{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T17:22:43Z","timestamp":1784395363957,"version":"3.55.0"},"reference-count":68,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"National Science Centre of Poland","doi-asserted-by":"publisher","award":["2011\/01\/B\/NZ4\/03719"],"award-info":[{"award-number":["2011\/01\/B\/NZ4\/03719"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004281","name":"National Science Centre of Poland","doi-asserted-by":"publisher","award":["2015\/17\/N\/NZ4\/028410"],"award-info":[{"award-number":["2015\/17\/N\/NZ4\/028410"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001870","name":"Foundation for Polish Science","doi-asserted-by":"publisher","award":["TEAM\/2011-8\/7"],"award-info":[{"award-number":["TEAM\/2011-8\/7"]}],"id":[{"id":"10.13039\/501100001870","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["H2020 - ERC-2014-PoC 641232"],"award-info":[{"award-number":["H2020 - ERC-2014-PoC 641232"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.bbadis.2016.08.019","type":"journal-article","created":{"date-parts":[[2016,8,31]],"date-time":"2016-08-31T02:18:53Z","timestamp":1472609933000},"page":"2147-2157","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["An impaired metabolism of nucleotides underpins a novel mechanism of cardiac remodeling leading to Huntington's disease related cardiomyopathy"],"prefix":"10.1016","volume":"1862","author":[{"given":"Marta","family":"Toczek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Zielonka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina","family":"Zukowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerzy T.","family":"Marcinkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Slominska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Isalan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryszard T.","family":"Smolenski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Mielcarek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2016.08.019_bb0005","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.parkreldis.2014.12.013","article-title":"Update on Huntington's disease: advances in care and emerging therapeutic options","volume":"21","author":"Zielonka","year":"2015","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.bbadis.2016.08.019_bb0010","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/0896-6273(93)90127-D","article-title":"Huntington's disease gene (IT15) is widely expressed in human and rat tissues","volume":"11","author":"Li","year":"1993","journal-title":"Neuron"},{"key":"10.1016\/j.bbadis.2016.08.019_bb0015","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0092-8674(00)80513-9","article-title":"Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation","volume":"90","author":"Davies","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2016.08.019_bb0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0008025","article-title":"Formation of polyglutamine inclusions in a wide range of non-CNS tissues in the HdhQ150 knock-in mouse model of Huntington's disease","volume":"4","author":"Moffitt","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2016.08.019_bb0025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004550","article-title":"Dysfunction of the CNS-heart axis in mouse models of Huntington's disease","volume":"10","author":"Mielcarek","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.bbadis.2016.08.019_bb0030","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0968-0004(03)00168-3","article-title":"The hunt for huntingtin function: interaction partners tell many different stories","volume":"28","author":"Harjes","year":"2003","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.bbadis.2016.08.019_bb0035","first-page":"2547","article-title":"Cardiac dysfunction in Huntington's disease","volume":"20","author":"Zielonka","year":"2014","journal-title":"Exp. Clin. Cardiol."},{"key":"10.1016\/j.bbadis.2016.08.019_bb0040","article-title":"Huntington's disease and the heart: electrocardiogram abnormalities suggest cardiac involvement","volume":"84","author":"Stephen","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.bbadis.2016.08.019_bb0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0108961","article-title":"The Huntington's disease-related cardiomyopathy prevents a hypertrophic response in the R6\/2 mouse model","volume":"9","author":"Mielcarek","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2016.08.019_bb0050","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1161\/CIRCRESAHA.112.265660","article-title":"Mitochondria as a drug target in ischemic heart disease and cardiomyopathy","volume":"111","author":"Walters","year":"2012","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbadis.2016.08.019_bb0055","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.ijcard.2014.11.014","article-title":"Cardiac manifestations of primary mitochondrial disorders","volume":"177","author":"Finsterer","year":"2014","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.bbadis.2016.08.019_bb0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0112971","article-title":"Heart mitochondrial proteome study elucidates changes in cardiac energy metabolism and antioxidant PRDX3 in human dilated cardiomyopathy","volume":"9","author":"Rosello-Lleti","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2016.08.019_bb0065","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1161\/CIRCRESAHA.113.302095","article-title":"Cardiac metabolism and its interactions with contraction, growth, and survival of cardiomyocytes","volume":"113","author":"Kolwicz","year":"2013","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbadis.2016.08.019_bb0070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1005021","article-title":"HDAC4-myogenin axis as an important marker of HD-related skeletal muscle atrophy","volume":"11","author":"Mielcarek","year":"2015","journal-title":"PLoS Genet."