{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T22:52:48Z","timestamp":1784328768473,"version":"3.55.0"},"reference-count":81,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Netherlands Organisation for Scientific Research","doi-asserted-by":"publisher","award":["916.14.050"],"award-info":[{"award-number":["916.14.050"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.bbadis.2017.12.025","type":"journal-article","created":{"date-parts":[[2017,12,20]],"date-time":"2017-12-20T03:01:08Z","timestamp":1513738868000},"page":"1960-1967","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"PB","title":["Human embryonic stem cell-derived cardiomyocytes as an in vitro model to study cardiac insulin resistance"],"prefix":"10.1016","volume":"1864","author":[{"given":"Ilvy M.E.","family":"Geraets","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipanjan","family":"Chanda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence H.J.","family":"van Tienen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"van den Wijngaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick","family":"Kamps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietbert","family":"Neumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan F.C.","family":"Glatz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost J.F.P.","family":"Luiken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda","family":"Nabben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.bbadis.2017.12.025_bb0005","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.2337\/dc11-0442","article-title":"Globalization of diabetes: the role of diet, lifestyle, and genes","volume":"34","author":"Hu","year":"2011","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bbadis.2017.12.025_bb0010","author":"World Health Organization"},{"issue":"7","key":"10.1016\/j.bbadis.2017.12.025_bb0015","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1007\/s00125-010-1684-1","article-title":"Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009","volume":"53","author":"DeFronzo","year":"2010","journal-title":"Diabetologia"},{"issue":"7","key":"10.1016\/j.bbadis.2017.12.025_bb0020","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.cardfail.2008.04.001","article-title":"Heart failure and diabetes mellitus: epidemiology and management of an alarming association","volume":"14","author":"Cohen-Solal","year":"2008","journal-title":"J. Card. Fail."},{"issue":"1","key":"10.1016\/j.bbadis.2017.12.025_bb0025","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0002-9149(74)90089-7","article-title":"Role of diabetes in congestive heart failure: the Framingham study","volume":"34","author":"Kannel","year":"1974","journal-title":"Am. J. Cardiol."},{"issue":"6","key":"10.1016\/j.bbadis.2017.12.025_bb0030","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1067\/mhj.2001.115302","article-title":"Relationship of impaired glucose tolerance to left ventricular structure and function: the Strong Heart Study","volume":"141","author":"Ilercil","year":"2001","journal-title":"Am. Heart J."},{"issue":"2","key":"10.1016\/j.bbadis.2017.12.025_bb0035","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0300-595X(82)80017-0","article-title":"The definition and classification of diabetes mellitus","volume":"11","author":"Keen","year":"1982","journal-title":"Clin. Endocrinol. Metab."},{"issue":"7121","key":"10.1016\/j.bbadis.2017.12.025_bb0040","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1038\/nature05482","article-title":"Mechanisms linking obesity to insulin resistance and type 2 diabetes","volume":"444","author":"Kahn","year":"2006","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.bbadis.2017.12.025_bb0045","doi-asserted-by":"crossref","first-page":"H1489","DOI":"10.1152\/ajpheart.00278.2006","article-title":"Role of changes in cardiac metabolism in development of diabetic cardiomyopathy","volume":"291","author":"An","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"2","key":"10.1016\/j.bbadis.2017.12.025_bb0050","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1023\/A:1015328625394","article-title":"Metabolic abnormalities in the diabetic heart","volume":"7","author":"Lopaschuk","year":"2002","journal-title":"Heart Fail. Rev."},{"issue":"19","key":"10.1016\/j.bbadis.2017.12.025_bb0055","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1001\/jama.1979.03290450033020","article-title":"Diabetes and cardiovascular disease. The Framingham study","volume":"241","author":"Kannel","year":"1979","journal-title":"JAMA"},{"issue":"3","key":"10.1016\/j.bbadis.2017.12.025_bb0060","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.tcm.2010.08.001","article-title":"Cardiovascular disease risk factors, type 2 diabetes mellitus, and the Framingham Heart Study","volume":"20","author":"Fox","year":"2010","journal-title":"Trends Cardiovasc. Med."