{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T04:49:34Z","timestamp":1783745374929,"version":"3.55.0"},"reference-count":190,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":478,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1016\/j.bbadis.2011.11.004","type":"journal-article","created":{"date-parts":[[2011,11,10]],"date-time":"2011-11-10T05:28:35Z","timestamp":1320902915000},"page":"714-728","source":"Crossref","is-referenced-by-count":89,"title":["Pharmacological antioxidant strategies as therapeutic interventions for COPD"],"prefix":"10.1016","volume":"1822","author":[{"given":"Irfan","family":"Rahman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2011.11.004_bb0005","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.bcp.2004.05.042","article-title":"Redox modulation of chromatin remodeling: impact on histone acetylation and deacetylation, NF-kappaB and pro-inflammatory gene expression","volume":"68","author":"Rahman","year":"2004","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0010","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.taap.2009.10.022","article-title":"Current concepts on oxidative\/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease","volume":"254","author":"Yao","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0015","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.mam.2008.07.001","article-title":"Environmental toxicity, redox signaling and lung inflammation: the role of glutathione","volume":"30","author":"Biswas","year":"2009","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0020","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1177\/1753465808098224","article-title":"Antioxidant therapeutic advances in COPD","volume":"2","author":"Rahman","year":"2008","journal-title":"Ther. Adv. Respir. Dis."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0025","first-page":"15","article-title":"Antioxidant therapies in COPD","volume":"1","author":"Rahman","year":"2006","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0030","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1183\/09031936.06.00053805","article-title":"Oxidative stress and redox regulation of lung inflammation in COPD","volume":"28","author":"Rahman","year":"2006","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0035","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1136\/thx.2006.072777","article-title":"Characterisation of phenotypes based on severity of emphysema in chronic obstructive pulmonary disease","volume":"62","author":"Makita","year":"2007","journal-title":"Thorax"},{"key":"10.1016\/j.bbadis.2011.11.004_bb0040","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1513\/pats.200603-087MS","article-title":"Airway and parenchymal disease in chronic obstructive pulmonary disease are distinct phenotypes","volume":"3","author":"Patel","year":"2006","journal-title":"Proc. Am. Thorac. Soc."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0045","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1289\/ehp.8564111","article-title":"Free-radical chemistry of cigarette smoke and its toxicological implications","volume":"64","author":"Church","year":"1985","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0050","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0891-5849(89)90094-4","article-title":"Quantitative analysis of the hydrogen peroxide formed in aqueous cigarette tar extracts","volume":"7","author":"Nakayama","year":"1989","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0055","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1749-6632.1993.tb39148.x","article-title":"Oxidants in cigarette smoke. Radicals, hydrogen peroxide, peroxynitrate, and peroxynitrite","volume":"686","author":"Pryor","year":"1993","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0060","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1164\/ajrccm.163.2.2003122","article-title":"Granulocyte inflammatory markers and airway infection during acute exacerbation of chronic obstructive pulmonary disease","volume":"163","author":"Aaron","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0065","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1136\/thorax.56.1.36","article-title":"Relationship between airway inflammation and the frequency of exacerbations in patients with smoking related COPD","volume":"56","author":"Gompertz","year":"2001","journal-title":"Thorax"},{"key":"10.1016\/j.bbadis.2011.11.004_bb0070","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/S0891-5849(98)00128-2","article-title":"Detection of xanthine oxidase activity products by EPR and HPLC in bronchoalveolar lavage fluid from patients with chronic obstructive pulmonary disease","volume":"25","author":"Pinamonti","year":"1998","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0075","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1089\/ars.2008.2063","article-title":"Thiol chemistry in peroxidase catalysis and redox signaling","volume":"10","author":"Bindoli","year":"2008","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0080","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1164\/ajrccm.162.3.2001063","article-title":"Exhaled 8-isoprostane as an in vivo biomarker of lung oxidative stress in patients with COPD and healthy smokers","volume":"162","author":"Montuschi","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0085","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1164\/rccm.2110101","article-title":"4-Hydroxy-2-nonenal, a specific lipid peroxidation product, is elevated in lungs of patients with chronic obstructive pulmonary disease","volume":"166","author":"Rahman","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0090","doi-asserted-by":"crossref","first-page":"L839","DOI":"10.1152\/ajplung.90570.2008","article-title":"alpha, beta-Unsaturated aldehydes contained in cigarette smoke elicit IL-8 release in pulmonary cells through mitogen-activated protein kinases","volume":"296","author":"Moretto","year":"2009","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0095","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1164\/ajrccm.154.4.8887607","article-title":"Systemic oxidative stress in asthma, COPD, and smokers","volume":"154","author":"Rahman","year":"1996","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0100","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/S0891-5849(00)00215-X","article-title":"Regulation of redox glutathione levels and gene transcription in lung inflammation: therapeutic approaches","volume":"28","author":"Rahman","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0105","doi-asserted-by":"crossref","first-page":"264","DOI":"10.3109\/15412555.2011.579202","article-title":"Plasma Antioxidants Are Associated with Impaired Lung Function and COPD Exacerbations in Smokers","volume":"8","author":"Nicks","year":"2011","journal-title":"COPD"},{"key":"10.1016\/j.bbadis.2011.11.004_bb0110","doi-asserted-by":"crossref","first-page":"e8225","DOI":"10.1371\/journal.pone.0008225","article-title":"Cigarette smoking blocks the protective expression of Nrf2\/ARE pathway in peripheral mononuclear cells of young heavy smokers favouring inflammation","volume":"4","author":"Garbin","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2011.11.004_bb0115","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.ejphar.2005.12.087","article-title":"Oxidant and antioxidant balance in