{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:32:54Z","timestamp":1787877174528,"version":"build-2784847793"},"reference-count":83,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004396","name":"Thailand Research Fund","doi-asserted-by":"publisher","award":["RSA6080015"],"award-info":[{"award-number":["RSA6080015"]}],"id":[{"id":"10.13039\/501100004396","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002842","name":"Chiang Mai University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002842","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Graduate Research Scholarships for the Fiscal Year 2560 Graduate School Chiang Mai University"},{"name":"Center for Research and Development of Natural Products for Health"},{"name":"National Science and Technology Development Agency of Thailand"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.bbadis.2018.03.017","type":"journal-article","created":{"date-parts":[[2018,3,20]],"date-time":"2018-03-20T23:18:14Z","timestamp":1521587894000},"page":"2021-2033","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"PA","title":["Renal outcomes with sodium glucose cotransporter 2 (SGLT2) inhibitor, dapagliflozin, in obese insulin-resistant model"],"prefix":"10.1016","volume":"1864","author":[{"given":"Krit","family":"Jaikumkao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anchalee","family":"Pongchaidecha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuttawud","family":"Chueakula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laongdao","family":"Thongnak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keerati","family":"Wanchai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varanuj","family":"Chatsudthipong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nipon","family":"Chattipakorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anusorn","family":"Lungkaphin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2018.03.017_bb0005","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1111\/j.1467-789X.2010.00810.x","article-title":"The levelling off of the obesity epidemic since the year 1999\u2013a review of evidence and perspectives","volume":"11","author":"Rokholm","year":"2010","journal-title":"Obes. Rev."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0010","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1001\/2013.jamainternmed.85","article-title":"Body mass index in 1.2 million adolescents and risk for end-stage renal disease","volume":"172","author":"Vivante","year":"2012","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0015","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1007\/s11255-014-0656-7","article-title":"Perirenal fat associated with microalbuminuria in obese rats","volume":"46","author":"Hou","year":"2014","journal-title":"Int. Urol. Nephrol."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0020","doi-asserted-by":"crossref","first-page":"S114","DOI":"10.1097\/01.ASN.0000070156.78824.C7","article-title":"National kidney disease education program","volume":"14","author":"Hostetter","year":"2003","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0025","article-title":"Interaction of obesity and central obesity on elevated urinary albumin-to-creatinine ratio","volume":"9","author":"Du","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2018.03.017_bb0030","doi-asserted-by":"crossref","first-page":"R188","DOI":"10.1152\/ajpregu.00018.2004","article-title":"Decreased epoxygenase and increased epoxide hydrolase expression in the mesenteric artery of obese Zucker rats","volume":"288","author":"Zhao","year":"2005","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0035","doi-asserted-by":"crossref","first-page":"E1047","DOI":"10.1152\/ajpendo.00666.2010","article-title":"High-fat diet induces an initial adaptation of mitochondrial bioenergetics in the kidney despite evident oxidative stress and mitochondrial ROS production","volume":"300","author":"Ruggiero","year":"2011","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0040","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1172\/JCI21625","article-title":"Increased oxidative stress in obesity and its impact on metabolic syndrome","volume":"114","author":"Furukawa","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0045","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.3390\/nu6072619","article-title":"Resveratrol increases nephrin and podocin expression and alleviates renal damage in rats fed a high-fat diet","volume":"6","author":"Pan","year":"2014","journal-title":"Nutrients"},{"key":"10.1016\/j.bbadis.2018.03.017_bb0050","doi-asserted-by":"crossref","first-page":"39616","DOI":"10.1074\/jbc.M502412200","article-title":"Nox4 NAD(P)H oxidase mediates hypertrophy and fibronectin expression in the diabetic kidney","volume":"280","author":"Gorin","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0055","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ejphar.2017.04.026","article-title":"The superoxide dismutase mimetic tempol blunts diabetes-induced upregulation of NADPH oxidase and endoplasmic reticulum stress in a rat model of diabetic nephropathy","volume":"807","author":"De Blasio","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0060","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1161\/01.HYP.0000255636.11931.a2","article-title":"Podocyte as the target for aldosterone: roles of oxidative stress and Sgk1","volume":"49","author":"Shibata","year":"2007","journal-title":"Hypertension"},{"key":"10.1016\/j.bbadis.2018.03.017_bb0065","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1007\/s00467-011-1785-1","article-title":"Glomerular basement membrane composition and the filtration