{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:34:01Z","timestamp":1791920041255,"version":"4.3.4"},"reference-count":151,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,11,20]],"date-time":"2014-11-20T00:00:00Z","timestamp":1416441600000},"content-version":"vor","delay-in-days":1207,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1016\/j.bbadis.2011.01.014","type":"journal-article","created":{"date-parts":[[2011,2,3]],"date-time":"2011-02-03T04:15:39Z","timestamp":1296706539000},"page":"956-963","source":"Crossref","is-referenced-by-count":210,"title":["Nuclear receptor PXR, transcriptional circuits and metabolic relevance"],"prefix":"10.1016","volume":"1812","author":[{"given":"Chibueze A.","family":"Ihunnah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxi","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bbadis.2011.01.014_bb0005","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0092-8674(00)80900-9","article-title":"An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway","volume":"92","author":"Kliewer","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2011.01.014_bb0010","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1146\/annurev.physiol.65.092101.142528","article-title":"Nuclear receptors and the control of metabolism","volume":"65","author":"Francis","year":"2003","journal-title":"Annu. Rev. Physiol."},{"issue":"1","key":"10.1016\/j.bbadis.2011.01.014_bb0015","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1210\/mend.14.1.0409","article-title":"The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution","volume":"14","author":"Jones","year":"2000","journal-title":"Mol. Endocrinol."},{"issue":"13","key":"10.1016\/j.bbadis.2011.01.014_bb0020","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.addr.2010.08.006","article-title":"Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR","volume":"62","author":"Tolson","year":"2010","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"22","key":"10.1016\/j.bbadis.2011.01.014_bb0025","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1016\/j.lfs.2004.09.042","article-title":"CAR and PXR expression and inducibility of CYP2B and CYP3A activities in rat and rabbit lungs","volume":"76","author":"Chirulli","year":"2005","journal-title":"Life Sci."},{"issue":"3","key":"10.1016\/j.bbadis.2011.01.014_bb0030","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1021\/mp060010s","article-title":"Role of nuclear receptors in the adaptive response to bile acids and cholestasis: pathogenetic and therapeutic considerations","volume":"3","author":"Zollner","year":"2006","journal-title":"Mol. Pharm."},{"issue":"3","key":"10.1016\/j.bbadis.2011.01.014_bb0035","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1517\/17425255.2.3.381","article-title":"Functional evolution of the pregnane X receptor","volume":"2","author":"Iyer","year":"2006","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"issue":"5","key":"10.1016\/j.bbadis.2011.01.014_bb0040","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1194\/jlr.M800647-JLR200","article-title":"Metabolomics reveals a novel vitamin E metabolite and attenuated vitamin E metabolism upon PXR activation","volume":"50","author":"Cho","year":"2009","journal-title":"J. Lipid Res."},{"issue":"43","key":"10.1016\/j.bbadis.2011.01.014_bb0045","doi-asserted-by":"crossref","first-page":"45139","DOI":"10.1074\/jbc.M405423200","article-title":"Ligand-activated pregnane X receptor interferes with HNF-4 signaling by targeting a common coactivator PGC-1alpha. Functional implications in hepatic cholesterol and glucose metabolism.","volume":"279","author":"Bhalla","year":"2004","journal-title":"J Biol Chem"},{"issue":"3","key":"10.1016\/j.bbadis.2011.01.014_bb0050","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.phrs.2004.03.005","article-title":"PXR and the regulation of apoA1 and HDL-cholesterol in rodents","volume":"50","author":"Bachmann","year":"2004","journal-title":"Pharmacol. Res."},{"issue":"3","key":"10.1016\/j.bbadis.2011.01.014_bb0055","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0041-3879(74)90050-6","article-title":"Hyperlipidaemia as a complication of rifampicin treatment","volume":"55","author":"Khogali","year":"1974","journal-title":"Tubercle"},{"issue":"6","key":"10.1016\/j.bbadis.2011.01.014_bb0060","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1073\/pnas.051014398","article-title":"An essential role for nuclear receptors SXR\/PXR in detoxification of cholestatic bile acids","volume":"98","author":"Xie","year":"2001","journal-title":"Proc. Natl Acad. Sci. USA"},{"issue":"3","key":"10.1016\/j.bbadis.2011.01.014_bb0065","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1124\/mol.104.007161","volume":"67","author":"Sugatani","year":"2005","journal-title":"Mol. Pharmacol."},{"issue":"6","key":"10.1016\/j.bbadis.2011.01.014_bb0070","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1073\/pnas.051551698","article-title":"The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity","volume":"98","author":"Staudinger","year":"2001","journal-title":"Proc. Natl Acad. Sci. USA"},{"issue":"3","key":"10.1016\/j.bbadis.2011.01.014_bb0075","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.bbamcr.2006.04.014","article-title":"Principles of hepatic organic anion transporter regulation during cholestasis, inflammation and liver regeneration","volume":"1773","author":"Geier","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"issue":"3","key":"10.1016\/j.bbadis.2011.01.014_bb0080","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.biocel.2006.08.017","article-title":"Pregnane X receptor: promiscuous regulator of detoxification pathways","volume":"39","author":"Matic","year":"2007","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.bbadis.2011.01.014_bb0085","first-page":"345","article-title":"The PPARs and PXRs: nuclear xenobiotic receptors that define novel hormone signaling pathways","volume":"54","author":"Kliewer","year":"1999","journal-title":"Recent Prog. Horm. Res."},{"issue":"5","key":"10.1016\/j.bbadis.2011.01.014_bb0090","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1172\/JCI3703","article-title":"The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions","volume":"102","author":"Lehmann","year":"1998","journal-title":"J. Clin. Invest."