{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:24:10Z","timestamp":1762867450138,"version":"build-2065373602"},"reference-count":100,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,6,14]],"date-time":"2018-06-14T00:00:00Z","timestamp":1528934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Spanish Ministry of Economy and Competitiveness","award":["BFU2014-58673-P"],"award-info":[{"award-number":["BFU2014-58673-P"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.bbadis.2018.06.014","type":"journal-article","created":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T08:17:27Z","timestamp":1529396247000},"page":"3022-3037","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"PB","title":["The MELAS mutation m.3243A&gt;G promotes reactivation of fetal cardiac genes and an epithelial-mesenchymal transition-like program via dysregulation of miRNAs"],"prefix":"10.1016","volume":"1864","author":[{"given":"Salvador","family":"Meseguer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaquin","family":"Panadero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Navarro-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magda","family":"Villarroya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachid","family":"Boutoual","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giacomo Pietro","family":"Comi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.-Eugenia","family":"Armengod","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.bbadis.2018.06.014_bb0005","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.cell.2012.02.035","article-title":"Mitochondria: in sickness and in health","volume":"148","author":"Nunnari","year":"2012","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.bbadis.2018.06.014_bb0010","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.bbadis.2009.04.003","article-title":"OXPHOS gene expression and control in mitochondrial disorders","volume":"1792","author":"Reinecke","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2018.06.014_bb0015","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1741-7007-12-34","article-title":"Mitochondria as signaling organelles","volume":"12","author":"Chandel","year":"2014","journal-title":"BMC Biol."},{"issue":"Pt 4","key":"10.1016\/j.bbadis.2018.06.014_bb0020","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1242\/jcs.099234","article-title":"Mitochondria and cell signalling","volume":"125","author":"Tait","year":"2012","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbadis.2018.06.014_bb0025","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.biocel.2013.12.011","article-title":"Mitochondria: impaired mitochondrial translation in human disease","volume":"48","author":"Boczonadi","year":"2014","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"8","key":"10.1016\/j.bbadis.2018.06.014_bb0030","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nrneurol.2013.126","article-title":"The clinical maze of mitochondrial neurology","volume":"9","author":"DiMauro","year":"2013","journal-title":"Nat. Rev. Neurol."},{"issue":"9","key":"10.1016\/j.bbadis.2018.06.014_bb0035","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.bbabio.2011.06.010","article-title":"Human diseases with impaired mitochondrial protein synthesis","volume":"1807","author":"Rotig","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2018.06.014_bb0040","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.biocel.2015.01.026","article-title":"The complex crosstalk between mitochondria and the nucleus: what goes in between?","volume":"63","author":"Cagin","year":"2015","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"12","key":"10.1016\/j.bbadis.2018.06.014_bb0045","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1007\/s13238-015-0175-z","article-title":"A peep into mitochondrial disorder: multifaceted from mitochondrial DNA mutations to nuclear gene modulation","volume":"6","author":"Chen","year":"2015","journal-title":"Protein Cell."},{"issue":"3","key":"10.1016\/j.bbadis.2018.06.014_bb0050","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.cmet.2014.02.004","article-title":"Tissue-specific loss of DARS2 activates stress responses independently of respiratory chain deficiency in the heart","volume":"19","author":"Dogan","year":"2014","journal-title":"Cell Metab."},{"issue":"38","key":"10.1016\/j.bbadis.2018.06.014_bb0055","doi-asserted-by":"crossref","first-page":"E4033","DOI":"10.1073\/pnas.1414028111","article-title":"Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming","volume":"111","author":"Picard","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.bbadis.2018.06.014_bb0060","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1093\/ije\/dyr232","article-title":"Epigenetics, epidemiology and mitochondrial DNA diseases","volume":"41","author":"Chinnery","year":"2012","journal-title":"Int. J. Epidemiol."