barrier","volume":"26","author":"Miner","year":"2011","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0070","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1681\/ASN.2013020173","article-title":"Urine podocyte mRNAs, proteinuria, and progression in human glomerular diseases","volume":"24","author":"Wickman","year":"2013","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0075","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.freeradbiomed.2017.11.021","article-title":"Diacerein alleviates kidney injury through attenuating inflammation and oxidative stress in obese insulin-resistant rats","volume":"115","author":"Chueakula","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0080","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1210\/endo.136.5.7536658","article-title":"Expression of insulin-like growth factor binding proteins in the rat kidney: effects of long-term diabetes","volume":"136","author":"Landau","year":"1995","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbadis.2018.03.017_bb0085","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1097\/01.ASN.0000135055.61833.A8","article-title":"Interactions between angiotensin II and NF-kappaB-dependent pathways in modulating macrophage infiltration in experimental diabetic nephropathy","volume":"15","author":"Lee","year":"2004","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0090","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1182\/blood-2013-09-512749","article-title":"Oxidative stress in angiogenesis and vascular disease","volume":"123","author":"Kim","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.bbadis.2018.03.017_bb0095","doi-asserted-by":"crossref","first-page":"F182","DOI":"10.1152\/ajprenal.00548.2012","article-title":"Insulin directly stimulates VEGF-A production in the glomerular podocyte","volume":"305","author":"Hale","year":"2013","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0100","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1161\/HYPERTENSIONAHA.110.162339","article-title":"Oxidative stress causes renal angiotensin II type 1 receptor upregulation, Na+\/H+ exchanger 3 overstimulation, and hypertension","volume":"57","author":"Banday","year":"2011","journal-title":"Hypertension"},{"key":"10.1016\/j.bbadis.2018.03.017_bb0105","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3109\/10641963.2014.943402","article-title":"Vascular oxidative stress upregulates angiotensin II type I receptors via mechanisms involving nuclear factor kappa B","volume":"36","author":"Bhatt","year":"2014","journal-title":"Clin. Exp. Hypertens."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0110","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1161\/HYPERTENSIONAHA.108.121954","article-title":"Mineralocorticoid receptor antagonism attenuates vascular apoptosis and injury via rescuing protein kinase B activation","volume":"53","author":"Wei","year":"2009","journal-title":"Hypertension"},{"key":"10.1016\/j.bbadis.2018.03.017_bb0115","doi-asserted-by":"crossref","first-page":"R561","DOI":"10.1152\/ajpregu.00392.2011","article-title":"Activation of the central melanocortin system contributes to the increased arterial pressure in obese Zucker rats","volume":"302","author":"do Carmo","year":"2012","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0120","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1128\/MCB.06410-11","article-title":"Angiotensin II induces epithelial-to-mesenchymal transition in renal epithelial cells through reactive oxygen species\/Src\/caveolin-mediated activation of an epidermal growth factor receptor-extracellular signal-regulated kinase signaling pathway","volume":"32","author":"Chen","year":"2012","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0125","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1139\/cjpp-2015-0468","article-title":"Pinocembrin attenuates gentamicin-induced nephrotoxicity in rats","volume":"94","author":"Promsan","year":"2016","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0130","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1113\/EP085571","article-title":"Atorvastatin improves renal organic anion transporter 3 and renal function in gentamicin-induced nephrotoxicity in rats","volume":"101","author":"Jaikumkao","year":"2016","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0135","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.bcp.2004.12.004","article-title":"Restored expression and activity of organic ion transporters rOAT1, rOAT3 and rOCT2 after hyperuricemia in the rat kidney","volume":"69","author":"Habu","year":"2005","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0140","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1681\/ASN.V134866","article-title":"Gene expression levels and immunolocalization of organic ion transporters in the human kidney","volume":"13","author":"Motohashi","year":"2002","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0145","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1152\/physrev.00025.2013","article-title":"The organic anion transporter (OAT) family: a systems biology perspective","volume":"95","author":"Nigam","year":"2015","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0150","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1681\/ASN.2008020180","article-title":"Organic anion transporter 3 contributes to the regulation of blood pressure","volume":"19","author":"Vallon","year":"2008","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0155","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.pharmthera.2009.09.008","article-title":"Pathophysiological regulation of renal SLC22A organic ion transporters in acute kidney injury: pharmacological and toxicological implications","volume":"125","author":"Saito","year":"2010","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0160","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0096236","article-title":"Impaired