},{"issue":"21","key":"10.1016\/j.bbadis.2011.01.014_bb0095","doi-asserted-by":"crossref","first-page":"12208","DOI":"10.1073\/pnas.95.21.12208","article-title":"Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction","volume":"95","author":"Bertilsson","year":"1998","journal-title":"Proc. Natl Acad. Sci. USA"},{"issue":"20","key":"10.1016\/j.bbadis.2011.01.014_bb0100","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1101\/gad.12.20.3195","article-title":"SXR, a novel steroid and xenobiotic-sensing nuclear receptor","volume":"12","author":"Blumberg","year":"1998","journal-title":"Genes Dev."},{"issue":"5","key":"10.1016\/j.bbadis.2011.01.014_bb0105","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1210\/mend.16.5.0828","article-title":"Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors","volume":"16","author":"Moore","year":"2002","journal-title":"Mol. Endocrinol."},{"issue":"6794","key":"10.1016\/j.bbadis.2011.01.014_bb0110","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/35019116","article-title":"Humanized xenobiotic response in mice expressing nuclear receptor SXR","volume":"406","author":"Xie","year":"2000","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.bbadis.2011.01.014_bb0115","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1006\/abbi.1999.1307","article-title":"Rat pregnane X receptor: molecular cloning, tissue distribution, and xenobiotic regulation","volume":"368","author":"Zhang","year":"1999","journal-title":"Arch. Biochem. Biophys."},{"issue":"5","key":"10.1016\/j.bbadis.2011.01.014_bb0120","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0090-9556(24)15096-9","article-title":"Rabbit pregnane X receptor is activated by rifampicin","volume":"28","author":"Savas","year":"2000","journal-title":"Drug Metab. Dispos."},{"issue":"20","key":"10.1016\/j.bbadis.2011.01.014_bb0125","doi-asserted-by":"crossref","first-page":"10769","DOI":"10.1073\/pnas.97.20.10769","article-title":"CXR, a chicken xenobiotic-sensing orphan nuclear receptor, is related to both mammalian pregnane X receptor (PXR) and constitutive androstane receptor (CAR)","volume":"97","author":"Handschin","year":"2000","journal-title":"Proc. Natl Acad. Sci. USA"},{"issue":"5548","key":"10.1016\/j.bbadis.2011.01.014_bb0130","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1126\/science.294.5548.1866","article-title":"Nuclear receptors and lipid physiology: opening the X-files","volume":"294","author":"Chawla","year":"2001","journal-title":"Science"},{"issue":"43","key":"10.1016\/j.bbadis.2011.01.014_bb0135","doi-asserted-by":"crossref","first-page":"40065","DOI":"10.1074\/jbc.M105260200","article-title":"Signaling complexes of the FERM domain-containing protein GRSP1 bound to ARF exchange factor GRP1","volume":"276","author":"Klarlund","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.bbadis.2011.01.014_bb0140","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1210\/me.2005-0156","article-title":"The nuclear xenobiotic receptor pregnane X receptor: recent insights and new challenges","volume":"19","author":"Orans","year":"2005","journal-title":"Mol. Endocrinol."},{"issue":"Pt 4","key":"10.1016\/j.bbadis.2011.01.014_bb0145","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1242\/jcs.00247","article-title":"The nuclear receptor superfamily","volume":"116","author":"Robinson-Rechavi","year":"2003","journal-title":"J. Cell Sci."},{"issue":"11","key":"10.1016\/j.bbadis.2011.01.014_bb0150","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.2217\/14622416.9.11.1695","article-title":"PXR: a xenobiotic receptor of diverse function implicated in pharmacogenetics","volume":"9","author":"Zhang","year":"2008","journal-title":"Pharmacogenomics"},{"issue":"47","key":"10.1016\/j.bbadis.2011.01.014_bb0155","doi-asserted-by":"crossref","first-page":"49307","DOI":"10.1074\/jbc.M407281200","article-title":"Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver","volume":"279","author":"Squires","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.bbadis.2011.01.014_bb0160","doi-asserted-by":"crossref","first-page":"G74","DOI":"10.1152\/ajpgi.00258.2004","article-title":"Mechanism of rifampicin and pregnane X receptor inhibition of human cholesterol 7 alpha-hydroxylase gene transcription","volume":"288","author":"Li","year":"2005","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"6","key":"10.1016\/j.bbadis.2011.01.014_bb0165","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/0092-8674(95)90200-7","article-title":"The RXR heterodimers and orphan receptors","volume":"83","author":"Mangelsdorf","year":"1995","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.bbadis.2011.01.014_bb0170","first-page":"321","article-title":"Nuclear receptor coregulators: cellular and molecular biology","volume":"20","author":"McKenna","year":"1999","journal-title":"Endocr. Rev."},{"issue":"7","key":"10.1016\/j.bbadis.2011.01.014_bb0175","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/0092-8674(89)90051-2","article-title":"Determinants of target gene specificity for steroid\/thyroid hormone receptors","volume":"57","author":"Umesono","year":"1989","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.bbadis.2011.01.014_bb0180","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1007\/s00335-007-9007-7","article-title":"Comparative genomics of xenobiotic metabolism: a porcine-human PXR gene comparison","volume":"18","author":"Pollock","year":"2007","journal-title":"Mamm. Genome"},{"issue":"1\u20132","key":"10.1016\/j.bbadis.2011.01.014_bb0185","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.mce.2004.12.005","article-title":"Steroid and xenobiotic receptor (SXR), cytochrome P450 3A4 and multidrug resistance gene 1 in human adult and fetal tissues","volume":"231","author":"Miki","year":"2005","journal-title":"Mol. Cell. Endocrinol."},{"issue":"3","key":"10.1016\/j.bbadis.2011.01.014_bb0190","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.taap.2003.12.027","article-title":"PXR (NR1I2): splice variants in human tissues, including brain, and identification of neurosteroids and nicotine as PXR activators","volume":"199","author":"Lamba","year":"2004","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"3","key":"10.1016\/j.bbadis.2011.01.014_bb0195","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0026-895X(24)05623-2","article-title":"Pregnane X receptor up-regulation of P-glycoprotein expression and transport function at the blood-brain barrier","volume":"66","author":"Bauer","year":"2004","journal-title":"Mol. Pharmacol."