{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T05:29:31Z","timestamp":1768454971756,"version":"3.49.0"},"reference-count":86,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"NIH"},{"name":"Hibernia National Bank\/Edward G Schleider Chair"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1016\/j.bbadis.2013.01.002","type":"journal-article","created":{"date-parts":[[2013,1,9]],"date-time":"2013-01-09T21:27:06Z","timestamp":1357766826000},"page":"1456-1462","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Prolonged diet induced obesity has minimal effects towards brain pathology in mouse model of cerebral amyloid angiopathy: Implications for studying obesity\u2013brain interactions in mice"],"prefix":"10.1016","volume":"1832","author":[{"given":"Le","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalavathi","family":"Dasuri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun-Ok","family":"Fernandez-Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annadora J.","family":"Bruce-Keller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linnea R.","family":"Freeman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer K.","family":"Pepping","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina L.","family":"Beckett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Paul","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey N.","family":"Keller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2013.01.002_bb0005","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1016\/S0140-6736(12)60360-2","article-title":"Diabetes and cognitive dysfunction","volume":"379","author":"McCrimmon","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.bbadis.2013.01.002_bb0010","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1749-6632.2011.06274.x","article-title":"Obesity, leptin, and Alzheimer's disease","volume":"1243","author":"Lee","year":"2012","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0015","doi-asserted-by":"crossref","first-page":"e426","DOI":"10.1111\/j.1467-789X.2010.00825.x","article-title":"Body mass index in midlife and late-life as a risk factor for dementia: a meta-analysis of prospective studies","volume":"12","author":"Anstey","year":"2011","journal-title":"Obes. Rev."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0020","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1001\/archneurol.2009.27","article-title":"The role of metabolic disorders in Alzheimer disease and vascular dementia: two roads converged","volume":"66","author":"Craft","year":"2009","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0025","doi-asserted-by":"crossref","first-page":"117","DOI":"10.2174\/156720507780362065","article-title":"The epidemiology of adiposity and dementia","volume":"4","author":"Whitmer","year":"2007","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0030","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1111\/j.1476-5381.2011.01472.x","article-title":"Obesity and risk of vascular disease: importance of endothelium-dependent vasoconstriction","volume":"165","author":"Barton","year":"2012","journal-title":"Br. J. Pharmacol."},{"issue":"Suppl. 3","key":"10.1016\/j.bbadis.2013.01.002_bb0035","doi-asserted-by":"crossref","first-page":"S84","DOI":"10.1016\/S1262-3636(10)70472-9","article-title":"Stroke in diabetic patients","volume":"36","author":"B\u00e9jot","year":"2010","journal-title":"Diabetes Metab."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0040","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1212\/WNL.0b013e3181c0d4b6","article-title":"Adiposity indicators and dementia over 32years in Sweden","volume":"73","author":"Gustafson","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.bbadis.2013.01.002_bb0045","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1001\/archneurol.2008.582","article-title":"Midlife and late-life obesity and the risk of dementia: cardiovascular health study","volume":"66","author":"Fitzpatrick","year":"2009","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0050","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1212\/01.wnl.0000306313.89165.ef","article-title":"Central obesity and increased risk of dementia more than three decades later","volume":"71","author":"Whitmer","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.bbadis.2013.01.002_bb0055","doi-asserted-by":"crossref","first-page":"103","DOI":"10.2174\/156720507780362047","article-title":"Body mass index in midlife and risk of Alzheimer disease and vascular dementia","volume":"4","author":"Whitmer","year":"2007","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0060","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1097\/JGP.0b013e318050c98f","article-title":"Midlife risk factors for subtypes of dementia: a nested case-control study in Taiwan","volume":"15","author":"Chiang","year":"2007","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.bbadis.2013.01.002_bb0065","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1001\/archneur.62.10.1556","article-title":"Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease","volume":"62","author":"Kivipelto","year":"2005","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0070","doi-asserted-by":"crossref","first-page":"351982","DOI":"10.1155\/2011\/351982","article-title":"Rodent models for metabolic syndrome research","volume":"2011","author":"Panchal","year":"2011","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0075","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/0026-0495(76)90109-8","article-title":"The development of obesity, hyperinsulinemia, and