{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T20:33:16Z","timestamp":1785875596898,"version":"3.56.0"},"reference-count":97,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health (NIH)","doi-asserted-by":"crossref","award":["R01 NS044310"],"award-info":[{"award-number":["R01 NS044310"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100003927","name":"Luke and Rachel Batten Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100003927","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.bbadis.2016.04.011","type":"journal-article","created":{"date-parts":[[2016,4,22]],"date-time":"2016-04-22T16:43:26Z","timestamp":1461343406000},"page":"1324-1336","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Antigen presenting cell abnormalities in the Cln3 \u2212\/\u2212 mouse model of juvenile neuronal ceroid lipofuscinosis"],"prefix":"10.1016","volume":"1862","author":[{"given":"Samantha L.","family":"Hersrud","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attila D.","family":"Kov\u00e1cs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Pearce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2016.04.011_bb0005","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1750-3639.2004.tb00499.x","article-title":"Current state of clinical and morphological features in human NCL","volume":"14","author":"Goebel","year":"2004","journal-title":"Brain Pathol."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0010","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.brainres.2004.07.030","article-title":"Late onset neurodegeneration in the Cln3\u2212\/\u2212 mouse model of juvenile neuronal ceroid lipofuscinosis is preceded by low level glial activation","volume":"1023","author":"Pontikis","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0015","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1750-3639.2004.tb00077.x","article-title":"Hippocampal pathology in the human neuronal ceroid-lipofuscinoses: distinct patterns of storage deposition, neurodegeneration and glial activation","volume":"14","author":"Tyynela","year":"2004","journal-title":"Brain Pathol."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0020","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.brainres.2009.02.009","article-title":"Cerebellar defects in a mouse model of juvenile neuronal ceroid lipofuscinosis","volume":"1266","author":"Weimer","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0025","doi-asserted-by":"crossref","first-page":"79","DOI":"10.2217\/clp.11.70","article-title":"The juvenile Batten disease protein, CLN3, and its role in regulating anterograde and retrograde post-Golgi trafficking","volume":"7","author":"Cotman","year":"2012","journal-title":"Clin. Lipidol."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0030","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.nbd.2007.08.007","article-title":"Identification of alpha-fetoprotein as an autoantigen in juvenile Batten disease","volume":"29","author":"Castaneda","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0035","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1093\/hmg\/11.12.1421","article-title":"An autoantibody inhibitory to glutamic acid decarboxylase in the neurodegenerative disorder Batten disease","volume":"11","author":"Chattopadhyay","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0040","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1212\/01.WNL.0000041913.97883.8B","article-title":"An autoantibody to GAD65 in sera of patients with juvenile neuronal ceroid lipofuscinoses","volume":"59","author":"Chattopadhyay","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.bbadis.2016.04.011_bb0045","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.nbd.2006.09.005","article-title":"IgG entry and deposition are components of the neuroimmune response in Batten disease","volume":"25","author":"Lim","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0050","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jneuroim.2010.08.024","article-title":"Immunosuppression alters disease severity in juvenile Batten disease mice","volume":"230","author":"Seehafer","year":"2011","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0055","first-page":"S78","article-title":"Glia impair neuron health in juvenile neuronal ceroid lipofuscinosis","volume":"61","author":"Lange","year":"2013","journal-title":"Glia"},{"key":"10.1016\/j.bbadis.2016.04.011_bb0060","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/jnc.12385","article-title":"Microglia in juvenile neuronal ceroid lipofuscinosis are primed toward a pro-inflammatory phenotype","volume":"127","author":"Xiong","year":"2013","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0038310","article-title":"Large-scale phenotyping of an accurate genetic mouse model of JNCL identifies novel early pathology outside the central nervous system","volume":"7","author":"Staropoli","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2016.04.011_bb0070","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1242\/jcs.00235","article-title":"Phosphoinositide-3-kinase-independent contractile activities associated with Fcgamma-receptor-mediated