},{"key":"10.1016\/j.bbadis.2016.08.019_bb0075","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/S0378-4347(00)82125-8","article-title":"Determination of sixteen nucleotides, nucleosides and bases using high-performance liquid chromatography and its application to the study of purine metabolism in hearts for transplantation","volume":"527","author":"Smolenski","year":"1990","journal-title":"J. Chromatogr."},{"key":"10.1016\/j.bbadis.2016.08.019_bb0080","doi-asserted-by":"crossref","first-page":"H1468","DOI":"10.1152\/ajpheart.00624.2004","article-title":"Effects of chronic administration of clenbuterol on function and metabolism of adult rat cardiac muscle","volume":"288","author":"Soppa","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bbadis.2016.08.019_bb0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0027746","article-title":"SAHA decreases HDAC 2 and 4 levels in vivo and improves molecular phenotypes in the R6\/2 mouse model of Huntington's disease","volume":"6","author":"Mielcarek","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2016.08.019_bb0090","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","article-title":"Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice","volume":"87","author":"Mangiarini","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2016.08.019_bb0095","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/hmg\/10.2.137","article-title":"Neurological abnormalities in a knock-in mouse model of Huntington's disease","volume":"10","author":"Lin","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbadis.2016.08.019_bb0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10409230590918577","article-title":"Relating structure to mechanism in creatine kinase","volume":"40","author":"McLeish","year":"2005","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"10.1016\/j.bbadis.2016.08.019_bb0105","first-page":"573","article-title":"Exercise stress test and comparison of ST change with cardiac nucleotide catabolite production in patients with coronary artery disease","volume":"14","author":"Burakowski","year":"2007","journal-title":"Cardiol. J."},{"key":"10.1016\/j.bbadis.2016.08.019_bb0110","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1101\/gad.17420111","article-title":"AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function","volume":"25","author":"Hardie","year":"2011","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbadis.2016.08.019_bb0115","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1186\/1471-2164-15-800","article-title":"Comparative genomics of nucleotide metabolism: a tour to the past of the three cellular domains of life","volume":"15","author":"Armenta-Medina","year":"2014","journal-title":"BMC Genomics"},{"key":"10.1016\/j.bbadis.2016.08.019_bb0120","first-page":"2475","article-title":"Enzymic capacities of purine de novo and salvage pathways for nucleotide synthesis in normal and neoplastic tissues","volume":"44","author":"Natsumeda","year":"1984","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbadis.2016.08.019_bb0125","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1006\/abio.1995.1101","article-title":"Enzymatic synthesis of guanine nucleotides labeled with 15N at the 2-amino group of the purine ring","volume":"225","author":"Bouhss","year":"1995","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bbadis.2016.08.019_bb0130","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S0925-4439(99)00032-0","article-title":"Synthesis of adenine and guanine nucleotides at the \u2018inosinic branch point\u2019 in lymphocytes of leukemia patients","volume":"1454","author":"Carlucci","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2016.08.019_bb0135","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.3390\/ijms10041729","article-title":"Adenylate kinase and AMP signaling networks: metabolic monitoring, signal communication and body energy sensing","volume":"10","author":"Dzeja","year":"2009","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2016.08.019_bb0140","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1080\/15257770.2014.880478","article-title":"Extracellular nucleotide catabolism in aortoiliac bifurcation of atherosclerotic ApoE\/LDLr double knock out mice","volume":"33","author":"Kutryb-Zajac","year":"2014","journal-title":"Nucleosides Nucleotides Nucleic Acids"},{"key":"10.1016\/j.bbadis.2016.08.019_bb0145","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.2174\/092986709788803114","article-title":"Dipeptidyl peptidase-4 (CD26): knowing the function before inhibiting the enzyme","volume":"16","author":"Matteucci","year":"2009","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bbadis.2016.08.019_bb0150","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1080\/15257770.2014.880479","article-title":"Extracellular adenine nucleotide catabolism in heart valves","volume":"33","author":"Toczek","year":"2014","journal-title":"Nucleosides Nucleotides Nucleic Acids"},{"key":"10.1016\/j.bbadis.2016.08.019_bb0155","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/S0008-6363(00)00222-4","article-title":"Increased activity of membrane-associated nucleoside diphosphate kinase and inhibition of cAMP synthesis in failing human myocardium","volume":"49","author":"Lutz","year":"2001","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbadis.2016.08.019_bb0160","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1080\/15257770.2011.630852","article-title":"Purine nucleoside phosphorylase deficiency: a mutation update","volume":"30","author":"Walker","year":"2011","journal-title":"Nucleosides Nucleotides Nucleic Acids"},{"key":"10.1016\/j.bbadis.2016.08.019_bb0165","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1291\/hypres.31.931","article-title":"Associations of hypertension and its complications with variations in the