{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:45:08Z","timestamp":1792431908762,"version":"4.5.0"},"reference-count":91,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,11,20]],"date-time":"2014-11-20T00:00:00Z","timestamp":1416441600000},"content-version":"vor","delay-in-days":1450,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1016\/j.bbadis.2010.07.009","type":"journal-article","created":{"date-parts":[[2010,7,16]],"date-time":"2010-07-16T05:15:45Z","timestamp":1279257345000},"page":"1150-1158","source":"Crossref","is-referenced-by-count":183,"title":["Phosphoregulation of the Na\u2013K\u20132Cl and K\u2013Cl cotransporters by the WNK kinases"],"prefix":"10.1016","volume":"1802","author":[{"given":"Kristopher T.","family":"Kahle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse","family":"Rinehart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard P.","family":"Lifton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2010.07.009_bb0005","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1126\/science.1062844","article-title":"Human hypertension caused by mutations in WNK kinases","volume":"293","author":"Wilson","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2010.07.009_bb0010","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/ng1271","article-title":"WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion","volume":"35","author":"Kahle","year":"2003","journal-title":"Nat Genet"},{"key":"10.1016\/j.bbadis.2010.07.009_bb0015","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1146\/annurev.physiol.70.113006.100651","article-title":"Molecular physiology of the WNK kinases","volume":"70","author":"Kahle","year":"2008","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.bbadis.2010.07.009_bb0020","doi-asserted-by":"crossref","first-page":"16795","DOI":"10.1074\/jbc.275.22.16795","article-title":"WNK1, a novel mammalian serine\/threonine protein kinase lacking the catalytic lysine in subdomain II","volume":"275","author":"Xu","year":"2000","journal-title":"J Biol Chem"},{"issue":"7","key":"10.1016\/j.bbadis.2010.07.009_bb0025","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/j.str.2004.04.014","article-title":"Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension","volume":"12","author":"Min","year":"2004","journal-title":"Structure"},{"key":"10.1016\/j.bbadis.2010.07.009_bb0030","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S0962-8924(01)01980-8","article-title":"The Ste20 group kinases as regulators of MAP kinase cascades","volume":"11","author":"Dan","year":"2001","journal-title":"Trends Cell Biol"},{"issue":"39","key":"10.1016\/j.bbadis.2010.07.009_bb0035","doi-asserted-by":"crossref","first-page":"5562","DOI":"10.1038\/sj.onc.1204726","article-title":"WNK kinases, a novel protein kinase subfamily in multicellular organisms","volume":"20","author":"Ver\u00edssimo","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.bbadis.2010.07.009_bb0040","doi-asserted-by":"crossref","first-page":"26653","DOI":"10.1074\/jbc.M502598200","article-title":"Properties of WNK1 and implications for other family members","volume":"280","author":"Lenertz","year":"2005","journal-title":"J Biol Chem"},{"issue":"5","key":"10.1016\/j.bbadis.2010.07.009_bb0045","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1172\/JCI22452","article-title":"Mechanisms of WNK1 and WNK4 interaction in the regulation of thiazide-sensitive NaCl cotransport","volume":"115","author":"Yang","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bbadis.2010.07.009_bb0050","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1073\/pnas.0308434100","article-title":"WNK4 regulates apical and basolateral Cl\u2212 flux in extrarenal epithelia","volume":"101","author":"Kahle","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bbadis.2010.07.009_bb0055","doi-asserted-by":"crossref","first-page":"16783","DOI":"10.1073\/pnas.0508307102","article-title":"WNK3 modulates transport of Cl\u2212 in 19 and out of cells: implications for control of cell volume and neuronal excitability","volume":"102","author":"Kahle","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bbadis.2010.07.009_bb0060","doi-asserted-by":"crossref","first-page":"C134","DOI":"10.1152\/ajpcell.00037.2005","article-title":"Volume sensitivity of cation-chloride