{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:48:00Z","timestamp":1792784880818,"version":"4.5.0"},"reference-count":209,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,18]],"date-time":"2013-07-18T00:00:00Z","timestamp":1374105600000},"content-version":"vor","delay-in-days":656,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"crossref","award":["SDG 0730111N"],"award-info":[{"award-number":["SDG 0730111N"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100001463","name":"American Society of Nephrology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100001463","id-type":"DOI","asserted-by":"crossref"}]},{"name":"American Society of Physiology S&R Foundation Ryuji Ueno Award","id":[{"id":"https:\/\/ror.org\/05022hb90","id-type":"ROR","asserted-by":"crossref"}]},{"name":"NIH","award":["DK62345"],"award-info":[{"award-number":["DK62345"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1016\/j.bbadis.2010.10.004","type":"journal-article","created":{"date-parts":[[2010,10,17]],"date-time":"2010-10-17T04:27:12Z","timestamp":1287289632000},"page":"1301-1313","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"title":["Epidermal growth factor-mediated proliferation and sodium transport in normal and PKD epithelial cells"],"prefix":"10.1016","volume":"1812","author":[{"given":"Nadezhda N.","family":"Zheleznova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia D.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Staruschenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2010.10.004_bb0005","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1056\/NEJMoa054341","article-title":"Volume progression in polycystic kidney disease","volume":"354","author":"Grantham","year":"2006","journal-title":"N Engl J. Med."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0010","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1097\/MNH.0b013e3283262ab0","article-title":"Advances in the pathogenesis and treatment of polycystic kidney disease","volume":"18","author":"Patel","year":"2009","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0015","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/S0962-8924(03)00169-7","article-title":"Role of polycystins in renal tubulogenesis","volume":"13","author":"Boletta","year":"2003","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0020","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev.med.60.101707.125712","article-title":"Polycystic kidney disease","volume":"60","author":"Harris","year":"2009","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0025","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/ki.2009.128","article-title":"Autosomal dominant polycystic kidney disease: the last 3years","volume":"76","author":"Torres","year":"2009","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0030","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1056\/NEJMra022161","article-title":"Polycystic kidney disease","volume":"350","author":"Wilson","year":"2004","journal-title":"N Engl J. Med."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0035","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/S0140-6736(07)60601-1","article-title":"Autosomal dominant polycystic kidney disease","volume":"369","author":"Torres","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.bbadis.2010.10.004_bb0040","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0070-2153(08)00606-6","article-title":"Mouse models of polycystic kidney disease","volume":"84","author":"Wilson","year":"2008","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0045","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1681\/ASN.2008010033","article-title":"ARPKD and ADPKD: first cousins or more distant relatives?","volume":"19","author":"Kaimori","year":"2008","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0050","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1152\/physrev.1998.78.4.1165","article-title":"Epithelial transport in polycystic kidney disease","volume":"78","author":"Sullivan","year":"1998","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0055","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1146\/annurev.pathol.2.010506.091850","article-title":"Cystic disease of the kidney","volume":"2","author":"Wilson","year":"2007","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0060","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1161\/HYPERTENSIONAHA.108.113860","article-title":"G.H. van, Epidermal growth factor receptor signaling in the kidney: key roles in physiology and disease","volume":"52","author":"Melenhorst","year":"2008","journal-title":"Hypertension"},{"key":"10.1016\/j.bbadis.2010.10.004_bb0065","doi-asserted-by":"crossref","first-page":"C487","DOI":"10.1152\/ajpcell.1995.269.2.C487","article-title":"Abnormal polarization of EGF receptors and autocrine stimulation of cyst epithelial growth in human ADPKD","volume":"269","author":"Du","year":"1995","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0070","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S0092-8674(02)00966-2","article-title":"Ligand-induced, receptor-mediated dimerization and activation of EGF receptor","volume":"110","author":"Schlessinger","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2010.10.004_bb0075","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/276409a0","article-title":"Epidermal growth factor stimulates phosphorylation in membrane preparations in vitro","volume":"276","author":"Carpenter","year":"1978","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2010.10.004_bb0080","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0092-8674(00)00114-8","article-title":"Cell signaling by receptor tyrosine kinases","volume":"103","author":"Schlessinger","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2010.10.004_bb0085","doi-asserted-by":"crossref","first-page":"9567","DOI":"10.1073\/pnas.85.24.9567","article-title":"Ligand-induced stimulation of epidermal growth factor receptor mutants with altered transmembrane regions","volume":"85","author":"Kashles","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0090","doi-asserted-by":"crossref","first-page":"7709","DOI":"10.1016\/S0021-9258(19)38983-5","article-title":"Epidermal growth factor","volume":"265","author":"Carpenter","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0095","doi-asserted-by":"crossref","first-page":"32031","DOI":"10.1016\/S0021-9258(18)31593-X","article-title":"A region in Shc distinct from the SH2 domain can bind tyrosine-phosphorylated growth factor receptors","volume":"269","author":"Blaikie","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0100","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1146\/annurev.pharmtox.44.101802.121440","article-title":"ErbB receptors: directing key signaling networks throughout life","volume":"44","author":"Holbro","year":"2004","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0105","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.yexcr.2008.08.005","article-title":"The role of the EGF family of ligands and receptors in renal development, physiology and pathophysiology","volume":"315","author":"Zeng","year":"2009","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0110","doi-asserted-by":"crossref","first-page":"4446","DOI":"10.1091\/mbc.e07-03-0223","article-title":"ErbB4 isoforms selectively regulate growth factor induced Madin-Darby canine kidney cell tubulogenesis","volume":"18","author":"Zeng","year":"2007","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbadis.2010.10.004_bb0115","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1002\/jcp.22033","article-title":"EGF and its related growth factors mediate sodium transport in mpkCCD(c14) cells via ErbB2 (neu\/HER-2) receptor","volume":"223","author":"Levchenko","year":"2010","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0120","first-page":"953","article-title":"Expression