{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:23:28Z","timestamp":1790785408076,"version":"4.1.0"},"reference-count":91,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T00:00:00Z","timestamp":1554163200000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KFO 217"],"award-info":[{"award-number":["KFO 217"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 974"],"award-info":[{"award-number":["SFB 974"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.bbadis.2017.08.021","type":"journal-article","created":{"date-parts":[[2017,8,25]],"date-time":"2017-08-25T06:47:33Z","timestamp":1503643653000},"page":"1319-1325","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":118,"special_numbering":"PB","title":["Bile acid receptors in the biliary tree: TGR5 in physiology and disease"],"prefix":"10.1016","volume":"1864","author":[{"given":"Kathleen","family":"Deutschmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Reich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Klindt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carola","family":"Dr\u00f6ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Spomer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"H\u00e4ussinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Keitel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2017.08.021_bb0005","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1007\/s00018-008-7568-6","article-title":"Bile acids: chemistry, pathochemistry, biology, pathobiology, and therapeutics","volume":"65","author":"Hofmann","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0010","doi-asserted-by":"crossref","first-page":"10046","DOI":"10.1074\/jbc.273.16.10046","article-title":"The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver","volume":"273","author":"Gerloff","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0015","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1159\/000371864","article-title":"The cholangiocyte glycocalyx stabilizes the 'biliary HCO3 umbrella': an integrated line of defense against toxic bile acids","volume":"33","author":"Maillette de Buy Wenniger","year":"2015","journal-title":"Dig. Dis."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0020","first-page":"1237","article-title":"Mice with homozygous disruption of the mdr2 P-glycoprotein gene. A novel animal model for studies of nonsuppurative inflammatory cholangitis and hepatocarcinogenesis","volume":"145","author":"Mauad","year":"1994","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0025","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1515\/BC.2007.021","article-title":"Hydrophobic bile salts trigger ceramide formation through endosomal acidification","volume":"388","author":"Becker","year":"2007","journal-title":"Biol. Chem."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0030","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1053\/gast.2002.32976","article-title":"Taurolithocholic acid-3 sulfate induces CD95 trafficking and apoptosis in a c-Jun N-terminal kinase-dependent manner","volume":"122","author":"Graf","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbadis.2017.08.021_bb0035","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1053\/j.gastro.2005.09.023","article-title":"Bile salt-induced apoptosis involves NADPH oxidase isoform activation","volume":"129","author":"Reinehr","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbadis.2017.08.021_bb0040","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1053\/j.gastro.2004.08.056","article-title":"Involvement of the Src family kinase yes in bile salt-induced apoptosis","volume":"127","author":"Reinehr","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbadis.2017.08.021_bb0045","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1172\/JCI117579","article-title":"Increases of intracellular magnesium promote glycodeoxycholate-induced apoptosis in rat hepatocytes","volume":"94","author":"Patel","year":"1994","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0050","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1002\/hep.23810","article-title":"The biliary HCO(3)(\u2212) umbrella: a unifying hypothesis on pathogenetic and therapeutic aspects of fibrosing cholangiopathies","volume":"52","author":"Beuers","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.bbadis.2017.08.021_bb0055","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/MOG.0b013e328352aab2","article-title":"The biliary HCO(3)(\u2212) umbrella: experimental evidence revisited","volume":"28","author":"Beuers","year":"2012","journal-title":"Curr. Opin. Gastroenterol."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0060","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/hep.24691","article-title":"A biliary HCO3- umbrella constitutes a protective mechanism against bile acid-induced injury in human cholangiocytes","volume":"55","author":"Hohenester","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.bbadis.2017.08.021_bb0065","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1007\/s12016-014-8443-x","article-title":"TGR5: pathogenetic role and\/or therapeutic target in fibrosing cholangitis?","volume":"48","author":"Keitel","year":"2015","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.bbadis.2017.08.021_bb0070","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1159\/000450917","article-title":"Role of the G protein-coupled bile acid receptor TGR5 in liver damage","volume":"35","author":"Reich","year":"2017","journal-title":"Dig. Dis."