{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T21:09:30Z","timestamp":1793912970617,"version":"4.8.0"},"reference-count":171,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,6,17]],"date-time":"2015-06-17T00:00:00Z","timestamp":1434499200000},"content-version":"vor","delay-in-days":473,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["DK80380R01"],"award-info":[{"award-number":["DK80380R01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["DK036836"],"award-info":[{"award-number":["DK036836"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["DK046200"],"award-info":[{"award-number":["DK046200"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000041","name":"American Diabetes Association","doi-asserted-by":"crossref","award":["110BS97"],"award-info":[{"award-number":["110BS97"]}],"id":[{"id":"10.13039\/100000041","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1016\/j.bbadis.2013.05.017","type":"journal-article","created":{"date-parts":[[2013,5,22]],"date-time":"2013-05-22T11:30:20Z","timestamp":1369222220000},"page":"446-462","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":573,"title":["Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance"],"prefix":"10.1016","volume":"1842","author":[{"given":"Byung-Cheol","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jongsoon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2013.05.017_bb0005","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1038\/nature05482","article-title":"Mechanisms linking obesity to insulin resistance and type 2 diabetes","volume":"444","author":"Kahn","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0010","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev.physiol.68.040104.124723","article-title":"From mice to men: insights into the insulin resistance syndromes","volume":"68","author":"Biddinger","year":"2006","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0015","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1126\/science.1092952","article-title":"Insulin signaling in health and disease","volume":"302","author":"White","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0020","first-page":"436","article-title":"Insulin receptor family","volume":"vol. 2","author":"Pilch","year":"2004"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0025","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/nm.2627","article-title":"The cellular and signaling networks linking the immune system and metabolism in disease","volume":"18","author":"Osborn","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0030","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1056\/NEJM200103223441207","article-title":"Cytokine pathways and joint inflammation in rheumatoid arthritis","volume":"344","author":"Choy","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0035","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1056\/NEJMra043430","article-title":"Inflammation, atherosclerosis, and coronary artery disease","volume":"352","author":"Hansson","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0040","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1056\/NEJMp038190","article-title":"From asthma to atherosclerosis\u20135-lipoxygenase, leukotrienes, and inflammation","volume":"350","author":"De Caterina","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0045","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/s12272-013-0023-8","article-title":"Adipose tissue macrophages in the development of obesity-induced inflammation, insulin resistance and Type 2 Diabetes","volume":"36","author":"Lee","year":"2013","journal-title":"Arch. Pharmacal Res."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0050","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nature10146","article-title":"Progress and challenges in translating the biology of atherosclerosis","volume":"473","author":"Libby","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0055","doi-asserted-by":"crossref","first-page":"13580","DOI":"10.1016\/S0021-9258(18)42251-X","article-title":"Transcriptional repression of the C\/EBP-alpha and GLUT4 genes in 3 T3-L1 adipocytes by tumor necrosis factor-alpha. Regulations is coordinate and independent of protein synthesis","volume":"267","author":"Stephens","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0060","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1074\/jbc.272.2.971","article-title":"Tumor necrosis factor-alpha-induced insulin resistance in 3 T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT4 expression without a loss of insulin receptor-mediated signal transduction","volume":"272","author":"Stephens","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0065","doi-asserted-by":"crossref","first-page":"4928","DOI":"10.1210\/endo.139.12.6336","article-title":"An in vivo model for elucidation of the mechanism of tumor necrosis factor-alpha (TNF-alpha)-induced insulin resistance: evidence for differential regulation of insulin signaling by TNF-alpha","volume":"139","author":"Cheung","year":"1998","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0070","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1126\/science.7678183","article-title":"Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance","volume":"259","author":"Hotamisligil","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0075","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/39335","article-title":"Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function","volume":"389","author":"Uysal","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0080","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.2337\/diab.46.9.1526","article-title":"Targeted disruption of the tumor necrosis factor-alpha gene: metabolic consequences in obese and nonobese mice","volume":"46","author":"Ventre","year":"1997","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0085","doi-asserted-by":"crossref","first-page":"E713","DOI":"10.1152\/ajpendo.00194.2007","article-title":"Macrophage TNF-alpha contributes to insulin resistance and hepatic steatosis in