{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:42:14Z","timestamp":1790109734806,"version":"4.0.1"},"reference-count":72,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"publisher","award":["E-26\/171.137\/2006"],"award-info":[{"award-number":["E-26\/171.137\/2006"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"publisher","award":["E-26\/111.665\/2008"],"award-info":[{"award-number":["E-26\/111.665\/2008"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Research Council","award":["303135\/2015-8"],"award-info":[{"award-number":["303135\/2015-8"]}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["420584\/2013-7"],"award-info":[{"award-number":["420584\/2013-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"NIDDK","doi-asserted-by":"publisher","award":["DK104375"],"award-info":[{"award-number":["DK104375"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.bbadis.2017.10.005","type":"journal-article","created":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T08:46:58Z","timestamp":1507711618000},"page":"102-114","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"title":["Protective outcomes of low-dose doxycycline on renal function of Wistar rats subjected to acute ischemia\/reperfusion injury"],"prefix":"10.1016","volume":"1864","author":[{"given":"Aline L.","family":"Cortes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina R.","family":"Gonsalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilimar S.","family":"Rioja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone S.C.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 L.S.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minolfa C.","family":"Prieto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo A.","family":"Melo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucienne S.","family":"Lara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2017.10.005_bb0005","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.2215\/CJN.00710113","article-title":"World incidence of AKI: a meta-analysis","volume":"8","author":"Susantitaphong","year":"2013","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0010","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/S0140-6736(11)61454-2","article-title":"Acute kidney injury","volume":"380","author":"Bellomo","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.bbadis.2017.10.005_bb0015","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s40697-015-0062-9","article-title":"Acute kidney injury: preclinical innovations, challenges, and opportunities for translation","volume":"2","author":"Silver","year":"2015","journal-title":"Can. J. Kidney Health Dis."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0020","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/ki.2011.379","article-title":"Chronic kidney disease after acute kidney injury: a systematic review and meta-analysis","volume":"81","author":"Coca","year":"2012","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0025","first-page":"503","article-title":"The role of the microcirculation in acute kidney injury","volume":"15","author":"Le Dorze","year":"2009","journal-title":"Curr. Opin. Crit. Care"},{"key":"10.1016\/j.bbadis.2017.10.005_bb0030","doi-asserted-by":"crossref","first-page":"4210","DOI":"10.1172\/JCI45161","article-title":"Cellular pathophysiology of ischemic acute kidney injury","volume":"121","author":"Bonventre","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0035","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1741-7015-9-11","article-title":"Advances in understanding ischemic acute kidney injury","volume":"9","author":"Munshi","year":"2011","journal-title":"BMC Med."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0040","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1146\/annurev.pharmtox.47.120505.105230","article-title":"Intracellular targets of matrix metalloproteinase-2 in cardiac disease: rationale and therapeutic approaches","volume":"47","author":"Schulz","year":"2007","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0045","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.coph.2007.12.001","article-title":"Multiphasic roles for matrix metalloproteinases after stroke","volume":"8","author":"Rosell","year":"2008","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0050","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/sj.bjp.0707344","article-title":"Acute actions and novel targets of matrix metalloproteinases in the heart and vasculature","volume":"152","author":"Chow","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0055","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.yjmcc.2014.09.016","article-title":"Myocardial matrix metalloproteinase-2: inside out and upside down","volume":"77","author":"Lindsey","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0060","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.mam.2011.10.015","article-title":"Human matrix metalloproteinases: an ubiquitarian class of enzymes involved in several pathological processes","volume":"33","author":"Sbardella","year":"2012","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0065","doi-asserted-by":"crossref","first-page":"F1351","DOI":"10.1152\/ajprenal.00037.2012","article-title":"Matrix metalloproteinases in kidney homeostasis and diseases","volume":"302","author":"Tan","year":"2012","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0070","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1097\/SHK.0000000000000257","article-title":"Doxycycline attenuates renal injury in a swine model of neonatal hypoxia-reoxygenation","volume":"43","author":"Labossiere","year":"2015","journal-title":"Shock"},{"key":"10.1016\/j.bbadis.2017.10.005_bb0075","doi-asserted-by":"crossref","first-page":"F905","DOI":"10.1152\/ajprenal.00421.2006","article-title":"Role of matrix metalloproteinases in renal pathophysiologies","volume":"292","author":"Catania","year":"2007","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0080","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.phrs.2011.05.002","article-title":"Matrix metalloproteinase inhibition with tetracyclines for the treatment of coronary artery disease","volume":"64","author":"Bench","year":"2011","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0085","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1159\/000346569","article-title":"Role of matrix metalloproteinase-2 in recovery after tubular damage in acute kidney injury in mice","volume":"122","author":"Kaneko","year":"2012","journal-title":"Nephron Exp. Nephrol."