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0075","series-title":"Hepatobiliary Transport in Health and Disease","first-page":"85","article-title":"Bile acid signaling in the liver and the biliary tree","author":"H\u00e4ussinger","year":"2012"},{"key":"10.1016\/j.bbadis.2017.08.021_bb0080","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1146\/annurev.physiol.68.033104.152158","article-title":"LXRS and FXR: the yin and yang of cholesterol and fat metabolism","volume":"68","author":"Kalaany","year":"2006","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0085","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1159\/000371670","article-title":"Bile acids as hormones: the FXR-FGF15\/19 pathway","volume":"33","author":"Kliewer","year":"2015","journal-title":"Dig. Dis."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0090","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1126\/science.284.5418.1362","article-title":"Identification of a nuclear receptor for bile acids","volume":"284","author":"Makishima","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2017.08.021_bb0095","doi-asserted-by":"crossref","first-page":"4719","DOI":"10.2741\/3563","article-title":"Master regulation of bile acid and xenobiotic metabolism via the FXR, PXR and CAR trio","volume":"14","author":"Modica","year":"2009","journal-title":"Front. Biosci. (Landmark Ed.)"},{"key":"10.1016\/j.bbadis.2017.08.021_bb0100","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1126\/science.284.5418.1365","article-title":"Bile acids: natural ligands for an orphan nuclear receptor","volume":"284","author":"Parks","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2017.08.021_bb0105","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S1097-2765(00)80348-2","article-title":"Endogenous bile acids are ligands for the nuclear receptor FXR\/BAR","volume":"3","author":"Wang","year":"1999","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbadis.2017.08.021_bb0110","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1053\/jhep.2003.50176","article-title":"The normal liver harbors the vitamin D nuclear receptor in nonparenchymal and biliary epithelial cells","volume":"37","author":"Gascon-Barre","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.bbadis.2017.08.021_bb0115","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1124\/dmd.108.025155","article-title":"Mechanism of vitamin D receptor inhibition of cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes","volume":"37","author":"Han","year":"2009","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0120","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1126\/science.1070477","article-title":"Vitamin D receptor as an intestinal bile acid sensor","volume":"296","author":"Makishima","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2017.08.021_bb0125","doi-asserted-by":"crossref","DOI":"10.1621\/nrs.08005","article-title":"Deciphering the nuclear bile acid receptor FXR paradigm","volume":"8","author":"Modica","year":"2010","journal-title":"Nucl. Recept. Signal."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0130","doi-asserted-by":"crossref","first-page":"5492","DOI":"10.1016\/j.febslet.2006.07.082","article-title":"Nuclear bile acid receptor FXR as pharmacological target: are we there yet?","volume":"580","author":"Modica","year":"2006","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0135","doi-asserted-by":"crossref","first-page":"4559","DOI":"10.1021\/jm049904b","article-title":"Bile acid derivatives as ligands of the farnesoid X receptor. Synthesis, evaluation, and structure-activity relationship of a series of body and side chain modified analogues of chenodeoxycholic acid","volume":"47","author":"Pellicciari","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0140","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1002\/hep.25919","article-title":"Liver X receptor beta and peroxisome proliferator-activated receptor delta regulate cholesterol transport in murine cholangiocytes","volume":"56","author":"Xia","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.bbadis.2017.08.021_bb0145","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1073\/pnas.051551698","article-title":"The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity","volume":"98","author":"Staudinger","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0150","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1073\/pnas.051014398","article-title":"An essential role for nuclear receptors SXR\/PXR in detoxification of cholestatic bile acids","volume":"98","author":"Xie","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0155","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/S0925-4439(02)00115-1","article-title":"Functional interaction of lithocholic acid conjugates with M3 muscarinic receptors on a human colon cancer cell line","volume":"1588","author":"Cheng","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2017.08.021_bb0160","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0014-2999(02)02690-0","article-title":"Selective interaction of bile acids with muscarinic receptors: a case of molecular mimicry","volume":"457","author":"Raufman","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0165","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1159\/000064347","article-title":"Deoxycholic acid conjugates are muscarinic cholinergic receptor antagonists","volume":"65","author":"Raufman","year":"2002","journal-title":"Pharmacology"},{"key":"10.1016\/j.bbadis.2017.08.021_bb0170","doi-asserted-by":"crossref","first-page":"e9689","DOI":"10.1371\/journal.pone.0009689","article-title":"Bile acid-induced arrhythmia is mediated by muscarinic M2 receptors in neonatal rat cardiomyocytes","volume":"5","author":"Sheikh Abdul Kadir","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2017.08.021_bb0175","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1172\/JCI119655","article-title":"Role