diet-induced obesity","volume":"293","author":"De Taeye","year":"2007","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0090","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1161\/01.CIR.102.1.42","article-title":"Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS)","volume":"102","author":"Festa","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0095","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0021-9150(99)00463-3","article-title":"Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link?","volume":"148","author":"Yudkin","year":"2000","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0100","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.2337\/diabetes.50.10.2384","article-title":"The relation of markers of inflammation to the development of glucose disorders in the elderly: the Cardiovascular Health Study","volume":"50","author":"Barzilay","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0105","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1093\/aje\/155.1.57","article-title":"Leukocyte count, erythrocyte sedimentation rate, and diabetes incidence in a national sample of US adults","volume":"155","author":"Ford","year":"2002","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0110","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.2337\/diabetes.51.5.1596","article-title":"C-reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention Study","volume":"51","author":"Freeman","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0115","doi-asserted-by":"crossref","first-page":"813","DOI":"10.2337\/diacare.27.3.813","article-title":"Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes","volume":"27","author":"Pickup","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0120","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1161\/01.ATV.0000065636.15310.9C","article-title":"C-reactive protein is independently associated with fasting insulin in nondiabetic women","volume":"23","author":"Pradhan","year":"2003","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0125","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1001\/jama.286.3.327","article-title":"C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus","volume":"286","author":"Pradhan","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0130","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1016\/S0140-6736(99)01046-6","article-title":"Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study","volume":"353","author":"Schmidt","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0135","doi-asserted-by":"crossref","first-page":"455","DOI":"10.2337\/diabetes.51.2.455","article-title":"High white blood cell count is associated with a worsening of insulin sensitivity and predicts the development of type 2 diabetes","volume":"51","author":"Vozarova","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0140","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2165\/00024677-200302020-00002","article-title":"Inflammation and its association with glucose disorders and cardiovascular disease","volume":"2","author":"Barzilay","year":"2003","journal-title":"Treat. Endocrinol."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0145","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.2337\/diabetes.52.7.1799","article-title":"Low-grade systemic inflammation and the development of type 2 diabetes: the atherosclerosis risk in communities study","volume":"52","author":"Duncan","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0150","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1172\/JCI11559","article-title":"Prevention of fat-induced insulin resistance by salicylate","volume":"108","author":"Kim","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0155","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1126\/science.1061620","article-title":"Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta","volume":"293","author":"Yuan","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0160","doi-asserted-by":"crossref","first-page":"289","DOI":"10.2337\/dc07-1338","article-title":"Salsalate improves glycemia and inflammatory parameters in obese young adults","volume":"31","author":"Fleischman","year":"2008","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0165","doi-asserted-by":"crossref","first-page":"346","DOI":"10.7326\/0003-4819-152-6-201003160-00004","article-title":"The effects of salsalate on glycemic control in patients with type 2 diabetes: a randomized trial","volume":"152","author":"Goldfine","year":"2010","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0170","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/j.1752-8062.2008.00026.x","article-title":"Use of salsalate to target inflammation in the treatment of insulin resistance and type 2 diabetes","volume":"1","author":"Goldfine","year":"2008","journal-title":"Clin. Transl. Sci."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0175","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1172\/JCI0214955","article-title":"Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes","volume":"109","author":"Hundal","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0180","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1172\/JCI57132","article-title":"Inflammatory links between obesity and metabolic disease","volume":"121","author":"Lumeng","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0185","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1146\/annurev-immunol-031210-101322","article-title":"Inflammatory mechanisms in obesity","volume":"29","author":"Gregor","year":"2011","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0190","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1172\/JCI200319451","article-title":"Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance","volume":"112","author":"Xu","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0195","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1172\/JCI200319246","article-title":"Obesity is associated with macrophage accumulation in adipose tissue","volume":"112","author":"Weisberg","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0200","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1111\/j.1365-2796.2007.01852.x","article-title":"Obesity-induced inflammation: a metabolic dialogue in the language of inflammation","volume":"262","author":"Ferrante","year":"2007","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0205","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1096\/fj.09-151340","article-title":"JNK1 and IKKbeta: molecular links between obesity and metabolic dysfunction","volume":"24","author":"Solinas","year":"2010","journal-title":"FASEB J."