of the HER-2\/neu proto-oncogene in normal human adult and fetal tissues","volume":"5","author":"Press","year":"1990","journal-title":"Oncogene"},{"key":"10.1016\/j.bbadis.2010.10.004_bb0125","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1681\/ASN.2009080885","article-title":"Endothelin-1 inhibits the epithelial Na+channel through betaPix\/14-3-3\/Nedd4-2","volume":"21","author":"Pavlov","year":"2010","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0130","doi-asserted-by":"crossref","first-page":"32901","DOI":"10.1074\/jbc.272.52.32901","article-title":"The cytoplasmic juxtamembrane domain of the epidermal growth factor receptor contains a novel autonomous basolateral sorting determinant","volume":"272","author":"Hobert","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0135","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1002\/(SICI)1097-4652(199911)181:2<330::AID-JCP15>3.0.CO;2-S","article-title":"Regulation of EGF signaling by cell polarity in MDCK kidney epithelial cells","volume":"181","author":"Hobert","year":"1999","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0140","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S0014-4827(02)00105-2","article-title":"EGF receptor ligands","volume":"284","author":"Harris","year":"2003","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0145","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/j.cellsig.2005.03.026","article-title":"Autocrine, paracrine and juxtacrine signaling by EGFR ligands","volume":"17","author":"Singh","year":"2005","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0150","first-page":"85","article-title":"Roles for growth factors in cancer progression","volume":"25","author":"Witsch","year":"2010","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.bbadis.2010.10.004_bb0155","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.yexcr.2008.10.034","article-title":"ErbB receptors and cell polarity: new pathways and paradigms for understanding cell migration and invasion","volume":"315","author":"Feigin","year":"2009","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0160","doi-asserted-by":"crossref","first-page":"5276","DOI":"10.1128\/MCB.16.10.5276","article-title":"A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor\/neuregulin and epidermal growth factor","volume":"16","author":"Tzahar","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0165","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1093\/emboj\/16.7.1647","article-title":"ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling","volume":"16","author":"Graus-Porta","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0170","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S0014-4827(02)00101-5","article-title":"The deaf and the dumb: the biology of ErbB-2 and ErbB-3","volume":"284","author":"Citri","year":"2003","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0175","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.febslet.2004.06.014","article-title":"ErbB3\/HER3 does not homodimerize upon neuregulin binding at the cell surface","volume":"569","author":"Berger","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0180","doi-asserted-by":"crossref","first-page":"7692","DOI":"10.1073\/pnas.1002753107","article-title":"ErbB3\/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation","volume":"107","author":"Shi","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0185","doi-asserted-by":"crossref","first-page":"F781","DOI":"10.1152\/ajprenal.90610.2008","article-title":"ADAM17 upregulation in human renal disease: a role in modulating TGF-{alpha} availability?","volume":"297","author":"Melenhorst","year":"2009","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0190","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.yexcr.2008.10.011","article-title":"The role of protease activity in ErbB biology","volume":"315","author":"Blobel","year":"2009","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0195","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1080\/08977190600634373","article-title":"Control of ErbB signaling through metalloprotease mediated ectodomain shedding of EGF-like factors","volume":"24","author":"Sanderson","year":"2006","journal-title":"Growth Factors"},{"key":"10.1016\/j.bbadis.2010.10.004_bb0200","doi-asserted-by":"crossref","first-page":"C1","DOI":"10.1152\/ajpcell.00620.2005","article-title":"ADAMs as mediators of EGF receptor transactivation by G protein-coupled receptors","volume":"291","author":"Ohtsu","year":"2006","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0205","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/nm1275","article-title":"Angiotensin II and EGF receptor cross-talk in chronic kidney diseases: a new therapeutic approach","volume":"11","author":"Lautrette","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0210","doi-asserted-by":"crossref","DOI":"10.1124\/mol.110.064840","article-title":"Bradykinin B2 Receptor interacts with integrin alpha5beta1 to transactivate epidermal growth factor receptor in kidney cells","author":"Kramarenko","year":"2010","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0215","doi-asserted-by":"crossref","first-page":"31730","DOI":"10.1074\/jbc.272.50.31730","article-title":"Matrix metalloproteinase-3 releases active heparin-binding EGF-like growth factor by cleavage at a specific juxtamembrane site","volume":"272","author":"Suzuki","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0220","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1161\/01.RES.0000070112.80711.3D","article-title":"Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry","volume":"92","author":"Visse","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0225","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1681\/ASN.2009030312","article-title":"MMP9 limits apoptosis and stimulates branching morphogenesis during kidney development","volume":"20","author":"Arnould","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0230","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1742-4658.2009.07448.x","article-title":"Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer","volume":"277","author":"Mitsudomi","year":"2010","journal-title":"FEBS J."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0235","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/35077225","article-title":"Oncogenic kinase signalling","volume":"411","author":"Blume-Jensen","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2010.10.004_bb0240","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/ki.1996.94","article-title":"Expression of epidermal growth factor and its receptor in normal and diseased human kidney: an immunohistochemical and in situ hybridization study","volume":"49","author":"Gesualdo","year":"1996","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0245","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1111\/j.1523-1755.2004.00667.x","article-title":"A plethora of epidermal growth factor-like proteins in polycystic kidneys","volume":"65","author":"Wilson","year":"2004","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0250","doi-asserted-by":"crossref","first-page":"F828","DOI":"10.1152\/ajprenal.00369.2006","article-title":"Control of tight junctional sealing: role of epidermal growth factor","volume":"292","author":"Flores-Benitez","year":"2007","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0255","doi-asserted-by":"crossref","first-page":"C611","DOI":"10.1152\/ajpcell.00622.2008","article-title":"Control of tight junctional sealing: roles of epidermal growth factor and prostaglandin E2","volume":"297","author":"Flores-Benitez","year":"2009","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0260","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1749-6632.2009.04439.x","article-title":"Tight