and mechanisms of action of acetylcholine in the regulation of rat cholangiocyte secretory functions","volume":"100","author":"Alvaro","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0180","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1002\/hep.29076","article-title":"The role of S1PR2 in bile acid-induced cholangiocyte proliferation and cholestasis-induced liver injury in mice","volume":"65","author":"Wang","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.bbadis.2017.08.021_bb0185","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1194\/jlr.R069286","article-title":"The roles of bile acids and sphingosine-1-phosphate signaling in the hepatobiliary diseases","volume":"57","author":"Nagahashi","year":"2016","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0190","doi-asserted-by":"crossref","first-page":"30988","DOI":"10.1074\/jbc.M115.668277","article-title":"Taurocholate induces cyclooxygenase-2 expression via the sphingosine 1-phosphate receptor 2 in a human cholangiocarcinoma cell line","volume":"290","author":"Liu","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0195","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1002\/hep.27085","article-title":"Conjugated bile acids promote cholangiocarcinoma cell invasive growth through activation of sphingosine 1-phosphate receptor 2","volume":"60","author":"Liu","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.bbadis.2017.08.021_bb0200","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1159\/000324127","article-title":"TGR5 in the biliary tree","volume":"29","author":"Keitel","year":"2011","journal-title":"Dig. Dis."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0205","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.clinre.2012.03.008","article-title":"Perspective: TGR5 (Gpbar-1) in liver physiology and disease","volume":"36","author":"Keitel","year":"2012","journal-title":"Clin. Res. Hepatol. Gastroenterol."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0210","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/MOG.0b013e32835f3f14","article-title":"TGR5 in cholangiocytes","volume":"29","author":"Keitel","year":"2013","journal-title":"Curr. Opin. Gastroenterol."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0215","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1515\/bc.2010.077","article-title":"The membrane-bound bile acid receptor TGR5 (Gpbar-1) is localized in the primary cilium of cholangiocytes","volume":"391","author":"Keitel","year":"2010","journal-title":"Biol. Chem."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0220","doi-asserted-by":"crossref","first-page":"G1013","DOI":"10.1152\/ajpgi.00383.2012","article-title":"Ciliary subcellular localization of TGR5 determines the cholangiocyte functional response to bile acid signaling","volume":"304","author":"Masyuk","year":"2013","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0225","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1136\/gutjnl-2015-309458","article-title":"TGR5 is essential for bile acid-dependent cholangiocyte proliferation in vivo and in vitro","volume":"65","author":"Reich","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.bbadis.2017.08.021_bb0230","doi-asserted-by":"crossref","first-page":"9435","DOI":"10.1074\/jbc.M209706200","article-title":"A G protein-coupled receptor responsive to bile acids","volume":"278","author":"Kawamata","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0235","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/S0006-291X(02)02550-0","article-title":"Identification of membrane-type receptor for bile acids (M-BAR)","volume":"298","author":"Maruyama","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0240","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1021\/jm7015864","article-title":"Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies","volume":"51","author":"Sato","year":"2008","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0245","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/hep.24681","article-title":"Conjugated bile acids activate the sphingosine-1-phosphate receptor 2 in primary rodent hepatocytes","volume":"55","author":"Studer","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.bbadis.2017.08.021_bb0250","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1002\/glia.21049","article-title":"The bile acid receptor TGR5 (Gpbar-1) acts as a neurosteroid receptor in brain","volume":"58","author":"Keitel","year":"2010","journal-title":"Glia"},{"key":"10.1016\/j.bbadis.2017.08.021_bb0255","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.placenta.2013.06.302","article-title":"Effect of maternal cholestasis on TGR5 expression in human and rat placenta at term","volume":"34","author":"Keitel","year":"2013","journal-title":"Placenta"},{"key":"10.1016\/j.bbadis.2017.08.021_bb0260","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.bbrc.2008.04.171","article-title":"Expression and function of the bile acid receptor TGR5 in Kupffer cells","volume":"372","author":"Keitel","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0265","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/hep.21458","article-title":"The G-protein coupled bile salt receptor TGR5 is expressed in liver sinusoidal endothelial cells","volume":"45","author":"Keitel","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.bbadis.2017.08.021_bb0270","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1002\/hep.23032","article-title":"The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders","volume":"50","author":"Keitel","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.bbadis.2017.08.021_bb0275","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.1113\/jphysiol.2010.192146","article-title":"Hydrophobic