},{"issue":"4","key":"10.1016\/j.bbadis.2011.01.014_bb0200","doi-asserted-by":"crossref","first-page":"369","DOI":"10.2174\/1389200054633880","article-title":"Genetic variants of PXR (NR1I2) and CAR (NR1I3) and their implications in drug metabolism and pharmacogenetics","volume":"6","author":"Lamba","year":"2005","journal-title":"Curr. Drug Metab."},{"issue":"1","key":"10.1016\/j.bbadis.2011.01.014_bb0205","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1124\/dmd.104.002071","article-title":"Structural and functional diversity in heme monooxygenases","volume":"33","author":"Poulos","year":"2005","journal-title":"Drug Metab. Dispos."},{"issue":"2","key":"10.1016\/j.bbadis.2011.01.014_bb0210","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1023\/A:1015920931701","article-title":"Cytochrome P450: molecular architecture, mechanism, and prospects for rational inhibitor design","volume":"5","author":"Poulos","year":"1988","journal-title":"Pharm. Res."},{"issue":"4","key":"10.1016\/j.bbadis.2011.01.014_bb0215","doi-asserted-by":"crossref","first-page":"447","DOI":"10.2131\/jts.33.447","article-title":"Strain differences in hepatic cytochrome P450 1A and 3A expression between Sprague\u2013Dawley and Wistar rats","volume":"33","author":"Kishida","year":"2008","journal-title":"J. Toxicol. Sci."},{"issue":"10","key":"10.1016\/j.bbadis.2011.01.014_bb0220","first-page":"1325","article-title":"Calcium channel modulators of the dihydropyridine family are human pregnane X receptor activators and inducers of CYP3A, CYP2B, and CYP2C in human hepatocytes","volume":"29","author":"Drocourt","year":"2001","journal-title":"Drug Metab. Dispos."},{"issue":"3","key":"10.1016\/j.bbadis.2011.01.014_bb0225","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1124\/mol.105.013169","article-title":"Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4alpha","volume":"68","author":"Ferguson","year":"2005","journal-title":"Mol. Pharmacol."},{"issue":"1","key":"10.1016\/j.bbadis.2011.01.014_bb0230","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.toxlet.2009.12.014","article-title":"Species-specific activation of nuclear receptors correlates with the response of liver drug metabolizing enzymes to EMD 392949 in vitro","volume":"193","author":"Mueller","year":"2010","journal-title":"Toxicol. Lett."},{"issue":"21","key":"10.1016\/j.bbadis.2011.01.014_bb0235","doi-asserted-by":"crossref","first-page":"13801","DOI":"10.1073\/pnas.212494599","article-title":"Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR)","volume":"99","author":"Sonoda","year":"2002","journal-title":"Proc. Natl Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.bbadis.2011.01.014_bb0240","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1124\/jpet.107.121913","article-title":"Rifaximin is a gut-specific human pregnane X receptor activator","volume":"322","author":"Ma","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"6","key":"10.1016\/j.bbadis.2011.01.014_bb0245","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1124\/mol.56.6.1329","article-title":"The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module","volume":"56","author":"Goodwin","year":"1999","journal-title":"Mol. Pharmacol."},{"issue":"10","key":"10.1016\/j.bbadis.2011.01.014_bb0250","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/S0006-2952(02)01298-4","article-title":"PXR-dependent induction of human CYP3A4 gene expression by organochlorine pesticides","volume":"64","author":"Coumoul","year":"2002","journal-title":"Biochem. Pharmacol."},{"issue":"2","key":"10.1016\/j.bbadis.2011.01.014_bb0255","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1124\/mol.64.2.474","article-title":"The environmental pollutant 1, 1-dichloro-2, 2-bis (p-chlorophenyl)ethylene induces rat hepatic cytochrome P450 2B and 3A expression through the constitutive androstane receptor and pregnane X receptor","volume":"64","author":"Wyde","year":"2003","journal-title":"Mol. Pharmacol."},{"issue":"2","key":"10.1016\/j.bbadis.2011.01.014_bb0260","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1093\/toxsci\/kfi204","article-title":"Di-n-butyl phthalate activates constitutive androstane receptor and pregnane X receptor and enhances the expression of steroid-metabolizing enzymes in the liver of rat fetuses","volume":"86","author":"Wyde","year":"2005","journal-title":"Toxicol. Sci."},{"issue":"3","key":"10.1016\/j.bbadis.2011.01.014_bb0265","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1208\/s12248-009-9135-y","article-title":"Activation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) by herbal medicines","volume":"11","author":"Chang","year":"2009","journal-title":"AAPS J."},{"issue":"3","key":"10.1016\/j.bbadis.2011.01.014_bb0270","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/BF02977789","article-title":"Induction of phase I, II and III drug metabolism\/transport by xenobiotics.","volume":"28","author":"Xu","year":"2005","journal-title":"Arch. Pharm. Res."},{"issue":"15","key":"10.1016\/j.bbadis.2011.01.014_bb0275","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.2165\/00003088-200342150-00003","article-title":"Role of orphan nuclear receptors in the regulation of drug-metabolising enzymes","volume":"42","author":"Wang","year":"2003","journal-title":"Clin. Pharmacokinet."},{"issue":"7","key":"10.1016\/j.bbadis.2011.01.014_bb0280","doi-asserted-by":"crossref","first-page":"4150","DOI":"10.1073\/pnas.0438010100","article-title":"Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor","volume":"100","author":"Xie","year":"2003","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.bbadis.2011.01.014_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2010.04.034","article-title":"Functions and transcriptional regulation of adult human hepatic UDP-glucuronosyl-transferases (UGTs): mechanisms responsible for interindividual variation of UGT levels","author":"Bock","year":"2010","journal-title":"Biochem. Pharmacol."