{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:44:41Z","timestamp":1790318681039,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"publisher","award":["31470912"],"award-info":[{"award-number":["31470912"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hong Kong Research Grant Committee","award":["TBRS\/T13-706\/11"],"award-info":[{"award-number":["TBRS\/T13-706\/11"]}]},{"name":"Hong Kong Research Grant Committee","award":["TBRS\/T12-705"],"award-info":[{"award-number":["TBRS\/T12-705"]}]},{"name":"Hong Kong Research Grant Committee","award":["AoE\/M-05\/12"],"award-info":[{"award-number":["AoE\/M-05\/12"]}]},{"name":"Hong Kong Research Grant Committee","award":["14118516"],"award-info":[{"award-number":["14118516"]}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2014CB965102"],"award-info":[{"award-number":["2014CB965102"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"RGC-NSFC Joint Grant","award":["N_CUHK439\/13"],"award-info":[{"award-number":["N_CUHK439\/13"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.bbadis.2017.07.021","type":"journal-article","created":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T22:31:23Z","timestamp":1501021883000},"page":"2964-2972","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["An abnormal TRPV4-related cytosolic Ca2+ rise in response to uniaxial stretch in induced pluripotent stem cells-derived cardiomyocytes from dilated cardiomyopathy patients"],"prefix":"10.1016","volume":"1863","author":[{"given":"Jun","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yee-Ki","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinru","family":"Ran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2102-7400","authenticated-orcid":false,"given":"Wing-Hon","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald A.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Keung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kennis","family":"Tse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung-Fat","family":"Tse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqiang","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2017.07.021_bb0005","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1161\/CIRCULATIONAHA.106.174287","volume":"113","author":"Maron","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.bbadis.2017.07.021_bb0010","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1016\/j.jacc.2011.01.015","article-title":"Update 2011: clinical and genetic issues in familial dilated cardiomyopathy","volume":"57","author":"Hershberger","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.bbadis.2017.07.021_bb0015","first-page":"637","article-title":"Sense and stretchability: the role of titin and titin-associated proteins in myocardial stress-sensing and mechanical dysfunction","volume":"77","author":"Linke","year":"2008","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbadis.2017.07.021_bb0020","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S0092-8674(00)80043-4","article-title":"Stress pathways and heart failure","volume":"98","author":"Chien","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2017.07.021_bb0025","doi-asserted-by":"crossref","first-page":"38505","DOI":"10.1074\/jbc.M505223200","article-title":"Ca2+ dysregulation induces mitochondrial depolarization and apoptosis: role of Na+\/Ca2+ exchanger and AKT","volume":"280","author":"Miyamoto","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2017.07.021_bb0030","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1126\/science.1081578","article-title":"Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban","volume":"299","author":"Schmitt","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2017.07.021_bb0035","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1161\/CIRCRESAHA.106.146670","article-title":"Knock-in mouse model of dilated cardiomyopathy caused by troponin mutation","volume":"101","author":"Du","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbadis.2017.07.021_bb0040","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/j.bbrc.2004.07.164","article-title":"Sarcoplasmic reticulum Ca-ATPase-phospholamban interactions and dilated cardiomyopathy","volume":"322","author":"Haghighi","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbadis.2017.07.021_bb0045","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1161\/CIRCRESAHA.107.156380","article-title":"Dilated and hypertrophic cardiomyopathy mutations in troponin and alpha-tropomyosin have opposing effects on the calcium affinity of cardiac thin filaments","volume":"101","author":"Robinson","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbadis.2017.07.021_bb0050","doi-asserted-by":"crossref","first-page":"130ra147","DOI":"10.1126\/scitranslmed.3003552","article-title":"Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy","volume":"4","author":"Sun","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.bbadis.2017.07.021_bb0055","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1093\/hmg\/ddv468","article-title":"Modeling structural and functional deficiencies of RBM20 familial dilated cardiomyopathy using human induced pluripotent stem cells","volume":"25","author":"Wyles","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbadis.2017.07.021_bb0060","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/483163a","article-title":"Cell biology: the sensation of stretch","volume":"483","author":"Gottlieb","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2017.07.021_bb0065","first-page":"6550","article-title":"Mechanosensitive ion channels in cardiovascular physiology","volume":"20","author":"Teng","year":"2014","journal-title":"Exp. Clin. Cardiol."