{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:54:44Z","timestamp":1790218484004,"version":"4.1.0"},"reference-count":96,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570225"],"award-info":[{"award-number":["81570225"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81521001"],"award-info":[{"award-number":["81521001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.bbadis.2018.03.016","type":"journal-article","created":{"date-parts":[[2018,3,17]],"date-time":"2018-03-17T01:08:39Z","timestamp":1521248919000},"page":"2003-2009","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"special_numbering":"PA","title":["Role of autophagy and regulatory mechanisms in alcoholic cardiomyopathy"],"prefix":"10.1016","volume":"1864","author":[{"given":"Shuyi","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2018.03.016_bb0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejim.2017.06.014","article-title":"Alcoholic cardiomyopathy: what is known and what is not known","volume":"43","author":"Mirijello","year":"2017","journal-title":"European Journal of Internal Medicine"},{"key":"10.1016\/j.bbadis.2018.03.016_bb0010","doi-asserted-by":"crossref","first-page":"771","DOI":"10.4330\/wjc.v6.i8.771","article-title":"Alcoholic cardiomyopathy","volume":"6","author":"Guzzo-Merello","year":"2014","journal-title":"World J. Cardiol."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0015","first-page":"219","article-title":"Alcohol's effects on the cardiovascular system","volume":"38","author":"Piano","year":"2017","journal-title":"Alcohol Research: Current Reviews"},{"key":"10.1016\/j.bbadis.2018.03.016_bb0020","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1161\/CIRCULATIONAHA.117.030387","article-title":"Wine and cardiovascular health: a comprehensive review","volume":"136","author":"Haseeb","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.bbadis.2018.03.016_bb0025","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.tcm.2017.06.002","article-title":"Cardiovascular effects of alcohol consumption","volume":"27","author":"Rehm","year":"2017","journal-title":"Trends in Cardiovascular Medicine"},{"key":"10.1016\/j.bbadis.2018.03.016_bb0030","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1093\/alcalc\/agt007","article-title":"Effects of wine, alcohol and polyphenols on cardiovascular disease risk factors: evidences from human studies","volume":"48","author":"Chiva-Blanch","year":"2013","journal-title":"Alcohol Alcohol."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0035","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3109\/10253890.2013.777833","article-title":"Habitual alcohol consumption is associated with lower cardiovascular stress responses \u2014 a novel explanation for the known cardiovascular benefits of alcohol?","volume":"16","author":"Jones","year":"2013","journal-title":"Stress"},{"key":"10.1016\/j.bbadis.2018.03.016_bb0040","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1002\/cphy.c140046","article-title":"Alcohol effects on cardiac function","volume":"5","author":"Gardner","year":"2015","journal-title":"Comprehensive Physiology"},{"key":"10.1016\/j.bbadis.2018.03.016_bb0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4077\/CJP.2016.BAE364","article-title":"A heart too drunk to drive; AV block following acute alcohol intoxication","volume":"59","author":"van Stigt","year":"2016","journal-title":"The Chinese Journal of Physiology"},{"key":"10.1016\/j.bbadis.2018.03.016_bb0050","first-page":"1099","article-title":"Advances and new concepts in alcohol-induced organelle stress, unfolded protein responses and organ damage","volume":"5","author":"Ji","year":"2015","journal-title":"Biomol. Ther."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0055","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.neuroscience.2015.07.012","article-title":"Alcohol hangover induces mitochondrial dysfunction and free radical production in mouse cerebellum","volume":"304","author":"Karadayian","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbadis.2018.03.016_bb0060","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s12012-014-9252-4","article-title":"Alcoholic cardiomyopathy: pathophysiologic insights","volume":"14","author":"Piano","year":"2014","journal-title":"Cardiovasc. Toxicol."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0065","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1111\/acer.13405","article-title":"Alcoholic cardiomyopathy: disrupted protein balance and impaired cardiomyocyte contractility","volume":"41","author":"Steiner","year":"2017","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0070","doi-asserted-by":"crossref","first-page":"3","DOI":"10.17116\/sudmed20165913-6","article-title":"The morphological changes in the myocardial tissue after sudden cardiac death from alcoholic cardiomyopathy","volume":"59","author":"Sokolova","year":"2016","journal-title":"Sud. Med. Ekspert."