},{"issue":"4","key":"10.1016\/j.bbadis.2011.01.014_bb0290","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1124\/dmd.108.024190","volume":"37","author":"Buckley","year":"2009","journal-title":"Drug Metab. Dispos."},{"issue":"3","key":"10.1016\/j.bbadis.2011.01.014_bb0295","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1021\/mp060020t","article-title":"Coordinate regulation of hepatic bile acid oxidation and conjugation by nuclear receptors","volume":"3","author":"Trottier","year":"2006","journal-title":"Mol. Pharm."},{"issue":"3","key":"10.1016\/j.bbadis.2011.01.014_bb0300","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1124\/dmd.32.3.340","article-title":"Human PXR variants and their differential effects on the regulation of human UDP-glucuronosyltransferase gene expression","volume":"32","author":"Gardner-Stephen","year":"2004","journal-title":"Drug Metab. Dispos."},{"issue":"6","key":"10.1016\/j.bbadis.2011.01.014_bb0305","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.metabol.2006.01.006","article-title":"N-Glucuronidation of the antiepileptic drug retigabine: results from studies with human volunteers, heterologously expressed human UGTs, human liver, kidney, and liver microsomal membranes of Crigler-Najjar type II","volume":"55","author":"Borlak","year":"2006","journal-title":"Metabolism"},{"issue":"5","key":"10.1016\/j.bbadis.2011.01.014_bb0310","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/hup.403","article-title":"Glucuronidation of olanzapine by cDNA-expressed human UDP-glucuronosyltransferases and human liver microsomes","volume":"17","author":"Linnet","year":"2002","journal-title":"Hum. Psychopharmacol."},{"issue":"25\u201326","key":"10.1016\/j.bbadis.2011.01.014_bb0315","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1016\/j.lfs.2007.09.029","article-title":"Induction of human sulfotransferase 1A3 (SULT1A3) by glucocorticoids","volume":"81","author":"Bian","year":"2007","journal-title":"Life Sci."},{"issue":"2","key":"10.1016\/j.bbadis.2011.01.014_bb0320","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1124\/jpet.107.129650","article-title":"Regulation of sulfotransferase enzymes by prototypical microsomal enzyme inducers in mice","volume":"324","author":"Alnouti","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"9","key":"10.1016\/j.bbadis.2011.01.014_bb0325","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1124\/dmd.30.9.997","article-title":"Effects of dexamethasone on aryl (SULT1A1)- and hydroxysteroid (SULT2A1)-sulfotransferase gene expression in primary cultured human hepatocytes","volume":"30","author":"Duanmu","year":"2002","journal-title":"Drug Metab. Dispos."},{"issue":"2","key":"10.1016\/j.bbadis.2011.01.014_bb0330","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1124\/jpet.107.124610","article-title":"Positive and negative regulation of human hepatic hydroxysteroid sulfotransferase (SULT2A1) gene transcription by rifampicin: roles of hepatocyte nuclear factor 4alpha and pregnane X receptor","volume":"323","author":"Fang","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"4","key":"10.1016\/j.bbadis.2011.01.014_bb0335","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1124\/mol.104.005389","article-title":"Regulation of human hepatic hydroxysteroid sulfotransferase gene expression by the peroxisome proliferator-activated receptor alpha transcription factor","volume":"67","author":"Fang","year":"2005","journal-title":"Mol. Pharmacol."},{"issue":"1","key":"10.1016\/j.bbadis.2011.01.014_bb0340","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1093\/toxsci\/kfq115","article-title":"Genetic and epigenetic regulation and expression signatures of glutathione S-transferases in developing mouse liver","volume":"116","author":"Cui","year":"2010","journal-title":"Toxicol. Sci."},{"issue":"2","key":"10.1016\/j.bbadis.2011.01.014_bb0345","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1093\/toxsci\/kfn179","article-title":"Induction of hepatic glutathione S-transferases in male mice by prototypes of various classes of microsomal enzyme inducers","volume":"106","author":"Knight","year":"2008","journal-title":"Toxicol. Sci."},{"issue":"1","key":"10.1016\/j.bbadis.2011.01.014_bb0350","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/toxsci\/kfn058","article-title":"Pregnane X receptor protects HepG2 cells from BaP-induced DNA damage","volume":"104","author":"Naspinski","year":"2008","journal-title":"Toxicol. Sci."},{"issue":"1","key":"10.1016\/j.bbadis.2011.01.014_bb0355","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1124\/jpet.103.061713","article-title":"Induction of drug metabolism enzymes and MDR1 using a novel human hepatocyte cell line","volume":"309","author":"Mills","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"1\u20133","key":"10.1016\/j.bbadis.2011.01.014_bb0360","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0378-4274(01)00306-X","article-title":"Up-regulation of transporters of the MRP family by drugs and toxins","volume":"120","author":"Schrenk","year":"2001","journal-title":"Toxicol. Lett."},{"issue":"10","key":"10.1016\/j.bbadis.2011.01.014_bb0365","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1124\/dmd.106.010033","article-title":"Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes","volume":"34","author":"Jigorel","year":"2006","journal-title":"Drug Metab. Dispos."},{"issue":"21","key":"10.1016\/j.bbadis.2011.01.014_bb0370","doi-asserted-by":"crossref","first-page":"22250","DOI":"10.1074\/jbc.M314111200","article-title":"Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice","volume":"279","author":"Assem","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.bbadis.2011.01.014_bb0375","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s00424-003-1168-y","article-title":"Organic anion transporting polypeptides of the OATP\/SLC21 family: phylogenetic classification as OATP\/SLCO superfamily, new nomenclature and molecular\/functional properties","volume":"447","author":"Hagenbuch","year":"2004","journal-title":"Pflugers Arch."