bile salts inhibit gallbladder smooth muscle function via stimulation of GPBAR1 receptors and activation of KATP channels","volume":"588","author":"Lavoie","year":"2010","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0280","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1210\/me.2010-0460","article-title":"The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder filling","volume":"25","author":"Li","year":"2011","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0285","doi-asserted-by":"crossref","first-page":"7958","DOI":"10.1021\/jm901390p","article-title":"Discovery of 6alpha-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity","volume":"52","author":"Pellicciari","year":"2009","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0290","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0136873","article-title":"Novel small molecule agonist of TGR5 possesses anti-diabetic effects but causes gallbladder filling in mice","volume":"10","author":"Briere","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2017.08.021_bb0295","doi-asserted-by":"crossref","first-page":"10475","DOI":"10.1021\/jm301071h","article-title":"Design, synthesis, and antidiabetic activity of 4-phenoxynicotinamide and 4-phenoxypyrimidine-5-carboxamide derivatives as potent and orally efficacious TGR5 agonists","volume":"55","author":"Duan","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0300","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1042\/BJ20060537","article-title":"Targeted deletion of Gpbar1 protects mice from cholesterol gallstone formation","volume":"398","author":"Vassileva","year":"2006","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0305","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1002\/hep.26463","article-title":"The receptor TGR5 protects the liver from bile acid overload during liver regeneration in mice","volume":"58","author":"Pean","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.bbadis.2017.08.021_bb0310","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1038\/ng.221","article-title":"Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility","volume":"40","author":"Franke","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0315","doi-asserted-by":"crossref","first-page":"e12403","DOI":"10.1371\/journal.pone.0012403","article-title":"Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis","volume":"5","author":"Hov","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2017.08.021_bb0320","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1159\/000324138","article-title":"TGR5 sequence variation in primary sclerosing cholangitis","volume":"29","author":"Hov","year":"2011","journal-title":"Dig. Dis."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0325","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1159\/000371696","article-title":"TGR5 in the Cholangiociliopathies","volume":"33","author":"Masyuk","year":"2015","journal-title":"Dig. Dis."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0330","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.cgh.2016.03.008","article-title":"Polycystic liver disease: the benefits of targeting cAMP","volume":"14","author":"Larusso","year":"2016","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0335","doi-asserted-by":"crossref","DOI":"10.1002\/hep.29284","article-title":"TGR5 contributes to hepatic cystogenesis in rodents with polycystic liver diseases via cAMP\/Galphas signaling","author":"Masyuk","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.bbadis.2017.08.021_bb0340","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1159\/000450989","article-title":"Bile acids in polycystic liver diseases: triggers of disease progression and potential solution for treatment","volume":"35","author":"Perugorria","year":"2017","journal-title":"Dig. Dis."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0345","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1158\/1541-7786.MCR-13-0503","article-title":"Cocarcinogenic effects of intrahepatic bile acid accumulation in cholangiocarcinoma development","volume":"12","author":"Lozano","year":"2014","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0350","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3109\/07357907.2012.762781","article-title":"Bile acids affect the growth of human cholangiocarcinoma via NF-kB pathway","volume":"31","author":"Dai","year":"2013","journal-title":"Cancer Investig."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0355","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1756-8722-4-41","article-title":"Impact of bile acids on the growth of human cholangiocarcinoma via FXR","volume":"4","author":"Dai","year":"2011","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0360","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1186\/1471-2407-10-302","article-title":"Expression of growth factor receptors and targeting of EGFR in cholangiocarcinoma cell lines","volume":"10","author":"Xu","year":"2010","journal-title":"BMC Cancer"},{"key":"10.1016\/j.bbadis.2017.08.021_bb0365","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.3892\/ijo.2015.2939","article-title":"Taurolithocholic acid promotes intrahepatic cholangiocarcinoma cell growth via muscarinic acetylcholine receptor and EGFR\/ERK1\/2 signaling pathway","volume":"46","author":"Amonyingcharoen","year":"2015","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0370","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1007\/s00424-013-1364-3","article-title":"FXR-induced secretion of FGF15\/19 inhibits CYP27 expression in cholangiocytes through p38 kinase pathway","volume":"466","author":"Jung","year":"2014","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0375","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.dld.2012.12.012","article-title":"Dysregulation of vitamin D3 synthesis leads to enhanced cholangiocarcinoma growth","volume":"45","author":"Kennedy","year":"2013","journal-title":"Dig. Liver Dis."