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0075","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1111\/acer.12239","article-title":"Alcohol modulation of cardiac matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs favors collagen accumulation","volume":"38","author":"El Hajj","year":"2014","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0080","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.mayocp.2013.11.005","article-title":"Alcohol and cardiovascular health: the dose makes the poison\u2026or the remedy","volume":"89","author":"O'Keefe","year":"2014","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0085","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/joim.12390","article-title":"Alcohol and cardiovascular diseases: where do we stand today?","volume":"278","author":"Klatsky","year":"2015","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0090","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1111\/j.1530-0277.2007.00404.x","article-title":"Up-regulation of myocardial L-type Ca2+ channel in chronic alcoholic subjects without cardiomyopathy","volume":"31","author":"Fatjo","year":"2007","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"6","key":"10.1016\/j.bbadis.2018.03.016_bb0095","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.yjmcc.2008.02.276","article-title":"Cardiac overexpression of alcohol dehydrogenase exacerbates chronic ethanol ingestion-induced myocardial dysfunction and hypertrophy: role of insulin signaling and ER stress","volume":"44","author":"Li","year":"2008","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0100","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1161\/CIRCULATIONAHA.108.823799","article-title":"Transgenic overexpression of aldehyde dehydrogenase-2 rescues chronic alcohol intake-induced myocardial hypertrophy and contractile dysfunction","volume":"119","author":"Doser","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.bbadis.2018.03.016_bb0105","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.pharmthera.2011.05.008","article-title":"ALDH2 in alcoholic heart diseases: molecular mechanism and clinical implications","volume":"132","author":"Zhang","year":"2011","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0110","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.biocel.2017.06.009","article-title":"Etiology of alcoholic cardiomyopathy: mitochondria, oxidative stress and apoptosis","volume":"89","author":"Steiner","year":"2017","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0115","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1080\/14728222.2018.1439922","article-title":"The potential of aldehyde dehydrogenase 2 as a therapeutic target in cardiovascular disease","volume":"22","author":"Munzel","year":"2018","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.bbadis.2018.03.016_bb0120","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1093\/alcalc\/agx049","article-title":"Genetic polymorphisms of alcohol metabolizing enzymes and alcohol consumption are associated with asymptomatic cardiac remodeling and subclinical systolic dysfunction in large community-dwelling Asians","volume":"52","author":"Hung","year":"2017","journal-title":"Alcohol Alcohol."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0125","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.amjmed.2017.02.041","article-title":"Alcohol intake more than doubles the risk of early cardiovascular events in young hypertensive smokers","volume":"130","author":"Palatini","year":"2017","journal-title":"Am. J. Med."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0130","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1111\/acer.12363","article-title":"Oxidative stress and autonomic dysregulation contribute to the acute time-dependent myocardial depressant effect of ethanol in conscious female rats","volume":"38","author":"Ibrahim","year":"2014","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0135","doi-asserted-by":"crossref","DOI":"10.1038\/srep32554","article-title":"NOX2 amplifies acetaldehyde-mediated cardiomyocyte mitochondrial dysfunction in alcoholic cardiomyopathy","volume":"6","author":"Brandt","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0140","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1007\/s00059-016-4459-8","article-title":"Enzymes and signal pathways in the pathogenesis of alcoholic cardiomyopathy","volume":"41","author":"Leibing","year":"2016","journal-title":"Herz"},{"key":"10.1016\/j.bbadis.2018.03.016_bb0145","doi-asserted-by":"crossref","first-page":"D601","DOI":"10.2741\/A457","article-title":"The role of alcohol in the oxidant antioxidant balance in heart","volume":"4","author":"McDonough","year":"1999","journal-title":"Front. Biosci."