},{"issue":"3","key":"10.1016\/j.bbadis.2011.01.014_bb0380","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0022-3565(24)29202-8","article-title":"Rifampin is a selective, pleiotropic inducer of drug metabolism genes in human hepatocytes: studies with cDNA and oligonucleotide expression arrays","volume":"299","author":"Rae","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"5","key":"10.1016\/j.bbadis.2011.01.014_bb0385","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1210\/er.2001-0038","article-title":"The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism","volume":"23","author":"Kliewer","year":"2002","journal-title":"Endocr. Rev."},{"issue":"6","key":"10.1016\/j.bbadis.2011.01.014_bb0390","doi-asserted-by":"crossref","first-page":"493","DOI":"10.2165\/00003088-200038060-00003","article-title":"Induction of drug metabolising enzymes: pharmacokinetic and toxicological consequences in humans","volume":"38","author":"Fuhr","year":"2000","journal-title":"Clin. Pharmacokinet."},{"issue":"13","key":"10.1016\/j.bbadis.2011.01.014_bb0395","doi-asserted-by":"crossref","first-page":"7500","DOI":"10.1073\/pnas.130155097","article-title":"St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor.","volume":"97","author":"Moore","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.bbadis.2011.01.014_bb0400","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.clpt.2004.07.004","article-title":"Hyperforin content determines the magnitude of the St John's wort\u2013cyclosporine drug interaction","volume":"76","author":"Mai","year":"2004","journal-title":"Clin. Pharmacol. Ther."},{"issue":"9","key":"10.1016\/j.bbadis.2011.01.014_bb0405","doi-asserted-by":"crossref","first-page":"819","DOI":"10.2165\/00003088-200342090-00003","article-title":"Pharmacokinetic interactions with rifampicin: clinical relevance","volume":"42","author":"Niemi","year":"2003","journal-title":"Clin. Pharmacokinet."},{"issue":"5","key":"10.1016\/j.bbadis.2011.01.014_bb0410","first-page":"255","article-title":"The simultaneous use of rifampicin and other antitubercular agents with oral contraceptives","volume":"25","author":"Reimers","year":"1971","journal-title":"Prax Pneumol."},{"issue":"1","key":"10.1016\/j.bbadis.2011.01.014_bb0415","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0009-9236(96)90018-1","article-title":"Rifampin drastically reduces plasma concentrations and effects of oral midazolam","volume":"59","author":"Backman","year":"1996","journal-title":"Clin. Pharmacol. Ther."},{"issue":"2","key":"10.1016\/j.bbadis.2011.01.014_bb0420","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1128\/AAC.45.2.502-508.2001","article-title":"Pharmacokinetic interaction between amprenavir and rifabutin or rifampin in healthy males","volume":"45","author":"Polk","year":"2001","journal-title":"Antimicrob. Agents Chemother."},{"issue":"2","key":"10.1016\/j.bbadis.2011.01.014_bb0425","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s002280100277","article-title":"The interaction of saquinavir (soft gelatin capsule) with ketoconazole, erythromycin and rifampicin: comparison of the effect in healthy volunteers and in HIV-infected patients","volume":"57","author":"Grub","year":"2001","journal-title":"Eur. J. Clin. Pharmacol."},{"issue":"1\u20133","key":"10.1016\/j.bbadis.2011.01.014_bb0430","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0300-483X(00)00300-0","article-title":"Use of the nuclear receptor PXR to predict drug interactions","volume":"153","author":"Moore","year":"2000","journal-title":"Toxicology"},{"issue":"8","key":"10.1016\/j.bbadis.2011.01.014_bb0435","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1177\/153537020222700807","article-title":"The biochemistry and molecular biology of the glucose-6-phosphatase system","volume":"227","author":"Foster","year":"2002","journal-title":"Exp. Biol. Med. (Maywood)"},{"issue":"4","key":"10.1016\/j.bbadis.2011.01.014_bb0440","doi-asserted-by":"crossref","first-page":"423","DOI":"10.2174\/156800805774912962","article-title":"Insulin regulation of PEPCK gene expression: a model for rapid and reversible modulation","volume":"5","author":"Quinn","year":"2005","journal-title":"Curr Drug Targets Immune Endocr Metabol Disord"},{"issue":"6852","key":"10.1016\/j.bbadis.2011.01.014_bb0445","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/35093131","article-title":"CREB regulates hepatic gluconeogenesis through the coactivator PGC-1","volume":"413","author":"Herzig","year":"2001","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.bbadis.2011.01.014_bb0450","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2174\/0929867033368556","article-title":"Potential drug targets and progress towards pharmacologic inhibition of hepatic glucose production","volume":"10","author":"Kurukulasuriya","year":"2003","journal-title":"Curr. Med. Chem."},{"issue":"9","key":"10.1016\/j.bbadis.2011.01.014_bb0455","doi-asserted-by":"crossref","first-page":"4712","DOI":"10.1128\/MCB.10.9.4712","article-title":"Characterization of a complex glucocorticoid response unit in the phosphoenolpyruvate carboxykinase gene","volume":"10","author":"Imai","year":"1990","journal-title":"Mol. Cell. Biol."},{"issue":"9","key":"10.1016\/j.bbadis.2011.01.014_bb0460","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1172\/JCI200112876","article-title":"The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression","volume":"108","author":"Nakae","year":"2001","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.bbadis.2011.01.014_bb0465","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1042\/BJ20070481","article-title":"Human nuclear pregnane X receptor cross-talk with CREB to repress cAMP activation of the glucose-6-phosphatase gene","volume":"407","author":"Kodama","year":"2007","journal-title":"Biochem. J."},{"issue":"20","key":"10.1016\/j.bbadis.2011.01.014_bb0470","doi-asserted-by":"crossref","first-page":"11285","DOI":"10.1073\/pnas.1934283100","article-title":"Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation","volume":"100","author":"Matsuzaki","year":"2003","journal-title":"Proc. Natl Acad. Sci. USA"},{"issue":"21","key":"10.1016\/j.bbadis.2011.01.014_bb0475","doi-asserted-by":"crossref","first-page":"15013","DOI":"10.1074\/jbc.M511116200","article-title":"A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway","volume":"281","author":"Zhou","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"18","key":"10.1016\/j.bbadis.2011.01.014_bb0480","doi-asserted-by":"crossref","first-page":"7931","DOI":"10.1128\/MCB.24.18.7931-7940.2004","article-title":"Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes","volume":"24","author":"Kodama","year":"2004","journal-title":"Mol. Cell. Biol."