{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T07:36:36Z","timestamp":1773300996802,"version":"3.50.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100008907","name":"Oklahoma Medical Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008907","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences (NIEHS)","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.bbadis.2013.08.004","type":"journal-article","created":{"date-parts":[[2013,8,17]],"date-time":"2013-08-17T06:16:24Z","timestamp":1376720184000},"page":"2153-2161","source":"Crossref","is-referenced-by-count":22,"title":["Combined molecular MRI and immuno-spin-trapping for in vivo detection of free radicals in orthotopic mouse GL261 gliomas"],"prefix":"10.1016","volume":"1832","author":[{"given":"Rheal A.","family":"Towner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nataliya","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debra","family":"Saunders","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia Coutinho","family":"De Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leah","family":"Henry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florea","family":"Lupu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Silasi-Mansat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilyn","family":"Ehrenshaft","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald P.","family":"Mason","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra E.","family":"Gomez-Mejiba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario C.","family":"Ramirez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2013.08.004_bb0005","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1002\/ijc.23192","article-title":"Chronic inflammation and oxidative stress in human carcinogenesis","volume":"121","author":"Federico","year":"2007","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bbadis.2013.08.004_bb0010","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/j.freeradbiomed.2004.02.077","article-title":"Using anti-5,5-dimethyl-1-pyrroline N-oxide (anti-DMPO) to detect protein radicals in time and space with immune-spin trapping","volume":"36","author":"Mason","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2013.08.004_bb0015","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.freeradbiomed.2004.10.008","article-title":"Mechanism of hydrogen peroxide-induced Cu, Zn-superoxide dismutase-centered radical formation as explored by immune-spin trapping: the role of copper- and carbonate radical anion-mediated oxidations","volume":"38","author":"Ramirez","year":"2005","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2013.08.004_bb0020","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1042\/BJ20070722","article-title":"Cu, Zn-superoxide dismutase-driven free radical modifications: copper- and carbonate radical anion-initiated protein radical chemistry","volume":"417","author":"Ramirez","year":"2009","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbadis.2013.08.004_bb0025","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S0891-5849(02)00895-X","article-title":"Immunological identification of the heart myoglobin radical formed by hydrogen peroxide","volume":"33","author":"Detweiler","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2013.08.004_bb0030","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/nbm.724","article-title":"MRI and fluorescence microscopy of the acute vascular response to VEGF165: vasodilation, hyper-permeability and lymphatic uptake, followed by rapid inactivation of the growth factor","volume":"15","author":"Dafni","year":"2002","journal-title":"NMR Biomed."},{"key":"10.1016\/j.bbadis.2013.08.004_bb0035","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1582-4934.2008.00220.x","article-title":"In vivo detection of c-Met expression in a rat C6 glioma model","volume":"12","author":"Towner","year":"2008","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.bbadis.2013.08.004_bb0040","series-title":"Bioconjugate Techniques","first-page":"456","author":"Hermanson","year":"1996"},{"key":"10.1016\/j.bbadis.2013.08.004_bb0045","series-title":"Magnetic Resonance Imaging: Physical Principles and Sequence Design","author":"Haacke","year":"1999"},{"key":"10.1016\/j.bbadis.2013.08.004_bb0050","doi-asserted-by":"crossref","first-page":"3238","DOI":"10.1161\/STROKEAHA.111.615559","article-title":"Increased blood\u2013brain barrier permeability and brain edema after focal cerebral ischemia induced by hyperlipidemia: role of lipid peroxidation and calpain-1\/2, matrix metalloproteinase-2\/9, and