hyperglycemia in ob\/ob mice","volume":"25","author":"Dubuc","year":"1976","journal-title":"Metabolism"},{"key":"10.1016\/j.bbadis.2013.01.002_bb0080","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1093\/cvr\/cvm001","article-title":"Dyslipidaemia in type II diabetic mice does not aggravate contractile impairment but increases ventricular stiffness","volume":"77","author":"Van den Bergh","year":"2008","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0085","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1194\/jlr.M003780","article-title":"Loss of stearoyl-CoA desaturase 1 rescues cardiac function in obese leptin-deficient mice","volume":"51","author":"Dobrzyn","year":"2010","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0090","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1053\/j.gastro.2008.02.055","article-title":"Obesity-induced lymphocyte hyperresponsiveness to chemokines: a new mechanism of fatty liver inflammation in obese mice","volume":"134","author":"Bigorgne","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbadis.2013.01.002_bb0095","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.lfs.2006.03.022","article-title":"Genistein and daidzein modulate hepatic glucose and lipid regulating enzyme activities in C57BL\/KsJ-db\/db mice","volume":"79","author":"Ae Park","year":"2006","journal-title":"Life Sci."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0100","first-page":"G855","article-title":"Insulinand leptin-regulated fatty acid uptake plays a key causal role in hepatic steatosis in mice with intact leptin signaling but not in ob\/ob or db\/db mice","volume":"299","author":"Ge","year":"2010","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0105","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1038\/ijo.2010.47","article-title":"Increased adipogenic conversion of muscle satellite cells in obese Zucker rats","volume":"34","author":"Scarda","year":"2010","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0110","doi-asserted-by":"crossref","DOI":"10.1186\/1475-2840-8-39","article-title":"Altered myocardial substrate metabolism is associated with myocardial dysfunction in early diabetic cardiomyopathy in rats: studies using positron emission tomography","volume":"8","author":"Van den Brom","year":"2009","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0115","doi-asserted-by":"crossref","first-page":"H153","DOI":"10.1152\/ajpheart.01142.2008","article-title":"Superoxide production by NAD(P)H oxidase and mitochondria is increased in genetically obese and hyperglycemic rat heart and aorta before the development of cardiac dysfunction. The role of glucose-6-phosphate dehydrogenase-derived NADPH","volume":"297","author":"Serpillon","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0120","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1002\/ana.1009","article-title":"Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy","volume":"49","author":"Grabowski","year":"2001","journal-title":"Ann. Neurol."},{"issue":"Suppl. 1","key":"10.1016\/j.bbadis.2013.01.002_bb0125","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1601-183X.2007.00380.x","article-title":"Cerebral amyloid angiopathy: pathogenetic mechanisms and link to dense amyloid plaques","volume":"7","author":"Kumar-Singh","year":"2008","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0435","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1136\/jnnp.65.3.405","article-title":"A quartet of Down's syndrome, Alzheimer's disease, cerebral amyloid angiopathy, and cerebral haemorrhage: interacting genetic risk factors","volume":"65","author":"McCarron","year":"1998","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.bbadis.2013.01.002_bb0130","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/978-3-7091-0693-8_3","article-title":"Cerebral amyloid angiopathy-related microhemorrhages in Alzheimer's disease: a review of investigative animal models","volume":"111","author":"Chen","year":"2011","journal-title":"Acta Neurochir. Suppl."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0135","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.2174\/092986709788682047","article-title":"Cerebral amyloid angiopathy: a common cause of cerebral hemorrhage","volume":"16","author":"Pezzini","year":"2009","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0140","doi-asserted-by":"crossref","first-page":"20296","DOI":"10.1074\/jbc.M312946200","article-title":"Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch\/Iowa mutant form of amyloid beta-protein precursor","volume":"279","author":"Davis","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0145","doi-asserted-by":"crossref","first-page":"S135","DOI":"10.1161\/STROKEAHA.110.595272","article-title":"Enhanced capillary amyloid angiopathy-associated pathology in Tg-SwDI mice with deleted nitric oxide synthase 2","volume":"41","author":"Van Nostrand","year":"2010","journal-title":"Stroke"},{"key":"10.1016\/j.bbadis.2013.01.002_bb0150","doi-asserted-by":"crossref","first-page":"483","DOI":"10.2353\/ajpath.2008.071191","article-title":"Tg-SwDI transgenic mice exhibit novel alterations in AbetaPP processing, Abeta degradation, and resilient amyloid angiopathy","volume":"173","author":"Van Vickle","year":"2008","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0155","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1017\/S0954422410000168","article-title":"High-fat diet-induced obesity in animal models","volume":"23","author":"Hariri","year":"2010","journal-title":"Nutr. Res. Rev."