{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:21:22Z","timestamp":1790292082546,"version":"4.1.0"},"reference-count":69,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"vor","delay-in-days":366,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1016\/j.bbadis.2015.01.011","type":"journal-article","created":{"date-parts":[[2015,1,23]],"date-time":"2015-01-23T07:31:51Z","timestamp":1421998311000},"page":"749-758","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["Palmitoyl-carnitine increases RyR2 oxidation and sarcoplasmic reticulum Ca2+ leak in cardiomyocytes: Role of adenine nucleotide translocase"],"prefix":"10.1016","volume":"1852","author":[{"given":"J.","family":"Roussel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Thireau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Brenner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Saint","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Scheuermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Lacampagne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.-Y.","family":"Le Guennec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Fauconnier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2015.01.011_bb0005","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.bbalip.2005.03.005","article-title":"Fatty acid metabolism is enhanced in type 2 diabetic hearts","volume":"1734","author":"Carley","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2015.01.011_bb0010","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1152\/physrev.00015.2009","article-title":"Myocardial fatty acid metabolism in health and disease","volume":"90","author":"Lopaschuk","year":"2010","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0015","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1079\/PNS2003336","article-title":"The role of uncoupling protein 3 in fatty acid metabolism: protection against lipotoxicity?","volume":"63","author":"Schrauwen","year":"2004","journal-title":"Proc. Nutr. Soc."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0020","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1432-1033.1989.tb14867.x","article-title":"The ATP\/ADP-antiporter is involved in the uncoupling effect of fatty acids on mitochondria","volume":"182","author":"Andreyev","year":"1989","journal-title":"Eur. J. Biochem. FEBS"},{"key":"10.1016\/j.bbadis.2015.01.011_bb0025","doi-asserted-by":"crossref","first-page":"5288","DOI":"10.1111\/j.1742-4658.2006.05523.x","article-title":"Metabolic control of mitochondrial properties by adenine nucleotide translocator determines palmitoyl-CoA effects. Implications for a mechanism linking obesity and type 2 diabetes","volume":"273","author":"Ciapaite","year":"2006","journal-title":"FEBS J."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0030","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0014-5793(91)81382-I","article-title":"Uncoupling effect of fatty acids on heart muscle mitochondria and submitochondrial particles","volume":"295","author":"Dedukhova","year":"1991","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2337\/db12-0466","article-title":"Acylcarnitines: reflecting or inflicting insulin resistance?","volume":"62","author":"Schooneman","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2015.01.011_bb0040","doi-asserted-by":"crossref","first-page":"H1489","DOI":"10.1152\/ajpheart.00278.2006","article-title":"Role of changes in cardiac metabolism in development of diabetic cardiomyopathy","volume":"291","author":"An","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0045","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.cccn.2005.04.029","article-title":"Plasma and urinary carnitine and acylcarnitines in chronic fatigue syndrome","volume":"360","author":"Jones","year":"2005","journal-title":"Clin. Chim. Acta Int. J. Clin. Chem."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0050","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/ajmg.c.30087","article-title":"Disorders of carnitine transport and the carnitine cycle","volume":"142C","author":"Longo","year":"2006","journal-title":"Am. J. Med. Genet. C: Semin. Med. Genet."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0055","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1042\/bj2140021","article-title":"Observations on the affinity for carnitine, and malonyl-CoA sensitivity, of carnitine palmitoyltransferase I in animal and human tissues. Demonstration of the presence of malonyl-CoA in non-hepatic tissues of the rat","volume":"214","author":"McGarry","year":"1983","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0060","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1172\/JCI113978","article-title":"Prophylaxis of early ventricular fibrillation by inhibition of acylcarnitine accumulation","volume":"83","author":"Corr","year":"1989","journal-title":"J. Clin. Invest."},{"issue":"Suppl. 1","key":"10.1016\/j.bbadis.2015.01.011_bb0065","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0022-2828(91)90019-I","article-title":"Amphipathic lipid metabolites and their relation to arrhythmogenesis in the ischemic heart","volume":"23","author":"DaTorre","year":"1991","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0070","first-page":"385","article-title":"Mitochondrial cardiomyopathy: pathophysiology, diagnosis, and management","volume":"40","author":"Meyers","year":"2013","journal-title":"Tex. Heart Inst. J."