junction proteins as channel formers and barrier builders","volume":"1165","author":"Amasheh","year":"2009","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0265","doi-asserted-by":"crossref","first-page":"C1660","DOI":"10.1152\/ajpcell.00274.2007","article-title":"Juxtacrine activation of EGFR regulates claudin expression and increases transepithelial resistance","volume":"293","author":"Singh","year":"2007","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0270","doi-asserted-by":"crossref","first-page":"F957","DOI":"10.1152\/ajprenal.90490.2008","article-title":"Soluble HB-EGF induces epithelial-to-mesenchymal transition in inner medullary collecting duct cells by upregulating Snail-2","volume":"296","author":"Smith","year":"2009","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0275","doi-asserted-by":"crossref","first-page":"6845","DOI":"10.1128\/MCB.19.10.6845","article-title":"Controlled dimerization of ErbB receptors provides evidence for differential signaling by homo- and heterodimers","volume":"19","author":"Muthuswamy","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0280","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1538\/expanim.49.51","article-title":"Characterization of a novel polycystic kidney rat model with accompanying polycystic liver","volume":"49","author":"Katsuyama","year":"2000","journal-title":"Exp. Anim."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0285","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1681\/ASN.2009010014","article-title":"Homer W. Smith Award: insights into the pathogenesis of polycystic kidney disease from gene discovery","volume":"20","author":"Harris","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0290","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1016\/j.biocel.2004.03.012","article-title":"Polycystic kidney disease: new understanding in the pathogenesis","volume":"36","author":"Wilson","year":"2004","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0295","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/ncpneph0070","article-title":"Mechanisms of Disease: autosomal dominant and recessive polycystic kidney diseases","volume":"2","author":"Torres","year":"2006","journal-title":"Nat. Clin. Pract. Nephrol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0300","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1056\/NEJM199307293290508","article-title":"Autosomal dominant polycystic kidney disease","volume":"329","author":"Gabow","year":"1993","journal-title":"N Engl J. Med."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0305","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/ng0695-151","article-title":"The polycystic kidney disease 1 (PKD1) gene encodes a novel protein with multiple cell recognition domains","volume":"10","author":"Hughes","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0310","doi-asserted-by":"crossref","first-page":"20763","DOI":"10.1074\/jbc.M107788200","article-title":"Identification, characterization, and localization of a novel kidney polycystin-1-polycystin-2 complex","volume":"277","author":"Newby","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0315","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1038\/35050128","article-title":"Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents","volume":"408","author":"Hanaoka","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2010.10.004_bb0320","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1093\/hmg\/9.11.1641","article-title":"Strong homophilic interactions of the Ig-like domains of polycystin-1, the protein product of an autosomal dominant polycystic kidney disease gene, PKD1","volume":"9","author":"Ibraghimov-Beskrovnaya","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0325","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0925-4439(00)00079-X","article-title":"Modification of the composition of polycystin-1 multiprotein complexes by calcium and tyrosine phosphorylation","volume":"1535","author":"Geng","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2010.10.004_bb0330","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1073\/pnas.93.4.1524","article-title":"Polycystin, the polycystic kidney disease 1 protein, is expressed by epithelial cells in fetal, adult, and polycystic kidney","volume":"93","author":"Ward","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0335","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1681\/ASN.2005060645","article-title":"Calcium Restores a Normal Proliferation Phenotype in Human Polycystic Kidney Disease Epithelial Cells","volume":"17","author":"Yamaguchi","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0340","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1038\/nm1783","article-title":"A tumor necrosis factor-alpha-mediated pathway promoting autosomal dominant polycystic kidney disease","volume":"14","author":"Li","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0345","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0092-8674(02)00716-X","article-title":"PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2","volume":"109","author":"Bhunia","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2010.10.004_bb0350","doi-asserted-by":"crossref","first-page":"6965","DOI":"10.1073\/pnas.94.13.6965","article-title":"Homo- and heterodimeric interactions between the gene products of PKD1 and PKD2","volume":"94","author":"Tsiokas","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0355","doi-asserted-by":"crossref","first-page":"3934","DOI":"10.1073\/pnas.96.7.3934","article-title":"Specific association of the gene product of PKD2 with the TRPC1 channel","volume":"96","author":"Tsiokas","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0360","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/ng1076","article-title":"Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells","volume":"33","author":"Nauli","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0365","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/ng0697-179","article-title":"PKD1 interacts with PKD2 through a probable coiled-coil domain","volume":"16","author":"Qian","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0370","doi-asserted-by":"crossref","first-page":"25582","DOI":"10.1074\/jbc.M402829200","article-title":"The N-terminal extracellular domain is required for polycystin-1-dependent channel activity","volume":"279","author":"Babich","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0375","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1096\/fj.03-0319fje","article-title":"Gating of the polycystin ion channel signaling complex in neurons and kidney cells","volume":"18","author":"Delmas","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0380","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.cell.2009.08.045","article-title":"Polycystin-1 and -2 dosage regulates pressure sensing","volume":"139","author":"Sharif-Naeini","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2010.10.004_bb0385","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1038\/emboj.2010.18","article-title":"A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes","volume":"29","author":"Giamarchi","year":"2010","journal-title":"EMBO J."