{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:21:04Z","timestamp":1791206464250,"version":"4.1.0"},"reference-count":69,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000916","name":"Instituto de Salud Carlos III- Ministerio de Industria y Competitividad de Espa\u00f1a (ISCIII-MINECO, Spain)","doi-asserted-by":"publisher","award":["PS09\/01359"],"award-info":[{"award-number":["PS09\/01359"]}],"id":[{"id":"10.13039\/100000916","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000916","name":"Instituto de Salud Carlos III- Ministerio de Industria y Competitividad de Espa\u00f1a (ISCIII-MINECO, Spain)","doi-asserted-by":"publisher","award":["PI12\/01683"],"award-info":[{"award-number":["PI12\/01683"]}],"id":[{"id":"10.13039\/100000916","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000916","name":"Instituto de Salud Carlos III- Ministerio de Industria y Competitividad de Espa\u00f1a (ISCIII-MINECO, Spain)","doi-asserted-by":"publisher","award":["PI11\/00182"],"award-info":[{"award-number":["PI11\/00182"]}],"id":[{"id":"10.13039\/100000916","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000916","name":"Instituto de Salud Carlos III- Ministerio de Industria y Competitividad de Espa\u00f1a (ISCIII-MINECO, Spain)","doi-asserted-by":"publisher","award":["CP11\/00151"],"award-info":[{"award-number":["CP11\/00151"]}],"id":[{"id":"10.13039\/100000916","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000916","name":"Instituto de Salud Carlos III- Ministerio de Industria y Competitividad de Espa\u00f1a (ISCIII-MINECO, Spain)","doi-asserted-by":"publisher","award":["S2010\/BMD-2361"],"award-info":[{"award-number":["S2010\/BMD-2361"]}],"id":[{"id":"10.13039\/100000916","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000916","name":"Instituto de Salud Carlos III- Ministerio de Industria y Competitividad de Espa\u00f1a (ISCIII-MINECO, Spain)","doi-asserted-by":"publisher","award":["S2010\/BMD-2402"],"award-info":[{"award-number":["S2010\/BMD-2402"]}],"id":[{"id":"10.13039\/100000916","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Comunidad de Madrid (CAM, Spain)"},{"DOI":"10.13039\/100001225","name":"\u2018Miguel Servet\u2019 ISCIII-MINECO (CP11\/00151)","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001225","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006301","name":"(CIBERER-Spain)","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006301","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1016\/j.bbadis.2014.03.013","type":"journal-article","created":{"date-parts":[[2014,4,2]],"date-time":"2014-04-02T01:18:44Z","timestamp":1396401524000},"page":"1059-1070","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Bulk autophagy, but not mitophagy, is increased in cellular model of mitochondrial disease"],"prefix":"10.1016","volume":"1842","author":[{"given":"Mar\u00eda","family":"Mor\u00e1n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aitor","family":"Delmiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Bl\u00e1zquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Ugalde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaqu\u00edn","family":"Arenas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A.","family":"Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2014.03.013_bb0130","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/nm.3232","article-title":"The role of autophagy in neurodegenerative disease","volume":"19","author":"Nixon","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0135","doi-asserted-by":"crossref","first-page":"39068","DOI":"10.1074\/jbc.M406960200","article-title":"Uth1p is involved in the autophagic degradation of mitochondria","volume":"279","author":"Kissova","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0140","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1089\/rej.2005.8.3","article-title":"Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging","volume":"8","author":"Lemasters","year":"2005","journal-title":"Rejuvenation Res."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0145","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1096\/fj.01-0206fje","article-title":"The mitochondrial permeability transition initiates autophagy in rat hepatocytes","volume":"15","author":"Elmore","year":"2001","journal-title":"FASEB J."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0150","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1038\/sj.cdd.4401697","article-title":"Impairing the bioenergetic status and the biogenesis of mitochondria triggers mitophagy in yeast","volume":"12","author":"Priault","year":"2005","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0155","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.abb.2007.03.034","article-title":"Selective degradation of mitochondria by mitophagy","volume":"462","author":"Kim","year":"2007","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0160","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/sj.emboj.7601963","article-title":"Fission and selective fusion govern mitochondrial segregation and elimination by autophagy","volume":"27","author":"Twig","year":"2008","journal-title":"EMBO J."