{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:33:00Z","timestamp":1787506380478,"version":"build-2736575974"},"reference-count":41,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T00:00:00Z","timestamp":1554163200000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["RU 1936\/1-2"],"award-info":[{"award-number":["RU 1936\/1-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.bbadis.2017.09.012","type":"journal-article","created":{"date-parts":[[2017,9,22]],"date-time":"2017-09-22T12:00:31Z","timestamp":1506081631000},"page":"1380-1389","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"PB","title":["Pathological features of primary sclerosing cholangitis identified by bile proteomic analysis"],"prefix":"10.1016","volume":"1864","author":[{"given":"C.","family":"Rupp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.A.","family":"Bode","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Leopold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Sauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.N.","family":"Gotthardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.bbadis.2017.09.012_bb0005","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1136\/gut.21.10.870","article-title":"Primary sclerosing cholangitis: a review of its clinical features, cholangiography, and hepatic histology","volume":"21","author":"Chapman","year":"1980","journal-title":"Gut"},{"issue":"12","key":"10.1016\/j.bbadis.2017.09.012_bb0010","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1056\/NEJMra1506330","article-title":"Primary Sclerosing Cholangitis","volume":"375","author":"Lazaridis","year":"2016","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.bbadis.2017.09.012_bb0015","first-page":"661","article-title":"Endoscopic therapy of sclerosing cholangitis","volume":"21","author":"Lee","year":"1995","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.bbadis.2017.09.012_bb0020","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.gie.2009.10.041","article-title":"Endoscopic dilation of dominant stenoses in primary sclerosing cholangitis: outcome after long-term treatment","volume":"71","author":"Gotthardt","year":"2010","journal-title":"Gastrointest. Endosc."},{"key":"10.1016\/j.bbadis.2017.09.012_bb0025","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2017.02.038","article-title":"Patient age, sex, and inflammatory bowel disease phenotype associate with course of primary sclerosing cholangitis","author":"Weismuller","year":"2017","journal-title":"Gastroenterology"},{"issue":"8","key":"10.1016\/j.bbadis.2017.09.012_bb0030","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/ng.627","article-title":"Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis","volume":"42","author":"Liu","year":"2010","journal-title":"Nat. Genet."},{"issue":"2","key":"10.1016\/j.bbadis.2017.09.012_bb0035","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.jhep.2012.03.031","article-title":"Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci","volume":"57","author":"Folseraas","year":"2012","journal-title":"J. Hepatol."},{"issue":"3","key":"10.1016\/j.bbadis.2017.09.012_bb0040","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1002\/hep.25977","article-title":"Genome-wide association analysis in primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4","volume":"58","author":"Ellinghaus","year":"2013","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.bbadis.2017.09.012_bb0045","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/hep.21294","article-title":"Proteomic profiling of cholangiocarcinoma: diagnostic potential of SELDI-TOF MS in malignant bile duct stricture","volume":"44","author":"Scarlett","year":"2006","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.bbadis.2017.09.012_bb0050","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S1470-2045(08)70027-5","article-title":"Circulating markers of biliary malignancy: opportunities in proteomics?","volume":"9","author":"Bonney","year":"2008","journal-title":"Lancet Oncol."},{"issue":"3","key":"10.1016\/j.bbadis.2017.09.012_bb0055","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1002\/hep.24103","article-title":"Bile proteomic profiles differentiate cholangiocarcinoma from primary sclerosing cholangitis and choledocholithiasis","volume":"53","author":"Lankisch","year":"2011","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.bbadis.2017.09.012_bb0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0029821","article-title":"S100A9 is a biliary protein marker of disease activity in primary sclerosing cholangitis","volume":"7","author":"Reinhard","year":"2012","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.bbadis.2017.09.012_bb0065","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/S0025-6196(11)64614-4","article-title":"A revised natural history model for primary sclerosing cholangitis","volume":"75","author":"Kim","year":"2000","journal-title":"Mayo Clin. Proc."