phagocytosis and macropinocytosis in macrophages","volume":"116","author":"Araki","year":"2003","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0075","doi-asserted-by":"crossref","first-page":"2882","DOI":"10.1002\/jnr.21416","article-title":"Progressive oxidative damage in the central nervous system of a murine model for juvenile Batten disease","volume":"85","author":"Benedict","year":"2007","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0080","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1242\/jcs.100032","article-title":"Supervillin couples myosin-dependent contractility to podosomes and enables their turnover","volume":"125","author":"Bhuwania","year":"2012","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0085","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.hoc.2009.01.007","article-title":"Shwachman-Diamond syndrome: a review of the clinical presentation, molecular pathogenesis, diagnosis, and treatment","volume":"23","author":"Burroughs","year":"2009","journal-title":"Hematol. Oncol. Clin. N. Am."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0090","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.yexcr.2010.09.007","article-title":"A novel interaction of CLN3 with nonmuscle myosin-IIB and defects in cell motility of Cln3\u2212\/\u2212 cells","volume":"317","author":"Getty","year":"2011","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0095","doi-asserted-by":"crossref","first-page":"4451","DOI":"10.1182\/blood-2012-01-407098","article-title":"DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses","volume":"119","author":"Harada","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.bbadis.2016.04.011_bb0100","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1111\/j.1600-0854.2010.01102.x","article-title":"Cdc42 and vesicle trafficking in polarized cells","volume":"11","author":"Harris","year":"2010","journal-title":"Traffic"},{"key":"10.1016\/j.bbadis.2016.04.011_bb0105","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1083\/jcb.200908086","article-title":"Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling","volume":"188","author":"Koivusalo","year":"2010","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0110","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1007\/s00223-001-1112-0","article-title":"Differential localization of myosin II isoforms in resting and activated osteoclasts","volume":"71","author":"Krits","year":"2002","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0115","doi-asserted-by":"crossref","first-page":"5703","DOI":"10.1182\/blood-2008-11-191882","article-title":"Cdc42-dependent leading edge coordination is essential for interstitial dendritic cell migration","volume":"113","author":"Lammermann","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.bbadis.2016.04.011_bb0120","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0096647","article-title":"CLN3 deficient cells display defects in the ARF1-Cdc42 pathway and actin-dependent events","volume":"9","author":"Schultz","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2016.04.011_bb0125","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/cm.10164","article-title":"The chemotaxis defect of Shwachman-Diamond syndrome leukocytes","volume":"57","author":"Stepanovic","year":"2004","journal-title":"Cell Motil. Cytoskeleton"},{"key":"10.1016\/j.bbadis.2016.04.011_bb0130","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1093\/hmg\/ddp560","article-title":"Interaction between Sdo1p and Btn1p in the Saccharomyces cerevisiae model for Batten disease","volume":"19","author":"Vitiello","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0135","doi-asserted-by":"crossref","first-page":"3853","DOI":"10.1182\/blood-2007-03-079582","article-title":"Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis","volume":"110","author":"Yang","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.bbadis.2016.04.011_bb0140","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1203\/PDR.0b013e31816fdc17","article-title":"CLN3p impacts galactosylceramide transport, raft morphology, and lipid content","volume":"63","author":"Rusyn","year":"2008","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0145","doi-asserted-by":"crossref","first-page":"18065","DOI":"10.1523\/JNEUROSCI.0498-13.2013","article-title":"CLN3 loss disturbs membrane microdomain properties and protein transport in brain endothelial cells","volume":"33","author":"Tecedor","year":"2013","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0150","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1016\/j.yexcr.2008.06.016","article-title":"Novel interactions of CLN3 protein link Batten disease to dysregulation of fodrin-Na+, K+ ATPase complex","volume":"314","author":"Uusi-Rauva","year":"2008","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0155","doi-asserted-by":"crossref","first-page":"5659","DOI":"10.4049\/jimmunol.177.8.5659","article-title":"Differential expression of CD11c by peripheral blood NK cells reflects temporal activity of multiple sclerosis","volume":"177","author":"Aranami","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0160","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.1002\/eji.200838342","article-title":"Altered