{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T08:20:04Z","timestamp":1770970804097,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":874,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["30700382"],"award-info":[{"award-number":["30700382"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Education Commission of Shanghai","award":["06BZ024"],"award-info":[{"award-number":["06BZ024"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1016\/j.bbadis.2010.10.001","type":"journal-article","created":{"date-parts":[[2010,10,21]],"date-time":"2010-10-21T09:35:49Z","timestamp":1287653749000},"page":"527-535","source":"Crossref","is-referenced-by-count":39,"title":["Berberine attenuates cAMP-induced lipolysis via reducing the inhibition of phosphodiesterase in 3T3-L1 adipocytes"],"prefix":"10.1016","volume":"1812","author":[{"given":"Libin","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengying","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoyue","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingdao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang","family":"Ning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Suppl 3","key":"10.1016\/j.bbadis.2010.10.001_bb0005","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1046\/j.1365-2362.32.s3.5.x","article-title":"The evolution of beta-cell dysfunction and insulin resistance in type 2 diabetes","volume":"32","author":"Bergman","year":"2002","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2010.10.001_bb0010","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1046\/j.1525-1381.1999.99220.x","article-title":"Free fatty acids, insulin resistance and type 2 diabetes mellitus","volume":"111","author":"Boden","year":"1999","journal-title":"Proc. Ass. Am. Physicians"},{"key":"10.1016\/j.bbadis.2010.10.001_bb0015","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s00125-002-0873-y","article-title":"Adipose tissue as a buffer for daily lipid flux","volume":"45","author":"Frayn","year":"2002","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbadis.2010.10.001_bb0020","doi-asserted-by":"crossref","first-page":"863","DOI":"10.2337\/diab.44.8.863","article-title":"Lipotoxicity in the pathogenesis of obesity-dependent NIDDM: genetic and clinical implications","volume":"44","author":"Unger","year":"1995","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2010.10.001_bb0025","doi-asserted-by":"crossref","first-page":"7522","DOI":"10.1073\/pnas.121164498","article-title":"Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance","volume":"98","author":"Kim","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bbadis.2010.10.001_bb0030","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1073\/pnas.95.5.2498","article-title":"Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes","volume":"95","author":"Shimabukuro","year":"1998","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.bbadis.2010.10.001_bb0035","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1124\/jpet.105.086926","article-title":"Specific inhibition of hormone-sensitive lipase improves lipid profile while reducing plasma glucose","volume":"315","author":"Claus","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbadis.2010.10.001_bb0040","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1042\/bst0311120","article-title":"Molecular mechanisms regulating hormone-sensitive lipase and lipolysis","volume":"31","author":"Holm","year":"2003","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.bbadis.2010.10.001_bb0045","doi-asserted-by":"crossref","first-page":"5011","DOI":"10.1074\/jbc.275.7.5011","article-title":"Translocation of hormone-sensitive lipase and perilipin upon lipolytic stimulation of rat adipocytes","volume":"275","author":"Clifford","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2010.10.001_bb0050","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.2337\/diabetes.48.9.1691","article-title":"Long-term regulation of lipolysis and hormone-sensitive lipase by insulin and glucose","volume":"48","author":"Botion","year":"1999","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2010.10.001_bb0055","first-page":"401","article-title":"Studies on the hypoglycemic effect of Coptis chinensis and berberine","volume":"21","author":"Chen","year":"1986","journal-title":"Yao Xue Xue Bao"},{"key":"10.1016\/j.bbadis.2010.10.001_bb0060","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1210\/jc.2007-2404","article-title":"Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine","volume":"93","author":"Zhang","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbadis.2010.10.001_bb0065","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.2337\/db06-0006","article-title":"Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states","volume":"55","author":"Lee","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2010.10.001_bb0070","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.2337\/db07-1552","article-title":"Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action","volume":"57","author":"Turner","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2010.10.001_bb0075","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1038\/nm1135","article-title":"Berberine is a novel cholesterol lowering drug working through a unique mechanism distinct from statins","volume":"10","author":"Kong","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbadis.2010.10.001_bb0080","doi-asserted-by":"crossref","first-page":"4510","DOI":"10.1210\/en.2007-1752","article-title":"Berberine acutely inhibits insulin secretion from beta cells through cAMP signaling pathway","volume":"149","author":"Zhou","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbadis.2010.10.001_bb0085","first-page":"496","article-title":"Therapeutic effects of berberine in impaired glucose tolerance rats and its influence on insulin secretion","volume":"25","author":"Leng","year":"2004","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.bbadis.2010.10.001_bb0090","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1073\/pnas.77.1.285","article-title":"Insulin receptor synthesis and turnover in differentiating 3T3-L1 preadipocytes","volume":"77","author":"Reed","year":"1980","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.bbadis.2010.10.001_bb0095","doi-asserted-by":"crossref","first-page":"74","DOI":"10.2337\/diabetes.53.1.74","article-title":"Stimulation of lipolysis by tumor necrosis factor-alpha in 3T3-L1 adipocytes is glucose dependent: implications for long-term regulation of lipolysis","volume":"53","author":"Green","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2010.10.001_bb0100","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1110\/ps.6601","article-title":"Identification of overlapping but distinct cAMP and cGMP interaction sites with cyclic nucleotide phosphodiesterase 3A by site-directed mutagenesis and molecular modeling based on crystalline PDE4B","volume":"10","author":"Zhang","year":"2001","journal-title":"Protein Sci."