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0210","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1126\/science.1230721","article-title":"Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis","volume":"339","author":"Odegaard","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0215","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1146\/annurev-biochem-061009-102430","article-title":"Lipid droplets and cellular lipid metabolism","volume":"81","author":"Walther","year":"2012","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0220","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1073\/pnas.0905310107","article-title":"Inflammation and adipose tissue macrophages in lipodystrophic mice","volume":"107","author":"Herrero","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0225","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nri2921","article-title":"Adipokines in inflammation and metabolic disease","volume":"11","author":"Ouchi","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0230","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1146\/annurev.immunol.21.120601.141007","article-title":"Biology of hematopoietic stem cells and progenitors: implications for clinical application","volume":"21","author":"Kondo","year":"2003","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0235","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1038\/nri1733","article-title":"Monocyte and macrophage heterogeneity","volume":"5","author":"Gordon","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0240","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1038\/nrc2444","article-title":"The role of myeloid cells in the promotion of tumour angiogenesis","volume":"8","author":"Murdoch","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0245","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.cmet.2012.04.001","article-title":"Inflammation and lipid signaling in the etiology of insulin resistance","volume":"15","author":"Glass","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0250","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1172\/JCI26498","article-title":"MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity","volume":"116","author":"Kanda","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0255","doi-asserted-by":"crossref","first-page":"26602","DOI":"10.1074\/jbc.M601284200","article-title":"Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance","volume":"281","author":"Kamei","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0260","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1172\/JCI29881","article-title":"Obesity induces a phenotypic switch in adipose tissue macrophage polarization","volume":"117","author":"Lumeng","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0265","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/j.0105-2896.2009.00876.x","article-title":"Differentiation and function of mouse monocyte-derived dendritic cells in steady state and inflammation","volume":"234","author":"Dominguez","year":"2010","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0270","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1038\/ni.2419","article-title":"Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages","volume":"13","author":"Gautier","year":"2012","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0275","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.immuni.2011.09.007","article-title":"Dendritic cell and macrophage heterogeneity in vivo","volume":"35","author":"Hashimoto","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0280","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.2337\/db09-1402","article-title":"Dynamic, M2-like remodeling phenotypes of CD11c+ adipose tissue macrophages during high-fat diet-induced obesity in mice","volume":"59","author":"Shaul","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0285","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nri978","article-title":"Alternative activation of macrophages","volume":"3","author":"Gordon","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0290","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1161\/CIRCULATIONAHA.107.724096","article-title":"Remodeling phenotype of human subcutaneous adipose tissue macrophages","volume":"117","author":"Bourlier","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0295","doi-asserted-by":"crossref","first-page":"21904","DOI":"10.1074\/jbc.M111.315200","article-title":"Human adipose tissue macrophages display activation of cancer-related pathways","volume":"287","author":"Mayi","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0300","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1194\/jlr.M500294-JLR200","article-title":"Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans","volume":"46","author":"Cinti","year":"2005","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0305","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.immuni.2008.08.001","article-title":"Dendritic cells in vivo: a key target for a new vaccine science","volume":"29","author":"Steinman","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0310","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.cmet.2008.08.015","article-title":"Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals","volume":"8","author":"Patsouris","year":"2008","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0315","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.2337\/db11-1523","article-title":"Dendritic