the airways and airway diseases","volume":"533","author":"Rahman","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0120","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1165\/rcmb.2002-0228OC","article-title":"Oxidative stress and apoptosis interact and cause emphysema due to vascular endothelial growth factor receptor blockade","volume":"29","author":"Tuder","year":"2003","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0125","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1124\/jpet.104.068205","article-title":"The protective effect of superoxide dismutase mimetic M40401 on balloon injury-related neointima formation: role of the lectin-like oxidized low-density lipoprotein receptor-1","volume":"311","author":"Muscoli","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0130","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0891-5849(02)00919-X","article-title":"Inhibition of airway inflammation and hyperreactivity by an antioxidant mimetic","volume":"33","author":"Chang","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0135","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/S0891-5849(02)01003-1","article-title":"Inhibition of tobacco smoke-induced lung inflammation by a catalytic antioxidant","volume":"33","author":"Smith","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0140","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1042\/bj20020154","article-title":"Oxidation of nitric oxide by oxomanganese-salen complexes: a new mechanism for cellular protection by superoxide dismutase\/catalase mimetics","volume":"366","author":"Sharpe","year":"2002","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0145","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1165\/ajrcmb.20.2.3305","article-title":"Superoxide mediates cigarette smoke-induced infiltration of neutrophils into the airways through nuclear factor-kappaB activation and IL-8 mRNA expression in guinea pigs in vivo","volume":"20","author":"Nishikawa","year":"1999","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0150","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/S0022-3565(25)12174-5","article-title":"A metalloporphyrin superoxide dismutase mimetic protects against paraquat-induced endothelial cell injury, in vitro","volume":"275","author":"Day","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0155","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1006\/abbi.1997.0341","article-title":"Manganic porphyrins possess catalase activity and protect endothelial cells against hydrogen peroxide-mediated injury","volume":"347","author":"Day","year":"1997","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0160","doi-asserted-by":"crossref","first-page":"27432","DOI":"10.1074\/jbc.M213302200","article-title":"Reactions of manganese porphyrins with peroxynitrite and carbonate radical anion","volume":"278","author":"Ferrer-Sueta","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0165","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.freeradbiomed.2003.10.029","article-title":"Mechanistic analysis of the immunomodulatory effects of a catalytic antioxidant on antigen-presenting cells: implication for their use in targeting oxidation-reduction reactions in innate immunity","volume":"36","author":"Tse","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0170","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0891-5849(02)00980-2","article-title":"A small molecular weight catalytic metalloporphyrin antioxidant with superoxide dismutase (SOD) mimetic properties protects lungs from radiation-induced injury","volume":"33","author":"Vujaskovic","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0175","doi-asserted-by":"crossref","first-page":"347","DOI":"10.2337\/diabetes.51.2.347","article-title":"A metalloporphyrin-based superoxide dismutase mimic inhibits adoptive transfer of autoimmune diabetes by a diabetogenic T-cell clone","volume":"51","author":"Piganelli","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2011.11.004_bb0180","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1096\/fj.04-1629fje","article-title":"Redox modulation of the liver with chronic antioxidant enzyme mimetic treatment prevents age-related oxidative damage associated with environmental stress","volume":"18","author":"Zhang","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0185","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1152\/japplphysiol.01046.2005","article-title":"Chronic antioxidant enzyme mimetic treatment differentially modulates hyperthermia-induced liver HSP70 expression with aging","volume":"100","author":"Zhang","year":"2006","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0190","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1164\/rccm.200506-850OC","article-title":"Superoxide dismutase expression attenuates cigarette smoke- or elastase-generated emphysema in mice","volume":"173","author":"Foronjy","year":"2006","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0195","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1016\/j.freeradbiomed.2010.09.028","article-title":"Sustained lung activity of a novel chimeric protein, SOD2\/3, after intratracheal administration","volume":"49","author":"Clarke","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0200","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1164\/rccm.200212-1479SO","article-title":"Superoxide dismutases in the lung and human lung diseases","volume":"167","author":"Kinnula","year":"2003","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0205","doi-asserted-by":"crossref","first-page":"915","DOI":"10.2353\/ajpath.2008.080119","article-title":"Loss of extracellular superoxide dismutase leads to acute lung damage in the presence of ambient air: a potential mechanism underlying adult respiratory distress syndrome","volume":"173","author":"Gongora","year":"2008","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0210","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1172\/JCI3816","article-title":"Extracellular superoxide dismutase in the airways of transgenic mice reduces inflammation and attenuates lung toxicity following hyperoxia","volume":"103","author":"Folz","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0215","doi-asserted-by":"crossref","first-page":"15571","DOI":"10.1073\/pnas.1007625107","article-title":"Extracellular superoxide dismutase protects against pulmonary emphysema by attenuating oxidative fragmentation of ECM","volume":"107","author":"Yao","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0220","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1016\/j.freeradbiomed.2010.09.022","article-title":"Endogenous enzymes (NOX and ECSOD) regulate smoke-induced oxidative stress","volume":"49","author":"Tollefson","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0225","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.freeradbiomed.2011.05.008","article-title":"Smoking and COPD increase sputum levels of extracellular superoxide dismutase","volume":"51","author":"Regan","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0230","doi-asserted-by":"crossref","first-page":"262","DOI":"10.3109\/15412555.2010.496821","article-title":"Polymorphisms in the superoxide dismutase-3 gene are associated with emphysema in COPD","volume":"7","author":"Sorheim","year":"2010","journal-title":"COPD"},{"key":"10.1016\/j.bbadis.2011.11.004_bb0235","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1164\/rccm.200804-549OC","article-title":"Superoxide