},{"issue":"3","key":"10.1016\/j.bbadis.2017.12.025_bb0065","first-page":"70","article-title":"Small mammalian animal models of heart disease","volume":"6","author":"Camacho","year":"2016","journal-title":"Am. J. Cardiovasc. Dis."},{"issue":"10","key":"10.1016\/j.bbadis.2017.12.025_bb0070","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1161\/RES.0000000000000097","article-title":"Assessing cardiac metabolism: a scientific statement from the American Heart Association","volume":"118","author":"Taegtmeyer","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbadis.2017.12.025_bb0075","article-title":"Isolation and functional characterization of human ventricular cardiomyocytes from fresh surgical samples","volume":"86","author":"Coppini","year":"2014","journal-title":"J. Vis. Exp."},{"issue":"3","key":"10.1016\/j.bbadis.2017.12.025_bb0080","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3233\/JND-150133","article-title":"Can human pluripotent stem cell-derived cardiomyocytes advance understanding of muscular dystrophies?","volume":"3","author":"Kalra","year":"2016","journal-title":"J. Neuromuscul. Dis."},{"issue":"1","key":"10.1016\/j.bbadis.2017.12.025_bb0085","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.yjmcc.2005.03.003","article-title":"Novel cell lines derived from adult human ventricular cardiomyocytes","volume":"39","author":"Davidson","year":"2005","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbadis.2017.12.025_bb0090","doi-asserted-by":"crossref","DOI":"10.1038\/srep36207","article-title":"MicroRNA-126 overexpression rescues diabetes-induced impairment in efferocytosis of apoptotic cardiomyocytes","volume":"6","author":"Suresh Babu","year":"2016","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.bbadis.2017.12.025_bb0095","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.bbrc.2016.02.065","article-title":"MicroRNA-9 inhibits hyperglycemia-induced pyroptosis in human ventricular cardiomyocytes by targeting ELAVL1","volume":"471","author":"Jeyabal","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbadis.2017.12.025_bb0100","article-title":"Variability of action potentials within and among cardiac cell clusters derived from human embryonic stem cells","volume":"6","author":"Zhu","year":"2016","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/j.bbadis.2017.12.025_bb0105","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.tips.2009.07.001","article-title":"Cardiomyocytes from human pluripotent stem cells in regenerative medicine and drug discovery","volume":"30","author":"Braam","year":"2009","journal-title":"Trends Pharmacol. Sci."},{"issue":"4","key":"10.1016\/j.bbadis.2017.12.025_bb0110","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1097\/FJC.0b013e318247f642","article-title":"Induced pluripotent stem cells as a disease modeling and drug screening platform","volume":"60","author":"Ebert","year":"2012","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"3","key":"10.1016\/j.bbadis.2017.12.025_bb0115","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1161\/CIRCRESAHA.114.300558","article-title":"Engineering adolescence: maturation of human pluripotent stem cell-derived cardiomyocytes","volume":"114","author":"Yang","year":"2014","journal-title":"Circ. Res."},{"issue":"Pt 3","key":"10.1016\/j.bbadis.2017.12.025_bb0120","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1046\/j.1469-7580.2002.00032.x","article-title":"Derivation and spontaneous differentiation of human embryonic stem cells","volume":"200","author":"Amit","year":"2002","journal-title":"J. Anat."},{"issue":"21","key":"10.1016\/j.bbadis.2017.12.025_bb0125","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1161\/01.CIR.0000068356.38592.68","article-title":"Differentiation of human embryonic stem cells to cardiomyocytes: role of coculture with visceral endoderm-like cells","volume":"107","author":"Mummery","year":"2003","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.bbadis.2017.12.025_bb0130","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1161\/01.RES.0000080317.92718.99","article-title":"Human embryonic stem cells develop into multiple types of cardiac myocytes: action potential characterization","volume":"93","author":"He","year":"2003","journal-title":"Circ. Res."