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0160","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3233\/JAD-2008-15103","article-title":"Limited Alzheimer-type neurodegeneration in experimental obesity and type 2 diabetes mellitus","volume":"15","author":"Moroz","year":"2008","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0165","first-page":"36275","article-title":"Intake of sucrose-sweetened water induces insulin resistance and exacerbates memory deficits and amyloidosis in a transgenic mouse model of Alzheimer disease","volume":"282","author":"Cao","year":"2007","journal-title":"J. Biol. Dis."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0170","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1111\/j.1582-4934.2011.01384.x","article-title":"Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP\/PS1 transgenic mice","volume":"16","author":"Hiltunen","year":"2012","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0175","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1159\/000335568","article-title":"Review of cerebral microangiopathy and Alzheimer's disease: relation between white matter hyperintensities and microbleeds","volume":"32","author":"Hommet","year":"2011","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0185","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S1357-4310(00)01762-7","article-title":"Cellular and transgenic animal models of cerebrovascular amyloidosis","volume":"6","author":"Van Nostrand","year":"2000","journal-title":"Mol. Med. Today"},{"key":"10.1016\/j.bbadis.2013.01.002_bb0190","doi-asserted-by":"crossref","first-page":"E599","DOI":"10.1152\/ajpendo.00059.2011","article-title":"Aging is associated with hypoxia and oxidative stress in adipose tissue: implications for adipose function","volume":"301","author":"Zhang","year":"2011","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0195","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3233\/JAD-2012-120655","article-title":"Postmortem Pittsburgh Compound B (PiB) Binding Increases with Alzheimer's Disease Progression","volume":"32","author":"Beckett","year":"2012","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0200","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/ana.23633","article-title":"Pittsburgh compound B and the postmortem diagnosis of Alzheimers disease","volume":"72","author":"Niedowicz","year":"2012","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0205","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.nbd.2011.07.012","article-title":"Cognitive impairment in humanized APP\u00d7PS1 mice is linked to A\u03b2(1\u201342) and NOX activation","volume":"44","author":"Bruce-Keller","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0210","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.nbd.2007.06.002","article-title":"H. 3rd LeVine, J.N. Keller, Abeta solubility and deposition during AD progression and in APPxPS-1 knock-in mice","volume":"27","author":"Murphy","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0215","doi-asserted-by":"crossref","first-page":"e43193","DOI":"10.1371\/journal.pone.0043193","article-title":"Mutant Amyloid Precursor Protein Differentially Alters Adipose Biology under Obesogenic and Non-Obesogenic Conditions","volume":"7","author":"Freeman","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2013.01.002_bb0220","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.lfs.2011.12.022","article-title":"Hypercholesterolemia accelerates intraneuronal accumulation of A\u03b2 oligomers resulting in memory impairment in Alzheimer's disease model mice","volume":"91","author":"Umeda","year":"2012","journal-title":"Life Sci."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0225","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/j.1471-4159.2008.05415.x","article-title":"High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice","volume":"106","author":"Thirumangalakudi","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0230","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1006\/nbdi.2000.0304","article-title":"Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model","volume":"7","author":"Refolo","year":"2000","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0235","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/j.1463-1326.2011.01536.x","article-title":"Obesity and type 2 diabetes: which patients are at risk?","volume":"14","author":"Garber","year":"2012","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0240","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1001\/jama.2009.2014","article-title":"Prevalence and trends in obesity among US adults, 1999\u20132008","volume":"303","author":"Flegal","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.bbadis.2013.01.002_bb0245","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1111\/j.1742-1241.2007.01336.x","article-title":"The relationship of body mass index to diabetes mellitus, hypertension and dyslipidaemia: comparison of data from two national surveys","volume":"61","author":"Bays","year":"2007","journal-title":"Int. J. Clin. Pract."