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0075","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.1073\/pnas.1300690110","article-title":"Severity of cardiomyopathy associated with adenine nucleotide translocator-1 deficiency correlates with mtDNA haplogroup","volume":"110","author":"Strauss","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0080","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.2337\/db06-0739","article-title":"Effects of palmitate on Ca(2+) handling in adult control and ob\/ob cardiomyocytes: impact of mitochondrial reactive oxygen species","volume":"56","author":"Fauconnier","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2015.01.011_bb0085","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1124\/jpet.109.151936","article-title":"The late Na+current (INa) inhibitor ranolazine attenuates effects of palmitoyl-L-carnitine to increase late INa and cause ventricular diastolic dysfunction","volume":"330","author":"Wu","year":"2009","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0090","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.cardiores.2006.02.019","article-title":"Redox regulation of cardiac calcium channels and transporters","volume":"71","author":"Zima","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0095","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1161\/CIRCRESAHA.108.184457","article-title":"Redox modification of ryanodine receptors contributes to sarcoplasmic reticulum Ca2+ leak in chronic heart failure","volume":"103","author":"Terentyev","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0100","doi-asserted-by":"crossref","first-page":"6976","DOI":"10.1074\/jbc.M607590200","article-title":"Redox sensitivity of the ryanodine receptor interaction with FK506-binding protein","volume":"282","author":"Zissimopoulos","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0105","doi-asserted-by":"crossref","first-page":"553","DOI":"10.2741\/3705","article-title":"Modulation of cardiac ryanodine receptor activity by ROS and RNS","volume":"16","author":"Donoso","year":"2011","journal-title":"Front. Biosci. (Landmark Ed.)"},{"key":"10.1016\/j.bbadis.2015.01.011_bb0110","first-page":"H2405","article-title":"Palmitoylcarnitine increases [Na+]i and initiates transient inward current in adult ventricular myocytes","volume":"268","author":"Wu","year":"1995","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0115","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1084\/jem.193.4.509","article-title":"Control of mitochondrial membrane permeabilization by adenine nucleotide translocator interacting with HIV-1 viral protein rR and Bcl-2","volume":"193","author":"Jacotot","year":"2001","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0120","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1113\/jphysiol.2003.034231","article-title":"Ischaemic preconditioning inhibits opening of mitochondrial permeability transition pores in the reperfused rat heart","volume":"549","author":"Javadov","year":"2003","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0125","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/S0006-291X(88)80940-9","article-title":"Increase in the ADP\/ATP exchange in rat liver mitochondria irradiated in vitro by helium\u2013neon laser","volume":"156","author":"Passarella","year":"1988","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0130","doi-asserted-by":"crossref","first-page":"3550","DOI":"10.2741\/3470","article-title":"Pharmacological screening and enzymatic assays for apoptosis","volume":"14","author":"Belzacq-Casagrande","year":"2009","journal-title":"Front. Biosci. (Landmark Ed.)"},{"key":"10.1016\/j.bbadis.2015.01.011_bb0135","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jmgm.2013.08.016","article-title":"Identification of adenine nucleotide translocase 4 inhibitors by molecular docking","volume":"45","author":"Leung","year":"2013","journal-title":"J. Mol. Graph. Model."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0140","doi-asserted-by":"crossref","first-page":"C1073","DOI":"10.1152\/ajpcell.00586.2006","article-title":"SparkMaster: automated calcium spark analysis with ImageJ","volume":"293","author":"Picht","year":"2007","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0145","doi-asserted-by":"crossref","first-page":"13258","DOI":"10.1073\/pnas.1100286108","article-title":"Ryanodine receptor leak mediated by caspase-8 activation leads to left ventricular injury after myocardial ischemia-reperfusion","volume":"108","author":"Fauconnier","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0150","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/cvr\/cvs167","article-title":"Functional evidence for an active role of B-type natriuretic peptide in cardiac remodelling and pro-arrhythmogenicity","volume":"95","author":"Thireau","year":"2012","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0155","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1073\/pnas.0908540107","article-title":"Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy","volume":"107","author":"Fauconnier","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"Pt 2","key":"10.1016\/j.bbadis.2015.01.011_bb0160","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1042\/bj3360287","article-title":"Direct demonstration of a specific interaction between cyclophilin-D and the adenine nucleotide translocase confirms their role in the mitochondrial permeability transition","volume":"336","author":"Woodfield","year":"1998","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0165","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1006\/jmcc.1999.0968","article-title":"Palmitoyl carnitine increases intracellular calcium in adult rat cardiomyocytes","volume":"31","author":"Netticadan","year":"1999","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0170","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1161\/01.RES.51.2.142","article-title":"Transient depolarization and spontaneous voltage fluctuations in isolated single cells from guinea pig ventricles. Calcium-mediated membrane potential fluctuations","volume":"51","author":"Matsuda","year":"1982","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0175","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.pharmthera.2013.04.008","article-title":"The Lambeth Conventions (II): guidelines for the study of animal and human ventricular