insulin signaling affects renal organic anion transporter 3 (Oat3) function in streptozotocin-induced diabetic rats","volume":"9","author":"Lungkaphin","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2018.03.017_bb0165","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.cmet.2014.03.008","article-title":"The furan fatty acid metabolite CMPF is elevated in diabetes and induces beta cell dysfunction","volume":"19","author":"Prentice","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0170","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-13206-5","article-title":"The additive effects of atorvastatin and insulin on renal function and renal organic anion transporter 3 function in diabetic rats","volume":"7","author":"Thongnak","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0175","doi-asserted-by":"crossref","first-page":"15789","DOI":"10.1074\/jbc.M117.796516","article-title":"The drug transporter OAT3 (SLC22A8) and endogenous metabolite communication via the gut-liver-kidney axis","volume":"292","author":"Bush","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0180","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1111\/dom.12127","article-title":"Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes","volume":"15","author":"Lambers Heerspink","year":"2013","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0185","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.metabol.2015.10.010","article-title":"The SGLT2 inhibitor empagliflozin improves insulin sensitivity in db\/db mice both as monotherapy and in combination with linagliptin","volume":"65","author":"Kern","year":"2016","journal-title":"Metabolism"},{"key":"10.1016\/j.bbadis.2018.03.017_bb0190","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/1753-0407.12494","article-title":"Beneficial effects of sodium-glucose cotransporter 2 inhibitors for preservation of pancreatic beta-cell function and reduction of insulin resistance","volume":"9","author":"Kaneto","year":"2017","journal-title":"J. Diabetes"},{"key":"10.1016\/j.bbadis.2018.03.017_bb0195","first-page":"191","article-title":"Highly selective inhibitor of SGLT2 blocks proinflammatory and proapoptotic effects of glucose overload on proximal tubular cells partly by suppressing oxidative stress generation","volume":"48","author":"Ishibashi","year":"2016","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0200","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0100777","article-title":"Long-term treatment with the sodium glucose cotransporter 2 inhibitor, dapagliflozin, ameliorates glucose homeostasis and diabetic nephropathy in db\/db mice","volume":"9","author":"Terami","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2018.03.017_bb0205","doi-asserted-by":"crossref","first-page":"F317","DOI":"10.1152\/ajprenal.00145.2014","article-title":"The SGLT2 inhibitor empagliflozin ameliorates early features of diabetic nephropathy in BTBR ob\/ob type 2 diabetic mice with and without hypertension","volume":"307","author":"Gembardt","year":"2014","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0210","doi-asserted-by":"crossref","first-page":"F194","DOI":"10.1152\/ajprenal.00520.2013","article-title":"SGLT2 inhibitor empagliflozin reduces renal growth and albuminuria in proportion to hyperglycemia and prevents glomerular hyperfiltration in diabetic Akita mice","volume":"306","author":"Vallon","year":"2014","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0215","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1161\/CIRCULATIONAHA.113.005081","article-title":"Renal hemodynamic effect of sodium-glucose cotransporter 2 inhibition in patients with type 1 diabetes mellitus","volume":"129","author":"Cherney","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.bbadis.2018.03.017_bb0220","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.lfs.2011.08.011","article-title":"Effects of estrogen in preventing neuronal insulin resistance in hippocampus of obese rats are different between genders","volume":"89","author":"Pratchayasakul","year":"2011","journal-title":"Life Sci."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0225","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0165703","article-title":"Effect of sodium-glucose co-transporter 2 inhibitor, dapagliflozin, on renal renin-angiotensin system in an animal model of type 2 diabetes","volume":"11","author":"Shin","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2018.03.017_bb0230","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0102374","article-title":"Combined vildagliptin and metformin exert better cardioprotection than monotherapy against ischemia-reperfusion injury in obese-insulin resistant rats","volume":"9","author":"Apaijai","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2018.03.017_bb0235","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.nut.2009.02.001","article-title":"Effects of curcuminoid supplement on cardiac autonomic status in high-fat-induced obese rats","volume":"25","author":"Pongchaidecha","year":"2009","journal-title":"Nutrition"},{"key":"10.1016\/j.bbadis.2018.03.017_bb0240","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1016\/j.phymed.2016.10.014","article-title":"Riceberry bran extract prevents renal dysfunction and impaired renal organic anion transporter 3 (Oat3) function by modulating the PKC\/Nrf2 pathway in gentamicin-induced nephrotoxicity in rats","volume":"23","author":"Arjinajarn","year":"2016","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bbadis.2018.03.017_bb0245","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0164528","article-title":"Amelioration of renal inflammation, endoplasmic reticulum stress and apoptosis underlies the protective effect of low dosage of atorvastatin