{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:34:18Z","timestamp":1790609658211,"version":"4.1.0"},"reference-count":73,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100022108","name":"Universit\u00e9 de Poitiers","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004793","name":"Minist\u00e8re de l'Education Nationale, de l'Enseignement Sup\u00e9rieur et de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["P-2016-BAFE28"],"award-info":[{"award-number":["P-2016-BAFE28"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019920","name":"Soci\u00e9t\u00e9 d'Acc\u00e9l\u00e9ration du Transfert de Technologies","doi-asserted-by":"publisher","award":["0314-CNRS-LIPOMUCO"],"award-info":[{"award-number":["0314-CNRS-LIPOMUCO"]}],"id":[{"id":"10.13039\/501100019920","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.bbadis.2018.06.021","type":"journal-article","created":{"date-parts":[[2018,6,27]],"date-time":"2018-06-27T22:41:00Z","timestamp":1530139260000},"page":"3069-3084","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"PB","title":["Modulation of cellular membrane properties as a potential therapeutic strategy to counter lipointoxication in obstructive pulmonary diseases"],"prefix":"10.1016","volume":"1864","author":[{"given":"Linette","family":"Kadri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Ferru-Cl\u00e9ment","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lie","family":"Bacle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie-Anne","family":"Payet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Cantereau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reynald","family":"H\u00e9lye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Becq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Jayle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarisse","family":"Vandebrouck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2018.06.021_bb0005","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1183\/09031936.00141514","article-title":"The innate immune function of airway epithelial cells in inflammatory lung disease","volume":"45","author":"Hiemstra","year":"2015","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.bbadis.2018.06.021_bb0010","first-page":"L530","article-title":"Cigarette smoke and CFTR: implications in the pathogenesis of COPD","volume":"305","author":"Rab","year":"2013","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"key":"10.1016\/j.bbadis.2018.06.021_bb0015","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.6061\/clinics\/2012(11)19","article-title":"Airway disease: similarities and differences between asthma, COPD and bronchiectasis","volume":"67","author":"Athanazio","year":"2012","journal-title":"Clinics"},{"key":"10.1016\/j.bbadis.2018.06.021_bb0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0089044","article-title":"Cystic fibrosis bronchial epithelial cells are lipointoxicated by membrane palmitate accumulation","volume":"9","author":"Payet","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2018.06.021_bb0025","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.tcb.2015.03.004","article-title":"From zero to six double bonds: phospholipid unsaturation and organelle function","volume":"25","author":"Antonny","year":"2015","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.bbadis.2018.06.021_bb0030","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1111\/j.1567-1364.2010.00674.x","article-title":"Lipid-induced ER stress in yeast and \u03b2 cells: parallel trails to a common fate","volume":"10","author":"Pineau","year":"2010","journal-title":"FEMS Yeast Res."},{"key":"10.1016\/j.bbadis.2018.06.021_bb0035","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1600-0854.2010.01150.x","article-title":"Modulation of lipid-induced ER stress by fatty acid shape","volume":"12","author":"Deguil","year":"2011","journal-title":"Traffic"},{"key":"10.1016\/j.bbadis.2018.06.021_bb0040","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1016\/j.febslet.2011.05.045","article-title":"Structure-activity relationships influencing lipid-induced changes in eIF2alpha phosphorylation and cell viability in BRIN-BD11 cells","volume":"585","author":"Dhayal","year":"2011","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbadis.2018.06.021_bb0045","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1042\/BST0360959","article-title":"Differential regulation of the ER stress response by long-chain fatty acids in the pancreatic beta-cell","volume":"36","author":"Diakogiannaki","year":"2008","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.bbadis.2018.06.021_bb0050","doi-asserted-by":"crossref","first-page":"3398","DOI":"10.1210\/en.2005-1494","article-title":"Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis","volume":"147","author":"Karaskov","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbadis.2018.06.021_bb0055","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/j.1600-0854.2009.00903.x","article-title":"Lipid-induced