},{"issue":"1","key":"10.1016\/j.bbadis.2018.06.014_bb0065","doi-asserted-by":"crossref","first-page":"6209","DOI":"10.1038\/s41598-017-06553-w","article-title":"microRNA-mediated differential expression of TRMU, GTPBP3 and MTO1 in cell models of mitochondrial-DNA diseases","volume":"7","author":"Meseguer","year":"2017","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.bbadis.2018.06.014_bb0070","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1093\/hmg\/ddu427","article-title":"The ROS-sensitive microRNA-9\/9* controls the expression of mitochondrial tRNA-modifying enzymes and is involved in the molecular mechanism of MELAS syndrome","volume":"24","author":"Meseguer","year":"2015","journal-title":"Hum. Mol. Genet."},{"issue":"9","key":"10.1016\/j.bbadis.2018.06.014_bb0075","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.15252\/embj.201695546","article-title":"Non-coding RNAs: the dark side of nuclear-mitochondrial communication","volume":"36","author":"Vendramin","year":"2017","journal-title":"EMBO J."},{"key":"10.1016\/j.bbadis.2018.06.014_bb0080","article-title":"Identification of miRNA, lncRNA and mRNA-associated ceRNA networks and potential biomarker for MELAS with mitochondrial DNA A3243G mutation","volume":"7","author":"Wang","year":"2017","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.bbadis.2018.06.014_bb0085","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/nrg1379","article-title":"MicroRNAs: small RNAs with a big role in gene regulation","volume":"5","author":"He","year":"2004","journal-title":"Nat. Rev. Genet."},{"issue":"11","key":"10.1016\/j.bbadis.2018.06.014_bb0090","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.bbamcr.2010.06.013","article-title":"MicroRNAs: synthesis, mechanism, function, and recent clinical trials","volume":"1803","author":"Wahid","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"issue":"3","key":"10.1016\/j.bbadis.2018.06.014_bb0095","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1002\/jcp.25854","article-title":"Interplay between miRNAs and human diseases","volume":"233","author":"Paul","year":"2018","journal-title":"J. Cell. Physiol."},{"year":"1993","series-title":"Melas","author":"DiMauro","key":"10.1016\/j.bbadis.2018.06.014_bb0100"},{"issue":"1\u20132","key":"10.1016\/j.bbadis.2018.06.014_bb0105","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.ymgme.2015.06.004","article-title":"MELAS syndrome: clinical manifestations, pathogenesis, and treatment options","volume":"116","author":"El-Hattab","year":"2015","journal-title":"Mol. Genet. Metab."},{"issue":"24","key":"10.1016\/j.bbadis.2018.06.014_bb0110","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.1093\/eurheartj\/ehs275","article-title":"Cardiac involvement in mitochondrial DNA disease: clinical spectrum, diagnosis, and management","volume":"33","author":"Bates","year":"2012","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.bbadis.2018.06.014_bb0115","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1471-2261-2-12","article-title":"Cardiac abnormalities in patients with mitochondrial DNA mutation 3243A>G","volume":"2","author":"Majamaa-Voltti","year":"2002","journal-title":"BMC Cardiovasc. Disord."},{"issue":"2","key":"10.1016\/j.bbadis.2018.06.014_bb0120","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.ajhg.2008.07.004","article-title":"Pathogenic mitochondrial DNA mutations are common in the general population","volume":"83","author":"Elliott","year":"2008","journal-title":"Am. J. Hum. Genet."},{"issue":"5","key":"10.1016\/j.bbadis.2018.06.014_bb0125","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1002\/ana.24362","article-title":"Prevalence of nuclear and mitochondrial DNA mutations related to adult mitochondrial disease","volume":"77","author":"Gorman","year":"2015","journal-title":"Ann. Neurol."},{"issue":"32","key":"10.1016\/j.bbadis.2018.06.014_bb0130","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1093\/eurheartj\/ehv306","article-title":"Sudden adult death syndrome in m.3243A>G-related mitochondrial disease: an unrecognized clinical entity in young, asymptomatic adults","volume":"37","author":"Ng","year":"2016","journal-title":"Eur. Heart J."},{"issue":"1","key":"10.1016\/j.bbadis.2018.06.014_bb0135","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/ajmg.1392","article-title":"Mitochondrial DNA mutations in human disease","volume":"106","author":"DiMauro","year":"2001","journal-title":"Am. J. Med. Genet."