},{"key":"10.1016\/j.bbadis.2017.07.021_bb0070","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1093\/cvr\/cvt163","article-title":"Blockade of sarcolemmal TRPV2 accumulation inhibits progression of dilated cardiomyopathy","volume":"99","author":"Iwata","year":"2013","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbadis.2017.07.021_bb0075","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1093\/hmg\/dds556","article-title":"Patient-specific induced-pluripotent stem cells-derived cardiomyocytes recapitulate the pathogenic phenotypes of dilated cardiomyopathy due to a novel DES mutation identified by whole exome sequencing","volume":"22","author":"Tse","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbadis.2017.07.021_bb0080","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1172\/JCI38027","article-title":"Tragedy in a heartbeat: malfunctioning desmin causes skeletal and cardiac muscle disease","volume":"119","author":"Goldfarb","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2017.07.021_bb0085","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1161\/01.CIR.100.5.461","article-title":"Desmin mutation responsible for idiopathic dilated cardiomyopathy","volume":"100","author":"Li","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.bbadis.2017.07.021_bb0090","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.nmd.2011.10.019","article-title":"High cardiovascular morbidity and mortality in myofibrillar myopathies due to DES gene mutations: a 10-year longitudinal study","volume":"22","author":"Wahbi","year":"2012","journal-title":"Neuromuscul. Disord."},{"key":"10.1016\/j.bbadis.2017.07.021_bb0095","doi-asserted-by":"crossref","first-page":"21257","DOI":"10.1074\/jbc.M109.020206","article-title":"The TRPV4 cation channel mediates stretch-evoked Ca2+ influx and ATP release in primary urothelial cell cultures","volume":"284","author":"Mochizuki","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2017.07.021_bb0100","doi-asserted-by":"crossref","first-page":"3471","DOI":"10.1113\/jphysiol.2011.207829","article-title":"Transient receptor potential vanilloid 4 (TRPV4)-dependent calcium influx and ATP release in mouse oesophageal keratinocytes","volume":"589","author":"Mihara","year":"2011","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbadis.2017.07.021_bb0105","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.yjmcc.2015.08.005","article-title":"Uniaxial cyclic stretch stimulates TRPV4 to induce realignment of human embryonic stem cell-derived cardiomyocytes","volume":"87","author":"Qi","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbadis.2017.07.021_bb0110","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","article-title":"Induction of pluripotent stem cells from adult human fibroblasts by defined factors","volume":"131","author":"Takahashi","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2017.07.021_bb0115","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.ijcard.2015.11.101","article-title":"Efficient attenuation of Friedreich's ataxia (FRDA) cardiomyopathy by modulation of iron homeostasis-human induced pluripotent stem cell (hiPSC) as a drug screening platform for FRDA","volume":"203","author":"Lee","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.bbadis.2017.07.021_bb0120","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1161\/CIRCRESAHA.108.188748","article-title":"TRPC1 associates with BK(Ca) channel to form a signal complex in vascular smooth muscle cells","volume":"104","author":"Kwan","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbadis.2017.07.021_bb0125","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1097\/FJC.0b013e318279ba42","article-title":"TRPV4 and the regulation of vascular tone","volume":"61","author":"Filosa","year":"2013","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.bbadis.2017.07.021_bb0130","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/nature01807","article-title":"Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels","volume":"424","author":"Watanabe","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2017.07.021_bb0135","doi-asserted-by":"crossref","first-page":"5400","DOI":"10.1073\/pnas.0808793106","article-title":"Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound","volume":"106","author":"Kiyonaka","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2017.07.021_bb0140","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1124\/mol.114.093229","article-title":"Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5","volume":"86","author":"Richter","year":"2014","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bbadis.2017.07.021_bb0145","doi-asserted-by":"crossref","first-page":"3650","DOI":"10.1111\/bph.13151","article-title":"Discovery and pharmacological characterization of a novel potent inhibitor of diacylglycerol-sensitive TRPC cation channels","volume":"172","author":"Maier","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbadis.2017.07.021_bb0150","doi-asserted-by":"crossref","first-page":"17165","DOI":"10.1074\/jbc.M313328200","article-title":"Identification of species-specific determinants of the action of the antagonist capsazepine and the agonist PPAHV on TRPV1","volume":"279","author":"Phillips","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2017.07.021_bb0155","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1096\/fj.03-0319fje","article-title":"Gating of the polycystin ion channel signaling complex in neurons and kidney cells","volume":"18","author":"Delmas","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.bbadis.2017.07.021_bb0160","doi-asserted-by":"crossref","first-page":"G235","DOI":"10.1152\/ajpgi.00256.2012","article-title":"TRPV2 ion channels expressed in inhibitory motor neurons of gastric myenteric plexus contribute to gastric adaptive relaxation and gastric emptying in mice","volume":"304","author":"Mihara","year":"2013","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.bbadis.2017.07.021_bb0165","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1039\/c0ib00034e","article-title":"Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface beta1 integrins","volume":"2","author":"Matthews","year":"2010","journal-title":"Integr. Biol. (Camb.)"