},{"issue":"1","key":"10.1016\/j.bbadis.2011.01.014_bb0485","doi-asserted-by":"crossref","first-page":"8","DOI":"10.2133\/dmpk.23.8","article-title":"The roles of nuclear receptors CAR and PXR in hepatic energy metabolism","volume":"23","author":"Konno","year":"2008","journal-title":"Drug Metab. Pharmacokinet."},{"issue":"9","key":"10.1016\/j.bbadis.2011.01.014_bb0490","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.1128\/MCB.21.9.2991-3000.2001","article-title":"Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter","volume":"21","author":"Yoshikawa","year":"2001","journal-title":"Mol. Cell. Biol."},{"issue":"38","key":"10.1016\/j.bbadis.2011.01.014_bb0495","doi-asserted-by":"crossref","first-page":"36176","DOI":"10.1074\/jbc.M302387200","article-title":"Sterol regulatory element-binding protein-2 interacts with hepatocyte nuclear factor-4 to enhance sterol isomerase gene expression in hepatocytes","volume":"278","author":"Misawa","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"14","key":"10.1016\/j.bbadis.2011.01.014_bb0500","doi-asserted-by":"crossref","first-page":"10290","DOI":"10.1074\/jbc.M700270200","article-title":"Interaction between sterol regulatory element-binding proteins and liver receptor homolog-1 reciprocally suppresses their transcriptional activities","volume":"282","author":"Kanayama","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.bbadis.2011.01.014_bb0505","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1016\/j.biocel.2007.03.012","article-title":"CD36: implications in cardiovascular disease","volume":"39","author":"Febbraio","year":"2007","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"12","key":"10.1016\/j.bbadis.2011.01.014_bb0510","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.2337\/db07-0907","article-title":"Increased hepatic CD36 expression contributes to dyslipidemia associated with diet-induced obesity","volume":"56","author":"Koonen","year":"2007","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.bbadis.2011.01.014_bb0515","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1053\/j.gastro.2007.11.037","article-title":"Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis","volume":"134","author":"Zhou","year":"2008","journal-title":"Gastroenterology"},{"issue":"Pt 3","key":"10.1016\/j.bbadis.2011.01.014_bb0520","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1042\/0264-6021:3380569","article-title":"Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase: a control enzyme in ketogenesis","volume":"338","author":"Hegardt","year":"1999","journal-title":"Biochem. J."},{"issue":"Pt 2","key":"10.1016\/j.bbadis.2011.01.014_bb0525","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1042\/bst0290310","article-title":"Regulation of liver carnitine palmitoyltransferase I gene expression by hormones and fatty acids","volume":"29","author":"Louet","year":"2001","journal-title":"Biochem. Soc. Trans."},{"issue":"7020","key":"10.1016\/j.bbadis.2011.01.014_bb0530","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/nature03047","article-title":"Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes","volume":"432","author":"Wolfrum","year":"2004","journal-title":"Nature"},{"issue":"20","key":"10.1016\/j.bbadis.2011.01.014_bb0535","doi-asserted-by":"crossref","first-page":"11624","DOI":"10.1073\/pnas.1931483100","article-title":"Insulin regulates the activity of forkhead transcription factor Hnf-3beta\/Foxa-2 by Akt-mediated phosphorylation and nuclear\/cytosolic localization","volume":"100","author":"Wolfrum","year":"2003","journal-title":"Proc. Natl Acad. Sci. USA"},{"issue":"13","key":"10.1016\/j.bbadis.2011.01.014_bb0540","doi-asserted-by":"crossref","first-page":"9768","DOI":"10.1074\/jbc.M610072200","article-title":"Nuclear pregnane X receptor cross-talk with FoxA2 to mediate drug-induced regulation of lipid metabolism in fasting mouse liver","volume":"282","author":"Nakamura","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.bbadis.2011.01.014_bb0545","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/S0955-2863(02)00222-X","article-title":"Oxidized products of cholesterol: dietary and metabolic origin, and proatherosclerotic effects (review)","volume":"13","author":"Leonarduzzi","year":"2002","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.bbadis.2011.01.014_bb0550","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1146\/annurev.biochem.72.121801.161712","article-title":"The enzymes, regulation, and genetics of bile acid synthesis","volume":"72","author":"Russell","year":"2003","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.bbadis.2011.01.014_bb0555","doi-asserted-by":"crossref","first-page":"d176","DOI":"10.2741\/A273","article-title":"Regulation of bile acid synthesis","volume":"3","author":"Chiang","year":"1998","journal-title":"Front. Biosci."},{"issue":"2","key":"10.1016\/j.bbadis.2011.01.014_bb0560","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1194\/jlr.M600282-JLR200","article-title":"PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine","volume":"48","author":"Li","year":"2007","journal-title":"J. Lipid Res."},{"issue":"10","key":"10.1016\/j.bbadis.2011.01.014_bb0565","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1161\/01.ATV.0000183674.88817.fb","article-title":"Expression of the pregnane X receptor in mice antagonizes the cholic acid-mediated changes in plasma lipoprotein profile","volume":"25","author":"Masson","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"4","key":"10.1016\/j.bbadis.2011.01.014_bb0570","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1016\/j.bbrc.2005.04.071","article-title":"Pregnane X receptor-agonists down-regulate hepatic ATP-binding cassette transporter A1 and scavenger receptor class B type I","volume":"331","author":"Sporstol","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"7","key":"10.1016\/j.bbadis.2011.01.014_bb0575","doi-asserted-by":"crossref","first-page":"F51","DOI":"10.1097\/00002030-199807000-00003","article-title":"A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors","volume":"12","author":"Carr","year":"1998","journal-title":"AIDS"},{"issue":"6","key":"10.1016\/j.bbadis.2011.01.014_bb0580","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1212\/WNL.45.6.1155","article-title":"Effects of long-term treatment with antiepileptic drugs on serum lipid levels in children with epilepsy","volume":"45","author":"Eiris","year":"1995","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.bbadis.2011.01.014_bb0585","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1210\/me.2006-0291","article-title":"Activation of pregnane X receptor disrupts glucocorticoid and mineralocorticoid homeostasis","volume":"21","author":"Zhai","year":"2007","journal-title":"Mol. Endocrinol."