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0165","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1083\/jcb.200809125","article-title":"Parkin is recruited selectively to impaired mitochondria and promotes their autophagy","volume":"183","author":"Narendra","year":"2008","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0170","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1056\/NEJMra1215233","article-title":"Mitochondrial dynamics\u2014mitochondrial fission and fusion in human diseases","volume":"369","author":"Archer","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0175","doi-asserted-by":"crossref","first-page":"4861","DOI":"10.1093\/hmg\/ddq419","article-title":"Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1\/parkin-dependent manner upon induction of mitophagy","volume":"19","author":"Gegg","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0180","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1083\/jcb.201007013","article-title":"Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin","volume":"191","author":"Tanaka","year":"2010","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0185","doi-asserted-by":"crossref","first-page":"e49639","DOI":"10.1371\/journal.pone.0049639","article-title":"Mitochondrial DNA mutations provoke dominant inhibition of mitochondrial inner membrane fusion","volume":"7","author":"Sauvanet","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2014.03.013_bb0190","doi-asserted-by":"crossref","first-page":"10374","DOI":"10.1074\/jbc.M513387200","article-title":"Dysfunctions of cellular oxidative metabolism in patients with mutations in the NDUFS1 and NDUFS4 genes of complex I","volume":"281","author":"Iuso","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0195","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jns.2006.01.021","article-title":"Cerebellar ataxia with coenzyme Q10 deficiency: diagnosis and follow-up after coenzyme Q10 supplementation","volume":"246","author":"Artuch","year":"2006","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0200","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1242\/jcs.03381","article-title":"Mitochondrial bioenergetics and structural network organization","volume":"120","author":"Benard","year":"2007","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0205","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1002\/ana.21385","article-title":"Hereditary optic neuropathies share a common mitochondrial coupling defect","volume":"63","author":"Chevrollier","year":"2008","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0210","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1096\/fj.07-100149","article-title":"Respiratory chain dysfunction and oxidative stress correlate with severity of primary CoQ10 deficiency","volume":"22","author":"Quinzii","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0215","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s00109-009-0452-5","article-title":"The antioxidant Trolox restores mitochondrial membrane potential and Ca2+-stimulated ATP production in human complex I deficiency","volume":"87","author":"Distelmaier","year":"2009","journal-title":"J. Mol. Med. (Berl.)"},{"key":"10.1016\/j.bbadis.2014.03.013_bb0220","doi-asserted-by":"crossref","first-page":"19","DOI":"10.4161\/auto.5.1.7174","article-title":"Coenzyme Q deficiency triggers mitochondria degradation by mitophagy","volume":"5","author":"Rodriguez-Hernandez","year":"2009","journal-title":"Autophagy"},{"key":"10.1016\/j.bbadis.2014.03.013_bb0225","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1096\/fj.10-165340","article-title":"Secondary coenzyme Q10 deficiency triggers mitochondria degradation by mitophagy in MELAS fibroblasts","volume":"25","author":"Cotan","year":"2011","journal-title":"FASEB J."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0230","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1007\/s13311-012-0103-3","article-title":"Recovery of MERRF fibroblasts and cybrids pathophysiology by coenzyme Q(1)(0)","volume":"9","author":"De la Mata","year":"2012","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.bbadis.2014.03.013_bb0235","doi-asserted-by":"crossref","first-page":"17687","DOI":"10.1073\/pnas.0505551102","article-title":"Mutant mitochondrial helicase Twinkle causes multiple mtDNA deletions and a late-onset mitochondrial disease in mice","volume":"102","author":"Tyynismaa","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0240","doi-asserted-by":"crossref","first-page":"3948","DOI":"10.1093\/hmg\/ddq310","article-title":"Mitochondrial myopathy induces a starvation-like response","volume":"19","author":"Tyynismaa","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0245","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1167\/iovs.08-2913","article-title":"OPA1 deficiency associated with increased autophagy in retinal ganglion cells in a murine model of dominant optic atrophy","volume":"50","author":"White","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0250","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/ana.21036","article-title":"X-linked NDUFA1 gene mutations associated with mitochondrial encephalomyopathy","volume":"61","author":"Fernandez-Moreira","year":"2007","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0255","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.bbadis.2010.02.001","article-title":"Mitochondrial bioenergetics and dynamics interplay in complex I-deficient fibroblasts","volume":"1802","author":"Moran","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2014.03.013_bb0260","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1002\/ajmg.a.20171","article-title":"Clinical and diagnostic characteristics of complex III deficiency due to mutations in the BCS1L gene","volume":"121A","author":"De Meirleir","year":"2003","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.bbadis.2014.03.013_bb0265","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.nmd.2008.11.016","article-title":"Infantile mitochondrial encephalomyopathy with unusual phenotype caused by a novel BCS1L mutation in an isolated complex III-deficient patient","volume":"19","author":"Blazquez","year":"2009","journal-title":"Neuromuscul. Disord."