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0380","doi-asserted-by":"crossref","first-page":"5424","DOI":"10.1172\/JCI76289","article-title":"TGR5 reduces macrophage migration through mTOR-induced C\/EBPbeta differential translation","volume":"124","author":"Perino","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0385","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.tips.2015.08.002","article-title":"TGR5 and immunometabolism: insights from physiology and pharmacology","volume":"36","author":"Perino","year":"2015","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0390","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.cmet.2011.11.006","article-title":"TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading","volume":"14","author":"Pols","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0395","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1002\/hep.24525","article-title":"The G-protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor kappa light-chain enhancer of activated B cells (NF-kappaB) in mice","volume":"54","author":"Wang","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.bbadis.2017.08.021_bb0400","doi-asserted-by":"crossref","first-page":"G322","DOI":"10.1152\/ajpgi.00263.2012","article-title":"Expression of bile acid receptor TGR5 in gastric adenocarcinoma","volume":"304","author":"Cao","year":"2013","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0405","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1136\/gut.2009.188375","article-title":"Role of a novel bile acid receptor TGR5 in the development of oesophageal adenocarcinoma","volume":"59","author":"Hong","year":"2010","journal-title":"Gut"},{"key":"10.1016\/j.bbadis.2017.08.021_bb0410","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.4161\/cc.21029","article-title":"Chenodeoxycholic acid through a TGR5-dependent CREB signaling activation enhances cyclin D1 expression and promotes human endometrial cancer cell proliferation","volume":"11","author":"Casaburi","year":"2012","journal-title":"Cell Cycle"},{"key":"10.1016\/j.bbadis.2017.08.021_bb0415","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1172\/JCI64551","article-title":"The TGR5 receptor mediates bile acid-induced itch and analgesia","volume":"123","author":"Alemi","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0420","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1002\/hep.23585","article-title":"Hypertrophic cardiomyopathy and dysregulation of cardiac energetics in a mouse model of biliary fibrosis","volume":"51","author":"Desai","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.bbadis.2017.08.021_bb0425","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1124\/jpet.113.210005","article-title":"G protein-coupled bile acid receptor 1 stimulation mediates arterial vasodilation through a K(Ca)1.1 (BK(Ca))-dependent mechanism","volume":"348","author":"Fryer","year":"2014","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0430","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nbt.3275","article-title":"Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation","volume":"33","author":"Sampaziotis","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0435","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/nm.4360","article-title":"Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids","volume":"23","author":"Sampaziotis","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0440","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/labinvest.2015.51","article-title":"Development and characterization of human-induced pluripotent stem cell-derived cholangiocytes","volume":"95","author":"De Assuncao","year":"2015","journal-title":"Lab. Investig."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0445","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.stemcr.2017.06.003","article-title":"Adult mouse liver contains two distinct populations of cholangiocytes","volume":"9","author":"Li","year":"2017","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0450","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/nbt.3294","article-title":"Directed differentiation of cholangiocytes from human pluripotent stem cells","volume":"33","author":"Ogawa","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.bbadis.2017.08.021_bb0455","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/mmi.12378","article-title":"Sphingosine kinase A is a pleiotropic and essential enzyme for Leishmania survival and virulence","volume":"90","author":"Zhang","year":"2013","journal-title":"Mol. Microbiol."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443917303034?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443917303034?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T04:41:16Z","timestamp":1760416876000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443917303034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":91,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["S0925443917303034"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2017.08.021","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bile acid receptors in the biliary tree: TGR5 in physiology and disease","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2017.08.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V.","name":"copyright","label":"Copyright"}]}}