dismutase 3 polymorphism associated with reduced lung function in two large populations","volume":"178","author":"Dahl","year":"2008","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0240","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/S0891-5849(03)00439-8","article-title":"Selenium-containing compounds attenuate peroxynitrite-mediated NF-kappaB and AP-1 activation and interleukin-8 gene and protein expression in human leukocytes","volume":"35","author":"Jozsef","year":"2003","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0245","doi-asserted-by":"crossref","first-page":"974","DOI":"10.4049\/jimmunol.169.2.974","article-title":"Differential effects of ebselen on neutrophil recruitment, chemokine, and inflammatory mediator expression in a rat model of lipopolysaccharide-induced pulmonary inflammation","volume":"169","author":"Haddad el","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0250","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/S0891-5849(01)00825-5","article-title":"Ebselen suppresses late airway responses and airway inflammation in guinea pigs","volume":"32","author":"Zhang","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0255","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/S0891-5849(98)00038-0","article-title":"Glutathione peroxidase mimics prevent TNFalpha- and neutrophil-induced endothelial alterations","volume":"25","author":"Moutet","year":"1998","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0260","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1203\/PDR.0b013e31806790c0","article-title":"Peroxynitrite decomposition catalyst FeTMPyP provides partial protection against intestinal ischemia and reperfusion injury in infant rats","volume":"62","author":"Stefanutti","year":"2007","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0265","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1161\/01.CIR.0000048192.52098.DD","article-title":"Potent metalloporphyrin peroxynitrite decomposition catalyst protects against the development of doxorubicin-induced cardiac dysfunction","volume":"107","author":"Pacher","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.bbadis.2011.11.004_bb0270","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.2174\/0929867043365396","article-title":"Potential therapeutic effect of antioxidant therapy in shock and inflammation","volume":"11","author":"Cuzzocrea","year":"2004","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0275","doi-asserted-by":"crossref","first-page":"10824","DOI":"10.1073\/pnas.96.19.10824","article-title":"BN 80933, a dual inhibitor of neuronal nitric oxide synthase and lipid peroxidation: a promising neuroprotective strategy","volume":"96","author":"Chabrier","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0280","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.abb.2005.02.028","article-title":"Evaluation of spin trapping agents and trapping conditions for detection of cell-generated reactive oxygen species","volume":"437","author":"Shi","year":"2005","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0285","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1007\/s000180050457","article-title":"Diagnostic and therapeutic applications of azulenyl nitrone spin traps","volume":"56","author":"Becker","year":"1999","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0290","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1039\/b300642e","article-title":"Synthesis and EPR spin trapping properties of a new isoindole-based nitrone: 1,1,3-trimethylisoindole N-oxide (TMINO)","volume":"1","author":"Bottle","year":"2003","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0295","doi-asserted-by":"crossref","first-page":"4678","DOI":"10.1021\/ja011507s","article-title":"Stilbazulenyl nitrone (STAZN): a nitronyl-substituted hydrocarbon with the potency of classical phenolic chain-breaking antioxidants","volume":"124","author":"Becker","year":"2002","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0300","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.pupt.2011.05.006","article-title":"L-NAME and L-arginine differentially ameliorate cigarette smoke-induced emphysema in mice","volume":"24","author":"Valenca","year":"2011","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0305","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.cell.2011.08.035","article-title":"Inducible NOS Inhibition Reverses Tobacco-Smoke-Induced Emphysema and Pulmonary Hypertension in Mice","volume":"147","author":"Seimetz","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2011.11.004_bb0310","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1146\/annurev.pharmtox.46.120604.141046","article-title":"Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway","volume":"47","author":"Kensler","year":"2007","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0315","doi-asserted-by":"crossref","first-page":"4147","DOI":"10.1021\/jm2002348","article-title":"Novel chalcone derivatives as potent Nrf2 activators in mice and human lung epithelial cells","volume":"54","author":"Kumar","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0320","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1084\/jem.20050538","article-title":"Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice","volume":"202","author":"Rangasamy","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0325","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1073\/pnas.0804333106","article-title":"Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice","volume":"106","author":"Sussan","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0330","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1080\/08958370701496145","article-title":"Antioxidant enzyme induction: a new protective approach against the adverse effects of diesel exhaust particles","volume":"19","author":"Wan","year":"2007","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0335","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1165\/rcmb.2005-0325OC","article-title":"Glutathione peroxidase 2, the major cigarette smoke-inducible isoform of GPX in lungs, is regulated by Nrf2","volume":"35","author":"Singh","year":"2006","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0340","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1172\/JCI200421146","article-title":"Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice","volume":"114","author":"Rangasamy","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0345","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1111\/j.1365-2443.2005.00905.x","article-title":"Nrf2-deficient mice are highly susceptible to cigarette smoke-induced emphysema","volume":"10","author":"Iizuka","year":"2005","journal-title":"Genes Cells"},{"key":"10.1016\/j.bbadis.2011.11.004_bb0350","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1136\/thx.2007.091181","article-title":"Altered Nrf2\/Keap1-Bach1 equilibrium in pulmonary emphysema","volume":"63","author":"Goven","year":"2008","journal-title":"Thorax"},{"key":"10.1016\/j.bbadis.2011.11.004_bb0355","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1164\/rccm.200803-380OC","article-title":"Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1","volume":"178","author":"Malhotra","year":"2008","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0360","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1165\/rcmb.2007-0424OC","article-title":"Down-regulated