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0090","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1093\/ndt\/gfs387","article-title":"Experimental diabetic nephropathy is accelerated in matrix metalloproteinase-2 knockout mice","volume":"28","author":"Takamiya","year":"2013","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0095","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/tri.12445","article-title":"Renal dysfunction and intragraft proMMP9 activity in renal transplant recipients with interstitial fibrosis and tubular atrophy","volume":"28","author":"Racca","year":"2015","journal-title":"Transpl. Int."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0143390","article-title":"Matrix metalloproteinase-2 knockout and heterozygote mice are protected from hydronephrosis and kidney fibrosis after unilateral ureteral obstruction","volume":"10","author":"Tveitaras","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2017.10.005_bb0105","first-page":"H87","article-title":"Doxycycline, a matrix metalloprotease inhibitor, reduces vascular remodeling and damage after cerebral ischemia in stroke-prone spontaneously hypertensive rats","volume":"301","author":"Pires","year":"2011","journal-title":"Am. J. Phys. Heart Circ. Phys."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0110","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1177\/08959374980120010501","article-title":"Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms","volume":"12","author":"Golub","year":"1998","journal-title":"Adv. Dent. Res."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0115","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/S0741-5214(98)70035-7","article-title":"Pharmacologic suppression of experimental abdominal aortic aneurysms: a comparison of doxycycline and four chemically modified tetracyclines","volume":"28","author":"Curci","year":"1998","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0120","doi-asserted-by":"crossref","first-page":"42","DOI":"10.2174\/157489011794578419","article-title":"Effect of doxycycline on atherosclerosis: from bench to bedside","volume":"6","author":"Rodriguez-Granillo","year":"2011","journal-title":"Recent Pat. Cardiovasc. Drug Discov."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0125","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jtos.2015.11.006","article-title":"Differential effects of dexamethasone and doxycycline on inflammation and MMP production in alkali-burned corneas associated with dry eye","volume":"14","author":"Bian","year":"2016","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0130","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.niox.2012.01.009","article-title":"Doxycycline ameliorates 2K-1C hypertension-induced vascular dysfunction in rats by attenuating oxidative stress and improving nitric oxide bioavailability","volume":"26","author":"Castro","year":"2012","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.bbadis.2017.10.005_bb0135","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/1471-2369-13-109","article-title":"Increasing extracellular matrix collagen level and MMP activity induces cyst development in polycystic kidney disease","volume":"13","author":"Liu","year":"2012","journal-title":"BMC Nephrol."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0140","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1111\/j.1440-1797.2010.01289.x","article-title":"Decrease in cell proliferation by an matrix metalloproteinase inhibitor, doxycycline, in a model of immune-complex nephritis","volume":"15","author":"Saglam","year":"2010","journal-title":"Nephrology"},{"key":"10.1016\/j.bbadis.2017.10.005_bb0145","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jss.2009.09.048","article-title":"Effects of doxycycline on renal ischemia reperfusion injury induced by abdominal compartment syndrome","volume":"167","author":"Ihtiyar","year":"2011","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0150","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/BF03179069","article-title":"Protective effects of doxycycline in ischemia\/reperfusion injury on kidney","volume":"65","author":"Kucuk","year":"2009","journal-title":"J. Physiol. Biochem."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0155","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3727\/096368912X659862","article-title":"The impact of stem cells on electron fluxes, proton translocation, and ATP synthesis in kidney mitochondria after ischemia\/reperfusion","volume":"23","author":"Beiral","year":"2014","journal-title":"Cell Transplant."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0160","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/ki.1974.52","article-title":"Doxycycline pharmacokinetics in the absence of renal function","volume":"5","author":"Whelton","year":"1974","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0165","doi-asserted-by":"crossref","first-page":"F85","DOI":"10.1152\/ajprenal.00351.2011","article-title":"AT1 receptor-mediated augmentation of angiotensinogen, oxidative stress, and inflammation in ANG II-salt hypertension","volume":"302","author":"Lara","year":"2012","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0170","doi-asserted-by":"crossref","first-page":"F105","DOI":"10.1152\/ajprenal.00490.2011","article-title":"The sodium-activated sodium channel is expressed in the rat kidney thick ascending limb and collecting duct cells and is upregulated during high salt