\/ddm226","article-title":"Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content","volume":"16","author":"De Vos","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbadis.2009.09.004_bib245","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.bbadis.2006.05.002","article-title":"The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis","volume":"1762","author":"Van Den Bosch","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2009.09.004_bib246","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1523\/JNEUROSCI.4289-06.2007","article-title":"Endoplasmic reticulum stress inhibition protects against excitotoxic neuronal injury in the rat brain","volume":"27","author":"Sokka","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbadis.2009.09.004_bib247","doi-asserted-by":"crossref","first-page":"30152","DOI":"10.1074\/jbc.M603393200","article-title":"Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1","volume":"281","author":"Atkin","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2009.09.004_bib248","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/S0006-291X(03)00353-X","article-title":"Mutant SOD1 linked to familial amyotrophic lateral sclerosis, but not wild-type SOD1, induces ER stress in COS7 cells and transgenic mice","volume":"303","author":"Tobisawa","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbadis.2009.09.004_bib249","doi-asserted-by":"crossref","first-page":"6025","DOI":"10.1073\/pnas.0509227103","article-title":"Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model","volume":"103","author":"Kikuchi","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2009.09.004_bib250","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1111\/j.1460-9568.2005.04389.x","article-title":"ATF3 expression precedes death of spinal motoneurons in amyotrophic lateral sclerosis-SOD1 transgenic mice and correlates with c-Jun phosphorylation, CHOP expression, somato-dendritic ubiquitination and Golgi fragmentation","volume":"22","author":"Vlug","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bbadis.2009.09.004_bib251","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1101\/gad.1640108","article-title":"ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1","volume":"22","author":"Nishitoh","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbadis.2009.09.004_bib252","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1038\/sj.cdd.4402166","article-title":"The proapoptotic BCL-2 family member BIM mediates motoneuron loss in a model of amyotrophic lateral sclerosis","volume":"14","author":"Hetz","year":"2007","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbadis.2009.09.004_bib253","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1111\/j.1471-4159.2007.05053.x","article-title":"Superoxide dismutase 1 mutants related to amyotrophic lateral sclerosis induce endoplasmic stress in neuro2a cells","volume":"104","author":"Oh","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbadis.2009.09.004_bib254","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1111\/j.1471-4159.2008.05799.x","article-title":"Recruitment of mitochondria into apoptotic signaling correlates with the presence of inclusions formed by amyotrophic lateral sclerosis-associated SOD1 mutations","volume":"108","author":"Soo","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbadis.2009.09.004_bib255","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.nbd.2004.12.007","article-title":"Accumulation of human SOD1 and ubiquitinated deposits in the spinal cord of SOD1G93A mice during motor neuron disease progression correlates with a decrease of proteasome","volume":"18","author":"Cheroni","year":"2005","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbadis.2009.09.004_bib256","doi-asserted-by":"crossref","first-page":"290","DOI":"10.4161\/auto.5524","article-title":"Altered macroautophagy in the spinal cord of SOD1 mutant mice","volume":"4","author":"Li","year":"2008","journal-title":"Autophagy"},{"key":"10.1016\/j.bbadis.2009.09.004_bib257","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.mcn.2005.03.003","article-title":"Protein retention in the endoplasmic reticulum, blockade of programmed cell death and autophagy selectively occur in spinal cord motoneurons after glutamate receptor-mediated injury","volume":"29","author":"Tarabal","year":"2005","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.bbadis.2009.09.004_bib258","doi-asserted-by":"crossref","DOI":"10.1007\/s00415-009-5069-7","article-title":"Amyotrophic lateral sclerosis, frontotemporal dementia and beyond: the TDP-43 diseases","author":"Geser","year":"2009","journal-title":"J. Neurol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib259","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.neurobiolaging.2005.08.012","article-title":"Protein aggregation in the pathogenesis of familial and sporadic Parkinson's disease","volume":"27","author":"McNaught","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbadis.2009.09.004_bib260","first-page":"1792","article-title":"Mitochondrial dysfunction in the limelight of Parkinson's disease pathogenesis","author":"Banerjee","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2009.09.004_bib261","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1007\/s10495-008-0309-3","article-title":"Cell death pathways in Parkinson's disease: proximal triggers, distal effectors, and final steps","volume":"14","author":"Levy","year":"2009","journal-title":"Apoptosis"},{"key":"10.1016\/j.bbadis.2009.09.004_bib262","doi-asserted-by":"crossref","first-page":"161S","DOI":"10.1212\/WNL.47.6_Suppl_3.161S","article-title":"Oxidative stress and the pathogenesis of Parkinson's disease","volume":"47 Suppl","author":"Jenner","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.bbadis.2009.09.004_bib263","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1111\/j.1471-4159.1990.tb05809.x","article-title":"Anatomic and