},{"issue":"6","key":"10.1016\/j.bbadis.2018.06.014_bb0140","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.mito.2007.07.001","article-title":"Nuclear-mitochondrial interaction","volume":"7","author":"Cannino","year":"2007","journal-title":"Mitochondrion"},{"issue":"4","key":"10.1016\/j.bbadis.2018.06.014_bb0145","doi-asserted-by":"crossref","first-page":"326","DOI":"10.4161\/epi.19547","article-title":"Mitochondrial regulation of epigenetics and its role in human diseases","volume":"7","author":"Minocherhomji","year":"2012","journal-title":"Epigenetics"},{"issue":"9","key":"10.1016\/j.bbadis.2018.06.014_bb0150","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/nrg3966","article-title":"The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease","volume":"16","author":"Stewart","year":"2015","journal-title":"Nat Rev Genet."},{"issue":"2","key":"10.1016\/j.bbadis.2018.06.014_bb0155","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.cmet.2017.07.003","article-title":"Increased Total mtDNA copy number cures male infertility despite unaltered mtDNA mutation load","volume":"26","author":"Jiang","year":"2017","journal-title":"Cell Metab."},{"issue":"12","key":"10.1016\/j.bbadis.2018.06.014_bb0160","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1016\/j.bbadis.2013.07.023","article-title":"Regulation of fetal gene expression in heart failure","volume":"1832","author":"Dirkx","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"issue":"42","key":"10.1016\/j.bbadis.2018.06.014_bb0165","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.1093\/eurheartj\/ehv307","article-title":"Long-term cardiac prognosis and risk stratification in 260 adults presenting with mitochondrial diseases","volume":"36","author":"Wahbi","year":"2015","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.bbadis.2018.06.014_bb0170","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/S0076-6879(96)64031-2","article-title":"Platelet-mediated transformation of human mitochondrial DNA-less cells","volume":"264","author":"Chomyn","year":"1996","journal-title":"Methods Enzymol."},{"issue":"1","key":"10.1016\/j.bbadis.2018.06.014_bb0175","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3346\/jkms.2002.17.1.103","article-title":"Histochemical and molecular genetic study of MELAS and MERRF in Korean patients","volume":"17","author":"Kim","year":"2002","journal-title":"J. Korean Med. Sci."},{"issue":"2","key":"10.1016\/j.bbadis.2018.06.014_bb0180","doi-asserted-by":"crossref","first-page":"225","DOI":"10.2353\/jmoldx.2006.050067","article-title":"Rapid and sensitive real-time polymerase chain reaction method for detection and quantification of 3243A>G mitochondrial point mutation","volume":"8","author":"Singh","year":"2006","journal-title":"J. Mol. Diagn."},{"issue":"18","key":"10.1016\/j.bbadis.2018.06.014_bb0185","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1093\/bioinformatics\/btw334","article-title":"Integrated gene set analysis for microRNA studies","volume":"32","author":"Garcia-Garcia","year":"2016","journal-title":"Bioinformatics"},{"issue":"12","key":"10.1016\/j.bbadis.2018.06.014_bb0190","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1038\/nbt1372","article-title":"Endogenous microRNA can be broadly exploited to regulate transgene expression according to tissue, lineage and differentiation state","volume":"25","author":"Brown","year":"2007","journal-title":"Nat. Biotechnol."},{"issue":"2","key":"10.1016\/j.bbadis.2018.06.014_bb0195","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1159\/000445638","article-title":"Smad2\/3\/4 pathway contributes to TGF-beta-induced MiRNA-181b expression to promote gastric cancer metastasis by targeting Timp3","volume":"39","author":"Zhou","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"issue":"3","key":"10.1016\/j.bbadis.2018.06.014_bb0200","doi-asserted-by":"crossref","first-page":"195","DOI":"10.14348\/molcells.2017.2291","article-title":"MiR-186 inhibited migration of NSCLC via targeting cdc42 and effecting EMT process","volume":"40","author":"Dong","year":"2017","journal-title":"Mol Cells."},{"issue":"4","key":"10.1016\/j.bbadis.2018.06.014_bb0205","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.bbrc.2016.06.133","article-title":"MiR-27b is epigenetically downregulated in tamoxifen resistant breast cancer cells due to promoter methylation and regulates tamoxifen sensitivity by targeting HMGB3","volume":"477","author":"Li","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"8","key":"10.1016\/j.bbadis.2018.06.014_bb0210","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1002\/ejhf.517","article-title":"The transcardiac gradient of cardio-microRNAs in the failing heart","volume":"18","author":"Marques","year":"2016","journal-title":"Eur. J. Heart Fail."