NF-E2-related factor 2 in pulmonary macrophages of aged smokers and patients with chronic obstructive pulmonary disease","volume":"39","author":"Suzuki","year":"2008","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0365","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.bbrc.2011.02.035","article-title":"Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress","volume":"406","author":"Mercado","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0370","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.bbrc.2010.11.054","article-title":"Nrf2 deficiency influences susceptibility to steroid resistance via HDAC2 reduction","volume":"403","author":"Adenuga","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0375","doi-asserted-by":"crossref","first-page":"L46","DOI":"10.1152\/ajplung.00241.2005","article-title":"Cigarette smoke induces proinflammatory cytokine release by activation of NF-kappaB and posttranslational modifications of histone deacetylase in macrophages","volume":"291","author":"Yang","year":"2006","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0380","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1165\/rcmb.2008-0012OC","article-title":"Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2","volume":"39","author":"Meja","year":"2008","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0385","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1165\/rcmb.2008-0255OC","article-title":"Histone deacetylase 2 is phosphorylated, ubiquitinated, and degraded by cigarette smoke","volume":"40","author":"Adenuga","year":"2009","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0390","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.bbrc.2009.04.128","article-title":"Nitration of distinct tyrosine residues causes inactivation of histone deacetylase 2","volume":"384","author":"Osoata","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0395","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nature07238","article-title":"S-Nitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons","volume":"455","author":"Nott","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2011.11.004_bb0400","doi-asserted-by":"crossref","first-page":"4289","DOI":"10.1172\/JCI45144","article-title":"Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients","volume":"121","author":"Malhotra","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0405","doi-asserted-by":"crossref","first-page":"17417","DOI":"10.1074\/jbc.M109.089250","article-title":"Redox signaling, alkylation (carbonylation) of conserved cysteines inactivates class I histone deacetylases 1, 2, and 3 and antagonizes their transcriptional repressor function","volume":"285","author":"Doyle","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0410","first-page":"5196","article-title":"Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray","volume":"62","author":"Thimmulappa","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0415","doi-asserted-by":"crossref","first-page":"8135","DOI":"10.1074\/jbc.M211898200","article-title":"Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival","volume":"278","author":"Kwak","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0420","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1042\/bj20021619","article-title":"Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element","volume":"371","author":"Balogun","year":"2003","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0425","doi-asserted-by":"crossref","first-page":"481","DOI":"10.2174\/0929867053363153","article-title":"Chalcones: an update on cytotoxic and chemoprotective properties","volume":"12","author":"Go","year":"2005","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0430","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.ejmech.2006.12.009","article-title":"Synthetic 2',5'-dimethoxychalcones as G(2)\/M arrest-mediated apoptosis-inducing agents and inhibitors of nitric oxide production in rat macrophages","volume":"42","author":"Wei","year":"2007","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0435","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1124\/jpet.105.092486","article-title":"Blockade of nuclear factor-kappaB signaling pathway and anti-inflammatory activity of cardamomin, a chalcone analog from Alpinia conchigera","volume":"316","author":"Lee","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0440","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1016\/j.lfs.2006.12.040","article-title":"Chalcone inhibits the activation of NF-kappaB and STAT3 in endothelial cells via endogenous electrophile","volume":"80","author":"Liu","year":"2007","journal-title":"Life Sci."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0445","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1124\/jpet.104.074153","article-title":"Differential activation of heme oxygenase-1 by chalcones and rosolic acid in endothelial cells","volume":"312","author":"Foresti","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0450","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.cellsig.2004.11.016","article-title":"Direct association of hepatopoietin with thioredoxin constitutes a redox signal transduction in activation of AP-1\/NF-kappaB","volume":"17","author":"Li","year":"2005","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0455","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1093\/emboj\/17.9.2596","article-title":"Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1","volume":"17","author":"Saitoh","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0460","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0969-2126(01)00159-9","article-title":"Solution structure of human thioredoxin in a mixed disulfide intermediate complex with its target peptide from the transcription factor NF kappa B","volume":"3","author":"Qin","year":"1995","journal-title":"Structure"},{"key":"10.1016\/j.bbadis.2011.11.004_bb0465","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/sj.bjp.0706190","article-title":"NF-kappaB plays a major role during the systemic and local acute inflammatory response following intestinal reperfusion injury","volume":"145","author":"Souza","year":"2005","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0470","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1073\/pnas.0437889100","article-title":"Chemogenomic identification of Ref-1\/AP-1 as a therapeutic target for asthma","volume":"100","author":"Nguyen","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0475","doi-asserted-by":"crossref","first-page":"5294","DOI":"10.4049\/jimmunol.169.9.5294","article-title":"A small molecule inhibitor of redox-regulated NF-kappa B and activator protein-1 transcription blocks allergic airway inflammation in a mouse asthma model","volume":"169","author":"Henderson","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0480","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1124\/jpet.107.134007","article-title":"Thioredoxin-1 ameliorates cigarette smoke-induced lung inflammation and emphysema in mice","volume":"325","author":"Sato","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0485","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/j.freeradbiomed.2011.02.026","article-title":"Alleviation of oxidative stress by potent and selective thioredoxin-mimetic peptides","volume":"50","author":"Bachnoff","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0490","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1515\/BC.2002.040","article-title":"Peroxiredoxins","volume":"383","author":"Hofmann","year":"2002","journal-title":"Biol. Chem."