cotransporters is modulated by the interaction of two kinases: SPAK and WNK4","volume":"290","author":"Gagnon","year":"2006","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.bbadis.2010.07.009_bb0065","doi-asserted-by":"crossref","first-page":"C1191","DOI":"10.1152\/ajpcell.1993.265.5.C1191","article-title":"In defense of cell volume?","volume":"265","author":"Parker","year":"1993","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.bbadis.2010.07.009_bb0070","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1159\/000016357","article-title":"K\u2013Cl cotransport: properties and molecular mechanism","volume":"10","author":"Lauf","year":"2000","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.bbadis.2010.07.009_bb0075","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S0005-2736(02)00586-2","article-title":"Regulation of Na\u2013K\u20132Cl cotransport by phosphorylation and protein\u2013protein interactions","volume":"1566","author":"Flatman","year":"2002","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.bbadis.2010.07.009_bb0080","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s00232-004-0695-6","article-title":"Regulation of K\u2013Cl cotransport: from function to genes","volume":"201","author":"Adragna","year":"2004","journal-title":"J Membr Biol"},{"key":"10.1016\/j.bbadis.2010.07.009_bb0085","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1007\/s00424-003-1066-3","article-title":"Molecular physiology of cation-coupledCl\u2212 cotransport: the SLC12 family","volume":"447","author":"Hebert","year":"2004","journal-title":"Pfl\u00fcgers Arch"},{"key":"10.1016\/j.bbadis.2010.07.009_bb0090","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1073\/pnas.242728499","article-title":"WNK1, a kinase mutated in inherited hypertension with hyperkalemia, localizes to diverse Cl\u2212-transporting epithelia","volume":"100","author":"Choate","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bbadis.2010.07.009_bb0095","doi-asserted-by":"crossref","first-page":"50812","DOI":"10.1074\/jbc.M208108200","article-title":"Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1)","volume":"277","author":"Piechotta","year":"2002","journal-title":"J Biol Chem"},{"issue":"6","key":"10.1016\/j.bbadis.2010.07.009_bb0100","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1002\/(SICI)1097-4695(19971120)33:6<781::AID-NEU6>3.0.CO;2-5","article-title":"Expression of the Na\u2013K\u20132Cl0 cotransporter is developmentally regulated in postnatal rat brains: a possible mechanism underlying GABA's excitatory role in immature brain","volume":"33","author":"Plotkin","year":"1997","journal-title":"J Neurobiol"},{"key":"10.1016\/j.bbadis.2010.07.009_bb0105","doi-asserted-by":"crossref","first-page":"27347","DOI":"10.1074\/jbc.M301899200","article-title":"PASK (proline alanine-rich STE20-related kinase), a regulatory kinase of the Na\u2013K\u2013Cl cotrans-porter (NKCC1)","volume":"278","author":"Dowd","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bbadis.2010.07.009_bb0110","doi-asserted-by":"crossref","first-page":"16777","DOI":"10.1073\/pnas.0508303102","article-title":"WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl\u2212 cotransporters required for normal blood pressure homeostasis","volume":"102","author":"Rinehart","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bbadis.2010.07.009_bb0115","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1152\/physiol.00015.2006","article-title":"WNK protein kinases modulate cellular Cl\u2212 flux by altering the phosphorylation state of the Na\u2013K\u2013Cl and K\u2013Cl cotransporters","volume":"21","author":"Kahle","year":"2006","journal-title":"Physiology (Bethesda)"},{"issue":"2","key":"10.1016\/j.bbadis.2010.07.009_bb0120","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1042\/BJ20071324","article-title":"SPAK and OSR1: STE20 kinases involved in the regulation of ion homoeostasis and volume control in mammalian cells","volume":"409","author":"Delpire","year":"2008","journal-title":"Biochem J"},{"issue":"7","key":"10.1016\/j.bbadis.2010.07.009_bb0125","first-page":"2496","article-title":"Mutations in the nervous system\u2014specific HSN2 exon of WNK1 cause hereditary sensory neuropathy type II","volume":"118","author":"Shekarabi","year":"2008","journal-title":"J Clin