},{"issue":"3","key":"10.1016\/j.bbadis.2018.06.014_bb0215","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1161\/CIRCULATIONAHA.107.687947","article-title":"MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure","volume":"116","author":"Thum","year":"2007","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.bbadis.2018.06.014_bb0220","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/j.1751-7133.2009.00108.x","article-title":"Heart diseases in mitochondrial encephalomyopathy, lactic acidosis, and stroke syndrome","volume":"15","author":"Fayssoil","year":"2009","journal-title":"Congest. Heart Fail."},{"issue":"3","key":"10.1016\/j.bbadis.2018.06.014_bb0225","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1136\/hrt.80.3.292","article-title":"A follow up study of myocardial involvement in patients with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS)","volume":"80","author":"Okajima","year":"1998","journal-title":"Heart"},{"issue":"4","key":"10.1016\/j.bbadis.2018.06.014_bb0230","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1542\/peds.2004-0718","article-title":"Clinical spectrum, morbidity, and mortality in 113 pediatric patients with mitochondrial disease","volume":"114","author":"Scaglia","year":"2004","journal-title":"Pediatrics"},{"issue":"2","key":"10.1016\/j.bbadis.2018.06.014_bb0235","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1136\/jnnp.2007.122648","article-title":"Causes of death in pedigrees with the 3243A>G mutation in mitochondrial DNA","volume":"79","author":"Majamaa-Voltti","year":"2008","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"4","key":"10.1016\/j.bbadis.2018.06.014_bb0240","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1084\/jem.20122126","article-title":"RhoGEF12 controls cardiac remodeling by integrating G protein- and integrin-dependent signaling cascades","volume":"210","author":"Takefuji","year":"2013","journal-title":"J. Exp. Med."},{"issue":"3","key":"10.1016\/j.bbadis.2018.06.014_bb0245","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1091\/mbc.01-08-0398","article-title":"Transforming growth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA","volume":"13","author":"Edlund","year":"2002","journal-title":"Mol. Biol. Cell"},{"issue":"1","key":"10.1016\/j.bbadis.2018.06.014_bb0250","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1091\/mbc.12.1.27","article-title":"Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism","volume":"12","author":"Bhowmick","year":"2001","journal-title":"Mol. Biol. Cell"},{"issue":"3","key":"10.1016\/j.bbadis.2018.06.014_bb0255","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nrm3758","article-title":"Molecular mechanisms of epithelial-mesenchymal transition","volume":"15","author":"Lamouille","year":"2014","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"issue":"12","key":"10.1016\/j.bbadis.2018.06.014_bb0260","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1161\/CIRCRESAHA.111.259960","article-title":"Endocardial and epicardial epithelial to mesenchymal transitions in heart development and disease","volume":"110","author":"von Gise","year":"2012","journal-title":"Circ. Res."},{"issue":"14","key":"10.1016\/j.bbadis.2018.06.014_bb0265","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1161\/CIRCULATIONAHA.111.040352","article-title":"Epithelial-to-mesenchymal and endothelial-to-mesenchymal transition: from cardiovascular development to disease","volume":"125","author":"Kovacic","year":"2012","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.bbadis.2018.06.014_bb0270","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.yjmcc.2010.10.033","article-title":"Transforming growth factor (TGF)-beta signaling in cardiac remodeling","volume":"51","author":"Dobaczewski","year":"2011","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"6","key":"10.1016\/j.bbadis.2018.06.014_bb0275","first-page":"1289","article-title":"Role of TGF-beta on cardiac structural and electrical remodeling","volume":"4","author":"Ramos-Mondragon","year":"2008","journal-title":"Vasc. Health Risk Manag."},{"issue":"2","key":"10.1016\/j.bbadis.2018.06.014_bb0280","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/cr.2009.5","article-title":"TGF-beta-induced epithelial to mesenchymal transition","volume":"19","author":"Xu","year":"2009","journal-title":"Cell Res."