{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T04:59:18Z","timestamp":1780981158733,"version":"3.54.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":630,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Helmholtz Virtual institute GeNeSys"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1016\/j.bbadis.2011.09.003","type":"journal-article","created":{"date-parts":[[2011,9,11]],"date-time":"2011-09-11T23:56:13Z","timestamp":1315785373000},"page":"1640-1648","source":"Crossref","is-referenced-by-count":6,"title":["Expression of the megalin C-terminal fragment by macrophages during liver fibrogenesis in mice"],"prefix":"10.1016","volume":"1812","author":[{"given":"Ursula","family":"Pieper-F\u00fcrst","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabea","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Huss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Hochrath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Peter","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Tacke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Weiskirchen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Lammert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2011.09.003_bb0005","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1136\/gut.46.4.443","article-title":"Is liver fibrosis reversible?","volume":"46","author":"Benyon","year":"2000","journal-title":"Gut"},{"key":"10.1016\/j.bbadis.2011.09.003_bb0010","doi-asserted-by":"crossref","first-page":"D69","DOI":"10.2741\/887","article-title":"Liver fibrosis: signals leading to the amplification of the fibrogenic hepatic stellate cell","volume":"8","author":"G\u00e4bele","year":"2003","journal-title":"Front. Biosci."},{"key":"10.1016\/j.bbadis.2011.09.003_bb0015","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2011.09.003_bb0020","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1111\/j.1478-3231.2006.01342.x","article-title":"Role of Kupffer cells in host defense and liver disease","volume":"26","author":"Bilzer","year":"2006","journal-title":"Liver Int."},{"key":"10.1016\/j.bbadis.2011.09.003_bb0025","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/hep.22950","article-title":"Hepatic recruitment of the inflammatory Gr1+ monocyte subset upon liver injury promotes hepatic fibrosis","volume":"50","author":"Karlmark","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.bbadis.2011.09.003_bb0030","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/nrg2025","article-title":"The mouse as a model for human biology: a resource guide for complex trait analysis","volume":"8","author":"Peters","year":"2007","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.bbadis.2011.09.003_bb0035","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1053\/gast.2002.37069","article-title":"Genome-wide analysis of hepatic fibrosis in inbred mice identifies the susceptibility locus Hfib1 on chromosome 15","volume":"123","author":"Hillebrandt","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbadis.2011.09.003_bb0040","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/ng1599","article-title":"Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans","volume":"37","author":"Hillebrandt","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbadis.2011.09.003_bb0045","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s00335-010-9273-7","article-title":"SYSGENET consortium, SYSGENET: a meeting report from a new European network for systems genetics","volume":"21","author":"Schughart","year":"2010","journal-title":"Mamm. Genome"},{"key":"10.1016\/j.bbadis.2011.09.003_bb0050","doi-asserted-by":"crossref","first-page":"9725","DOI":"10.1073\/pnas.91.21.9725","article-title":"Complete cloning and sequencing of rat gp330\/\u201cmegalin\u201d, a distinctive member of the low density lipoprotein receptor gene family","volume":"91","author":"Saito","year":"1994","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bbadis.2011.09.003_bb0055","doi-asserted-by":"crossref","first-page":"5557","DOI":"10.1073\/pnas.79.18.5557","article-title":"The pathogenic antigen of Heymann nephritis is a membrane glycoprotein of the renal proximal tubule brush border","volume":"79","author":"Kerjaschki","year":"1982","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bbadis.2011.09.003_bb0060","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1177\/42.4.7510321","article-title":"Organ distribution in rats of two members of the low-density lipoprotein receptor gene family, gp330 and LRP\/\u03b12MR, and the receptor-associated protein (RAP)","volume":"42","author":"Zheng","year":"1994","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.bbadis.2011.09.003_bb0065","doi-asserted-by":"crossref","first-page":"E900","DOI":"10.1152\/ajpendo.2001.281.5.E900","article-title":"Cubilin and megalin expression and their interaction in the rat intestine: effect of thyroidectomy","volume":"281","author":"Yammani","year":"2001","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.bbadis.2011.09.003_bb0070","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1194\/jlr.M400235-JLR200","article-title":"Megalin and cubilin expression in gallbladder epithelium and regulation by bile acids","volume":"45","author":"Erranz","year":"2004","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbadis.2011.09.003_bb0075","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.modgep.2005.04.014","article-title":"Overlapping expression patterns of the multiligand endocytic receptors cubilin and megalin in the CNS, sensory organs and developing epithelia of the rodent embryo","volume":"6","author":"Ass\u00e9mat","year":"2005","journal-title":"Gene Expr. Patterns"},{"key":"10.1016\/j.bbadis.2011.09.003_bb0080","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/nrm778","article-title":"Megalin and cubilin: multifunctional endocytic receptors","volume":"3","author":"Christensen","year":"2002","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbadis.2011.09.003_bb0085","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1126\/science.2786251","article-title":"Autoimmune target of Heymann nephritis is a glycoprotein with homology to the LDL receptor","volume":"244","author":"Raychowdhury","year":"1989","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2011.09.003_bb0090","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/326760a0","article-title":"Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region","volume":"326","author":"Davis","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2011.09.003_bb0095","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.1016\/S0021-9258(19)39742-X","article-title":"NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor","volume":"265","author":"Chen","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2011.09.003_bb0100","doi-asserted-by":"crossref","first-page":"C1105","DOI":"10.1152\/ajpcell.00514.2002","article-title":"Identification of an apical sorting determinant in the cytoplasmic tail of megalin","volume":"284","author":"Takeda","year":"2003","journal-title":"Am. J. Cell Physiol."