},{"issue":"3","key":"10.1016\/j.bbadis.2017.12.025_bb0135","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1161\/CIRCRESAHA.110.227512","article-title":"Differentiation of human embryonic stem cells and induced pluripotent stem cells to cardiomyocytes: a methods overview","volume":"111","author":"Mummery","year":"2012","journal-title":"Circ. Res."},{"issue":"9","key":"10.1016\/j.bbadis.2017.12.025_bb0140","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1089\/scd.2014.0533","article-title":"Immaturity of human stem-cell-derived cardiomyocytes in culture: fatal flaw or soluble problem?","volume":"24","author":"Veerman","year":"2015","journal-title":"Stem Cells Dev."},{"issue":"1","key":"10.1016\/j.bbadis.2017.12.025_bb0145","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1161\/CIRCRESAHA.117.305365","article-title":"Human induced pluripotent stem cell-derived cardiomyocytes: insights into molecular, cellular, and functional phenotypes","volume":"117","author":"Karakikes","year":"2015","journal-title":"Circ. Res."},{"issue":"5","key":"10.1016\/j.bbadis.2017.12.025_bb0150","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","article-title":"Induction of pluripotent stem cells from adult human fibroblasts by defined factors","volume":"131","author":"Takahashi","year":"2007","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.bbadis.2017.12.025_bb0155","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1038\/nprot.2008.92","article-title":"Generation of human-induced pluripotent stem cells","volume":"3","author":"Park","year":"2008","journal-title":"Nat. Protoc."},{"issue":"7","key":"10.1016\/j.bbadis.2017.12.025_bb0160","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1681\/ASN.2011010106","article-title":"Generation of induced pluripotent stem cells from urine","volume":"22","author":"Zhou","year":"2011","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbadis.2017.12.025_bb0165","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/768391","article-title":"A comparative view on human somatic cell sources for iPSC generation","volume":"2014","author":"Raab","year":"2014","journal-title":"Stem Cells Int."},{"issue":"12","key":"10.1016\/j.bbadis.2017.12.025_bb0170","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1038\/nprot.2012.115","article-title":"Generation of human induced pluripotent stem cells from urine samples","volume":"7","author":"Zhou","year":"2012","journal-title":"Nat. Protoc."},{"issue":"18","key":"10.1016\/j.bbadis.2017.12.025_bb0175","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1016\/j.jacc.2016.01.083","article-title":"Translation of human-induced pluripotent stem cells: from clinical trial in a dish to precision medicine","volume":"67","author":"Sayed","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"issue":"14","key":"10.1016\/j.bbadis.2017.12.025_bb0180","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1089\/scd.2012.0490","article-title":"Structural and functional maturation of cardiomyocytes derived from human pluripotent stem cells","volume":"22","author":"Lundy","year":"2013","journal-title":"Stem Cells Dev."},{"issue":"5","key":"10.1016\/j.bbadis.2017.12.025_bb0185","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1002\/stem.1331","article-title":"Concise review: maturation phases of human pluripotent stem cell-derived cardiomyocytes","volume":"31","author":"Robertson","year":"2013","journal-title":"Stem Cells"},{"issue":"4","key":"10.1016\/j.bbadis.2017.12.025_bb0190","doi-asserted-by":"crossref","first-page":"e30","DOI":"10.1161\/CIRCRESAHA.108.192237","article-title":"Functional cardiomyocytes derived from human induced pluripotent stem cells","volume":"104","author":"Zhang","year":"2009","journal-title":"Circ. Res."},{"issue":"7","key":"10.1016\/j.bbadis.2017.12.025_bb0195","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1634\/stemcells.2007-1033","article-title":"Molecular signature of cardiomyocyte clusters derived from human embryonic stem cells","volume":"26","author":"Synnergren","year":"2008","journal-title":"Stem Cells"},{"issue":"2","key":"10.1016\/j.bbadis.2017.12.025_bb0200","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.stem.2010.12.008","article-title":"Stage-specific optimization of activin\/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines","volume":"8","author":"Kattman","year":"2011","journal-title":"Cell Stem Cell"},{"issue":"5","key":"10.1016\/j.bbadis.2017.12.025_bb0205","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1440-169X.2005.00803.x","article-title":"Molecular analysis of cardiomyocytes derived from human embryonic stem cells","volume":"47","author":"Segev","year":"2005","journal-title":"Develop. Growth Differ."