in gentamicin-induced nephrotoxicity","volume":"11","author":"Jaikumkao","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2018.03.017_bb0250","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0108889","article-title":"Tempol, a superoxide dismutase mimetic agent, ameliorates cisplatin-induced nephrotoxicity through alleviation of mitochondrial dysfunction in mice","volume":"9","author":"Ahmed","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2018.03.017_bb0255","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1097\/MAJ.0b013e3182831740","article-title":"Decreased renal organic anion transporter 3 expression in type 1 diabetic rats","volume":"347","author":"Phatchawan","year":"2014","journal-title":"Am J Med Sci"},{"key":"10.1016\/j.bbadis.2018.03.017_bb0260","doi-asserted-by":"crossref","first-page":"291087","DOI":"10.1155\/2012\/291087","article-title":"Low-dose radiation activates Akt and Nrf2 in the kidney of diabetic mice: a potential mechanism to prevent diabetic nephropathy","volume":"2012","author":"Xing","year":"2012","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0265","doi-asserted-by":"crossref","first-page":"12475","DOI":"10.1073\/pnas.220418997","article-title":"Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2","volume":"97","author":"Huang","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0270","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1159\/000093632","article-title":"Insulin resistance, hyperinsulinemia, and renal injury: mechanisms and implications","volume":"26","author":"Sarafidis","year":"2006","journal-title":"Am. J. Nephrol."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0275","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s12933-014-0148-1","article-title":"Glycemic control with empagliflozin, a novel selective SGLT2 inhibitor, ameliorates cardiovascular injury and cognitive dysfunction in obese and type 2 diabetic mice","volume":"13","author":"Lin","year":"2014","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0280","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.2337\/db07-1472","article-title":"Dapagliflozin, a selective SGLT2 inhibitor, improves glucose homeostasis in normal and diabetic rats","volume":"57","author":"Han","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2018.03.017_bb0285","doi-asserted-by":"crossref","first-page":"405","DOI":"10.7326\/0003-4819-156-6-201203200-00003","article-title":"Long-term efficacy of dapagliflozin in patients with type 2 diabetes mellitus receiving high doses of insulin: a randomized trial","volume":"156","author":"Wilding","year":"2012","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0290","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1741-7015-11-43","article-title":"Dapagliflozin add-on to metformin in type 2 diabetes inadequately controlled with metformin: a randomized, double-blind, placebo-controlled 102-week trial","volume":"11","author":"Bailey","year":"2013","journal-title":"BMC Med."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0295","doi-asserted-by":"crossref","first-page":"F1078","DOI":"10.1152\/ajprenal.00333.2011","article-title":"Increased glomerular filtration rate in early metabolic syndrome is associated with renal adiposity and microvascular proliferation","volume":"301","author":"Li","year":"2011","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0300","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1161\/HYPERTENSIONAHA.107.095489","article-title":"Aldosterone and vascular inflammation","volume":"51","author":"Brown","year":"2008","journal-title":"Hypertension"},{"key":"10.1016\/j.bbadis.2018.03.017_bb0305","doi-asserted-by":"crossref","first-page":"F345","DOI":"10.1152\/ajprenal.00119.2005","article-title":"Mesangial cell NADPH oxidase upregulation in high glucose is protein kinase C dependent and required for collagen IV expression","volume":"290","author":"Xia","year":"2006","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0310","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1093\/mutage\/ges033","article-title":"Angiotensin II induces DNA damage via AT1 receptor and NADPH oxidase isoform Nox4","volume":"27","author":"Fazeli","year":"2012","journal-title":"Mutagenesis"},{"key":"10.1016\/j.bbadis.2018.03.017_bb0315","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1161\/01.CIR.98.22.2453","article-title":"Insulin induces upregulation of vascular AT1 receptor gene expression by posttranscriptional mechanisms","volume":"98","author":"Nickenig","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.bbadis.2018.03.017_bb0320","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1172\/JCI117621","article-title":"Nitric oxide release accounts for insulin's vascular effects in humans","volume":"94","author":"Scherrer","year":"1994","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0325","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1177\/2042018814544153","article-title":"Renal effects of dapagliflozin in patients with type 2 diabetes","volume":"5","author":"Thomas","year":"2014","journal-title":"Ther. Adv. Endocrinol. Metab."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0330","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1146\/annurev-physiol-020911-153333","article-title":"Renal function in diabetic disease models: the tubular system in the pathophysiology of the diabetic kidney","volume":"74","author":"Vallon","year":"2012","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0335","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4239\/wjd.v3.i1.1","article-title":"Renal hyperfiltration related to diabetes mellitus and obesity in human disease","volume":"3","author":"Sasson","year":"2012","journal-title":"World J. Diabetes"},{"key":"10.1016\/j.bbadis.2018.03.017_bb0340","doi-asserted-by":"crossref","first-page":"5335","DOI":"10.1074\/jbc.M117.779520","article-title":"SGLT2 protein expression is increased in human diabetic nephropathy: SGLT2 protein inhibition decreases renal lipid accumulation, inflammation, and the development of nephropathy in diabetic mice","volume":"292","author":"Wang","year":"2017","journal-title":"J. Biol. Chem."