{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T22:27:57Z","timestamp":1787783277002,"version":"build-2784847793"},"reference-count":28,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Institute of Cardiometabolism and Nutrition (ICAN)","award":["ANR-10-IAHU-05"],"award-info":[{"award-number":["ANR-10-IAHU-05"]}]},{"DOI":"10.13039\/501100004431","name":"Fondation de France","doi-asserted-by":"publisher","award":["2012-00029516"],"award-info":[{"award-number":["2012-00029516"]}],"id":[{"id":"10.13039\/501100004431","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004923","name":"AFM-T\u00e9l\u00e9thon (camIR)","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001674","name":"Fondation Leducq","doi-asserted-by":"publisher","award":["12CVD02"],"award-info":[{"award-number":["12CVD02"]}],"id":[{"id":"10.13039\/501100001674","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.bbadis.2016.01.010","type":"journal-article","created":{"date-parts":[[2016,1,13]],"date-time":"2016-01-13T17:48:27Z","timestamp":1452707307000},"page":"611-621","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["miR-322 regulates insulin signaling pathway and protects against metabolic syndrome-induced cardiac dysfunction in mice"],"prefix":"10.1016","volume":"1862","author":[{"given":"Alexandre","family":"Marchand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Atassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Mougenot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Clergue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Codoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Berthuin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Proust","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David-Alexandre","family":"Tr\u00e9gou\u00ebt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-S\u00e9bastien","family":"Hulot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Marie","family":"Lompr\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bbadis.2016.01.010_bb0005","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1139\/h06-099","article-title":"Metabolic syndrome and its association with morbidity and mortality","volume":"32","author":"Ardern","year":"2007","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"10.1016\/j.bbadis.2016.01.010_bb0010","doi-asserted-by":"crossref","first-page":"3530","DOI":"10.2337\/diabetes.54.12.3530","article-title":"Unraveling the temporal pattern of diet-induced insulin resistance in individual organs and cardiac dysfunction in C57BL\/6 mice","volume":"54","author":"Park","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2016.01.010_bb0015","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.tem.2011.05.001","article-title":"New insights into insulin resistance in the diabetic heart","volume":"22","author":"Gray","year":"2011","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.bbadis.2016.01.010_bb0020","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.cmet.2013.06.004","article-title":"MicroRNAs and metabolism crosstalk in energy homeostasis","volume":"18","author":"Dumortier","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbadis.2016.01.010_bb0025","doi-asserted-by":"crossref","first-page":"21075","DOI":"10.1073\/pnas.1118922109","article-title":"Control of glucose homeostasis and insulin sensitivity by the Let-7 family of microRNAs","volume":"108","author":"Frost","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2016.01.010_bb0030","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/ncb2211","article-title":"Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism","volume":"13","author":"Jordan","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbadis.2016.01.010_bb0035","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/nature10112","article-title":"MicroRNAs 103 and 107 regulate insulin sensitivity","volume":"474","author":"Trajkovski","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2016.01.010_bb0040","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nature11793","article-title":"Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b","volume":"494","author":"Kornfeld","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2016.01.010_bb0045","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1093\/cvr\/cvq010","article-title":"MicroRNA-223 regulates Glut4 expression and cardiomyocyte glucose metabolism","volume":"86","author":"Lu","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbadis.2016.01.010_bb0050","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.cell.2012.03.029","article-title":"A cardiac microRNA governs systemic energy homeostasis by regulation of MED13","volume":"149","author":"Grueter","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2016.01.010_bb0055","doi-asserted-by":"crossref","first-page":"14264","DOI":"10.1074\/jbc.M112.432104","article-title":"MicroRNA-322 (miR-322) and its target protein Tob2 modulate Osterix (Osx) mRNA stability","volume":"288","author":"Gamez","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2016.01.010_bb0060","doi-asserted-by":"crossref","first-page":"19849","DOI":"10.1073\/pnas.0706963104","article-title":"The interplay between the master transcription factor PU.1 and miR-424 regulates human monocyte\/macrophage differentiation","volume":"104","author":"Rosa","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2016.01.010_bb0065","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1091\/mbc.E10-01-0062","article-title":"MiR-322\/424 and \u2212503 are induced during muscle differentiation and promote cell cycle quiescence and differentiation by down-regulation of Cdc25A","volume":"21","author":"Sarkar","year":"2010","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbadis.2016.01.010_bb0070","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1093\/cvr\/cvt045","article-title":"miR-424\/322 regulates vascular smooth muscle cell phenotype and neointimal formation in the rat","volume":"98","author":"Merlet","year":"2013","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbadis.2016.01.010_bb0075","doi-asserted-by":"crossref","DOI":"10.2202\/1544-6115.1027","article-title":"Linear models and empirical bayes methods for assessing differential expression in microarray experiments","volume":"3","author":"Smyth","year":"2004","journal-title":"Stat. Appl. Genet. Mol. Biol."