},{"issue":"10","key":"10.1016\/j.bbadis.2018.06.014_bb0285","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1161\/01.RES.86.10.1019","article-title":"Small guanine nucleotide-binding proteins and myocardial hypertrophy","volume":"86","author":"Clerk","year":"2000","journal-title":"Circ. Res."},{"issue":"10","key":"10.1016\/j.bbadis.2018.06.014_bb0290","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a011197","article-title":"Signaling by the TGFbeta superfamily","volume":"5","author":"Wrana","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"3","key":"10.1016\/j.bbadis.2018.06.014_bb0295","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.biocel.2011.12.013","article-title":"A portrait of transforming growth factor beta superfamily signalling: background matters","volume":"44","author":"Horbelt","year":"2012","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"6","key":"10.1016\/j.bbadis.2018.06.014_bb0300","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/S1534-5807(03)00363-0","article-title":"Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart","volume":"5","author":"Cai","year":"2003","journal-title":"Dev. Cell"},{"issue":"23","key":"10.1016\/j.bbadis.2018.06.014_bb0305","doi-asserted-by":"crossref","first-page":"4749","DOI":"10.1242\/dev.124.23.4749","article-title":"Vitamin A deficiency and mutations of RXRalpha, RXRbeta and RARalpha lead to early differentiation of embryonic ventricular cardiomyocytes","volume":"124","author":"Kastner","year":"1997","journal-title":"Development"},{"issue":"7","key":"10.1016\/j.bbadis.2018.06.014_bb0310","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nrg2340","article-title":"Retinoic acid in development: towards an integrated view","volume":"9","author":"Niederreither","year":"2008","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.bbadis.2018.06.014_bb0315","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.mod.2016.12.002","article-title":"Mechanisms of retinoic acid signaling during cardiogenesis","volume":"143","author":"Stefanovic","year":"2017","journal-title":"Mech. Dev."},{"issue":"14","key":"10.1016\/j.bbadis.2018.06.014_bb0320","doi-asserted-by":"crossref","first-page":"6741","DOI":"10.1093\/nar\/gkw301","article-title":"ISL1 and JMJD3 synergistically control cardiac differentiation of embryonic stem cells","volume":"44","author":"Wang","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbadis.2018.06.014_bb0325","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/978-1-62703-083-0_10","article-title":"Evaluating the microRNA targeting sites by luciferase reporter gene assay","volume":"936","author":"Jin","year":"2013","journal-title":"Methods Mol. Biol."},{"issue":"5","key":"10.1016\/j.bbadis.2018.06.014_bb0330","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a003459","article-title":"Nodal morphogens","volume":"1","author":"Schier","year":"2009","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"1","key":"10.1016\/j.bbadis.2018.06.014_bb0335","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3109\/10409238.2013.857291","article-title":"Signaling pathways controlling skeletal muscle mass","volume":"49","author":"Egerman","year":"2014","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"issue":"36","key":"10.1016\/j.bbadis.2018.06.014_bb0340","doi-asserted-by":"crossref","first-page":"33986","DOI":"10.1074\/jbc.M100093200","article-title":"Cross-talk between the p42\/p44 MAP kinase and Smad pathways in transforming growth factor beta 1-induced furin gene transactivation","volume":"276","author":"Blanchette","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.bbadis.2018.06.014_bb0345","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1096\/fj.09-151639","article-title":"Vimentin induces changes in cell shape, motility, and adhesion during the epithelial to mesenchymal transition","volume":"24","author":"Mendez","year":"2010","journal-title":"FASEB J."},{"issue":"1","key":"10.1016\/j.bbadis.2018.06.014_bb0350","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1124\/mol.62.1.65","article-title":"SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7","volume":"62","author":"Inman","year":"2002","journal-title":"Mol. Pharmacol."},{"issue":"4","key":"10.1016\/j.bbadis.2018.06.014_bb0355","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1007\/s12265-010-9192-8","article-title":"Revisited and revised: is RhoA always a villain in cardiac pathophysiology?","volume":"3","author":"Miyamoto","year":"2010","journal-title":"J. Cardiovasc. Transl. Res."