cells promote macrophage infiltration and comprise a substantial proportion of obesity-associated increases in CD11c+ cells in adipose tissue and liver","volume":"61","author":"Stefanovic-Racic","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0320","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.2337\/db11-1274","article-title":"Identification of adipose tissue dendritic cells correlated with obesity-associated insulin-resistance and inducing Th17 responses in mice and patients","volume":"61","author":"Bertola","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0325","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1084\/jem.20080414","article-title":"Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans","volume":"205","author":"Jaensson","year":"2008","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0330","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/nm.2353","article-title":"B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies","volume":"17","author":"Winer","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0335","doi-asserted-by":"crossref","first-page":"5133","DOI":"10.1073\/pnas.1215840110","article-title":"B cells promote inflammation in obesity and type 2 diabetes through regulation of T cell function and an inflammatory cytokine profile","volume":"110","author":"DeFuria","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0340","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nri3024","article-title":"Neutrophils in the activation and regulation of innate and adaptive immunity","volume":"11","author":"Mantovani","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0345","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1146\/annurev-immunol-020711-074942","article-title":"Neutrophil function: from mechanisms to disease","volume":"30","author":"Amulic","year":"2012","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0350","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/nri1785","article-title":"Neutrophils and immunity: challenges and opportunities","volume":"6","author":"Nathan","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0355","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1194\/jlr.M800132-JLR200","article-title":"Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding","volume":"49","author":"Elgazar-Carmon","year":"2008","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0360","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1038\/nm.2885","article-title":"Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase","volume":"18","author":"Talukdar","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0365","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/icb.2009.115","article-title":"Eosinophils and Th2 immunity: contemporary insights","volume":"88","author":"Spencer","year":"2010","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0370","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1146\/annurev.immunol.24.021605.090720","article-title":"The eosinophil","volume":"24","author":"Rothenberg","year":"2006","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0375","doi-asserted-by":"crossref","first-page":"22617","DOI":"10.1073\/pnas.1009152108","article-title":"IL-4\/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity","volume":"107","author":"Ricardo-Gonzalez","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0380","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1126\/science.1201475","article-title":"Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis","volume":"332","author":"Wu","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0385","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/nri2782","article-title":"Mast cell-orchestrated immunity to pathogens","volume":"10","author":"Abraham","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0390","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1146\/annurev.immunol.21.120601.141025","article-title":"Mast cells as \u201ctunable\u201d effector and immunoregulatory cells: recent advances","volume":"23","author":"Galli","year":"2005","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0395","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1038\/nm.1994","article-title":"Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice","volume":"15","author":"Liu","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0400","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1146\/annurev-cellbio-092910-154008","article-title":"Mechanisms of T cell development and transformation","volume":"27","author":"Koch","year":"2011","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0405","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/nri3321","article-title":"Master regulators or lineage-specifying? Changing views on CD4+ T cell transcription factors","volume":"12","author":"Oestreich","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0410","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.immuni.2011.07.010","article-title":"CD8(+) T cells: foot soldiers of the immune system","volume":"35","author":"Zhang","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0415","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/nm.2001","article-title":"Normalization of obesity-associated insulin resistance through immunotherapy","volume":"15","author":"Winer","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0420","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1161\/CIRCRESAHA.108.177105","article-title":"Interferon-gamma, a Th1 cytokine, regulates fat inflammation: a role for adaptive immunity in obesity","volume":"103","author":"Rocha","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0425","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.4049\/jimmunol.1000021","article-title":"Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: implications for systemic inflammation and insulin