{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:24:23Z","timestamp":1790630663039,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Italian Association for Cancer Research","doi-asserted-by":"publisher","award":["14191"],"award-info":[{"award-number":["14191"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","award":["243188"],"award-info":[{"award-number":["243188"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002749","name":"Belgian Science Policy Office","doi-asserted-by":"publisher","award":["UP7-03"],"award-info":[{"award-number":["UP7-03"]}],"id":[{"id":"10.13039\/501100002749","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Communaut\u00e9 Fran\u00e7aise de Belgique","award":["14\/19-058"],"award-info":[{"award-number":["14\/19-058"]}]},{"name":"Belgian Fonds National de la Recherche Scientifique","award":["2014\/V 6\/5\/006-LID-6394"],"award-info":[{"award-number":["2014\/V 6\/5\/006-LID-6394"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.bbadis.2017.08.030","type":"journal-article","created":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T15:45:37Z","timestamp":1504280737000},"page":"3254-3264","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":75,"title":["MDA-MB-231 breast cancer cells fuel osteoclast metabolism and activity: A new rationale for the pathogenesis of osteolytic bone metastases"],"prefix":"10.1016","volume":"1863","author":[{"given":"Silvia","family":"Lemma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Di Pompo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo E.","family":"Porporato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Sboarina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shonagh","family":"Russell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Gillies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Baldini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Sonveaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Avnet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2017.08.030_bb0005","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nrc3055","article-title":"Cancer to bone: a fatal attraction","volume":"11","author":"Weilbaecher","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbadis.2017.08.030_bb0010","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.molmed.2005.11.007","article-title":"RANKL-RANK signaling in osteoclastogenesis and bone disease","volume":"12","author":"Wada","year":"2006","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.bbadis.2017.08.030_bb0015","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature01658","article-title":"Osteoclast differentiation and activation","volume":"423","author":"Boyle","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2017.08.030_bb0020","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0002-9343(97)80047-2","article-title":"Hypercalcemia of malignancy","volume":"103","author":"Mundy","year":"1997","journal-title":"Am. J. Med."},{"key":"10.1016\/j.bbadis.2017.08.030_bb0025","doi-asserted-by":"crossref","first-page":"6243s","DOI":"10.1158\/1078-0432.CCR-06-0931","article-title":"Clinical features of metastatic bone disease and risk of skeletal morbidity","volume":"12","author":"Coleman","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbadis.2017.08.030_bb0030","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/nrc865","article-title":"Dissemination and growth of cancer cells in metastatic sites","volume":"2","author":"Chambers","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbadis.2017.08.030_bb0035","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.bbrc.2004.11.070","article-title":"Crosstalk between cancer cells and bone microenvironment in bone metastasis","volume":"328","author":"Yoneda","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbadis.2017.08.030_bb0040","doi-asserted-by":"crossref","first-page":"4157","DOI":"10.1158\/0008-5472.CAN-06-2355","article-title":"Hypoxia and hypoxia-inducible factor-1 expression enhance osteolytic bone metastases of breast cancer","volume":"67","author":"Hiraga","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbadis.2017.08.030_bb0045","first-page":"570","article-title":"The vicious cycle of bone metastases","volume":"2","author":"Guise","year":"2002","journal-title":"J. Musculoskelet. Neuronal Interact."},{"key":"10.1016\/j.bbadis.2017.08.030_bb0050","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1002\/ijc.26031","article-title":"The seed and soil hypothesis revisited\u2013the role of tumor-stroma interactions in metastasis to different organs","volume":"128","author":"Langley","year":"2011","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bbadis.2017.08.030_bb0055","first-page":"3059","article-title":"Localization of parathyroid hormone-related protein in breast cancer metastases: increased incidence in bone compared with other sites","volume":"51","author":"Powell","year":"1991","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbadis.2017.08.030_bb0060","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1084\/jem.191.2.275","article-title":"Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF\/RANKL-RANK interaction","volume":"191","author":"Kobayashi","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbadis.2017.08.030_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S8756-3282(02)00915-8","article-title":"Interleukin-6 and interleukin-11 support human osteoclast formation by a RANKL-independent mechanism","volume":"32","author":"Kudo","year":"2003","journal-title":"Bone"},{"key":"10.1016\/j.bbadis.2017.08.030_bb0070","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1016\/j.yexcr.2011.05.030","article-title":"IGF2 derived from SH-SY5Y neuroblastoma cells induces the osteoclastogenesis of human monocytic