ER stress: synergistic effects of sterols and saturated fatty acids","volume":"10","author":"Pineau","year":"2009","journal-title":"Traffic"},{"key":"10.1016\/j.bbadis.2018.06.021_bb0060","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1111\/tra.12117","article-title":"Saturated fatty acids alter the late secretory pathway by modulating membrane properties","volume":"14","author":"Payet","year":"2013","journal-title":"Traffic"},{"key":"10.1016\/j.bbadis.2018.06.021_bb0065","first-page":"199","article-title":"Hypoxemia in patients with COPD: cause, effects, and disease progression","volume":"6","author":"Kent","year":"2011","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"key":"10.1016\/j.bbadis.2018.06.021_bb0070","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1242\/jcs.183590","article-title":"Targeting surface voids to counter membrane disorders in lipointoxication-related diseases","volume":"129","author":"Ferru-Clement","year":"2016","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbadis.2018.06.021_bb0075","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nrm2330","article-title":"Membrane lipids: where they are and how they behave","volume":"9","author":"van Meer","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbadis.2018.06.021_bb0080","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s10337-014-2787-5","article-title":"Lipid analysis of airway epithelial cells for studying respiratory diseases","volume":"78","author":"Zehethofer","year":"2015","journal-title":"Chromatographia"},{"key":"10.1016\/j.bbadis.2018.06.021_bb0085","doi-asserted-by":"crossref","first-page":"7812","DOI":"10.1021\/jp071097f","article-title":"The MARTINI force field: coarse grained model for biomolecular simulations","volume":"111","author":"Marrink","year":"2007","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.bbadis.2018.06.021_bb0090","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/nature13474","article-title":"Lipid landscapes and pipelines in membrane homeostasis","volume":"510","author":"Holthuis","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2018.06.021_bb0095","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0007735","article-title":"A novel lipidomic strategy reveals plasma phospholipid signatures associated with respiratory disease severity in cystic fibrosis patients","volume":"4","author":"Guerrera","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2018.06.021_bb0100","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1126\/science.1255288","article-title":"Polyunsaturated phospholipids facilitate membrane deformation and fission by endocytic proteins","volume":"345","author":"Pinot","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2018.06.021_bb0105","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/S0006-3495(90)82637-0","article-title":"Phase fluctuation in phospholipid membranes revealed by Laurdan fluorescence","volume":"57","author":"Parasassi","year":"1990","journal-title":"Biophys. J."},{"key":"10.1016\/j.bbadis.2018.06.021_bb0110","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0006-3495(91)82041-0","article-title":"Quantitation of lipid phases in phospholipid vesicles by the generalized polarization of Laurdan fluorescence","volume":"60","author":"Parasassi","year":"1991","journal-title":"Biophys. J."},{"key":"10.1016\/j.bbadis.2018.06.021_bb0115","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1194\/jlr.D021311","article-title":"Imaging lipid lateral organization in membranes with C-laurdan in a confocal microscope","volume":"53","author":"Dodes Traian","year":"2012","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbadis.2018.06.021_bb0120","series-title":"T Cell Imaging Techniques","first-page":"483","article-title":"Histochemical detection of lipid droplets in cultured cells","author":"Suzuki","year":"2012"},{"key":"10.1016\/j.bbadis.2018.06.021_bb0125","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1042\/BC20100144","article-title":"Is fat so bad? Modulation of endoplasmic reticulum stress by lipid droplet formation","volume":"103","author":"Hapala","year":"2011","journal-title":"Biol. Cell."},{"key":"10.1016\/j.bbadis.2018.06.021_bb0130","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/1465-9921-7-53","article-title":"Role of apoptosis in the pathogenesis of COPD and pulmonary emphysema","volume":"7","author":"Demedts","year":"2006","journal-title":"Respir. Res."},{"key":"10.1016\/j.bbadis.2018.06.021_bb0135","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1513\/pats.200605-104SF","article-title":"Cell death, remodeling, and repair in chronic obstructive pulmonary disease?","volume":"3","author":"Henson","year":"2006","journal-title":"Proc. Am. Thorac. Soc."