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0270","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.mito.2009.04.001","article-title":"Pathogenic mutations in the 5\u2032 untranslated region of BCS1L mRNA in mitochondrial complex III deficiency","volume":"9","author":"Gil-Borlado","year":"2009","journal-title":"Mitochondrion"},{"key":"10.1016\/j.bbadis.2014.03.013_bb0275","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1002\/humu.21294","article-title":"Cellular pathophysiological consequences of BCS1L mutations in mitochondrial complex III enzyme deficiency","volume":"31","author":"Moran","year":"2010","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0280","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/ana.1141","article-title":"Early-onset multisystem mitochondrial disorder caused by a nonsense mutation in the mitochondrial DNA cytochrome C oxidase II gene","volume":"50","author":"Campos","year":"2001","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0285","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.mito.2010.03.003","article-title":"Marked mitochondrial DNA depletion associated with a novel SUCLG1 gene mutation resulting in lethal neonatal acidosis, multi-organ failure, and interrupted aortic arch","volume":"10","author":"Rivera","year":"2010","journal-title":"Mitochondrion"},{"key":"10.1016\/j.bbadis.2014.03.013_bb0290","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0076-6879(08)03601-X","article-title":"Monitoring autophagy in mammalian cultured cells through the dynamics of LC3","volume":"452","author":"Kimura","year":"2009","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0295","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0300","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/978-1-59745-365-3_30","article-title":"Assessing mitochondrial potential, calcium, and redox state in isolated mammalian cells using confocal microscopy","volume":"372","author":"Davidson","year":"2007","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0305","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/S0076-6879(96)64044-0","article-title":"Assessment of mitochondrial oxidative phosphorylation in patient muscle biopsies, lymphoblasts, and transmitochondrial cell lines","volume":"264","author":"Trounce","year":"1996","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0310","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4161\/auto.1.1.1270","article-title":"Maturation of autophagic vacuoles in Mammalian cells","volume":"1","author":"Eskelinen","year":"2005","journal-title":"Autophagy"},{"key":"10.1016\/j.bbadis.2014.03.013_bb0315","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.mam.2006.08.005","article-title":"Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy","volume":"27","author":"Eskelinen","year":"2006","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0320","doi-asserted-by":"crossref","first-page":"257","DOI":"10.4161\/auto.5179","article-title":"To be or not to be? Examples of incorrect identification of autophagic compartments in conventional transmission electron microscopy of mammalian cells","volume":"4","author":"Eskelinen","year":"2008","journal-title":"Autophagy"},{"key":"10.1016\/j.bbadis.2014.03.013_bb0325","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0076-6879(08)03610-0","article-title":"Monitoring autophagy by electron microscopy in Mammalian cells","volume":"452","author":"Yla-Anttila","year":"2009","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0330","doi-asserted-by":"crossref","first-page":"151","DOI":"10.4161\/auto.5338","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes","volume":"4","author":"Klionsky","year":"2008","journal-title":"Autophagy"},{"key":"10.1016\/j.bbadis.2014.03.013_bb0335","doi-asserted-by":"crossref","first-page":"e1000298","DOI":"10.1371\/journal.pbio.1000298","article-title":"PINK1 is selectively stabilized on impaired mitochondria to activate Parkin","volume":"8","author":"Narendra","year":"2010","journal-title":"PLoS Biol."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0340","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1093\/hmg\/ddr529","article-title":"Mitochondrial autophagy in cells with mtDNA mutations results from synergistic loss of transmembrane potential and mTORC1 inhibition","volume":"21","author":"Gilkerson","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0345","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1242\/jcs.103713","article-title":"Increased levels of reduced cytochrome b and mitophagy components are required to trigger nonspecific autophagy following induced mitochondrial dysfunction","volume":"126","author":"Deffieu","year":"2013","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0005","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1038\/emboj.2009.89","article-title":"SLP-2 is required for stress-induced mitochondrial hyperfusion","volume":"28","author":"Tondera","year":"2009","journal-title":"EMBO J."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0010","doi-asserted-by":"crossref","first-page":"11960","DOI":"10.1073\/pnas.0904875106","article-title":"A hyperfused mitochondrial state achieved at G1-S regulates cyclin E buildup and entry into S phase","volume":"106","author":"Mitra","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0015","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/ncb2220","article-title":"During autophagy mitochondria elongate, are spared from degradation and sustain cell viability","volume":"13","author":"Gomes","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0020","doi-asserted-by":"crossref","first-page":"706","DOI":"10.4161\/auto.5.5.8505","article-title":"Parkin-induced mitophagy in the pathogenesis of Parkinson's disease","volume":"5","author":"Narendra","year":"2009","journal-title":"Autophagy"},{"key":"10.1016\/j.bbadis.2014.03.013_bb0025","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.4161\/auto.6.8.13426","article-title":"p62\/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both","volume":"6","author":"Narendra","year":"2010","journal-title":"Autophagy"},{"key":"10.1016\/j.bbadis.2014.03.013_bb0030","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1073\/pnas.0911187107","article-title":"PINK1-dependent recruitment of Parkin to mitochondria in mitophagy","volume":"107","author":"Vives-Bauza","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0035","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1093\/hmg\/ddq531","article-title":"Bioenergetics of neurons inhibit the translocation response of Parkin following rapid