},{"issue":"131","key":"10.1016\/j.bbadis.2018.06.014_bb0360","doi-asserted-by":"crossref","DOI":"10.1098\/rsif.2017.0071","article-title":"Mitochondrial DNA 3243A>G heteroplasmy is associated with changes in cytoskeletal protein expression and cell mechanics","volume":"14","author":"Kandel","year":"2017","journal-title":"J. R. Soc. Interface"},{"issue":"16","key":"10.1016\/j.bbadis.2018.06.014_bb0365","doi-asserted-by":"crossref","first-page":"3931","DOI":"10.1242\/dev.01256","article-title":"Mef2c is a direct transcriptional target of ISL1 and GATA factors in the anterior heart field during mouse embryonic development","volume":"131","author":"Dodou","year":"2004","journal-title":"Development"},{"issue":"4","key":"10.1016\/j.bbadis.2018.06.014_bb0370","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1002\/stem.1923","article-title":"Direct nkx2-5 transcriptional repression of isl1 controls cardiomyocyte subtype identity","volume":"33","author":"Dorn","year":"2015","journal-title":"Stem Cells"},{"issue":"Pt 10","key":"10.1016\/j.bbadis.2018.06.014_bb0375","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1093\/brain\/120.10.1713","article-title":"Molecular pathology of MELAS and MERRF. The relationship between mutation load and clinical phenotypes","volume":"120","author":"Chinnery","year":"1997","journal-title":"Brain"},{"issue":"23","key":"10.1016\/j.bbadis.2018.06.014_bb0380","doi-asserted-by":"crossref","first-page":"4418","DOI":"10.1242\/dev.091538","article-title":"How to make a cardiomyocyte","volume":"141","author":"Spater","year":"2014","journal-title":"Development"},{"issue":"3","key":"10.1016\/j.bbadis.2018.06.014_bb0385","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1093\/cvr\/cvs270","article-title":"Early cardiac development: a view from stem cells to embryos","volume":"96","author":"Van Vliet","year":"2012","journal-title":"Cardiovasc. Res."},{"issue":"4","key":"10.1016\/j.bbadis.2018.06.014_bb0390","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1101\/gad.2018411","article-title":"Cardiac muscle regeneration: lessons from development","volume":"25","author":"Mercola","year":"2011","journal-title":"Genes Dev."},{"issue":"2","key":"10.1016\/j.bbadis.2018.06.014_bb0395","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nrm2618","article-title":"Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo","volume":"10","author":"Arnold","year":"2009","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"issue":"3","key":"10.1016\/j.bbadis.2018.06.014_bb0400","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1161\/01.RES.0000154912.08695.88","article-title":"Vangl2 acts via RhoA signaling to regulate polarized cell movements during development of the proximal outflow tract","volume":"96","author":"Phillips","year":"2005","journal-title":"Circ. Res."},{"issue":"7","key":"10.1016\/j.bbadis.2018.06.014_bb0405","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1242\/dev.129.7.1705","article-title":"Inhibition of Rho family GTPases by Rho GDP dissociation inhibitor disrupts cardiac morphogenesis and inhibits cardiomyocyte proliferation","volume":"129","author":"Wei","year":"2002","journal-title":"Development"},{"issue":"3","key":"10.1016\/j.bbadis.2018.06.014_bb0410","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/dvdy.24085","article-title":"Embryonic expression of the transforming growth factor beta ligand and receptor genes in chicken","volume":"243","author":"Cooley","year":"2014","journal-title":"Dev. Dyn."},{"issue":"4","key":"10.1016\/j.bbadis.2018.06.014_bb0415","first-page":"385","article-title":"Mitochondrial cardiomyopathy: pathophysiology, diagnosis, and management","volume":"40","author":"Meyers","year":"2013","journal-title":"Tex. Heart Inst. J."},{"issue":"10","key":"10.1016\/j.bbadis.2018.06.014_bb0420","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1161\/01.RES.0000072977.86706.23","article-title":"Roles of cardiac transcription factors in cardiac hypertrophy","volume":"92","author":"Akazawa","year":"2003","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.bbadis.2018.06.014_bb0425","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.semcdb.2006.11.012","article-title":"Re-employment of developmental transcription factors in adult heart disease","volume":"18","author":"Oka","year":"2007","journal-title":"Semin. Cell Dev. Biol."},{"issue":"6","key":"10.1016\/j.bbadis.2018.06.014_bb0430","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1172\/JCI39104","article-title":"The basics of epithelial-mesenchymal transition","volume":"119","author":"Kalluri","year":"2009","journal-title":"J. Clin. Invest."