resistance","volume":"185","author":"Yang","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0430","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/nm.1964","article-title":"CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity","volume":"15","author":"Nishimura","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0435","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1038\/nm.2002","article-title":"Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters","volume":"15","author":"Feuerer","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0440","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1146\/annurev.immunol.25.022106.141623","article-title":"Regulatory T cells: mechanisms of differentiation and function","volume":"30","author":"Josefowicz","year":"2012","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0445","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/nature11132","article-title":"PPAR-gamma is a major driver of the accumulation and phenotype of adipose tissue Treg cells","volume":"486","author":"Cipolletta","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0450","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/nri1631","article-title":"Recognition of lipid antigens by T cells","volume":"5","author":"De Libero","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0455","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.immuni.2012.06.016","article-title":"Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production","volume":"37","author":"Lynch","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0460","doi-asserted-by":"crossref","first-page":"E1143","DOI":"10.1073\/pnas.1200498109","article-title":"Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice","volume":"109","author":"Wu","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0465","doi-asserted-by":"crossref","first-page":"e25478","DOI":"10.1371\/journal.pone.0025478","article-title":"Impact of CD1d deficiency on metabolism","volume":"6","author":"Kotas","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0470","doi-asserted-by":"crossref","first-page":"e19831","DOI":"10.1371\/journal.pone.0019831","article-title":"Mice lacking NKT cells but with a complete complement of CD8+ T-cells are not protected against the metabolic abnormalities of diet-induced obesity","volume":"6","author":"Mantell","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0475","doi-asserted-by":"crossref","first-page":"24378","DOI":"10.1074\/jbc.M112.371807","article-title":"Short term high fat diet challenge promotes alternative macrophage polarization in adipose tissue via natural killer T cells and interleukin-4","volume":"287","author":"Ji","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0480","doi-asserted-by":"crossref","first-page":"13561","DOI":"10.1074\/jbc.M112.350066","article-title":"Activation of natural killer T cells promotes M2 Macrophage polarization in adipose tissue and improves systemic glucose tolerance via interleukin-4 (IL-4)\/STAT6 protein signaling axis in obesity","volume":"287","author":"Ji","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0485","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1161\/ATVBAHA.109.198614","article-title":"Natural killer T cells are involved in adipose tissues inflammation and glucose intolerance in diet-induced obese mice","volume":"30","author":"Ohmura","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0490","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.1172\/JCI62739","article-title":"Natural killer T cells in adipose tissue prevent insulin resistance","volume":"122","author":"Schipper","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0495","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1128\/MCB.00552-12","article-title":"A novel function of adipocytes in lipid antigen presentation to iNKT cells","volume":"33","author":"Huh","year":"2013","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0500","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.0818-9641.2004.01252.x","article-title":"Natural killer T cells as targets for immunotherapy of autoimmune diseases","volume":"82","author":"Van Kaer","year":"2004","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0505","doi-asserted-by":"crossref","first-page":"4647","DOI":"10.4049\/jimmunol.163.9.4647","article-title":"Cutting edge: cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells","volume":"163","author":"Carnaud","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0510","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.4049\/jimmunol.163.5.2373","article-title":"Cutting edge: activation of NK T cells by CD1d and alpha-galactosylceramide directs conventional T cells to the acquisition of a Th2 phenotype","volume":"163","author":"Singh","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0515","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1084\/jem.192.5.741","article-title":"Tracking the response of natural killer T cells to a glycolipid antigen using CD1d tetramers","volume":"192","author":"Matsuda","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0520","doi-asserted-by":"crossref","first-page":"4305","DOI":"10.4049\/jimmunol.165.8.4305","article-title":"Selective bystander proliferation of memory CD4+ and CD8+ T cells upon NK T or T cell activation","volume":"165","author":"Eberl","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0525","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.4049\/jimmunol.169.3.1340","article-title":"The V alpha 14 NKT cell TCR exhibits high-affinity binding to a glycolipid\/CD1d complex","volume":"169","author":"Sidobre","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0530","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1182\/blood-2008-02-078071","article-title":"B lymphocytes: how they develop and function","volume":"112","author":"LeBien","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0535","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1146\/annurev-immunol-020711-074934","article-title":"Immune regulatory function of B cells","volume":"30","author":"Mauri","year":"2012","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0540","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/ni.2065","article-title":"Crosstalk