precursors","volume":"317","author":"Avnet","year":"2011","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbadis.2017.08.030_bb0075","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.bone.2003.08.008","article-title":"Transforming growth factor-beta induces osteoclast formation in the absence of RANKL","volume":"34","author":"Itonaga","year":"2004","journal-title":"Bone"},{"key":"10.1016\/j.bbadis.2017.08.030_bb0080","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1002\/ijc.20308","article-title":"In vitro blockade of receptor activator of nuclear factor-kappaB ligand prevents osteoclastogenesis induced by neuroblastoma cells","volume":"111","author":"Granchi","year":"2004","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bbadis.2017.08.030_bb0085","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1177\/1758834011412656","article-title":"Denosumab for the treatment of bone metastases in breast cancer: evidence and opinion","volume":"3","author":"Steger","year":"2011","journal-title":"Ther. Adv. Med. Oncol."},{"key":"10.1016\/j.bbadis.2017.08.030_bb0090","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1126\/science.1193494","article-title":"The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes","volume":"330","author":"Levine","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2017.08.030_bb0095","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1007\/s00018-015-2098-5","article-title":"Metabolic changes associated with tumor metastasis, part 1: tumor pH, glycolysis and the pentose phosphate pathway","volume":"73","author":"Payen","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bbadis.2017.08.030_bb0100","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/978-1-4615-0205-0_9","article-title":"Mechanisms underlying hypoxia development in tumors","volume":"510","author":"Dewhirst","year":"2003","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.bbadis.2017.08.030_bb0105","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1126\/science.123.3191.309","article-title":"On the origin of cancer cells","volume":"123","author":"Warburg","year":"1956","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2017.08.030_bb0110","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1038\/nrc1478","article-title":"Why do cancers have high aerobic glycolysis?","volume":"4","author":"Gatenby","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbadis.2017.08.030_bb0115","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.2174\/138161212799504902","article-title":"Multiple biological activities of lactic acid in cancer: influences on tumor growth, angiogenesis and metastasis","volume":"18","author":"Dhup","year":"2012","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bbadis.2017.08.030_bb0120","first-page":"916","article-title":"High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers","volume":"60","author":"Walenta","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbadis.2017.08.030_bb0125","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1158\/0008-5472.CAN-10-2828","article-title":"Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-kappaB\/IL-8 pathway that drives tumor angiogenesis","volume":"71","author":"Vegran","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbadis.2017.08.030_bb0130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0033418","article-title":"Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis","volume":"7","author":"Sonveaux","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2017.08.030_bb0135","doi-asserted-by":"crossref","first-page":"7575","DOI":"10.18632\/oncotarget.2243","article-title":"Role of mesenchymal stem cells in osteosarcoma and metabolic reprogramming of tumor cells","volume":"5","author":"Bonuccelli","year":"2014","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbadis.2017.08.030_bb0140","first-page":"3930","article-title":"Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice","volume":"118","author":"Sonveaux","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2017.08.030_bb0145","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.biocel.2016.08.034","article-title":"Energy metabolism in osteoclast formation and activity","volume":"79","author":"Lemma","year":"2016","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.bbadis.2017.08.030_bb0150","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1158\/1535-7163.MCT-13-0653","article-title":"Antitumor activity of 7-aminocarboxycoumarin derivatives, a new class of potent inhibitors of lactate influx but not efflux","volume":"13","author":"Draoui","year":"2014","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.bbadis.2017.08.030_bb0155","doi-asserted-by":"crossref","first-page":"21971","DOI":"10.1074\/jbc.M200434200","article-title":"Transcriptional program of mouse osteoclast differentiation governed by the macrophage colony-stimulating factor and the ligand for the receptor activator of NFkappa B","volume":"277","author":"Cappellen","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2017.08.030_bb0160","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0149481","article-title":"Identification and validation of housekeeping genes for gene expression analysis of cancer stem cells","volume":"11","author":"Lemma","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2017.08.030_bb0165","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.bbrc.2014.07.050","article-title":"Expression of the hypoxia-inducible monocarboxylate transporter MCT4 is increased in triple negative breast cancer and correlates independently with clinical outcome","volume":"451","author":"Doyen","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbadis.2017.08.030_bb0170","first-page":"3092","article-title":"A negative regulatory factor is missing in a human metastatic breast cancer cell line","volume":"54","author":"Stover","year":"1994","journal-title":"Cancer Res."