intake","volume":"303","author":"Lara","year":"2012","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0175","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.bbamem.2009.06.018","article-title":"Na+-ATPase in spontaneous hypertensive rats: possible AT(1) receptor target in the development of hypertension","volume":"1798","author":"Queiroz-Madeira","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2017.10.005_bb0180","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0185","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0004918","article-title":"HIV aspartyl peptidase inhibitors interfere with cellular proliferation, ultrastructure and macrophage infection of Leishmania amazonensis","volume":"4","author":"Santos","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2017.10.005_bb0190","article-title":"Detection of functional matrix metalloproteinases by zymography","volume":"45","author":"Hu","year":"2010","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0195","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ijpara.2005.09.004","article-title":"Phytomonas serpens: cysteine peptidase inhibitors interfere with growth, ultrastructure and host adhesion","volume":"36","author":"Santos","year":"2006","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0200","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1002\/j.2040-4603.2012.tb00431.x","article-title":"Pathophysiology of acute kidney injury","volume":"2","author":"Basile","year":"2012","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0205","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ddmod.2014.06.004","article-title":"Animal models of kidney inflammation in translational medicine","volume":"11","author":"Holderied","year":"2014","journal-title":"Drug Discov. Today Dis. Model."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0210","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/ki.2013.157","article-title":"Progressive endothelin-1 gene activation initiates chronic\/end-stage renal disease following experimental ischemic\/reperfusion injury","volume":"84","author":"Zager","year":"2013","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0215","doi-asserted-by":"crossref","first-page":"F887","DOI":"10.1152\/ajprenal.00050.2001","article-title":"Renal ischemic injury results in permanent damage to peritubular capillaries and influences long-term function","volume":"281","author":"Basile","year":"2001","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0220","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/ki.2008.602","article-title":"Renal ischemia-reperfusion leads to long term infiltration of activated and effector-memory T lymphocytes","volume":"75","author":"Ascon","year":"2009","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0225","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1681\/ASN.2004080678","article-title":"Hematopoietic stem cell mobilization therapy accelerates recovery of renal function independent of stem cell contribution","volume":"16","author":"Stokman","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0230","doi-asserted-by":"crossref","first-page":"F688","DOI":"10.1152\/ajprenal.00452.2006","article-title":"Acute and chronic microvascular alterations in a mouse model of ischemic acute kidney injury","volume":"293","author":"Horbelt","year":"2007","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0235","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nm.2144","article-title":"Epithelial cell cycle arrest in G2\/M mediates kidney fibrosis after injury","volume":"16","author":"Yang","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0240","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/ki.2012.20","article-title":"Targeted proximal tubule injury triggers interstitial fibrosis and glomerulosclerosis","volume":"82","author":"Grgic","year":"2012","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0245","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/ki.1995.112","article-title":"Localization of transforming growth factor-beta and latent transforming growth factor-beta binding protein in rat kidney","volume":"47","author":"Ando","year":"1995","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0250","first-page":"901","article-title":"Differential role of mesangial cells and podocytes in TGF-\u03b2-induced mesangial matrix synthesis in chronic glomerular disease","volume":"24","author":"Lee","year":"2009","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0255","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1097\/TP.0b013e3182301602","article-title":"Estimating glomerular filtration rate in kidney transplant recipients: performance over time of four creatinine-based formulas","volume":"92","author":"Buron","year":"2011","journal-title":"Transplantation"},{"key":"10.1016\/j.bbadis.2017.10.005_bb0260","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/j.1742-7843.2010.00656.x","article-title":"Doxycycline dose-dependently inhibits MMP-2-mediated vascular changes in 2K1C hypertension","volume":"108","author":"Guimar\u00e3es","year":"2011","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0265","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1093\/infdis\/132.4.467","article-title":"Pharmacokinetic characteristics of doxycycline accumulation in normal and severely diseased kidneys","volume":"132","author":"Whelton","year":"1975","journal-title":"J Infect Dis"},{"key":"10.1016\/j.bbadis.2017.10.005_bb0270","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1067\/mva.2002.123757","article-title":"Doxycycline in patients with abdominal aortic aneurysms and in mice: comparison of serum levels and effect on aneurysm growth in mice","volume":"35","author":"Prall","year":"2002","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0275","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s11010-013-1848-7","article-title":"Antioxidant effect of doxycycline decreases MMP activity and blood pressure in SHR","volume":"386","author":"Antonio","year":"2014","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0280","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1097\/SHK.0000000000000213","article-title":"Minocycline and doxycycline, but not tetracycline, mitigate liver and kidney injury after hemorrhagic shock\/resuscitation","volume":"42","author":"Kholmukhamedov","year":"2014","journal-title":"Shock"},{"key":"10.1016\/j.bbadis.2017.10.005_bb0285","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1177\/08959374980120010301","article-title":"Inhibition of MMP synthesis by doxycycline and chemically modified tetracyclines (CMTs) in human endothelial cells","volume":"12","author":"Hanemaaijer","year":"1998","journal-title":"Adv. Dent. Res."