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0390","doi-asserted-by":"crossref","first-page":"11558","DOI":"10.1073\/pnas.0903684106","article-title":"Structural and molecular basis of the assembly of the TRPP2\/PKD1 complex","volume":"106","author":"Yu","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0395","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/nrneph.2009.100","article-title":"The role of transient receptor potential channels in kidney disease","volume":"5","author":"Woudenberg-Vrenken","year":"2009","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0400","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1113\/jphysiol.2006.119024","article-title":"TRPpathies","volume":"578","author":"Kiselyov","year":"2007","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0405","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1146\/annurev.physiol.70.113006.100621","article-title":"Polycystins and primary cilia: primers for cell cycle progression","volume":"71","author":"Zhou","year":"2009","journal-title":"Anu. Rev. Physiol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0410","doi-asserted-by":"crossref","first-page":"F1","DOI":"10.1152\/ajprenal.90277.2008","article-title":"Function and regulation of TRPP2 at the plasma membrane","volume":"297","author":"Tsiokas","year":"2009","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0415","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1126\/science.272.5266.1339","article-title":"PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein","volume":"272","author":"Mochizuki","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2010.10.004_bb0420","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1083\/jcb.200805124","article-title":"TRPP2 and TRPV4 form a polymodal sensory channel complex","volume":"182","author":"Kottgen","year":"2008","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0425","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/embor.2008.29","article-title":"Formation of a new receptor-operated channel by heteromeric assembly of TRPP2 and TRPC1 subunits","volume":"9","author":"Bai","year":"2008","journal-title":"EMBO Rep."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0430","doi-asserted-by":"crossref","first-page":"35507","DOI":"10.1074\/jbc.M109.060228","article-title":"The transient receptor potential channels TRPP2 and TRPC1 form a heterotetramer with a 2:2 stoichiometry and an alternating subunit arrangement","volume":"284","author":"Kobori","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0435","doi-asserted-by":"crossref","first-page":"15167","DOI":"10.1074\/jbc.M110.106153","article-title":"Contribution of TRPV1-TRPA1 interaction to the single channel properties of the TRPA1 channel","volume":"285","author":"Staruschenko","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0440","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1086\/340448","article-title":"PKHD1, the polycystic kidney and hepatic disease 1 gene, encodes a novel large protein containing multiple immunoglobulin-like plexin-transcription-factor domains and parallel beta-helix 1 repeats","volume":"70","author":"Onuchic","year":"2002","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0445","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/ng833","article-title":"The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein","volume":"30","author":"Ward","year":"2002","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0450","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1097\/01.ASN.0000030392.19694.9D","article-title":"Identification and characterization of Pkhd1, the mouse orthologue of the human ARPKD gene","volume":"13","author":"Nagasawa","year":"2002","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0455","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1093\/hmg\/ddg068","article-title":"PKHDL1, a homolog of the autosomal recessive polycystic kidney disease gene, encodes a receptor with inducible T lymphocyte expression","volume":"12","author":"Hogan","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0460","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1111\/j.1523-1755.2004.00844.x","article-title":"Polyductin, the PKHD1 gene product, comprises isoforms expressed in plasma membrane, primary cilium, and cytoplasm","volume":"66","author":"Menezes","year":"2004","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0465","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1097\/01.ASN.0000113793.12558.1D","article-title":"The autosomal recessive polycystic kidney disease protein is localized to primary cilia, with concentration in the basal body area","volume":"15","author":"Wang","year":"2004","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0470","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1093\/hmg\/ddg274","article-title":"Cellular and subcellular localization of the ARPKD protein; fibrocystin is expressed on primary cilia","volume":"12","author":"Ward","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0475","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1073\/pnas.0400073101","article-title":"PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cells","volume":"101","author":"Zhang","year":"2004","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.bbadis.2010.10.004_bb0480","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1681\/ASN.2007070770","article-title":"Fibrocystin\/polyductin modulates renal tubular formation by regulating polycystin-2 expression and function","volume":"19","author":"Kim","year":"2008","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0485","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.1128\/MCB.00072-07","article-title":"Fibrocystin\/polyductin, found in the same protein complex with polycystin-2, regulates calcium responses in kidney epithelia","volume":"27","author":"Wang","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0490","doi-asserted-by":"crossref","first-page":"C831","DOI":"10.1152\/ajpcell.00032.2009","article-title":"Abnormalities in focal adhesion complex formation, regulation, and function in human autosomal recessive polycystic kidney disease epithelial cells","volume":"298","author":"Israeli","year":"2010","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0495","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1046\/j.1523-1755.2000.00829.x","article-title":"Treatment of polycystic kidney disease with a novel tyrosine kinase inhibitor","volume":"57","author":"Sweeney","year":"2000","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0500","first-page":"F387","article-title":"Functional activity of epidermal growth factor receptors in autosomal recessive polycystic kidney disease","volume":"275","author":"Sweeney","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0505","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1007\/s00441-006-0226-0","article-title":"Molecular and cellular pathophysiology of autosomal recessive polycystic kidney disease (ARPKD)","volume":"326","author":"Sweeney","year":"2006","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0510","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1681\/ASN.V122379","article-title":"Segment-specific c-ErbB2 expression in human autosomal recessive polycystic kidney disease","volume":"12","author":"Nakanishi","year":"2001","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0515","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1111\/j.1523-1755.2004.00952.x","article-title":"Epidermal growth factor receptor tyrosine kinase inhibition is not protective in PCK rats","volume":"66","author":"Torres","year":"2004","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0520","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1681\/ASN.2007060665","article-title":"Src inhibition ameliorates polycystic kidney disease","volume":"19","author":"Sweeney","year":"2008","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0525","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/nrm1962","article-title":"EGF-ERBB signalling: towards the systems level","volume":"7","author":"Citri","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0530","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1126\/science.1105396","article-title":"Common and distinct elements in cellular signaling