},{"issue":"Suppl. 2","key":"10.1016\/j.bbadis.2018.03.017_bb0345","doi-asserted-by":"crossref","first-page":"S165","DOI":"10.2337\/dcS15-3006","article-title":"SGLT2 inhibitors and the diabetic kidney","volume":"39","author":"Fioretto","year":"2016","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bbadis.2018.03.017_bb0350","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/nrendo.2015.10","article-title":"Adenosine signalling in diabetes mellitus\u2013pathophysiology and therapeutic considerations","volume":"11","author":"Antonioli","year":"2015","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0355","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1681\/ASN.2010030246","article-title":"SGLT2 mediates glucose reabsorption in the early proximal tubule","volume":"22","author":"Vallon","year":"2011","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0360","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1530\/JOE-17-0471","article-title":"Prebiotic prevents impaired kidney and renal Oat3 functions in obese rats","volume":"237","author":"Wanchai","year":"2018","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0365","doi-asserted-by":"crossref","first-page":"26428","DOI":"10.1038\/srep26428","article-title":"Once daily administration of the SGLT2 inhibitor, empagliflozin, attenuates markers of renal fibrosis without improving albuminuria in diabetic db\/db mice","volume":"6","author":"Gallo","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0370","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.cbi.2011.03.014","article-title":"Metformin attenuates streptozotocin-induced diabetic nephropathy in rats through modulation of oxidative stress genes expression","volume":"192","author":"Alhaider","year":"2011","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0375","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1159\/000481951","article-title":"Renoprotective effects of metformin","volume":"138","author":"De Broe","year":"2017","journal-title":"Nephron"},{"key":"10.1016\/j.bbadis.2018.03.017_bb0380","doi-asserted-by":"crossref","first-page":"75","DOI":"10.2147\/IJNRD.S39739","article-title":"Obesity, hypertension, and chronic kidney disease","volume":"7","author":"Hall","year":"2014","journal-title":"Int. J. Nephrol. Renov. Dis."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0385","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1681\/ASN.V1261211","article-title":"Functional and structural changes in the kidney in the early stages of obesity","volume":"12","author":"Henegar","year":"2001","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0390","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/ki.2011.404","article-title":"Glomerular hyperfiltration and increased glomerular filtration surface are associated with renal function decline in normo- and microalbuminuric type 2 diabetes","volume":"81","author":"Moriya","year":"2012","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0395","doi-asserted-by":"crossref","first-page":"320167","DOI":"10.1155\/2015\/320167","article-title":"Antidiabetic and renoprotective effects of Cladophora glomerata Kutzing extract in experimental type 2 diabetic rats: a potential nutraceutical product for diabetic nephropathy","volume":"2015","author":"Srimaroeng","year":"2015","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0400","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1208\/s12248-012-9413-y","article-title":"Renal organic anion transporters (SLC22 family): expression, regulation, roles in toxicity, and impact on injury and disease","volume":"15","author":"Wang","year":"2013","journal-title":"AAPS J."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0405","doi-asserted-by":"crossref","first-page":"4939","DOI":"10.1038\/s41598-017-04949-2","article-title":"Key role for the organic anion transporters, OAT1 and OAT3, in the in vivo handling of uremic toxins and solutes","volume":"7","author":"Wu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0410","doi-asserted-by":"crossref","first-page":"F1293","DOI":"10.1152\/ajprenal.00013.2012","article-title":"A role for the organic anion transporter OAT3 in renal creatinine secretion in mice","volume":"302","author":"Vallon","year":"2012","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.bbadis.2018.03.017_bb0415","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1074\/jbc.M808078200","article-title":"Activation of protein kinase Czeta increases OAT1 (SLC22A6)- and OAT3 (SLC22A8)-mediated transport","volume":"284","author":"Barros","year":"2009","journal-title":"J. Biol. Chem."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443918300978?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443918300978?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T15:38:32Z","timestamp":1660664312000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443918300978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":83,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["S0925443918300978"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2018.03.017","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Renal outcomes with sodium glucose cotransporter 2 (SGLT2) inhibitor, dapagliflozin, in obese insulin-resistant model","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2018.03.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V.","name":"copyright","label":"Copyright"}]}}