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0495","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0968-0004(02)00003-8","article-title":"Structure, mechanism and regulation of peroxiredoxins","volume":"28","author":"Wood","year":"2003","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0500","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/S0014-5793(03)01199-2","article-title":"1-Cys peroxiredoxin knock-out mice express mRNA but not protein for a highly related intronless gene","volume":"555","author":"Mo","year":"2003","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0505","first-page":"L750","article-title":"Cloning and expression of rat lung acidic Ca(2+)-independent PLA2 and its organ distribution","volume":"274","author":"Kim","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0510","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s10059-009-0152-6","article-title":"Peroxiredoxin 6 promotes lung cancer cell invasion by inducing urokinase-type plasminogen activator via p38 kinase, phosphoinositide 3-kinase, and Akt","volume":"28","author":"Lee","year":"2009","journal-title":"Mol. Cells"},{"key":"10.1016\/j.bbadis.2011.11.004_bb0515","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/nature01819","article-title":"Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression","volume":"424","author":"Neumann","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2011.11.004_bb0520","doi-asserted-by":"crossref","first-page":"451","DOI":"10.3109\/01902141003754128","article-title":"Peroxiredoxin 6 differentially regulates acute and chronic cigarette smoke-mediated lung inflammatory response and injury","volume":"36","author":"Sundar","year":"2010","journal-title":"Exp. Lung Res."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0525","doi-asserted-by":"crossref","first-page":"L192","DOI":"10.1152\/ajplung.00426.2009","article-title":"Glutaredoxin 1 regulates cigarette smoke-mediated lung inflammation through differential modulation of I{kappa}B kinases in mice: impact on histone acetylation","volume":"299","author":"Chung","year":"2010","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0530","doi-asserted-by":"crossref","first-page":"13086","DOI":"10.1073\/pnas.0603290103","article-title":"Dynamic redox control of NF-kappaB through glutaredoxin-regulated S-glutathionylation of inhibitory kappaB kinase beta","volume":"103","author":"Reynaert","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0535","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/1465-9921-7-133","article-title":"Modulation of glutaredoxin in the lung and sputum of cigarette smokers and chronic obstructive pulmonary disease","volume":"7","author":"Peltoniemi","year":"2006","journal-title":"Respir. Res."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0540","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1165\/rcmb.2010-0249OC","article-title":"Cigarette Smoke Targets Glutaredoxin 1, Increasing S-glutathionylation and Epithelial Cell Death","volume":"45","author":"Kuipers","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0545","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1378\/chest.125.4.1500","article-title":"Oral N-acetylcysteine attenuates elastase-induced pulmonary emphysema in rats","volume":"125","author":"Rubio","year":"2004","journal-title":"Chest"},{"key":"10.1016\/j.bbadis.2011.11.004_bb0550","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1183\/09031936.01.17303290","article-title":"The Bronchitis Randomized On NAC Cost-Utility Study (BRONCUS): hypothesis and design. BRONCUS-trial Committee","volume":"17","author":"Decramer","year":"2001","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0555","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1016\/S0140-6736(05)66456-2","article-title":"Effects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (Bronchitis Randomized on NAC Cost-Utility Study, BRONCUS): a randomised placebo-controlled trial","volume":"365","author":"Decramer","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.bbadis.2011.11.004_bb0560","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1136\/bmj.322.7297.1271","article-title":"Oral mucolytic drugs for exacerbations of chronic obstructive pulmonary disease: systematic review","volume":"322","author":"Poole","year":"2001","journal-title":"BMJ"},{"key":"10.1016\/j.bbadis.2011.11.004_bb0565","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF03256664","article-title":"Preventing exacerbations of chronic bronchitis and COPD: therapeutic potential of mucolytic agents","volume":"2","author":"Poole","year":"2003","journal-title":"Am. J. Respir. Med."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0570","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1034\/j.1399-3003.2000.16b12.x","article-title":"The effect of oral N-acetylcysteine in chronic bronchitis: a quantitative systematic review","volume":"16","author":"Stey","year":"2000","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0575","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0149-2918(00)88479-9","article-title":"Efficacy of oral long-term N-acetylcysteine in chronic bronchopulmonary disease: a meta-analysis of published double-blind, placebo-controlled clinical trials","volume":"22","author":"Grandjean","year":"2000","journal-title":"Clin. Ther."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0580","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1136\/thx.49.7.670","article-title":"Effect of N-acetyl cysteine on the concentrations of thiols in plasma, bronchoalveolar lavage fluid, and lung tissue","volume":"49","author":"Bridgeman","year":"1994","journal-title":"Thorax"},{"key":"10.1016\/j.bbadis.2011.11.004_bb0585","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1053\/rmed.2001.1066","article-title":"Long-term administration of N-acetylcysteine decreases hydrogen peroxide exhalation in subjects with chronic obstructive pulmonary disease","volume":"95","author":"Kasielski","year":"2001","journal-title":"Respir. Med."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0590","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1471-2466-4-13","article-title":"Randomised, controlled trial of N-acetylcysteine for treatment of acute exacerbations of chronic obstructive pulmonary disease [ISRCTN21676344]","volume":"4","author":"Black","year":"2004","journal-title":"BMC Pulm. Med."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0595","first-page":"135","article-title":"New developments in the treatment of COPD: comparing the effects of inhaled corticosteroids and N-acetylcysteine","volume":"56","author":"van Overveld","year":"2005","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0600","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.pupt.2004.09.030","article-title":"Long-term oral n-acetylcysteine reduces exhaled hydrogen peroxide in stable COPD","volume":"18","author":"De Benedetto","year":"2005","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0605","first-page":"143","article-title":"The effect of long-term treatment with erdosteine on chronic obstructive pulmonary disease: the EQUALIFE Study","volume":"30","author":"Moretti","year":"2004","journal-title":"Drugs Exp. Clin. Res."