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0250","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.jvs.2011.01.003","article-title":"Vascular biology of metabolic syndrome","volume":"54","author":"Vykoukal","year":"2011","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0255","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1258\/vasc.2011.201201","article-title":"Biology of metabolic syndrome in a vascular patient","volume":"20","author":"Vykoukal","year":"2012","journal-title":"Vascular"},{"key":"10.1016\/j.bbadis.2013.01.002_bb0260","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/j.1753-4887.2011.00390.x","article-title":"Effects of dietary macronutrient distribution on vascular integrity in obesity and metabolic syndrome","volume":"69","author":"Gregory","year":"2011","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0265","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1111\/j.1365-2826.2012.02327.x","article-title":"Impairment of fear-conditioning responses and changes of brain neurotrophic factors in diet-induced obese mice","volume":"24","author":"Yamada-Goto","year":"2012","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0270","doi-asserted-by":"crossref","first-page":"23024","DOI":"10.1074\/jbc.M112.367011","article-title":"Exercise is more effective than diet control in preventing high fat diet-induced \u03b2-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice","volume":"287","author":"Maesako","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0275","doi-asserted-by":"crossref","first-page":"e30378","DOI":"10.1371\/journal.pone.0030378","article-title":"Amyloid precursor protein and proinflammatory changes are regulated in brain and adipose tissue in a murine model of high fat diet-induced obesity","volume":"7","author":"Puig","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2013.01.002_bb0280","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1007\/s00125-011-2160-2","volume":"54","author":"Mody","year":"2011","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbadis.2013.01.002_bb0285","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1002\/cne.23233","article-title":"Regional astrogliosis in the mouse hypothalamus in response to obesity","volume":"521","author":"Buckman","year":"2013","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0290","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.nlm.2012.04.005","article-title":"Adult mice maintained on a high-fat diet exhibit object location memory deficits and reduced hippocampal SIRT1 gene expression","volume":"98","author":"Heyward","year":"2012","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0295","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/ijo.2012.48","article-title":"Diet-induced obesity promotes depressive-like behaviour that is associated with neural adaptations in brain reward circuitry","volume":"37","author":"Sharma","year":"2013","journal-title":"Int. J. Obes. (Lond)"},{"key":"10.1016\/j.bbadis.2013.01.002_bb0300","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.neuroscience.2011.06.072","article-title":"High-fat diet selectively protects against the effects of chronic social stress in the mouse","volume":"192","author":"Finger","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbadis.2013.01.002_bb0305","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.cmet.2010.03.009","article-title":"Brown fat and the myth of diet-induced thermogenesis","volume":"11","author":"Kozak","year":"2010","journal-title":"Cell Metab."},{"issue":"Suppl. 1","key":"10.1016\/j.bbadis.2013.01.002_bb0310","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1038\/ijo.2010.179","article-title":"Brown fat thermogenesis and body weight regulation in mice: relevance to humans","volume":"34","author":"Kozak","year":"2010","journal-title":"Int. J. Obes. (Lond)"},{"key":"10.1016\/j.bbadis.2013.01.002_bb0315","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1073\/pnas.1017884108","article-title":"Both liver-X receptor (LXR) isoforms control energy expenditure by regulating brown adipose tissue activity","volume":"108","author":"Korach-Andr\u00e9","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0320","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1038\/oby.2008.267","article-title":"Amyloid precursor protein expression is upregulated in adipocytes in obesity","volume":"16","author":"Lee","year":"2008","journal-title":"Obesity"},{"key":"10.1016\/j.bbadis.2013.01.002_bb0325","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.04-3182fje","article-title":"Caloric restriction attenuates beta-amyloid neuropathology in a mouse model of Alzheimer's disease","volume":"19","author":"Wang","year":"2005","journal-title":"FASEB J."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0330","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.bbi.2011.02.008","article-title":"Brain inflammation is induced by co-morbidities and risk factors for stroke","volume":"25","author":"Drake","year":"2011","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0335","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1111\/j.1471-4159.2008.05798.x","article-title":"Effects of short-term Western diet on cerebral oxidative stress and diabetes related factors in APP x PS1 knock-in mice","volume":"108","author":"Studzinski","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0340","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1111\/j.1471-4159.2012.07660.x","article-title":"Saturated long-chain fatty acids activate inflammatory signaling in astrocytes","volume":"120","author":"Gupta","year":"2012","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0345","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.freeradbiomed.2010.03.006","article-title":"NOX activity in brain aging: exacerbation by high fat diet","volume":"49","author":"Bruce-Keller","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0350","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jneuroim.2009.11.010","article-title":"Cognitive impairment following high fat diet consumption is associated with brain inflammation","volume":"219","author":"Pistell","year":"2010","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0355","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1179\/1743132812Y.0000000019","article-title":"Injury and repair in the neurovascular unit","volume":"34","author":"Xing","year":"2012","journal-title":"Neurol. Res."