RhoA overactivation","volume":"42","author":"El Ali","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.bbadis.2013.08.004_bb0055","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.freeradbiomed.2009.12.012","article-title":"In vivo detection of inducible nitric oxide synthase (iNOS) in rodent gliomas","volume":"48","author":"Towner","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2013.08.004_bb0060","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1089\/ten.tea.2009.0234","article-title":"Molecular MRI approaches used to aid in the understanding of the tissue regeneration marker Met in vivo: implications for tissue engineering","volume":"16","author":"Towner","year":"2010","journal-title":"Tissue Eng. Part A"},{"key":"10.1016\/j.bbadis.2013.08.004_bb0065","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1089\/ten.tea.2009.0233","article-title":"Molecular MRI approaches used to aid in the understanding of angiogenesis in vivo: implications for tissue engineering","volume":"16","author":"Towner","year":"2010","journal-title":"Tissue Eng. Part A"},{"key":"10.1016\/j.bbadis.2013.08.004_bb0070","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1111\/j.1582-4934.2010.01091.x","article-title":"Molecular MRI assessment of vascular endothelial growth factor receptor-2 in a rat C6 glioma model","volume":"15","author":"He","year":"2011","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.bbadis.2013.08.004_bb0075","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1084\/jem.20111580","article-title":"Endothelial Wnt\/\u03b2-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression","volume":"209","author":"Reis","year":"2012","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbadis.2013.08.004_bb0080","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.2337\/db11-1540","article-title":"In vivo imaging of immunospin-trapped radicals with molecular magnetic resonance imaging in a mouse diabetes model","volume":"61","author":"Towner","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2013.08.004_bb0085","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1097\/01.cco.0000142485.81849.cc","article-title":"Molecular changes in gliomas","volume":"16","author":"Sanson","year":"2004","journal-title":"Curr. Opin. Oncol."},{"key":"10.1016\/j.bbadis.2013.08.004_bb0090","series-title":"2011 CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2004\u20132007","author":"Central Brain Tumor Registry of the United States (CBTRUS)","year":"2011"},{"key":"10.1016\/j.bbadis.2013.08.004_bb0095","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s11060-004-2751-6","article-title":"Molecular mechanisms of glioma cell migration and invasion","volume":"70","author":"Demuth","year":"2004","journal-title":"J. Neurooncol."},{"key":"10.1016\/j.bbadis.2013.08.004_bb0100","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1053\/j.seminoncol.2004.07.002","article-title":"Altered molecular pathways in gliomas: an overview of clinically relevant issues","volume":"31","author":"Rao","year":"2004","journal-title":"Semin. Oncol."},{"key":"10.1016\/j.bbadis.2013.08.004_bb0105","doi-asserted-by":"crossref","first-page":"511","DOI":"10.3923\/pjbs.2011.511.518","article-title":"A study on the biochemical and cytogenetic status in the blood of glioma patients","volume":"14","author":"Kandavelu","year":"2011","journal-title":"Pak. J. Biol. Sci."},{"key":"10.1016\/j.bbadis.2013.08.004_bb0110","first-page":"1766","article-title":"Mitochondrial dysfunction and effect of antiglycolytic bromopyruvic acid in GL15 glioblastoma cells","volume":"91","author":"Macchioni","year":"2011","journal-title":"Lab. Invest."},{"key":"10.1016\/j.bbadis.2013.08.004_bb0115","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.3109\/10715762.2011.604321","article-title":"Hydrogen peroxide contributes to the manganese superoxide dismutase promotion of migration and invasion in glioma cells","volume":"45","author":"Li","year":"2011","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.bbadis.2013.08.004_bb0120","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0163-7827(93)90006-I","article-title":"Free radical\u2013lipid interactions and their pathological consequences","volume":"32","author":"Rice-Evans","year":"1993","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.bbadis.2013.08.004_bb0125","doi-asserted-by":"crossref","first-page":"7189","DOI":"10.3402\/pba.v1i0.7189","article-title":"The anti-tumor effects of calorie restriction are correlated with reduced oxidative stress in ENU-induced gliomas","volume":"1","author":"Mahlke","year":"2011","journal-title":"Pathobiol. Aging Age Relat. Dis."