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0150","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1016\/S0891-5849(01)00744-4","article-title":"Distribution of ethanol-induced protein adducts in vivo: relationship to tissue injury","volume":"31","author":"Niemela","year":"2001","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0155","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.yjmcc.2013.02.005","article-title":"Chronic ethanol consumption increases cardiomyocyte fatty acid uptake and decreases ventricular contractile function in C57BL\/6J mice","volume":"59","author":"Hu","year":"2013","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0160","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/10408360290795529","article-title":"Effect of alcohol on lipids and lipoproteins in relation to atherosclerosis","volume":"39","author":"Hannuksela","year":"2002","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0165","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s10517-017-3865-0","article-title":"Alcoholic cardiomyopathy: translation model","volume":"163","author":"Kryzhanovskii","year":"2017","journal-title":"Bull. Exp. Biol. Med."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0170","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.yjmcc.2005.11.006","article-title":"Attenuation of acetaldehyde-induced cell injury by overexpression of aldehyde dehydrogenase-2 (ALDH2) transgene in human cardiac myocytes: role of MAP kinase signaling","volume":"40","author":"Li","year":"2006","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0175","doi-asserted-by":"crossref","first-page":"H121","DOI":"10.1152\/ajpheart.00520.2007","article-title":"Cellular redox state protects acetaldehyde-induced alteration in cardiomyocyte function by modifying Ca2+ release from sarcoplasmic reticulum","volume":"294","author":"Oba","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0180","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.bbadis.2012.08.014","article-title":"Inhibition of CYP2E1 attenuates chronic alcohol intake-induced myocardial contractile dysfunction and apoptosis","volume":"1832","author":"Zhang","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2018.03.016_bb0185","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.athoracsur.2016.11.075","article-title":"Effects of alcohol on postoperative adhesion formation in ischemic myocardium and pericardium","volume":"104","author":"Elmadhun","year":"2017","journal-title":"Ann. Thorac. Surg."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0190","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17101651","article-title":"New treatment strategies for alcohol-induced heart damage","volume":"17","author":"Fernandez-Sola","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0195","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1111\/acer.13421","article-title":"Evidence of altered mitochondrial protein expression after chronic ethanol consumption in the aged estrogen-deficient female rat heart","volume":"41","author":"Garvin","year":"2017","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0200","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1111\/j.1582-4934.2011.01347.x","article-title":"mTOR-STAT3-notch signalling contributes to ALDH2-induced protection against cardiac contractile dysfunction and autophagy under alcoholism","volume":"16","author":"Ge","year":"2012","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0205","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1016\/j.jacc.2009.04.100","article-title":"Aldehyde dehydrogenase 2 ameliorates acute cardiac toxicity of ethanol: role of protein phosphatase and forkhead transcription factor","volume":"54","author":"Ma","year":"2009","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0210","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.yjmcc.2010.03.017","article-title":"Aldehyde dehydrogenase 2 knockout accentuates ethanol-induced cardiac depression: role of protein phosphatases","volume":"49","author":"Ma","year":"2010","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0215","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1111\/j.1530-0277.2001.tb02294.x","article-title":"Cardioprotective effect of propranolol from alcohol-induced heart muscle damage as assessed by plasma cardiac troponin-t","volume":"25","author":"Patel","year":"2001","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0220","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S1566-0702(02)00206-0","article-title":"Effects of aldehyde dehydrogenase-2 genotype on cardiovascular and endocrine responses to alcohol in young Japanese subjects","volume":"102","author":"Nishimura","year":"2002","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0225","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/em.21824","article-title":"Acetaldehyde and the genome: beyond nuclear DNA adducts and carcinogenesis","volume":"55","author":"Brooks","year":"2014","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0230","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.redox.2017.04.020","article-title":"Mitochondrial ROS induced by chronic ethanol exposure promote hyper-activation of the NLRP3 inflammasome","volume":"12","author":"Hoyt","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0235","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0891-5849(01)00769-9","article-title":"Contribution of mitochondria to oxidative stress associated with alcoholic liver