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0290","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/S0741-5214(03)01022-X","article-title":"Mechanism of inhibition of matrix metalloproteinase-2 expression by doxycycline in human aortic smooth muscle cells","volume":"38","author":"Liu","year":"2003","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0295","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1164\/rccm.201401-0077OC","article-title":"Validation of cell-cycle arrest biomarkers for acute kidney injury using clinical adjudication","volume":"189","author":"Bihorac","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0300","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1159\/000052602","article-title":"Renal matrix metalloproteinase activity is unaffected by experimental ischemia-reperfusion injury and matrix metalloproteinase inhibition does not alter outcome of renal function","volume":"9","author":"Ziswiler","year":"2001","journal-title":"Exp. Nephrol."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0305","first-page":"490","article-title":"Mechanisms of cellular injury in ischemic acute renal failure","volume":"18","author":"Sutton","year":"1998","journal-title":"Semin. Nephrol."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0310","first-page":"F623","article-title":"Acute renal failure. I. Relative importance of proximal vs. distal tubular injury","volume":"275","author":"Lieberthal","year":"1998","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0315","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/ki.2009.347","article-title":"Experimental ischemia-reperfusion: biases and myths-the proximal vs. distal hypoxic tubular injury debate revisited","volume":"77","author":"Heyman","year":"2010","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0320","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1097\/MOP.0b013e328343f4dd","article-title":"Biomarkers for the early detection of acute kidney injury","volume":"23","author":"Devarajan","year":"2011","journal-title":"Curr. Opin. Pediatr."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0325","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.regpep.2004.12.007","article-title":"PI-PLCbeta is involved in the modulation of the proximal tubule Na+-ATPase by angiotensin II","volume":"127","author":"Rangel","year":"2005","journal-title":"Regul. Pept."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0330","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1113\/expphysiol.2007.040584","article-title":"The angiotensin receptor type 1-Gq protein-phosphatidyl inositol phospholipase Cbeta-protein kinase C pathway is involved in activation of proximal tubule Na+-ATPase activity by angiotensin(1-7) in pig kidneys","volume":"93","author":"Lara","year":"2008","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0335","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1016\/j.bbamem.2011.02.010","article-title":"Isolation and cloning of the K+-independent, ouabain-insensitive Na+-ATPase","volume":"1808","author":"Rocafull","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2017.10.005_bb0340","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1016\/j.bbadis.2014.09.017","article-title":"Altered signaling pathways linked to angiotensin II underpin the upregulation of renal Na+-ATPase in chronically undernourished rats","volume":"1842","author":"Silva","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2017.10.005_bb0345","series-title":"The Role of the Second Na+ Pump in Mamals and Parasites","first-page":"93","article-title":"Regulation of membrane Na+-K+ ATPase","author":"Chakraborti","year":"2015"},{"key":"10.1016\/j.bbadis.2017.10.005_bb0350","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1152\/japplphysiol.01239.2012","article-title":"Activation of proteases and changes in Na+-K+-ATPase subunits in hearts subjected to ischemia-reperfusion","volume":"114","author":"M\u00fcller","year":"2013","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0355","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1681\/ASN.2014030288","article-title":"Gut bacteria products prevent AKI induced by ischemia-reperfusion","volume":"26","author":"Andrade-Oliveira","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbadis.2017.10.005_bb0360","series-title":"Mechanisms of Plaque Rupture","first-page":"61","article-title":"Mechanisms of vascular disease: a reference book for vascular specialists","author":"Fitridge","year":"2011"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443917303605?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443917303605?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T04:40:17Z","timestamp":1760416817000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443917303605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":72,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["S0925443917303605"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2017.10.005","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective outcomes of low-dose doxycycline on renal function of Wistar rats subjected to acute ischemia\/reperfusion injury","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2017.10.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V.","name":"copyright","label":"Copyright"}]}}