},{"issue":"4","key":"10.1016\/j.bbadis.2013.08.004_bb0130","doi-asserted-by":"crossref","first-page":"e61195","DOI":"10.1371\/journal.pone.0061195","article-title":"Superoxide mediates direct current electric field-induced directional migration of glioma cells through the activation of AKT and ERK","volume":"8","author":"Li","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2013.08.004_bb0135","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S1357-2725(01)00106-6","article-title":"p53 dependent apoptosis in glioma cell lines in response to hydrogen peroxide induced oxidative stress","volume":"34","author":"Datta","year":"2002","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.bbadis.2013.08.004_bb0140","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/j.1349-7006.2006.00208.x","article-title":"Detailed characterization of the mouse glioma 261 tumor model for experimental glioblastoma therapy","volume":"97","author":"Szatm\u00e1ri","year":"2006","journal-title":"Cancer Sci."},{"key":"10.1016\/j.bbadis.2013.08.004_bb0145","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1177\/030089160909500620","article-title":"Distribution of 4-hydroxynonenal\u2013protein conjugates as a marker of lipid peroxidation and parameter of malignancy in astrocytic and ependymal tumors of the brain","volume":"95","author":"Juric-Sekhar","year":"2009","journal-title":"Tumori"},{"key":"10.1016\/j.bbadis.2013.08.004_bb0150","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/biof.5520240104","article-title":"Immunohistochemical appearance of HNE\u2013protein conjugates in human astrocytomas","volume":"24","author":"Zarkovic","year":"2005","journal-title":"Biofactors"},{"key":"10.1016\/j.bbadis.2013.08.004_bb0155","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s11060-007-9367-6","article-title":"Aldehydic lipid peroxidation products in human brain astrocytomas","volume":"84","author":"Zajdel","year":"2007","journal-title":"J. Neurooncol"},{"key":"10.1016\/j.bbadis.2013.08.004_bb0160","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1017\/S0317167100006715","article-title":"Standardization and detailed characterization of the syngeneic Fisher\/F98 glioma model","volume":"34","author":"Mathieu","year":"2007","journal-title":"Can. J. Neurol. Sci."},{"key":"10.1016\/j.bbadis.2013.08.004_bb0165","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.nucmedbio.2008.06.001","article-title":"Autoradiographic and small-animal PET comparisons between (18)F-FMISO, (18)F-FDG, (18)F-FLT and the hypoxic selective (64)Cu-ATSM in a rodent model of cancer","volume":"35","author":"Dence","year":"2008","journal-title":"Nucl. Med. Biol."},{"key":"10.1016\/j.bbadis.2013.08.004_bb0170","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.nucmedbio.2012.04.006","article-title":"3D tumor spheroids as a model to assess the suitability of [18F]FDG-PET as an early indicator of response to PI3K inhibition","volume":"39","author":"Kelly","year":"2012","journal-title":"Nucl. Med. Biol."},{"key":"10.1016\/j.bbadis.2013.08.004_bb0175","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/cmmi.464","article-title":"In vivo high-resolution 3D Overhauser-enhanced MRI in mice at 0.2T","volume":"7","author":"Massot","year":"2012","journal-title":"Contrast Media Mol. Imaging"},{"key":"10.1016\/j.bbadis.2013.08.004_bb0180","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1002\/mrm.1093","article-title":"Whole body detection and imaging of nitric oxide generation in mice following cardiopulmonary arrest: detection of intrinsic nitrosoheme complexes","volume":"45","author":"Kuppusamy","year":"2001","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.bbadis.2013.08.004_bb0185","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1038\/nbt0896-992","article-title":"In vivo EPR detection and imaging of endogenous nitric oxide in lipopolysaccharide-treated mice","volume":"14","author":"Yoshimura","year":"1996","journal-title":"Nat. Biotechnol."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092544391300269X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092544391300269X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T19:58:43Z","timestamp":1588967923000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S092544391300269X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":37,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S092544391300269X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2013.08.004","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]}}}