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0610","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1016\/S0140-6736(08)60869-7","article-title":"Effect of carbocisteine on acute exacerbation of chronic obstructive pulmonary disease (PEACE Study): a randomised placebo-controlled study","volume":"371","author":"Zheng","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.bbadis.2011.11.004_bb0615","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1183\/09031936.04.00016804","article-title":"Antioxidant properties of N-acetylcysteine: their relevance in relation to chronic obstructive pulmonary disease","volume":"23","author":"Dekhuijzen","year":"2004","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0620","first-page":"167","article-title":"Effects of oral administration of N-acetyl-L-cysteine: a multi-biomarker study in smokers","volume":"11","author":"Van Schooten","year":"2002","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0625","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1183\/09031936.04.00069004","article-title":"Does systemic inflammation trigger local exercise-induced oxidative stress in COPD?","volume":"23","author":"Koechlin","year":"2004","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0630","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0954-6111(06)80220-9","article-title":"N-acetylcysteine by metered dose inhaler in the treatment of chronic bronchitis: a multi-centre study","volume":"86","author":"Dueholm","year":"1992","journal-title":"Respir. Med."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0635","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1183\/09031936.03.00063402","article-title":"N-acetylcysteine reduces the risk of re-hospitalisation among patients with chronic obstructive pulmonary disease","volume":"21","author":"Gerrits","year":"2003","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0640","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.bcp.2011.05.014","article-title":"N-acetyl-l-cysteine (NAC) inhibit mucin synthesis and pro-inflammatory mediators in alveolar type II epithelial cells infected with influenza virus A and B and with respiratory syncytial virus (RSV)","volume":"82","author":"Mata","year":"2011","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0645","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0954-6111(97)90052-4","article-title":"Nacystelyn, a novel lysine salt of N-acetylcysteine, to augment cellular antioxidant defence in vitro","volume":"91","author":"Gillissen","year":"1997","journal-title":"Respir. Med."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0650","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/0954-6111(93)90074-A","article-title":"Lung deposition from four nebulizers","volume":"87","author":"Hardy","year":"1993","journal-title":"Respir. Med."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0655","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1111\/j.1530-0277.2000.tb04652.x","article-title":"Mitochondrial glutathione replacement restores surfactant synthesis and secretion in alveolar epithelial cells of ethanol-fed rats","volume":"24","author":"Guidot","year":"2000","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0660","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1165\/rcmb.2009-0459OC","article-title":"Cigarette smoke-induced changes to alveolar macrophage phenotype and function are improved by treatment with procysteine","volume":"44","author":"Hodge","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0665","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1016\/0006-2952(93)90432-V","article-title":"Elevation of cysteine and replenishment of glutathione in rat lung slices by cysteine isopropylester and other cysteine precursors","volume":"45","author":"Butterworth","year":"1993","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0670","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1034\/j.1399-3003.1999.13d22.x","article-title":"N-isobutyrylcysteine, a donor of systemic thiols, does not reduce the exacerbation rate in chronic bronchitis","volume":"13","author":"Ekberg-Jansson","year":"1999","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0675","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1586\/17476348.1.3.307","article-title":"Pharmacology and clinical efficacy of erdosteine in chronic obstructive pulmonary disease","volume":"1","author":"Moretti","year":"2007","journal-title":"Expert Rev. Respir. Med."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0680","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1517\/17425250902814790","article-title":"Erdosteine: its relevance in COPD treatment","volume":"5","author":"Moretti","year":"2009","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0685","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.pupt.2009.10.002","article-title":"The therapeutic efficacy of erdosteine in the treatment of chronic obstructive bronchitis: a meta-analysis of individual patient data","volume":"23","author":"Cazzola","year":"2010","journal-title":"Pulm. Pharmacol. Ther."},{"issue":"Suppl. 1","key":"10.1016\/j.bbadis.2011.11.004_bb0690","doi-asserted-by":"crossref","first-page":"S70","DOI":"10.1007\/s00408-007-9065-3","article-title":"Erdosteine: antitussive and anti-inflammatory effects","volume":"186","author":"Dal Negro","year":"2008","journal-title":"Lung"},{"key":"10.1016\/j.bbadis.2011.11.004_bb0695","doi-asserted-by":"crossref","first-page":"41","DOI":"10.5414\/CPP49041","article-title":"Erdosteine affects eicosanoid production in COPD","volume":"49","author":"Dal Negro","year":"2011","journal-title":"Int. J. Clin. Pharmacol. Ther."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0700","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1159\/000195871","article-title":"Long-lasting effects on rheology and clearance of bronchial mucus after short-term administration of high doses of carbocysteine-lysine to patients with chronic bronchitis","volume":"57","author":"Braga","year":"1990","journal-title":"Respiration"},{"key":"10.1016\/j.bbadis.2011.11.004_bb0705","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.ejphar.2004.10.007","article-title":"Exhaled Interleukine-6 and 8-isoprostane in chronic obstructive pulmonary disease: effect of carbocysteine lysine salt monohydrate","volume":"505","author":"Carpagnano","year":"2004","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0710","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1378\/chest.10-0920","article-title":"Carbocisteine protects against emphysema induced by cigarette smoke extract in rats","volume":"139","author":"Hanaoka","year":"2011","journal-title":"Chest"},{"key":"10.1016\/j.bbadis.2011.11.004_bb0715","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/1043-6618(95)80094-8","article-title":"Effectiveness of carbocysteine lysine salt monohydrate on models of airway inflammation and hyperresponsiveness","volume":"31","author":"Asti","year":"1995","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0720","first-page":"17","article-title":"Effects of carbocisteine on airway inflammation and related events in SO2-exposed rats","volume":"39","author":"Ishibashi","year":"2001","journal-title":"Nihon Kokyuki Gakkai Zasshi"},{"key":"10.1016\/j.bbadis.2011.11.004_bb0725","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1348-0421.1999.tb02381.x","article-title":"The effects of S-carboxymethylcysteine and N-acetylcysteine on the adherence of Moraxella catarrhalis to human pharyngeal epithelial cells","volume":"43","author":"Zheng","year":"1999","journal-title":"Microbiol. Immunol."