},{"issue":"4","key":"10.1016\/j.bbadis.2011.01.014_bb0590","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1007\/BF02943098","article-title":"The effects of therapy with rifampicin and isoniazid on basic investigations for Cushing's syndrome","volume":"165","author":"Zawawi","year":"1996","journal-title":"Ir. J. Med. Sci."},{"issue":"3","key":"10.1016\/j.bbadis.2011.01.014_bb0595","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1055\/s-2007-979927","article-title":"Misdiagnosis of Cushing's syndrome in a patient receiving rifampicin therapy for tuberculosis","volume":"27","author":"Terzolo","year":"1995","journal-title":"Horm. Metab. Res."},{"issue":"6","key":"10.1016\/j.bbadis.2011.01.014_bb0600","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1080\/004982598239290","article-title":"Contribution of human hepatic cytochrome P450 isoforms to regioselective hydroxylation of steroid hormones","volume":"28","author":"Niwa","year":"1998","journal-title":"Xenobiotica"},{"issue":"5","key":"10.1016\/j.bbadis.2011.01.014_bb0605","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1210\/er.2001-0040","article-title":"Sulfonation and molecular action","volume":"23","author":"Strott","year":"2002","journal-title":"Endocr. Rev."},{"issue":"12","key":"10.1016\/j.bbadis.2011.01.014_bb0610","doi-asserted-by":"crossref","first-page":"5721","DOI":"10.1210\/en.2010-0708","article-title":"Pregnane X receptor as a therapeutic target to inhibit androgen activity","volume":"151","author":"Zhang","year":"2010","journal-title":"Endocrinology"},{"issue":"7","key":"10.1016\/j.bbadis.2011.01.014_bb0615","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.molmed.2007.06.001","article-title":"Targeting farnesoid X receptor for liver and metabolic disorders","volume":"13","author":"Fiorucci","year":"2007","journal-title":"Trends Mol. Med."},{"issue":"22","key":"10.1016\/j.bbadis.2011.01.014_bb0620","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1001\/archinte.159.22.2647","article-title":"The continuing importance of bile acids in liver and intestinal disease","volume":"159","author":"Hofmann","year":"1999","journal-title":"Arch. Intern. Med."},{"issue":"4","key":"10.1016\/j.bbadis.2011.01.014_bb0625","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.1074\/jbc.M109326200","article-title":"Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor","volume":"277","author":"Kast","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.bbadis.2011.01.014_bb0630","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.jmb.2004.12.003","article-title":"Identification of pregnane X receptor binding sites in the regulatory regions of genes involved in bile acid homeostasis","volume":"346","author":"Frank","year":"2005","journal-title":"J. Mol. Biol."},{"issue":"28","key":"10.1016\/j.bbadis.2011.01.014_bb0635","doi-asserted-by":"crossref","first-page":"19081","DOI":"10.1074\/jbc.M600116200","article-title":"Pregnane X receptor is a target of farnesoid X receptor","volume":"281","author":"Jung","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"45","key":"10.1016\/j.bbadis.2011.01.014_bb0640","doi-asserted-by":"crossref","first-page":"43919","DOI":"10.1074\/jbc.M303136200","article-title":"Vitamin K2 regulation of bone homeostasis is mediated by the steroid and xenobiotic receptor SXR","volume":"278","author":"Tabb","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"25","key":"10.1016\/j.bbadis.2011.01.014_bb0645","doi-asserted-by":"crossref","first-page":"16927","DOI":"10.1074\/jbc.M600896200","article-title":"Steroid and xenobiotic receptor SXR mediates vitamin K2-activated transcription of extracellular matrix-related genes and collagen accumulation in osteoblastic cells","volume":"281","author":"Ichikawa","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"22","key":"10.1016\/j.bbadis.2011.01.014_bb0650","doi-asserted-by":"crossref","first-page":"7947","DOI":"10.1128\/MCB.00813-07","article-title":"Vitamin K induces osteoblast differentiation through pregnane X receptor-mediated transcriptional control of the Msx2 gene","volume":"27","author":"Igarashi","year":"2007","journal-title":"Mol. Cell. Biol."},{"issue":"4","key":"10.1016\/j.bbadis.2011.01.014_bb0655","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1152\/physrev.1998.78.4.1193","article-title":"Current understanding of the molecular actions of vitamin D","volume":"78","author":"Jones","year":"1998","journal-title":"Physiol. Rev."},{"issue":"1","key":"10.1016\/j.bbadis.2011.01.014_bb0660","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1172\/JCI21867","article-title":"Possible involvement of pregnane X receptor-enhanced CYP24 expression in drug-induced osteomalacia","volume":"115","author":"Pascussi","year":"2005","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.bbadis.2011.01.014_bb0665","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1172\/JCI27793","article-title":"Steroid and xenobiotic receptor and vitamin D receptor crosstalk mediates CYP24 expression and drug-induced osteomalacia","volume":"116","author":"Zhou","year":"2006","journal-title":"J. Clin. Invest."},{"issue":"5727","key":"10.1016\/j.bbadis.2011.01.014_bb0670","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1136\/bmj.4.5727.69","article-title":"Osteomalacia with long-term anticonvulsant therapy in epilepsy","volume":"4","author":"Dent","year":"1970","journal-title":"Br. Med. J."