dendritic cells with tolerizing phenotype in patients with systemic lupus erythematosus","volume":"38","author":"Berkun","year":"2008","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0165","doi-asserted-by":"crossref","first-page":"R68","DOI":"10.1186\/ar2985","article-title":"B cells from rheumatoid arthritis patients show important alterations in the expression of CD86 and FcgammaRIIb, which are modulated by anti-tumor necrosis factor therapy","volume":"12","author":"Catalan","year":"2010","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0170","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1006\/clin.1997.4353","article-title":"Analysis of CD80 and CD86 expression on peripheral blood B lymphocytes reveals increased expression of CD86 in lupus patients","volume":"83","author":"Folzenlogen","year":"1997","journal-title":"Clin. Immunol. Immunopathol."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0175","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0092-8674(02)00971-6","article-title":"Integrins: bidirectional, allosteric signaling machines","volume":"110","author":"Hynes","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2016.04.011_bb0180","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1084\/jem.20051503","article-title":"Selective dysregulation of the FcgammaIIB receptor on memory B cells in SLE","volume":"203","author":"Mackay","year":"2006","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0185","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1189\/jlb.0507287","article-title":"Extracellular survivin up-regulates adhesion molecules on the surface of leukocytes changing their reactivity pattern","volume":"83","author":"Mera","year":"2008","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0190","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1172\/JCI23049","article-title":"T cell hyperactivity in lupus as a consequence of hyperstimulatory antigen-presenting cells","volume":"115","author":"Zhu","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0195","first-page":"161","article-title":"Leukocyte CD11\/CD18 integrins: biological and clinical relevance","volume":"80","author":"Mazzone","year":"1995","journal-title":"Haematologica"},{"key":"10.1016\/j.bbadis.2016.04.011_bb0200","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1042\/BSR20110101","article-title":"The leucocyte beta2 (CD18) integrins: the structure, functional regulation and signalling properties","volume":"32","author":"Tan","year":"2012","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0205","doi-asserted-by":"crossref","first-page":"C1232","DOI":"10.1152\/ajpcell.00008.2006","article-title":"ICAM-1 expression in adipose tissue: effects of diet-induced obesity in mice","volume":"291","author":"Brake","year":"2006","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0210","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1210\/jc.2005-2327","article-title":"Increased activation of nuclear factor kappaB triggers inflammation and insulin resistance in polycystic ovary syndrome","volume":"91","author":"Gonzalez","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0215","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1172\/JCI29881","article-title":"Obesity induces a phenotypic switch in adipose tissue macrophage polarization","volume":"117","author":"Lumeng","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0220","doi-asserted-by":"crossref","first-page":"35279","DOI":"10.1074\/jbc.M706762200","article-title":"A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways","volume":"282","author":"Nguyen","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0225","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.cmet.2008.08.015","article-title":"Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals","volume":"8","author":"Patsouris","year":"2008","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0230","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.4049\/jimmunol.174.5.2612","article-title":"Natural killer dendritic cells have both antigen presenting and lytic function and in response to CpG produce IFN-gamma via autocrine IL-12","volume":"174","author":"Pillarisetty","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0235","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1161\/CIRCULATIONAHA.108.823740","article-title":"Functional role of CD11c+monocytes in atherogenesis associated with hypercholesterolemia","volume":"119","author":"Wu","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.bbadis.2016.04.011_bb0240","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0165-5728(90)90055-R","article-title":"Brain microglia constitutively express beta-2 integrins","volume":"30","author":"Akiyama","year":"1990","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0245","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/1465-9921-6-70","article-title":"The beta2 integrin CD11c distinguishes a subset of cytotoxic pulmonary T cells with potent antiviral effects in vitro and in vivo","volume":"6","author":"Beyer","year":"2005","journal-title":"Respir. Res."