{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T12:51:14Z","timestamp":1768740674945,"version":"3.49.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81522005"],"award-info":[{"award-number":["81522005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31430041"],"award-info":[{"award-number":["31430041"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470522"],"award-info":[{"award-number":["81470522"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81230005"],"award-info":[{"award-number":["81230005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Qingdao Postdoctoral Application Research Project","award":["2015147"],"award-info":[{"award-number":["2015147"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.bbadis.2017.07.034","type":"journal-article","created":{"date-parts":[[2017,8,4]],"date-time":"2017-08-04T15:45:44Z","timestamp":1501861544000},"page":"2871-2881","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"title":["MiR-485-5p modulates mitochondrial fission through targeting mitochondrial anchored protein ligase in cardiac hypertrophy"],"prefix":"10.1016","volume":"1863","author":[{"given":"Yanfang","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murugavel","family":"Ponnusamy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuiyun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanhan","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinning","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaoqun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peifeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2017.07.034_bb0005","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/j.ijcard.2012.09.082","article-title":"Mitochondrial function in cardiac hypertrophy","volume":"167","author":"Zhou","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.bbadis.2017.07.034_bb0010","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1016\/j.cellsig.2015.06.009","article-title":"The alpha1-adrenergic receptors in cardiac hypertrophy: signaling mechanisms and functional implications","volume":"27","author":"Cotecchia","year":"2015","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbadis.2017.07.034_bb0015","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.yjmcc.2012.09.002","article-title":"Mitochondria in cardiac hypertrophy and heart failure","volume":"55","author":"Rosca","year":"2013","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbadis.2017.07.034_bb0020","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.ijcard.2016.04.007","article-title":"Candesartan cilexetil attenuated cardiac remodeling by improving expression and function of mitofusin 2 in SHR","volume":"214","author":"Wang","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.bbadis.2017.07.034_bb0025","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1146\/annurev.genet.38.072902.093019","article-title":"Mitochondrial morphology and dynamics in yeast and multicellular eukaryotes","volume":"39","author":"Okamoto","year":"2005","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.bbadis.2017.07.034_bb0030","doi-asserted-by":"crossref","first-page":"101","DOI":"10.4068\/cmj.2013.49.3.101","article-title":"Mitochondrial dynamics in the heart as a novel therapeutic target for cardioprotection","volume":"49","author":"Hwang","year":"2013","journal-title":"Chonnam Med. J."},{"key":"10.1016\/j.bbadis.2017.07.034_bb0035","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1253\/circj.CJ-14-0240","article-title":"Regulation of mitochondrial dynamics and cell fate","volume":"78","author":"Dhingra","year":"2014","journal-title":"Circ J"},{"key":"10.1016\/j.bbadis.2017.07.034_bb0040","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1111\/bph.12516","article-title":"Mitochondrial fusion and fission proteins: novel therapeutic targets for combating cardiovascular disease","volume":"171","author":"Hall","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbadis.2017.07.034_bb0045","article-title":"Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates the organelle's dynamics and signaling","volume":"3","author":"Li","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2017.07.034_bb0050","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.cub.2007.12.038","article-title":"Cargo-selected transport from the mitochondria to peroxisomes is mediated by vesicular carriers","volume":"18","author":"Neuspiel","year":"2008","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bbadis.2017.07.034_bb0055","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.cmet.2012.10.005","article-title":"The ubiquitin ligase Mul1 induces mitophagy in skeletal muscle in response to muscle-wasting stimuli","volume":"16","author":"Lokireddy","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbadis.2017.07.034_bb0060","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.01958","article-title":"MUL1 acts in parallel to the PINK1\/parkin pathway in regulating mitofusin and compensates for loss of PINK1\/parkin","volume":"3","author":"Yun","year":"2014","journal-title":"elife"},{"key":"10.1016\/j.bbadis.2017.07.034_bb0065","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1016\/j.cellsig.2014.09.004","article-title":"Mulan E3 ubiquitin ligase interacts with multiple E2 conjugating enzymes and participates in mitophagy by recruiting GABARAP","volume":"26","author":"Ambivero","year":"2014","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbadis.2017.07.034_bb0070","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/embor.2009.86","article-title":"MAPL is a new mitochondrial SUMO E3 ligase that regulates mitochondrial fission","volume":"10","author":"Braschi","year":"2009","journal-title":"EMBO Rep."