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0730","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0882-4010(03)00048-2","article-title":"S-carboxymethylcysteine inhibits the attachment of Streptococcus pneumoniae to human pharyngeal epithelial cells","volume":"34","author":"Cakan","year":"2003","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0735","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1111\/j.1532-5415.2007.01373.x","article-title":"Carbocisteine improves quality of life in patients with chronic obstructive pulmonary disease","volume":"55","author":"Tatsumi","year":"2007","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0740","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1185\/03007997409112654","article-title":"An assessment of S-carboxymethylcysteine in the treatment of chronic bronchitis","volume":"2","author":"Aylward","year":"1974","journal-title":"Curr. Med. Res. Opin."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0745","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1378\/chest.70.4.506","article-title":"S-carboxymethylcysteine in the fluidification of sputum and treatment of chronic airway obstruction","volume":"70","author":"Edwards","year":"1976","journal-title":"Chest"},{"key":"10.1016\/j.bbadis.2011.11.004_bb0750","first-page":"1","article-title":"Double blind study of carbocysteine against placebo in chronic bronchitis; Mucoregulation in respiratory tract disorders","volume":"5","author":"Miskoviti","year":"1982","journal-title":"Proc. R. Soc. Med."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0755","first-page":"771","article-title":"Rheology of bronchial secretions and mucociliary transport (author's transl)","volume":"12","author":"Puchelle","year":"1976","journal-title":"Bull. Eur. Physiopathol. Respir."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0760","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1159\/000196540","article-title":"Prevention of acute exacerbations of chronic obstructive bronchitis with carbocysteine lysine salt monohydrate: a multicenter, double-blind, placebo-controlled trial","volume":"63","author":"Allegra","year":"1996","journal-title":"Respiration"},{"key":"10.1016\/j.bbadis.2011.11.004_bb0765","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/j.1742-1241.1985.tb07868.x","article-title":"Long-term oral carbocisteine therapy in patients with chronic bronchitis. A double blind trial with placebo control","volume":"39","author":"Grillage","year":"1985","journal-title":"Br. J. Clin. Pract."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0770","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/j.1532-5415.2005.00592_9.x","article-title":"Carbocisteine reduces frequency of common colds and exacerbations in patients with chronic obstructive pulmonary disease","volume":"54","author":"Yasuda","year":"2006","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0775","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1183\/09031936.06.00058505","article-title":"Carbocisteine inhibits rhinovirus infection in human tracheal epithelial cells","volume":"28","author":"Yasuda","year":"2006","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0780","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1183\/09031936.00018508","article-title":"Effect of fudosteine on mucin production","volume":"32","author":"Rhee","year":"2008","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0785","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.pupt.2004.11.002","article-title":"Inhibition of endotoxin- and antigen-induced airway inflammation by fudosteine, a mucoactive agent","volume":"18","author":"Komatsu","year":"2005","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0790","first-page":"109","article-title":"Phase III Clinical Study of SS320A. Double-blind Trial in Comparison with Placebo","volume":"18","author":"Nagaoka","year":"2002","journal-title":"J. Clin. Ther. Med."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0795","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1254\/fpj.116.371","article-title":"Effects of fudosteine, a new cysteine derivative, on airway secretion in rabbits and rats","volume":"116","author":"Takahashi","year":"2000","journal-title":"Nihon Yakurigaku Zasshi"},{"key":"10.1016\/j.bbadis.2011.11.004_bb0800","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1378\/chest.08-2105","article-title":"Peroxynitrite elevation in exhaled breath condensate of COPD and its inhibition by fudosteine","volume":"135","author":"Osoata","year":"2009","journal-title":"Chest"},{"key":"10.1016\/j.bbadis.2011.11.004_bb0805","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0304-3940(02)00427-5","article-title":"Ergothioneine treatment protects neurons against N-methyl-D-aspartate excitotoxicity in an in vivo rat retinal model","volume":"328","author":"Moncaster","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0810","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1006\/bbrc.1997.6109","article-title":"Antioxidant action of ergothioneine: assessment of its ability to scavenge peroxynitrite","volume":"231","author":"Aruoma","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0815","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/S0278-6915(99)00098-8","article-title":"Protection against oxidative damage and cell death by the natural antioxidant ergothioneine","volume":"37","author":"Aruoma","year":"1999","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0820","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1042\/0264-6021:3560799","article-title":"Role of ergothioneine on S-nitrosoglutathione catabolism","volume":"356","author":"Misiti","year":"2001","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0825","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/S0006-291X(03)00224-9","article-title":"Ergothioneine inhibits oxidative stress- and TNF-alpha-induced NF-kappa B activation and interleukin-8 release in alveolar epithelial cells","volume":"302","author":"Rahman","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0830","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1183\/09031936.00164407","article-title":"Effects of edaravone, a free-radical scavenger, on bleomycin-induced lung injury in mice","volume":"32","author":"Tajima","year":"2008","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0835","first-page":"899","article-title":"Beyond neurological disease: New targets for edaravone (Review)","volume":"28","author":"Kikuchi","year":"2011","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0840","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1089\/ars.2009.2814","article-title":"Edaravone inhibits protein carbonylation by a direct carbonyl-scavenging mechanism: focus on reactivity, selectivity, and reaction mechanisms","volume":"12","author":"Aldini","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0845","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1164\/rccm.201010-1605OC","article-title":"Oxidative