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0360","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1177\/0192623310385830","article-title":"Glia-induced reversible disruption of blood\u2013brain barrier integrity and neuropathological response of the neurovascular unit","volume":"39","author":"Willis","year":"2011","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0365","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1748-1716.2011.02256.x","article-title":"The neurovascular unit in brain function and disease","volume":"203","author":"Lecrux","year":"2011","journal-title":"Acta Physiol (Oxf.)"},{"key":"10.1016\/j.bbadis.2013.01.002_bb0370","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.tins.2005.02.001","article-title":"Neurovascular mechanisms of Alzheimer's neurodegeneration","volume":"28","author":"Zlokovic","year":"2005","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0375","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nrn3114","article-title":"Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders","volume":"12","author":"Zlokovic","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0380","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000319991","article-title":"Contribution of adipose tissue to health span and longevity","volume":"37","author":"Huffman","year":"2010","journal-title":"Interdiscip. Top. Gerontol."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0385","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/j.1474-9726.2008.00391.x","article-title":"Visceral adipose tissue modulates mammalian longevity","volume":"7","author":"Muzumdar","year":"2008","journal-title":"Aging Cell"},{"key":"10.1016\/j.bbadis.2013.01.002_bb0390","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.exger.2007.03.003","article-title":"Aging in adipocytes: potential impact of inherent, depot-specific mechanisms","volume":"42","author":"Cartwright","year":"2007","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0395","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.yasu.2012.05.002","article-title":"Morbidity and effectiveness of laparoscopic sleeve gastrectomy, adjustable gastric band, and gastric bypass for morbid obesity","volume":"46","author":"Jackson","year":"2012","journal-title":"Adv. Surg."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0400","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/nmo.12034","article-title":"Roux-en-Y gastric bypass surgery increases number but not density of CCK-, GLP-1-, 5-HT-, and neurotensin-expressing enteroendocrine cells in rats","volume":"25","author":"Mumphrey","year":"2013","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0405","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/ijo.2010.174","article-title":"Roux-en-Y gastric bypass surgery changes food reward in rats","volume":"35","author":"Shin","year":"2011","journal-title":"Int. J. Obes. (Lond)"},{"key":"10.1016\/j.bbadis.2013.01.002_bb0410","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1210\/en.2009-1332","article-title":"Meal-induced hormone responses in a rat model of Roux-en-Y gastric bypass surgery","volume":"151","author":"Shin","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbadis.2013.01.002_bb0415","doi-asserted-by":"crossref","first-page":"731","DOI":"10.3233\/JAD-2009-1021","article-title":"Leptin: a novel therapeutic strategy for Alzheimer's disease","volume":"16","author":"Tezapsidis","year":"2009","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0420","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.bbadis.2008.12.004","article-title":"Leptin signaling in brain: A link between nutrition and cognition?","volume":"1792","author":"Morrison","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2013.01.002_bb0425","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1749-6632.2012.06472.x","article-title":"Leptin action on nonneuronal cells in the CNS: potential clinical applications","volume":"1264","author":"Pan","year":"2012","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bbadis.2013.01.002_bb0430","doi-asserted-by":"crossref","first-page":"7036","DOI":"10.1073\/pnas.1000645107","article-title":"Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Abeta deposition in an Alzheimer mouse model with diabetes","volume":"107","author":"Takeda","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443913000057?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443913000057?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T14:42:50Z","timestamp":1714833770000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443913000057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":86,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["S0925443913000057"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2013.01.002","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2013,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prolonged diet induced obesity has minimal effects towards brain pathology in mouse model of cerebral amyloid angiopathy: Implications for studying obesity\u2013brain interactions in mice","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2013.01.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}