Invest"},{"issue":"3","key":"10.1016\/j.bbadis.2010.07.009_bb0130","doi-asserted-by":"crossref","first-page":"C915","DOI":"10.1152\/ajpcell.00126.2007","article-title":"Evolutionarily conserved WNK and Ste20 kinases are essential for acute volume recovery and survival after hypertonic shrinkage in Caenorhabditis elegans","volume":"293","author":"Choe","year":"2007","journal-title":"Am J Physiol Cell Physiol"},{"issue":"5","key":"10.1016\/j.bbadis.2010.07.009_bb0135","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1111\/j.1438-8677.2008.00072.x","article-title":"The plant WNK gene family and regulation of flowering time in Arabidopsis","volume":"10","author":"Wang","year":"2008","journal-title":"Plant Biol (Stuttg)"},{"key":"10.1016\/j.bbadis.2010.07.009_bb0140","doi-asserted-by":"crossref","DOI":"10.1038\/ki.2010.103","article-title":"Multigene kinase network, kidney transport, and salt in essential hypertension","author":"Welling","year":"2010","journal-title":"Kidney Int"},{"issue":"2","key":"10.1016\/j.bbadis.2010.07.009_bb0145","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1085\/jgp.200409215","article-title":"GCK-3, a newly identified Ste20 kinase, binds to and regulates the activity of a cell cycle-dependent ClC anion channel","volume":"125","author":"Denton","year":"2005","journal-title":"J Gen Physiol"},{"key":"10.1016\/j.bbadis.2010.07.009_bb0150","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1152\/physrev.00011.2004","article-title":"Molecular physiology and pathophysiology of electroneutral cation chloride cotrans-porters","volume":"85","author":"Gamba","year":"2005","journal-title":"Physiol Rev"},{"key":"10.1016\/j.bbadis.2010.07.009_bb0155","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/ng0196-24","article-title":"Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na\u2013Cl cotransporter","volume":"12","author":"Simon","year":"1996","journal-title":"Nat Genet"},{"key":"10.1016\/j.bbadis.2010.07.009_bb0160","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/ng0696-183","article-title":"Bartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na\u2013K\u20132Cl cotransporter NKCC2","volume":"13","author":"Simon","year":"1996","journal-title":"Nat Genet"},{"key":"10.1016\/j.bbadis.2010.07.009_bb0165","doi-asserted-by":"crossref","first-page":"16237","DOI":"10.1074\/jbc.271.27.16237","article-title":"Molecular cloning and functional expression of the K\u2013Cl cotransporter from rabbit, rat and human. A new member of the cation-chloride cotransporter family.","volume":"271","author":"Gillen","year":"1996","journal-title":"J Biol Chem"},{"issue":"27","key":"10.1016\/j.bbadis.2010.07.009_bb0170","doi-asserted-by":"crossref","first-page":"16245","DOI":"10.1074\/jbc.271.27.16245","article-title":"Molecular characterization of a putative K\u2013Cl cotransporter in rat brain. A neuronal-specific isoform","volume":"271","author":"Payne","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bbadis.2010.07.009_bb0175","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1023\/B:NERE.0000010432.44566.21","article-title":"Electroneutral cation-chloride cotransporters in the central nervous system","volume":"29","author":"Mercado","year":"2004","journal-title":"Neurochem Res"},{"key":"10.1016\/j.bbadis.2010.07.009_bb0180","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/ng1002","article-title":"The K\u2013Cl cotransporter KCC3 is mutant in a severe peripheral neuropathy associated with agenesis of the corpus callosum","volume":"32","author":"Howard","year":"2002","journal-title":"Nat Genet"},{"key":"10.1016\/j.bbadis.2010.07.009_bb0185","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1038\/416874a","article-title":"Related articles, links deafness and renal tubular acidosis in mice lacking the K\u2013Cl cotransporter Kcc4","volume":"416","author":"Boettger","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2010.07.009_bb0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000016269","article-title":"The diversity of volume regulatory mechanisms","volume":"8","author":"Lang","year":"1998","journal-title":"Cell Physiol Biochem"},{"issue":"1","key":"10.1016\/j.bbadis.2010.07.009_bb0195","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1152\/physrev.00037.2007","article-title":"Physiology of cell volume regulation in