xanthine dehydrogenase gene","volume":"31","author":"Yang","year":"2008","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.bbadis.2016.08.019_bb0170","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/cdd.2014.173","article-title":"Hexokinase II integrates energy metabolism and cellular protection: akting on mitochondria and TORCing to autophagy","volume":"22","author":"Roberts","year":"2015","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbadis.2016.08.019_bb0175","doi-asserted-by":"crossref","first-page":"380","DOI":"10.3389\/fphys.2014.00380","article-title":"Skeletal muscle pathology in Huntington's disease","volume":"5","author":"Zielonka","year":"2014","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbadis.2016.08.019_bb0180","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.nbd.2006.09.016","article-title":"Cardiac dysfunction in the R6\/2 mouse model of Huntington's disease","volume":"25","author":"Mihm","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbadis.2016.08.019_bb0185","doi-asserted-by":"crossref","first-page":"5845","DOI":"10.1113\/jphysiol.2012.238113","article-title":"Neurocardiac dysregulation and neurogenic arrhythmias in a transgenic mouse model of Huntington's disease","volume":"590","author":"Kiriazis","year":"2012","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbadis.2016.08.019_bb0190","article-title":"Cardiac fas-dependent and mitochondria-dependent apoptotic pathways in a transgenic mouse model of Huntington's disease","author":"Wu","year":"2015","journal-title":"Cardiovasc. Toxicol."},{"key":"10.1016\/j.bbadis.2016.08.019_bb0195","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s40169-015-0076-z","article-title":"A shared mechanism of muscle wasting in cancer and Huntington's disease","volume":"4","author":"Mielcarek","year":"2015","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.bbadis.2016.08.019_bb0200","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1002\/mds.20373","article-title":"Mitochondrial impairment in patients and asymptomatic mutation carriers of Huntington's disease","volume":"20","author":"Saft","year":"2005","journal-title":"Mov. Disord."},{"key":"10.1016\/j.bbadis.2016.08.019_bb0205","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1038\/sj.cdd.4401967","article-title":"Increased apoptosis, huntingtin inclusions and altered differentiation in muscle cell cultures from Huntington's disease subjects","volume":"13","author":"Ciammola","year":"2006","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbadis.2016.08.019_bb0210","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/0140-6736(91)91838-L","article-title":"Detection of low phosphocreatine to ATP ratio in failing hypertrophied human myocardium by 31P magnetic resonance spectroscopy","volume":"338","author":"Conway","year":"1991","journal-title":"Lancet"},{"key":"10.1016\/j.bbadis.2016.08.019_bb0215","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1023\/A:1006876031121","article-title":"Human myocardial ATP content and in vivo contractile function","volume":"180","author":"Starling","year":"1998","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.bbadis.2016.08.019_bb0220","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.1073\/pnas.1300690110","article-title":"Severity of cardiomyopathy associated with adenine nucleotide translocator-1 deficiency correlates with mtDNA haplogroup","volume":"110","author":"Strauss","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2016.08.019_bb0225","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1046\/j.1365-2362.1999.00468.x","article-title":"Energetics and function of the failing human heart with dilated or hypertrophic cardiomyopathy","volume":"29","author":"Kalsi","year":"1999","journal-title":"Eur. J. Clin. Investig."},{"key":"10.1016\/j.bbadis.2016.08.019_bb0230","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1161\/01.CIR.85.2.420","article-title":"Signal transduction by G proteins in cardiac tissues","volume":"85","author":"Fleming","year":"1992","journal-title":"Circulation"},{"key":"10.1016\/j.bbadis.2016.08.019_bb0235","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1590\/S1679-45082014RB2741","article-title":"Role of the phosphocreatine system on energetic homeostasis in skeletal and cardiac muscles","volume":"12","author":"Guimaraes-Ferreira","year":"2014","journal-title":"Einstein"},{"key":"10.1016\/j.bbadis.2016.08.019_bb0240","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1161\/01.CIR.91.6.1824","article-title":"Enalapril treatment increases cardiac performance and energy reserve via the creatine kinase reaction in myocardium of Syrian myopathic hamsters with advanced heart failure","volume":"91","author":"Nascimben","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.bbadis.2016.08.019_bb0245","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1172\/JCI1940","article-title":"Diastolic dysfunction and altered energetics in the alphaMHC403\/+ mouse model of familial hypertrophic cardiomyopathy","volume":"101","author":"Spindler","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2016.08.019_bb0250","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.expneurol.2011.05.024","article-title":"Bioenergetic dysfunction in Huntington's disease human cybrids","volume":"231","author":"Ferreira","year":"2011","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbadis.2016.08.019_bb0255","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.tem.2014.11.001","article-title":"Is AMPK the savior of the failing heart?","volume":"26","author":"Kim","year":"2015","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.bbadis.2016.08.019_bb0260","doi-asserted-by":"crossref","first-page":"32207","DOI":"10.1074\/jbc.M606357200","article-title":"Dissecting the role of 5\u2032-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase","volume":"281","author":"Suter","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2016.08.019_bb0265","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1161\/CIRCRESAHA.110.223115","article-title":"Reduction in hexokinase II levels results in decreased cardiac function and altered remodeling after ischemia\/reperfusion injury","volume":"108","author":"Wu","year":"2011","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbadis.2016.08.019_bb0270","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.cbpa.2006.09.014","article-title":"Metabolic and genetic regulation of cardiac energy substrate preference","volume":"146","author":"Kodde","year":"2007","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"10.1016\/j.bbadis.2016.08.019_bb0275","article-title":"Huntington's disease is a multi-system disorder","volume":"3","author":"Mielcarek","year":"2015","journal-title":"Rare Dis."