},{"key":"10.1016\/j.bbadis.2010.10.001_bb0105","doi-asserted-by":"crossref","first-page":"45456","DOI":"10.1074\/jbc.M104436200","article-title":"Stimulation of lipolysis and hormone-sensitive lipase via the extracellular signal-regulated kinase pathway","volume":"276","author":"Greenberg","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2010.10.001_bb0110","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1210\/endo.138.6.5158","article-title":"Antilipolytic actions of vanadate and insulin in rat adipocytes mediated by distinctly different mechanisms","volume":"138","author":"Li","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbadis.2010.10.001_bb0115","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.metabol.2006.10.025","article-title":"Berberine stimulates glucose transport through a mechanism distinct from insulin","volume":"56","author":"Zhou","year":"2007","journal-title":"Metabolism"},{"key":"10.1016\/j.bbadis.2010.10.001_bb0120","doi-asserted-by":"crossref","first-page":"3568","DOI":"10.1016\/S0021-9258(17)41901-6","article-title":"Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes","volume":"269","author":"Okada","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2010.10.001_bb0125","doi-asserted-by":"crossref","first-page":"25250","DOI":"10.1074\/jbc.M414222200","article-title":"Anti-lipolytic action of AMP-activated protein kinase in rodent adipocytes","volume":"280","author":"Daval","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2010.10.001_bb0130","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1194\/jlr.M600020-JLR200","article-title":"Inhibition of lipid synthesis through activation of AMP-kinase: an additional mechanism for the hypolipidemic effects of berberine","volume":"47","author":"Brusq","year":"2006","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbadis.2010.10.001_bb0135","doi-asserted-by":"crossref","first-page":"43074","DOI":"10.1074\/jbc.M308484200","article-title":"Role of AMP-activated protein kinase in cyclic AMP-dependent lipolysis In 3T3-L1 adipocytes","volume":"278","author":"Yin","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2010.10.001_bb0140","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1432-1033.1989.tb14548.x","article-title":"Phosphorylation of bovine hormone-sensitive lipase by the AMP-activated protein kinase. A possible antilipolytic mechanism","volume":"179","author":"Garton","year":"1989","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.bbadis.2010.10.001_bb0145","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1172\/JCI114142","article-title":"Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance","volume":"84","author":"Groop","year":"1989","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2010.10.001_bb0150","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0079-6603(00)66031-2","article-title":"Regulation and function of the cyclic nucleotide phosphodiesterase (PDE3) gene family","volume":"66","author":"Shakur","year":"2001","journal-title":"Prog. Nucleic Acid Res. Mol. Biol."},{"key":"10.1016\/j.bbadis.2010.10.001_bb0155","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1096\/fj.01-0278fje","article-title":"Mechanism of intracellular calcium ([Ca2+]i) inhibition of lipolysis in human adipocytes","volume":"15","author":"Xue","year":"2001","journal-title":"FASEB J."},{"key":"10.1016\/j.bbadis.2010.10.001_bb0160","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1194\/jlr.M400362-JLR200","article-title":"The role of cyclic nucleotide phosphodiesterases in the regulation of adipocyte lipolysis","volume":"46","author":"Snyder","year":"2005","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbadis.2010.10.001_bb0165","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/0026-0495(95)90135-3","article-title":"Regulation of hormone-sensitive lipase in streptozotocin-induced diabetic rats","volume":"44","author":"Sztalryd","year":"1995","journal-title":"Metabolism"},{"key":"10.1016\/j.bbadis.2010.10.001_bb0170","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1074\/jbc.273.1.215","article-title":"Identification of novel phosphorylation sites in hormone-sensitive lipase that are phosphorylated in response to isoproterenol and govern activation properties in vitro","volume":"273","author":"Anthonsen","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2010.10.001_bb0175","doi-asserted-by":"crossref","first-page":"16514","DOI":"10.1074\/jbc.M708177200","article-title":"AMP-activated protein kinase is activated as a consequence of lipolysis in the adipocyte: potential mechanism and physiological relevance","volume":"283","author":"Gauthier","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2010.10.001_bb0180","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.cellsig.2009.01.015","article-title":"Regulation of AMP-activated protein kinase by cAMP in adipocytes: roles for phosphodiesterases, protein kinase B, protein kinase A, Epac and lipolysis","volume":"21","author":"Omar","year":"2009","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbadis.2010.10.001_bb0185","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.bbrc.2006.11.032","article-title":"Palmitate activates AMP-activated protein kinase and regulates insulin secretion from beta cells","volume":"352","author":"Wang","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbadis.2010.10.001_bb0190","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.cellsig.2005.08.009","article-title":"Signalling mechanisms regulating lipolysis","volume":"18","author":"Carmen","year":"2006","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbadis.2010.10.001_bb0195","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0092-8674(00)80184-1","article-title":"cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway","volume":"89","author":"Vossler","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2010.10.001_bb0200","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0167-4889(96)00130-9","article-title":"8-Bromo-cAMP induces a proliferative response in an IL-3 dependent leukemic cell line and activates Erk 1, 2 via a Shc-independent pathway","volume":"1355","author":"Barge","year":"1997","journal-title":"Biochim. Biophys. Acta"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443910002188?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443910002188?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T10:40:13Z","timestamp":1636713613000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443910002188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["S0925443910002188"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2010.10.001","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2011,4]]}}}