},{"key":"10.1016\/j.bbadis.2018.06.021_bb0140","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1007\/s10495-013-0874-y","article-title":"Apoptotic process in cystic fibrosis cells","volume":"18","author":"Soleti","year":"2013","journal-title":"Apoptosis"},{"key":"10.1016\/j.bbadis.2018.06.021_bb0145","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1183\/09031936.00063112","article-title":"Airway epithelial cell apoptosis and inflammation in COPD, smokers and nonsmokers","volume":"41","author":"Comer","year":"2013","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.bbadis.2018.06.021_bb0150","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.jhep.2010.01.003","article-title":"PalmitOleate attenuates palmitate-induced Bim and PUMA up-regulation and hepatocyte lipoapoptosis","volume":"52","author":"Akazawa","year":"2010","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bbadis.2018.06.021_bb0155","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1677\/JOE-08-0041","article-title":"Differential regulation of the endoplasmic reticulum stress response in pancreatic beta-cells exposed to long-chain saturated and monounsaturated fatty acids","volume":"197","author":"Diakogiannaki","year":"2008","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.bbadis.2018.06.021_bb0160","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.bbrc.2005.08.088","article-title":"Oleate prevents palmitate-induced cytotoxic stress in cardiac myocytes","volume":"336","author":"Miller","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbadis.2018.06.021_bb0165","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0092-8674(90)90148-8","article-title":"Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis","volume":"63","author":"Cheng","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2018.06.021_bb0170","doi-asserted-by":"crossref","first-page":"11709","DOI":"10.1074\/jbc.M111958200","article-title":"A principal role for the proteasome in endoplasmic reticulum-associated degradation of misfolded intracellular cystic fibrosis transmembrane conductance regulator","volume":"277","author":"Gelman","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2018.06.021_bb0175","first-page":"S138","article-title":"The unfolded protein response in chronic obstructive pulmonary disease","volume":"13","author":"Kelsen","year":"2016","journal-title":"Ann. Am. Thorac. Soc."},{"key":"10.1016\/j.bbadis.2018.06.021_bb0180","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1513\/pats.201001-017AW","article-title":"Role of endoplasmic reticulum stress in cystic fibrosis\u2013related airway inflammatory responses","volume":"7","author":"Ribeiro","year":"2010","journal-title":"Proc. Am. Thorac. Soc."},{"key":"10.1016\/j.bbadis.2018.06.021_bb0185","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1242\/jcs.026062","article-title":"Initiation and execution of lipotoxic ER stress in pancreatic {beta}-cells","volume":"121","author":"Cunha","year":"2008","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbadis.2018.06.021_bb0190","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1016\/j.rmed.2007.04.010","article-title":"Serum and bronchial lavage fluid concentrations of IL-8, SLPI, sCD14 and sICAM-1 in patients with COPD and asthma","volume":"101","author":"Hollander","year":"2007","journal-title":"Respir. Med."},{"key":"10.1016\/j.bbadis.2018.06.021_bb0195","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.cyto.2011.09.010","article-title":"Increased interleukin (IL)-8 and decreased IL-17 production in chronic obstructive pulmonary disease (COPD) provoked by cigarette smoke","volume":"56","author":"Zhang","year":"2011","journal-title":"Cytokine"},{"key":"10.1016\/j.bbadis.2018.06.021_bb0200","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1089\/jir.1998.18.851","article-title":"The bronchoalveolar lavage fluid of cystic fibrosis lung transplant recipients demonstrates increased interleukin-8 and elastase and decreased IL-10","volume":"18","author":"Dosanjh","year":"1998","journal-title":"J. Interf. Cytokine Res."},{"key":"10.1016\/j.bbadis.2018.06.021_bb0205","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1159\/000072006","article-title":"Expression and release of interleukin-8 by human bronchial epithelial cells from patients with chronic obstructive pulmonary disease, smokers, and never-smokers","volume":"70","author":"Schulz","year":"2003","journal-title":"Respiration"},{"key":"10.1016\/j.bbadis.2018.06.021_bb0210","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.atherosclerosis.2008.05.033","article-title":"Induction of proinflammatory cytokines by long-chain saturated fatty acids in human macrophages","volume":"202","author":"H\u00e5versen","year":"2009","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.bbadis.2018.06.021_bb0215","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1042\/BJ20050791","article-title":"Transcriptional