via EGF and FGF receptors","volume":"306","author":"Schlessinger","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2010.10.004_bb0535","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S0014-5793(01)02117-2","article-title":"Molecular mechanisms underlying endocytosis and sorting of ErbB receptor tyrosine kinases","volume":"490","author":"Waterman","year":"2001","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0540","first-page":"131","article-title":"Autocrine, endocrine and paracrine regulation of growth abnormalities in autosomal dominant polycystic kidney disease","volume":"61","author":"Wilson","year":"1993","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0545","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1111\/j.1523-1755.2004.00623.x","article-title":"EGF-related growth factors in the pathogenesis of murine ARPKD","volume":"65","author":"MacRae","year":"2004","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0550","first-page":"386","article-title":"Renal cysts in transgenic mice expressing transforming growth factor-alpha","volume":"124","author":"Lowden","year":"1994","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0555","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1172\/JCI2071","article-title":"Epidermal growth factor receptor activity mediates renal cyst formation in polycystic kidney disease","volume":"101","author":"Richards","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0560","doi-asserted-by":"crossref","first-page":"8335","DOI":"10.1074\/jbc.274.12.8335","article-title":"c-Src-mediated phosphorylation of the epidermal growth factor receptor on Tyr845 and Tyr1101 is associated with modulation of receptor function","volume":"274","author":"Biscardi","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0565","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/0092-8674(93)90634-3","article-title":"The when and how of Src regulation","volume":"73","author":"Cooper","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2010.10.004_bb0570","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/ki.1995.62","article-title":"Epidermal growth factor receptor expression is abnormal in murine polycystic kidney","volume":"47","author":"Orellana","year":"1995","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0575","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1007\/s00467-008-0851-9","article-title":"Pathways of apoptosis in human autosomal recessive and autosomal dominant polycystic kidney diseases","volume":"23","author":"Goilav","year":"2008","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0580","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1091\/mbc.e09-12-1059","article-title":"Autosomal recessive polycystic kidney disease epithelial cell model reveals multiple basolateral epidermal growth factor receptor sorting pathways","volume":"21","author":"Ryan","year":"2010","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbadis.2010.10.004_bb0585","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1091\/mbc.10.5.1621","article-title":"Endocytosis deficiency of epidermal growth factor (EGF) receptor-ErbB2 heterodimers in response to EGF stimulation","volume":"10","author":"Wang","year":"1999","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbadis.2010.10.004_bb0590","first-page":"3","article-title":"Identification of autophosphorylation sites of HER2\/neu","volume":"1","author":"Hazan","year":"1990","journal-title":"Cell Growth Differ."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0595","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1203\/00006450-199506000-00014","article-title":"Biliary epithelial cells from mice with congenital polycystic kidney disease are hyperresponsive to epidermal growth factor","volume":"37","author":"Nauta","year":"1995","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0600","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1083\/jcb.148.2.385","article-title":"ErbB2 is necessary for induction of carcinoma cell invasion by ErbB family receptor tyrosine kinases","volume":"148","author":"Spencer","year":"2000","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0605","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1128\/MCB.15.3.1182","article-title":"Single-chain antibody-mediated intracellular retention of ErbB-2 impairs Neu differentiation factor and epidermal growth factor signaling","volume":"15","author":"Graus-Porta","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0610","doi-asserted-by":"crossref","first-page":"6496","DOI":"10.1128\/MCB.15.12.6496","article-title":"Neu differentiation factor activation of ErbB-3 and ErbB-4 is cell specific and displays a differential requirement for ErbB-2","volume":"15","author":"Beerli","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0615","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.bbadis.2006.04.006","article-title":"Inhibition of HER-2(neu\/ErbB2) restores normal function and structure to polycystic kidney disease (PKD) epithelia","volume":"1762","author":"Wilson","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2010.10.004_bb0620","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/j.bbadis.2010.03.010","article-title":"Regulation of the epithelial sodium channel (ENaC) by membrane trafficking","volume":"1802","author":"M.B.","year":"2010","journal-title":"Biochimica Et Biophysica Acta (BBA) - Molecular Basis of Disease"},{"key":"10.1016\/j.bbadis.2010.10.004_bb0625","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1152\/physrev.1997.77.2.359","article-title":"Epithelial sodium channels: function, structure, and regulation","volume":"77","author":"Garty","year":"1997","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0630","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1146\/annurev.physiol.62.1.573","article-title":"Structure and regulation of amiloride-sensitive sodium channels","volume":"62","author":"Alvarez de la Rosa","year":"2000","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0635","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1152\/physrev.00007.2002","article-title":"Epithelial sodium channel\/degenerin family of ion channels: a variety of functions for a shared structure","volume":"82","author":"Kellenberger","year":"2002","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0640","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s10254-004-0023-7","article-title":"The epithelial sodium channel: from molecule to disease","volume":"151","author":"Schild","year":"2004","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0645","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1681\/ASN.2008020225","article-title":"Mechanisms of ENaC regulation and clinical implications","volume":"19","author":"Bhalla","year":"2008","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0650","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1146\/annurev.physiol.010908.163250","article-title":"The Contribution of Epithelial Sodium Channels to Alveolar Function in Health and Disease","volume":"71","author":"Eaton","year":"2009","journal-title":"An. Rev. Physiol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0655","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0092-8674(01)00241-0","article-title":"Molecular mechanisms of human hypertension","volume":"104","author":"Lifton","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2010.10.004_bb0660","doi-asserted-by":"crossref","unstructured":"E.D. Avner, W.E. Sweeney, Jr., Renal cystic disease: new insights for the clinician, Pediatr. Clin. North Am. 53 (2006) 889\u2013909, ix.","DOI":"10.1016\/j.pcl.2006.08.012"},{"key":"10.1016\/j.bbadis.2010.10.004_bb0665","first-page":"F434","article-title":"Epithelial cell polarity and