},{"issue":"8","key":"10.1016\/j.bbadis.2017.12.025_bb0210","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/nmeth.2999","article-title":"Chemically defined generation of human cardiomyocytes","volume":"11","author":"Burridge","year":"2014","journal-title":"Nat. Methods"},{"issue":"7194","key":"10.1016\/j.bbadis.2017.12.025_bb0215","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/nature06894","article-title":"Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population","volume":"453","author":"Yang","year":"2008","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.bbadis.2017.12.025_bb0220","doi-asserted-by":"crossref","first-page":"a004242","DOI":"10.1101\/cshperspect.a004242","article-title":"Calcium signaling in cardiac myocytes","volume":"3","author":"Fearnley","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.bbadis.2017.12.025_bb0225","first-page":"380","article-title":"Altered cardiac myocyte Ca regulation in heart failure","volume":"21","author":"Bers","year":"2006","journal-title":"Physiology (Bethesda)"},{"issue":"5","key":"10.1016\/j.bbadis.2017.12.025_bb0230","doi-asserted-by":"crossref","first-page":"H2006","DOI":"10.1152\/ajpheart.00694.2011","article-title":"High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents","volume":"301","author":"Ma","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"4","key":"10.1016\/j.bbadis.2017.12.025_bb0235","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1258\/ebm.2010.009345","article-title":"Human embryonic stem cell-derived cardiomyocytes: demonstration of a portion of cardiac cells with fairly mature electrical phenotype","volume":"235","author":"Pekkanen-Mattila","year":"2010","journal-title":"Exp. Biol. Med. (Maywood)"},{"issue":"6","key":"10.1016\/j.bbadis.2017.12.025_bb0240","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1089\/scd.2009.0349","article-title":"Non-cardiomyocytes influence the electrophysiological maturation of human embryonic stem cell-derived cardiomyocytes during differentiation","volume":"19","author":"Kim","year":"2010","journal-title":"Stem Cells Dev."},{"issue":"10","key":"10.1016\/j.bbadis.2017.12.025_bb0245","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1089\/scd.2011.0682","article-title":"The expression of the class 1 glucose transporter isoforms in human embryonic stem cells, and the potential use of GLUT2 as a marker for pancreatic progenitor enrichment","volume":"21","author":"Segev","year":"2012","journal-title":"Stem Cells Dev."},{"issue":"1","key":"10.1016\/j.bbadis.2017.12.025_bb0250","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/cphy.c150016","article-title":"Glucose transporters in cardiac metabolism and hypertrophy","volume":"6","author":"Shao","year":"2015","journal-title":"Comp. Physiol."},{"issue":"1","key":"10.1016\/j.bbadis.2017.12.025_bb0255","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1152\/physrev.00003.2009","article-title":"Membrane fatty acid transporters as regulators of lipid metabolism: implications for metabolic disease","volume":"90","author":"Glatz","year":"2010","journal-title":"Physiol. Rev."},{"issue":"Suppl. 1","key":"10.1016\/j.bbadis.2017.12.025_bb0260","doi-asserted-by":"crossref","first-page":"S60","DOI":"10.1038\/ncpcardio0766","article-title":"Mitochondrial oxidative metabolism is required for the cardiac differentiation of stem cells","volume":"4","author":"Chung","year":"2007","journal-title":"Nat. Clin. Pract. Cardiovasc. Med."},{"issue":"1","key":"10.1016\/j.bbadis.2017.12.025_bb0265","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.stem.2012.09.013","article-title":"Distinct metabolic flow enables large-scale purification of mouse and human pluripotent stem cell-derived cardiomyocytes","volume":"12","author":"Tohyama","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bbadis.2017.12.025_bb0270","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/5153625","article-title":"Mitochondrial maturation in human pluripotent stem cell derived cardiomyocytes","volume":"2017","author":"Dai","year":"2017","journal-title":"Stem Cells Int."},{"issue":"1","key":"10.1016\/j.bbadis.2017.12.025_bb0275","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/nmeth.1403","article-title":"Nongenetic method for purifying stem cell-derived cardiomyocytes","volume":"7","author":"Hattori","year":"2010","journal-title":"Nat. Methods"},{"issue":"3","key":"10.1016\/j.bbadis.2017.12.025_bb0280","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1089\/clo.2005.7.141","article-title":"The expression of mitochondrial DNA transcription factors during early cardiomyocyte in vitro differentiation from human embryonic stem cells","volume":"7","author":"St John","year":"2005","journal-title":"Cloning Stem Cells"},{"issue":"3","key":"10.1016\/j.bbadis.2017.12.025_bb0285","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1021\/acs.jproteome.6b00534","article-title":"Proteomic analysis of human pluripotent stem cell cardiomyogenesis revealed altered expression of metabolic enzymes and PDLIM5 isoforms","volume":"16","author":"Konze","year":"2017","journal-title":"J. Proteome Res."