and supraventricular arrhythmias","volume":"139","author":"Curtis","year":"2013","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0180","doi-asserted-by":"crossref","first-page":"944","DOI":"10.2337\/diabetes.54.4.944","article-title":"Modular kinetic analysis of the adenine nucleotide translocator-mediated effects of palmitoyl-CoA on the oxidative phosphorylation in isolated rat liver mitochondria","volume":"54","author":"Ciapaite","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2015.01.011_bb0185","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0021-9150(99)00329-9","article-title":"Cytosolic triglycerides and oxidative stress in central obesity: the missing link between excessive atherosclerosis, endothelial dysfunction, and beta-cell failure?","volume":"148","author":"Bakker","year":"2000","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.bbadis.2015.01.011_bb0190","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.bbabio.2007.04.005","article-title":"Fatty acids decrease mitochondrial generation of reactive oxygen species at the reverse electron transport but increase it at the forward transport","volume":"1767","author":"Schonfeld","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2015.01.011_bb0195","first-page":"H663","article-title":"Adenine nucleotide transport during cardiac ischemia","volume":"241","author":"LaNoue","year":"1981","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0200","doi-asserted-by":"crossref","first-page":"6711","DOI":"10.1016\/S0021-9258(17)39907-6","article-title":"Reversible inhibition of adenine nucleotide translocation by long chain acyl-CoA esters in bovine heart mitochondria and inverted submitochondrial particles. Comparison with atractylate and bongkrekic acid","volume":"252","author":"Chua","year":"1977","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0205","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1161\/01.HYP.0000254415.31362.a7","article-title":"Role of oxidative stress in cardiac hypertrophy and remodeling","volume":"49","author":"Takimoto","year":"2007","journal-title":"Hypertension"},{"key":"10.1016\/j.bbadis.2015.01.011_bb0210","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0092-8674(00)00054-4","article-title":"The skeletal muscle calcium release channel: coupled O2 sensor and NO signaling functions","volume":"102","author":"Eu","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2015.01.011_bb0215","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/S0006-2952(98)00360-8","article-title":"Regulation of ryanodine receptors by reactive nitrogen species","volume":"57","author":"Eu","year":"1999","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0220","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1126\/science.279.5348.234","article-title":"Activation of the cardiac calcium release channel (ryanodine receptor) by poly-S-nitrosylation","volume":"279","author":"Xu","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2015.01.011_bb0225","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1093\/cvr\/cvm012","article-title":"Does nitric oxide modulate cardiac ryanodine receptor function? Implications for excitation\u2013contraction coupling","volume":"77","author":"Lim","year":"2008","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0230","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S1063-5823(10)66005-X","article-title":"Regulation of ryanodine receptor ion channels through posttranslational modifications","volume":"66","author":"Meissner","year":"2010","journal-title":"Curr. Top. Membr."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0235","doi-asserted-by":"crossref","first-page":"18186","DOI":"10.1073\/pnas.1210565109","article-title":"Aberrant S-nitrosylation mediates calcium-triggered ventricular arrhythmia in the intact heart","volume":"109","author":"Cutler","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0240","doi-asserted-by":"crossref","first-page":"20612","DOI":"10.1073\/pnas.0706796104","article-title":"Deficient ryanodine receptor S-nitrosylation increases sarcoplasmic reticulum calcium leak and arrhythmogenesis in cardiomyocytes","volume":"104","author":"Gonzalez","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0245","doi-asserted-by":"crossref","first-page":"22961","DOI":"10.1074\/jbc.M113.480228","article-title":"Oxygen-coupled redox regulation of the skeletal muscle ryanodine receptor\/Ca2+ release channel (RyR1): sites and nature of oxidative modification","volume":"288","author":"Sun","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0250","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0092-8674(00)80847-8","article-title":"PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts","volume":"101","author":"Marx","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2015.01.011_bb0255","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1161\/hh1101.091193","article-title":"Arrhythmogenesis and contractile dysfunction in heart failure: roles of sodium\u2013calcium exchange, inward rectifier potassium current, and residual beta-adrenergic responsiveness","volume":"88","author":"Pogwizd","year":"2001","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0260","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.cardiores.2005.05.024","article-title":"Ca2+-dependent reduction of IK1 in rat ventricular cells: a novel paradigm for arrhythmia in heart failure?","volume":"68","author":"Fauconnier","year":"2005","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0265","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1161\/01.RES.82.9.947","article-title":"Dynamic Ca2+-induced inward rectification of K+ current during the ventricular action potential","volume":"82","author":"Zaza","year":"1998","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0270","doi-asserted-by":"crossref","first-page":"3633","DOI":"10.1161\/CIRCULATIONAHA.105.555623","article-title":"Correction