regulation of lysophosphatidic acid-induced interleukin-8 expression and secretion by p38 MAPK and JNK in human bronchial epithelial cells","volume":"393","author":"Saatian","year":"2006","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbadis.2018.06.021_bb0220","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1378\/chest.10-1914","article-title":"p38 Mitogen-activated protein kinase pathways in asthma and COPD","volume":"139","author":"Chung","year":"2011","journal-title":"Chest"},{"key":"10.1016\/j.bbadis.2018.06.021_bb0225","doi-asserted-by":"crossref","first-page":"262","DOI":"10.4049\/jimmunol.175.1.262","article-title":"Dual effects of p38 MAPK on TNF-dependent bronchoconstriction and TNF-independent neutrophil recruitment in lipopolysaccharide-induced acute respiratory distress syndrome","volume":"175","author":"Schnyder-Candrian","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbadis.2018.06.021_bb0230","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1111\/j.1365-2958.2006.05484.x","article-title":"Control of fatty acid desaturation: a mechanism conserved from bacteria to humans","volume":"62","author":"Aguilar","year":"2006","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.bbadis.2018.06.021_bb0235","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1091\/mbc.e07-06-0600","article-title":"A lipid-mediated quality control process in the Golgi apparatus in yeast","volume":"19","author":"Pineau","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbadis.2018.06.021_bb0240","unstructured":"Romero, F., Hong, X., Shah, D., Kallen, C.B., Rosas, I., Guo, Z., Schriner, D., Barta, J., Shaghaghi, H., Hoek, J.B., et al. Lipid synthesis is required to resolve ER stress and limit fibrotic responses in the lung. Am. J. Respir. Cell Mol. Biol. (in press)."},{"key":"10.1016\/j.bbadis.2018.06.021_bb0245","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.jcf.2012.09.004","article-title":"Lung transplantation in cystic fibrosis normalizes essential fatty acid profiles","volume":"12","author":"Witters","year":"2013","journal-title":"J. Cyst. Fibros."},{"key":"10.1016\/j.bbadis.2018.06.021_bb0250","doi-asserted-by":"crossref","first-page":"E690","DOI":"10.1152\/ajpendo.90525.2008","article-title":"Effects of palmitate on ER and cytosolic Ca2+ homeostasis in {beta}-cells","volume":"296","author":"Gwiazda","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.bbadis.2018.06.021_bb0255","doi-asserted-by":"crossref","first-page":"37030","DOI":"10.1074\/jbc.M405195200","volume":"279","author":"Li","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2018.06.021_bb0260","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1126\/science.1128294","article-title":"Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes","volume":"313","author":"Ozcan","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2018.06.021_bb0265","doi-asserted-by":"crossref","first-page":"41748","DOI":"10.1074\/jbc.M105823200","article-title":"Inhibition of protein translocation across the endoplasmic reticulum membrane by sterols","volume":"276","author":"Nilsson","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2018.06.021_bb0270","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0005-2736(03)00056-7","article-title":"Lipid-protein interactions in biological membranes: a structural perspective","volume":"1612","author":"Lee","year":"2003","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.bbadis.2018.06.021_bb0275","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.bbamem.2004.05.012","article-title":"How lipids affect the activities of integral membrane proteins","volume":"1666","author":"Lee","year":"2004","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.bbadis.2018.06.021_bb0280","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0304-4157(98)00017-3","article-title":"Hydrophobic mismatch between proteins and lipids in membranes","volume":"1376","author":"Killian","year":"1998","journal-title":"Biochim. Biophys. Acta Rev. Biomembr."},{"key":"10.1016\/j.bbadis.2018.06.021_bb0285","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1016\/j.bbamcr.2014.01.009","article-title":"The role of MAPK signalling pathways in the response to endoplasmic reticulum stress","volume":"1843","author":"Darling","year":"2014","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Cell Res."