in NF-kappaB signaling pathways","volume":"12","author":"Oeckinghaus","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0545","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/j.1600-065X.2012.01097.x","article-title":"NF-kappaB regulation: lessons from structures","volume":"246","author":"Ghosh","year":"2012","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0550","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nm1185","article-title":"IKK-beta links inflammation to obesity-induced insulin resistance","volume":"11","author":"Arkan","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0555","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1182\/blood-2008-07-019307","article-title":"TLRs and innate immunity","volume":"113","author":"Beutler","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0560","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1172\/JCI28898","article-title":"TLR4 links innate immunity and fatty acid-induced insulin resistance","volume":"116","author":"Shi","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0565","doi-asserted-by":"crossref","first-page":"16683","DOI":"10.1074\/jbc.M011695200","article-title":"Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4","volume":"276","author":"Lee","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0570","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.2337\/db06-1595","article-title":"Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance","volume":"56","author":"Tsukumo","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0575","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1172\/JCI43378","article-title":"Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice","volume":"121","author":"Holland","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0580","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.cmet.2009.09.006","article-title":"Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice","volume":"10","author":"Saberi","year":"2009","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0585","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.2337\/db11-1595","article-title":"Toll-like receptor 4 deficiency promotes the alternative activation of adipose tissue macrophages","volume":"61","author":"Orr","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0590","doi-asserted-by":"crossref","first-page":"e12537","DOI":"10.1371\/journal.pone.0012537","article-title":"Myeloid differentiation factor 88 (MyD88)-deficiency increases risk of diabetes in mice","volume":"5","author":"Hosoi","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0595","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.bbapap.2009.11.002","article-title":"c-Jun N-terminal kinase (JNK) signaling: recent advances and challenges","volume":"1804","author":"Bogoyevitch","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0600","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.cell.2010.02.034","article-title":"Endoplasmic reticulum stress and the inflammatory basis of metabolic disease","volume":"140","author":"Hotamisligil","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0605","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nature01137","article-title":"A central role for JNK in obesity and insulin resistance","volume":"420","author":"Hirosumi","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0610","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1101\/gad.1216504","article-title":"An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue","volume":"18","author":"Jaeschke","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0615","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.cmet.2007.09.011","article-title":"JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity","volume":"6","author":"Solinas","year":"2007","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0620","doi-asserted-by":"crossref","first-page":"e3151","DOI":"10.1371\/journal.pone.0003151","article-title":"A predominant role for parenchymal c-Jun amino terminal kinase (JNK) in the regulation of systemic insulin sensitivity","volume":"3","author":"Vallerie","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0625","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1126\/science.1160794","article-title":"A stress signaling pathway in adipose tissue regulates hepatic insulin resistance","volume":"322","author":"Sabio","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0630","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1126\/science.1227568","article-title":"JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation","volume":"339","author":"Han","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0635","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/nature10759","article-title":"Inflammasomes in health and disease","volume":"481","author":"Strowig","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0640","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1146\/annurev-immunol-031210-101405","article-title":"The inflammasome NLRs in immunity, inflammation, and associated diseases","volume":"29","author":"Davis","year":"2011","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0645","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/nature08938","article-title":"NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals","volume":"464","author":"Duewell","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0650","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/ni.2022","article-title":"Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling","volume":"12","author":"Wen","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0655","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nm.2279","article-title":"The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance","volume":"17","author":"Vandanmagsar","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0660","doi-asserted-by":"crossref","first-page":"15324","DOI":"10.1073\/pnas.1100255108","article-title":"Inflammasome