},{"key":"10.1016\/j.bbadis.2017.07.034_bb0075","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1083\/jcb.200610042","article-title":"Bax\/Bak promote sumoylation of DRP1 and its stable association with mitochondria during apoptotic cell death","volume":"177","author":"Wasiak","year":"2007","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbadis.2017.07.034_bb0080","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1016\/j.celrep.2015.08.001","article-title":"VPS35 deficiency or mutation causes dopaminergic neuronal loss by impairing mitochondrial fusion and function","volume":"12","author":"Tang","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbadis.2017.07.034_bb0085","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.mito.2016.03.007","article-title":"Mitochondrial E3 ubiquitin ligase 1: a key enzyme in regulation of mitochondrial dynamics and functions","volume":"28","author":"Peng","year":"2016","journal-title":"Mitochondrion"},{"key":"10.1016\/j.bbadis.2017.07.034_bb0090","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1038\/cr.2008.75","article-title":"GIDE is a mitochondrial E3 ubiquitin ligase that induces apoptosis and slows growth","volume":"18","author":"Zhang","year":"2008","journal-title":"Cell Res."},{"key":"10.1016\/j.bbadis.2017.07.034_bb0095","doi-asserted-by":"crossref","first-page":"33382","DOI":"10.18632\/oncotarget.5407","article-title":"Non-thermal plasma induces AKT degradation through turn-on the MUL1 E3 ligase in head and neck cancer","volume":"6","author":"Kim","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbadis.2017.07.034_bb0100","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nature01957","article-title":"The nuclear RNase III Drosha initiates microRNA processing","volume":"425","author":"Lee","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2017.07.034_bb0105","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/4050116d-8daa-4b5a-99e9-34cdd13f6a26","article-title":"miR-30 regulates mitochondrial fission through targeting p53 and the dynamin-related protein-1 pathway","volume":"6","author":"Li","year":"2010","journal-title":"PLoS Genet."},{"key":"10.1016\/j.bbadis.2017.07.034_bb0110","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/nm.2282","article-title":"miR-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1","volume":"17","author":"Wang","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbadis.2017.07.034_bb0115","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.freeradbiomed.2013.07.009","article-title":"miR-761 regulates the mitochondrial network by targeting mitochondrial fission factor","volume":"65","author":"Long","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2017.07.034_bb0120","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2014.73","article-title":"miR-27 regulates mitochondrial networks by directly targeting the mitochondrial fission factor","volume":"46","author":"Tak","year":"2014","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.bbadis.2017.07.034_bb0125","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms1770","article-title":"miR-484 regulates mitochondrial network through targeting Fis1","volume":"3","author":"Wang","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbadis.2017.07.034_bb0130","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1038\/cdd.2014.200","article-title":"miR-361-regulated prohibitin inhibits mitochondrial fission and apoptosis and protects heart from ischemia injury","volume":"22","author":"Wang","year":"2015","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbadis.2017.07.034_bb0135","doi-asserted-by":"crossref","first-page":"7619","DOI":"10.1038\/ncomms8619","article-title":"E2F1-dependent miR-421 regulates mitochondrial fragmentation and myocardial infarction by targeting Pink1","volume":"6","author":"Wang","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbadis.2017.07.034_bb0140","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1128\/MCB.00774-13","article-title":"Mitofusin 1 is negatively regulated by microRNA 140 in cardiomyocyte apoptosis","volume":"34","author":"Li","year":"2014","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbadis.2017.07.034_bb0145","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2015.41","article-title":"MicroRNA-532-3p regulates mitochondrial fission through targeting apoptosis repressor with caspase recruitment domain in doxorubicin cardiotoxicity","volume":"6","author":"Wang","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbadis.2017.07.034_bb0150","doi-asserted-by":"crossref","first-page":"75","DOI":"10.2337\/db13-0340","article-title":"Insulin stimulates mitochondrial fusion and function in cardiomyocytes via the Akt-mTOR-NFkappaB-Opa-1 signaling pathway","volume":"63","author":"Parra","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2017.07.034_bb0155","first-page":"2659","article-title":"Mitochondrial fission is required for cardiomyocyte hypertrophy mediated by a Ca2+-calcineurin signaling pathway","volume":"127","author":"Pennanen","year":"2014","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbadis.2017.07.034_bb0160","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1074\/jbc.M111.266940","article-title":"Cardiac hypertrophy is positively regulated by MicroRNA miR-23a","volume":"287","author":"Wang","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2017.07.034_bb0165","doi-asserted-by":"crossref","first-page":"R551","DOI":"10.1016\/j.cub.2006.06.054","article-title":"Mitochondria: more than just a