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0250","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1182\/blood-2011-01-331462","article-title":"Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c(+) B-cell population is important for the development of autoimmunity","volume":"118","author":"Rubtsov","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.bbadis.2016.04.011_bb0255","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1096\/fasebj.13.13.1855","article-title":"A role for beta(2) integrins (CD11\/CD18) in the regulation of cytokine gene expression of polymorphonuclear neutrophils during the inflammatory response","volume":"13","author":"Walzog","year":"1999","journal-title":"FASEB J."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0260","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1006\/nbdi.1999.0267","article-title":"Targeted disruption of the Cln3 gene provides a mouse model for Batten disease. The Batten mouse model consortium [corrected]","volume":"6","author":"Mitchison","year":"1999","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0265","doi-asserted-by":"crossref","first-page":"13566","DOI":"10.1073\/pnas.251485198","article-title":"Disruption of PPT1 or PPT2 causes neuronal ceroid lipofuscinosis in knockout mice","volume":"98","author":"Gupta","year":"2001","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.bbadis.2016.04.011_bb0270","doi-asserted-by":"crossref","first-page":"9117","DOI":"10.1523\/JNEUROSCI.2729-04.2004","article-title":"A mouse model of classical late-infantile neuronal ceroid lipofuscinosis based on targeted disruption of the CLN2 gene results in a loss of tripeptidyl-peptidase I activity and progressive neurodegeneration","volume":"24","author":"Sleat","year":"2004","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0275","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nri1394","article-title":"Neonatal adaptive immunity comes of age","volume":"4","author":"Adkins","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0280","series-title":"Guide for the Care and Use of Laboratory Animals","author":"Academies, N.R.C.o.t.N.","year":"2011"},{"key":"10.1016\/j.bbadis.2016.04.011_bb0285","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0022-1759(98)00204-X","article-title":"An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow","volume":"223","author":"Lutz","year":"1999","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.bbadis.2016.04.011_bb0290","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.vaccine.2012.10.114","article-title":"Anti-melanoma vaccinal capacity of CD11c-positive and -negative cell populations present in GM-CSF cultures derived from murine bone marrow precursors","volume":"31","author":"Campisano","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.bbadis.2016.04.011_bb0295","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.1073\/pnas.90.7.3038","article-title":"Granulocytes, macrophages, and dendritic cells arise from a common major histocompatibility complex class II-negative progenitor in mouse bone marrow","volume":"90","author":"Inaba","year":"1993","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.bbadis.2016.04.011_bb0300","doi-asserted-by":"crossref","unstructured":"Zhang, X., Goncalves, R. and Mosser, D.M. (2008) The isolation and characterization of murine macrophages. Current protocols in immunology\/edited by John E. Coligan \u2026 et al., (Chapter 14, Unit 14 11).","DOI":"10.1002\/0471142735.im1401s83"},{"key":"10.1016\/j.bbadis.2016.04.011_bb0305","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1093\/hmg\/ddt120","article-title":"The role of nonsense-mediated decay in neuronal ceroid lipofuscinosis","volume":"22","author":"Miller","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0310","first-page":"626","article-title":"Rectangular confidence regions for the means of multivariate normal distributions","volume":"62","author":"Sidak","year":"1967","journal-title":"J. Am. Stat. Assoc."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0315","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1080\/01621459.1961.10482090","article-title":"Multiple comparisons among means","volume":"56","author":"Dunn","year":"1961","journal-title":"J. Am. Stat. Assoc."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0320","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1002\/cyto.a.20896","article-title":"Quantifying colocalization by correlation: the Pearson correlation coefficient is superior to the Mander's overlap coefficient","volume":"77","author":"Adler","year":"2010","journal-title":"Cytometry A"},{"key":"10.1016\/j.bbadis.2016.04.011_bb0325","series-title":"Current protocols in cell biology","article-title":"Quantitative colocalization analysis of confocal fluorescence microscopy images","author":"Zinchuk","year":"2011"},{"key":"10.1016\/j.bbadis.2016.04.011_bb0330","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S1074-7613(03)00174-2","article-title":"Blood monocytes consist of two principal subsets with distinct migratory properties","volume":"19","author":"Geissmann","year":"2003","journal-title":"Immunity"},{"key":"10.1016\/j.bbadis.2016.04.011_bb0335","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1182\/blood-2002-03-0974","article-title":"Dendritic cell precursor populations of mouse blood: identification of the murine homologues of human blood plasmacytoid pre-DC2 and CD11c+DC1 precursors","volume":"101","author":"O'Keeffe","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.bbadis.2016.04.011_bb0340","doi-asserted-by":"crossref","first-page":"4410","DOI":"10.4049\/jimmunol.172.7.4410","article-title":"Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory response","volume":"172","author":"Sunderkotter","year":"2004","journal-title":"J. Immunol."