vertebrates","volume":"89","author":"Hoffmann","year":"2009","journal-title":"Physiol Rev"},{"issue":"1\u20134","key":"10.1016\/j.bbadis.2010.07.009_bb0200","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1152\/advan.00034.2004","article-title":"Cellular volume homeostasis","volume":"28","author":"Strange","year":"2004","journal-title":"Adv Physiol Educ"},{"key":"10.1016\/j.bbadis.2010.07.009_bb0205","doi-asserted-by":"crossref","first-page":"C1422","DOI":"10.1152\/ajpcell.00130.2002","article-title":"Coordinate modulation of Na\u2013K\u20132Cl cotransport and KCl cotransport by cell volume and chloride","volume":"283","author":"Lytle","year":"2002","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.bbadis.2010.07.009_bb0210","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1152\/physrev.2000.80.1.211","article-title":"Sodium\u2013potassium\u2013chloride cotransport","volume":"80","author":"Russell","year":"2000","journal-title":"Physiol Rev"},{"key":"10.1016\/j.bbadis.2010.07.009_bb0215","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1146\/annurev.physiol.62.1.515","article-title":"The Na\u2013K\u2013Cl cotransporter of secretory epithelia","volume":"62","author":"Haas","year":"2000","journal-title":"Annu Rev Physiol"},{"issue":"2 Pt 1","key":"10.1016\/j.bbadis.2010.07.009_bb0220","doi-asserted-by":"crossref","first-page":"C437","DOI":"10.1152\/ajpcell.1996.270.2.C437","article-title":"Regulatory phosphorylation of the secretory Na\u2013K\u2013Cl cotransporter: modulation by cytoplasmic Cl","volume":"270","author":"Lytle","year":"1996","journal-title":"Am J Physiol"},{"issue":"3","key":"10.1016\/j.bbadis.2010.07.009_bb0225","doi-asserted-by":"crossref","first-page":"C825","DOI":"10.1152\/ajpcell.2001.281.3.C825","article-title":"Direct estimate of 1:1 stoichiometry of K(+)\u2013Cl(\u2212) cotransport in rabbit erythrocytes","volume":"281","author":"Jennings","year":"2001","journal-title":"Am J Physiol Cell Physiol"},{"issue":"5","key":"10.1016\/j.bbadis.2010.07.009_bb0230","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1085\/jgp.98.5.869","article-title":"Coordinated regulation of shrinkageinduced Na\/H exchange and swelling-induced [K\u2013Cl] cotransport in dog red cells. Further evidence from activation kinetics and phosphatase inhibition","volume":"98","author":"Parker","year":"1991","journal-title":"J Gen Physiol"},{"key":"10.1016\/j.bbadis.2010.07.009_bb0235","doi-asserted-by":"crossref","first-page":"15069","DOI":"10.1074\/jbc.272.24.15069","article-title":"Activation of the avian erythrocyte Na\u2013K\u2013Cl cotransport protein by cell shrinkage, cAMP, fluoride, and calyculin-A involves phosphorylation at common sites","volume":"272","author":"Lytle","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bbadis.2010.07.009_bb0240","doi-asserted-by":"crossref","first-page":"C1002","DOI":"10.1152\/ajpcell.1998.274.4.C1002","article-title":"A volume-sensitive protein kinase regulates the Na\u2013K\u20132Cl cotransporter in duck red blood cells","volume":"274","author":"Lytle","year":"1998","journal-title":"Am J Physiol Cell Physiol"},{"issue":"6","key":"10.1016\/j.bbadis.2010.07.009_bb0245","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1172\/JCI30630","article-title":"Disruption of erythroid K\u2013Cl cotransporters alters erythrocyte volume and partially rescues erythrocyte dehydration in SAD mice","volume":"117","author":"Rust","year":"2007","journal-title":"J Clin Invest"},{"issue":"4","key":"10.1016\/j.bbadis.2010.07.009_bb0250","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1358\/dnp.2001.14.4.858404","article-title":"Novel therapies for prevention of erythrocyte dehydration in sickle cell anemia","author":"Brugnara","year":"2001","journal-title":"Drug News Perspect"},{"issue":"1","key":"10.1016\/j.bbadis.2010.07.009_bb0255","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1152\/physrev.00052.2003","article-title":"Ion transport pathology in the mechanism of sickle cell dehydration","volume":"85","author":"Lew","year":"2005","journal-title":"Physiol Rev"},{"issue":"1","key":"10.1016\/j.bbadis.2010.07.009_bb0260","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.nbd.2007.06.014","article-title":"Axonal and periaxonal swelling precede peripheral neurodegeneration in KCC3 knockout