powerhouse","volume":"16","author":"McBride","year":"2006","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bbadis.2017.07.034_bb0170","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s00395-010-0122-3","article-title":"Expression of mitochondrial fusion-fission proteins during post-infarction remodeling: the effect of NHE-1 inhibition","volume":"106","author":"Javadov","year":"2011","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.bbadis.2017.07.034_bb0175","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1161\/CIRCULATIONAHA.115.020502","article-title":"Drp1-dependent mitochondrial autophagy plays a protective role against pressure overload-induced mitochondrial dysfunction and heart failure","volume":"133","author":"Shirakabe","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.bbadis.2017.07.034_bb0180","doi-asserted-by":"crossref","first-page":"13189","DOI":"10.1038\/ncomms13189","article-title":"CaMKII induces permeability transition through Drp1 phosphorylation during chronic beta-AR stimulation","volume":"7","author":"Xu","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbadis.2017.07.034_bb0185","doi-asserted-by":"crossref","first-page":"3094","DOI":"10.1074\/mcp.M113.027649","article-title":"Quantitative phosphoproteomic study of pressure-overloaded mouse heart reveals dynamin-related protein 1 as a modulator of cardiac hypertrophy","volume":"12","author":"Chang","year":"2013","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.bbadis.2017.07.034_bb0190","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.yjmcc.2016.08.016","article-title":"miR-106a promotes cardiac hypertrophy by targeting mitofusin 2","volume":"99","author":"Guan","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbadis.2017.07.034_bb0195","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ijcard.2014.10.122","article-title":"Mitofusin 2 ameliorates aortic remodeling by suppressing ras\/raf\/ERK pathway and regulating mitochondrial function in vascular smooth muscle cells","volume":"178","author":"Wang","year":"2015","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.bbadis.2017.07.034_bb0200","doi-asserted-by":"crossref","DOI":"10.1126\/science.aad0116","article-title":"Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice","volume":"350","author":"Wai","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2017.07.034_bb0205","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.bbagrm.2010.07.005","article-title":"Ubiquitin-proteasome system and mitochondria - reciprocity","volume":"1809","author":"Livnat-Levanon","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2017.07.034_bb0210","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.cmet.2012.10.013","article-title":"The missing link: Mul1 signals mitophagy and muscle wasting","volume":"16","author":"Attaix","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbadis.2017.07.034_bb0215","doi-asserted-by":"crossref","first-page":"6779","DOI":"10.1038\/ncomms7779","article-title":"APF lncRNA regulates autophagy and myocardial infarction by targeting miR-188-3p","volume":"6","author":"Wang","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbadis.2017.07.034_bb0220","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1016\/j.biopha.2016.10.073","article-title":"MicroRNAs regulate mitochondrial apoptotic pathway in myocardial ischemia-reperfusion-injury","volume":"84","author":"Makhdoumi","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbadis.2017.07.034_bb0225","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.3892\/ijmm.2015.2302","article-title":"miR4855p inhibits bladder cancer metastasis by targeting HMGA2","volume":"36","author":"Chen","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.bbadis.2017.07.034_bb0230","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.bbrc.2016.04.043","article-title":"MiR-485 inhibits metastasis and EMT of lung adenocarcinoma by targeting Flot2","volume":"477","author":"Mou","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbadis.2017.07.034_bb0235","first-page":"12292","article-title":"MicroRNA-485-5p suppresses cell proliferation and invasion in hepatocellular carcinoma by targeting stanniocalcin 2","volume":"8","author":"Guo","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.bbadis.2017.07.034_bb0240","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.biopha.2015.04.008","article-title":"Involvement of miR-485-5p in hepatocellular carcinoma progression targeting EMMPRIN","volume":"72","author":"Sun","year":"2015","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbadis.2017.07.034_bb0245","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.27","article-title":"MiR-485-3p and miR-485-5p suppress breast cancer cell metastasis by inhibiting PGC-1alpha expression","volume":"7","author":"Lou","year":"2016","journal-title":"Cell Death Dis."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443917302697?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443917302697?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T04:42:40Z","timestamp":1760416960000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443917302697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":49,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["S0925443917302697"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2017.07.034","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MiR-485-5p modulates mitochondrial fission through targeting mitochondrial anchored protein ligase in cardiac hypertrophy","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2017.07.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V.","name":"copyright","label":"Copyright"}]}}