disease","volume":"32","author":"Bailey","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0240","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s12192-016-0760-y","article-title":"Increased expression of microRNA-378a-5p in acute ethanol exposure of rat cardiomyocytes","volume":"22","author":"Wang","year":"2017","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.bbadis.2018.03.016_bb0245","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0147322","article-title":"Alcohol dehydrogenase protects against endoplasmic reticulum stress-induced myocardial contractile dysfunction via attenuation of oxidative stress and autophagy: role of PTEN-Akt-mTOR signaling","volume":"11","author":"Pang","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2018.03.016_bb0250","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1093\/cvr\/cvs127","article-title":"Deficiency in AMPK attenuates ethanol-induced cardiac contractile dysfunction through inhibition of autophagosome formation","volume":"94","author":"Guo","year":"2012","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0255","doi-asserted-by":"crossref","first-page":"4874","DOI":"10.2174\/1381612811319270010","article-title":"ULK1 plays a critical role in AMPK-mediated myocardial autophagy and contractile dysfunction following acute alcohol challenge","volume":"19","author":"Kandadi","year":"2013","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0260","doi-asserted-by":"crossref","first-page":"22A","DOI":"10.1016\/S0735-1097(86)80025-0","article-title":"Ultrastructural and histochemical observations in human and experimental alcoholic cardiomyopathy","volume":"8","author":"Tsiplenkova","year":"1986","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0265","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/0002-8703(65)90450-3","article-title":"Alcoholic cardiomyopathy; an electron microscopic study","volume":"69","author":"Hibbs","year":"1965","journal-title":"Am. Heart J."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0270","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1111\/j.1530-0277.2010.01200.x","article-title":"Impact of chronic alcohol ingestion on cardiac muscle protein expression","volume":"34","author":"Fogle","year":"2010","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0275","doi-asserted-by":"crossref","first-page":"R23","DOI":"10.1152\/ajpregu.00414.2013","article-title":"Chronic alcohol consumption disrupts myocardial protein balance and function in aged, but not adult, female F344 rats","volume":"306","author":"Lang","year":"2014","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0280","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.redox.2014.10.006","article-title":"Ethanol-induced oxidant stress modulates hepatic autophagy and proteasome activity","volume":"3","author":"Donohue","year":"2014","journal-title":"Redox Biol."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0285","doi-asserted-by":"crossref","first-page":"E699","DOI":"10.1152\/ajpendo.00006.2015","article-title":"Dysregulation of skeletal muscle protein metabolism by alcohol","volume":"308","author":"Steiner","year":"2015","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0290","first-page":"1781","article-title":"Hydrogen sulfide alleviates myocardial fibrosis in mice with alcoholic cardiomyopathy by downregulating autophagy","volume":"40","author":"Liang","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0295","doi-asserted-by":"crossref","first-page":"593","DOI":"10.4161\/auto.18997","article-title":"Facilitated ethanol metabolism promotes cardiomyocyte contractile dysfunction through autophagy in murine hearts","volume":"8","author":"Guo","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.bbadis.2018.03.016_bb0300","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1016\/j.freeradbiomed.2011.08.002","article-title":"AMP-dependent kinase and autophagic flux are involved in aldehyde dehydrogenase-2-induced protection against cardiac toxicity of ethanol","volume":"51","author":"Ge","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0305","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1002\/jcp.25934","article-title":"Acute ethanol exposure-induced autophagy-mediated cardiac injury via activation of the ROS-JNK-Bcl-2 pathway","volume":"233","author":"Zhu","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0310","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/nrd.2017.22","article-title":"Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles","volume":"16","author":"Galluzzi","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0315","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/nrcardio.2017.35","article-title":"Myocardial stress and autophagy: mechanisms and potential therapies","volume":"14","author":"Delbridge","year":"2017","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0320","doi-asserted-by":"crossref","first-page":"242","DOI":"10.3109\/15563650.2012.672743","article-title":"The acute effects of ethanol and acetaldehyde on physiological responses after ethanol ingestion in young healthy men with different ALDH2 