Stress-induced Antibodies to Carbonyl-modified Protein Correlate with Severity of Chronic Obstructive Pulmonary Disease","volume":"184","author":"Kirkham","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0850","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1002\/med.20073","article-title":"Intervention strategies to inhibit protein carbonylation by lipoxidation-derived reactive carbonyls","volume":"27","author":"Aldini","year":"2007","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0855","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/S0022-3565(24)36676-5","article-title":"Effects of a novel free radical scavenger, MCl-186, on ischemic brain damage in the rat distal middle cerebral artery occlusion model","volume":"281","author":"Kawai","year":"1997","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0860","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1016\/S0022-3565(25)38652-0","article-title":"Protective effects of MCI-186 on cerebral ischemia: possible involvement of free radical scavenging and antioxidant actions","volume":"268","author":"Watanabe","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0865","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1016\/S0024-3205(00)00824-9","article-title":"MCI-186: further histochemical and biochemical evidence of neuroprotection","volume":"67","author":"Wu","year":"2000","journal-title":"Life Sci."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0870","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.freeradbiomed.2004.10.029","article-title":"Edaravone protects against lung injury induced by intestinal ischemia\/reperfusion in rat","volume":"38","author":"Ito","year":"2005","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0875","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.ejphar.2009.12.025","article-title":"Protective effects of the free radical scavenger edaravone on acute pancreatitis-associated lung injury","volume":"630","author":"Yang","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0880","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1440-1681.2007.04528.x","article-title":"The specific free radical scavenger edaravone suppresses bleomycin-induced acute pulmonary injury in rabbits","volume":"34","author":"Asai","year":"2007","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0885","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.intimp.2010.10.012","article-title":"Edaravone, a novel antidote against lung injury and pulmonary fibrosis induced by paraquat?","volume":"11","author":"Zhi","year":"2011","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0890","doi-asserted-by":"crossref","first-page":"3086","DOI":"10.1002\/art.30470","article-title":"The specific free radical scavenger edaravone suppresses fibrosis in the bleomycin-induced and tight skin mouse models of systemic sclerosis","volume":"63","author":"Yoshizaki","year":"2011","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0895","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.pupt.2008.06.006","article-title":"Biphasic effects of free radical scavengers against bleomycin-induced pulmonary fibrosis","volume":"21","author":"Fujita","year":"2008","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0900","doi-asserted-by":"crossref","first-page":"10438","DOI":"10.1016\/S0021-9258(18)60979-2","article-title":"Novel 21-amino steroids as potent inhibitors of iron-dependent lipid peroxidation","volume":"262","author":"Braughler","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0905","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1183\/09031936.96.09040758","article-title":"Lazaroid U-74389F attenuates phorbol ester-induced lung injury in rabbits","volume":"9","author":"Miniati","year":"1996","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0910","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/00003246-199501000-00022","article-title":"Effects of treatment with the 21-aminosteroid, U7438F, on pulmonary cytokine expression following hemorrhage and resuscitation","volume":"23","author":"Shenkar","year":"1995","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0915","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1159\/000196704","article-title":"A free radical scavenger (Lazaroid U75412E) attenuates tumor necrosis factor-alpha generation in a rabbit model of smoke-induced lung injury","volume":"64","author":"Wang","year":"1997","journal-title":"Respiration"},{"key":"10.1016\/j.bbadis.2011.11.004_bb0920","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1177\/074823379901500501","article-title":"Functional alterations of alveolar macrophages subjected to smoke exposure and antioxidant lazaroids","volume":"15","author":"Wang","year":"1999","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.bbadis.2011.11.004_bb0925","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1152\/jappl.1993.74.5.2155","article-title":"Attenuation of acute lung injury and oxygen radical production by the 21-aminosteroid, U-78518F","volume":"74","author":"Tanigaki","year":"1993","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0930","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1006\/pupt.1998.0114","article-title":"Protective effects of the lazaroid U-74389G against hyperoxia in rat type II pneumocytes","volume":"11","author":"van Klaveren","year":"1998","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0935","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1046\/j.1440-1843.1999.00169.x","article-title":"A 21-aminosteroid, U-74006F, attenuates endotoxin-induced lung injury in awake sheep","volume":"4","author":"Kubo","year":"1999","journal-title":"Respirology"},{"key":"10.1016\/j.bbadis.2011.11.004_bb0940","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1183\/09031936.96.09102044","article-title":"Effect of the 21-aminosteroid U-74006F on antigen-induced bronchoconstriction and bronchoalveolar eosinophilia in allergic sheep","volume":"9","author":"Fujimoto","year":"1996","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.bbadis.2011.11.004_bb0945","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1097\/00003246-199803000-00029","article-title":"Effects of the lazaroid, tirilazad mesylate, on sepsis-induced acute lung injury in minipigs","volume":"26","author":"Nakayama","year":"1998","journal-title":"Crit. Care Med."},{"issue":"Suppl. 10","key":"10.1016\/j.bbadis.2011.11.004_bb0950","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1289\/ehp.94102s10193","article-title":"Attenuation of oxidant-induced lung injury by 21-aminosteroids (lazaroids): correlation with the mRNA expression for E-selectin, P-selectin, ICAM-1, and VCAM-1","volume":"102","author":"Griffin","year":"1994","journal-title":"Environ. Health Perspect."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443911002547?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443911002547?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T23:23:24Z","timestamp":1741908204000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443911002547"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":190,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["S0925443911002547"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2011.11.004","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2012,5]]}}}