is a central player in the induction of obesity and insulin resistance","volume":"108","author":"Stienstra","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0665","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1210\/en.2006-0692","article-title":"Interleukin-1beta-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression","volume":"148","author":"Jager","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0670","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1007\/s00125-006-0335-z","article-title":"Long-term treatment with interleukin-1beta induces insulin resistance in murine and human adipocytes","volume":"49","author":"Lagathu","year":"2006","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0675","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.cyto.2008.07.004","article-title":"Treatment with an Interleukin 1 beta antibody improves glycemic control in diet-induced obesity","volume":"44","author":"Osborn","year":"2008","journal-title":"Cytokine"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0680","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1056\/NEJMoa065213","article-title":"Interleukin-1-receptor antagonist in type 2 diabetes mellitus","volume":"356","author":"Larsen","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0685","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1161\/CIRCULATIONAHA.112.122556","article-title":"Effects of interleukin-1beta inhibition with canakinumab on hemoglobin A1c, lipids, C-reactive protein, interleukin-6, and fibrinogen: a phase IIb randomized, placebo-controlled trial","volume":"126","author":"Ridker","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0690","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1172\/JCI10934","article-title":"Insulin\/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways","volume":"107","author":"Rui","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0695","doi-asserted-by":"crossref","first-page":"881","DOI":"10.2337\/diab.45.7.881","article-title":"Effects of an engineered human anti-TNF-alpha antibody (CDP571) on insulin sensitivity and glycemic control in patients with NIDDM","volume":"45","author":"Ofei","year":"1996","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0700","first-page":"1316","article-title":"No increased insulin sensitivity after a single intravenous administration of a recombinant human tumor necrosis factor receptor: Fc fusion protein in obese insulin-resistant patients","volume":"85","author":"Paquot","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0705","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.2337\/db08-1261","article-title":"Interleukin-10 prevents diet-induced insulin resistance by attenuating macrophage and cytokine response in skeletal muscle","volume":"58","author":"Hong","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0710","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/nm0102-75","article-title":"Interleukin-6-deficient mice develop mature-onset obesity","volume":"8","author":"Wallenius","year":"2002","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0715","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.2337\/db08-1475","article-title":"Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice","volume":"58","author":"Fujisaka","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0720","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1007\/s00125-010-2020-5","article-title":"Deficiency of haematopoietic-cell-derived IL-10 does not exacerbate high-fat-diet-induced inflammation or insulin resistance in mice","volume":"54","author":"Kowalski","year":"2011","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0725","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1146\/annurev-immunol-020711-074937","article-title":"The microbiome in infectious disease and inflammation","volume":"30","author":"Honda","year":"2012","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0730","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1172\/JCI58109","article-title":"Gut microbiome, obesity, and metabolic dysfunction","volume":"121","author":"Tilg","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0735","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1038\/nature05894","article-title":"Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance","volume":"447","author":"Odegaard","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0740","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1194\/jlr.M800189-JLR200","article-title":"Preserved glucose tolerance in high-fat-fed C57BL\/6 mice transplanted with PPARgamma\u2212\/\u2212, PPARdelta\u2212\/\u2212, PPARgammadelta\u2212\/\u2212, or LXRalphabeta\u2212\/\u2212 bone marrow","volume":"50","author":"Marathe","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0745","doi-asserted-by":"crossref","first-page":"e1001212","DOI":"10.1371\/journal.pbio.1001212","article-title":"Gut microbiota is a key modulator of insulin resistance in TLR 2 knockout mice","volume":"9","author":"Caricilli","year":"2011","journal-title":"PLoS Biol."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0750","doi-asserted-by":"crossref","first-page":"486","DOI":"10.2337\/db10-0650","article-title":"Selective inactivation of c-Jun NH2-terminal kinase in adipose tissue protects against diet-induced obesity and improves insulin sensitivity in both liver and skeletal muscle in mice","volume":"60","author":"Zhang","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0755","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1038\/oby.2009.445","article-title":"Interleukin-15 contributes to the regulation of murine adipose tissue and human adipocytes","volume":"18","author":"Barra","year":"2010","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0760","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1038\/ijo.2011.168","article-title":"Regulation of glucose\/lipid metabolism and insulin sensitivity by