genotypes","volume":"50","author":"Bae","year":"2012","journal-title":"Clin. Toxicol. (Phila)"},{"key":"10.1016\/j.bbadis.2018.03.016_bb0325","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/S0891-5849(00)00226-4","article-title":"Role of reactive aldehyde in cardiovascular diseases","volume":"28","author":"Uchida","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0330","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1139\/y83-001","article-title":"Pharmacology of acetaldehyde","volume":"61","author":"Brien","year":"1983","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0335","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1093\/carcin\/18.4.627","article-title":"Detection of DNA adducts of acetaldehyde in peripheral white blood cells of alcohol abusers","volume":"18","author":"Fang","year":"1997","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.bbadis.2018.03.016_bb0340","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1021\/tx970169z","article-title":"Stable acetaldehyde \u2014 protein adducts as biomarkers of alcohol exposure","volume":"11","author":"Conduah Birt","year":"1998","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0345","doi-asserted-by":"crossref","first-page":"939","DOI":"10.33549\/physiolres.932985","article-title":"Acetaldehyde at clinically relevant concentrations inhibits inward rectifier potassium current I(K1) in rat ventricular myocytes","volume":"64","author":"Bebarova","year":"2015","journal-title":"Physiol. Res."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0350","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0741-8329(89)90033-5","article-title":"Effects of acetaldehyde on the automaticity of the guinea pig sinus node","volume":"6","author":"Brown","year":"1989","journal-title":"Alcohol"},{"key":"10.1016\/j.bbadis.2018.03.016_bb0355","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0741-8329(90)90057-J","article-title":"Effects of acetaldehyde on membrane potentials of sinus node pacemaker fibers","volume":"7","author":"Brown","year":"1990","journal-title":"Alcohol"},{"key":"10.1016\/j.bbadis.2018.03.016_bb0360","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.humpath.2006.03.022","article-title":"Evidence of apoptosis in alcoholic cardiomyopathy","volume":"37","author":"Fernandez-Sola","year":"2006","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0365","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1093\/alcalc\/37.3.222","article-title":"Combined calcium carbimide and ethanol treatment induces high blood acetaldehyde levels, myocardial apoptosis and altered expression of apoptosis-regulating genes in rat","volume":"37","author":"Jankala","year":"2002","journal-title":"Alcohol Alcohol."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0370","first-page":"781","article-title":"ALDH2 modulates autophagy flux to regulate acetaldehyde-mediated toxicity thresholds","volume":"6","author":"Tanaka","year":"2016","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0375","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.jhep.2014.10.009","article-title":"Aldehyde dedydrogenase-2 plays a beneficial role in ameliorating chronic alcohol-induced hepatic steatosis and inflammation through regulation of autophagy","volume":"62","author":"Guo","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0380","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1093\/toxsci\/kfx140","article-title":"From the cover: alcohol inhibition of the enzymatic activity of glyceraldehyde 3-phosphate dehydrogenase impairs cardiac glucose utilization, contributing to alcoholic cardiomyopathy","volume":"159","author":"Yan","year":"2017","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0385","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/BF01907225","article-title":"Alcohol-induced congestive cardiomyopathy in adult turkeys: effects on myocardial antioxidant defence systems","volume":"82","author":"Edes","year":"1987","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0390","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S0022-2828(03)00080-4","article-title":"Cardiac-specific overexpression of catalase rescues ventricular myocytes from ethanol-induced cardiac contractile defect","volume":"35","author":"Zhang","year":"2003","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0395","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0014-5793(94)00549-4","article-title":"Free radical activation of acetaldehyde and its role in protein alkylation","volume":"348","author":"Albano","year":"1994","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0400","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/BF00745024","article-title":"Mitochondrial chemiluminescence elicited by acetaldehyde","volume":"14","author":"Boh","year":"1982","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0405","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/0741-8329(91)90588-N","article-title":"Electron spin resonance study of free radicals produced from ethanol and acetaldehyde after exposure to a Fenton system or to brain and liver microsomes","volume":"8","author":"Gonthier","year":"1991","journal-title":"Alcohol"},{"key":"10.1016\/j.bbadis.2018.03.016_bb0410","first-page":"195","article-title":"Role of acetaldehyde and xanthine oxidase in ethanol-induced oxidative stress","volume":"51","author":"Oei","year":"1986","journal-title":"Res. Commun. Chem. Pathol. Pharmacol."