},{"key":"10.1016\/j.bbadis.2018.06.021_bb0290","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0092586","article-title":"Endoplasmic reticulum stress-mediated activation of p38 MAPK, Caspase-2 and Caspase-8 leads to Abrin-induced apoptosis","volume":"9","author":"Mishra","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2018.06.021_bb0295","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1136\/thx.2004.030858","article-title":"Polyunsaturated fatty acids improve exercise capacity in chronic obstructive pulmonary disease","volume":"60","author":"Broekhuizen","year":"2005","journal-title":"Thorax"},{"key":"10.1016\/j.bbadis.2018.06.021_bb0300","first-page":"128","article-title":"Omega-3 polyunsaturated fatty acids and chronic obstructive pulmonary disease","volume":"18","author":"Wood","year":"2015","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"10.1016\/j.bbadis.2018.06.021_bb0305","first-page":"L597","article-title":"Linoleic acid supplement in cystic fibrosis: friend or foe?","volume":"299","author":"Vij","year":"2010","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"key":"10.1016\/j.bbadis.2018.06.021_bb0310","first-page":"334","article-title":"Chloride channel function is linked to epithelium-dependent airway relaxation","volume":"280","author":"Fortner","year":"2001","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"key":"10.1016\/j.bbadis.2018.06.021_bb0315","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/1465-9921-7-113","article-title":"Evidence that CFTR is expressed in rat tracheal smooth muscle cells and contributes to bronchodilation","volume":"7","author":"Vandebrouck","year":"2006","journal-title":"Respir. Res."},{"key":"10.1016\/j.bbadis.2018.06.021_bb0320","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/sj.bjp.0701637","article-title":"The relevance of resting tension to responsiveness and inherent tone of human bronchial smooth muscle","volume":"123","author":"Watson","year":"1998","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbadis.2018.06.021_bb0325","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1194\/jlr.M700388-JLR200","article-title":"Cell culture models demonstrate that CFTR dysfunction leads to defective fatty acid composition and metabolism","volume":"49","author":"Andersson","year":"2008","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbadis.2018.06.021_bb0330","series-title":"Biological Specimen Preparation for Transmission Electron Microscopy","author":"Glauert","year":"1998"},{"key":"10.1016\/j.bbadis.2018.06.021_bb0335","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1021\/jp036508g","article-title":"Coarse grained model for semiquantitative lipid simulations","volume":"108","author":"Marrink","year":"2004","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.bbadis.2018.06.021_bb0340","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1021\/acs.jctc.5b00209","article-title":"Computational lipidomics with insane: a versatile tool for generating custom membranes for molecular simulations","volume":"11","author":"Wassenaar","year":"2015","journal-title":"J. Chem. Theory Comput."},{"key":"10.1016\/j.bbadis.2018.06.021_bb0345","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1021\/ct700301q","article-title":"GROMACS 4: algorithms for highly efficient, load-balanced, and scalable molecular simulation","volume":"4","author":"Hess","year":"2008","journal-title":"J. Chem. Theory Comput."},{"key":"10.1016\/j.bbadis.2018.06.021_bb0350","doi-asserted-by":"crossref","DOI":"10.1063\/1.2408420","article-title":"Canonical sampling through velocity rescaling","volume":"126","author":"Bussi","year":"2007","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.bbadis.2018.06.021_bb0355","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1080\/00268978400101201","article-title":"A molecular dynamics method for simulations in the canonical ensemble","volume":"52","author":"Nos\u00e9","year":"1984","journal-title":"Mol. Phys."},{"key":"10.1016\/j.bbadis.2018.06.021_bb0360","doi-asserted-by":"crossref","first-page":"7182","DOI":"10.1063\/1.328693","article-title":"Polymorphic transitions in single crystals: a new molecular dynamics method","volume":"52","author":"Parrinello","year":"1981","journal-title":"J. Appl. Phys."},{"key":"10.1016\/j.bbadis.2018.06.021_bb0365","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1039\/B901487J","article-title":"Concerted diffusion of lipids in raft-like membranes","volume":"144","author":"Apajalahti","year":"2010","journal-title":"Faraday Discuss."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443918302254?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443918302254?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T04:46:40Z","timestamp":1760417200000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443918302254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":73,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["S0925443918302254"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2018.06.021","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modulation of cellular membrane properties as a potential therapeutic strategy to counter lipointoxication in obstructive pulmonary diseases","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2018.06.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V.","name":"copyright","label":"Copyright"}]}}