},{"issue":"Pt 3","key":"10.1016\/j.bbadis.2016.04.011_bb0345","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1242\/jcs.108.3.1003","article-title":"Differential localization of protein kinase C isozymes in U937 cells: evidence for distinct isozyme functions during monocyte differentiation","volume":"108","author":"Kiley","year":"1995","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0350","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1172\/JCI113102","article-title":"Stimulated mobilization of monocyte Mac-1 and p150,95 adhesion proteins from an intracellular vesicular compartment to the cell surface","volume":"80","author":"Miller","year":"1987","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0355","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1126\/science.183.4125.656","article-title":"Cholera toxin: interaction of subunits with ganglioside GM1","volume":"183","author":"Heyningen","year":"1974","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2016.04.011_bb0360","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/0092-8674(92)90143-Z","article-title":"Caveolin, a protein component of caveolae membrane coats","volume":"68","author":"Rothberg","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2016.04.011_bb0365","first-page":"491","article-title":"The sensing of membrane microdomains based on pore-forming toxins","volume":"20","author":"Skocaj","year":"2013","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0370","first-page":"451","article-title":"Down's syndrome lymphoid cell lines exhibit increased adhesion due to the over-expression of lymphocyte function-associated antigen (LFA-1)","volume":"64","author":"Taylor","year":"1988","journal-title":"Immunology"},{"key":"10.1016\/j.bbadis.2016.04.011_bb0375","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1093\/brain\/awt020","article-title":"Immune cells perturb axons and impair neuronal survival in a mouse model of infantile neuronal ceroid lipofuscinosis","volume":"136","author":"Groh","year":"2013","journal-title":"Brain J. Neurol."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0380","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/35036052","article-title":"Lipid rafts and signal transduction","volume":"1","author":"Simons","year":"2000","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0385","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1203\/01.PDR.0000136152.54638.95","article-title":"A galactosylceramide binding domain is involved in trafficking of CLN3 from Golgi to rafts via recycling endosomes","volume":"56","author":"Persaud-Sawin","year":"2004","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0390","doi-asserted-by":"crossref","first-page":"5793","DOI":"10.1091\/mbc.E05-05-0413","article-title":"Dynamic partitioning into lipid rafts controls the endo-exocytic cycle of the alphaL\/beta2 integrin, LFA-1, during leukocyte chemotaxis","volume":"16","author":"Fabbri","year":"2005","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbadis.2016.04.011_bb0395","doi-asserted-by":"crossref","first-page":"3695","DOI":"10.1242\/jcs.095810","article-title":"Integrin trafficking at a glance","volume":"125","author":"Bridgewater","year":"2012","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0400","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1471-2202-5-57","article-title":"Membrane trafficking and mitochondrial abnormalities precede subunit c deposition in a cerebellar cell model of juvenile neuronal ceroid lipofuscinosis","volume":"5","author":"Fossale","year":"2004","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0405","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1006\/mgme.2000.3006","article-title":"CLN3 protein regulates lysosomal pH and alters intracellular processing of Alzheimer's amyloid-beta protein precursor and cathepsin D in human cells","volume":"70","author":"Golabek","year":"2000","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0410","doi-asserted-by":"crossref","first-page":"5851","DOI":"10.1046\/j.0014-2956.2001.02530.x","article-title":"Elevated lysosomal pH in neuronal ceroid lipofuscinoses (NCLs)","volume":"268","author":"Holopainen","year":"2001","journal-title":"Eur. J. Biochem.