},{"issue":"3","key":"10.1016\/j.bbadis.2017.09.012_bb0070","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1104\/pp.81.3.802","article-title":"Solubilization of plant membrane proteins for analysis by two-dimensional gel electrophoresis","volume":"81","author":"Hurkman","year":"1986","journal-title":"Plant Physiol."},{"issue":"6","key":"10.1016\/j.bbadis.2017.09.012_bb0075","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1002\/(SICI)1522-2683(20000401)21:6<1037::AID-ELPS1037>3.0.CO;2-V","article-title":"The current state of two-dimensional electrophoresis with immobilized pH gradients","volume":"21","author":"Gorg","year":"2000","journal-title":"Electrophoresis"},{"issue":"12","key":"10.1016\/j.bbadis.2017.09.012_bb0080","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1074\/mcp.M600113-MCP200","article-title":"Proteomics fingerprinting of phagosome maturation and evidence for the role of a Galpha during uptake","volume":"5","author":"Gotthardt","year":"2006","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.bbadis.2017.09.012_bb0085","doi-asserted-by":"crossref","first-page":"D142","DOI":"10.1093\/nar\/gkp846","volume":"38","author":"The Universal Protein Resource (UniProt) in 2010","year":"2010","journal-title":"Nucleic Acids Res."},{"issue":"7","key":"10.1016\/j.bbadis.2017.09.012_bb0090","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1074\/mcp.M400015-MCP200","article-title":"A proteomic analysis of human bile","volume":"3","author":"Kristiansen","year":"2004","journal-title":"Mol. Cell. Proteomics"},{"issue":"3","key":"10.1016\/j.bbadis.2017.09.012_bb0095","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1586\/epr.09.12","article-title":"Proteomic analysis of human bile and potential applications for cancer diagnosis","volume":"6","author":"Farina","year":"2009","journal-title":"Expert Rev Proteomics"},{"key":"10.1016\/j.bbadis.2017.09.012_bb0100","first-page":"248613","article-title":"Relative quantification of several plasma proteins during liver transplantation surgery","volume":"2011","author":"Parviainen","year":"2011","journal-title":"J Biomed Biotechnol"},{"issue":"12","key":"10.1016\/j.bbadis.2017.09.012_bb0105","doi-asserted-by":"crossref","first-page":"3642","DOI":"10.1007\/s10620-015-3805-7","article-title":"Individuals with Primary Sclerosing Cholangitis Have Elevated Levels of Biomarkers for Apoptosis but Not Necrosis","volume":"60","author":"Masuoka","year":"2015","journal-title":"Dig. Dis. Sci."},{"issue":"9","key":"10.1016\/j.bbadis.2017.09.012_bb0110","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1111\/liv.13092","article-title":"Elevated interleukin-8 in bile of patients with primary sclerosing cholangitis","volume":"36","author":"Zweers","year":"2016","journal-title":"Liver Int."},{"issue":"10","key":"10.1016\/j.bbadis.2017.09.012_bb0115","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1097\/MCG.0000000000000042","article-title":"Calprotectin in bile: a disease severity marker in patients with primary sclerosing cholangitis","volume":"48","author":"Voigtlander","year":"2014","journal-title":"J. Clin. Gastroenterol."},{"issue":"17","key":"10.1016\/j.bbadis.2017.09.012_bb0120","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000003510","article-title":"Evaluation of Biliary Calprotectin as a Biomarker in Primary Sclerosing Cholangitis","volume":"95","author":"Gauss","year":"2016","journal-title":"Medicine (Baltimore)"},{"issue":"2","key":"10.1016\/j.bbadis.2017.09.012_bb0125","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1002\/hep.26702","article-title":"CD8 T cells primed in the gut-associated lymphoid tissue induce immune-mediated cholangitis in mice","volume":"59","author":"Seidel","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.bbadis.2017.09.012_bb0130","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.0105-2896.2004.0131.x","article-title":"A Toll-like receptor in horseshoe crabs","volume":"198","author":"Inamori","year":"2004","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.bbadis.2017.09.012_bb0135","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.clim.2016.09.005","article-title":"Toll-like receptor-mediated immune responses in intestinal macrophages; implications for mucosal immunity and autoimmune diseases","volume":"173","author":"Zhou","year":"2016","journal-title":"Clin. Immunol."