mice","volume":"28","author":"Byun","year":"2007","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.bbadis.2010.07.009_bb0265","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0166-2236(03)00068-7","article-title":"Cation-chloride co-transporters in neuronal communication, development and trauma","volume":"26","author":"Payne","year":"2003","journal-title":"Trends Neurosci"},{"issue":"9","key":"10.1016\/j.bbadis.2010.07.009_bb0270","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/ncpneuro0883","article-title":"Roles of the cation-chloride cotransporters in neurological disease","volume":"4","author":"Kahle","year":"2008","journal-title":"Nat Clin Pract Neurol"},{"issue":"6","key":"10.1016\/j.bbadis.2010.07.009_bb0275","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1002\/(SICI)1097-4695(19971120)33:6<781::AID-NEU6>3.0.CO;2-5","article-title":"Expression of the Na\u2013K\u20132Cl cotransporter is developmentally regulated in postnatal rat brains: a possible mechanism underlying GABA's excitatory role in immature brain","volume":"33","author":"Plotkin","year":"1997","journal-title":"J Neurobiol"},{"key":"10.1016\/j.bbadis.2010.07.009_bb0280","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/16697","article-title":"The K+\/Cl\u2212 co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation","volume":"397","author":"Rivera","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2010.07.009_bb0285","first-page":"309","article-title":"Cation-chloride cotransporters in neuronal communication","volume":"15","author":"Delpire","year":"2000","journal-title":"News Physiol Sci"},{"issue":"2","key":"10.1016\/j.bbadis.2010.07.009_bb0290","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/ana.21229","article-title":"Bumetanide enhances phenobarbital efficacy in a neonatal seizure model","volume":"63","author":"Dzhala","year":"2008","journal-title":"Ann Neurol"},{"issue":"9","key":"10.1016\/j.bbadis.2010.07.009_bb0295","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/nrn920","article-title":"Excitatory actions of GABA during development: the nature of the nurture","author":"Ben-Ari","year":"2002","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.bbadis.2010.07.009_bb0300","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/42468","article-title":"GABA in the mammalian suprachiasmatic nucleus and its role in diurnal rhythmicity","volume":"387","author":"Wagner","year":"1997","journal-title":"Nature"},{"issue":"21","key":"10.1016\/j.bbadis.2010.07.009_bb0305","doi-asserted-by":"crossref","first-page":"5450","DOI":"10.1523\/JNEUROSCI.5750-07.2008","article-title":"Excitatory actions of GABA in the suprachiasmatic nucleus","volume":"28","author":"Choi","year":"2008","journal-title":"J Neurosci"},{"issue":"3","key":"10.1016\/j.bbadis.2010.07.009_bb0310","doi-asserted-by":"crossref","first-page":"E22","DOI":"10.3171\/FOC\/2008\/25\/9\/E22","article-title":"The bumetanide-sensitive Na\u2013K\u20132Cl cotransporter NKCC1 as a potential target of a novel mechanism-based treatment strategy for neonatal seizures","volume":"25","author":"Kahle","year":"2008","journal-title":"Neurosurg Focus"},{"issue":"22","key":"10.1016\/j.bbadis.2010.07.009_bb0315","doi-asserted-by":"crossref","first-page":"8465","DOI":"10.1073\/pnas.0602979103","article-title":"Anomalous levels of Cl transporters in the hippocampal subiculum from temporal lobe epilepsy patients make GABA excitatory","volume":"103","author":"Palma","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"issue":"37","key":"10.1016\/j.bbadis.2010.07.009_bb0320","doi-asserted-by":"crossref","first-page":"9866","DOI":"10.1523\/JNEUROSCI.2761-07.2007","article-title":"Perturbed chloride homeostasis and GABAergic signaling in human temporal lobe epilepsy","volume":"27","author":"Huberfeld","year":"2007","journal-title":"J Neurosci"},{"issue":"6951","key":"10.1016\/j.bbadis.2010.07.009_bb0325","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1038\/nature01868","article-title":"Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain","volume":"424","author":"Coull","year":"2003","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.bbadis.2010.07.009_bb0330","first-page":"56","article-title":"The manipulation of cation-chloride co-transporters as a novel means to treat persistent pain, epilepsy and other neurological