\/FEBS"},{"key":"10.1016\/j.bbadis.2016.04.011_bb0415","doi-asserted-by":"crossref","first-page":"10273","DOI":"10.1074\/jbc.M510625200","article-title":"Saccharomyces cerevisiae Lacking Btn1p modulate vacuolar ATPase activity to regulate pH imbalance in the vacuole","volume":"281","author":"Padilla-Lopez","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0420","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1161\/ATVBAHA.109.198044","article-title":"CD11c expression in adipose tissue and blood and its role in diet-induced obesity","volume":"30","author":"Wu","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0425","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S1074-7613(02)00290-X","article-title":"CD40L blockade prevents autoimmune diabetes by induction of bitypic NK\/DC regulatory cells","volume":"16","author":"Homann","year":"2002","journal-title":"Immunity"},{"key":"10.1016\/j.bbadis.2016.04.011_bb0430","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/clpt.2009.244","article-title":"CD11c as a transcriptional biomarker to predict response to anti-TNF monotherapy with adalimumab in patients with rheumatoid arthritis","volume":"87","author":"Stuhlmuller","year":"2010","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0435","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s10545-012-9508-8","article-title":"Characterisation of the T cell and dendritic cell repertoire in a murine model of mucopolysaccharidosis I (MPS I)","volume":"36","author":"Archer","year":"2013","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0440","doi-asserted-by":"crossref","first-page":"10018","DOI":"10.1073\/pnas.1200941109","article-title":"Gaucher disease gene GBA functions in immune regulation","volume":"109","author":"Liu","year":"2012","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.bbadis.2016.04.011_bb0445","first-page":"475","article-title":"Coexistence of Fabry's disease and systemic lupus erythematosus","volume":"16","author":"Rahman","year":"1998","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0450","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1182\/blood-2013-03-488692","article-title":"Altered distribution and function of natural killer cells in murine and human Niemann\u2013Pick disease type C1","volume":"123","author":"Speak","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.bbadis.2016.04.011_bb0455","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1007\/s00467-006-0176-5","article-title":"IgA nephropathy in two adolescent sisters heterozygous for Fabry disease","volume":"21","author":"Whybra","year":"2006","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0460","doi-asserted-by":"crossref","first-page":"4645","DOI":"10.1182\/blood.V86.12.4645.bloodjournal86124645","article-title":"Impaired microbicidal capacity of mononuclear phagocytes from patients with type I Gaucher disease: partial correction by enzyme replacement therapy","volume":"86","author":"Marodi","year":"1995","journal-title":"Blood"},{"key":"10.1016\/j.bbadis.2016.04.011_bb0465","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/nrn1032","article-title":"The impact of systemic infection on the progression of neurodegenerative disease","volume":"4","author":"Perry","year":"2003","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0470","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1002\/ana.10143","article-title":"Flupirtine blocks apoptosis in Batten patient lymphoblasts and in human postmitotic CLN3- and CLN2-deficient neurons","volume":"51","author":"Dhar","year":"2002","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0475","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.nbd.2009.07.010","article-title":"Beneficial effects of anti-inflammatory therapy in a mouse model of Niemann\u2013Pick disease type C1","volume":"36","author":"Smith","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0480","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.nbd.2014.03.001","article-title":"Improved neuroprotection using miglustat, curcumin and ibuprofen as a triple combination therapy in Niemann\u2013Pick disease type C1 mice","volume":"67","author":"Williams","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbadis.2016.04.011_bb0485","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1007\/s10545-011-9346-0","article-title":"Parent-reported benefits of flupirtine in juvenile neuronal ceroid lipofuscinosis (Batten disease; CLN3) are not supported by quantitative data","volume":"34","author":"Cialone","year":"2011","journal-title":"J. Inherit. Metab. Dis."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443916300886?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443916300886?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,18]],"date-time":"2022-06-18T12:28:12Z","timestamp":1655555292000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443916300886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":97,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["S0925443916300886"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2016.04.011","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antigen presenting cell abnormalities in the Cln3\u2212\/\u2212 mouse model of juvenile neuronal ceroid lipofuscinosis","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2016.04.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V.","name":"copyright","label":"Copyright"}]}}