disease","volume":"272","author":"Wilson","year":"1997","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0670","doi-asserted-by":"crossref","first-page":"F1034","DOI":"10.1152\/ajprenal.00195.2003","article-title":"Murine models of polycystic kidney disease: molecular and therapeutic insights","volume":"285","author":"Guay-Woodford","year":"2003","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0675","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1681\/ASN.V12147","article-title":"Epidermal growth factor activates store-operated calcium channels in human glomerular mesangial cells","volume":"12","author":"Ma","year":"2001","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0680","doi-asserted-by":"crossref","first-page":"4570","DOI":"10.1074\/jbc.M304334200","article-title":"Epidermal growth factor activates store-operated Ca2+ channels through an inositol 1, 4, 5-trisphosphate-independent pathway in human glomerular mesangial cells","volume":"279","author":"Li","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0685","doi-asserted-by":"crossref","first-page":"45","DOI":"10.2741\/3230","article-title":"The integrative function of TRPC channels","volume":"14","author":"Kiselyov","year":"2009","journal-title":"Front. Biosci."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0690","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1681\/ASN.2009090948","article-title":"Renal TRPathies","volume":"21","author":"Dietrich","year":"2010","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0695","doi-asserted-by":"crossref","first-page":"F1241","DOI":"10.1152\/ajprenal.00376.2005","article-title":"Identification and localization of TRPC channels in the rat kidney","volume":"290","author":"Goel","year":"2006","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0700","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/ncb1150","article-title":"Rapid vesicular translocation and insertion of TRP channels","volume":"6","author":"Bezzerides","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0705","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1134\/S1990747809030040","article-title":"Regulation of the epithelial sodium channels (ENaC) by small G proteins and phosphatidylinositides","volume":"3","author":"Karpushev","year":"2009","journal-title":"Biochemistry (Moscow) Supplemental Series A: Membrane and Cell Biology"},{"key":"10.1016\/j.bbadis.2010.10.004_bb0710","doi-asserted-by":"crossref","first-page":"26520","DOI":"10.1074\/jbc.M603716200","article-title":"Rapid translocation and insertion of the epithelial Na+channel in response to RhoA signaling","volume":"281","author":"Pochynyuk","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0715","doi-asserted-by":"crossref","first-page":"14576","DOI":"10.1074\/jbc.M701348200","article-title":"Quantifying RhoA facilitated trafficking of the epithelial Na+channel toward the plasma membrane with total internal reflection fluorescence-fluorescence recovery after photobleaching","volume":"282","author":"Pochynyuk","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0720","doi-asserted-by":"crossref","first-page":"49989","DOI":"10.1074\/jbc.M409812200","article-title":"Rho small GTPases activate the epithelial Na(+) channel","volume":"279","author":"Staruschenko","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0725","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/ng901","article-title":"Mutation of TRPM6 causes familial hypomagnesemia with secondary hypocalcemia","volume":"31","author":"Walder","year":"2002","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0730","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/ng889","article-title":"Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family","volume":"31","author":"Schlingmann","year":"2002","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0735","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1172\/JCI31680","article-title":"Impaired basolateral sorting of pro-EGF causes isolated recessive renal hypomagnesemia","volume":"117","author":"Groenestege","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0740","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.bbrc.2008.03.002","article-title":"TRPM6 expression and cell proliferation are up-regulated by phosphorylation of ERK1\/2 in renal epithelial cells","volume":"369","author":"Ikari","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0745","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/jcp.21988","article-title":"Up-regulation of TRPM6 transcriptional activity by AP-1 in renal epithelial cells","volume":"222","author":"Ikari","year":"2010","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0750","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1681\/ASN.2008030327","article-title":"EGF increases TRPM6 activity and surface expression","volume":"20","author":"Thebault","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0755","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1681\/ASN.2009111153","article-title":"W.J. van der, T.R. Alexander, I.M. Meijer, G.M. Mulder, G.H. van, S. Tejpar, J.G. Hoenderop, R.J. Bindels, Effects of the EGFR inhibitor erlotinib on magnesium handling","volume":"21","author":"Dimke","year":"2010","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0760","doi-asserted-by":"crossref","first-page":"8285","DOI":"10.1128\/MCB.25.18.8285-8298.2005","article-title":"PKD2 functions as an epidermal growth factor-activated plasma membrane channel","volume":"25","author":"Ma","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0765","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1126\/science.7618084","article-title":"Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype","volume":"269","author":"Threadgill","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2010.10.004_bb0770","doi-asserted-by":"crossref","first-page":"29728","DOI":"10.1074\/jbc.M400544200","article-title":"PKD2 interacts and co-localizes with mDia1 to mitotic spindles of dividing cells: role of mDia1 IN PKD2 localization to mitotic spindles","volume":"279","author":"Rundle","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0775","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1038\/emboj.2008.70","article-title":"Activation of TRPP2 through mDia1-dependent voltage gating","volume":"27","author":"Bai","year":"2008","journal-title":"EMBO J."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0780","doi-asserted-by":"crossref","first-page":"C82","DOI":"10.1152\/ajpcell.1998.275.1.C82","article-title":"Mechanisms of EGF-induced stimulation of sodium reabsorption by alveolar epithelial cells","volume":"275","author":"Danto","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0785","doi-asserted-by":"crossref","first-page":"9919","DOI":"10.1074\/jbc.271.17.9919","article-title":"Brush border phosphatidylinositol 3-kinase mediates epidermal growth factor stimulation of intestinal NaCl absorption and Na+\/H+exchange","volume":"271","author":"Khurana","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0790","first-page":"F163","article-title":"Site and mechanism of action of epidermal growth factor in rabbit cortical collecting duct","volume":"260","author":"Muto","year":"1991","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0795","first-page":"F803","article-title":"Effect of epidermal growth factor on sodium transport in the cortical collecting tubule","volume":"256","author":"Vehaskari","year":"1989","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0800","first-page":"F896","article-title":"Mechanism of sodium transport inhibition by epidermal growth factor in cortical collecting ducts","volume":"261","author":"Vehaskari","year":"1991","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0805","first-page":"F670","article-title":"EGF and PGE2 inhibit rabbit CCD Na+transport by different mechanisms: PGE2 inhibits