},{"issue":"4","key":"10.1016\/j.bbadis.2017.12.025_bb0290","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1210\/en.2009-1211","article-title":"Activation of peroxisome proliferator-activated receptor-{delta} by GW501516 prevents fatty acid-induced nuclear factor-{kappa}B activation and insulin resistance in skeletal muscle cells","volume":"151","author":"Coll","year":"2010","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.bbadis.2017.12.025_bb0295","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1007\/s00125-011-2328-9","article-title":"Endoplasmic reticulum stress does not mediate palmitate-induced insulin resistance in mouse and human muscle cells","volume":"55","author":"Hage Hassan","year":"2012","journal-title":"Diabetologia"},{"issue":"6","key":"10.1016\/j.bbadis.2017.12.025_bb0300","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.2337\/db16-0727","article-title":"Palmitate-induced vacuolar-type H(+)-ATPase inhibition feeds forward into insulin resistance and contractile dysfunction","volume":"66","author":"Liu","year":"2017","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.bbadis.2017.12.025_bb0305","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1042\/BJ20120060","article-title":"CD36 inhibition prevents lipid accumulation and contractile dysfunction in rat cardiomyocytes","volume":"448","author":"Angin","year":"2012","journal-title":"Biochem. J."},{"issue":"9","key":"10.1016\/j.bbadis.2017.12.025_bb0310","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1007\/s00125-007-0735-8","article-title":"Cardiac contractile dysfunction in insulin-resistant rats fed a high-fat diet is associated with elevated CD36-mediated fatty acid uptake and esterification","volume":"50","author":"Ouwens","year":"2007","journal-title":"Diabetologia"},{"issue":"44","key":"10.1016\/j.bbadis.2017.12.025_bb0315","doi-asserted-by":"crossref","first-page":"37530","DOI":"10.1074\/jbc.M112.363630","article-title":"Overexpression of vesicle-associated membrane protein (VAMP) 3, but not VAMP2, protects glucose transporter (GLUT) 4 protein translocation in an in vitro model of cardiac insulin resistance","volume":"287","author":"Schwenk","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.bbadis.2017.12.025_bb0320","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.pharmthera.2013.10.007","article-title":"Small and large animal models in cardiac contraction research: advantages and disadvantages","volume":"141","author":"Milani-Nejad","year":"2014","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bbadis.2017.12.025_bb0325","doi-asserted-by":"crossref","DOI":"10.1038\/srep22788","article-title":"Insulin resistance in human iPS cells reduces mitochondrial size and function","volume":"6","author":"Burkart","year":"2016","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.bbadis.2017.12.025_bb0330","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1073\/pnas.1525665113","article-title":"Myotubes derived from human-induced pluripotent stem cells mirror in vivo insulin resistance","volume":"113","author":"Iovino","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.bbadis.2017.12.025_bb0335","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1210\/en.2014-1403","article-title":"Severe insulin resistance alters metabolism in mesenchymal progenitor cells","volume":"156","author":"Balhara","year":"2015","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.bbadis.2017.12.025_bb0340","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.celrep.2014.09.055","article-title":"Disease modeling and phenotypic drug screening for diabetic cardiomyopathy using human induced pluripotent stem cells","volume":"9","author":"Drawnel","year":"2014","journal-title":"Cell Rep."