},{"key":"10.1016\/j.bbadis.2016.01.010_bb0080","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.fob.2012.04.003","article-title":"GeneSetDB: a comprehensive meta-database, statistical and visualisation framework for gene set analysis","volume":"2","author":"Araki","year":"2012","journal-title":"FEBS Open Biol."},{"key":"10.1016\/j.bbadis.2016.01.010_bb0085","doi-asserted-by":"crossref","first-page":"31995","DOI":"10.1074\/jbc.M110.124164","article-title":"SIRT4 regulates fatty acid oxidation and mitochondrial gene expression in liver and muscle cells","volume":"285","author":"Nasrin","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2016.01.010_bb0090","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.cell.2006.06.057","article-title":"SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells","volume":"126","author":"Haigis","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2016.01.010_bb0095","doi-asserted-by":"crossref","first-page":"e60931","DOI":"10.1371\/journal.pone.0060931","article-title":"Mice long-term high-fat diet feeding recapitulates human cardiovascular alterations: an animal model to study the early phases of diabetic cardiomyopathy","volume":"8","author":"Calligaris","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bbadis.2016.01.010_bb0100","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1161\/CIRCULATIONAHA.111.031229","article-title":"Critical role for stromal interaction molecule 1 in cardiac hypertrophy","volume":"124","author":"Hulot","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.bbadis.2016.01.010_bb0105","doi-asserted-by":"crossref","first-page":"e84425","DOI":"10.1371\/journal.pone.0084425","article-title":"Differentially expressed wound healing-related microRNAs in the human diabetic cornea","volume":"8","author":"Funari","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bbadis.2016.01.010_bb0110","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1016\/j.cjca.2013.07.002","article-title":"MicroRNA deregulation in right ventricular outflow tract myocardium in nonsyndromic tetralogy of fallot","volume":"29","author":"Zhang","year":"2013","journal-title":"Can. J. Cardiol."},{"key":"10.1016\/j.bbadis.2016.01.010_bb0115","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1755-5922.2009.00120.x","article-title":"Insulin signaling: a possible pathogenesis of cardiac hypertrophy","volume":"28","author":"Yu","year":"2010","journal-title":"Cardiovasc. Ther."},{"key":"10.1016\/j.bbadis.2016.01.010_bb0120","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1172\/JCI24178","article-title":"Protein kinase cascades in the regulation of cardiac hypertrophy","volume":"115","author":"Dorn","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2016.01.010_bb0125","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.cell.2011.08.033","article-title":"The Lin28\/let-7 axis regulates glucose metabolism","volume":"147","author":"Zhu","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2016.01.010_bb0130","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1161\/CIRCULATIONAHA.113.008476","article-title":"Myocardial contractile dysfunction is associated with impaired mitochondrial function and dynamics in type 2 diabetic but not in obese patients","volume":"130","author":"Montaigne","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.bbadis.2016.01.010_bb0135","doi-asserted-by":"crossref","first-page":"5341","DOI":"10.1210\/en.2005-0938","article-title":"Reduced cardiac efficiency and altered substrate metabolism precedes the onset of hyperglycemia and contractile dysfunction in two mouse models of insulin resistance and obesity","volume":"146","author":"Buchanan","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbadis.2016.01.010_bb0140","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.2337\/diabetes.53.9.2366","article-title":"Impaired cardiac efficiency and increased fatty acid oxidation in insulin-resistant ob\/ob mouse hearts","volume":"53","author":"Mazumder","year":"2004","journal-title":"Diabetes"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443916000119?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443916000119?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,16]],"date-time":"2018-09-16T06:28:56Z","timestamp":1537079336000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443916000119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["S0925443916000119"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2016.01.010","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"miR-322 regulates insulin signaling pathway and protects against metabolic syndrome-induced cardiac dysfunction in mice","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2016.01.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}