mitochondrial depolarization","volume":"20","author":"Van Laar","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0040","doi-asserted-by":"crossref","first-page":"3124","DOI":"10.1093\/hmg\/ddq215","article-title":"Effect of endogenous mutant and wild-type PINK1 on Parkin in fibroblasts from Parkinson disease patients","volume":"19","author":"Rakovic","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0045","doi-asserted-by":"crossref","first-page":"12937","DOI":"10.1073\/pnas.1103295108","article-title":"Impaired mitochondrial transport and Parkin-independent degeneration of respiratory chain-deficient dopamine neurons in vivo","volume":"108","author":"Sterky","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0050","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1093\/hmg\/ddg044","article-title":"Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death","volume":"12","author":"Darios","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0055","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1093\/hmg\/ddl006","article-title":"Parkin enhances mitochondrial biogenesis in proliferating cells","volume":"15","author":"Kuroda","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0060","doi-asserted-by":"crossref","first-page":"3832","DOI":"10.1093\/hmg\/ddp327","article-title":"Parkin protects mitochondrial genome integrity and supports mitochondrial DNA repair","volume":"18","author":"Rothfuss","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0065","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1093\/hmg\/ddr530","article-title":"Parkin interacts with Klokin1 for mitochondrial import and maintenance of membrane potential","volume":"21","author":"Kuroda","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0070","doi-asserted-by":"crossref","first-page":"6400","DOI":"10.1073\/pnas.1221132110","article-title":"The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo","volume":"110","author":"Vincow","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0075","doi-asserted-by":"crossref","first-page":"6252","DOI":"10.1073\/pnas.1303921110","article-title":"Sequestration and autophagy of mitochondria do not cut proteins across the board","volume":"110","author":"Huang","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0080","doi-asserted-by":"crossref","first-page":"e17412","DOI":"10.1371\/journal.pone.0017412","article-title":"Starvation induced cell death in autophagy-defective yeast mutants is caused by mitochondria dysfunction","volume":"6","author":"Suzuki","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2014.03.013_bb0085","doi-asserted-by":"crossref","first-page":"e41156","DOI":"10.1371\/journal.pone.0041156","article-title":"Metabolite profiles reveal energy failure and impaired beta-oxidation in liver of mice with complex III deficiency due to a BCS1L mutation","volume":"7","author":"Kotarsky","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2014.03.013_bb0090","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1136\/jclinpath-2012-201431","article-title":"Mitochondrial myopathy with autophagic vacuoles in patients with the m.8344A>G mutation","volume":"66","author":"Yuan","year":"2013","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0095","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1038\/nature09076","article-title":"Termination of autophagy and reformation of lysosomes regulated by mTOR","volume":"465","author":"Yu","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2014.03.013_bb0100","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1038\/emboj.2011.104","article-title":"Mitochondria regulate autophagy by conserved signalling pathways","volume":"30","author":"Graef","year":"2011","journal-title":"EMBO J."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0105","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/BF00489903","article-title":"Energy-dependent lysosomal wrapping mechanism (LWM) during autophagolysosome formation","volume":"76","author":"Sakai","year":"1982","journal-title":"Histochemistry"},{"key":"10.1016\/j.bbadis.2014.03.013_bb0110","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1432-1033.1987.tb11011.x","article-title":"Energy dependence of autophagic protein degradation in isolated rat hepatocytes","volume":"164","author":"Plomp","year":"1987","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0115","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1007\/BF01041376","article-title":"Energy depletion and autophagy. Cytochemical and biochemical studies in isolated rat hepatocytes","volume":"23","author":"Schellens","year":"1991","journal-title":"Histochem. J."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0120","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1515\/bchm.1998.379.11.1341","article-title":"Inhibition of hepatocytic autophagy by adenosine, adenosine analogs and AMP","volume":"379","author":"Kovacs","year":"1998","journal-title":"Biol. Chem."},{"key":"10.1016\/j.bbadis.2014.03.013_bb0125","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1042\/BJ20121122","article-title":"Glucose induces autophagy under starvation conditions by a p38 MAPK-dependent pathway","volume":"449","author":"Moruno-Manchon","year":"2013","journal-title":"Biochem. J."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443914000854?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443914000854?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T00:19:26Z","timestamp":1565309966000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443914000854"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":69,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["S0925443914000854"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2014.03.013","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bulk autophagy, but not mitophagy, is increased in cellular model of mitochondrial disease","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2014.03.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}