},{"issue":"Pt 1","key":"10.1016\/j.bbadis.2017.08.030_bb0175","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1042\/bj3500219","article-title":"The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells","volume":"350","author":"Dimmer","year":"2000","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbadis.2017.08.030_bb0180","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1016\/j.bbamcr.2016.03.013","article-title":"Monocarboxylate transporters in the brain and in cancer","volume":"1863","author":"Perez-Escuredo","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2017.08.030_bb0185","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/S0360-3016(01)01700-X","article-title":"Tissue gradients of energy metabolites mirror oxygen tension gradients in a rat mammary carcinoma model","volume":"51","author":"Walenta","year":"2001","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.bbadis.2017.08.030_bb0190","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1593\/neo.07724","article-title":"Regulation of the Warburg effect in early-passage breast cancer cells","volume":"10","author":"Robey","year":"2008","journal-title":"Neoplasia"},{"key":"10.1016\/j.bbadis.2017.08.030_bb0195","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1593\/neo.04430","article-title":"Hypoxia-inducible factor-1alpha and the glycolytic phenotype in tumors","volume":"7","author":"Robey","year":"2005","journal-title":"Neoplasia"},{"issue":"Pt 2","key":"10.1016\/j.bbadis.2017.08.030_bb0200","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1042\/bj3430281","article-title":"The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation","volume":"343","author":"Halestrap","year":"1999","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbadis.2017.08.030_bb0205","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1152\/jappl.1998.84.3.987","article-title":"Training intensity-dependent and tissue-specific increases in lactate uptake and MCT-1 in heart and muscle","volume":"84","author":"Baker","year":"1998","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.bbadis.2017.08.030_bb0210","doi-asserted-by":"crossref","first-page":"9030","DOI":"10.1074\/jbc.M511397200","article-title":"The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism","volume":"281","author":"Ullah","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2017.08.030_bb0215","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1159\/000070297","article-title":"Reduced expression of GNA11 and silencing of MCT1 in human breast cancers","volume":"64","author":"Asada","year":"2003","journal-title":"Oncology"},{"key":"10.1016\/j.bbadis.2017.08.030_bb0220","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.yexcr.2011.11.014","article-title":"Lactate is a mediator of metabolic cooperation between stromal carcinoma associated fibroblasts and glycolytic tumor cells in the tumor microenvironment","volume":"318","author":"Rattigan","year":"2012","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbadis.2017.08.030_bb0225","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nature13034","article-title":"Direct measurement of local oxygen concentration in the bone marrow of live animals","volume":"508","author":"Spencer","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2017.08.030_bb0230","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1006\/bbrc.1997.6795","article-title":"Regulation of osteoclastic bone resorption by glucose","volume":"235","author":"Williams","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbadis.2017.08.030_bb0235","doi-asserted-by":"crossref","first-page":"2744","DOI":"10.4161\/cc.25825","article-title":"Regulation of lysosome biogenesis and functions in osteoclasts","volume":"12","author":"Lacombe","year":"2013","journal-title":"Cell Cycle"},{"key":"10.1016\/j.bbadis.2017.08.030_bb0240","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0153886","article-title":"Accelerated lactate dehydrogenase activity potentiates osteoclastogenesis via NFATc1 signaling","volume":"11","author":"Ahn","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2017.08.030_bb0245","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1158\/1535-7163.MCT-13-1091","article-title":"Inhibition of monocarboxylate transporter-1 (MCT1) by AZD3965 enhances radiosensitivity by reducing lactate transport","volume":"13","author":"Bola","year":"2014","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.bbadis.2017.08.030_bb0250","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1002\/jor.20209","article-title":"Effects of antisense mediated inhibition of cathepsin K on human osteoclasts obtained from peripheral blood","volume":"24","author":"Avnet","year":"2006","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bbadis.2017.08.030_bb0255","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.yexcr.2006.10.001","article-title":"RANK ligand signaling modulates the matrix metalloproteinase-9 gene expression during osteoclast differentiation","volume":"313","author":"Sundaram","year":"2007","journal-title":"Exp. Cell Res."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443917303125?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443917303125?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,30]],"date-time":"2018-11-30T21:08:49Z","timestamp":1543612129000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443917303125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":51,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["S0925443917303125"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2017.08.030","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MDA-MB-231 breast cancer cells fuel osteoclast metabolism and activity: A new rationale for the pathogenesis of osteolytic bone metastases","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2017.08.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V.","name":"copyright","label":"Copyright"}]}}