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0415","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/0024-3205(90)90553-4","article-title":"DNA cleavage during ethanol metabolism: role of superoxide radicals and catalytic iron","volume":"47","author":"Rajasinghe","year":"1990","journal-title":"Life Sci."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0420","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.molcel.2008.06.001","article-title":"JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy","volume":"30","author":"Wei","year":"2008","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbadis.2018.03.016_bb0425","doi-asserted-by":"crossref","first-page":"754","DOI":"10.4161\/auto.6360","article-title":"Induction of macroautophagy by exogenously introduced calcium","volume":"4","author":"Gao","year":"2008","journal-title":"Autophagy"},{"key":"10.1016\/j.bbadis.2018.03.016_bb0430","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.4161\/15548627.2014.981916","article-title":"Autophagy and ethanol neurotoxicity","volume":"10","author":"Luo","year":"2014","journal-title":"Autophagy"},{"key":"10.1016\/j.bbadis.2018.03.016_bb0435","article-title":"Noncoding RNA profiles in tobacco- and alcohol-associated diseases","volume":"8","author":"Soares do Amaral","year":"2016","journal-title":"Gene"},{"key":"10.1016\/j.bbadis.2018.03.016_bb0440","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1159\/000370028","article-title":"Investigation of microRNA expression profiles associated with human alcoholic cardiomyopathy","volume":"130","author":"Jing","year":"2015","journal-title":"Cardiology"},{"key":"10.1016\/j.bbadis.2018.03.016_bb0445","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.3892\/or.2017.5838","article-title":"Clinical significance of miR-138 in patients with malignant melanoma through targeting of PDK1 in the PI3K\/AKT autophagy signaling pathway","volume":"38","author":"Meng","year":"2017","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0450","doi-asserted-by":"crossref","first-page":"3244","DOI":"10.3892\/or.2017.5619","article-title":"miR-138 suppresses the proliferation, metastasis and autophagy of non-small cell lung cancer by targeting Sirt1","volume":"37","author":"Ye","year":"2017","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0455","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/s41556-018-0037-z","article-title":"Cargo recognition and degradation by selective autophagy","volume":"20","author":"Gatica","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0460","doi-asserted-by":"crossref","first-page":"G324","DOI":"10.1152\/ajpgi.00108.2015","article-title":"Parkin regulates mitophagy and mitochondrial function to protect against alcohol-induced liver injury and steatosis in mice","volume":"309","author":"Williams","year":"2015","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0465","doi-asserted-by":"crossref","DOI":"10.3390\/nu8010027","article-title":"Quercetin attenuates chronic ethanol-induced hepatic mitochondrial damage through enhanced mitophagy","volume":"8","author":"Yu","year":"2016","journal-title":"Nutrients"},{"key":"10.1016\/j.bbadis.2018.03.016_bb0470","first-page":"1143","article-title":"Ethanol-induced mitophagy in liver is associated with activation of the PINK1-Parkin pathway triggered by oxidative DNA damage","volume":"31","author":"Eid","year":"2016","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.bbadis.2018.03.016_bb0475","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.alcohol.2007.05.004","article-title":"Is the cardioprotective effect of alcohol real?","volume":"41","author":"Fuchs","year":"2007","journal-title":"Alcohol"},{"key":"10.1016\/j.bbadis.2018.03.016_bb0480","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.3892\/etm.2017.4901","article-title":"Therapeutic effects of rapamycin on alcoholic cardiomyopathy","volume":"14","author":"Tu","year":"2017","journal-title":"Experimental and Therapeutic Medicine"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443918300966?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443918300966?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T02:44:50Z","timestamp":1719888290000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443918300966"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":96,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["S0925443918300966"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2018.03.016","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of autophagy and regulatory mechanisms in alcoholic cardiomyopathy","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2018.03.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V.","name":"copyright","label":"Copyright"}]}}