of defective interdomain interaction within ryanodine receptor by antioxidant is a new therapeutic strategy against heart failure","volume":"112","author":"Yano","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.bbadis.2015.01.011_bb0275","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1159\/000333127","article-title":"Primary carnitine deficiency and sudden death: in vivo evidence of myocardial lipid peroxidation and sulfonylation of sarcoendoplasmic reticulum calcium ATPase 2","volume":"120","author":"Mazzini","year":"2011","journal-title":"Cardiology"},{"key":"10.1016\/j.bbadis.2015.01.011_bb0280","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1152\/physrev.00006.2004","article-title":"Myocardial substrate metabolism in the normal and failing heart","volume":"85","author":"Stanley","year":"2005","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0285","doi-asserted-by":"crossref","first-page":"5234","DOI":"10.1021\/bi047773a","article-title":"Accumulation of long-chain acylcarnitine and 3-hydroxy acylcarnitine molecular species in diabetic myocardium: identification of alterations in mitochondrial fatty acid processing in diabetic myocardium by shotgun lipidomics","volume":"44","author":"Su","year":"2005","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbadis.2015.01.011_bb0290","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1016\/j.jacc.2013.03.061","article-title":"Mitochondrial dysfunction as an arrhythmogenic substrate: a translational proof-of-concept study in patients with metabolic syndrome in whom post-operative atrial fibrillation develops","volume":"62","author":"Montaigne","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0295","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1161\/01.CIR.100.22.2248","article-title":"Arrhythmias and conduction defects as presenting symptoms of fatty acid oxidation disorders in children","volume":"100","author":"Bonnet","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.bbadis.2015.01.011_bb0300","first-page":"365","article-title":"Role of adenine nucleotide translocase in metabolic change caused by ischemia","volume":"10","author":"Shug","year":"1975","journal-title":"Recent Adv. Stud. Cardiac Struct. Metab."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0305","first-page":"H25","article-title":"Protective role of adenine nucleotide translocase in O2-deficient hearts","volume":"247","author":"Pande","year":"1984","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0310","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1139\/y89-114","article-title":"Relationship between oxidative phosphorylation and adenine nucleotide translocase activity of two populations of cardiac mitochondria and mechanical recovery of ischemic hearts following reperfusion","volume":"67","author":"Duan","year":"1989","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0315","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.pharmthera.2013.01.015","article-title":"Type 2 ryanodine receptor: a novel therapeutic target in myocardial ischemia\/reperfusion","volume":"138","author":"Fauconnier","year":"2013","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0320","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1016\/j.ijcard.2012.04.150","article-title":"Disturbed carnitine regulation in chronic heart failure\u2014increased plasma levels of palmitoyl-carnitine are associated with poor prognosis","volume":"167","author":"Ueland","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0325","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.1093\/hmg\/ddi341","article-title":"Complete loss-of-function of the heart\/muscle-specific adenine nucleotide translocator is associated with mitochondrial myopathy and cardiomyopathy","volume":"14","author":"Palmieri","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0330","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/ng0797-226","article-title":"A mouse model for mitochondrial myopathy and cardiomyopathy resulting from a deficiency in the heart\/muscle isoform of the adenine nucleotide translocator","volume":"16","author":"Graham","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0335","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1136\/jmedgenet-2011-100504","article-title":"Complete loss of expression of the ANT1 gene causing cardiomyopathy and myopathy","volume":"49","author":"Echaniz-Laguna","year":"2012","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0340","doi-asserted-by":"crossref","first-page":"4820","DOI":"10.1073\/pnas.96.9.4820","article-title":"Mitochondrial disease in mouse results in increased oxidative stress","volume":"96","author":"Esposito","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2015.01.011_bb0345","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0014-2999(95)00701-6","article-title":"Protective effects of free polyunsaturated fatty acids on arrhythmias induced by lysophosphatidylcholine or palmitoylcarnitine in neonatal rat cardiac myocytes","volume":"297","author":"Kang","year":"1996","journal-title":"Eur. J. Pharmacol."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443915000204?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443915000204?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T10:15:03Z","timestamp":1651054503000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443915000204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":69,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["S0925443915000204"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2015.01.011","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Palmitoyl-carnitine increases RyR2 oxidation and sarcoplasmic reticulum Ca2+ leak in cardiomyocytes: Role of adenine nucleotide translocase","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2015.01.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}