disorders","volume":"10","author":"Coull","year":"2009","journal-title":"Curr Opin Investig Drugs"},{"issue":"1","key":"10.1016\/j.bbadis.2010.07.009_bb0335","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1083\/jcb.200605093","article-title":"Regulation of 24 activity and localization of the WNK1 protein kinase by hyperosmotic stress","volume":"176","author":"Zag\u00f3rska","year":"2007","journal-title":"J Cell Biol"},{"key":"10.1016\/j.bbadis.2010.07.009_bb0340","doi-asserted-by":"crossref","first-page":"42685","DOI":"10.1074\/jbc.M510042200","article-title":"WNK1 regulates phosphorylation of cation chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1","volume":"280","author":"Moriguchi","year":"2005","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.bbadis.2010.07.009_bb0345","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1042\/BJ20060220","article-title":"Functional interactions of the SPAK\/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1","volume":"397","author":"Vitari","year":"2006","journal-title":"Biochem J"},{"issue":"29","key":"10.1016\/j.bbadis.2010.07.009_bb0350","doi-asserted-by":"crossref","first-page":"10883","DOI":"10.1073\/pnas.0604607103","article-title":"WNK1 and OSR1 regulate the Na+, K+, 2Cl\u2212 cotransporter in HeLa cells","volume":"103","author":"Anselmo","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bbadis.2010.07.009_bb0355","doi-asserted-by":"crossref","first-page":"9157","DOI":"10.1074\/jbc.275.13.9157","article-title":"Proline- and alanine-rich Ste20-related kinase associates with F-actin and translocates from the cytosol to cytoskeleton upon cellular stresses","volume":"275","author":"Tsutsumi","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bbadis.2010.07.009_bb0360","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1006\/abbi.1998.0736","article-title":"Molecular cloning and characterization of a novel Ste20-related protein kinase enriched in neurons and transporting epithelia","volume":"355","author":"Ushiro","year":"1998","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.bbadis.2010.07.009_bb0365","doi-asserted-by":"crossref","first-page":"11129","DOI":"10.1074\/jbc.M313562200","article-title":"Characterization of OSR1, a member of the mammalian Ste20p\/germinal center kinase subfamily","volume":"279","author":"Chen","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bbadis.2010.07.009_bb0370","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1128\/MCB.26.2.689-698.2006","article-title":"Characterization of SPAK and OSR1, regulatory kinases of the Na\u2013K\u20132Cl cotransporter","volume":"26","author":"Gagnon","year":"2006","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.bbadis.2010.07.009_bb0375","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1042\/BJ20051180","article-title":"The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases","volume":"391","author":"Vitari","year":"2005","journal-title":"Biochem J"},{"issue":"1\u20134","key":"10.1016\/j.bbadis.2010.07.009_bb0380","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1159\/000104161","article-title":"A single binding motif is required for SPAK activation of the Na\u2013K\u20132Cl cotransporter","volume":"20","author":"Gagnon","year":"2007","journal-title":"Cell Physiol Biochem"},{"issue":"24","key":"10.1016\/j.bbadis.2010.07.009_bb0385","doi-asserted-by":"crossref","first-page":"8458","DOI":"10.1073\/pnas.0802966105","article-title":"Regulation of NKCC2 by a chloride-sensing mechanism 25 involving the WNK3 and SPAK kinases","volume":"105","author":"Ponce-Coria","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"issue":"9","key":"10.1016\/j.bbadis.2010.07.009_bb0390","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/sj.embor.7401048","article-title":"Structural insights into the recognition of substrates and activators by the OSR1 kinase","volume":"8","author":"Villa","year":"2007","journal-title":"EMBO Rep"},{"issue":"2","key":"10.1016\/j.bbadis.2010.07.009_bb0395","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1152\/physiolgenomics.00173.2006","article-title":"Genome-wide analysis of SPAK\/OSR1 binding motifs","volume":"28","author":"Delpire","year":"2007","journal-title":"Physiol Genomics"},{"issue":"2","key":"10.1016\/j.bbadis.2010.07.009_bb0400","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/emmm.200900058","article-title":"Role