Na(+)-K+pump","volume":"264","author":"Warden","year":"1993","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0810","doi-asserted-by":"crossref","first-page":"C1003","DOI":"10.1152\/ajpcell.00213.2004","article-title":"A role for ERK1\/2 in EGF- and ATP-dependent regulation of amiloride-sensitive sodium absorption","volume":"288","author":"Falin","year":"2005","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0815","doi-asserted-by":"crossref","first-page":"F57","DOI":"10.1152\/ajprenal.00028.2002","article-title":"Epidermal growth factor inhibits amiloride-sensitive sodium absorption in renal collecting duct cells","volume":"284","author":"Shen","year":"2003","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0820","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.bbrc.2005.03.201","article-title":"Chronic exposure to EGF affects trafficking and function of ENaC channel in cystic fibrosis cells","volume":"331","author":"Cao","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0825","doi-asserted-by":"crossref","first-page":"F150","DOI":"10.1152\/ajprenal.00261.2004","article-title":"Receptor tyrosine kinases mediate epithelial Na(+) channel inhibition by epidermal growth factor","volume":"288","author":"Tong","year":"2005","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0830","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1085\/jgp.200709775","article-title":"Acute downregulation of ENaC by EGF involves the PY motif and putative ERK phosphorylation site","volume":"130","author":"Falin","year":"2007","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0835","doi-asserted-by":"crossref","first-page":"F1226","DOI":"10.1152\/ajprenal.00378.2003","article-title":"Evidence for epidermal growth factor receptor as negative-feedback control in aldosterone-induced Na+reabsorption","volume":"286","author":"Grossmann","year":"2004","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0840","doi-asserted-by":"crossref","first-page":"F1201","DOI":"10.1152\/ajprenal.00383.2004","article-title":"Hydrogen peroxide and epidermal growth factor activate phosphatidylinositol 3-kinase and increase sodium transport in A6 cell monolayers","volume":"288","author":"Markadieu","year":"2005","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0845","doi-asserted-by":"crossref","first-page":"F1417","DOI":"10.1152\/ajprenal.90337.2008","article-title":"Biphasic regulation of ENaC by TGF-{alpha} and EGF in renal epithelial cells","volume":"296","author":"Liu","year":"2009","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0850","doi-asserted-by":"crossref","first-page":"L509","DOI":"10.1152\/ajplung.00230.2009","article-title":"Rac1-mediated NADPH oxidase release of OFormula regulates epithelial sodium channel activity in the alveolar epithelium","volume":"298","author":"Takemura","year":"2010","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0855","doi-asserted-by":"crossref","first-page":"51002","DOI":"10.1074\/jbc.M405674200","article-title":"ERK1\/2 controls Na, K-ATPase activity and transepithelial sodium transport in the principal cell of the cortical collecting duct of the mouse kidney","volume":"279","author":"Michlig","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0860","doi-asserted-by":"crossref","first-page":"F938","DOI":"10.1152\/ajprenal.00373.2002","article-title":"Targeted degradation of ENaC in response to PKC activation of the ERK1\/2 cascade","volume":"284","author":"Booth","year":"2003","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0865","doi-asserted-by":"crossref","first-page":"37771","DOI":"10.1074\/jbc.M402176200","article-title":"Ras activates the epithelial Na(+) channel through phosphoinositide 3-OH kinase signaling","volume":"279","author":"Staruschenko","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0870","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.bbamem.2005.01.005","article-title":"Ras couples phosphoinositide 3-OH kinase to the epithelial Na+channel","volume":"1669","author":"Staruschenko","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2010.10.004_bb0875","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1681\/ASN.2007010020","article-title":"Acute regulation of the epithelial Na+channel by phosphatidylinositide 3-OH kinase signaling in native collecting duct principal cells","volume":"18","author":"Staruschenko","year":"2007","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0880","doi-asserted-by":"crossref","first-page":"3417","DOI":"10.1091\/mbc.9.12.3417","article-title":"ras pathway activates epithelial Na+channel and decreases its surface expression in Xenopus oocytes","volume":"9","author":"Mastroberardino","year":"1998","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbadis.2010.10.004_bb0885","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s004240050403","article-title":"Characterization of early aldosterone-induced RNAs identified in A6 kidney epithelia","volume":"434","author":"Spindler","year":"1997","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0890","doi-asserted-by":"crossref","first-page":"C1154","DOI":"10.1152\/ajpcell.1999.276.5.C1154","article-title":"Aldosterone action: induction of p21ras and fra-2 and transcription-independent decrease in myc, jun, and fos","volume":"276","author":"Spindler","year":"1999","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0895","doi-asserted-by":"crossref","first-page":"35449","DOI":"10.1074\/jbc.274.50.35449","article-title":"Regulation of Na+reabsorption by the aldosterone-induced small G protein K-Ras2A","volume":"274","author":"Stockand","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0900","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.ceca.2007.10.001","article-title":"Growth factors differentially regulate neuronal Cav channels via ERK-dependent signalling","volume":"43","author":"Woodall","year":"2008","journal-title":"Cell Calcium"},{"key":"10.1016\/j.bbadis.2010.10.004_bb0905","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1681\/ASN.V134903","article-title":"Phosphatidylinositol 3-kinase activity is required for epidermal growth factor to suppress proteolysis","volume":"13","author":"Franch","year":"2002","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0910","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.1161\/01.CIR.0000131860.80444.AB","article-title":"aldosterone potentiates angiotensin II-induced signaling in vascular smooth muscle cells","volume":"109","author":"Mazak","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.bbadis.2010.10.004_bb0915","doi-asserted-by":"crossref","first-page":"F1323","DOI":"10.1152\/ajprenal.90428.2008","article-title":"Aldosterone-induced mesangial cell proliferation is mediated by EGF receptor transactivation","volume":"296","author":"Huang","year":"2009","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0920","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1038\/nm.1879","article-title":"Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease","volume":"14","author":"Shibata","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0925","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1161\/HYPERTENSIONAHA.109.149062","article-title":"Mineralocorticoid receptors, salt-sensitive hypertension, and metabolic syndrome","volume":"55","author":"Fujita","year":"2010","journal-title":"Hypertension"},{"key":"10.1016\/j.bbadis.2010.10.004_bb0930","doi-asserted-by":"crossref","first-page":"F421","DOI":"10.1152\/ajprenal.00472.2009","article-title":"Rac1 mediates NaCl-induced superoxide generation in the thick ascending limb","volume":"298","author":"Silva","year":"2009","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0935","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s00424-007-0294-3","article-title":"Regulation of the epithelial sodium channel by phosphatidylinositides: experiments, implications, and speculations","volume":"455","author":"Ma","year":"2007","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0940","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1016\/S0006-3495(00)76737-3","article-title":"Gating of amiloride-sensitive Na(+) channels: subunit-subunit interactions and inhibition by the cystic fibrosis transmembrane conductance regulator","volume":"78","author":"Berdiev","year":"2000","journal-title":"Biophys. J."