},{"key":"10.1016\/j.bbadis.2016.08.019_bb0280","doi-asserted-by":"crossref","first-page":"5634","DOI":"10.1021\/pr400587y","article-title":"Metabonomic profiling revealed an alteration in purine nucleotide metabolism associated with cardiac hypertrophy in rats treated with thiazolidinediones","volume":"12","author":"Liu","year":"2013","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.bbadis.2016.08.019_bb0285","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.ydbio.2014.04.005","article-title":"Huntingtin protein is essential for mitochondrial metabolism, bioenergetics and structure in murine embryonic stem cells","volume":"391","author":"Ismailoglu","year":"2014","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bbadis.2016.08.019_bb0290","doi-asserted-by":"crossref","DOI":"10.1080\/15257770.2016.1154969","article-title":"Changes in cardiac nucleotide metabolism in Huntington's disease","author":"Toczek","year":"2016","journal-title":"Nucleosides Nucleotides Nucleic Acids"},{"key":"10.1016\/j.bbadis.2016.08.019_bb0295","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.pharmthera.2013.06.002","article-title":"Cardiovascular adenosine receptors: expression, actions and interactions","volume":"140","author":"Headrick","year":"2013","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bbadis.2016.08.019_bb0300","doi-asserted-by":"crossref","first-page":"I246","DOI":"10.1161\/hc37t1.094712","article-title":"Protection from reperfusion injury after cardiac transplantation by inhibition of adenosine metabolism and nucleotide precursor supply","volume":"104","author":"Smolenski","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.bbadis.2016.08.019_bb0305","doi-asserted-by":"crossref","first-page":"15259","DOI":"10.3390\/ijms150915259","article-title":"The adenosine deaminase gene polymorphism is associated with chronic heart failure risk in Chinese","volume":"15","author":"He","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2016.08.019_bb0310","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.lfs.2007.12.003","article-title":"E-NTPDases and ecto-5\u2032-nucleotidase expression profile in rat heart left ventricle and the extracellular nucleotide hydrolysis by their nerve terminal endings","volume":"82","author":"Rucker","year":"2008","journal-title":"Life Sci."},{"key":"10.1016\/j.bbadis.2016.08.019_bb0315","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1161\/01.RES.0000264058.28808.cc","article-title":"Regulation of cardiac cAMP synthesis and contractility by nucleoside diphosphate kinase B\/G protein beta gamma dimer complexes","volume":"100","author":"Hippe","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbadis.2016.08.019_bb0320","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0000647","article-title":"Early energy deficit in Huntington disease: identification of a plasma biomarker traceable during disease progression","volume":"2","author":"Mochel","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2016.08.019_bb0325","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1002\/mds.25992","article-title":"Metabolism in HD: still a relevant mechanism?","volume":"29","author":"Duan","year":"2014","journal-title":"Mov. Disord."},{"key":"10.1016\/j.bbadis.2016.08.019_bb0330","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nm.4003","article-title":"PPAR-delta is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically","volume":"22","author":"Dickey","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbadis.2016.08.019_bb0335","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1006\/jmcc.1997.0635","article-title":"Adenine\/ribose supply increases adenosine production and protects ATP pool in adenosine kinase-inhibited cardiac cells","volume":"30","author":"Smolenski","year":"1998","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbadis.2016.08.019_bb0340","doi-asserted-by":"crossref","first-page":"I246","DOI":"10.1161\/hc37t1.094712","article-title":"Protection from reperfusion injury after cardiac transplantation by inhibition of adenosine metabolism and nucleotide precursor supply","volume":"104","author":"Smolenski","year":"2001","journal-title":"Circulation"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443916302162?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443916302162?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T19:39:11Z","timestamp":1565379551000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443916302162"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":68,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["S0925443916302162"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2016.08.019","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An impaired metabolism of nucleotides underpins a novel mechanism of cardiac remodeling leading to Huntington's disease related cardiomyopathy","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2016.08.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V.","name":"copyright","label":"Copyright"}]}}