},{"issue":"5","key":"10.1016\/j.bbadis.2018.06.014_bb0435","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.cell.2009.11.007","article-title":"Epithelial-mesenchymal transitions in development and disease","volume":"139","author":"Thiery","year":"2009","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.bbadis.2018.06.014_bb0440","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.ceb.2003.10.006","article-title":"Epithelial-mesenchymal transitions in development and pathologies","volume":"15","author":"Thiery","year":"2003","journal-title":"Curr. Opin. Cell Biol."},{"issue":"2","key":"10.1016\/j.bbadis.2018.06.014_bb0445","doi-asserted-by":"crossref","DOI":"10.3390\/jcm5020027","article-title":"Epicardial epithelial-to-mesenchymal transition in heart development and disease","volume":"5","author":"Krainock","year":"2016","journal-title":"J. Clin. Med."},{"issue":"2","key":"10.1016\/j.bbadis.2018.06.014_bb0450","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1093\/eurjhf\/hfp186","article-title":"Prevalence and natural history of heart disease in adults with primary mitochondrial respiratory chain disease","volume":"12","author":"Limongelli","year":"2010","journal-title":"Eur. J. Heart Fail."},{"issue":"6","key":"10.1016\/j.bbadis.2018.06.014_bb0455","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0092-8674(03)00432-X","article-title":"Mechanisms of TGF-beta signaling from cell membrane to the nucleus","volume":"113","author":"Shi","year":"2003","journal-title":"Cell"},{"year":"2007","series-title":"The TGF-Beta Family","author":"Derynck","key":"10.1016\/j.bbadis.2018.06.014_bb0460"},{"issue":"9","key":"10.1016\/j.bbadis.2018.06.014_bb0465","doi-asserted-by":"crossref","first-page":"7409","DOI":"10.1074\/jbc.R400029200","article-title":"Latent transforming growth factor-beta (TGF-beta) binding proteins: orchestrators of TGF-beta availability","volume":"280","author":"Rifkin","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.bbadis.2018.06.014_bb0470","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/jcb.21501","article-title":"TGF-beta signaling: a tale of two responses","volume":"102","author":"Rahimi","year":"2007","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bbadis.2018.06.014_bb0475","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1146\/annurev.cellbio.21.022404.142018","article-title":"Specificity and versatility in tgf-beta signaling through Smads","volume":"21","author":"Feng","year":"2005","journal-title":"Annu. Rev. Cell Dev. Biol."},{"issue":"3","key":"10.1016\/j.bbadis.2018.06.014_bb0480","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.biocel.2007.09.006","article-title":"How the Smads regulate transcription","volume":"40","author":"Ross","year":"2008","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"1","key":"10.1016\/j.bbadis.2018.06.014_bb0485","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/cr.2008.328","article-title":"Non-Smad pathways in TGF-beta signaling","volume":"19","author":"Zhang","year":"2009","journal-title":"Cell Res."},{"issue":"Pt 20","key":"10.1016\/j.bbadis.2018.06.014_bb0490","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.1242\/jcs.018473","article-title":"Actin stress fibres","volume":"120","author":"Pellegrin","year":"2007","journal-title":"J. Cell Sci."},{"issue":"6","key":"10.1016\/j.bbadis.2018.06.014_bb0495","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1002\/dvdy.20771","article-title":"TGF beta-mediated RhoA expression is necessary for epithelial-mesenchymal transition in the embryonic chick heart","volume":"235","author":"Tavares","year":"2006","journal-title":"Dev. Dyn."},{"issue":"11","key":"10.1016\/j.bbadis.2018.06.014_bb0500","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1111\/j.1742-4658.2009.07031.x","article-title":"Control of transforming growth factor beta signal transduction by small GTPases","volume":"276","author":"Kardassis","year":"2009","journal-title":"FEBS J."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443918302187?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443918302187?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T04:43:24Z","timestamp":1760417004000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443918302187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":100,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["S0925443918302187"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2018.06.014","relation":{},"ISSN":["0925-4439"],"issn-type":[{"type":"print","value":"0925-4439"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The MELAS mutation m.3243A>G promotes reactivation of fetal cardiac genes and an epithelial-mesenchymal transition-like program via dysregulation of miRNAs","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2018.06.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}