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0945","doi-asserted-by":"crossref","first-page":"C511","DOI":"10.1152\/ajpcell.1995.269.2.C511","article-title":"Relative expression of the human epithelial Na+channel subunits in normal and cystic fibrosis airways","volume":"269","author":"Burch","year":"1995","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0950","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1126\/science.7543698","article-title":"CFTR as a cAMP-dependent regulator of sodium channels","volume":"269","author":"Stutts","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2010.10.004_bb0955","doi-asserted-by":"crossref","first-page":"14037","DOI":"10.1074\/jbc.272.22.14037","article-title":"Cystic fibrosis transmembrane conductance regulator inverts protein kinase A-mediated regulation of epithelial sodium channel single channel kinetics","volume":"272","author":"Stutts","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0960","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1039\/B810471A","article-title":"Assessment of the CFTR and ENaC association","volume":"5","author":"Berdiev","year":"2009","journal-title":"Mol. Biosyst."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0965","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/nm1028","article-title":"Increased airway epithelial Na+absorption produces cystic fibrosis-like lung disease in mice","volume":"10","author":"Mall","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0970","doi-asserted-by":"crossref","first-page":"27942","DOI":"10.1074\/jbc.M606449200","article-title":"Airway surface liquid volume regulates ENaC by altering the serine protease-protease inhibitor balance: a mechanism for sodium hyperabsorption in cystic fibrosis","volume":"281","author":"Myerburg","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0975","doi-asserted-by":"crossref","first-page":"C389","DOI":"10.1152\/ajpcell.1996.270.1.C389","article-title":"A role for CFTR in human autosomal dominant polycystic kidney disease","volume":"270","author":"Hanaoka","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0980","doi-asserted-by":"crossref","first-page":"3424","DOI":"10.1681\/ASN.2006030295","article-title":"Early embryonic renal tubules of wild-type and polycystic kidney disease kidneys respond to cAMP stimulation with cystic fibrosis transmembrane conductance regulator\/Na(+), K(+), 2Cl(-) Co-transporter-dependent cystic dilation","volume":"17","author":"Magenheimer","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0985","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1681\/ASN.2007070828","article-title":"Small-molecule CFTR inhibitors slow cyst growth in polycystic kidney disease","volume":"19","author":"Yang","year":"2008","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0990","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1681\/ASN.V124719","article-title":"Role of CFTR in autosomal recessive polycystic kidney disease","volume":"12","author":"Nakanishi","year":"2001","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb0995","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s00424-006-0123-0","article-title":"Regulation of NaCl transport in the renal collecting duct: lessons from cultured cells","volume":"453","author":"Bens","year":"2006","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.bbadis.2010.10.004_bb1000","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1097\/MNH.0b013e328332bda4","article-title":"Regulation of sodium transport by ENaC in the kidney","volume":"19","author":"Hamm","year":"2010","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"10.1016\/j.bbadis.2010.10.004_bb1005","doi-asserted-by":"crossref","first-page":"C947","DOI":"10.1152\/ajpcell.00640.2005","article-title":"Primary cilia and regulation of renal Na+transport. Focus on \"Heightened epithelial Na+channel-mediated Na+absorption in a murine polycystic kidney disease model epithelium lacking apical monocilia\"","volume":"290","author":"Gray","year":"2006","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb1010","doi-asserted-by":"crossref","first-page":"C952","DOI":"10.1152\/ajpcell.00339.2005","article-title":"Heightened epithelial Na+channel-mediated Na+absorption in a murine polycystic kidney disease model epithelium lacking apical monocilia","volume":"290","author":"Olteanu","year":"2006","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb1015","doi-asserted-by":"crossref","first-page":"F244","DOI":"10.1152\/ajprenal.00169.2003","article-title":"Decreased amiloride-sensitive Na+absorption in collecting duct principal cells isolated from BPK ARPKD mice","volume":"286","author":"Veizis","year":"2004","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb1020","doi-asserted-by":"crossref","first-page":"F474","DOI":"10.1152\/ajprenal.00227.2004","article-title":"Abnormal EGF-dependent regulation of sodium absorption in ARPKD collecting duct cells","volume":"288","author":"Veizis","year":"2005","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb1025","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1097\/01.ASN.0000056481.66379.B2","article-title":"Na transport in autosomal recessive polycystic kidney disease (ARPKD) cyst lining epithelial cells","volume":"14","author":"Rohatgi","year":"2003","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb1030","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1053\/snep.2001.20929","article-title":"The genetics and physiology of polycystic kidney disease","volume":"21","author":"Calvet","year":"2001","journal-title":"Semin. Nephrol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb1035","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1681\/ASN.V34984","article-title":"Cyst fluid from human autosomal dominant polycystic kidneys promotes cyst formation and expansion by renal epithelial cells in vitro","volume":"3","author":"Ye","year":"1992","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb1040","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1007\/s00467-004-1728-1","article-title":"Cyst fluid composition in human autosomal recessive polycystic kidney disease","volume":"20","author":"Rohatgi","year":"2005","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.bbadis.2010.10.004_bb1045","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1681\/ASN.2009121291","article-title":"Randomized clinical trial of long-acting somatostatin for autosomal dominant polycystic kidney and liver disease","volume":"21","author":"Hogan","year":"2010","journal-title":"J. Am. Soc. Nephrol."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443910002255?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443910002255?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T04:41:47Z","timestamp":1760416907000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443910002255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":209,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S0925443910002255"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2010.10.004","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epidermal growth factor-mediated proliferation and sodium transport in normal and PKD epithelial cells","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2010.10.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}