},{"issue":"3","key":"10.1016\/j.bbadis.2017.12.025_bb0345","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1172\/JCI200112131","article-title":"Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes","volume":"108","author":"Kehat","year":"2001","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.bbadis.2017.12.025_bb0350","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1056\/NEJM198908103210601","article-title":"Early metabolic defects in persons at increased risk for non-insulin-dependent diabetes mellitus","volume":"321","author":"Eriksson","year":"1989","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.bbadis.2017.12.025_bb0355","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1056\/NEJM199001253220403","article-title":"Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy","volume":"322","author":"Shulman","year":"1990","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"10.1016\/j.bbadis.2017.12.025_bb0360","doi-asserted-by":"crossref","first-page":"C1549","DOI":"10.1152\/ajpcell.00334.2009","article-title":"Differential regulation of cardiac glucose and fatty acid uptake by endosomal pH and actin filaments","volume":"298","author":"Steinbusch","year":"2010","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"4","key":"10.1016\/j.bbadis.2017.12.025_bb0365","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1530\/REP-14-0633","article-title":"Distinct profiles of human embryonic stem cell metabolism and mitochondria identified by oxygen","volume":"150","author":"Lees","year":"2015","journal-title":"Reproduction"},{"issue":"1","key":"10.1016\/j.bbadis.2017.12.025_bb0370","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1093\/toxsci\/kfs233","article-title":"Characterization of human-induced pluripotent stem cell-derived cardiomyocytes: bioenergetics and utilization in safety screening","volume":"130","author":"Rana","year":"2012","journal-title":"Toxicol. Sci."},{"issue":"20","key":"10.1016\/j.bbadis.2017.12.025_bb0375","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1161\/CIRCULATIONAHA.114.014998","article-title":"Mechanical stress conditioning and electrical stimulation promote contractility and force maturation of induced pluripotent stem cell-derived human cardiac tissue","volume":"134","author":"Ruan","year":"2016","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.bbadis.2017.12.025_bb0380","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1634\/stemcells.2006-0466","article-title":"Developmental changes in cardiomyocytes differentiated from human embryonic stem cells: a molecular and electrophysiological approach","volume":"25","author":"Sartiani","year":"2007","journal-title":"Stem Cells"},{"issue":"23","key":"10.1016\/j.bbadis.2017.12.025_bb0385","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1016\/0024-3205(91)90310-8","article-title":"Highly insulin-responsive isolated rat heart muscle cells yielded by a modified isolation method","volume":"49","author":"Fischer","year":"1991","journal-title":"Life Sci."},{"issue":"4","key":"10.1016\/j.bbadis.2017.12.025_bb0390","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physiolgenomics.00118.2011","article-title":"Global transcriptional profiling reveals similarities and differences between human stem cell-derived cardiomyocyte clusters and heart tissue","volume":"44","author":"Synnergren","year":"2012","journal-title":"Physiol. Genomics"},{"issue":"21","key":"10.1016\/j.bbadis.2017.12.025_bb0395","doi-asserted-by":"crossref","first-page":"5279","DOI":"10.1113\/jphysiol.2013.256495","article-title":"Calcium signalling of human pluripotent stem cell-derived cardiomyocytes","volume":"591","author":"Li","year":"2013","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbadis.2017.12.025_bb0400","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.biomaterials.2015.01.067","article-title":"Functional maturation of human pluripotent stem cell derived cardiomyocytes in vitro\u2013correlation between contraction force and electrophysiology","volume":"51","author":"Ribeiro","year":"2015","journal-title":"Biomaterials"},{"issue":"17","key":"10.1016\/j.bbadis.2017.12.025_bb0405","doi-asserted-by":"crossref","first-page":"7105","DOI":"10.1074\/jbc.M116.767384","article-title":"2-Arachidonoylglycerol ameliorates inflammatory stress-induced insulin resistance in cardiomyocytes","volume":"292","author":"Chanda","year":"2017","journal-title":"J. Biol. Chem."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443917304799?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443917304799?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T07:38:31Z","timestamp":1565336311000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443917304799"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":81,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["S0925443917304799"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2017.12.025","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human embryonic stem cell-derived cardiomyocytes as an in vitro model to study cardiac insulin resistance","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2017.12.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V.","name":"copyright","label":"Copyright"}]}}