},{"key":"10.1016\/j.bbadis.2011.09.003_bb0105","doi-asserted-by":"crossref","first-page":"34302","DOI":"10.1074\/jbc.M405608200","article-title":"Linking receptor-mediated endocytosis and cell signaling","volume":"279","author":"Zou","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2011.09.003_bb0110","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1038\/sj.ki.5000298","article-title":"Regulated intramembrane proteolysis of megalin: linking urinary protein and gene regulation in proximal tubule?","volume":"69","author":"Biemesderfer","year":"2006","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbadis.2011.09.003_bb0115","doi-asserted-by":"crossref","first-page":"18736","DOI":"10.1074\/jbc.M201979200","article-title":"Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain","volume":"277","author":"May","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2011.09.003_bb0120","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/30756","article-title":"Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain","volume":"393","author":"Schroeter","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2011.09.003_bb0125","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1001\/jama.1997.03540340059034","article-title":"Exploring the etiology of Alzheimer disease using molecular genetics","volume":"277","author":"Lendon","year":"1997","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.bbadis.2011.09.003_bb0130","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1042\/0264-6021:3470613","article-title":"Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600\/megalin","volume":"347","author":"Oleinikov","year":"2000","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbadis.2011.09.003_bb0135","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1242\/jcs.00243","article-title":"Functional interaction of megalin with the megalin-binding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule","volume":"116","author":"Petersen","year":"2003","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbadis.2011.09.003_bb0210","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1136\/gut.2010.209551","article-title":"Absence of hepatic stellate cell retinoid lipid droplets does not enhance hepatic fibrosis but decreases hepatic carcinogenesis","volume":"60","author":"Kluwe","year":"2011","journal-title":"Gut"},{"key":"10.1016\/j.bbadis.2011.09.003_bb0145","first-page":"481","article-title":"Approved recommendation (1985) on IFCC methods. Part 3. IFCC method for alanine aminotransferase","volume":"24","author":"Bergmeyer","year":"1986","journal-title":"J. Clin. Chem. Clin. Biochem."},{"key":"10.1016\/j.bbadis.2011.09.003_bb0150","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-2697(81)90261-X","article-title":"A simple method to determine nanogram levels of 4-hydroxyproline in biological tissues","volume":"112","author":"Jamall","year":"1981","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bbadis.2011.09.003_bb0155","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/emboj\/16.2.211","article-title":"Molecular structure of the sarcomeric M band: mapping of titin and myosin binding domains in myomesin and the identification of a potential regulatory phosphorylation site in myomesin","volume":"16","author":"Obermann","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/j.bbadis.2011.09.003_bb0160","doi-asserted-by":"crossref","first-page":"11955","DOI":"10.1016\/S0021-9258(18)43211-5","article-title":"Affinity purification of antibodies from diazotized paper blots of heterogenous protein samples","volume":"256","author":"Olmstedt","year":"1981","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2011.09.003_bb0165","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2011.09.003_bb0170","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1002\/hep.23894","article-title":"The fractalkine receptor CX3CR1 protects against liver fibrosis by controlling differentiation and survival of infiltrating hepatic monocytes","volume":"52","author":"Karlmark","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.bbadis.2011.09.003_bb0175","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1002\/eji.1830111013","article-title":"F4\/80, a monoclonal antibody directed specifically against the mouse macrophage","volume":"11","author":"Austyn","year":"1981","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.bbadis.2011.09.003_bb0180","first-page":"59","article-title":"An improved and cost-effective methodology for the reduction of autofluorescence in direct immunofluorescence studies on formalin-fixed paraffin-embedded tissues","volume":"51","author":"Viegas","year":"2007","journal-title":"Eur. J. Histochem."},{"key":"10.1016\/j.bbadis.2011.09.003_bb0185","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1055\/s-2006-927395","article-title":"Inflammation, damage repair and liver fibrosis \u2014 role of cytokines and different cell types","volume":"45","author":"Saile","year":"2007","journal-title":"Z. Gastroenterol."},{"key":"10.1016\/j.bbadis.2011.09.003_bb0190","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.cca.2007.12.011","article-title":"Gc-globulin (vitamin D binding protein) is synthesized and secreted by hepatocytes and internalized by hepatic stellate cells through Ca2+dependent interaction with the megalin\/gp330 receptor","volume":"390","author":"Gressner","year":"2008","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.bbadis.2011.09.003_bb0195","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1111\/j.1753-4887.1998.tb01643.x","article-title":"The role of vitamin A and related retinoids in immune function","volume":"56","author":"Semba","year":"1998","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.bbadis.2011.09.003_bb0200","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1046\/j.1440-1746.2002.02804.x","article-title":"High, but not low, dietary retinoids aggravate manifestation of rat liver fibrosis","volume":"17","author":"Vollmar","year":"2002","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbadis.2011.09.003_bb0205","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0955-2863(99)00013-3","article-title":"Uptake of vitamin A in macrophages from physiologic transport proteins: role of retinol-binding protein and chylomicron remnants","volume":"10","author":"Hagen","year":"1999","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.bbadis.2011.09.003_bb0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/scisignal.1164263","article-title":"\u03b3-secretase limits the inflammatory response through the processing of LRP1","volume":"1","author":"Zurhove","year":"2008","journal-title":"Sci. Signal."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443911001980?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443911001980?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,12,4]],"date-time":"2021-12-04T09:47:14Z","timestamp":1638611234000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443911001980"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":42,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["S0925443911001980"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2011.09.003","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2011,12]]}}}