disease specificity of NADH CoQ1 reductase (complex I) deficiency in Parkinson's disease","volume":"55","author":"Schapira","year":"1990","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbadis.2009.09.004_bib264","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1046\/j.1471-4159.2001.00160.x","article-title":"Is Bax a mitochondrial mediator in apoptotic death of dopaminergic neurons in Parkinson's disease?","volume":"76","author":"Hartmann","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbadis.2009.09.004_bib265","first-page":"25","article-title":"Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease","volume":"12","author":"Anglade","year":"1997","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib266","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/j.1750-3639.2003.tb00478.x","article-title":"Localization of phosphorylated ERK\/MAP kinases to mitochondria and autophagosomes in Lewy body diseases","volume":"13","author":"Zhu","year":"2003","journal-title":"Brain Pathol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib267","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1126\/science.6823561","article-title":"Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis","volume":"219","author":"Langston","year":"1983","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2009.09.004_bib268","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1002\/bies.10067","article-title":"Animal models of Parkinson's disease","volume":"24","author":"Betarbet","year":"2002","journal-title":"Bioessays"},{"key":"10.1016\/j.bbadis.2009.09.004_bib269","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1007\/s11064-008-9747-0","article-title":"Generation of reactive oxygen species by mitochondrial complex I: implications in neurodegeneration","volume":"33","author":"Fato","year":"2008","journal-title":"Neurochem. Res."},{"issue":"Suppl 2","key":"10.1016\/j.bbadis.2009.09.004_bib270","first-page":"S16","article-title":"Functional models of Parkinson's disease: a valuable tool in the development of novel therapies","volume":"64","author":"Jenner","year":"2008","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib271","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0896-6273(03)00568-3","article-title":"Parkinson's disease: mechanisms and models","volume":"39","author":"Dauer","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.bbadis.2009.09.004_bib272","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1111\/j.1471-4159.2005.03329.x","article-title":"Apoptosis inducing factor mediates caspase-independent 1-methyl-4-phenylpyridinium toxicity in dopaminergic cells","volume":"94","author":"Chu","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbadis.2009.09.004_bib273","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1097\/WNR.0b013e32801b3ca6","article-title":"Rotenone and MPP+ preferentially redistribute apoptosis-inducing factor in apoptotic dopamine neurons","volume":"18","author":"Lim","year":"2007","journal-title":"NeuroReport"},{"key":"10.1016\/j.bbadis.2009.09.004_bib274","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s12017-008-8047-9","article-title":"Coupling endoplasmic reticulum stress to the cell death program in dopaminergic cells: effect of paraquat","volume":"10","author":"Chinta","year":"2008","journal-title":"Neuromol. Med."},{"key":"10.1016\/j.bbadis.2009.09.004_bib275","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.conb.2007.04.010","article-title":"Pink1, Parkin, DJ-1 and mitochondrial dysfunction in Parkinson's disease","volume":"17","author":"Dodson","year":"2007","journal-title":"Curr. Opin. Neurobiol."},{"issue":"Suppl 5","key":"10.1016\/j.bbadis.2009.09.004_bib276","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00415-008-5011-4","article-title":"Update on the pathogenesis of Parkinson's disease","volume":"255","author":"Schulz","year":"2008","journal-title":"J. Neurol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib277","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1097\/WNR.0b013e32831c50df","article-title":"Molecular basis of Parkinson's disease","volume":"20","author":"Yang","year":"2009","journal-title":"NeuroReport"},{"issue":"Suppl 6","key":"10.1016\/j.bbadis.2009.09.004_bib278","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1002\/mds.10557","article-title":"Neuropathological spectrum of synucleinopathies","volume":"18","author":"Jellinger","year":"2003","journal-title":"Mov. Disord."},{"key":"10.1016\/j.bbadis.2009.09.004_bib279","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1750-1326-4-9","article-title":"alpha-Synuclein and neuronal cell death","volume":"4","author":"Cookson","year":"2009","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.bbadis.2009.09.004_bib280","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1126\/science.276.5321.2045","article-title":"Mutation in the alpha-synuclein gene identified in families with Parkinson's disease","volume":"276","author":"Polymeropoulos","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2009.09.004_bib281","doi-asserted-by":"crossref","first-page":"9089","DOI":"10.1074\/jbc.M710012200","article-title":"Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain","volume":"283","author":"Devi","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2009.09.004_bib282","doi-asserted-by":"crossref","first-page":"12305","DOI":"10.1523\/JNEUROSCI.3088-08.2008","article-title":"Optical reporters for the conformation of alpha-synuclein reveal a specific interaction with mitochondria","volume":"28","author":"Nakamura","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbadis.2009.09.004_bib283","doi-asserted-by":"crossref","first-page":"3801","DOI":"10.1093\/hmg\/ddi396","article-title":"Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity","volume":"14","author":"Smith","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbadis.2009.09.004_bib284","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/77060","article-title":"Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase","volume":"25","author":"Shimura","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbadis.2009.09.004_bib285","doi-asserted-by":"crossref","first-page":"18614","DOI":"10.1074\/jbc.M401135200","article-title":"Mitochondrial