},{"key":"10.1016\/j.bbadis.2017.07.021_bb0170","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1096\/fj.201600686RR","article-title":"Transient receptor potential vanilloid 2 activation by focal mechanical stimulation requires interaction with the actin cytoskeleton and enhances growth cone motility","volume":"31","author":"Sugio","year":"2017","journal-title":"FASEB J."},{"key":"10.1016\/j.bbadis.2017.07.021_bb0175","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1165\/rcmb.2009-0073OC","article-title":"Actin cytoskeleton regulates stretch-activated Ca2+ influx in human pulmonary microvascular endothelial cells","volume":"43","author":"Ito","year":"2010","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.bbadis.2017.07.021_bb0180","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1006\/bbrc.1999.1057","article-title":"Regulation of stretch-activated intracellular calcium transients by actin filaments","volume":"261","author":"Wu","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbadis.2017.07.021_bb0185","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/293302a0","article-title":"Cytochalasin D inhibits actin polymerization and induces depolymerization of actin filaments formed during platelet shape change","volume":"293","author":"Casella","year":"1981","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2017.07.021_bb0190","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1161\/CIRCRESAHA.109.204388","article-title":"Effects of mechanical stress and carvedilol in lamin A\/C-deficient dilated cardiomyopathy","volume":"106","author":"Chandar","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbadis.2017.07.021_bb0195","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1172\/JCI200419448","article-title":"Defects in nuclear structure and function promote dilated cardiomyopathy in lamin A\/C-deficient mice","volume":"113","author":"Nikolova","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2017.07.021_bb0200","doi-asserted-by":"crossref","first-page":"H1302","DOI":"10.1152\/ajpheart.00004.2013","article-title":"Modulation of stretch-induced myocyte remodeling and gene expression by nitric oxide: a novel role for lipoma preferred partner in myofibrillogenesis","volume":"304","author":"Hooper","year":"2013","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bbadis.2017.07.021_bb0205","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1042\/CS20080163","article-title":"Cellular and molecular effects of mechanical stretch on vascular cells and cardiac myocytes","volume":"116","author":"Shyu","year":"2009","journal-title":"Clin. Sci."},{"key":"10.1016\/j.bbadis.2017.07.021_bb0210","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1161\/CIRCULATIONAHA.109.935296","article-title":"Ca2+\/calmodulin-dependent kinase IIdelta causes heart failure by accumulation of p53 in dilated cardiomyopathy","volume":"122","author":"Toko","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.bbadis.2017.07.021_bb0215","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1113\/jphysiol.2002.027573","article-title":"Streptomycin and intracellular calcium modulate the response of single guinea-pig ventricular myocytes to axial stretch","volume":"546","author":"Belus","year":"2003","journal-title":"J. Physiol."},{"issue":"Pt 3","key":"10.1016\/j.bbadis.2017.07.021_bb0220","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1113\/jphysiol.1996.sp021243","article-title":"Changes in [Ca2+]i, [Na+]i and Ca2+ current in isolated rat ventricular myocytes following an increase in cell length","volume":"491","author":"Hongo","year":"1996","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbadis.2017.07.021_bb0225","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1007\/s00424-003-1018-y","article-title":"Ion selectivity of stretch-activated cation currents in mouse ventricular myocytes","volume":"446","author":"Kamkin","year":"2003","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.bbadis.2017.07.021_bb0230","doi-asserted-by":"crossref","first-page":"39786","DOI":"10.1074\/jbc.M506064200","article-title":"Role of endogenous TRPC6 channels in Ca2+ signal generation in A7r5 smooth muscle cells","volume":"280","author":"Soboloff","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2017.07.021_bb0235","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/415198a","article-title":"Cardiac excitation-contraction coupling","volume":"415","author":"Bers","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2017.07.021_bb0240","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.bbamem.2013.07.011","article-title":"The physiological role of cardiac cytoskeleton and its alterations in heart failure","volume":"1838","author":"Sequeira","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2017.07.021_bb0245","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0011654","article-title":"Importance of non-selective cation channel TRPV4 interaction with cytoskeleton and their reciprocal regulations in cultured cells","volume":"5","author":"Goswami","year":"2010","journal-title":"PLoS One"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443917302533?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443917302533?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T04:43:49Z","timestamp":1760417029000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443917302533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":49,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["S0925443917302533"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2017.07.021","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An abnormal TRPV4-related cytosolic Ca2+ rise in response to uniaxial stretch in induced pluripotent stem cells-derived cardiomyocytes from dilated cardiomyopathy patients","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2017.07.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V.","name":"copyright","label":"Copyright"}]}}