},{"issue":"3","key":"10.1016\/j.bbadis.2011.01.014_bb0675","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0041-3879(81)90008-8","article-title":"Rifampicin induced osteomalacia","volume":"62","author":"Shah","year":"1981","journal-title":"Tubercle"},{"issue":"2","key":"10.1016\/j.bbadis.2011.01.014_bb0680","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/S0891-5849(01)00574-3","article-title":"Tocopherols are metabolized in HepG2 cells by side chain omega-oxidation and consecutive beta-oxidation","volume":"31","author":"Birringer","year":"2001","journal-title":"Free Radic. Biol. Med."},{"issue":"4","key":"10.1016\/j.bbadis.2011.01.014_bb0685","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S0022-2275(20)32145-3","article-title":"Urinary excretion of 2, 7, 8-trimethyl-2-(beta-carboxyethyl)-6-hydroxychroman is a major route of elimination of gamma-tocopherol in humans","volume":"40","author":"Swanson","year":"1999","journal-title":"J. Lipid Res."},{"issue":"2","key":"10.1016\/j.bbadis.2011.01.014_bb0690","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1006\/abio.1999.4312","article-title":"Quantification of the alpha- and gamma-tocopherol metabolites 2,5,7,8-tetramethyl-2-(2\u2032-carboxyethyl)-6-hydroxychroman and 2,7,8-trimethyl-2-(2\u2032-carboxyethyl)-6-hydroxychroman in human serum","volume":"275","author":"Stahl","year":"1999","journal-title":"Anal. Biochem."},{"issue":"10","key":"10.1016\/j.bbadis.2011.01.014_bb0695","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1096\/fasebj.13.10.1145","article-title":"Vitamin E: function and metabolism","volume":"13","author":"Brigelius-Flohe","year":"1999","journal-title":"FASEB J."},{"issue":"5","key":"10.1016\/j.bbadis.2011.01.014_bb0700","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s11745-001-0744-2","article-title":"Alpha-tocopherol affects the urinary and biliary excretion of 2,7,8-trimethyl-2(2\u2032-carboxyethyl)-6-hydroxychroman, gamma-tocopherol metabolite, in rats","volume":"36","author":"Kiyose","year":"2001","journal-title":"Lipids"},{"issue":"2","key":"10.1016\/j.bbadis.2011.01.014_bb0705","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0006-2952(02)01520-4","article-title":"Vitamin E activates gene expression via the pregnane X receptor","volume":"65","author":"Landes","year":"2003","journal-title":"Biochem. Pharmacol."},{"issue":"3","key":"10.1016\/j.bbadis.2011.01.014_bb0710","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0006-291X(03)00811-8","article-title":"Vitamin E and drug metabolism","volume":"305","author":"Brigelius-Flohe","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"10","key":"10.1016\/j.bbadis.2011.01.014_bb0715","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1172\/JCI2887","article-title":"CCAAT\/enhancer binding protein epsilon is a potential retinoid target gene in acute promyelocytic leukemia treatment","volume":"103","author":"Park","year":"1999","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.bbadis.2011.01.014_bb0720","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/89050","article-title":"Retinoic acid-induced apoptosis in leukemia cells is mediated by paracrine action of tumor-selective death ligand TRAIL","volume":"7","author":"Altucci","year":"2001","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbadis.2011.01.014_bb0725","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1146\/annurev.nutr.24.012003.132407","article-title":"Retinoic acid receptors and cancers","volume":"24","author":"Soprano","year":"2004","journal-title":"Annu. Rev. Nutr."},{"issue":"2","key":"10.1016\/j.bbadis.2011.01.014_bb0730","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1124\/jpet.107.131045","article-title":"Role of pregnane X receptor in control of all-trans retinoic acid (ATRA) metabolism and its potential contribution to ATRA resistance","volume":"324","author":"Wang","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"26","key":"10.1016\/j.bbadis.2011.01.014_bb0735","doi-asserted-by":"crossref","first-page":"17882","DOI":"10.1074\/jbc.M601302200","article-title":"Role of NF-kappaB in regulation of PXR-mediated gene expression: a mechanism for the suppression of cytochrome P-450 3A4 by proinflammatory agents","volume":"281","author":"Gu","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.bbadis.2011.01.014_bb0740","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1124\/jpet.104.076141","article-title":"The involvement of the pregnane X receptor in hepatic gene regulation during inflammation in mice","volume":"312","author":"Teng","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"1","key":"10.1016\/j.bbadis.2011.01.014_bb0745","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0006-291X(02)00196-1","article-title":"Reduction in cytochrome P-450 enzyme expression is associated with repression of CAR (constitutive androstane receptor) and PXR (pregnane X receptor) in mouse liver during the acute phase response","volume":"293","author":"Beigneux","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"8","key":"10.1016\/j.bbadis.2011.01.014_bb0750","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1172\/JCI26283","article-title":"Mutual repression between steroid and xenobiotic receptor and NF-kappaB signaling pathways links xenobiotic metabolism and inflammation","volume":"116","author":"Zhou","year":"2006","journal-title":"J. Clin. Invest."},{"issue":"11","key":"10.1016\/j.bbadis.2011.01.014_bb0755","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1177\/0091270006292125","article-title":"Human pregnane X receptor: genetic polymorphisms, alternative mRNA splice variants, and cytochrome P450 3A metabolic activity","volume":"46","author":"He","year":"2006","journal-title":"J. Clin. Pharmacol."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443911000275?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443911000275?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T05:09:33Z","timestamp":1740892173000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443911000275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":151,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["S0925443911000275"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2011.01.014","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2011,8]]}}}