dysfunction and oxidative damage in parkin-deficient mice","volume":"279","author":"Palacino","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2009.09.004_bib286","doi-asserted-by":"crossref","first-page":"12413","DOI":"10.1523\/JNEUROSCI.0719-07.2007","article-title":"Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin","volume":"27","author":"Exner","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbadis.2009.09.004_bib287","doi-asserted-by":"crossref","first-page":"13843","DOI":"10.1074\/jbc.M808515200","article-title":"Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission","volume":"284","author":"Dagda","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2009.09.004_bib288","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1038\/ncb1644","article-title":"The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1","volume":"9","author":"Plun-Favreau","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib289","doi-asserted-by":"crossref","first-page":"14500","DOI":"10.1523\/JNEUROSCI.5141-08.2008","article-title":"Loss-of-function analysis suggests that Omi\/HtrA2 is not an essential component of the PINK1\/PARKIN pathway in vivo","volume":"28","author":"Yun","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbadis.2009.09.004_bib290","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1093\/hmg\/ddi215","article-title":"Loss of function mutations in the gene encoding Omi\/HtrA2 in Parkinson's disease","volume":"14","author":"Strauss","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbadis.2009.09.004_bib291","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/sj.embor.7400074","article-title":"DJ-1 has a role in antioxidative stress to prevent cell death","volume":"5","author":"Taira","year":"2004","journal-title":"EMBO Rep."},{"key":"10.1016\/j.bbadis.2009.09.004_bib292","doi-asserted-by":"crossref","first-page":"21418","DOI":"10.1074\/jbc.M413955200","article-title":"Age-dependent motor deficits and dopaminergic dysfunction in DJ-1 null mice","volume":"280","author":"Chen","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2009.09.004_bib293","doi-asserted-by":"crossref","first-page":"5215","DOI":"10.1073\/pnas.0501282102","article-title":"Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and oxidative stress","volume":"102","author":"Kim","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2009.09.004_bib294","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1111\/j.1471-4159.2009.06020.x","article-title":"Silencing DJ-1 reveals its contribution in paraquat-induced autophagy","volume":"109","author":"Gonzalez-Polo","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbadis.2009.09.004_bib295","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1172\/JCI37617","article-title":"Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation","volume":"119","author":"Xiong","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2009.09.004_bib296","doi-asserted-by":"crossref","first-page":"23731","DOI":"10.1074\/jbc.M801918200","article-title":"Aberrant interaction between Parkinson disease-associated mutant UCH-L1 and the lysosomal receptor for chaperone-mediated autophagy","volume":"283","author":"Kabuta","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2009.09.004_bib297","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.neuron.2006.10.008","article-title":"The familial Parkinsonism gene LRRK2 regulates neurite process morphology","volume":"52","author":"MacLeod","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.bbadis.2009.09.004_bib298","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1038\/emboj.2008.163","article-title":"Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila","volume":"27","author":"Imai","year":"2008","journal-title":"EMBO J."},{"key":"10.1016\/j.bbadis.2009.09.004_bib299","doi-asserted-by":"crossref","first-page":"14363","DOI":"10.1523\/JNEUROSCI.3928-08.2008","article-title":"RTP801 is induced in Parkinson's disease and mediates neuron death by inhibiting Akt phosphorylation\/activation","volume":"28","author":"Malagelada","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbadis.2009.09.004_bib300","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes","volume":"72","author":"MacDonald","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2009.09.004_bib301","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/35039051","article-title":"Molecular genetics: unmasking polyglutamine triggers in neurodegenerative disease","volume":"1","author":"Gusella","year":"2000","journal-title":"Nat. Rev., Neurosci."},{"key":"10.1016\/j.bbadis.2009.09.004_bib302","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1196\/annals.1427.018","article-title":"Mitochondria and Huntington's disease pathogenesis: insight from genetic and chemical models","volume":"1147","author":"Browne","year":"2008","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.bbadis.2009.09.004_bib303","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1042\/BJ20071619","article-title":"Huntington's disease: from pathology and genetics to potential therapies","volume":"412","author":"Imarisio","year":"2008","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbadis.2009.09.004_bib304","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.neuron.2005.03.025","article-title":"Pathological cell-cell interactions elicited by a neuropathogenic form of mutant Huntingtin contribute to cortical pathogenesis in HD mice","volume":"46","author":"Gu","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.bbadis.2009.09.004_bib305","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1111\/j.1460-9568.2008.06310.x","article-title":"Mechanisms