interleukin-4","volume":"36","author":"Chang","year":"2012","journal-title":"Int. J. Obes. (Lond)"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0765","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.2337\/db10-1278","article-title":"Lack of interleukin-1 receptor I (IL-1RI) protects mice from high-fat diet-induced adipose tissue inflammation coincident with improved glucose homeostasis","volume":"60","author":"McGillicuddy","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0770","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1038\/oby.2012.7","article-title":"CX3CR1 deficiency does not influence trafficking of adipose tissue macrophages in mice with diet-induced obesity","volume":"20","author":"Morris","year":"2012","journal-title":"Obesity"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0775","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.1172\/JCI31986","article-title":"Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice","volume":"117","author":"Nomiyama","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0780","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1172\/JCI24335","article-title":"CCR2 modulates inflammatory and metabolic effects of high-fat feeding","volume":"116","author":"Weisberg","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0785","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.cmet.2009.03.002","article-title":"CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance","volume":"9","author":"Chavey","year":"2009","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0790","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.cmet.2008.04.002","article-title":"Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity","volume":"7","author":"Kang","year":"2008","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0795","doi-asserted-by":"crossref","first-page":"12072","DOI":"10.1073\/pnas.1101841108","article-title":"Apoptosis inhibitor of macrophage (AIM) is required for obesity-associated recruitment of inflammatory macrophages into adipose tissue","volume":"108","author":"Kurokawa","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0800","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.2337\/db11-1182","article-title":"The radioprotective 105\/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation","volume":"61","author":"Watanabe","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0805","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1084\/jem.20091333","article-title":"MGL1 promotes adipose tissue inflammation and insulin resistance by regulating 7\/4hi monocytes in obesity","volume":"206","author":"Westcott","year":"2009","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0810","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.2337\/db10-1353","article-title":"Hematopoietic cell-restricted deletion of CD36 reduces high-fat diet-induced macrophage infiltration and improves insulin signaling in adipose tissue","volume":"60","author":"Nicholls","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0815","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.4049\/jimmunol.1100196","article-title":"Deficiency of the leukotriene B4 receptor, BLT-1, protects against systemic insulin resistance in diet-induced obesity","volume":"187","author":"Spite","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0820","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.2337\/db11-0259","article-title":"Macrophage deletion of SOCS1 increases sensitivity to LPS and palmitic acid and results in systemic inflammation and hepatic insulin resistance","volume":"60","author":"Sachithanandan","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0825","doi-asserted-by":"crossref","first-page":"e1000938","DOI":"10.1371\/journal.pgen.1000938","article-title":"Myeloid cell-restricted insulin receptor deficiency protects against obesity-induced inflammation and systemic insulin resistance","volume":"6","author":"Mauer","year":"2010","journal-title":"PLoS Genet."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0830","doi-asserted-by":"crossref","first-page":"22930","DOI":"10.1074\/jbc.M801408200","article-title":"Increased cellular free cholesterol in macrophage-specific Abca1 knock-out mice enhances pro-inflammatory response of macrophages","volume":"283","author":"Zhu","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0835","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nm1550","article-title":"Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance","volume":"13","author":"Lesniewski","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0840","first-page":"2640","article-title":"Adipocyte\/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice","volume":"118","author":"Furuhashi","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0845","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1172\/JCI45444","article-title":"Kruppel-like factor 4 regulates macrophage polarization","volume":"121","author":"Liao","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2013.05.017_bb0850","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.2337\/db07-1751","article-title":"Blockade of alpha4 integrin signaling ameliorates the metabolic consequences of high-fat diet-induced obesity","volume":"57","author":"Feral","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2013.05.017_bb0855","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.cell.2010.07.041","article-title":"GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects","volume":"142","author":"Oh","year":"2010","journal-title":"Cell"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443913001798?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443913001798?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T20:16:27Z","timestamp":1715372187000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443913001798"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":171,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["S0925443913001798"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2013.05.017","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2013.05.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}