of the WNK-activated SPAK kinase in regulating blood pressure","volume":"2","author":"Rafiqi","year":"2010","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.bbadis.2010.07.009_bb0405","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M110.112672","article-title":"Multiple pathways for PP1 regulation of NKCC1 function: the N-terminal tail of the Na\u2013K\u20132Cl cotransporter serves as a regulatory scaffold for SPAK and PP1","author":"Gagnon","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bbadis.2010.07.009_bb0410","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1073\/pnas.0510947103","article-title":"WNK3 bypasses the tonicity requirement for K\u2013Cl cotransporter activation via a phosphatase-dependent pathway","volume":"103","author":"de Los Heros","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"10.1016\/j.bbadis.2010.07.009_bb0415","doi-asserted-by":"crossref","first-page":"F1197","DOI":"10.1152\/ajprenal.00335.2006","article-title":"WNK4 kinase is a negative regulator of K+\u2013Cl cotransporters","volume":"292","author":"Garz\u00f3n-Muvdi","year":"2007","journal-title":"Am J Physiol Ren Physiol"},{"issue":"3","key":"10.1016\/j.bbadis.2010.07.009_bb0420","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.cell.2009.05.031","article-title":"Sites of regulated phosphorylation that control K\u2013Cl cotransporter activity","volume":"138","author":"Rinehart","year":"2009","journal-title":"Cell"},{"issue":"19","key":"10.1016\/j.bbadis.2010.07.009_bb0425","doi-asserted-by":"crossref","first-page":"4683","DOI":"10.1523\/JNEUROSCI.5265-03.2004","article-title":"Mechanism of activity-dependent downregulation of the neuron-specific K\u2013Cl cotransporter KCC2","volume":"24","author":"Rivera","year":"2004","journal-title":"J Neurosci"},{"issue":"335","key":"10.1016\/j.bbadis.2010.07.009_bb0430","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.gene.2004.03.009","article-title":"Cloning, genomic organization, alternative splicing and expression analysis of the human gene WNK3 (PRKWNK3)","volume":"23","author":"Holden","year":"2004","journal-title":"Gene"},{"issue":"4","key":"10.1016\/j.bbadis.2010.07.009_bb0435","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1016\/j.neuroscience.2009.11.040","article-title":"Cell-type specific distribution of chloride transporters in the rat suprachiasmatic nucleus","volume":"165","author":"Belenky","year":"2010","journal-title":"Neuroscience"},{"issue":"2","key":"10.1016\/j.bbadis.2010.07.009_bb0440","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1085\/jgp.200409215","article-title":"GCK-3, a newly identified Ste20 kinase, binds to and regulates the activity of a cell cycle-dependent ClC anion channel","volume":"125","author":"Denton","year":"2005","journal-title":"J Gen Physiol"},{"issue":"9","key":"10.1016\/j.bbadis.2010.07.009_bb0445","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/ng0909-954","article-title":"CLCN2 variants in idiopathic generalized epilepsy","volume":"41","author":"Kleefuss-Lie","year":"2009","journal-title":"Nat Genet"},{"issue":"1","key":"10.1016\/j.bbadis.2010.07.009_bb0450","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/sj.embor.7401128","article-title":"Caenorhabditis elegans WNK-STE20 pathway regulates tube formation by modulating ClC channel activity","volume":"9","author":"Hisamoto","year":"2008","journal-title":"EMBO Rep"},{"key":"10.1016\/j.bbadis.2010.07.009_bb0455","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1152\/physiol.00139.2005","article-title":"Ste20-type kinases: evolutionarily conserved regulators of ion transport and cell volume","volume":"21","author":"Strange","year":"2006","journal-title":"Physiology Bethesda"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443910001468?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443910001468?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T00:11:07Z","timestamp":1559261467000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443910001468"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":91,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S0925443910001468"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2010.07.009","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]}}}