},{"issue":"2","key":"10.1016\/j.bbadis.2017.09.012_bb0140","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.4049\/jimmunol.166.2.1075","article-title":"Induction of a novel mechanism of accelerated bacterial clearance by lipopolysaccharide in CD14-deficient and Toll-like receptor 4-deficient mice","volume":"166","author":"Haziot","year":"2001","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.bbadis.2017.09.012_bb0145","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.cell.2011.09.051","article-title":"CD14 controls the LPS-induced endocytosis of Toll-like receptor 4","volume":"147","author":"Zanoni","year":"2011","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.bbadis.2017.09.012_bb0150","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1002\/hep.28543","article-title":"CD14 is associated with biliary stricture formation","volume":"64","author":"Friedrich","year":"2016","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.bbadis.2017.09.012_bb0155","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1182\/blood-2009-06-226944","article-title":"Annexin A2 tetramer activates human and murine macrophages through TLR4","volume":"115","author":"Swisher","year":"2010","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.bbadis.2017.09.012_bb0160","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/j.jhep.2017.01.019","article-title":"Novel serum and bile protein markers predict primary sclerosing cholangitis disease severity and prognosis","volume":"66","author":"Vesterhus","year":"2017","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.bbadis.2017.09.012_bb0165","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1136\/gutjnl-2012-302047","article-title":"Urine proteomic analysis differentiates cholangiocarcinoma from primary sclerosing cholangitis and other benign biliary disorders","volume":"62","author":"Metzger","year":"2013","journal-title":"Gut"},{"issue":"2","key":"10.1016\/j.bbadis.2017.09.012_bb0170","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1093\/gastro\/gou066","article-title":"Bile proteomics for differentiation of malignant from benign biliary strictures: a pilot study","volume":"3","author":"Navaneethan","year":"2015","journal-title":"Gastroenterol Rep. (Oxf)."},{"issue":"4","key":"10.1016\/j.bbadis.2017.09.012_bb0175","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1002\/hep.27840","article-title":"The biliary epithelium presents antigens to and activates natural killer T cells","volume":"62","author":"Schrumpf","year":"2015","journal-title":"Hepatology"},{"issue":"7","key":"10.1016\/j.bbadis.2017.09.012_bb0180","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1136\/gutjnl-2016-312278","article-title":"Wnt signalling modulates transcribed-ultraconserved regions in hepatobiliary cancers","volume":"66","author":"Carotenuto","year":"2017","journal-title":"Gut"},{"issue":"3","key":"10.1016\/j.bbadis.2017.09.012_bb0185","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1172\/JCI76452","article-title":"WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited","volume":"125","author":"Boulter","year":"2015","journal-title":"J. Clin. Invest."},{"issue":"8","key":"10.1016\/j.bbadis.2017.09.012_bb0190","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1097\/MIB.0b013e318281f49a","article-title":"Genetic and epigenetic abnormalities in primary sclerosing cholangitis-associated cholangiocarcinoma","volume":"19","author":"Timmer","year":"2013","journal-title":"Inflamm. Bowel Dis."},{"issue":"3","key":"10.1016\/j.bbadis.2017.09.012_bb0195","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/j.1365-2249.2010.04200.x","article-title":"Circulating CD14(+) CD16(+) monocyte levels predict tissue invasive character of cholangiocarcinoma","volume":"161","author":"Subimerb","year":"2010","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.bbadis.2017.09.012_bb0200","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.cca.2015.05.016","article-title":"Annexin A4 and cancer","volume":"447","author":"Wei","year":"2015","journal-title":"Clin. Chim. Acta"},{"issue":"5","key":"10.1016\/j.bbadis.2017.09.012_bb0205","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/nrgastro.2016.51","article-title":"Expert consensus document: Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA)","volume":"13","author":"Banales","year":"2016","journal-title":"Nat. Rev. Gastroenterol. Hepatol."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443917303277?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443917303277?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T04:41:46Z","timestamp":1760416906000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443917303277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["S0925443917303277"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2017.09.012","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pathological features of primary sclerosing cholangitis identified by bile proteomic analysis","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2017.09.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V.","name":"copyright","label":"Copyright"}]}}