of neurodegeneration in Huntington's disease","volume":"27","author":"Gil","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bbadis.2009.09.004_bib306","doi-asserted-by":"crossref","first-page":"91","DOI":"10.4161\/auto.5201","article-title":"A stress sensitive ER membrane-association domain in Huntingtin protein defines a potential role for Huntingtin in the regulation of autophagy","volume":"4","author":"Atwal","year":"2008","journal-title":"Autophagy"},{"key":"10.1016\/j.bbadis.2009.09.004_bib307","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1093\/hmg\/ddh162","article-title":"Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release","volume":"13","author":"Choo","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbadis.2009.09.004_bib308","doi-asserted-by":"crossref","first-page":"5780","DOI":"10.1074\/jbc.M704704200","article-title":"Calcium homeostasis and mitochondrial dysfunction in striatal neurons of Huntington disease","volume":"283","author":"Lim","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2009.09.004_bib309","doi-asserted-by":"crossref","first-page":"13614","DOI":"10.1523\/JNEUROSCI.3455-07.2007","article-title":"Mitochondrial sensitivity and altered calcium handling underlie enhanced NMDA-induced apoptosis in YAC128 model of Huntington's disease","volume":"27","author":"Fernandes","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbadis.2009.09.004_bib310","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.pneurobio.2006.11.003","article-title":"N-methyl-D-aspartate (NMDA) receptor function and excitotoxicity in Huntington's disease","volume":"81","author":"Fan","year":"2007","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib311","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1093\/hmg\/ddh082","article-title":"Striatal cells from mutant huntingtin knock-in mice are selectively vulnerable to mitochondrial complex II inhibitor-induced cell death through a non-apoptotic pathway","volume":"13","author":"Ruan","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbadis.2009.09.004_bib312","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s00401-004-0957-5","article-title":"Expression pattern of apoptosis-related markers in Huntington's disease","volume":"109","author":"Vis","year":"2005","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib313","doi-asserted-by":"crossref","first-page":"3308","DOI":"10.1101\/gad.1673408","article-title":"Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity","volume":"22","author":"Duennwald","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbadis.2009.09.004_bib314","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.yexcr.2007.12.025","article-title":"Inhibition of endoplasmic reticulum stress counteracts neuronal cell death and protein aggregation caused by N-terminal mutant huntingtin proteins","volume":"314","author":"Reijonen","year":"2008","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbadis.2009.09.004_bib315","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1093\/hmg\/9.19.2799","article-title":"Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells","volume":"9","author":"Trettel","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbadis.2009.09.004_bib316","doi-asserted-by":"crossref","first-page":"18167","DOI":"10.1074\/jbc.M109.018325","article-title":"RRS1 is involved in endoplasmic reticulum stress response in Huntington's disease","volume":"284","author":"Carnemolla","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2009.09.004_bib317","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/cdd.2008.110","article-title":"Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies","volume":"16","author":"Sarkar","year":"2008","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbadis.2009.09.004_bib318","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.expneurol.2009.03.042","article-title":"Amyloid beta, mitochondrial structural and functional dynamics in Alzheimer's disease","volume":"218","author":"Reddy","year":"2009","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbadis.2009.09.004_bib319","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1111\/j.1471-4159.2009.06067.x","article-title":"Amyloid precursor protein promotes endoplasmic reticulum stress-induced cell death via C\/EBP homologous protein-mediated pathway","volume":"109","author":"Takahashi","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbadis.2009.09.004_bib320","doi-asserted-by":"crossref","first-page":"4081","DOI":"10.1242\/jcs.019265","article-title":"Autophagy, amyloidogenesis and Alzheimer disease","volume":"120","author":"Nixon","year":"2007","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.bbadis.2009.09.004_bib321","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1038\/nn1988","article-title":"Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease","volume":"10","author":"Lobsiger","year":"2007","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbadis.2009.09.004_bib322","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/j.yexcr.2006.01.026","article-title":"Relative timing of redistribution of cytochrome c and Smac\/DIABLO from mitochondria during apoptosis assessed by double immunocytochemistry on mammalian cells","volume":"312","author":"Lim","year":"2006","journal-title":"Exp. Cell Res."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443909002154?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443909002154?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T13:01:23Z","timestamp":1710594083000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443909002154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":322,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["S0925443909002154"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2009.09.004","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2010,1]]}}}